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Metformin Causes Erectile Dysfunction

Resolving Erectile Dysfunction

Resolving Erectile Dysfunction

Dear David and Aisha, I am a 39-year-old married man who has had type 1 diabetes for 22 years. My A1C levels run around 7.5%. About six years ago, I started having trouble with erections. Now they are very rare, even with ED pills. I know you say that there is more to sex than intercourse, and my wife and I still enjoy ourselves however we can. But we both miss the erections. I have heard lately that erectile dysfunction can sometimes be improved. How can that happen? I don’t want any surgeries. What do you know about recovering erections? Happily Married but Frustrated Dear Happily Married, You picked a good time to write. Recent research has pointed to at least three ways that erectile dysfunction (ED) can be not only treated, but often resolved. Normalizing blood sugars can help; so can losing weight. There are also programs of “penis rehabilitation” that will improve erections. Glucose Levels First, what causes erectile dysfunction in diabetes? There are many causes, but the main one is nerve and blood vessel damage caused by high blood sugar. Elevated sugar levels contribute to inflammation, which can damage or kill nerves and narrow or block blood vessels, causing them to leak. Either factor can block erections. Fortunately, we now know that lowering blood sugar allows nerves, and sometimes blood vessels, to heal and regenerate. Just as neuropathic pain in the feet often resolves as blood sugars improve, nerve function to the genitals can too. Studies in the US, Egypt, and Italy consistently show that A1C levels are the strongest predictor of erection problems. The higher a person’s A1C, the more sexual problems he is likely to have. Your level of 7.5% is a bit high. If you could get closer to 6.5%, your sex life might improve significantly. Talk with your Continue reading >>

What Can Cause Erectile Dysfunction

What Can Cause Erectile Dysfunction

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Metformin Medication May Help Treat Erectile Dysfunction

Metformin Medication May Help Treat Erectile Dysfunction

New research suggests that the widely used type 2 diabetes drug metformin could double as a treatment for men with erection problems. In addition to helping people with type 2 diabetes keep control of their blood sugar levels, scientists at Georgia Health Sciences University in the US believe metformin may also provide an alternative option to anti-impotence drugs such as Viagra. Results from laboratory tests at the University, published online in the Journal of Sexual Medicine, showed the diabetes medication may improve erectile function by increasing levels of the naturally occurring chemical nitric oxide in the body. This makes blood vessels in the genital area more flexible and dilated, thus increasing the flow of blood into the penis. However, the tests were only conducted on laboratory rats so it is unclear whether the drug would have the same effect in humans. "Metformin is an old, cheap, well-tried and tested drug which is usually well tolerated," commented Dr David Edwards, a GP who runs the male sexual health clinic at the Oxfordshire-based White House Surgery. "But it was only used for 28 days, which is a short time, and just in rats. Many diabetics are already on metformin and yet erectile dysfunction is very common in this group. It may be that their problems might be worse if they were not on the drug." 10% of men in the UK experience erectile dysfunction at some point in their lives. Among people diagnosed with diabetes, it is even more common with up to 75% of diabetic men experiencing erection problems during their lifetime. Tweet Type 2 diabetes mellitus is a metabolic disorder that results in hyperglycemia (high blood glucose levels) due to the body: Being ineffective at using the insulin it has produced; also known as insulin resistance and/or Being Continue reading >>

