Efficacy, Dose-response Relationship And Safety Of Once-daily Extended-releasemetformin (glucophage Xr) In Type 2 Diabetic Patients With Inadequate Glycaemiccontrol Despite Prior Treatment With Diet And Exercise: Results From Twodouble-blind, Placebo-controlled Studies.
1. Diabetes Obes Metab. 2005 Jan;7(1):28-39. Efficacy, dose-response relationship and safety of once-daily extended-releasemetformin (Glucophage XR) in type 2 diabetic patients with inadequate glycaemiccontrol despite prior treatment with diet and exercise: results from twodouble-blind, placebo-controlled studies. Fujioka K(1), Brazg RL, Raz I, Bruce S, Joyal S, Swanink R, Pans M. (1)Department of Endocrinology, Scripps Clinic, La Jolla, San Diego, CA 92130, USA. [email protected] AIM: The efficacy, dose-response relationships and safety of an extended-release formulation of metformin (Glucophage) XR) were evaluated in two double-blind,randomized, placebo-controlled studies of 24 and 16 weeks' duration, in patients with inadequate glycaemic control despite diet and exercise. Protocol 1 provided an evaluation of metformin XR at a commonly used dosage. Protocol 2 evaluateddifferent dosages of metformin XR.METHODS: In Protocol 1, 240 patients were randomized to receive metformin XR 1000mg once daily. or placebo in a 2:1 ratio for 12 weeks (patients could receivemetformin XR 1500 mg during weeks 12-24 if required). In Protocol 2, 742 patientswere randomized to receive metformin XR 500 mg once daily, 1000 mg once daily,1500 mg once daily, 2000 mg once daily, 1000 mg twice daily or placebo for 16weeks. The primary endpoint in each study was the change from baseline in HbA(1C)at 12 weeks (Protocol 1) or 16 weeks (Protocol 2).RESULTS: Metformin XR reduced HbA(1C) in Protocol 1, with mean treatmentdifferences for 1000 mg once daily vs. placebo of -0.7% at 12 weeks and -0.8% at 24 weeks (p < 0.001 for each). In Protocol 2, a clear dose-response relationship was evident at doses up to 1500 mg, with treatment differences vs. placebo of-0.6% (500 mg once daily), -0.7% (100 Continue reading >>
Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. Limited evidence suggests metformin may prevent the cardiovascular disease and cancer complications of diabetes. It is not associated with weight gain. It is taken by mouth. Metformin is generally well tolerated. Common side effects include diarrhea, nausea and abdominal pain. It has a low risk of causing low blood sugar. High blood lactic acid level is a concern if the medication is prescribed inappropriately and in overly large doses. It should not be used in those with significant liver disease or kidney problems. While no clear harm comes from use during pregnancy, insulin is generally preferred for gestational diabetes. Metformin is in the biguanide class. It works by decreasing glucose production by the liver and increasing the insulin sensitivity of body tissues. Metformin was discovered in 1922. French physician Jean Sterne began study in humans in the 1950s. It was introduced as a medication in France in 1957 and the United States in 1995. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. Metformin is believed to be the most widely used medication for diabetes which is taken by mouth. It is available as a generic medication. The wholesale price in the developed world is between 0.21 and 5.55 USD per month as of 2014. In the United States, it costs 5 to 25 USD per month. Medical uses Metformin is primarily used for type 2 diabetes, but is increasingly be Continue reading >>
GLUCOPHAGE® (metformin hydrochloride) Tablets GLUCOPHAGE® XR (metformin hydrochloride) Extended-Release Tablets DESCRIPTION GLUCOPHAGE® (metformin hydrochloride) Tablets and GLUCOPHAGE® XR (metformin hydrochloride) Extended-Release Tablets are oral antihyperglycemic drugs used in the management of type 2 diabetes. Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride) is not chemically or pharmacologically related to any other classes of oral antihyperglycemic agents. The structural formula is as shown: Metformin hydrochloride is a white to off-white crystalline compound with a molecular formula of C4H11N5 HCl and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pK of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68. GLUCOPHAGE tablets contain 500 mg, 850 mg, or 1000 mg of metformin hydrochloride. Each tablet contains the inactive ingredients povidone and magnesium stearate. In addition, the coating for the 500 mg and 850 mg tablets contains hypromellose and the coating for the 1000 mg tablet contains hypromellose and polyethylene glycol. GLUCOPHAGE XR contains 500 mg or 750 mg of metformin hydrochloride as the active ingredient. GLUCOPHAGE XR 500 mg tablets contain the inactive ingredients sodium carboxymethyl cellulose, hypromellose, microcrystalline cellulose, and magnesium stearate. GLUCOPHAGE XR 750 mg tablets contain the inactive ingredients sodium carboxymethyl cellulose, hypromellose, and magnesium stearate. System Components And Performance GLUCOPHAGE XR comprises a dual hydrophilic polymer matrix system. Metformin hydrochloride is combined with a drug release controlling polymer to form an “inne Continue reading >>
Multiple Benefits Of Metformin | Life Extension Magazine
