Side Effects Of Metformin: What You Should Know
Metformin is a prescription drug used to treat type 2 diabetes. It belongs to a class of medications called biguanides. People with type 2 diabetes have blood sugar (glucose) levels that rise higher than normal. Metformin doesn’t cure diabetes. Instead, it helps lower your blood sugar levels to a safe range. Metformin needs to be taken long-term. This may make you wonder what side effects it can cause. Metformin can cause mild and serious side effects, which are the same in men and women. Here’s what you need to know about these side effects and when you should call your doctor. Find out: Can metformin be used to treat type 1 diabetes? » Metformin causes some common side effects. These can occur when you first start taking metformin, but usually go away over time. Tell your doctor if any of these symptoms are severe or cause a problem for you. The more common side effects of metformin include: heartburn stomach pain nausea or vomiting bloating gas diarrhea constipation weight loss headache unpleasant metallic taste in mouth Lactic acidosis The most serious side effect metformin can cause is lactic acidosis. In fact, metformin has a boxed warning about this risk. A boxed warning is the most severe warning from the Food and Drug Administration (FDA). Lactic acidosis is a rare but serious problem that can occur due to a buildup of metformin in your body. It’s a medical emergency that must be treated right away in the hospital. See Precautions for factors that raise your risk of lactic acidosis. Call your doctor right away if you have any of the following symptoms of lactic acidosis. If you have trouble breathing, call 911 right away or go to the nearest emergency room. extreme tiredness weakness decreased appetite nausea vomiting trouble breathing dizziness lighthea Continue reading >>
Metformin - Oral, Glucophage
are allergic to dapagliflozin or any of the ingredients in FARXIGA. Symptoms of a serious allergic reaction may include skin rash, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. If you have any of these symptoms, stop taking FARXIGA and contact your healthcare provider or go to the nearest hospital emergency room right away have severe kidney problems or are on dialysis. Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with FARXIGA Dehydration (the loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at a higher risk of dehydration if you have low blood pressure; take medicines to lower your blood pressure, including water pills (diuretics); are 65 years of age or older; are on a low salt diet, or have kidney problems Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with FARXIGA. Ketoacidosis is a serious condition which may require hospitalization and may lead to death. Symptoms may include nausea, tiredness, vomiting, trouble breathing, and abdominal pain. If you get any of these symptoms, stop taking FARXIGA and call your healthcare provider right away. If possible, check for ketones in your urine or blood, even if your blood sugar is less than 250 mg/dL Kidney problems. Sudden kidney injury occurred in people taking FARXIGA. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or excessive heat exposure Serious urinary tract infections (UTI), some that lead to hospitalization, occu Continue reading >>
Polycystic Ovary Syndrome And Pregnancy: Is Metformin The Magic Bullet?
This article reviews the literature regarding the effects of metformin therapy in pregnant women with polycystic ovary syndrome on weight loss, fertility, early pregnancy loss, malformations, gestational diabetes mellitus, perinatal mortality, placental clearance, lactation, and early childhood development. The pharmacology of metformin is also presented. Preliminary data suggest that metformin for this population may be both safe and effective. Large blinded, randomized clinical trials are underway to confirm the preliminary safety data. History of Polycystic Ovary Syndrome Although the first description of polycystic ovary syndrome (PCOS) is generally credited to Stein and Leventhal in 1935, it may have been observed as early as 1721, when the Italian scientist Antonio Vallisneri observed “young married peasant women, moderately obese and infertile, with two larger than normal ovaries, bumpy and shiny, whitish, just like pigeon eggs.”1 This depiction sounds strikingly similar to the subfertility and obesity commonly found in PCOS. It was not until 1921 that Achard and Theirs2 noticed a relationship between hyperandrogenism and insulin resistance in their study of the “bearded diabetic woman.” And in 1935, Stein and Leventhal3 made the connection between amenorrhea and polycystic ovaries. In addition, they also noticed the occurrence of masculinizing changes, such as hirsutism and acne, in many patients with polycystic ovaries. Several, but not all, of Stein and Leventhal's original case studies involved women who were overweight. In all seven of their case reports, attempts to treat ovulatory dysfunction with estrogenic hormone failed, and wedge resection was employed. All of their patients gained normal menstruation, and two became pregnant. Surgery for PCOS Continue reading >>
Effect Of Metformin On Maternal And Fetal Outcomes In Obese Pregnant Women (empowar): A Randomised, Double-blind, Placebo-controlled Trial
