Glipizide/metformin Hcl Tablets Rx
Select the drug indication to add to your list Glipizide/metformin HCl; 2.5mg/250mg, 2.5mg/500mg, 5mg/500mg. Indications for Glipizide/Metformin HCl Tablets: Adjunct to diet and exercise in type 2 diabetes, as initial therapy or as second-line therapy when response to a sulfonylurea or metformin is inadequate. Take with meals. First-line: initially 2.5mg/250mg once daily; or, if fasting plasma glucose is 280320mg/dL, may start at 2.5mg/500mg twice daily. May increase by 1 tab/day every 2 weeks; max 10mg/1000mg or 10mg/2000mg per day in divided doses. Second-line: (previously treated with sulfonylurea or metformin only): 2.5mg/500mg or 5mg/500mg twice daily (AM & PM) (initial dose should not exceed previous daily doses of individual components); may increase by increments of 5mg/500mg up to minimum effective dose or max 20mg/2000mg per day. Previously treated with combination therapy (sulfonylurea plus metformin): may be switched to 2.5mg/500mg or 5mg/500mg (initial dose should not exceed previous daily doses of individual components). Elderly: avoid max doses. Renal disease or dysfunction. Metabolic acidosis, diabetic ketoacidosis with or without coma. Concomitant intravascular iodinated contrast agents (suspend during and for 48hrs). Increased risk of cardiovascular mortality. Discontinue if lactic acidosis, shock, acute CHF, acute MI, sepsis, or hypoxemia occurs. Confirm normal renal function before starting therapy (esp. in patients 80yrs); monitor renal function. Avoid in hepatic disease. G6PD deficiency. Suspend before surgery that requires fasting. Monitor hematology (esp. serum Vit. B12 in susceptible patients). Elderly, debilitated, uncompensated strenuous exercise, malnourished, or deficient caloric intake, adrenal or pituitary insufficiency, alcohol intoxicat Continue reading >>
What Are The Possible Side Effects Of Glipizide And Metformin (metaglip)?
METAGLIP™ (glipizide and metformin HCl) Tablets 2.5 mg/250 mg 2.5 mg/500 mg 5 mg/500 mg DESCRIPTION METAGLIP™ (glipizide and metformin HCl) Tablets contain 2 oral antihyperglycemic drugs used in the management of type 2 diabetes, glipizide and metformin hydrochloride. Glipizide is an oral antihyperglycemic drug of the sulfonylurea class. The chemical name for glipizide is 1-cyclohexyl-3-[[p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl]sulfonyl]urea. Glipizide is a whitish, odorless powder with a molecular formula of C21H27N5O4S, a molecular weight of 445.55 and a pKa of 5.9. It is insoluble in water and alcohols, but soluble in 0.1 N NaOH; it is freely soluble in dimethylformamide. The structural formula is represented below. Metformin hydrochloride is an oral antihyperglycemic drug used in the management of type 2 diabetes. Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide monohydrochloride) is not chemically or pharmacologically related to sulfonylureas, thiazolidinediones, or α-glucosidase inhibitors. It is a white to off-white crystalline compound with a molecular formula of C4H12ClN5 (monohydrochloride) and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68. The structural formula is as shown: METAGLIP (glipizide and metformin) is available for oral administration in tablets containing 2.5 mg glipizide with 250 mg metformin hydrochloride, 2.5 mg glipizide with 500 mg metformin hydrochloride, and 5 mg glipizide with 500 mg metformin hydrochloride. In addition, each tablet contains the following inactive ingredients: microcrystalline cellulose, povidone, crosc Continue reading >>
What Is Glipizide / Metformin?
