[full Text] Metformin: A Review Of Its Potential Indications | Dddt
Peer reviewers approved by Dr Salvatore Bongarzone Editor who approved publication: Dr James Janetka Yi-Wei Wang,1,* Si-Jia He,1,* Xiao Feng,1 Jin Cheng,1 Yun-Tao Luo,1 Ling Tian,2 Qian Huang1 1The Comprehensive Cancer Center and Shanghai Key Laboratory for Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Peoples Republic of China; 2Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Peoples Republic of China *These authors contributed equally to this work Abstract: Metformin is the most commonly prescribed drug for type 2 diabetes mellitus. In recent years, in addition to glucose lowering, several studies have presented evidence suggesting some potential role for metformin, such as antitumor effect, antiaging effect, cardiovascular protective effect, neuroprotective effect or an optional treatment for polycystic ovary syndrome. This paper will critically review the role of metformin to provide reference for doctors and researchers. Keywords: metformin, antitumor effect, antiaging effect, cardiovascular protective effect, neuroprotective effect, PCOS Metformin has become one of the most widely used drugs in the treatment of type 2 diabetes mellitus (T2DM) since its approval in the United Kingdom in 1958 and in the United States in 1995, with doses ranging from 500 to 2,500 mg/day. 1 It is the first-line therapy for patients with T2DM according to the American Diabetes Association/European Association for Study of Diabetes guidelines. 2 Metformin works by decreasing intestinal glucose absorption, improving peripheral glucose uptake, lowering fasting plasma insulin levels and increasing insulin sensitivity, which result in a reduction of bloo Continue reading >>
A Study Looking At The Drug Metformin In Breast Cancer
A study looking at the drug metformin in breast cancer A study looking at the drug metformin in breast cancer Please note - this trial is no longer recruiting patients. We hope to add results when they are available. drug metformin has on breast cancer , in women due to have chemotherapy before surgery . Cancers need food and oxygen to grow. But cancer cells seem to use these in different ways to healthy cells. Doctors call this cancer metabolism. This study is looking at a drug called metformin, which doctors use to treat diabetes. We know from research that metformin can kill cancer cells, almost certainly because of how it affects cancer metabolism. We also know that metformin seems to help chemotherapy to work better in people with breast cancer who take it for diabetes. But we do not yet know if this is the case for people with breast cancer without diabetes. Women taking part in this study will take metformin before, and possibly during, the chemotherapy they are having for their breast cancer. Researchers will look at scans, blood tests and biopsies from these women to gather information on how metformin affects cancer metabolism. They hope this study will help doctors predict which patients are most likely to respond well to this treatment in future. Have a condition where the chemical balance of your blood becomes too acid (metabolic acidosis) Have any other condition that would make you unwell if you took part, or affect the results of the trial you can check this with your doctor This phase 2 study will recruit 40 women. Everyone will take metformin every morning, for between 14 and 21 days. You increase the dose after 3 days, then again after 3 more days if you do not have any side effects. Everyone will also have a research PET-CT scan , breast biopsy and Continue reading >>
Breast Cancer Topic: Anyone Taking Metformin To Prevent Reoccurrance?
I am reading up on the topic. I asked my oncologist if she would prescribe it for me when I finished treatment and she declined. I plan on going back to my primary care doc and asking her. An oncology pharmacist friend told me the drug is very benign but oncologists won't start prescribing it until the results of a Phase III study are published. Anyone taking it to ward off reoccurance? Anyone struggling to get a prescription? Dx 11/9/2015, IDC, Left, 2cm, Stage IIA, Grade 3, 0/4 nodes, ER-/PR-, HER2- Chemotherapy 12/6/2015 Adriamycin (doxorubicin), Carboplatin (Paraplatin), Cytoxan (cyclophosphamide), Taxol (paclitaxel) Surgery 5/11/2016 Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement I take it for Triple Positive...I talked myprimary care docinto prescribing it for me and my Onc said fine. I believe I am in my third year now of taking it. I've had no side effects. Because of all the studies going on about it, I wanted to give it a shot! www.denise4health.info my BC Blog with over 200 informative posts - stop by and say hello! Myself, my mom, and sister were all diagnosed with BC within 3 years. What a ride! Dx 10/10/2011, IDC, Left, 6cm+, Stage IIIA, Grade 2, 9/14 nodes, ER+/PR+, HER2+ (FISH) Surgery 11/23/2011 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left Chemotherapy 12/27/2011 AC + T (Taxol) Targeted Therapy 2/28/2012 Herceptin (trastuzumab) Hormonal Therapy 10/11/2012 Arimidex (anastrozole) avmom Alberta Joined: Dec 2014 Posts: 304 Im taking the clinical trial dose (850 mg bid) on a prescription from my primary care physician, with the approval of my oncologist. I've been taking it for just over a year, with no significant side effects. I do have a history of PCOS, and th Continue reading >>
Metformin And Breast Cancer Stage At Diagnosis: A Population-based Study