How Diabetes Affects Sexual Function

How Diabetes Affects Sexual Function

Diabetes can affect sexual function, and as uncomfortable as it may sound, you may need to discuss this with your doctor (and certainly with your partner). To help you out, I have done research to bring you information about this most sensitive of subjects. First of all, having any chronic disease may in itself cause anxiety, which can result in sexual dysfunction. But having said that, it is also true that diabetics do report more sexual dysfunction than the populations at large. In his book Talking About Sex (American Psychiatric Press, Inc., 1995), Derek C. Polonsky, MD states that 20% of people with diabetes, both men and women, report sexual dysfunction. Please read the following with an open mind, not looking for something bad which will happen to you or a loved one. Rather use it as a tool to make you better informed, and more able to talk to the professionals in your life who can help when you need it. As Dr. Polonsky says, "What starts out as a physical problem is compounded by the emotional reaction to it." This article is shared to help all of us deal with the physical before this occurs. Research on Diabetes and Sexual Dysfunction There is more research on sexual dysfunction in males than females. In males, current research points to the need to develop a comprehensive biopsychosocial evaluation and treatment of diabetic patients with sexual dysfunction because of the high incidence of major depression and anxiety disorders noted in impotent men with neuropathy as compared to those who did not have depression, anxiety, or impotence, but had neuropathy. One caveat here is that just learning to cope with a chronic disease may cause psychiatric problems which may lead to lack of compliance, and may snowball into chronic complications, and so the process feeds o Continue reading >>

Type 2 Diabetes: Your Meds And Your Love Life

Type 2 Diabetes: Your Meds And Your Love Life

Dear Diabetes Health, I am 62 years old. I was diagnosed with type 2 diabetes in 1997, and I am doing OK on metformin. My last A1c was 7.2 %. About a year ago, they put me on medicine for my blood pressure (which was 142/90) and for cholesterol. I started having less interest in sex, which I had really liked before. About that time, I started to feel more down, so my nurse practitioner put me on an antidepressant. Now I have very little interest in sex. Even when my mind does, my body doesn’t, if you know what I mean. I suspect the medications may be causing my sexual problems. I’m thinking of throwing all my pills away. Jeanette Dear Jeanette, Diabetes, high blood pressure, and depression can all cripple sex drive and function. But your blood pressure and your sugars aren’t that high, and because of the timing, we agree that your medicines might be to blame for your loss of sex drive. The drugs used to treat hypertension, cholesterol, and depression have all been reported to damage sex life. When you are on four different medications, it’s hard to tell which pill is causing what. You will need to do some work with your doctor and/or pharmacist to find a medical regimen that gives you more benefits than side effects. Within all categories of meds, some are more likely to have sexual side effects than others. Perhaps you and your doctor can find some meds that work better, and stop some others. This article will give you some places to start. Your metformin is probably not part of the problem. It is very widely used, and there have been few reports of sexual problems. In fact, it often improves sexual function by bringing blood sugars down. Most blood sugar drugs don’t cause many sexual problems. Your other drugs are more problematic. Blood pressure drugs are n Continue reading >>

Over-supply Of Blood Sugar Could Be A Major Cause Of Erectile Dysfunction In Diabetic Men

Over-supply Of Blood Sugar Could Be A Major Cause Of Erectile Dysfunction In Diabetic Men

A new study from the Brady Urological Institute at Johns Hopkins suggests an over-supply of a simple blood sugar could be a major cause of erectile dysfunction in diabetic men. Researchers have found that one particular simple sugar, present in increased levels in diabetics, interferes with the chain of events needed to achieve and maintain erection and can lead to permanent penile impairment over time. The results, which have implications for new types of erectile dysfunction treatments targeting this mechanism of erection, are described in the August 16 issue of the Proceedings of the National Academy of Sciences. Previous research had shown that diabetic erectile dysfunction was partially due to an interruption in an enzyme that starts the chain of vascular events leading to an erection. The Hopkins team suspected O-GlcNAc, a blood sugar present in hyperglycemic (high blood sugar) circumstances, to be that interrupting factor. "We were interested to determine whether high glucose in diabetes mellitus modifies the endothelial nitric oxide synthase (eNOS) enzyme, which is responsible for the achievement and maintenance of erection," says Biljana Musicki, Ph.D., lead investigator of the study and a research associate in the Brady Urological Institute. Erectile dysfunction is a common problem for more than half of men with diabetes. Musicki says that an estimated "50 percent to 75 percent of diabetic men have erectile dysfunction to some degree, [a rate] about threefold higher than in non-diabetic men." This is not the same type of erectile dysfunction seen in non-diabetics, and it is less effectively treated with conventional drugs like Viagra. The study examined rats with type 1 diabetes mellitus as well as the overall mechanism of erection. "Erection begins when a sex Continue reading >>

Does Metformin Cause Erectile Dysfunction

Does Metformin Cause Erectile Dysfunction

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Do Statins Cause Erectile Dysfunction?

