Metformin Hcl Er Osm
Metformin Vs Metformin (mod Vs Osm): What’s The Difference?
Metformin and extended release metformin are used in type 2 diabetes to improve glycemic control in combination with diet and exercise. What are the advantages of extended release metformin? The extended release tablets are taken ONCE DAILY due to their slow release of the medication throughout the day. Extended release tablets are also easier on the stomach which is important for compliance when first starting a new medication. Fortamet and Glumetza are both extended release metformin options, but because the way they release metformin over time is different, they aren’t equivalent to each other. Glumetza is the MOD metformin product. So what does MOD stand for? MOD stands for modified release. Glumetza utilizes advanced polymer delivery technology known as AcuForm® (for the 500 mg tablet) and Smartcoat® (for the 1000 mg tablet). It delivers the metformin to the site of absorption, the duodenum, over a time span of 8 – 9 hours. The tablet then remains in the stomach for an extended period until all of the active drug is released. Does Glumetza have a generic? No. Glumetza does not currently have a substitutable generic equivalent. What is the MAX dose and available strengths of Glumetza? Glumetza comes in 500 mg and 1000 mg extended release tablets, with a max dose of 2000 mg per day. Fortamet is the OSM metformin product. So what does OSM stand for? OSM stands for osmotic release. Fortamet (and its generic equivalents) use single-composition osmotic technology. When you swallow the tablet, water is taken up through the membrane of the pill, which in turn dissolves the drug in the core so it can exit through the laser drilled ports in the membrane. The rate of drug delivery is constant, and will continue as long as there is undissolved drug present in the core ta Continue reading >>
Metformin Pricing Starting At $4.00. Find Your Pharmacy's Price.
Drug: METFORMIN Strength: 500 MG Quantity: 60 (sorted by best current price) METFORMIN is a generic drug found in the biguanides class and it typically, though not always, is prescribed by family medicine physicians and healthcare providers. METFORMIN costs at your pharmacy using this discount card, or coupon, recently started as low as $4.00 for the most commonly prescribed 500 MG strength and 60 count. Use the card whenever insurance is not available for your drugs. Even if you have insurance, when it does not cover your prescription you can use the coupon. There are no limits and it never expires. It works at over 65,000 pharmacies in the United States, Puerto Rico, the U.S. Virgin Islands and Guam. How does that work? Your pharmacy will occasionally use our discount as the basis for a one-time price adjustment in your favor. Our discounts are aggressive but if the pharmacy is able to beat our price then you benefit by getting an even bigger discount * - Pricing is based recent price paid for this drug, strength and quantity at a retail pharmacy. Prices are subject to change without notice. Take your card to the pharmacy counter to get your exact drug price. ** - That's right it is FREE to use; you pay nothing extra at the pharmacy. But if you want to learn more about ALL discount coupons and how they work, see our FAQ . - Prescription pet medications that are also approved by the FDA for human use are available for use with this discount card at your local pharmacy. - Note that Target Pharmacies are now operated by CVS and pricing may have changed recently. Continue reading >>
Is "metaformin Osm Er" The Same As Fortamet?
Home Q & A Questions Is "Metaformin OSM ER" the... Is "Metaformin OSM ER" the same as Fortamet? Yes, Fortamet contains the drug metformin ... so both these products contain the same ingredient and both are extended release formulations. However, different brands of extended release tablets may have slightly different release profiles so please confirm with your doctor//pharmacist whether these two products are interchangeable. Still looking for answers? Try searching for what you seek or ask your own question . The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices. Subscribe to receive email notifications whenever new articles are published. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated Feb 28th, 2018), Cerner Multum (updated Mar 1st, 2018), Wolters Kluwer (updated Mar 1st, 2018) and others. To view content sources and attributions, please refer to our editorial policy . Continue reading >>
Information On Metformin Hcl Er 500 Mg For Weight Loss
If you have high blood glucose levels, you may take metformin hydrochloride, an oral anti-hyperglycemic medication that lowers blood sugar. Metformin may also help you lose weight in some cases by decreasing your appetite. Clinical studies have not proven that metformin helps you lose weight if you don't have Type 2 diabetes or other metabolic disorders that cause insulin resistance. It may help prevent weight gain or cause modest weight loss if you're taking antipsychotic drugs that cause weight gain. Metformin comes in several doses, including a 500-milligram extended release form, which you may find easier to take. Video of the Day Metformin might help you lose weight if you have metabolic syndrome or polycystic ovary disease, both associated with insulin resistance. The pancreas releases insulin in response to glucose in your bloodstream. Insulin helps cells remove glucose from the bloodstream. When you eat large amounts of high-carb foods, the pancreas may overproduce insulin to keep up. Eventually, your cells stop responding to the insulin and your blood glucose levels rise. Because your cells feel starved for energy, you feel hungry all the time and may crave carbohydrates. Metformin helps cells respond better to insulin, so you don't feel as hungry. Insulin can also cause your liver to convert extra calories to fat. Metformin decreases the amount of glucose your liver produces, and also decreases the amount of glucose absorbed in your intestines. Decreased amounts of glucose in your bloodstream results in less glucose absorbed by your cells. When you absorb less glucose, you lose weight. An Indian study published in the March 2011 "British Journal of Clinical Pharmacology" reported that metformin increased weight loss in people taking olanzapine, an antipsychoti Continue reading >>
What Is The Difference Between Different Metformin Formulations?