QUICK LINKS Oral route (Tablet) Lactic acidosis is a rare, but serious, metabolic complication that can occur due to metformin accumulation during treatment with glipiZIDE/metformin hydrochloride; when it occurs, it is fatal in approximately 50% of cases. The risk of lactic acidosis increases with renal impairment, increased age, diabetes mellitus, congestive heart failure, hepatic insufficiency, and other conditions whenever there is significant tissue hypoperfusion and hypoxemia. Treatment with glipiZIDE/metformin hydrochloride should not be initiated in patients 80 years of age or older unless measurement of creatinine clearance demonstrates that renal function is normal. Therapy should temporarily be discontinued prior to any intravascular radiocontrast study or surgical procedure. Avoid excessive alcohol use since alcohol potentiates the effects of metformin on lactate metabolism. Discontinue therapy immediately and institute supportive measures promptly for suspected lactic acidosis . Save up to 75% on Glipizide / Metformin Find big savings at pharmacies near you with GoodRx discount coupons Average Retail Price: $56.08 Lowest GoodRx Price $13.80 View All Prices Glipizide and Metformin combination is used to treat high blood sugar levels that are caused by a type of diabetes mellitus or sugar diabetes called type 2 diabetes. Normally, after you eat, your pancreas releases insulin to help your body store excess sugar for later use. This process occurs during normal digestion of food. In type 2 diabetes, your body does not work properly to store the excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future. Proper diet is the first step in managing type 2 diabetes but often medicines are needed Continue reading >>
How Glipizide Might Help With Your Type 2 Diabetes Management
Glipizide is an oral medication that is used to treat Type 2 diabetes. The drug is available in immediate-release tablets and extended-release tablets. Patients who currently take the medication as part of their diabetes treatment state that Glipizide has helped with lowering their blood sugar levels, and it seems that the extended-release tablets are favored over the immediate-release tablets. One of the main benefits from the drug is that it helps to lower your A1C levels by 1-2%. We will discuss the benefits and the downsides of Glipizide in more detail below. What is Glipizide? Glipizide is an oral medication used in the treatment of Type 2 diabetes. It is available in brand-name form as well as generic form, with the brand-names being Glucotrol and Glucotrol XL. Glipizide works by helping your pancreas produce more of your body’s natural insulin, which in turn regulates your blood sugar levels. Glipizide is used in conjunction with diet and exercise as part of a diabetes management plan. Glipizide is part of a class of diabetes drugs known as Sulfonylureas, which are designed to help your body’s pancreas to produce more of the body’s natural insulin. Diabetes medication aren’t designed to cure your Type 2 diabetes, but instead they are designed to treat the symptoms of diabetes, including blurry vision, excessive hunger, excessive thirst, frequent urination and sores that won’t heal. Further reading: Usually, the first diabetes medication that your doctor may prescribe is Metformin. However, many times, Glipizide is a popular choice for doctors to prescribe because many patients find that their bodies tolerate Glipizide better than Metformin. What are the Benefits of Glipizide? Glipizide can help lower your A1C levels by an average of 1-2%. Since Glipizid Continue reading >>
One Year Comparative Trial Of Metformin And Glipizide In Type 2 Diabetes Mellitus.
One year comparative trial of metformin and glipizide in type 2 diabetes mellitus. Diabetic Department, Victoria Hospital, Kirkcaldy, Fife, UK. Forty-eight diabetic subjects with diet-failed Type 2 mellitus, aged 40-69 years, were randomised to metformin (24 patients) or glipizide (24 patients) therapy, and followed prospectively for 12 months. Most subjects were obese. Metformin gave better fasting plasma glucose control compared to glipizide at 24 (p < 0.01), 36 (p < 0.05) and 52 weeks (p < 0.05) with a lower HbA1 concentration at 52 weeks (p < 0.05). Metformin treated patients lost weight whereas glipizide treated subjects gained weight. The weight change between the treatment groups reached significance at 4 weeks (p < 0.05) and was highly significant (p < 0.001) at 8, 12, 24, 36 and 52 weeks. There were no significant changes in either fasting plasma lipid or blood lactate levels in either the metformin or glipizide treated groups. Both drugs caused a similar reduction in albumin excretion rates. In conclusion, metformin gave better glycaemic control than glipizide, with weight loss rather than weight gain in obese Type 2 patients. Continue reading >>
Glipizide And Metformin
Generic Name: Glipizide and Metformin (GLIP i zide & met FOR min) Warning Rarely, metformin may cause an acid health problem in the blood (lactic acidosis). The risk of lactic acidosis is higher in people with kidney problems and in people who take certain other drugs like topiramate. The risk is also higher in people with liver problems or heart failure, in older people (65 or older), or with alcohol use. If lactic acidosis happens, it can lead to other health problems and can be deadly. Lab tests to check the kidneys may be done while taking glipizide and metformin. Talk with the doctor. Call your doctor right away if you have signs of too much lactic acid in the blood (lactic acidosis) like fast breathing, fast or slow heartbeat, a heartbeat that does not feel normal, very bad upset stomach or throwing up, feeling very sleepy, shortness of breath, feeling very tired or weak, very bad dizziness, feeling cold, or muscle pain or cramps. Do not take this medicine if you have a very bad infection, low oxygen, or a lot of fluid loss (dehydration). If you have liver disease, talk with your doctor. Talk with your doctor before you drink alcohol. If you are having an exam or test with contrast or have had one within the past 48 hours, talk with your doctor. Tell all of your health care providers that you take glipizide and metformin. This includes your doctors, nurses, pharmacists, and dentists. Uses of Glipizide and Metformin: It is used to lower blood sugar in patients with high blood sugar (diabetes). What do I need to tell my doctor BEFORE I take Glipizide and Metformin? If you have an allergy to glipizide, metformin, or any other part of this medicine. If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the Continue reading >>
