Coping With The Side Effects Of Metformin
Metformin is prescribed for some people with diabetes to help keep their blood sugar levels under control. Metformin works by encouraging the body to burn energy, leading to lower blood glucose levels. If you take metformin it is usually more effective at lowering blood glucose levels than if you are just careful about what you eat. Nausea Metformin has a number of side effects, the most common of which are gastrointestinal. More than one in 10 people who take metformin experience side effects including nausea, vomiting, diarrhoea, stomach pain, increased flatulence or loss of appetite. More than one in 100 patients who take the medication experience changes to their sense of taste - usually a metallic taste. A number of other very rare symptoms have also been reported. Fewer than one in 10,000 people who take metformin may experience: What to do about side effects All medications take some getting used to. The NHS advises that patients can avoid the more common gastrointestinal side effects by taking the medication during or after a meal. In order to guard against vitamin B12 deficiency - which in rare cases becomes apparent in patients who have taken the medication for a long time - the charity Diabetes UK recommends eating a healthy, balanced diet including foods rich in vitamin B12 such as meat, dairy products and eggs. However, it is not recommended for those prescribed metformin to also take vitamin B12 supplements unless advised to by their doctor. Patients who feel unwell or who are concerned about a side effect should talk to their GP, pharmacist or practice nurse. Immediate medical attention should be sought in cases of breathing difficulties, muscle cramps, stomach pain, weakness or hypothermia, which can be symptoms of lactic acidosis. Continue reading >>
Does Metformin/glucophage Make Your Hair Fall Out???!
(By the way, those 2 pills are the same). I'm taking 500 mg x 2 a day. In some diabetic forums I have read about this particular pill making your hair fall out. I am hysterical about my hair, and have been for 7 months!! I must have lost more than 1/3 of my hair!! I am now taking a (natural) pill which is costing me a fortune. It MIGHT have arrested, to a degree, the falling out, but I am SO unhappy about what happened to my hair. It's thin, fly-away, and more like duck down than my normal hair!! Has anyone had this experience, male or female?? I always had fine hair, but quite enough of it. Now it is so thin that I am embarrassed, and yet I cannot simply stop taking Glucophage. I have it coloured once a month (and no, it's not the salon products -- Redken -- which affects my hair!) I have always had my hair coloured, as early grey is in our family. I am over 60 now, but younger looking and not prepared to go bald !!!! Does anyone know about this problem?? And YES, I asked my doctor. His only "help" was that hair loss was not listed among the side effects!! Well, I'm SURE the pharmaceutical companies would NOT list that as a side-effect!!! Too much loss of money! The other problem is that all these medicines have side-effects, and Metformin/Glucophage is probably the lesser of the evils. Continue reading >>
Acupuncture For Pcos – Is It A Viable Alternative To Metformin?
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of childbearing age 1, 2. The signs and symptoms of PCOS are vast, but include disturbances in metabolic parameters (insulin resistance and increased risk for cardiovascular disease), sex hormone imbalances (elevated testosterone, estrogen and LH/FSH ratio), ultrasound diagnosis of cysts on the ovaries, acne, excess facial or body hair growth, irregular or absent menstrual cycles, anovulation and difficulty conceiving 2. In recent years, treatment approaches have evolved from a focus on targeting reproductive hormones to a shift towards healthy weight management and restoring insulin sensitivity as a first line treatment for PCOS. The mechanisms for restoring ovulation and improving hormone profiles in women with PCOS have been previously described in our previous blog on this topic. In this article, we will elaborate on the metabolic disturbances that characterize women with PCOS, as well as shed light on a novel approach for correcting these imbalances. Insulin resistance, a major causative factor in the pathophysiology of PCOS, is a condition where the cells and tissues of the body fail to respond normally to the presence of insulin. As a result, the pancreas will secrete additional insulin after a meal in order to take up glucose from the bloodstream. These ongoing heightened levels of insulin worsen the symptoms of PCOS, as they maintain imbalances in the sex hormones, which in turn lead to irregular menstruation, acne, facial hair growth, and difficulty getting pregnant. While even women of healthy BMI are frequently diagnosed with PCOS, up to 50% of women with PCOS are overweight, and commonly exhibit an accumulation of fat around the abdomen 3. This pattern of weight gain actually wo Continue reading >>
Side Effects Of Metformin
