Effectiveness Of Metformin On Weight Loss In Non-diabetic Individuals With Obesity.
Abstract OBJECTIVE: The efficacy of metformin for the treatment of obesity has been evaluated in few clinical trials with inconclusive results. Moreover, the effectiveness in a real-life outpatient setting has not been tested until today. In this study we aimed to examine the effectiveness of metformin as a weight reducing drug in obese and overweight patients with regard to their degree of insulin resistance. DESIGN AND PATIENTS: We treated 154 consecutive patients with a body mass index ≥27 kg/m(2) in an outpatient setting over 6 months with metformin up to a dosage of 2,500 mg per day. Additionally, we included 45 untreated patients as controls. Patients were monitored for weight changes over 6 months. Before metformin treatment was started insulin sensitivity was determined in all patients by calculating HOMA index and Matsuda index after a 75 g oral glucose tolerance test. RESULTS: The mean weight loss in the metformin treated group was 5.8±7.0 kg (5.6±6.5%). Untreated controls gained 0.8±3.5 kg (0.8±3.7%) on average. Patients with severe insulin resistance lost significantly more weight as compared to insulin sensitive patients. The percentage of weight loss was independent of age, sex or BMI. CONCLUSION: Metformin is an effective drug to reduce weight in a naturalistic outpatient setting in insulin sensitive and insulin resistant overweight and obese patients. © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York. Continue reading >>
Reducing My Dose Of Metformin (a Question)
Reducing My Dose of Metformin (A Question) Reducing My Dose of Metformin (A Question) I'm reducing my dose at my doctor's request. I've been on the new dose for a few days with no real change in my blood sugar. If my numbers are good, I'm supposed to go down another 500 milligrams. How much time should I give each amount? I know Metformin can take weeks and weeks to build up, but how long does it take to see the effects of a lower dose? D.D. Family Getting much harder to control Heck I have heard of up to a month but I know your doing great. Is this the doc that thinks your cured or whatever is that why there reducing the dose. I heard it can stay in your system for 5-6 weeks. What dose does your doctor want you on? My feeling is as long as my body tolerates the higher doses I am going to stick to it. In 5 years I've only had 1 or 2 numbers in the 60's and that was after I drank too much wine. 115 pounds, Breast Cancer dx'd 6/16, 6 months of chemo and 6 weeks of radiation 2000 metformin ER, 100 mg Januvia,Glimperide, Prolia, Gabapentin, Meloxicam, Probiotic with a Prebiotic, , Lisinopril, B-12, B-6, Tumeric, Magnesium, Calcium, Vit D, and Occuvite mostly vegan diet, low fat and around 125 carbs a day, walk 5-6 miles every other day and 1 hour of yoga and light weights. She wants me on no dose, but at our last appointment conceded that I may still need Metformin until I get down to my perfect weight. She even said, "You know... the fat is what caused the high blood sugar, so you probably won't need medication when you lose all the weight." Well, I'm less than 10 pounds off a normal BMI now and 20-25 pounds off my end goal (vanity weight), so I'm not so sure what cure I should expect in that time. I was on 2000 milligrams, I'm on 1500 now, and she would like me down to 1 Continue reading >>
High Dose Metformin Effect On Weightloss, Androgen Levels And Thyroid Function In Obese Hypothyroid Patients With Pcos
Endocrine Abstracts (2017) 49 EP1132 | DOI: 10.1530/endoabs.49.EP1132 High dose metformin effect on weightloss, androgen levels and thyroid function in obese hypothyroid patients with PCOS Aurelian-Emil Ranetti1,2 & Anca-Pati Cucu1 1Dr. Carol Davila Central University Emergency Military Hospital, Bucharest, Romania; 2Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. Objective: to evaluate the effects of metformin use on weight loss, improvement of ovarian and thyroid function in obese women with polycystic ovarian syndrome. Material and Methods: 30 obese (BMI 3034.99 kg/m2) hypothyroid (TSH 610 mIU/ml) women of age 2535 years old were included. The patients received appropriate levothyroxine treatment according to TSH levels and body weight. A number of 15 patients added metformin gradually increased from a starting dose of 500 mg/day to a final dose of 3000 mg/day over a period of 6 months. Baseline levels, 3 months and 6 months levels of TSH, fT4, T3, AMH, LH/FSH ratio, testosterone, along with BMI and ultrasound ovarian volume and antral follicle count were determined. No adverse events that might have led to discontinuation of the treatment were recorded. Mild nausea was registered in 8 patients after 2 weeks of treatment with 3000 mg/day of metformin, respectively softer stools (but no diarrhoea) in 5 patients in the first week of treatment (500 mg/day), but the symptoms relieved with disappearing within the mentioned time frame. Results: BMI levels decreased significantly in the first 3 months in metformin group (32.5+/-1.65 kg/m2 vs. 28.4+/ 1.95 kg/m2). BMI variation in the non met-group was smaller. BMI levels have reached a plateau after 3 months of metformin treatment. TSH levels decreased (7.2+/ 1.6 mUI/ml vs. 4.8+/2.2 mUI/ml) significant Continue reading >>
'can I Take Metformin If I Want To Lose Weight?'