As the type II diabetic condition progresses, many people gain weight and develop more fat cells.2 Treating type II diabetes with insulin-enhancing therapy increases the risk of cardiovascular complications, induces weight gain, and fails to correct the underlying cause of the disease. Many type II diabetics produce too much insulin in a futile attempt to drive glucose into insulin-resistant cells. When doctors prescribe insulin-enhancing drugs to these type II diabetics, a temporarily reduction of serum glucose may occur, but the long-term effects of this excess insulin can be devastating. An ideal anti-diabetic drug would enhance cellular insulin sensitivity, inhibit excess intestinal absorption of sugar, reduce excess liver production of glucose, promote weight loss and reduce cardiovascular risk factors. Metformin (Glucophage) is the one drug that does all of this and more. Metformin works by increasing the number of muscle and adipocyte (fat cell) insulin receptors and the attraction for the receptor. It does not increase insulin secretion, it only increases insulin sensitivity. Therefore, metformin is not associated with causing hypoglycemia. This activity reduces insulin levels by increasing the sensitivity of peripheral tissues to the effects of insulin by rejuvenating the response, and restoring glucose and insulin to younger physiological levels that may cause weight loss and most certainly a decrease in the body's total fat content.3-7 In an study published by the American Diabetes Association, metformin was found to decrease the fasting plasma glucose concentration by -60 to -70mg/dl in patients with non-insulin dependent type II diabetes.1 Metformin also reduced hemoglobin A1C levels, a blood measurement of glycosylation. One of the most devastating conseq Continue reading >>
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Information about this medication and how to buy online can be Metformin Glucophage Buy found at HealthExpress Metformin (Glucophage) is an oral medicine recommended to control blood sugar level degrees in individuals with type 2 diabetes. Metformin (Glucophage, Glucophage XR, Glumetza, Fortamet, Riomet) is a prescription drug used for treating type 2 diabetes in adults and children. Includes Glucophage side effects, interactions and indications Metformin (Glucophage) is an oral medicine recommended to control blood sugar level degrees in individuals with type 2 diabetes. Prices start at $4. This drug can Robaxin Buy Canada be combined with insulin Save money when safely buying Glucophage XR online. This drug can be combined with insulin.. Com is offering quality Glucophage (Metformin) drugs at lower prices and same great service. PlanetDrugsDirect is a safe and secure Canadian international prescription referral service canadianpharmacyking. Metformin is a medical product for the treatment of the pancreatic diabetes type 2 and the obesity therapy. Buy Glucophage Xr online (Metformin) 500 mg discount for sale order price get purchase cheap order. Glucophage SR has been proven to effectively control blood sugar levels. Buy Naltrexone Hydrochloride You have to be especially cautious if you Buy Metformin Metformin 500mg available at canadian pharmacy at the best price. Buy Metformin quickly and safely online at euroClinix. Glucophage (metformin) is used in patients with type 2 (non-insulin-dependent) diabetes. Call us free at: 1-877-745-9217. Buy Metformin quickly and safely online at euroClinix. Metformin (Glucophage) can be recommended by your medical company to help you Levitra Pill Price keep your diabetes controlled. Glucophage XR is used alone or with other medicati Continue reading >>
Description And Brand Names
Drug information provided by: Micromedex US Brand Name Fortamet Glucophage Glucophage XR Glumetza Riomet Descriptions Metformin is used to treat high blood sugar levels that are caused by a type of diabetes mellitus or sugar diabetes called type 2 diabetes. With this type of diabetes, insulin produced by the pancreas is not able to get sugar into the cells of the body where it can work properly. Using metformin alone, with a type of oral antidiabetic medicine called a sulfonylurea, or with insulin, will help to lower blood sugar when it is too high and help restore the way you use food to make energy. Many people can control type 2 diabetes with diet and exercise. Following a specially planned diet and exercise will always be important when you have diabetes, even when you are taking medicines. To work properly, the amount of metformin you take must be balanced against the amount and type of food you eat and the amount of exercise you do. If you change your diet or exercise, you will want to test your blood sugar to find out if it is too low. Your doctor will teach you what to do if this happens. Metformin does not help patients does not help patients who have insulin-dependent or type 1 diabetes because they cannot produce insulin from their pancreas gland. Their blood glucose is best controlled by insulin injections. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Tablet Tablet, Extended Release Solution Copyright © 2017 Truven Health Analytics Inc. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Continue reading >>
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Glucophage (metformin) Is The First Choice Medicine To Control Your Blood Sugar And Lower The Risk Of Death From Diabetes, Although A Few People May Not Tolerate The Stomach Side Effects.