Do Statins Cause Erectile Dysfunction?

Q. The pain and trauma of erectile dysfunction in a loving relationship cannot be underestimated. I am a mature woman in a relationship with a man I adore who has ED. A blood pressure medication chemically castrated him first. When he stopped taking it, he was finally able to get intermittent erections, but the ED was still there, just not quite as bad. He was also on a high dose of simvastatin for cholesterol. He stopped taking it after I found out about its devastating effects on men. He’s been off it for several days and last night we both noticed a real difference! My advice for women in my situation is to try to keep the love and sexiness in your life. It may take much more time to turn your man on. Make sure there is no anxiety or stress over sexual performance and keep love and affection alive. A. The connection between statin therapy and erectile dysfunction has been controversial ever since Italian clinical researchers reported ED and lower testosterone in patients taking statins (Journal of Sexual Medicine, April 2010). Scientists have just confirmed in laboratory studies that statins inhibit testosterone production (Reproductive Toxicology, online Jan. 21, 2014). It seems that this might contribute to ED, especially in older men. Here are some other stories from men on statins: “I have been on Crestor for several years and mentally have sex drive, but can’t maintain an erection. I can understand not being able to have sex when I’m 95, but not at 65.” T.H. “I was on 20mg of atorvastatin for over a year. My sex drive was at an all time low and I did not have a full erection after taking it. I was also feeling tired. “My doctor, who put me on the 20mg, suggested I have my testosterone tested, which was below a normal level, but not much. He recomme Continue reading >>

Sexual Dysfunction - Causes And Symptoms

Sexual Dysfunction - Causes And Symptoms

Out-of-control blood sugar levels can lead to blood vessel and nerve damage that hamper sexual performance and enjoyment. This can cause diabetes-related sexual dysfunction in men as well as in women. Men and women with diabetes also should be aware of sexual function issues that affect both sexes. Other factors can cause or exacerbate sexual dysfunction, including psychological issues, self-consciousness and fear of failure. If you are experiencing impotence or sexual dysfunction, it's important to see your doctor for an accurate diagnosis of your condition. Diabetes can cause nerve and artery damage in the genital area, disrupting the blood flow necessary for an erection. This is more common in older men who have had diabetes for a long time. High cholesterol, high blood pressure and obesity - all common among men with diabetes - as well as smoking, can contribute to the problem. Some men with diabetes experience retrograde ejaculation, which means that the ejaculate goes backward into the bladder instead of being discharged during climax. This condition does not affect orgasm, but it can make it difficult to father a child. Diabetes-related nerve damage can cause vaginal dryness that makes intercourse uncomfortable. Nerve damage also can lead to loss of sensation in the genital area, making orgasm difficult or impossible to achieve. Urinary infections are more common in people with poorly controlled diabetes and can cause discomfort for women during intercourse and for men during urination and ejaculation. These generally are temporary complications, but they can recur. Sexual activity should be stopped during treatment of urinary tract and yeast infections, which also are relatively common in people with diabetes. Sexually transmitted diseases (STDs) can be transmit Continue reading >>