'Can I Take Metformin If I Want To Lose Weight?' Some doctors are now prescribing this diabetes drug for weight loss. But is it safe? Metformin is a drug designed to treat patients with Type 2 diabetes, but it comes with an interesting side effect: weight loss . And Reddit is filled with stories from people who have lost weight on the drug. Was trying to lose weight for a long time with no success, one person wrote of being prescribed metformin. Im on 1000 mg a day and am down 10 pounds. I saw weight loss at first with 500 mg twice per day, another wrote. The difference was almost immediate. While some people say the drug didnt do much for them, others swear by iteven those that dont have Type 2 diabetes, saysFatima Cody Stanford, M.D., an instructor of medicine and pediatrics at Harvard Medical School and obesity medicine physician at Massachusetts General Hospital. In fact, Cody Stanford says that she often prescribes the medication to overweight or obese people who don't have Type 2 diabetes. Heres what you need to know about the drug. (Hit the reset buttonand burn fat like crazy with The Body Clock Diet !) Metformin causes a decrease in the release of glucose from a persons liver. This helps to lower a persons blood sugar when its too high and restore the way someone uses food to make energy, according to the Mayo Clinic . " Weight loss can occur because it decreases appetite in some people who take it," says women's health expert Jennifer Wider , M.D. In order for the prescription to work effectively, the amount of metformin you take must be balanced against your diet and exercise because it helps level out your blood sugar, the clinic says. For that reason, if you change your diet or exercise, you doctor may need to change the amount of metformin you take. Check Continue reading >>
There have been no human studies to identify the optimal dose of metformin that is needed to duplicate the beneficial gene expression effects that are described in the June 2003 issue of Life Extension magazine . For people who want to derive the many proven health benefits of metformin, it might be prudent to follow the dosage schedule used by Type II diabetics. According to the Physician's Desk Reference, the starting dose should be 500 mg of metformin twice a day. (An alternative option is 850 mg of metformin once a day). After one week, increase the dose of metformin to 1000 mg as the first dose of the day and 500 mg as the second dose. After another week, increase to 1000 mg of metformin two times a day. The maximum safe dose described in the Physician's Desk Reference is 2550 mg a day (which should be taken as 850 mg three times a day). According to the Physician's Desk Reference, clinically significant responses in Type II diabetics are not seen at doses below 1500 mg a day of metformin. Anti-aging doctors, on the other hand, have recommended doses as low as 500 mg twice a day to healthy non-diabetics who are seeking to obtain metformin's other proven benefits such as enhancing insulin sensitivity and reducing excess levels of insulin, glucose, cholesterol and triglycerides in the blood. It could be the dosage range is highly individualistic in healthy people, meaning some may benefit from 500 mg twice a day, while others may need 1000 mg twice a day for optimal effects. Blood tests to ascertain if the dose of metformin you are taking is improving glucose/insulin metabolism would be: Continue reading >>
Everything You Always Wanted To Know About Metformin, But Were Afraid To Ask
Everything You Always Wanted to Know About Metformin, But Were Afraid to Ask Starting on metformin? My journey as a type 2 of learning how to deal with side effects, faux lows, and learning more about this therapy Editors note: this article is in Marcias perspective of living with type 2 diabetes, as written by Timothy Hay When I was first diagnosed with type 2 diabetes at the age of 58, my doctor immediately put me on metformin, a medication I didnt know much about. I soon learned why metformin is considered the first line of defense for people with the condition, as it is safe, effective, and affordable. Its not linked to weight gain and it puts very little stress on the internal organs. I also read that metformin has side effects for some people. I expected it to work like insulin in pill form and drop my blood sugar (around 180 mg/dl at the time) right away. But metformin doesnt work like that. Not at all. I learned as millions of people with type 2 diabetes have that metformin doesnt immediately lower your blood sugar. It can take four or five days to experience the full benefit, depending on your dosage. It might not solve all your problems in the blink of an eye. But it is an effective medicine, and its interaction with the body is complex and interesting. Metformin, which is also sold under the trade names Glucophage, Fortamet, Glumetza, and Riomet, is of the class of drugs called biguanides, which inhibit the production of glucose in the liver. The medicine does not increase insulin levels in the body, but instead lessens the amount of sugar the body produces and absorbs. As it lowers glucose production in the liver, metformin also lowers blood sugar by increasing the bodys sensitivity to insulin. It also decreases the amount of glucose that our bodies absorb Continue reading >>
Why Metformin (glucophage) Causes Weight Loss And Reduced Appetite Despite Stimulating Ampk?