Metformin and breast cancer stage at diagnosis: a population-based study Metformin and breast cancer stage at diagnosis: a population-based study I.C. Lega, MD MSc* , K. Fung, MSc*, P.C. Austin, PhD, L.L. Lipscombe, MD MSc*,, The objective of the present study was to use a large, population-based cohort to examine the association between metformin and breast cancer stage at diagnosis while accounting for mammography differences. We used data from Ontario administrative health databases to identify women 68 years of age or older with diabetes and invasive breast cancer diagnosed from 1 January 2007 to 31 December 2012. Adjusted logistic regression models were used to compare breast cancer stage at diagnosis (stages i and ii vs. iii and iv) between the women exposed and not exposed to metformin. We also examined the association between metformin use and estrogen receptor status, tumour size, and lymph node status in the subset of women for whom those data were available. We identified 3125 women with diabetes and breast cancer; 1519 (48.6%) had been exposed to metformin before their cancer diagnosis. Median age at breast cancer diagnosis was 76 years (interquartile range: 7282 years), and mean duration of diabetes was 8.8 5.9 years. In multivariable analyses, metformin exposure was not associated with an earlier stage of breast cancer (odds ratio: 0.98; 95% confidence interval: 0.81 to 1.19). In secondary analyses, metformin exposure was not associated with estrogen receptorpositive breast cancer, tumours larger than 2 cm, or positive lymph nodes. This population-based study did not show an association between metformin use and breast cancer stage or tumour characteristics at diagnosis. Our study considered older women with long-standing diabetes, and therefore further s Continue reading >>
Metformin, Anything New? - Her2 Support Group Forums
I'm seeing my onc on Thursday and wondered if there is anything new about taking Metformin for cancer patients - particularly HER2+,ER+ patients? I do still eat chocolate and take sugar in my coffee, I'm sadly addicted. Just wanted to say if chocolate improves your quality of life then I say eat a little chocolate! I second the chocolate in moderation for QoL. 11/12 BSE ignored the lump for SIX months. 5/20/13 IDC Stage IIb Grade 3 Nodes 1/4 also IDC and DCIS multi focal in remaining dissected tissue. 5/30/13 MUGA and CT thorax, abdomen & pelvis, establish baseline. 6/4/13 Installed my little purple power port. 6/14/13 Informed of suspicious ares on scans scheduled PET. 9/27/13 FINAL CHEMO taken! ----well, maybe not. 10/24/13 Radiation begins and fourth tattoo placed. 11/27/13 Perfectly radiant! Radiation completed the day before Thanksgiving and so, so much to be thankful for this year and every day hereafter. 1/2/14 Happy New Year, you have a Goiter? Muga down to 59%. 1/17/14 Hashimoto's Dz Dx'd. Now maybe I'll feel BETTER! 8/19/14 Prophylactic mastectomy (right) and PORT OUT! I'm DONE and now I really am a SURVIVOR. 2/15 Started not feeling so swell. Memory lapses and GI issues with nausea and blurry vision. 4/30/15 U/S cystic gallbladder, cyst on right ovary and mass in my uterus. GYN consult scheduled---and cancelled. I'm not ready. 5/4/15 Brain MRI clear (big sigh of relief) 8/31/15 Radiograph: compression fracture L2 10/1/15 CT guided biopsy & Brain to Pelvis MRI reveal additional lesions on spine C6, T10, T11 and L2 is collapsing. 10/8/15 Abbreviated pathology: new tumor(s) poorly differentiated carcinoma consistent with known breast primary. ER-/PR+ (40%) HER2/neu+++ Ki-67 4% Pancytokeratin AE1/3 Strong Positivity in all malignant cells. 10/13/15 Abnormal Dexa Continue reading >>
New To Forum, Metformin Question
I am a 60yr old female, type 2 for over 10 years. Been taking Metformin for 10+ years, taking 1000mg twice a day. Gone back and forth on diet and exercise, I do see my doctor regularly. Since a 9.4A1c end of August I decided to get serious about diet and exercise. Saw a dietician at the diabetes clinic late Sept, she liked what she saw as far as my diet (I write down what I eat and by blood sugar numbers, I test 3 times a day). My doctor sent me to the diabetes clinic after my 9.4A1c, they suggested I start Trulicity. After reading a lot of reviews I decided against it, so many people with explosive diarrhea, vomitting, etc. and no consistency as to when the side effects happened. This wouldn't work with my full time job. That's when I got serious! I've lost about 20lbs so far, my day time numbers took about a week to come down but they are much better now. I'm also using my exercise bike at least 5 times a week, 40 minutes. I currently take 1000mg Metformin with breakfast and 1000mg with dinner. My morning fasting blood sugar is still 170-190. My after work, before dinner # is usually 120-150's and my bedtime # in the 150's. I think the numbers should be lower based on what I'm eating, especially my morning numbers. The endocrinologist suggested trying 3 Metformin at dinner and one in the morning. I only tried it for a couple weeks, the first few days my morn #'s were lower, then went back up and my day numbers were higher. So I went back to 2/2. What about taking the Metformin at bedtime, has anyone tried that? I've never had any side effects to Metformin and I don't have any other diabetic issues, or health issues. I am a 11yr breast cancer survivor!! I also realize I may be being impatient and it may take awhile of the diet/exercise before my #'s really come down l Continue reading >>
Does Anyone Take Metformin?