Male Erection Problems

Male Erection Problems

Let’s be honest: no man likes to talk about it. While it may not be a fun topic to discuss, male erection problems (or ED) is an issue that no man can afford to ignore. Occasional difficulty is one thing, but regularly struggling to get/maintain an erection is something that needs to be addressed. While you may think it’s just an inevitable part of getting older, most of the causes of ED are treatable…if you’re willing to put in some effort. So, rather than hoping that the problem goes away on its own (or worse, just letting your sex life fall apart), it’s time to educate yourself about your situation. Knowledge is power, right? With that in mind, here are 5 common causes of erectile dysfunction. Male Erection Problems & Low Sex Hormones When people think about ED, one of the first things that comes to mind is low testosterone. And while testosterone does have an impact on erections, they depend on a lot more than just your testosterone levels. In fact, some men with low-t don’t deal with ED at all. How is this possible? Well, the connection between testosterone and erections is a complicated one and scientists are still trying to figure out the correlation between the two. That being said, we know there are a few ways that low-t can cause erectile dysfunction, which are often driven by other conditions that men with low testosterone frequently have….like type 2 diabetes, obesity or metabolic syndrome… Metabolic Syndrome & Erectile Dysfunction Learn to beat ED without Drugs Free Ebook! An Erection Juice that Fires Up Morning Wood (page 23) The Number One Cause Of ED in Men Over 30 3 OTC Supplements That Harden Erections, Fast! Now, this one sounds intense, but it’s really just medical jargon for “a variety of conditions”. According to the Mayo Clin Continue reading >>

Erectile Dysfunction

Erectile Dysfunction

Erectile dysfunction means a man is unable to maintain an erect penis sufficient for satisfactory sexual intercourse. Many men have erection problems at times, and the likelihood increases with age. Erectile dysfunction may have a psychological or a physical cause, either way, it is distressing and may cause loss of confidence and self-esteem or depression, as well as relationship problems. There are several solutions, but recognising the problem and talking about it with your doctor are the first essential steps. What causes erectile dysfunction? How does an erection happen? The veins that allow blood to leave the penis are only so wide. During an erection, the blood vessels that let blood into the penis relax and widen (dilate). This lets more blood in – more than can escape – which causes the sponge-like tissues of the penis to swell and harden. Complex biological mechanisms are involved in allowing these blood vessels to relax and redirect blood to the penis. Your thoughts and senses (touch, hearing, smell and sight) influence a part of the brain that can trigger an erection. In addition, hormones and other substances determine how your nerves transmit ‘sexual signals’ and how blood vessels respond to the received signals. Arousing thoughts or nervous mechanisms (eg, touch reflexes) are two ways an erection is initiated. What causes an erection to fail? Erectile dysfunction occurs when sexual stimulation or arousal (you may still ‘have the urge’) does not result in sufficient blood flow to the penis. For most men there is a physical or medical reason for this, for others the problem is related to thoughts or emotions. Even when there is an initial physical reason, a man may still feel anxious about having sex, and this can compound the problem. Physical Continue reading >>

Metformin And Erectile Dysfunction

Metformin And Erectile Dysfunction

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Diabetes Pills Costing Just 2p Each Could Give Men's Love Lives A Lift

Diabetes Pills Costing Just 2p Each Could Give Men's Love Lives A Lift

Tablets costing just 2p each could be a new treatment for men with erection problems. New research suggests the medicine, called metformin, could boost a man's performance in the bedroom. The drug has been widely used on the NHS for many years to treat patients with type 2 diabetes. But now scientists think it may also work as an alternative to anti-impotence drugs such as Viagra or Cialis. Laboratory tests at the Georgia Health Sciences University in the U.S. show the diabetes drug boosts erectile function by relaxing blood vessels in the genital area, allowing blood to flow more freely into the penis. Although it has yet to be tested in humans, it could quickly emerge as a new treatment because it is readily available, extremely cheap and has an excellent safety record. One in ten men in the UK suffers erectile dysfunction at some point in their lives. Although drugs such as Viagra, Cialis and Levitra have revolutionised treatment in the last ten years, around 30 per cent of men who take them experience no improvement. For these men, the only other options are to inject drugs straight into the penis, or use a pump that manually increases blood supply to the organ. Neither is very popular. Metformin has been attracting a great deal of attention from researchers in recent years, mostly because it seems to hold promise as a potentially powerful new weapon against certain cancers, such as prostate, breast and ovarian tumours. The drug belongs to a class of medicines known as biguanides, which have been used for decades to treat type 2 diabetes - the form of the disease that normally affects obese people and those over 40. Taken twice a day, it works by reducing the amount of glucose produced by the liver and helping cells mop up sugar that is circulating in the bloodstrea Continue reading >>

