Metformin, The Safe, Boring, Extremely Cheap Drug, That Could Have An Effect On Aging - Longevity
Metformin, the safe, boring, extremely cheap drug, that could have an effect on aging Its happening. Its happening, but its frustrating how long it takes, he says. This is possible, but we need to start it everywhere we can and not let another generation be affected by aging without health. Exciting stuff, at least for the long term implications. As a young person I feel pretty sanguine about the whole research process, but I'd be freaking out about the pace of this stuff if I were a few decades older. Michael Rae of the SENS RF takes a very dim view of the metformin research that has been done in mice so far. Given that caloric restriction from birth provides f all life extension in monkeys, a CR mimetic in humans from middle age will provide... 4 months life extension?? Youd honestly be much better off taking the money you would spend on metformin each month and instead donating it to Leafscience.org or The SENS RF. But I guess pills are appealing because you can buy them RIGHT NOW. n contrast to the findings from controlled trials, cases of lactic acidosis continue to be reported in patients taking metformin. Among the first million patients (approximately) to have received metformin in the U.S., there were 47 reports (20 fatal) to the FDA of lactic acidosis. Of these patients, 43 had renal failure (labeled contraindication for metformin) or risk factors for lactic acidosis besides metformin (primarily congestive heart failure) (16). There were only four patients who did not have other risk factors for lactic acidosis when metformin was initially given. In one of these four case subjects, lactic acidosis appears to have been precipitated by an episode of urosepsis. None of these four patients died. Taking the extended release version seems to eliminate side fx for m Continue reading >>
Eur J Endocrinol | Mobile
In two hospitalized obese, non-diabetic women on a 1250 calorie diet, the administration of metformin increased the rate of weight loss. A rebound effect was observed on withdrawal. These phenomena could not be correlated to changes in the total weight, dry weight or fat content of faeces or to variations in fluid intake and diuresis. Although faecal losses of fat and dry matter increased with the dose of metformin, the degree of malabsorption was too small to account for any significant part of the weight loss. The administration and the withdrawal of metformin produced changes in body weight similar to those provoked by restriction of calories, or selective carbohydrate restriction and re-alimentation, respectively. Since such rapid shifts in weight are largely due to changes in water-balance, it is highly probable that metformin reduces the amount of body water. The mechanism involved may concern a decrease in carbohydrate metabolism as well as an increase in that of fat. Continue reading >>
Syrosingopine Sensitizes Cancer Cells To Killing By Metformin
Syrosingopine sensitizes cancer cells to killing by metformin 1Biozentrum, University of Basel, 4056 Basel, Switzerland. 2Basilea Pharmaceutica International Ltd., Basel, Switzerland. 3Institute for Medical Microbiology, University of Basel, 4003 Basel, Switzerland. 4Molecular Pathology, University Hospital Basel, 4003 Basel, Switzerland. 5Stem Cell Center of Competence, University of Basel, 4056 Basel, Switzerland. *Corresponding author. Email: m.hall{at}unibas.ch We report that the anticancer activity of the widely used diabetic drug metformin is strongly potentiated by syrosingopine. Synthetic lethality elicited by combining the two drugs is synergistic and specific to transformed cells. This effect is unrelated to syrosingopines known role as an inhibitor of the vesicular monoamine transporters. Syrosingopine binds to the glycolytic enzyme -enolase in vitro, and the expression of the -enolase isoform correlates with nonresponsiveness to the drug combination. Syrosingopine sensitized cancer cells to metformin and its more potent derivative phenformin far below the individual toxic threshold of each compound. Thus, combining syrosingopine and codrugs is a promising therapeutic strategy for clinical application for the treatment of cancer. Metformin, an oral antidiabetic of the biguanide class, is the most widely prescribed drug for type 2 diabetes. It acts as a mild mitochondrial inhibitor, and its impact on key metabolic organs, such as the liver and muscle, results in reduced blood glucose levels and restoration of insulin responsiveness at the whole-body level. Metformin is a well-tolerated drug that can be taken for years with few adverse effects, such as rare cases of lactic acidosis. There is increasing evidence that metformin, in addition to its antidiabetic e Continue reading >>
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Sitagliptin 100mg Vs Glimepiride 13mg As An Add-on To Insulin And Metformin In Type 2 Diabetes (swim)