Glipizide And Metformin
Pronunciation: GLIP ih zyd and met FOR min slide 1 of 9, Glipizide-Metformin 2.5 mg-250 mg-MYL, slide 2 of 9, Glipizide-Metformin 2.5 mg-250 mg-TEV, slide 3 of 9, Glipizide-Metformin 2.5 mg-500 mg-MYL, slide 4 of 9, Glipizide-Metformin 2.5 mg-500 mg-TEV, slide 5 of 9, Glipizide-Metformin 5 mg-500 mg-MYL, slide 6 of 9, Glipizide-Metformin 5 mg-500 mg-TEV, What is the most important information I should know about glipizide and metformin? You should not use glipizide and metformin if you have severe kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking glipizide and metformin. Some people taking metformin develop a serious condition called lactic acidosis. Stop taking this medicine and get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired. Glipizide and metformin is a combination of two oral diabetes medicines that help control blood sugar levels. Glipizide and metformin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes. This medicine is not for treating type 1 diabetes. Glipizide and metformin may also be used for purposes not listed in this medication guide. What should I discuss with my healthcare provider before taking glipizide and metformin? You should not use this medicine if you are allergic to glipizide or metformin, or if you have: metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment). If you ne Continue reading >>
Glipizide-metformin Side Effects
Glipizide and metformin is a combination of two oral diabetes medicines that help control blood sugar levels. Glipizide and metformin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes. This medicine is not for treating type 1 diabetes. Glipizide and metformin may also be used for purposes not listed in this medication guide. You should not use glipizide and metformin if you have severe kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking glipizide and metformin. Some people taking metformin develop a serious condition called lactic acidosis. Stop taking this medicine and get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired. You should not use this medicine if you are allergic to glipizide or metformin, or if you have: severe kidney disease; or metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking glipizide and metformin. To make sure glipizide and metformin is safe for you, tell your doctor if you have: kidney disease; congestive heart failure, especially if you take digoxin (Lanoxin) or furosemide (Lasix); a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency; liver disease; heart disease; or if you are over 80 years old and have not Continue reading >>
Glipizide And Metformin Overview
Glipizide/metformin is a prescription medication used in the management of type 2 diabetes mellitus. It is a single tablet containing 2 medications: glipizide and metformin. Glipizide belongs to a group of drugs called sulfonylureas. These work by stimulating the release of insulin from the pancreas. Metformin belongs to a group of drugs called biguanides. These work by decreasing the amount of glucose absorbed from food and decreasing the amount of glucose that is produced by the liver. This medication comes in tablet form and is taken once or twice daily with meals. Common side effects of glipizide/metformin include stomach pain, nausea or vomiting, diarrhea, and dizziness. Glipizide/metformin can also cause dizziness. Do not drive or operate heavy machinery until you know how glipizide/metformin affects you. Glipizide/metformin is a prescription medication used in the management of type 2 diabetes mellitus. It helps to lower the amount of glucose (sugar) in the blood. This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information. Continue reading >>
Metaglip, (glipizide-metformin) Dosing, Indications, Interactions, Adverse Effects, And More
Discontinue metformin at the time of or before an iodinated contrast imaging procedure in patients with an eGFR between 30-60 mL/minute/1.73 m; in patients with a history of liver disease, alcoholism, or heart failure; or in patients who will be administered intra-arterial iodinate contrast Characterized by elevated blood lactate levels (>5 mmol/L) Rare but serious complication that can occur because of metformin accumulation; increased risk with sepsis, dehydration, excess alcohol intake, hepatic insufficiency, renal impairment, and acute congestive heart failure Subtle onset with nonspecific symptoms (eg, malaise, myalgias, respiratory distress, somnolence, nonspecific abdominal distress) Monitor lab for decreased serum pH, increased anion gap, and elevated blood lactate If suspected, discontinue drug and hospitalize patient immediately Metformin is highly dialyzable (clearance up to 170 mL/min under good hemodynamic conditions); prompt hemodialysis is recommended to correct the acidosis and to remove accumulated metformin Severe renal disease: eGFR <30 ml/min/1.73 m Metabolic acidosis, diabetic ketoacidosis Rare but serious lactic acidosis can occur due to accumulation of metformin Patients with glucose-6-phosphate dihydrogenase deficiency may be at risk of sulfonylurea induced hemolytic anemia Discontinue metformin at the time of or before an iodinated contrast imaging procedure in patients with an eGFR between 30-60 mL/minute/1.73 m; in patients with a history of liver disease, alcoholism, or heart failure; or in patients who will be administered intra-arterial iodinate contrast Reevaluate eGFR 48 hr after the imaging procedure; restart metformin if renal function is stable Continue reading >>