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial Carolyn Chiswick , MBChB,a Rebecca M Reynolds , Prof, PhD,b Fiona Denison , MD,a Amanda J Drake , PhD,b Shareen Forbes , PhD,b David E Newby , Prof, DSc,c Brian R Walker , Prof, MD,b Siobhan Quenby , Prof, MD,d Susan Wray , Prof, PhD,e Andrew Weeks , Prof, MD,e Hany Lashen , MD,f Aryelly Rodriguez , MSc,g Gordon Murray , Prof, PhD,g Sonia Whyte , MSc,a and Jane E Norman , Prof, MDa,* aTommy's Centre for Maternal and Fetal Health, Medical Research Council (MRC) Centre for Reproductive Health, Queen's Medical Research Institute, Edinburgh, UK aTommy's Centre for Maternal and Fetal Health, Medical Research Council (MRC) Centre for Reproductive Health, Queen's Medical Research Institute, Edinburgh, UK aTommy's Centre for Maternal and Fetal Health, Medical Research Council (MRC) Centre for Reproductive Health, Queen's Medical Research Institute, Edinburgh, UK aTommy's Centre for Maternal and Fetal Health, Medical Research Council (MRC) Centre for Reproductive Health, Queen's Medical Research Institute, Edinburgh, UK aTommy's Centre for Maternal and Fetal Health, Medical Research Council (MRC) Centre for Reproductive Health, Queen's Medical Research Institute, Edinburgh, UK bBritish Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh, UK cChancellor's Building, Royal Infirmary of Edinburgh, Edinburgh, UK dDivision of Reproductive Health, Warwick Medical School, University of Warwick, Coventry, UK eFaculty of Health and Life Sciences, First Floor, Liverpool Women's Hospital, Liverpool, UK fAcademic Unit of Reproductive and Developmental Medicine, The Jessop Wing, Sheffield, UK gCentre for Popul Continue reading >>
- Glibenclamide and metfoRmin versus stAndard care in gEstational diabeteS (GRACES): a feasibility open label randomised trial
- Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE)
- The interpretation and effect of a low-carbohydrate diet in the management of type 2 diabetes: a systematic review and meta-analysis of randomised controlled trials
Stopping Metformin: When Is It Ok?
The most common medication worldwide for treating diabetes is metformin (Glumetza, Riomet, Glucophage, Fortamet). It can help control high blood sugar in people with type 2 diabetes. It’s available in tablet form or a clear liquid you take by mouth before meals. Metformin doesn’t treat the underlying cause of diabetes. It treats the symptoms of diabetes by lowering blood sugar. It also increases the use of glucose in peripheral muscles and the liver. Metformin also helps with other things in addition to improving blood sugar. These include: lowering lipids, resulting in a decrease in blood triglyceride levels decreasing “bad” cholesterol, or low-density lipoprotein (LDL) increasing “good” cholesterol, or high-density lipoprotein (HDL) If you’re taking metformin for the treatment of type 2 diabetes, it may be possible to stop. Instead, you may be able to manage your condition by making certain lifestyle changes, like losing weight and getting more exercise. Read on to learn more about metformin and whether or not it’s possible to stop taking it. However, before you stop taking metformin consult your doctor to ensure this is the right step to take in managing your diabetes. Before you start taking metformin, your doctor will want to discuss your medical history. You won’t be able to take this medication if you have a history of any of the following: alcohol abuse liver disease kidney issues certain heart problems If you are currently taking metformin, you may have encountered some side effects. If you’ve just started treatment with this drug, it’s important to know some of the side effects you may encounter. Most common side effects The most common side effects are digestive issues and may include: diarrhea vomiting nausea heartburn abdominal cramps Continue reading >>
Ttc With Pcos And Taking Metformin
I've had my implant out a month and haven't had my AF yet .. And no signs. I know it takes a while to sort itself out but I've been on metformin for about 3 weeks. I was put on 500mg for the first week and if I was ok go up 500mg and then a week later go up again until I was on 1500mg. It upset my tummy at first and I still get cramps from the 500mg so haven't up'd it yet, I'm worried if I do it will upset my tummy more so letting it settle into my body first. I was wondering if 500mg has helped anyone else before? I will up it next week if I need to but can't make my mind up, because the cramps are ok to deal with now but doubling might make it ten times worse so any advice is great. I didn't bleed on the implant, so now I have no idea what my body is doing, so stressful not knowing what is going to happen ... Just rather AF came now if it means getting back on track. I have never had regular AF and its always been very heavy when I was on implant. I am sorry to read you have experienced pain with the Metformim Metformin may cause side effects. Tell your doctor if any of these symptoms are severe, do not go away, go away and come back, or do not begin for some time after you begin taking metformin: Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency treatment: I would be inclined to have a chat with your GP before you up the dose Sorcha, as you say you don't want the pain to double This is exactly how I conceived my first, and the metformin made me sooooo ill, but it does subside if you can stick with it. You do not need to rush the upping of the dosage so quickly if it is too much, as you are putting a lot of pressure on your body and then trying to c Continue reading >>