Sitagliptin 100 mg vs glimepiride 13 mg as an add-on to insulin and metformin in type 2 diabetes (SWIM) Jothydevs Diabetes Research Centre, Trivandrum, Kerala, India Correspondence should be addressed to J Kesavadev; Email: jothydev{at}gmail.com Objective To compare the effect of sitagliptin (100 mg) vs glimepiride (13 mg) as add-on therapy in Indian type 2 diabetes (T2DM) patients on treatment with insulin and metformin (SWIM study). Research design and methods This 24-week, controlled, open-label study randomized T2DM patients (n = 440) receiving a stable dose of metformin and insulin combination therapy to sitagliptin (100 mg) or glimepiride (13 mg) as add-on therapy. Baseline HbA1c was 7.3% and 8.5%. After a 6-week titration period for glimepiride (dose titrated every 2 weeks by 1 mg up to a maximum of 3 mg daily), patients were continued for 18 weeks on their respective tolerable doses of glimepiride (ranging from 1 mg to 3 mg) or sitagliptin (100 mg) along with metformin and insulin. Results Greater reductions in HbA1c and TDD of insulin were achieved with sitagliptin compared to glimepiride. HbA1c targets and reductions in TDD were achieved by more patients on sitagliptin than on glimepiride. Reductions in both body weight and BMI were also noted among patients on sitagliptin when compared to those on glimepiride, and more hypoglycemic events occurred with glimepiride treatment than with sitagliptin. Conclusions Sitagliptin (100 mg), when compared to glimepiride (13 mg), bestowed beneficial effects to T2DM patients in terms of achieving greater glycemic control and also brought significant reductions in total daily dose of insulin required, bodyweight, BMI and hypoglycemic events. Overall, the results suggest that sitagliptin (100 mg) is a superior agent over gl Continue reading >>
- Is It Time to Change the Type 2 Diabetes Treatment Paradigm? No! Metformin Should Remain the Foundation Therapy for Type 2 Diabetes
- Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes
- Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE)
Glyburide-metformin, Oral Tablet
Glyburide/metformin oral tablet is available only as a generic drug. It’s not available in a brand-name version. Glyburide/metformin only comes as a tablet you take by mouth. Glyburide/metformin is used to treat type 2 diabetes. This drug has a black box warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients about drug effects that may be dangerous. Glyburide/metformin can cause lactic acidosis. Don’t use this drug if you already have lactic acidosis. Lactic acidosis is a rare problem that happens when oxygen levels in your body drop. This leads to a buildup of lactic acid in your bloodstream. The condition can sometimes be fatal. Your risk of lactic acidosis may be higher if you have diabetes with kidney damage or heart failure. Other warnings Surgery or medical procedures warning: If you’re going to have surgery, magnetic resonance imaging (MRI), computerized tomography (CT) scan, or any other procedure, your doctor may temporarily stop your treatment with glyburide/metformin. Having procedures done that use radiocontrast dyes while taking this drug can cause kidney failure or lactic acidosis. Sun sensitivity warning Glyburide/metformin can make your skin more sensitive to the sun. This means you’re more likely to get sunburned. While you’re taking this drug, use sunscreen and wear protective clothing whenever you’re in the sun. Don’t use sun lamps or tanning beds or booths. Low blood sugar (hypoglycemia) warning: Glyburide/metformin can cause severe low blood sugar (hypoglycemia). This can cause seizures or fainting. It’s important to know how to spot and treat low blood sugar reactions as directed by your doctor. Symptoms may include: shakiness nervousness or anxiety swea Continue reading >>
Metformin Er Dosing : Pharmacy
Welcome to /r/Pharmacy , a subreddit for pharmacists, pharmacy students, techs, and anyone else in the pharmaceutical industry! If you have any suggestions or questions about this subreddit, don't hesitate to message the mods! User flair is enabled for all users to edit themselves! Just click the "(edit)" link above to type in manually. Some suggested flair: University and graduation date, work setting/title, or other professional titles. Do not ask for medical advice: We do not, and can not, provide official answers to your specific medical questions or provide professional judgment. Questions regarding specific medical advice will be removed. Our advice is to speak to your healthcare professional for answers specific to your condition. If you still want to trust a stranger on the internet, you can try /r/AskDocs . Do not ask questions regarding your prescription: For example, do not ask if/why you can/can't get your prescriptions filled early, or what to do if you were shorted on or lost/damaged your medication. If you have any questions regarding your specific prescription, refills or a shortage on your medication, this is not the place to ask. Contact your pharmacy instead. Posts that take a permissive view toward the illicit use, trafficking, or production of controlled substances will be deleted. Medical cannibis is included under this rule. This subreddit is for law-abiding pharmacy professionals. Users who are active in subreddits known to facilitate illicit drug use or trafficking are subject to being banned at the mods' discretion. Do not link, crosslink, or reference these subreddits in any way. Users asking how to acquire controlled substances illicitly or otherwise controvert the law will likewise be banned. Post pharmacy school related questions elsewhere Continue reading >>
Online Pharmacy Without Scripts Reddit
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Metformin - Steroids
site:www.reddit.com/r/steroids
Could A Diabetes Drug Help Beat Alzheimer's Disease?