Our pharmacist answers the latest question regarding the difference between the different formulations for metformin. What is the difference between Fortamet XR and Glumetza - Aren't they both metformin extended release? Answer You are right that both of the products that you mentioned are metformin. They differ in their release mechanism. All of the products are similar in the fact that they are extended release. The whole point of these extended release products is to reduce the gastrointestinal side effects that many patients experience when taking metformin. There are 3 different types of metformin extended release formulations: Glucophage XR This metformin product uses what is called a "dual hydrophilic polymer system" as its release mechanism. The outer layer of the tablets contain no drug at all. It's purpose is to completely surround inner polymer particles containing metformin. After the tablet is taken by mouth, the tablet absorbs moisture. In fact, hydrophilic means "water loving". The absorbed moisture causes the tablet to swell forming a gel layer on the outside of the tablet. It is this newly formed gel layer that releases metformin into the body at a controlled rate. It is intended to be dosed once daily. The peak concentrations of metformin in the body using the dual hydrophilic release polymer mechanism usually ranges anywhere from 4-8 hours. It is recommended to take this product with food as it increases the amount of drug that is absorbed in the body. Fortamet This metformin product uses single-composition osmotic technology. This technology is somewhat similar to what is used in the Glucophage XR tablets. Metformin is contained inside a semi-permeable membrane inside the tablet. The tablet contains two laser drilled holes on either side. When Continue reading >>
Metformin Er 1,000 Mg Tablet,extended Release 24hr
Rarely, too much metformin can build up in the body and cause a serious (sometimes fatal) condition called lactic acidosis. Lactic acidosis is more likely if you are an older adult, if you have kidney or liver disease, dehydration, heart failure, heavy alcohol use, if you have surgery, if you have X-ray or scanning procedures that use iodinated contrast, or if you are using certain drugs. For some conditions, your doctor may tell you to stop taking this medication for a short time. Ask your doctor or pharmacist for more details.Stop taking this medication and get medical help right away if you have any symptoms of lactic acidosis, such as unusual tiredness, dizziness, severe drowsiness, chills, blue/cold skin, muscle pain, fast/difficult breathing, slow/irregular heartbeat, or stomach pain with nausea/vomiting/diarrhea. Metformin is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. It is used in patients with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Metformin works by helping to restore your body's proper response to the insulin you naturally produce. It also decreases the amount of sugar that your liver makes and that your stomach/intestines absorb. This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.Metformin may be used with lifestyle changes such as diet and exercise to prevent d Continue reading >>
The Hugely Inflated Prices Of Glumetza And Metformin Er
I have been taking metformin (Glucophage) for about three years. My doctor recommended it since my A1c reading had been climbing from about 5.5 to 6.3% over a two-year period. There is also a history of Type 2 diabetes on the paternal side of my family. Metformin caused me some stomach upset so I switched to Glumetza, a coated form of the same drug, Glucophage, a standard treatment for diabetes that has been available in the United States since 1995. I have excellent insurance coverage and receive all my medications in the most economical form, three month prescriptions delivered by mail. On February 6th, Caremark mail service called to tell me there was a prescription coming for which I would have to sign. I told the caller that it was fine to leave it at the door. The Caremark representative said that was not possible since it was a high-value prescription. The prescription came the next day, I signed for it, and I checked the invoice only because the person on the phone had told me it was a “high-value prescription” and I knew it was only metformin. When I looked at the bottom of the invoice I noticed that the listed price was $14,020.87. My co-pay was $40.00 I called Caremark to tell them about the computer error. I didn’t think it was possible that metformin cost $14,020.87. I was even more certain that this was a computer error because the prescription was not Glumetza, but a generic, metformin ER. It was no error. And it was a generic prescription. The brand name Glumetza, sold for over $16,000 for a three-month supply. I was even more stunned than angry and I began to check around. I was about seven months late to the Glumetza story. Probably many of you followed the sale of Glumetza in 2015 to the now notorious Valeant Pharmaceuticals. By the time I reach Continue reading >>