Severe Bloating And Constipation In Early Pregnancy Digestive Metformin Problems
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Metformin Found Safe In Pregnant Women With Diabetes
Metformin Found Safe in Pregnant Women With Diabetes Adverse outcomes tied to diabetes, not the drug by Jeff Minerd Jeff Minerd, Contributing Writer, MedPage Today This article is a collaboration between MedPage Today and: Note that this observational study suggests that women who take metformin during pregnancy have no increased risk of adverse pregnancy outcomes, beyond those that arise through the presence of diabetes. Be aware that the authors did not analyze a group of women with diabetes but not treated with metformin. Pregnant women who took metformin for pregestational diabetes had a higher risk for adverse outcomes, but this risk was linked to the diabetes, not the drug, researchers reported. Pregnant women on metformin for other indications, such as polycystic ovary syndrome (PCOS), had no significantly increased risk for poor outcomes, Alice Panchaud, PhD, of the University of Geneva in Switzerland, and colleagues wrote online in the British Journal of Clinical Pharmacology . Compared with a matched reference group of pregnant women not taking metformin, metformin users with diabetes were nearly four times more likely to give birth to an infant with major birth defects (odds ratio 3.95; 95% CI 1.77 to 9.41). However, there was no significantly increased risk for pregnant women on metformin for other reasons (OR 0.83; 95% CI 0.18 to 2.81), the study found. Similarly, women taking metformin for pre-gestational diabetes had more than twice the risk for spontaneous abortion or stillbirth (OR 2.51; 95% CI 1.44 to 4.36), but women taking metformin for other indications had no significant risk increase (OR 1.38; 95% CI 0.74 to 2.59). The results were similar for other pregnancy outcomes the study examined, including the risk for pre-term birth and assisted delivery Continue reading >>
Constipation And Pregnancy
Unfortunately constipation can be a common problem during pregnancy and so how can you remedy this problem when you have gestational diabetes? Remedies to try that should not raise blood sugar levels Ensure you are drinking plenty Increase the amount of green leafy vegetables in your diet Add flaxseed into your diet - add it on top of Greek yoghurt One cup of hot water and lemon One cup of coffee in the mornings - filter coffee is great, but stay within your caffeine amounts for the day Raise your feet onto a stool when going to the toilet Laxatives - if natural remedies are not working then make an appointment with your GP to get a prescription for laxatives which are suitable for use during pregnancy. Commonly prescribed laxatives are Fybogel, Movicol and lastly Lactulose. Lactulose contains glucose but many mothers have used this with success and without it impacting their blood sugar levels Things to avoid - all these things will cause high blood sugar levels Prunes or prune juice Dried fruits; figs, apricots, dates, raisins e.t.c Fruit juices Weetabix, All bran e.t.c Molasses or sugared water Get Free Email Updates! Signup now and receive an email once I publish new content. I will never give away, trade or sell your email address. You can unsubscribe at any time. Continue reading >>
Metformin
Metformin may rarely cause a serious, life-threatening condition called lactic acidosis. Tell your doctor if you have kidney disease. Your doctor will probably tell you not to take metformin. Also, tell your doctor if you are over 65 years old and if you have ever had a heart attack; stroke; diabetic ketoacidosis (blood sugar that is high enough to cause severe symptoms and requires emergency medical treatment); a coma; or heart or liver disease. Taking certain other medications with metformin may increase the risk of lactic acidosis. Tell your doctor if you are taking acetazolamide (Diamox), dichlorphenamide (Keveyis), methazolamide, topiramate (Topamax, in Qsymia), or zonisamide (Zonegran). Tell your doctor if you have recently had any of the following conditions, or if you develop them during treatment: serious infection; severe diarrhea, vomiting, or fever; or if you drink much less fluid than usual for any reason. You may have to stop taking metformin until you recover. If you are having surgery, including dental surgery, or any major medical procedure, tell the doctor that you are taking metformin. Also, tell your doctor if you plan to have any x-ray procedure in which dye is injected, especially if you drink or have ever drunk large amounts of alcohol or have or have had liver disease or heart failure. You may need to stop taking metformin before the procedure and wait 48 hours to restart treatment. Your doctor will tell you exactly when you should stop taking metformin and when you should start taking it again. If you experience any of the following symptoms, stop taking metformin and call your doctor immediately: extreme tiredness, weakness, or discomfort; nausea; vomiting; stomach pain; decreased appetite; deep and rapid breathing or shortness of breath; dizzi Continue reading >>