Uses This diabetes medication is a combination of 2 drugs (glipizide and metformin). It is used along with a diet and exercise program to control high blood sugar in patients with type 2 diabetes. Glipizide is a sulfonylurea and works by stimulating the release of your body's natural insulin and by decreasing the amount of sugar that your liver makes. Metformin is a biguanide and works by decreasing the amount of sugar that your liver makes and that your stomach/intestines absorb. Both of these medications work by helping to restore your body's proper response to the insulin you naturally produce. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. How to use Glipizide-Metformin Read the Patient Information Leaflet available from your pharmacist before you start using this medication and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Take this medication by mouth, usually once or twice a day with meals or as directed by your doctor. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects (such as upset stomach), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. If you are already taking another diabetes drug (e.g., chlorpropamide), follow your docto Continue reading >>
Glipizide And Metformin (metaglip Has Been Discontinued In The Us)
are allergic to dapagliflozin or any of the ingredients in FARXIGA. Symptoms of a serious allergic reaction may include skin rash, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. If you have any of these symptoms, stop taking FARXIGA and contact your healthcare provider or go to the nearest hospital emergency room right away have severe kidney problems or are on dialysis. Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with FARXIGA Dehydration (the loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at a higher risk of dehydration if you have low blood pressure; take medicines to lower your blood pressure, including water pills (diuretics); are 65 years of age or older; are on a low salt diet, or have kidney problems Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with FARXIGA. Ketoacidosis is a serious condition which may require hospitalization and may lead to death. Symptoms may include nausea, tiredness, vomiting, trouble breathing, and abdominal pain. If you get any of these symptoms, stop taking FARXIGA and call your healthcare provider right away. If possible, check for ketones in your urine or blood, even if your blood sugar is less than 250 mg/dL Kidney problems. Sudden kidney injury occurred in people taking FARXIGA. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or excessive heat exposure Serious urinary tract infections (UTI), some that lead to hospitalization, occu Continue reading >>
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What Are Side Effects Of Glipizide-metformin?
Home / Type 2 Diabetes Questions / What are side effects of Glipizide-metformin? What are side effects of Glipizide-metformin? What are side effects of Glipizide-metformin 2.5mg/500mg I am currently taking? I take one tablet twice a day. An easy way to check this is to go to the sepalika home page, and right up there is the Drug Side Effect Tool. You just have to enter your drug name either brand name or, like in your case, just enter Glipizide and Metformin and click Get Solutions. This throws up the results page that shows the vitamins and nutrients depleted by long term use of metformin and glipizide. You can use this tool to test for different drugs, both for yourself or for friends and family. Long term use of metformin and glipizide can deplete Vitamin B12, Folic Acid and Coenzyme Q10. This can lead to a variety of side effects, from fatigue to tingling hands and legs, to memory and cognition issues, skin issues, mouth ulcers, muscle pains and cardiac issues (including irregular heart beat). Several dietary supplements have been proven to help with blood sugar control. You can see a full list of those here. There are medical doctors like Jason Fung, M.D. who now say that Type 2 diabetes is reversible; through intensive diet and lifestyle changes. You can read more about this here: Continue reading >>
What Are The Possible Side Effects Of Glipizide And Metformin (metaglip)?
A A A Medications and Drugs Brand Names: Metaglip Generic Name: glipizide and metformin (Pronunciation: GLIP ih zyd and met FOR min) What is glipizide and metformin (Metaglip)? Glipizide and metformin is a combination of two oral diabetes medicines that help control blood sugar levels. Glipizide and metformin is for people with type 2 diabetes who do not use daily insulin injections. This medication is not for treating type 1 diabetes. Glipizide and metformin may also be used for purposes not listed in this medication guide. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. This medication may cause lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time. Get emergency medical help if you have even mild symptoms of lactic acidosis, such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired. Stop taking this medication and call your doctor at once if you have a serious side effect such as: feeling short of breath, even with mild exertion, swelling or rapid weight gain; pain or burning with urination; nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure). Less serious side effects may include: cold symptoms such as stuffy nose, sneezing, sore throat; headache, dizziness; mild nausea, vomiting, diarrhea, st Continue reading >>
Description And Brand Names
Drug information provided by: Micromedex US Brand Name Metaglip Descriptions Glipizide and Metformin combination is used to treat high blood sugar levels that are caused by a type of diabetes mellitus or sugar diabetes called type 2 diabetes. Normally, after you eat, your pancreas releases insulin to help your body store excess sugar for later use. This process occurs during normal digestion of food. In type 2 diabetes, your body does not work properly to store the excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future. Proper diet is the first step in managing type 2 diabetes but often medicines are needed to help your body. With two actions, the combination of glipizide and metformin helps your body cope with high blood sugar. Glipizide stimulates the release of insulin from the pancreas, directing your body to store blood sugar. Metformin has three different actions: it slows the absorption of sugar in your small intestine; it also stops your liver from converting stored sugar into blood sugar; and it helps your body use your natural insulin more efficiently. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Tablet Copyright © 2018 Truven Health Analytics Inc. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Continue reading >>
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