Most of the 20 million people diagnosed with type 2 diabetes in the U.S. take metformin to help control their blood glucose. The drug is ultrasafe: millions of diabetics have taken it for decades with few side effects beyond gastrointestinal discomfort. And it is ultracheap: a month's supply costs $4 at Walmart. And now new studies hint that metformin might help protect the brain from developing diseases of aging, even in nondiabetics. Diabetes is a risk factor for neurodegenerative diseases, but using metformin is associated with a dramatic reduction in their incidence. In the most comprehensive study yet of metformin's cognitive effects, Qian Shi and her colleagues at Tulane University followed 6,000 diabetic veterans and showed that the longer a patient used metformin, the lower the individual's chances of developing Alzheimer's disease, Parkinson's disease, and other types of dementia and cognitive impairment. In line with some of the previous, smaller studies of long-term metformin use, patients in the new study who used the drug longer than four years had one quarter the rate of disease as compared with patients who used only insulin or insulin plus other antidiabetic drugs—bringing diabetics' risk level to that of the general population. The findings were presented in June at the American Diabetes Association's Scientific Sessions meeting. Even in the absence of diabetes, Alzheimer's patients often have decreased insulin sensitivity in the brain, says Suzanne Craft, a neuroscientist who studies insulin resistance in neurodegenerative disease at the Wake Forest School of Medicine. The association has led some people to call Alzheimer's “type 3 diabetes.” Insulin plays many roles in the brain—it is involved in memory formation, and it helps to keep synapses Continue reading >>
How Do You Dose Metformin As A Non Diabetic And When Do You Start Taking It?
How do you dose Metformin as a non diabetic and when do you start taking it? What are your thoughts? Log in or Sign up log in sign up At what age would you start? 20?30?40?50? I read that actually today but I have no clue what that calculation is based on. It's sourced yet, but no explanation has been given on why the "optimal" age of taking it is based upon the cost of Metformin. I dont care what is costs, I want to know if I can benefit from it from a health standpoint. And to find that out, we have to wait for the TAME study and not on some calculation based upon the daily cost of Metformin. Whatever that tells me. And even post-TAME, we won't really know about "optimal age" I wouldn't have thought. Being that it's taking place in 65-79 year olds. Who is your physician that was willing to prescribe? I'm 27... no physician, my friend brought me a couple packs from Spain (it's over the counter there) Supposedly GI Upset/diarrhea is a side effect which is why I chose to take it at night Back and neck pain. Supposedly it's until your body gets used to it, but damn, I had to stop. Might try starting back on a lower dose later. I wonder why it's those particular side-effects, as opposed to something else? Metformin is a direct SIRT1 activator and therefore should be taken in the morning if you want to go along with the circadian cycle That sounds good, happy to get on board with it. Do you have a source or reason as to why that should be the case? BTW, that's also true for NAD+ precursors.. Take them in the morning 500 mg 2X day for last 27 months. 58 yr old no adverse effects but better glucose numbers. Not diabetic. How did you get it if you aren't diabetic? Dr Alan Green in New York or just order it from India. Very inexpensive. Reasons to hope to see the age of 100 an Continue reading >>
Dr. Keith Roach: Is Metformin A Lifetime Medication?
