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Metformin Dosage Reddit

Eur J Endocrinol | Mobile

Eur J Endocrinol | Mobile

In two hospitalized obese, non-diabetic women on a 1250 calorie diet, the administration of metformin increased the rate of weight loss. A rebound effect was observed on withdrawal. These phenomena could not be correlated to changes in the total weight, dry weight or fat content of faeces or to variations in fluid intake and diuresis. Although faecal losses of fat and dry matter increased with the dose of metformin, the degree of malabsorption was too small to account for any significant part of the weight loss. The administration and the withdrawal of metformin produced changes in body weight similar to those provoked by restriction of calories, or selective carbohydrate restriction and re-alimentation, respectively. Since such rapid shifts in weight are largely due to changes in water-balance, it is highly probable that metformin reduces the amount of body water. The mechanism involved may concern a decrease in carbohydrate metabolism as well as an increase in that of fat. Continue reading >>

Clomiphene Citrate Effect In Obese Men With Low Serum Testosterone Treated With Metformin Due To Dysmetabolic Disorders: A Randomized, Double-blind, Placebo-controlled Study

Clomiphene Citrate Effect In Obese Men With Low Serum Testosterone Treated With Metformin Due To Dysmetabolic Disorders: A Randomized, Double-blind, Placebo-controlled Study

Click through the PLOS taxonomy to find articles in your field. For more information about PLOS Subject Areas, click here . Clomiphene citrate effect in obese men with low serum testosterone treated with metformin due to dysmetabolic disorders: A randomized, double-blind, placebo-controlled study Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing original draft, Writing review & editing Affiliation Division of Endocrinology and Center for Applied Biomedical Research, Department of Medical & Surgical Sciences, Alma Mater Studiorum, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing original draft, Writing review & editing Affiliation Outpatients Clinic of Endocrinology and Metabolic Disease, Conversano Hospital, Bari, Italy Roles Data curation, Formal analysis, Investigation, Methodology, Resources Affiliation Division of Endocrinology and Center for Applied Biomedical Research, Department of Medical & Surgical Sciences, Alma Mater Studiorum, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy Affiliation Division of Endocrinology and Center for Applied Biomedical Research, Department of Medical & Surgical Sciences, Alma Mater Studiorum, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy Affiliation Division of Endocrinology and Center for Applied Biomedical Research, Department of Medical & Surgical Sciences, Alma Mater Studiorum, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy Affiliation Division of Endocrinology and Center for Applie Continue reading >>

Adderall Online Pharmacy Reddit

Adderall Online Pharmacy Reddit

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Metformin For Anti-aging - Explained, All Research And Overview

Metformin For Anti-aging - Explained, All Research And Overview

Metformin for Anti-Aging - Explained, All Research And Overview New comments cannot be posted and votes cannot be cast Original Poster12 points 7 months ago edited 7 months ago Urgent Update: Adding to AMPK signaling anti-aging research references + Metformin risk of protein synthesis slowdown. Thx to /u/vauss88 and /u/shrillthrill for help . Check back in 2 hours for better info on those areas. This 1-2 week thing is turning up to be pretty tough, sorry these are not as frequent as I would like, as I have to work on other things that pay the bills. It seems like every topic I want to cover comprehensively for you guys, is going to turn out to be a lot more HARDER than I imagined. It has been really challenging trying to get to the bottom of every one of these subjects. Biology is a bitch. Cliff: Ample evidence for scientists to form a indirect-hypothesis that Meformin at the very least makes people healthier than otherwise by acting AMPK, removing sugar from the bloodstream, triggering the benefits of sugar restriction. Direct human anti-aging evidence (clinical trials) is in progress and not complete. Metformin can be problematic for people with suboptimal kidney functions. It also depletes Vitamin B12 - so it Metformin can indeed backfire. I have now added a feedback comment system on the website (the speech bubble on the right), for any suggested changes or corrections please post it there. Everything else unrelated to correcting/changing the article, please keep it on r/longevity instead. The purpose of my blog is not to draw general discussion away from Reddit. I am thinking of working on baldness next, but due to the daunting nature of these topics, thinking it might be worth a shot to try a more collaborative approach? Stardust originally was designed by me to Continue reading >>

Could A Diabetes Drug Help Beat Alzheimer's Disease?