Rxproduct News Profile: Fortamet Er (metformin Hydrochloride)
Background Type 2 diabetes (formerly known as non?insulin-dependent diabetes or adult-onset diabetes) commonly begins as insulin resistance, with cells using insulin incorrectly. Gradually, the pancreas loses its ability to produce insulin. According to the National Institutes of Health, 18.2 million Americans (6.3% of the US population) have diabetes.1 Type 2 diabetes accounts for ~90% to 95% of all diabetes. This disease is associated with obesity, a family history of diabetes, older age, and physical inactivity. Type 2 diabetes also is more prevalent among African Americans, Hispanic/Latino Americans, American Indians, and some Pacific Islander and Asian Americans. Type 2 diabetes has been treated with several antihyperglycemic drugs. Metformin, used for almost 50 years, has been shown to reduce all-cause and diabetes-related mortality and macrovascular disease risk.2 Fortamet (metformin hydrochloride) Extended-Release (ER) Tablets, marketed by Andrx Laboratories, are a new once-daily formulation. Pharmacology Metformin, a biguanide, acts by decreasing hepatic glucose production, decreasing intestinal absorption of glucose, and improving insulin sensitivity by increasing peripheral glucose uptake and utilization. Fortamet ER uses a single-composition osmotic technology (SCOT), consisting of an osmotically active core formulation surrounded by a semipermeable membrane. Two laser-drilled holes on either side of the tablet enable the drug to exit the tablet at a constant rate.3 Absorption is increased by ~60% when the drug is taken with food. The half-life is approximately 5.4 hours, and ~90% of the drug is renally eliminated within the first 24 hours. Clinical Trials A double-blind, randomized, active?controlled study of a total of 680 patients compared Fortamet ER wit Continue reading >>
Metformin Hydrochloride: Oral Tablet, Extended Release (500mg)
What is this Medicine? METFORMIN (met FOR min) is used to treat type 2 diabetes. It helps to control blood sugar. Treatment is combined with diet and exercise. This medicine can be used alone or with other medicines for diabetes. Generic 94.28%Brand 5.72% *Brand contains same active ingredient but may not represent FDA-approved generic equivalent 750mg1000mg500mg Ingredients Close All Sections Reported Side Effects for Metformin Hydrochloride 500mg Extended-Release Tablet Close Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine. Close All Interactions Close If you use tobacco or are trying to quit tobacco use, you may need to monitor your blood sugar more frequently. Nicotine, a component of tobacco, can increase the blood sugar. Also, if you are trying to quit smoking, as your body adjusts to not smoking, your blood sugar levels may change; the actions of Antidiabetic Agents (medicines used to treat diabetes) may be increased and this could lead to low blood sugar. Know the symptoms of low or high blood sugar and report them if they occur. Monitor your blood sugar regularly. Close Class B - Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women. OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester. Class B - Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women. OR Animal studies have shown an adver Continue reading >>
What's Going On With This Drug Price? : Pharmacy
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Drug information provided by: Micromedex This medicine usually comes with a patient information insert. Read the information carefully and make sure you understand it before taking this medicine. If you have any questions, ask your doctor. Carefully follow the special meal plan your doctor gave you. This is a very important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed. Metformin should be taken with meals to help reduce stomach or bowel side effects that may occur during the first few weeks of treatment. Swallow the extended-release tablet whole with a full glass of water. Do not crush, break, or chew it. While taking the extended-release tablet, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about. Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid. Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way. You may notice improvement in your blood glucose control in 1 to 2 weeks, but the full effect of blood glucose control may take up to 2 to 3 months. Ask your doctor if you have any questions about this. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the Continue reading >>