Effects Of Metformin On Endothelial Health And Erectile Dysfunction

Effects Of Metformin On Endothelial Health And Erectile Dysfunction

Go to: Introduction Approximately 18 million American men are impacted by erectile dysfunction (ED) (1). ED may be attributed to several etiologies, including arteriogenic, psychogenic, neurogenic, hormonal, drug-induced, and systemic disease or aging related factors (2). Specific to arteriogenic ED, three major mechanisms have been identified: (I) Endothelium-dependent vasodilatory impairment, mediated by reduced bioavailability of nitric oxide (NO); (II) Sympathetic nerve activity elevation, resulting in enhanced basal and myogenic tone within the corpus cavernosum; (III) Atherosclerotic luminal narrowing, yielding reduced penile arterial inflow (3). Men with ED often share comorbid cardiovascular risk factors, such as obesity, dyslipidemia, diabetes, and hypertension, which in turn have common underlying pathophysiologic mechanisms including insulin resistance and inflammation, outlined in Figure 1 (4). Insulin resistance drives ED though complex mechanisms involving endothelial dysfunction, impaired vasodilatation, increased sympathetic tone, inflammation, and atherosclerosis (5-7). In this review we evaluate the hypothesis that metformin, an insulin sensitizer, modifies vascular physiology and thus impacts erectile function. First, we analyze the role of metformin in facilitating endothelium-dependent vasodilatation, regulating sympathetic nerve activity, and reducing hypertension, a major risk factor for atherosclerosis. Second, we review the current literature assessing the direct clinical relationship between metformin use and erectile function. Finally, we discuss the future potential use of metformin to address ED in the clinical setting. Continue reading >>

Ed + Dm = Cad

Ed + Dm = Cad

Endothelial dysfunction is the link between ED, DM and CAD. Diabetes is the second most common reason for erectile dysfunction, after vascular causes. According to the 2012 census, 15.5 million people suffered from erectile dysfunction, of which 50% was due to diabetes. Erectile dysfunction in diabetics occurs 10 to 15 years earlier than in men without diabetes. There are multiple factors that play into men with diabetes suffering from erectile dysfunction. Erectile dysfunction in diabetics can be determined by the age of the patient, duration of diabetes, degree of glycemic control, microvascular complications, and coexistence of cardiovascular diseases. In a healthy adult, there are three mechanisms that lead to a penile erection. They include: neurologically mediated cavernosal arterial flow, cavernosal smooth muscle relaxation, and restriction of venous outflow. Neuropathy is a common symptom suffered by many diabetes patients. Hence, the neurologically mediated cavernosal arterial flow is impeded due to neuropathy, which eventually leads to erectile dysfunction. In addition, insulin resistance in people with diabetes leads to endothelial dysfunction and atherosclerosis, which impairs vasodilation and reduces penile inflow and increases outflow. Nitric oxide, which is released by endothelial cells, causes a normal penile erection. Due to the endothelial dysfunction in people with diabetes, the release of nitric oxide is impaired in men with erectile dysfunction, hence resulting in vasoconstriction, smooth muscle cell proliferation, and further complicating arterial flow. A study conducted by Yamanaka M et al., concluded that erectile dysfunction was observed in diabetes patients with worse glycemic control. It also added that in animal studies, diabetes-associated e Continue reading >>

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