Could A Diabetes Drug Help Beat Alzheimer's Disease?

Most of the 20 million people diagnosed with type 2 diabetes in the U.S. take metformin to help control their blood glucose. The drug is ultrasafe: millions of diabetics have taken it for decades with few side effects beyond gastrointestinal discomfort. And it is ultracheap: a month's supply costs $4 at Walmart. And now new studies hint that metformin might help protect the brain from developing diseases of aging, even in nondiabetics. Diabetes is a risk factor for neurodegenerative diseases, but using metformin is associated with a dramatic reduction in their incidence. In the most comprehensive study yet of metformin's cognitive effects, Qian Shi and her colleagues at Tulane University followed 6,000 diabetic veterans and showed that the longer a patient used metformin, the lower the individual's chances of developing Alzheimer's disease, Parkinson's disease, and other types of dementia and cognitive impairment. In line with some of the previous, smaller studies of long-term metformin use, patients in the new study who used the drug longer than four years had one quarter the rate of disease as compared with patients who used only insulin or insulin plus other antidiabetic drugs—bringing diabetics' risk level to that of the general population. The findings were presented in June at the American Diabetes Association's Scientific Sessions meeting. Even in the absence of diabetes, Alzheimer's patients often have decreased insulin sensitivity in the brain, says Suzanne Craft, a neuroscientist who studies insulin resistance in neurodegenerative disease at the Wake Forest School of Medicine. The association has led some people to call Alzheimer's “type 3 diabetes.” Insulin plays many roles in the brain—it is involved in memory formation, and it helps to keep synapses Continue reading >>

Syrosingopine Sensitizes Cancer Cells To Killing By Metformin

Syrosingopine Sensitizes Cancer Cells To Killing By Metformin

Syrosingopine sensitizes cancer cells to killing by metformin 1Biozentrum, University of Basel, 4056 Basel, Switzerland. 2Basilea Pharmaceutica International Ltd., Basel, Switzerland. 3Institute for Medical Microbiology, University of Basel, 4003 Basel, Switzerland. 4Molecular Pathology, University Hospital Basel, 4003 Basel, Switzerland. 5Stem Cell Center of Competence, University of Basel, 4056 Basel, Switzerland. *Corresponding author. Email: m.hall{at}unibas.ch We report that the anticancer activity of the widely used diabetic drug metformin is strongly potentiated by syrosingopine. Synthetic lethality elicited by combining the two drugs is synergistic and specific to transformed cells. This effect is unrelated to syrosingopines known role as an inhibitor of the vesicular monoamine transporters. Syrosingopine binds to the glycolytic enzyme -enolase in vitro, and the expression of the -enolase isoform correlates with nonresponsiveness to the drug combination. Syrosingopine sensitized cancer cells to metformin and its more potent derivative phenformin far below the individual toxic threshold of each compound. Thus, combining syrosingopine and codrugs is a promising therapeutic strategy for clinical application for the treatment of cancer. Metformin, an oral antidiabetic of the biguanide class, is the most widely prescribed drug for type 2 diabetes. It acts as a mild mitochondrial inhibitor, and its impact on key metabolic organs, such as the liver and muscle, results in reduced blood glucose levels and restoration of insulin responsiveness at the whole-body level. Metformin is a well-tolerated drug that can be taken for years with few adverse effects, such as rare cases of lactic acidosis. There is increasing evidence that metformin, in addition to its antidiabetic e Continue reading >>