Metformin ("Glucophage") has a broad array of possible side effects and implications for your health. Has your doctor discussed with you all of the possible problems associated with metformin? Malaise Did you know that 10%- 25% of women who take Glucophage just don't feel well? They experience a general malaise, fatigue and occasional achiness that lasts for varying lengths of time. Malaise a warning signal for your doctor to closely monitor your body systems, including liver, kidneys, and GI tract. GI Disturbance About one third of women on metformin experience gastrointestinal disturbances, including nausea, occasional vomiting and loose, more frequent bowel movements, or diarrhea. This problem occurs more often after meals rich in fats or sugars, so eating a healthier diet will help. The symptoms lessen over time, so if you can tolerate the GI upset for a few weeks, it may go away. Some women have found it helps to start with a very low dose and gradually increase it. Vitamin B12 Malabsorption Most people think that aside from possible gastrointestinal upset, there are no side effects from taking metformin, and thus you can take it for a very long time. This is not true! The sneakiest side effect of all is a vitamin B12 insufficiency. A substance formed in the stomach called "intrinsic factor" combines with B12 so that it can be transferred into the blood. Metformin interferes with the ability of your cells to absorb this intrinsic factor-vitamin B12 complex.(12) Over the long term, vitamin B12 insufficiency is a significant health risk. B12 is essential to the proper growth and function of every cell in your body. It's required for synthesis of DNA and for many crucial biochemical functions. There is also a link between B12 insufficiency and cardiovascular disease. Continue reading >>
Metformin And Hair Loss
One of the most frustrating problems experienced by women with PCOS (Polycystic Ovarian Syndrome) is the loss of hair, as well as the growth of hair in unwanted places. Metformin is a medication often used by women with PCOS to help regulate the symptoms of PCOS. Specifically, metformin helps a woman’s body to regulate her blood sugar levels. However, some women with PCOS who take metformin may be concerned that metformin can lead to hair loss. There is no research data that indicates that metformin is responsible for any hair loss. It is much more likely that women with PCOS who take Metformin experience hair loss as a result of their PCOS, rather than as a result of taking metformin. It is important to understand exactly how PCOS causes hair loss. When a woman has PCOS, her body tends to produce androgens. Androgens are a type of hormone that can cause a variety of problems, such as acne. Androgens can also interfere with ovulation, causing fertility problems. One of the androgens, testosterone, can cause unwanted hair growth when there is too much of it in the blood. Testosterone coverts into dihydrotestosterone, sometimes known as DHT. Body hair is affected by dihydrotestosterone more than the hair of the head. If a woman has a large amount of dihydrotestosterone in her system, the body hairs that are normally very fine will become coarse, and tend to grow toward the navel and on the face. If dihydrotestosterone and other androgens are at very high levels, the head on the hair can actually react differently than body hair. It is much more sensitive to these hormones, and will fall out rather than growing. This can lead to male-pattern balding in women. Metformin does not directly affect the levels of androgens in a woman’s body. Hair loss and unwanted hair growt Continue reading >>
Pcos & Metformin - Bcrm
Metformin may be used for treatment of symptoms associated with Polycystic ovarian syndrome (PCOS). Metformin may help correct your hormone imbalance and lead to regular periods and improved fertility. It may also help women with increased facial hair, acne and scalp hair thining/loss. Metformin is used widely for the treatment of PCOS, however, it is currently only licensed for the treatment of diabetes mellitus. Metformin can help women with PCOS who have problems with ovulation, ovulate regularly. It can also help women with PCOS increase the chances of getting pregnant with IVF or ICSI treatment as well as reduce the risk on ovarian hyperstimulation syndrome (OHSS). Metformin works by by helping your body respond better to its own insulin, a hormone which regulates sugar levels. Women with PCOS often have high levels of insulin, therefore treatment with Metformin may help improve the symptoms of the syndrome. It is also used in the treatment of diabetes. However, Metformin will not make you low in blood sugar if you are not diabetic. What kind of side effects can Metformin cause? One in six women will experience side effects, nausea (feeling sick) and diarrhoea are commonest. These usually settle with 3-4 weeks. Women may also experience a metallic taste in their mouth. Taking your Metformin with meals can help reduce these side effects. Your doctor will tell you how many tablets to take and how often. Treatment is usually started at a low dose and increased slowly. In the first week of treatment start with 500mg Metformin after the main meal. If you are not having side effects, increase to 500mg twice a day. In the third week increased to 500mg three times a day or 850mg twice daily. If you have side effects, continue on the dose you can tolerate until they settle Continue reading >>
Savings On Drugs : Pcos Hair Loss Metformin
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Patient Assistance Program - Pcos Hair Loss Metformin
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Metformin Acne Treatment