3 years 6 months ago - 3 years 6 months ago #48685 by sweetheart238 Dear yoksgrl, i'm too but after 4 months taking Metformin bladder tumor was developed . Agree with you that cancer is the emperor of all maladies Please Log in or Create an account to join the conversation. 3 years 6 months ago #48666 by rocksteady This just may be a coincidence but I had symptom of burning upon urination. I saw my doctor and a urologist.I felt it was caused by something in my diet or meds. I also happened to have started metformin approx 6 months earlier. Before my cystoscope, I stopped metformin because of stomach/ digestive problems. Of course, the burning stopped almost immediately. I told the urologist about it and he just said 'that's good'. The burning came back when I had BCG,so much that I could barely hold it in for 15 minutes but eventually stopped after about the 4th installation. They still haven't told what caused the burning...enlarged prostate, CIS or something else ( like metformin). So I don't know if the metformin played a role, but seeing all these complaints and questions really makes me wonder. btw, it really lowered my A1C Please Log in or Create an account to join the conversation. I have been taking metformin for more than 12 years now and January of 2014 I was diagnosed with bladder cancer (5 tumors) after passing blood in urine along with frequent and painful urination for quite some time prior to being diagnosed. I went through 6 treatments of BCG and was clear of cancer for 9 months. Now at 12 months, 2 tumors have recurred that were more aggressive than the previous ones. I recently had the two removed surgically. I am convinced that, after extensive research on the Web, there's a link between metformin and bladder cancer. Recently, there has been a lawsui Continue reading >>
Bladder Cancer And Metformin
Sara Anne, Thank you for replying to my post. I had been reading online that there could be some connection between longterm use of metformin and bladder cancer. I have never smoked and there is no history of this type of cancer in my family. I have stopped taking metformin as my ovaries were removed and never been diagnosed with diabetes. I'm very grateful that I was able to have two children via ivf before getting endometriosis resulting in the hysterectomy. Now, once I have healed, I will start treatment for the bladder cancer. Thank you again for replying to my post. Please Log in or Create an account to join the conversation. 3 years 7 months ago - 3 years 7 months ago #48563 by Mom of 2 Bladder cancer and metformin. I was just diagnosed on March 10th with non invasive bladder cancer. For over five years was taking metformin to treat Poly Cystic Ovaries. On March 3rd I had a complete hysterectomy, removing the ovaries,fallopian tubes,uterus,and cervix. I also had a bladder biopsy done due to inflammation not caused by infection. Has anyone ever been diagnosed with bladder cancer caused by the use of metformin? I can't start treatment for the bladder cancer until I have healed from the hysterectomy. Any advice would be greatly appreciated as I am newly diagnosed. Thank you. Last edit: 3 years 7 months ago by Mom of 2. Continue reading >>
Metformin May Improve Outcomes In Patients With Prostate Cancer
Metformin may improve outcomes in patients with prostate cancer Member visible suburb, city, state or territory:Wichita, Kansas USA LocationWichita, Kansas USA (south-central Kansas on a map of the U.S. Metformin (Brand names Fortamet, Glucophage, Glucophage XR, Glumetza, Riomet) was originally prescribed to be used alone or with other medications, including insulin, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Metformin is in a class of drugs called biguanides. Metformin helps to control the amount of glucose (sugar) in your blood. It decreases the amount of glucose you absorb from your food and the amount of glucose made by your liver. Metformin also increases your body's response to insulin, a natural substance that controls the amount of glucose in the blood. Metformin is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood). Metformin is the new kid on the block or med on the block for prostate cancer and only recently being more prescribed, and since sugar, by way of insulin, can be a contributor to cancer cell growth, it can be reasonably recognized why this product can rein in that growth. Even though sugar doesnt exactly feed cancer cells, it is a good idea to limit the amount of simple sugar you eat. This is because when you eat a lot of sugar, your body produces a lot of insulin. Insulin is a natural substance made by the body. Insulin can tell cells to grow. In simple terms, insulincan rev up cell growth. For healthy cells,this is a good thing. This is because thecells in your body grow, divide, die, and are replaced as part of the natural process of living. Continue reading >>