Constipation And Diarrhea From Diabetes
Many people know diabetes can raise their odds of having heart disease and stroke. But it can affect your digestive tract, too. Digestion begins the minute you take a bite of food and ends a day or two later with a trip to the bathroom. The whole process is handled by the same part of your nervous system that controls other body functions that happen automatically, like your heartbeat and breathing. But over time, high blood sugar can damage the tiny blood vessels and nerves in your body, including your digestive system. A speed-up or slow-down of the process in your intestines could result in diarrhea or constipation. Diabetes medications, certain foods, and related illnesses can cause diarrhea, too. Nerve Damage About 60% to 70% of people with diabetes have some form of nerve damage, or diabetic neuropathy. It can develop at any time, but the longer you have diabetes, the more likely it is. When diabetes damages the nerves in your stomach and intestines, they may not be able to move food through normally. Most often, this causes constipation, but you can also get alternating bouts of constipation and diarrhea, especially at night. Misfiring nerves may not contract the muscles that mix and move the stuff in your intestines, so everything slows down. Your colon absorbs more moisture from the waste, which makes your poop harder -- and harder to pass. Constipation that lasts a long time can cause other health problems, such as fecal impaction, a hard lump of poop that blocks your rectum so nothing can get out. Fluid that lingers in your small intestine too long can allow too much bacteria to grow. This could lead to bloating, belly pain, and diarrhea. Nerve damage in your large intestine may let fluids move through too fast, or cause problems with absorbing and releasing Continue reading >>
Janumet Side Effects Center
Janumet (sitagliptin/metformin HCl) is a combination of oral diabetes medicines for people with type 2 diabetes who do not use daily insulin injections. Janumet is not for treating type 1 diabetes. Common side effects of Janumet include: nausea, vomiting, stomach upset, diarrhea, constipation, headache, weakness, back pain, joint or muscle pain, a metallic taste in the mouth, or cold symptoms such as runny or stuffy nose, sneezing, and sore throat. Janumet does not usually cause low blood sugar (hypoglycemia). Low blood sugar may occur if Janumet is prescribed with other anti-diabetic medications. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. Dosage of Janumet is individualized. Janumet is given twice daily with meals in 50 mg sitagliptin/500 mg metformin hydrochloride or 50 mg sitagliptin/1000 mg metformin hydrochloride doses. Hyperglycemia (high blood sugar) may result if you take Janumet with drugs that raise blood sugar, such as: isoniazid, diuretics (water pills), steroids, phenothiazines, thyroid medicine, birth control pills and other hormones, seizure medicines, and diet pills, or medicines to treat asthma, colds or allergies. Hypoglycemia (low blood sugar) may result if you take Janumet with drugs that lower blood sugar, such as: nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), beta-blockers, or probenecid. It may also interact with amiloride, triamterene, cimetidine, ranitidine, digoxin, furosemide, morphine, nifedipine, procainamide, quinidine, trimethoprim, or vancomycin. Tell your doctor all medications you use. During pregnancy, Janumet should be used only when prescribed. Your doctor may Continue reading >>
Metformin (oral Route)
Precautions Drug information provided by: Micromedex It is very important that your doctor check your progress at regular visits, especially during the first few weeks that you take this medicine. Blood and urine tests may be needed to check for unwanted effects. This medicine may interact with the dye used for an X-ray or CT scan. Your doctor should advise you to stop taking it before you have any medical exams or diagnostic tests that might cause less urine output than usual. You may be advised to start taking the medicine again 48 hours after the exams or tests if your kidney function is tested and found to be normal. Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests. It is very important to carefully follow any instructions from your health care team about: Alcohol—Drinking alcohol may cause severe low blood sugar. Discuss this with your health care team. Other medicines—Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems. Counseling—Other family members need to learn how to prevent side effects or help with side effects if they occur. Also, patients with diabetes may need special counseling about diabetes medicine dosing changes that might occur with lifestyle changes, such as changes in exercise or diet. Counseling on birth control and pregnancy may be needed because of the problems that can occur in pregnancy for patients with diabetes. Travel—Keep a recent prescription and your medical history with you. Be prepared for an emergency as you would norm Continue reading >>
What Is Metformin?