In regard to weight loss, Metformin provides two primary benefits. First, it significantly improves glycemic control. This stabilizes your blood sugar, and makes you less likely to experience the up-and-down rollercoaster experience that often comes along with dieting. The second benefit of Metformin (partially a result of the first benefit) is suppressed appetite. Users typically note a measurable improvement from their usual cravings for food. By simply not desiring as much food, and still feeling normal despite eating less (due to the improved glycemic control), the result can be profound weight loss. That’s the good news, but you can’t just take the pill and expect everything to change on its own. Weight loss just doesn’t work that way. Metformin won’t work for you – rather, it will work with you. Continue reading >>
Metformin Dosage There have been no human studies to identify the optimal dose of metformin that is needed to duplicate the beneficial gene expression effects that are described in the June 2003 issue of Life Extension magazine. For people who want to derive the many proven health benefits of metformin, it might be prudent to follow the dosage schedule used by Type II diabetics. According to the Physician's Desk Reference, the starting dose should be 500 mg of metformin twice a day. (An alternative option is 850 mg of metformin once a day). After one week, increase the dose of metformin to 1000 mg as the first dose of the day and 500 mg as the second dose. After another week, increase to 1000 mg of metformin two times a day. The maximum safe dose described in the Physician's Desk Reference is 2550 mg a day (which should be taken as 850 mg three times a day). According to the Physician's Desk Reference, clinically significant responses in Type II diabetics are not seen at doses below 1500 mg a day of metformin. Anti-aging doctors, on the other hand, have recommended doses as low as 500 mg twice a day to healthy non-diabetics who are seeking to obtain metformin's other proven benefits such as enhancing insulin sensitivity and reducing excess levels of insulin, glucose, cholesterol and triglycerides in the blood. It could be the dosage range is highly individualistic in healthy people, meaning some may benefit from 500 mg twice a day, while others may need 1000 mg twice a day for optimal effects. Blood tests to ascertain if the dose of metformin you are taking is improving glucose/insulin metabolism would be: Hemoglobin A1c Fasting insulin CBC/Chemistry panel that includes glucose, cholesterol triglycerides and indicators of liver and kidney function A hemoglobin A1c test Continue reading >>
Must I Increase My Dose Of Metformin To Lose Weight?
Weight loss is an integral aspect of improving Polycystic Ovarian Syndrome, or PCOS, in women who are overweight. Carrying extra weight can cause the condition’s symptoms to become more severe, and can even increase the level of Insulin Resistance (IR) that a woman experiences.1 IR occurs when the body’s cells become desensitized to insulin, preventing the hormone from turning glucose into energy. This results in high blood sugar and, in some cases, diabetes. For this reason, Metformin, a popular diabetes medication, is also used to improve PCOS. Aside from regulating blood sugar levels, this pharmaceutical, also known as Glucophage, contributes to weight loss. How Metformin Encourages PCOS Weight Loss Insulin is a hormone that triggers both hunger and the production of fat cells. Therefore, by reducing insulin, women can reduce the amount of food they eat as well as the amount of fat cells that their bodies produce.2 Metformin’s primary function is to reduce insulin, so it is only natural that this medication contributes to weight loss. How Much Medication Is Necessary? Dosage is determined by several factors; healthcare professionals consider medical history, body type, and severity of symptoms when coming to the proper dosage. Metformin comes in three different sized pills: 500 mg, 850 mg, and 1,000 mg.2 Generally, individuals are prescribed between 850 and 1,000 mg two times per day, with 850 mg three times per day being the maximum amount of the medication safe to consume.2 Typically, doctors will prescribe a low dose to gauge the body’s reaction to the medication.2 If the body needs more, physicians will alter the dosage until the right amount is achieved. Because so many factors contribute to the proper dosage, many women who are prescribed different amou Continue reading >>
Does Reduction Of Metformin Dose Cause Weight Gain?