Our bottom line Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects. Improves sugar control and lowers A1c levels as much as 2%. One of the few diabetes medicines that lowers the risk of death from diabetes-related complications. Rarely causes low blood sugar. Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping. Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take. Excessive or chronic alcohol use can increase the risk of a dangerous side effect. Glucophage (metformin) is an anti-diabetic drug. It lowers the amount of sugar your body makes or absorbs, and allows your body use the existing insulin better. Sign up and get Pill Talk, the latest in health & medicine news from Iodine What to expect when you take Glucophage (metformin) for Type 2 diabetes Effectiveness Source: FDA product label and Iodine pharmacists Where we got our data » Higher risk if: › Kidney problems › Liver problems › Congestive heart failure › Using contrast dye for procedures › Surgery › Alcohol use Glucophage (metformin) can cause this rare life-threatening condition. Your doctor will check your kidneys and liver before you start. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. You're more likely to get this if you already have kidney problems. Glucophage (metformin) should be stopped 48 hours before and after surgery or any imaging procedure needing contrast dye. This is a black box warning. The FDA requires this warning when there is a significant risk Continue reading >>
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Metformin is used to control blood sugar levels for those with type 2 diabetes. It can sometimes be used in combination with insulin or other medications, but is not used to treat type 1 diabetes. Before using Metformin, be sure to consult your doctor and consider the risks of taking the medicine. This is a decision you and your doctor will make. Consider the following before using Metformin: Tell your doctor if you have ever had any unusual or allergic reaction to Metformin or any other medications. You should make your physician aware of any other allergies, such as foods, allergies to dyes, preservatives, or animals. There is no evidence that suggests there are pediatric-specific problems that would limit the usefulness of metformin oral solution and tablets in children ages 10 to 16. However, safety and efficacy of Metformin extended-release tablets in children have not been established. Appropriate studies to correlate the relationship of age to the effects of Metformin haven’t been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of Metformin in the elderly. However, older patients are more likely to have age-related kidney problems. Adequate studies show no evidence of risk to the fetus during pregnancy. Studies show that Metformin poses minimal risk to the infant when used during breastfeeding. Consult your doctor before using Metformin while pregnant or breast-feeding. Other Medical Issues The presence of certain medical problems may affect the use of Metformin. Consult with your doctor before taking Metformin if you have any of the following conditions: Severe breathing problems (severe asthma, obstructive lung disease) Blood problems (anemia, vitamin B12 deficiency) Kidney Disease Liver Disease Inst Continue reading >>
Metformin, Oral Tablet
Metformin oral tablet is available as both a generic and brand-name drug. Brand names: Glucophage, Glucophage XR, Fortamet, and Glumetza. Metformin is also available as an oral solution but only in the brand-name drug Riomet. Metformin is used to treat high blood sugar levels caused by type 2 diabetes. FDA warning: Lactic acidosis warning This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects. Lactic acidosis is a rare but serious side effect of this drug. In this condition, lactic acid builds up in your blood. This is a medical emergency that requires treatment in the hospital. Lactic acidosis is fatal in about half of people who develop it. You should stop taking this drug and call your doctor right away or go to the emergency room if you have signs of lactic acidosis. Symptoms include tiredness, weakness, unusual muscle pain, trouble breathing, unusual sleepiness, stomach pains, nausea (or vomiting), dizziness (or lightheadedness), and slow or irregular heart rate. Alcohol use warning: You shouldn’t drink alcohol while taking this drug. Alcohol can affect your blood sugar levels unpredictably and increase your risk of lactic acidosis. Kidney problems warning: If you have moderate to severe kidney problems, you have a higher risk of lactic acidosis. You shouldn’t take this drug. Liver problems warning: Liver disease is a risk factor for lactic acidosis. You shouldn’t take this drug if you have liver problems. Metformin oral tablet is a prescription drug that’s available as the brand name drugs Glucophage, Glucophage XR, Fortamet, and Glumetza. Glucophage is an immediate-release tablet. All of the other brands are extended-r Continue reading >>
Glucophage Side Effects