Metformin In Cancer Prevention And Therapy
Metformin in cancer prevention and therapy Department of Internal Diseases, Diabetology and Clinical Pharmacology, Medical University of Lodz, ul. Pomorska 251, 92-213 Lodz, Poland Correspondence to: Jacek Kasznicki. Department of Internal Diseases, Diabetology and Clinical Pharmacology, Medical University of Lodz, ul. Pomorska 251, 92-213 Lodz, Poland. Email: [email protected] . Received 2014 Mar 15; Accepted 2014 May 23. Copyright 2014 Annals of Translational Medicine. All rights reserved. This article has been cited by other articles in PMC. The prevalence of diabetes is dramatically increasing worldwide. The results of numerous epidemiological studies indicate that diabetic population is not only at increased risk of cardiovascular complications, but also at substantially higher risk of many forms of malignancies. The use of metformin, the most commonly prescribed drug for type 2 diabetes, was repeatedly associated with the decreased risk of the occurrence of various types of cancers, especially of pancreas and colon and hepatocellular carcinoma. This observation was also confirmed by the results of numerous meta-analyses. There are however, several unanswered questions regarding the exact mechanism of the anticancer effect of metformin as well as its activity against various types of cancer both in diabetic and nondiabetic populations. In the present work we discuss the proposed mechanism(s) of anticancer effect of metformin and preclinical and clinical data suggesting its anticancer effect in different populations. Keywords: Metformin, cancer, molecular action, clinical evidence The prevalence of diabetes is dramatically increasing worldwide reaching epidemic proportion. Landmark of diabetes, chronic hyperglycemia leads to the development and progressi Continue reading >>
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Building The Clinical Evidence On Metformin And Cancer
Population studies, mouse models, and mechanistic studies all show that metformin, a cheap well-tolerated diabetes drug, impacts in some way on how some cancers develop and progress. Anna Wagstaff talks to clinicians and researchers building the evidence on what it can deliver in the clinic. In the early 2000s diabetologists began reporting an unusually low rate of cancer among their patients who were treated with What happened next seemed to follow a false-dawn pattern that has become all too familiar in the history of cancer research. A series of epidemiological studies came out showing large effect sizes, some showing cancer rates more than halved in metformin users results that wiser heads cautioned were simply too good to be true. But then attempts to back up the findings with lab studies confounded the sceptics: whether used against cancer cells in petri dishes or against tumours in mice models, metformin did indeed inhibit cancer growth. That was the golden period, says Michael Pollak, whose lab at the McGill translational research centre in Montreal, Quebec, was one of those tasked with carrying out the research. It appeared that we had independent evidence from population studies and lab studies that projected that metformin had a bright future in treating cancer, at least in diabetics and even in patients without diabetes. As the excitement rose, so did the number of studies. But then uncertainty began to creep in. Research done to confirm the early epidemiological reports found no evidence, or conflicting evidence, of a protective effect. And while the findings of the lab studies were found to be robust, questions emerged about dosing levels: was the anticancer activity occurring at drug levels higher than those that are or ever could be achieved in humans? Continue reading >>
Will Metformin Become The First Anti-aging Drug?