Does reduction of Metformin dose cause weight gain? Does reduction of Metformin dose cause weight gain? When I went to see my doctor last week of April, my weight was 162. It came down from 190 to 162 during December - April. He did not seem to be comfortable seeing my lean body. He reduced Met dose from 1000mg to 500mg per day saying that the small dose is good enough for my current A1C 5.7. I wonder whether my rapid weight loss influenced his decision to reduce Met dose. For almost a month, I have been on Metformin 500 mg per day. Now, I noticed that my weight went up by about 6 pounds. Fortunately, BG levels continue to improve in spite of weight gain and reduction in Met. I do not know whether I increased my food consumption unknowingly. Can reduction in Metformin dose increase body weight? D.D. Family T2 for 24 years, pumping 3/07/07,no complications Both 1000 and 500 are small doses, 850 x 3 is the maximum dose. While there might be some difference in how it affects your weight, IMHO the difference would be slight. Hi Lloyd, I wonder whether my weight is very sensitive to Metformin. I am going to carefully watch what I will eat in order to rule out the possibility of increased food consumption. Met is supposed to help with weight loss. I am about the weight you were last Dec, and take 2-500mg Met ER daily... Met is supposed to help with weight loss. Yes, I personally experienced it within the first month of treatment with Metformin. It killed my appetite initially. It is truly a wonderful drug for diabetes if body can accept it. The only way to be sure is to carefully measure what you eat. This is the only way I was able to lose weight and get past a plateau. I'm hopeless at judging carb and protein content of food by looking at it, so I measure all my food and e Continue reading >>
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Metformin 850mg Tablets
1. WHAT METFORMIN IS AND WHAT IT IS USED FOR The name of this medicine is Metformin 500mg or 850mg Tablets (called metformin in this leaflet). It belongs to a group of medicines called biguanides (a type of oral hypoglycaemic). Metformin is used for the sort of diabetes called Type 2 diabetes or non-insulin-dependent diabetes mellitus. In type 2 diabetes, there is too much sugar (glucose) in your blood. This is because your body does not make enough insulin or because it makes insulin that does not work properly. Insulin is a hormone that allows your body tissue to take glucose from the blood and use it for energy or for storage for future use. Metformin works by improving the sensitivity of your body to insulin. It helps your body to use glucose in the normal way again This medicine is given when diet and exercise alone has not been able to control your blood sugar levels. Metformin can be given on its own. However, sometimes it is given with other medicines for diabetes or with insulin. In patients who are overweight, long-term use of metformin also helps to lower the risk of any problems related to diabetes you are allergic (hypersensitive) to metformin or any of the other ingredients in this liquid (see section 6: Further information). An allergic reaction can include a rash, itching or shortness of breath. you have recently had a heart attack or any other heart problems you have severe circulation problems or difficulty in breathing you have had serious problems with your diabetes in the past called diabetic ketoacidosis. When you have this you lose weight quickly, feel sick (nausea) or are sick (vomiting). See also in Section 4: Possible side effects you have recently had a severe infection, injury or trauma (shock) you are going to have an X-ray where you will b Continue reading >>
Reducing Dosage Of Metformin
Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community This is my first time posting, so I hope I am doing it correctly! I was diagnosed as type 2 in September 2013 with an Hba1c of 11 and cholesterol of 5.2. I went through the usual feelings of disbelief, self-blame and shame and it took me several months to come to terms with it. I was prescribed 4 x 500mg metformin and 40mg of Simvastatin. I suffered with severe diarrhoea on the Metformin and asked to go on slow release (thanks to the information on the forum) and that settled down although it hasnt gone completely. I cheated with the statins as I wanted to try and affect the figures with diet and exercise and so I cut the tablet in half and only took 20mg My results in December showed blood sugars down to 6.1 and cholesterol down to 2.9. It was agreed after much discussion that I could reduce the statins down to 10mg. I have just had my second 3 monthly check and the blood sugars are down to 5.7 and cholesterol still at 2.9. I am very strict with my diet and I am low carbing as well as avoiding sugars and exercising. I have lost almost 2 stone and my BMI is now 26. Sorry for long the preamble my question is: I know I will have diabetes for life but wondered if being on such a high dose with my figures as they are now gives me nowhere to go if things deteriorate as I get older (I am 62). Does anyone have any experience of reducing the Metformin my DN says I can try it if I want to! Also I would like to stop taking the statins. Your thoughts would be really appreciated. I have found the forum very informative and very supportive. Thank you. I was diagnosed in November and I reduced my hba1c from 115 then to 52 mid February. I test a lot and my bg readin Continue reading >>
Metformin For Weight Loss How It Works, Benefits, And Side Effects