Generic Name: metformin (met FOR min) Brand Names: Fortamet, Glucophage, Glucophage XR, Glumetza, Riomet What is Glucophage? Glucophage (metformin) is an oral diabetes medicine that helps control blood sugar levels. Glucophage is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Glucophage is sometimes used together with insulin or other medications, but it is not for treating type 1 diabetes. Important information You should not use Glucophage if you have severe kidney disease or diabetic ketoacidosis (call your doctor for treatment). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking Glucophage. Metformin may cause a serious condition called lactic acidosis. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired. Get emergency medical help if you have signs of an allergic reaction to Glucophage: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Some people develop lactic acidosis while taking Glucophage. Early symptoms may get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness; numb or cold feeling in your arms and legs; trouble breathing; feeling dizzy, light-headed, tired, or very weak; stomach pain, nausea with vomiting; or slow or uneven heart rate. Common Glucophage side effects may include: low blood sugar; nausea, upset stomach; or diarrhea. This is not a complete list of side effects and others may occur. Continue reading >>
Glucophage (metformin) And Diabetes
Tweet Glucophage and Metformin are often mentioned in relation to diabetes treatment. But what exactly is Glucophage and how does Glucophage help control type 2 diabetes? The following guide to Glucophage should help you to understand more about this medication, its side effects and its value. What is Glucophage? Glucophage tablets (and Glucophage SR tablets) each have an active ingredient called Metformin hydrochloride. Metformin is widely used to aid in the control of blood glucose levels amongst people with type 2 diabetes. How does Glucophage help people with type 2 diabetes? Amongst people with type 2 diabetes, the pancreas fails to produce sufficient levels of insulin. Furthermore, the cells in the body may be resistant to any insulin that is present. Normally, insulin would instruct cells to remove sugar from the blood, but in people with diabetes blood sugar levels can climb too high. As we said before, Glucophage contains the ingredient Metformin. Metformin (Metformin hydrochloride) is a type of medicine known as a biguanide. This works to lower the amount of sugar in the blood of people with diabetes. It does this by lowering the amount of sugar produced in the liver, and also increasing the sensitivity of muscle cells to insulin. The cells are therefore more able to remove sugar from the blood. Metformin also slows the absorption of sugars from the intestines. Metformin lowers blood sugar levels between and after meals. Who is Glucophage prescribed to? Glucophage is usually prescribed as a treatment for people with type 2 diabetes who are overweight or obese. When diet and exercise fail to adequately control blood glucose levels, Glucophage is prescribed. Sometimes, this medicine is used in conjunction with other anti-diabetic medication. How often do people Continue reading >>
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Glucophage Oral : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - Webmd
Nausea , vomiting , stomach upset, diarrhea , weakness , or a metallic taste in the mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. If stomach symptoms return later (after taking the same dose for several days or weeks), tell your doctor right away. Stomach symptoms that occur after the first days of your treatment may be signs of lactic acidosis . Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Metformin does not usually cause low blood sugar ( hypoglycemia ). Low blood sugar may occur if this drug is prescribed with other diabetes medications . Talk with your doctor or pharmacist about whether the dose of your other diabetes medication(s) needs to be lowered. Symptoms of low blood sugar include sudden sweating , shaking, fast heartbeat, hunger , blurred vision , dizziness , or tingling hands/feet. It is a good habit to carry glucose tablets or gel to treat low blood sugar . If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor about the reaction right away. Low blood sugar is more likely if you drink large amounts of alcohol, do unusually heavy exercise , or do not consume enough calories from food. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal. Symptoms of high blood sugar ( hyperglycemia ) include thirst, increased urination, confusion, drowsiness, flushing, rapid Continue reading >>
Hiv & Aids Information :: A To Z Of Other Drugs - Metformin Hydrochoride (glucophage / Glucophage Sr)