MORE Metformin is a prescription drug used primarily in the treatment of Type II diabetes. It can be used on its own or combined with other medications. In the United States, it is sold under the brand names Fortamet, Glucophage, Glumetza and Riomet. "Metformin is very often prescribed as the first step in a diabetic's regime," said Ken Sternfeld, a New York-based pharmacist. How it works "When you're diabetic you lose the ability to use the insulin you need to offset the food," Sternfeld explained. "If you eat a carb or sugar that can't be metabolized or offset by the insulin you produce, your sugar levels will be higher. Metformin and drugs in that category will help your body better metabolize that food so that insulin levels will be able to stay more in line." Metformin aims to decrease glucose production in the liver, consequently lowering the levels of glucose in the bloodstream. It also changes the way that your blood cells react to insulin. "It makes them more sensitive to insulin," said Dr. Stephen Neabore, a primary care doctor at the Barnard Medical Center in Washington, D.C. "It makes the same amount of insulin work better. It transports the insulin to the cells in a more effective way." Metformin may have a preventive health role, as well. New research presented at the American Diabetes Association 2017 Scientific Sessions showed that long-term use of metformin is particularly useful in preventing the onset of type II diabetes in women who have suffered from gestational diabetes. Because metformin changes the way the body uses insulin, it is not used to treat Type I diabetes, a condition in which the body does not produce insulin at all. Metformin & PCOS Metformin is sometimes prescribed to treat polycystic ovarian syndrome (PCOS), according to Neabore. "I Continue reading >>
Metformin Side Effects
Tweet Metformin does have several common side effects. Like almost all medication, Metformin will affect different people in different ways. The following lists details Metformin side effects, but this does not mean that all people taking Metformin will experience any or all of the following side effects. To make it easier to understand the frequency of the side effects of Metformin, we have divided them by how often they occur. Very common - affecting over 1 in 10 people taking Metformin Disturbance to the gut Nausea Vomiting Diarrhoea Abdominal pain Loss of appetite Common - affecting between 1 in 10 and 1 in 100 people taking Metformin Taste disturbance, usually a metallic taste Very rare - affecting under 1 in 10,000 people taking Metformin Elevated levels of lactic acid in the blood (lactic acidosis) Decreased absorption of vitamin B12 during long-term use Skin reactions such as rash, itching or flushing To find out more about Metformin side effects, people with diabetes should discuss the medication with their doctor and read the information provided by the manufacturer. The list of side effects above does not purport to be a full list of all recognised side effects of Metformin. What should I do if I experience Metformin side effects? All medicines take some getting used to. You should speak to your doctor if any of the side effects become troublesome or painful. If you find your breathing is being affected, along with drowsiness, dizziness and confusion you should stop taking Metformin at once and seek urgent medical attention. These are the symptoms of lactic acidosis, a rare but very serious condition that can be caused by Metformin. Tweet Type 2 diabetes mellitus is a metabolic disorder that results in hyperglycemia (high blood glucose levels) due to the body Continue reading >>