For adults, Metformin tablets can be taken 2-3 times a day. For children and teenagers, 1 Metformin tablet per day is recommended. It is not allowed for children under 10 years of age. The maximum daily dose is 1000 3000 mg metformin per day (divide the doses into 2 or 3 smaller doses). Your doctor will start with the lowest dose, and after a week or two, depending on your bodys response to the previous dose, he/she may increase the dose. Do not stop taking it until your doctor tells you to do so. But, what happens if you miss a dose? Find out next. You should be extra careful when you take Metformin for weight loss. There is nothing to worry about if you miss a dose. However, if you remember it very close to the time for your next dose, do not take the pill. If not, you can safely take the missed dose as soon as possible. Make sure to eat something along. Metformin overdose can be fatal. Do not try to take too many pills to lose weight quickly. Overdosing yourself will not lead to weight loss, but you may experience fast breathing, chills, stomach ache, nausea, headache, and lactic acidosis. Make sure to go to your nearest hospital to get help. Now, the next big question is, how much weight loss can you expect and in how much time. Lets find out. How Much Weight Loss Is Expected From Metformin? There have been many studies regarding Metformin-induced weight loss in type 2 diabetic patients and obese people. Many of these studies lasted from 4 to 7 months. The results concluded that the immediate weight loss experienced due to Metformin ranged from 1 to 4 kg. Experts say that the real weight reduction begins only after taking the medication for 4 to 6 weeks in total. So, is it really safe to take Metformin for such a long period for weight loss? Find out in the next se Continue reading >>
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Metformin Weight Loss – Does It Work?
Metformin weight loss claims are something that are often talked about by health professionals to be one of the benefits of commencing metformin therapy, but are they true? At myheart.net we’ve helped millions of people through our articles and answers. Now our authors are keeping readers up to date with cutting edge heart disease information through twitter. Follow Dr Ahmed on Twitter @MustafaAhmedMD Metformin is possibly one of the most important treatments in Type II Diabetes, so the question of metformin weight loss is of the utmost importance, as if true it could provide a means to lose weight as well as control high sugar levels found in diabetes. What is Metformin? Metformin is an oral hypoglycemic medication – meaning it reduces levels of sugar, or more specifically glucose in the blood. It is so effective that the American Diabetes Association says that unless there is a strong reason not to, metformin should be commenced at the onset of Type II Diabetes. Metformin comes in tablet form and the dose is gradually increased until the maximum dose required is achieved. How Does Metformin Work & Why Would it Cause Weight Loss? Metformin works by three major mechanisms – each of which could explain the “metformin weight loss” claims. These are: Decrease sugar production by the liver – the liver can actually make sugars from other substances, but metformin inhibits an enzyme in the pathway resulting in less sugar being released into the blood. Increase in the amount of sugar utilization in the muscles and the liver – Given that the muscles are a major “sink” for excess sugar, by driving sugar into them metformin is able to reduce the amount of sugar in the blood. Preventing the breakdown of fats (lipolysis) – this in turn reduces the amount of fatt Continue reading >>
Metformin Side Effects: What You Need To Know
Metformin Side Effects: What You Need to Know Metformin is one of the most prescribed drugs on the planet with over 120 million people taking it for diabetes management, but that doesnt mean its the most popular. Unfortunately, metformin also has one of the lowest patient adherence rates, because of its side effects which can appear within hours of taking your first dose. While there are actually many positive qualities about this drug compared to other diabetes medications, metformin side effects can be remarkably uncomfortable, disrupting your daily life. In this article, well look at how metformin works, the most common side effects, how to alleviate those side-effects, and why its the most prescribed despite causing so much discomfort for patients. Metformin, also known under the brand name Glucophage, is an oral diabetes medication in the biguanide drug class , first introduced in 1957 to treat type 2 diabetes and improve blood sugar control. It works by reducing the amount of sugar your liver releases throughout the day, and it increases your bodys sensitivity to insulin. It can also reduce the amount of glucose that is absorbed from the food you eat, which in turn reduces your blood sugar levels after eating. Metformin is often considered the first line of defense for a patient newly diagnosed with type 2 diabetes, explains the American Diabetes Association. The biggest benefit of metformin is the fact that it doesnot directly cause hypoglycemia;however when paired with other diabetes medications that do lower blood sugar, metformin could result in low blood sugar until those other medication doses are reduced to compensate. Here are all of the known benefits of metformin: It reduces the amount of glucose produced by your liver It reduces the amount of glucose a Continue reading >>