Metformin is an anti-hyperglycemic drug used to treat patients with type 2 diabetes and to treat women with polycystic ovary syndrome (POCS) and hirsutism, excessive or unwanted facial or body hair. Metformin also has benefits in treating acne in patients with hyperandrogenism or excessive production of androgen. Hyperandrogenenism causes acne vulgaris, which is the increased accumulation of oil and bacteria in the skin pores and the formation of papules, pustules or nodules. Video of the Day Metformin was approved by the Food and Drug Administration (FDA) in 1995 only for the treatment of type 2 diabetes. According to the Northwestern University website, metformin is not FDA approved to treat POCS symptoms. However, treatment with metformin benefits women suffering with POCS because of its effect in reducing insulin, testosterone and glucose levels. These effects help to reduce the symptoms of acne, hirsutism, abdominal obesity and amenorrhea that are all symptoms of POCS. Metformin Effects on Acne Metformin is used to treat acne in specific conditions such as PCOS, which causes serious hormonal imbalances that cause acne outbreaks. Metformin works to balance the hormones and control the acne outbreaks. The side effects of metformin include gastrointestinal symptoms of nausea and vomiting, abdominal bloating and diarrhea. These symptoms may be minimized by starting with a low dosage that is gradually increased over a few weeks. Metformin will also affect the absorption of vitamin B12; long-term treatment with metformin may lead to anemia. A rare and serious side effect of metformin is lactic acidosis, too much acid in the body. Therefore, it’s important to have a serum creatinine test prior to starting metformin therapy and to have liver enzymes levels monitored ever Continue reading >>
- Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE)
- Is Metformin an Effective Treatment for Type 2 Diabetes?
- Is It Time to Change the Type 2 Diabetes Treatment Paradigm? No! Metformin Should Remain the Foundation Therapy for Type 2 Diabetes
Metformin - Oral, Glucophage
are allergic to dapagliflozin or any of the ingredients in FARXIGA. Symptoms of a serious allergic reaction may include skin rash, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. If you have any of these symptoms, stop taking FARXIGA and contact your healthcare provider or go to the nearest hospital emergency room right away have severe kidney problems or are on dialysis. Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with FARXIGA Dehydration (the loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at a higher risk of dehydration if you have low blood pressure; take medicines to lower your blood pressure, including water pills (diuretics); are 65 years of age or older; are on a low salt diet, or have kidney problems Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with FARXIGA. Ketoacidosis is a serious condition which may require hospitalization and may lead to death. Symptoms may include nausea, tiredness, vomiting, trouble breathing, and abdominal pain. If you get any of these symptoms, stop taking FARXIGA and call your healthcare provider right away. If possible, check for ketones in your urine or blood, even if your blood sugar is less than 250 mg/dL Kidney problems. Sudden kidney injury occurred in people taking FARXIGA. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or excessive heat exposure Serious urinary tract infections (UTI), some that lead to hospitalization, occu Continue reading >>
Pcos Treatments
If a woman is not seeking to become pregnant, hormonal birth control (most often birth control pills) is a standard treatment. Birth control pills regulate periods and improve excess hair growth and acne by lowering androgen levels and protect the endometrium (inner lining of the uterus) against abnormal cell growth. Older types of birth control pills have lower risk for dangerous blood clots and are preferable over new types of birth control pills. Although metformin is not approved by the FDA for treatment of PCOS, many doctors prescribe it for PCOS patients. Metformin is a medicine that makes the body more sensitive to insulin. This can help lower elevated blood glucose levels, insulin levels, and androgen levels. People who use metformin may lose some weight as well. Metformin can improve menstrual patterns, but metformin doesn’t help as much for unwanted excess hair. Many women who are diagnosed with PCOS are often automatically prescribed metformin. However, it's important to have a reason for taking metformin and not be on it just because of a diagnosis of PCOS. Discuss with your doctor the reason why you are taking metformin and whether it is providing a benefit to you. Clomiphene (Clomid) is an oral medication that is the most common treatment used to induce ovulation. The use of both metformin and clomiphene has about the same fertility results as clomiphene use alone. A benefit is that metformin may help reduce the risk for ovarian hyperstimulation syndrome (see also "What is ovarian hyperstimulation syndrome (OHSS) during assisted reproductive technology (ART) fertility treatments. Other treatments to stimulate ovulation include another oral medication called letrozole (Femara) and gonadotropins which are hormones that are given by injection. In vitro fert Continue reading >>