I Took Metformin For A Week And Here's What Happened

I Took Metformin For A Week And Here's What Happened

Craig Cooper Men's Health Leave a comment 0 I admit it: I took metformin for a week, the leading prescribed drug for treatment of type 2 diabetes ( 59.2 million units prescribed ) in the United States alone and taken by 80 million people around the world. This medication has been around for more than half a century and is often touted as a wonder drug for individuals with type 2 diabetes as well as for those living with other health challenges. My reasons for taking metformin were highly personal: I have a genetic predisposition for both prostate cancer and type 2 diabetes (Im not diabetic but I swing in and out of pre-diabetes based on my daily blood sugar readings), and Im getting older (who isnt!). I did copious amounts of research and it seemed on all three counts ( prostate cancer prevention , managing type 2 diabetes (increasing insulin sensitivity), and anti-aging), it truly was a wonder drug. Oh, and I had also read that pretty much every billionaire in Silicon Valley was on it mainly for its purported life extension benefits (as it can mimic the effect of calorie restriction see more below). Before I went on it I wanted to get some key blood indicators taken, specifically: Testosterone (total, free, and bioavailable). The plan was to have these indicators measured before taking metformin and then again, one month later. I really wasnt looking at metformin as a drug I was looking at it more as a superfood. Could it really have all these purported benefits with no real side effects? Why wouldnt I take it? After all, I dont take any other drugs so I had no real risk of the cocktail effect whereby it could have possibly interacted with other medications. However I quickly changed my mind for the reasons set out below, but I wanted to first share with you some of t Continue reading >>

Avoid The Metformin Bandwagon

Avoid The Metformin Bandwagon

From diabetes to cancer, berberine matches - or beats - this patent medicine every time! As many know, metformin is the number one prescription medication for type-2 diabetes. The patent for the name-brand of this patent medicine, Glucophage®, expired years ago and as a result generic-brand competition (metformin) brought this patent medicine’s price down so that it’s relatively inexpensive, especially when compared with nearly any other medication still covered by a patent. Mainstream medical research has found other uses for this un-natural molecule, including (but not limited to) lipid, blood pressure, and insulin resistance lowering effects, anti-cancer effects, improvement of polycystic ovarian syndrome, combatting Alzheimer’s disease, and extending life span in mice. Surprising guests on the metformin bandwagon Some proponents of natural therapies – including, surprisingly, two nationally and internationally circulated health magazines – have climbed on the metformin bandwagon, writing articles about the “health benefits” of metformin, and even advocating that otherwise healthy people take this patent medicine every day as a preventive. They admit that there are known side effects, but write that these are few, and that the benefits outweigh the risks. If there aren’t any natural treatment alternatives that are as effective, or more effective, than a patent medicine or other un-natural molecule – especially in serious or life-threatening situations – then the use of a patent medication of course makes sense. But when there are natural alternatives that work just as well or better, the rule is – and always should be – to “Copy Nature.” Human bodies are formed from the molecules of planet Earth, and powered by the energies of this planet Continue reading >>

Sitagliptin 100mg Vs Glimepiride 13mg As An Add-on To Insulin And Metformin In Type 2 Diabetes (swim)

Sitagliptin 100mg Vs Glimepiride 13mg As An Add-on To Insulin And Metformin In Type 2 Diabetes (swim)

Sitagliptin 100 mg vs glimepiride 13 mg as an add-on to insulin and metformin in type 2 diabetes (SWIM) Jothydevs Diabetes Research Centre, Trivandrum, Kerala, India Correspondence should be addressed to J Kesavadev; Email: jothydev{at}gmail.com Objective To compare the effect of sitagliptin (100 mg) vs glimepiride (13 mg) as add-on therapy in Indian type 2 diabetes (T2DM) patients on treatment with insulin and metformin (SWIM study). Research design and methods This 24-week, controlled, open-label study randomized T2DM patients (n = 440) receiving a stable dose of metformin and insulin combination therapy to sitagliptin (100 mg) or glimepiride (13 mg) as add-on therapy. Baseline HbA1c was 7.3% and 8.5%. After a 6-week titration period for glimepiride (dose titrated every 2 weeks by 1 mg up to a maximum of 3 mg daily), patients were continued for 18 weeks on their respective tolerable doses of glimepiride (ranging from 1 mg to 3 mg) or sitagliptin (100 mg) along with metformin and insulin. Results Greater reductions in HbA1c and TDD of insulin were achieved with sitagliptin compared to glimepiride. HbA1c targets and reductions in TDD were achieved by more patients on sitagliptin than on glimepiride. Reductions in both body weight and BMI were also noted among patients on sitagliptin when compared to those on glimepiride, and more hypoglycemic events occurred with glimepiride treatment than with sitagliptin. Conclusions Sitagliptin (100 mg), when compared to glimepiride (13 mg), bestowed beneficial effects to T2DM patients in terms of achieving greater glycemic control and also brought significant reductions in total daily dose of insulin required, bodyweight, BMI and hypoglycemic events. Overall, the results suggest that sitagliptin (100 mg) is a superior agent over gl Continue reading >>