Will Metformin Become the First Anti-Aging Drug? A committed group of scientists is seeking to validate metformin as the first-ever anti-aging medication.1,2 In this day of staggering drug prices, metformin is available as a low-cost generic. One mechanism by which metformin works is by activating AMPK, an enzyme inside cells that lowers blood sugar by promoting energy utilization. Activating AMPK has broad-ranging effects that extend far beyond blood sugar control. Studies show that boosting AMPK activity can preventand even reversethe life-shortening effects of aging, such as cardiovascular disease, diabetes, neurodegenerative diseases, cancer, and more.3 In this article, well review data that persuaded the FDA to allow metformin to be studied in humans as the first anti-aging drug.1 The most commonly prescribed antidiabetic drug is metformin. It has been in use in England since 1958 and in the United States since 1995. Derived from a compound found in the French Lilac, metformin has a track record of safety and effectiveness at routine doses of up to 2,000 mg daily.4-7 So what evidence is there for the FDA to consider this drug as an anti-aging medication? The reason is simple: Metformin can block or diminish many of the fundamental factors that accelerate aging.8-12 These include protecting against DNA damage glycation, poor mitochondrial function, and chronic inflammation. Metformin has been shown to facilitate DNA repair, which is critical for cancer prevention. By attacking these fundamental degenerative processes, metformin can prevent the development of agings most troubling diseases. Metformin has also been shown to increase the production of known longevity-promoting signaling molecules in cells, such as mTOR and AMPKall of which reduce fat and sugar storage Continue reading >>
Breast Cancer Survival Boosted By Metformin, Study Finds
Has Anyone Tried Metformin To Increase Ampk Activation?
@JaimeS just posted some summaries of CFS studies and this one caught my eye... Metformin increases AMPK activation, so I'm wondering why Metformin isn't rx'ed for CFS patients... Has anyone tried this drug? Did it help w energy levels? thanks. Julie Newton and her team discovered that muscle cells of patients with ME had increased myogenin expression but decreased IL-6 secretion in comparison to controls and, when an electrical pulse was sent through the tissue to simulate exercise, muscle cells of ME patients demonstrated impaired AMPK activation and impaired uptake of glucose. Cells responded normally to insulin. I'm type 2 diabetic so I was on metformin for a few years, before I suddenly became extremely intolerant of them. I can't say i noticed any particular benefit to them, for either M.E. or diabetes. @JaimeS just posted some summaries of CFS studies and this one caught my eye... Metformin increases AMPK activation, so I'm wondering why Metformin isn't rx'ed for CFS patients... Has anyone tried this drug? Did it help w energy levels? thanks. Julie Newton and her team discovered that muscle cells of patients with ME had increased myogenin expression but decreased IL-6 secretion in comparison to controls and, when an electrical pulse was sent through the tissue to simulate exercise, muscle cells of ME patients demonstrated impaired AMPK activation and impaired uptake of glucose. Cells responded normally to insulin. At one point, I did a bit of PR-research on metformin. I don't recall whether or not any of these were in private threads, so I'm anonymizing them. 2 patients with CFS and diabetes (Type II) do well on it! One patient did fine with it for pre-diabetes, but stopped when contracted CFS; when tried to start it up again, adverse fx resulted. I tried metfor Continue reading >>
Metformin - Prostate Cancer Forum - Cancer Forums
If this is your first visit, be sure to check out the FAQ by clicking the link above. You may have to register before you can post: click the register link above to proceed. To start viewing messages, select the forum that you want to visit from the selection below. Have any of you participated in a trial using Metformin in lieu of adjuvant radiation? Apparently this drug has some very good results and interferes with insulin receptors in cells. It has been recommended to me. Steve December 16 Final Pathology Report Johns Hopkins Summed length of positive margin 3mm - highest grade at point of margin 4+4=8 Area directly adjacent to harvested core comes within <0.1cm of the nearest inked black capsule December 9 - Johns Hopkins Robotic RP - Dr. Mohammad Allaf October - Johns Hopkins upgrades 4+4 to 4+5+9 September Biopsy 5/13 positive; Gleason 4+3, 3+4, 4+3, 4+3, 4+4. 2011 PSA 1.9; 2013 PSA 3.7, 8/2014 PSA 3.3, 9/2014 PSA 2.9 - Biopsy 1!/2014 - Results 3/12 cores positive; all 3 cores Gleason 3+3, (right apex lateral <5%, left apex medial 25%, left mid lateral 10% I haven't been tracking that particular product; though DO KNOW it's used to treat diabetes. I would personally look at the Mayo Website to check for side effects of the product. For some reason I was thinking there are (long term) side effects from Metformin. (I believe there's a class action suit on ONE of the diabetes treatments). GOOD LUCK to you! Post Op: Gleason - 9 with Metastatic Disease (lymph node involvement) 38 Salvage Radiation Treatments completed 11/12/15 6 Chemotherapy Treatments completed 09/23/2016 Hormone treatments: 4th Eligard Treatment 12/29/2016 Oncologist visit February 22, 2016 Told there is an 80% chance the cancer will return (no cure, moved to containment mode) I recently read an ar Continue reading >>