Metformin hydrochoride (Glucophage / Glucophage SR) Metformin hydrochoride (Glucophage / Glucophage SR) Metformin hydrochoride (Glucophage / Glucophage SR) is an anti-diabetes drug. It is particularly useful in treating diabetes in patients with insulin resistance and obesity. Metformin can be taken alone, or if this is not effective, in combination with other drugs such as rosiglitazone (Avandia). Metformin and rosiglitazone are available in a combination tablet called Avandamet, manufactured by GlaxoSmithKline. The way in which metformin works is uncertain, although it is thought to reduce the bodys rate of glucose production in the liver. It also reduces the rate of glucose absorption from the gut. Metformin can reduce the insulin resistance that can occur as a side-effect of HIV treatment, notably with protease inhibitors. The drug can also improve perturbations of blood fat and sugar levels that can occur with HIV treatment, particularly by reducing triglyceride levels. These improvements can reduce the chance that a patient will suffer a stroke or heart attack. Metformin also reduces fat accumulation around the internal organs. However, it can worsen fat loss from under the skin, a more worrying aspect of fat redistribution for most HIV-positive patients. 1 2 3 4 5 Side-effects of metformin include diarrhoea, stomach pain, nausea and vomiting. These can be reduced by taking the drug with or after food. Metformin can also cause elevated levels of lactic acid in the blood, although this is usually only seen in patients with liver, heart or kidney problems. However, lactic acidosis is also a side-effect of some nucleoside reverse transcriptase inhibitors (NRTIs), notably ddI (didanosine, Videx / VidexEC) and d4T (stavudine, Zerit). Patients taking these drugs with m Continue reading >>
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Glucophage, Glucophage Xr (metformin) Dosing, Indications, Interactions, Adverse Effects, And More
Initial: 500 mg PO q12hr or 850 mg PO qDay with meals; increase q2Weeks Maintenance: 1500-2550 mg/day PO divided q8-12hr with meal Glucophage XR: 500 mg PO qDay with dinner; titrate by 500 mg/day qWeek; not to exceed 2000 mg/day Fortamet: 500-1000 mg PO qDay; titrate by 500 mg/day qWeek; not to exceed 2500 mg/day Glumetza: 1000 mg PO qDay; titrate by 500 mg/day qWeek; not to exceed 2000 mg/day Hepatic impairment: Avoid use; risk of lactic acidosis eGFR 30-45 mL/min/1.73 m: Not recommended to initiate treatment Monitor eGFR at least annually or more often for those at risk for renal impairment (eg, elderly) If eGFR falls below 45mL/min/1.73 m while taking metformin, risks and benefits of continuing therapy should be evaluated If eGFR falls below 30 mL/min/1.73 m: while taking metformin, discontinue the drug Orphan designation for treatment of pediatric polycystic ovary syndrome EffRx Pharmaceuticals SA; Wolleraustrass 41 B; 8807 Freienbach (SZ); SWITZERLAND Orphan designation for treatment of progressive myoclonus epilepsy type 2 (Lafora disease) Consorcio Centro de Investigacin Biomdica en Red, M.P. (CIBER); Monforte de Lemos, 3-5 Pabellon 11; Madrid, Spain Maintenance: Titrate qWeek by 500 mg; no more than 2000 mg/day in divided doses Initial: 500 mg PO q12hr or 850 mg PO qDay with meals; increase q2Weeks Maintenance: 1500-2550 mg/day PO divided q8-12hr with meal Glucophage XR: 500 mg PO qDay with dinner; titrate by 500 mg/day qWeek; not to exceed 2000 mg/day Fortamet: 500-1000 mg PO qDay; titrate by 500 mg/day qWeek; not to exceed 2500 mg/day eGFR 30-45 mL/min/1.73 m: Initiating not recommended Obtain GFR at least annually in all patients taking metformin; assess eGFR more frequently in patients at increased risk for renal impairment (eg, elderly) If eGFR falls to <4 Continue reading >>
NOTICE: This Consumer Medicine Information (CMI) is intended for persons living in Australia. What is in this leaflet This leaflet answers some common questions about Glucophage. It does not contain all the available information. It does not take the place of talking to your doctor, diabetes educator or pharmacist. All medicines have benefits and risks. Your doctor has weighed the risks of you taking Glucophage against the benefits expected for you. If you have any concerns about taking this medicine, talk to your doctor, pharmacist or diabetes educator. What Glucophage is used for Glucophage is used to control blood glucose (the amount of sugar in the blood) in people with diabetes mellitus. type 1 diabetes, also called insulin dependent diabetes or juvenile onset diabetes, when insulin alone is not enough to control blood glucose levels type 2 diabetes, also called non-insulin dependent diabetes mellitus (NIDDM) or maturity onset diabetes. It is especially useful in those who are overweight, when diet and exercise are not enough to lower high blood glucose levels (hyperglycaemia) Glucophage can be used alone, or in combination with other medicines for treating diabetes. Ask your doctor if you have any questions about why Glucophage has been prescribed for you. Glucophage is not recommended for use in children, except for those with insulin-resistant diabetes who are being treated in hospital. Glucophage is available only with a doctor's prescription. How Glucophage works Glucophage belongs to a group of medicines called biguanides. Glucophage lowers high blood glucose (hyperglycaemia) by helping your body make better use of the insulin produced by your pancreas. People with type 2 diabetes are unable to make enough insulin or their body does not respond properly to th Continue reading >>