10 Surprising Uses And Benefits Of Metformin, Including Side Effects/risks

10 Surprising Uses And Benefits Of Metformin, Including Side Effects/risks

Metformin is a prescription drug that successfully lowers blood sugar levels in type 2 diabetes patients. Metformin has many other (sometimes unknown) benefits, such as its use in cancer and polycystic ovarian syndrome (PCOS) treatment. However, metformin also has several adverse side effects and should be taken with precaution. Positive Effects of Metformin Currently, metformin is used not only as a first-line drug treatment for type 2 diabetes, but also for insulin resistance, PCOS, and even cancer. Metformin adjusts cellular energy consumption by targeting the liver, preventing it from creating more sugar, and inhibiting a hormone (glucagon) responsible for increasing blood sugar levels [R]. The effect of metformin on blood sugar levels can be attributed to AMPK, an enzyme that controls the production and storage of energy in cells by indicating that muscle cells should increase sugar absorption from the blood [R]. In a review of over 300,000 people, it was found that metformin may also reduce the risk of cancer in patients with type 2 diabetes through a known tumor suppressant (LKB1), which activates AMPK [R]. Recently, attention has shifted to non-AMPK mechanisms, often involving mitochondria, the parts of cells responsible for energy production [R]. Type 2 diabetes coexists with insulin resistance and patients develop extremely high blood sugar levels. Metformin lowers blood sugar, preventing permanent organ damage, which could eventually lead to dysfunction and failure [R, R]. Metformin exerts its effects through AMPK, which initiates the absorption of sugar from the blood into the muscles. It has been shown that metformin increases AMPK, which would imply pulling more sugar from the blood into the tissue and lowering blood sugar concentrations [R]. On the other Continue reading >>

Who's Taking Metformin To Hopefully Slow The Aging Process?

Who's Taking Metformin To Hopefully Slow The Aging Process?

Who's taking Metformin to hopefully slow the aging process? Also interested in the dosage. I'm personally around 75Kg and taking 1000mg a day. My Glucose levels (before Metformin) are just below pre-diabetic and 62 years old. New comments cannot be posted and votes cannot be cast Score hidden 7 months ago Stickied comment See also, recent discussion on whether there is any longevity benefit from metformin, or whether it is just beneficial for diabetics: Metformin Is a Direct SIRT1-Activating Compound Rather than randomly kneecapping your liver (PMC4074244), you'd be much better off if you addressed any metabolic syndrome directly. That is, lower your insulin resistance (which poorly controlled A1c is simply the end-state) by eliminating sugar/carb intake. If you are serious about longevity, I don't see any pharmaceutical treatments that impact all the various longevity metabolic pathways (PMC4531065) the way that IF and PF do, btw. Amen to that. IF + Keto adept here. Willing to PF anytime soon. 3 points 7 months ago edited 7 months ago 2 points 2 months ago edited 2 months ago I buy metformin often without a prescription here their prices are really cheap Since we have resorted to acronyms, I prefer MU and CQ and YX Intermittent Fasting, for example 16:8 (what I do), OMAD, 20:4... Thanks, I already do this but may consider limiting the carb intake a bit more. I do a CR diet right now. Do you think there's any advantage in IF and PF instead of Colorie Reduction? Actually yes! The topic of autophagy (micro, macro, mitophagy) is the hot new thing and there are effects that specifically seem to be related to prolonged fasting. Things like immune resets (PMC4102383) and cellular protection for cancer treatment (doi: 10.1038/onc.2011.91) , etc. For more reading I suggest PMC Continue reading >>

Update: Doctor Prescribed Me Metformin To Assist With Weight Loss. Thoughts/advice? - Diabetes

Update: Doctor Prescribed Me Metformin To Assist With Weight Loss. Thoughts/advice? - Diabetes