Metformin For The Treatment Of Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a disorder of body metabolism that affects 5-10% of women and can cause infrequent periods, weight gain, acne, unwanted hair growth and infertility. PCOS should not be confused with the incidental finding of polycystic ovaries on an ultrasound scan which occur in about 20% of the female population and usually do not cause any symptoms. The cause of PCOS is not fully understood but is thought to have a genetic component. The small cysts seen in the ovaries do not cause PCOS but are the result of the underlying disturbance of metabolism. Most women with PCOS do not have every symptom and the treatment that a doctor recommends is usually chosen to treat the symptoms that bother the woman. In recent years there has been a lot of interest in the use of Metformin to treat the symptoms of PCOS. This information sheet aims to answer many of the questions that women have about this treatment. What is Metformin? Metformin is a medicine that is taken by mouth. It is from a family of drugs known as biguanides and was developed to treat type 2 (late onset) diabetes. Why is it used to treat PCOS? There are a number of similarities between PCOS and adult-onset diabetes. In both conditions, people have a resistance to the effects of insulin with resulting high levels of insulin in their blood stream. These high insulin levels cause an increased production of androgens (male-type hormones that can cause acne and unwanted hair growth) in the ovaries and adrenal glands. This in turn affects the pituitary hormones (LH and FSH) that normally stimulate the ovaries to produce eggs. The result is often irregular infertile periods. Metformin increases the effectiveness of insulin, resulting in a lowering of blood insulin levels which in turn lowers the androg Continue reading >>
- Type 1 Diabetes and Polycystic Ovary Syndrome: Systematic Review and Meta-analysis
- Polycystic Ovary Syndrome and Diabetes
- Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE)
The Low Down On Metformin And Vitamin B12 Deficiency
So many women with PCOS are prescribed Metformin (an insulin-sensitizing drug) to manage their Polycystic Ovarian Syndrome. And for good reason too. Metformin has been shown to improve many aspects of PCOS, including weight loss, fertility and improved testosterone levels (1). But, it also leads to Vitamin B12 deficiency if used at high doses or for long periods of time. So, here’s what you need to know about Metformin and Vitamin B12 deficiency with PCOS. What is Metformin? As I have already mentioned, Metformin is an insulin sensitizing drug that is often prescribed for women withPCOS. It works by decreasing absorption of glucose through the intestines, lowering the amount of glucose produced by the liver and making the body more sensitive to the insulin that is being produced. The overall effect of Metformin use for PCOS is lowered testosterone levels, improved ovulation and fertility as well as a more regular menstrual cycle. This is all sounding good, right? Well, it is good although there are some nasty side effects. A full discussion on Metformin is not going to be dealt with now, though. I really want to hone in on Metformin’s effect of Vitamin B12 levels as this could be affecting you right now. A free 6 lesson course that has helped women with PCOS around the world learn how to see lasting changes in their PCOS symptoms. Ready to join? Vitamin B12 Vitamin B12 is a vitamin that is vital for the body’s functioning. It is important for red blood cell formation, neurological function and DNA formation. If you are deficient in this important vitamin, it could lead to anaemia and neurological problems. (including memory loss – something that I have seen cropping up more often in PCOS communities). (2) Metformin and Vitamin B12 Right, so this is where it gets Continue reading >>
Is Your Medication Causing Hair Loss? These 11 Drugs Are Common Culprits
Medications certainly aren’t the only thing that will cause hair loss, but they are often overlooked. If you feel like you are losing your hair, one of your first steps is to look at your medication list. You will also pay attention to other well known causes including poor diet (caloric or protein restriction), major illness or surgeries, major psychological stress, significant weight loss, chronic iron deficiency, thyroid disorders, and childbirth. Don’t have any of those? Well then lets look at which medications are common culprits of hair loss caused by drugs: The cholesterol lowering drugs, aka “the Statins”. Only atorvastatin (Lipitor) and simvastatin (Zocor) have reported hair loss as an adverse effect, not the newer statin Crestor (rosuvastatin). The anticoagulants (warfarin or Coumadin) are commonly used blood thinners and have been reported to cause hair loss. The ACE Inhibitor blood pressure medications captopril and lisinopril are the two in this category that have reported hair loss in > 1% of folks taking them. Soriatane (acitretin) is a pill used for the treatment of psoriasis that has a well known adverse effect of hair loss. Amiodarone (Cordarone or Pacerone) is used in patients with arrhythmias like atrial fibrillation and has a rare but reported side effect of hair loss. The anticonvulsant valproate (Depakote). Depakote is used for seizure disorders, controlling mania in bipolar disorder and for migraine prevention. Valproate does carry reports of hair loss. Cimetidine (Tagamet) is an over the counter acid reducer used for ulcers and reflux disease and hair loss has been reported, though infrequently, in people taking it. Colchicine is a medication used for the treatment of acute Gout attacks. It does carry a very small risk of hair loss. Horm Continue reading >>