Dr. Keith Roach: Is metformin a lifetime medication? DEAR DR. ROACH: I have been taking metformin 500 mg once daily for several months, with little results. I am in my 70s, and overweight by 25 pounds. My average sugar level is still around 160. I read that metformin will drop your glucose level by only 20 percent. Will that percentage increase if I take more? If so, by how much? Do I have to take metformin for the rest of my life? Will my body ever correct itself? - R.I. ANSWER: Average sugar level, also called estimated average glucose, is a way to describe blood sugar control in people with diabetes or prediabetes. A level of 160 is equivalent to an A1c level (a more commonly used measure of blood sugar control) of about 7.2 percent This is a reasonable level for most people in their 70s, where lower levels ("tighter" control) increase the risk for dangerously low blood sugars. Most medicines are more effective at higher doses. For metformin, 500 mg twice daily is the most common dose I see. Although it can be dosed up to 1,000 mg twice daily, it's not much more effective in most people, and is more likely to cause side effects, especially nausea. Not everybody with Type 2 diabetes needs to be on medicine forever. Losing weight, exercising regularly and having a prudent diet with small amounts of simple sugars all may help treat diabetes, and I have had many patients stop all their diabetes medications when adhering to these recommendations. Readers may email Dr. Roach questions to [email protected] or request an order form of available health newsletters at 628 Virginia Dr., Orlando, FL 32803. Digital access or digital and print delivery. Continue reading >>
Latest Antiaging Trend: Patients Experimenting With Prescription Drugs
Latest antiaging trend: Patients experimenting with prescription drugs by Marisa Taylor, Kaiser Health News, Updated:March 6, 2019 Studies have shown that rapamycin, a drug used in organ-rejection, helped mice with learning disorders, epilepsy, and autism learn as quickly as the healthy mice. Could it help people live longer? Alan Greens patients travel from around the country to his tiny medical practice in Queens, N.Y., lured by the prospect of longer lives. Over the past two years, more than 200 patients have flocked to see Green after learning that two drugs he prescribes could possibly stave off aging. One 95-year-old was so intent on keeping her appointment that she asked her son to drive her from Maryland after a snowstorm had closed the schools. Green is among a small but growing number of doctors who prescribe drugs off-label for their possible anti-aging effects. Metformin is typically prescribed for diabetes, and rapamycin prevents organ rejection after a transplant, but doctors can prescribe drugs off-label for other purposes in this case, for aging. Rapamycins anti-aging effects on animals and metformins on people with diabetes have encouraged Green and his patients to experiment with them as anti-aging remedies, even though theres little evidence healthy people could benefit. Many of [my patients] have Ph.D.s, said Green, who is 76 and has taken the drugs for three years. They have read the research and think its worth a try. In fact, its easier for patients to experiment with the drugs either legally off-label or illegally from a foreign supplier than it is for researchers to launch clinical trials that would demonstrate they work in humans. No rigorous large-scale clinical trials have been conducted aimed at aging. The FDA so far has not agreed that a t Continue reading >>
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Adjunctive Metformin For Insulin Resistance In T1d: A Clinical Perspective
Although generally well tolerated, metformin can increase the risk of gastrointestinal adverse effects. As a result of advances in treatment for type 1 diabetes (T1D) in recent decades, life expectancy of individuals with T1D has increased. However, along with the growing rates of overweight and obesity in both adolescents and adults with the disease, there has been an increase in insulin resistance, increased insulin dose requirements, and poor glycemic control in these patients.1 In addition, insulin resistance may have a greater role in the development of cardiovascular disease in [individuals with type 1 diabetes] than in affecting glycemic control, according to the authors of a review published in February 2018 in Diabetes Therapy.1 Studies have found that insulin resistance predicted coronary artery disease end points while HbA1c did not, and that it was a more significant predictor of the degree of coronary artery calcification than hyperglycemia.2,3 Adolescents with T1D and insulin resistance were shown to have reduced cardiopulmonary tness as well as diastolic dysfunction