Toxicity limited prior use ( Lactic Acidosis ) Metformin has not demonstrated increased Lactic Acidosis risk Used in medieval Europe for Diabetes Mellitus Decreases hepatic Glucose production (gluconeogenesis) Increases peripheral Glucose uptake (sensitizes peripheral tissue to Insulin ) First line agent in Type II Diabetes Mellitus High Fastin g Blood Glucose 160-250 mg/dl Reduce Metformin dose to half if GFR 30-50 ml/min Avoid if Serum Creatinine >1.5 mg/dl in men and >1.4 mg/dl in women Avoid concurrent IV Iodinated Contrast Dye use Confirm normal Renal Function tests after dye Large review found no associated increased risk of Lactic Acidosis Maximum daily dose of Metformin is 2500 mg (for either regular or XR) Dose related drop in Fastin g Blood Glucose Metformin 500 mg decreases Fastin g Blood Glucose by 19 mg/dl Metformin 1000 mg decreases Fastin g Blood Glucose by 31 mg/dl Metformin 1500 mg decreases Fastin g Blood Glucose by 41 mg/dl Metformin 2000 mg decreases Fastin g Blood Glucose by 78 mg/dl Metformin 2500 mg decreases Fastin g Blood Glucose by 62 mg/dl Example 1: 1000 mg orally qAM and 500 mg orally qPM Increase by 500 mg weekly until at 2000 mg or at goal Blood Sugar Most cost-effective agent in the Type II Diabetes Mellitus arsenal of medications Avoid Glumetza (nearly $7000 extended release Metformin) Gastrointestinal side effects (up to one third of patients) Expect gastrointestinal adverse effects to be transient (days to weeks) Slow titration from 500 mg daily (or 250 mg) up to 2000 mg over 1-2 months Extended release formulations have less adverse effects (and may be divided twice daily) See Vitamin B12 Deficiency for management Consider periodic screening every 2-3 years in higher risk patients Check serum B12 when Peripheral Neuropathy occurs (do Continue reading >>
Metformin Hydrochloride: Oral Tablet, Extended Release (1000mg)
What is this Medicine? METFORMIN (met FOR min) is used to treat type 2 diabetes. It helps to control blood sugar. Treatment is combined with diet and exercise. This medicine can be used alone or with other medicines for diabetes. Generic 94.28%Brand 5.72% *Brand contains same active ingredient but may not represent FDA-approved generic equivalent 750mg1000mg500mg Ingredients Close All Sections Reported Side Effects for Metformin Hydrochloride 1000mg Extended-Release Tablet Close Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine. Close All Interactions Close If you use tobacco or are trying to quit tobacco use, you may need to monitor your blood sugar more frequently. Nicotine, a component of tobacco, can increase the blood sugar. Also, if you are trying to quit smoking, as your body adjusts to not smoking, your blood sugar levels may change; the actions of Antidiabetic Agents (medicines used to treat diabetes) may be increased and this could lead to low blood sugar. Know the symptoms of low or high blood sugar and report them if they occur. Monitor your blood sugar regularly. Close Class B - Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women. OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester. Class B - Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women. OR Animal studies have shown an adve Continue reading >>
Metformin Vs Metformin Er
I'm seeing quite a few posts on BBSes from people who are having problems with metformin because of side effects that could be eliminated if they were taking the extended release form of this drug. For some reason, many family doctors don't seem to be aware that there is a ER version of this drug that has such benefits. This is probably because metformin is a cheap generic and isn't promoted by herds of beautiful ex-cheerleaders turned drug company salespushers who "educate" doctors about far more expensive--and less effective--newer drugs. Here are the facts: Metformin (also sold under the brand name Glucophage) comes in a regular version which is taken at meal time, three times a day, and an extended release form (marketed as ER or XR) which is taken once a day. Almost always, when people report diarrhea or intense heartburn with metformin, they are taking regular version. I experienced the heartburn on the regular drug. It was very disturbing because the pain was localized over my heart and felt just like the description of a heart attack you read in articles. My doctor assured me it was coming from the metformin, but that didn't make it any easier to live with because I kept wondering how, if I were having a real heart attack, I'd know it wasn't a pain from the drug? The ER version releases the drug more slowly and this usually eliminates the gastrointestinal problems. The trade off with taking the ER form is that the amount of blood sugar lowering you see might be a bit less than with the regular form as the drug acts in a slower smoother fashion rather than hitting all at once. But if you can't take the regular at all drug because of the side effects, the slight weakening in effect is a reasonable trade off. Plus, you only have to remember to take one dose rather Continue reading >>