Update: Doctor prescribed me Metformin to assist with weight loss. Thoughts/advice? Link to original post: /r/diabetes/comments/6e8b1u/doctor_prescribed_me_metformin_to_assist_with/ Ok so, I decided to give it a go and I definitely regret the shit out of that decision. I was prescribed 1000mg 2x daily and I'm pretty sure that was way too much. I started it on Tuesday, and I felt okay. I was feeling a bit lethargic and headachy, but then yesterday, I started to experience intense stomach cramping, nausea, diarrhea and vomiting. I did a little research and learned that some of these symptoms are of the norm, but once I started puking, I freaked out. My doctor isn't in on Fridays, so I plan to call him on Monday to see what's going on, but until I speak to him, I'm going to hold off on taking the pills. Is this normal though? I was symptomatic of something called lactic acidosis which is a side effect of too high a metformin dosage. Since some of you are doctors, or may have experience with this sort of thing, what do you think happened and why? Continue reading >>

Metformin Er Dosing : Pharmacy

Metformin Er Dosing : Pharmacy

Welcome to /r/Pharmacy , a subreddit for pharmacists, pharmacy students, techs, and anyone else in the pharmaceutical industry! If you have any suggestions or questions about this subreddit, don't hesitate to message the mods! User flair is enabled for all users to edit themselves! Just click the "(edit)" link above to type in manually. Some suggested flair: University and graduation date, work setting/title, or other professional titles. Do not ask for medical advice: We do not, and can not, provide official answers to your specific medical questions or provide professional judgment. Questions regarding specific medical advice will be removed. Our advice is to speak to your healthcare professional for answers specific to your condition. If you still want to trust a stranger on the internet, you can try /r/AskDocs . Do not ask questions regarding your prescription: For example, do not ask if/why you can/can't get your prescriptions filled early, or what to do if you were shorted on or lost/damaged your medication. If you have any questions regarding your specific prescription, refills or a shortage on your medication, this is not the place to ask. Contact your pharmacy instead. Posts that take a permissive view toward the illicit use, trafficking, or production of controlled substances will be deleted. Medical cannibis is included under this rule. This subreddit is for law-abiding pharmacy professionals. Users who are active in subreddits known to facilitate illicit drug use or trafficking are subject to being banned at the mods' discretion. Do not link, crosslink, or reference these subreddits in any way. Users asking how to acquire controlled substances illicitly or otherwise controvert the law will likewise be banned. Post pharmacy school related questions elsewhere Continue reading >>

Metformin Weight Loss – Does It Work?

Metformin Weight Loss – Does It Work?

Metformin weight loss claims are something that are often talked about by health professionals to be one of the benefits of commencing metformin therapy, but are they true? At myheart.net we’ve helped millions of people through our articles and answers. Now our authors are keeping readers up to date with cutting edge heart disease information through twitter. Follow Dr Ahmed on Twitter @MustafaAhmedMD Metformin is possibly one of the most important treatments in Type II Diabetes, so the question of metformin weight loss is of the utmost importance, as if true it could provide a means to lose weight as well as control high sugar levels found in diabetes. What is Metformin? Metformin is an oral hypoglycemic medication – meaning it reduces levels of sugar, or more specifically glucose in the blood. It is so effective that the American Diabetes Association says that unless there is a strong reason not to, metformin should be commenced at the onset of Type II Diabetes. Metformin comes in tablet form and the dose is gradually increased until the maximum dose required is achieved. How Does Metformin Work & Why Would it Cause Weight Loss? Metformin works by three major mechanisms – each of which could explain the “metformin weight loss” claims. These are: Decrease sugar production by the liver – the liver can actually make sugars from other substances, but metformin inhibits an enzyme in the pathway resulting in less sugar being released into the blood. Increase in the amount of sugar utilization in the muscles and the liver – Given that the muscles are a major “sink” for excess sugar, by driving sugar into them metformin is able to reduce the amount of sugar in the blood. Preventing the breakdown of fats (lipolysis) – this in turn reduces the amount of fatt Continue reading >>

Online Pharmacy Without Scripts Reddit

Online Pharmacy Without Scripts Reddit

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