and left ventricular hypertrophy.4 These results further highlight the need to adequately address insulin resistance in individuals with T1D. To that end, researchers have been investigating the effects of metformin as an adjunct to insulin therapy in both adolescents and adults with T1D, with promising results reported thus far. Selected findings are highlighted below. In a 2008 meta-analysis of 5 prospective controlled trials involving adolescent and adult patients with T1D who either demonstrated insulin resistance (total daily insulin dose >0.9 U/kg) or who had a body mass index 25 kg/m2, a small but signicant reduction in HbA1c (-0.27%), a moderate reduction in insulin dose, and improvem Continue reading >>
Improved Glycemic Control With Minimal Systemic Metformin Exposure: Effects Of Metformin Delayed-release (metformin Dr) Targeting The Lower Bowel Over 16 Weeks In A Randomized Trial In Subjects With Type 2 Diabetes
Click through the PLOS taxonomy to find articles in your field. For more information about PLOS Subject Areas, click here . Improved glycemic control with minimal systemic metformin exposure: Effects of Metformin Delayed-Release (Metformin DR) targeting the lower bowel over 16 weeks in a randomized trial in subjects with type 2 diabetes Contributed equally to this work with: Robert R. Henry, Juan P. Frias, Brandon Walsh, Sharon Skare, John Hemming, Colleen Burns, Thomas A. Bicsak, Alain Baron, Mark Fineman Roles Conceptualization, Investigation, Methodology, Writing original draft, Writing review & editing Affiliation University of California, San Diego, La Jolla, CA, United States of America Contributed equally to this work with: Robert R. Henry, Juan P. Frias, Brandon Walsh, Sharon Skare, John Hemming, Colleen Burns, Thomas A. Bicsak, Alain Baron, Mark Fineman Roles Conceptualization, Investigation, Methodology, Writing original draft, Writing review & editing Affiliation National Research Institute, Los Angeles, CA, United States of America Contributed equally to this work with: Robert R. Henry, Juan P. Frias, Brandon Walsh, Sharon Skare, John Hemming, Colleen Burns, Thomas A. Bicsak, Alain Baron, Mark Fineman Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing original draft, Writing review & editing Contributed equally to this work with: Robert R. Henry, Juan P. Frias, Brandon Walsh, Sharon Skare, John Hemming, Colleen Burns, Thomas A. Bicsak, Alain Baron, Mark Fineman Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Resources, Supervision, Writing original draft, Writing review & editing Affiliation Elcelyx Therapeutics, Inc., San Diego, CA, United States of Amer Continue reading >>
- Association of Glycemic Variability in Type 1 Diabetes With Progression of Microvascular Outcomes in the Diabetes Control and Complications Trial
- The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus
- Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis
Who's Taking Metformin To Hopefully Slow The Aging Process?
Who's taking Metformin to hopefully slow the aging process? Also interested in the dosage. I'm personally around 75Kg and taking 1000mg a day. My Glucose levels (before Metformin) are just below pre-diabetic and 62 years old. New comments cannot be posted and votes cannot be cast Score hidden 7 months ago Stickied comment See also, recent discussion on whether there is any longevity benefit from metformin, or whether it is just beneficial for diabetics: Metformin Is a Direct SIRT1-Activating Compound Rather than randomly kneecapping your liver (PMC4074244), you'd be much better off if you addressed any metabolic syndrome directly. That is, lower your insulin resistance (which poorly controlled A1c is simply the end-state) by eliminating sugar/carb intake. If you are serious about longevity, I don't see any pharmaceutical treatments that impact all the various longevity metabolic pathways (PMC4531065) the way that IF and PF do, btw. Amen to that. IF + Keto adept here. Willing to PF anytime soon. 3 points 7 months ago edited 7 months ago 2 points 2 months ago edited 2 months ago I buy metformin often without a prescription here their prices are really cheap Since we have resorted to acronyms, I prefer MU and CQ and YX Intermittent Fasting, for example 16:8 (what I do), OMAD, 20:4... Thanks, I already do this but may consider limiting the carb intake a bit more. I do a CR diet right now. Do you think there's any advantage in IF and PF instead of Colorie Reduction? Actually yes! The topic of autophagy (micro, macro, mitophagy) is the hot new thing and there are effects that specifically seem to be related to prolonged fasting. Things like immune resets (PMC4102383) and cellular protection for cancer treatment (doi: 10.1038/onc.2011.91) , etc. For more reading I suggest PMC Continue reading >>
