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Invokamet, Invokana Lawsuit Investigation: Diabetes Amputation, Diabetic Ketoacidosis

Invokamet, Invokana Lawsuit Investigation: Diabetes Amputation, Diabetic Ketoacidosis

Were you or a loved one injured by Invokana side effects or Invokamet side effects? The U.S. Food and Drug Administration has warned that taking certain type-2 diabetes medications may increase patients’ risk of lower limb amputation and diabetic ketoacidosis. These diabetes side effects are associated with a class of drugs called sodium-glucose cotransporter-2 (SGLT2) inhibitors. SGLT2 inhibitor diabetes medications include: Invokana (canagliflozin) Invokamet (canagliflozin metformin) Invokamet XR (canagliflozin and metformin hydrochloride extended-release) If you or a loved one were diagnosed with diabetic ketoacidosis and/or had to undergo diabetic amputation of the toe, foot, knee or leg after taking one of the diabetes drugs listed above, you may have a legal claim. Fill out the form on this page now for a FREE case evaluation. The FDA has confirmed an increased risk of leg and foot amputations with the diabetes medicine canagliflozin, sold under the brand names Invokana, Invokamet, Invokamet XR. Studies show that people taking these medications are twice as likely to undergo lower limb amputation compared to patients taking a placebo, including diabetic amputation of the toe, foot, knee or leg. Diabetic amputations of the toe and middle of the foot were the most common; however, diabetic amputations involving the leg, both below and above the knee, also occurred. Some patients had more than one lower limb amputation, some involving both limbs, according to the FDA. The risk for Invokana amputation and Invokamet amputation may be higher for some people, including those who have peripheral vascular disease, neuropathy (nerve damage), or diabetic foot ulcers (sores), or who have a history of prior diabetes amputation. In a May 16, 2017 safety announcement, the FDA Continue reading >>

Diabetes Medication Lawsuits

Diabetes Medication Lawsuits

A number of diabetes drugs have been linked in studies and lawsuits to serious drug side effects, including acute pancreatitis and pancreatic cancer. Some class action diabetes lawsuits have resulted in settlements with the plaintiffs. Other lawsuits are just getting underway. Whereas type 1 diabetics need to inject insulin several times a day to stay alive, type 2 diabetics are treated with a variety of glucose-lowering drugs, and combinations thereof. Type 2 diabetes occurs when the pancreas doesn't produce enough insulin to maintain a normal blood glucose level, or the body is unable to use the insulin that is produced. Diabetes, a lifelong condition, causes a person's blood sugar level to become too high. Four main risk factors for developing type 2 diabetes are genetics, age, weight and ethnicity. Almost 26 million Americans have diabetes, and up to 95 percent of these cases are type 2 diabetes. There are several classes of diabetes drugs that work in different ways to lower blood sugar (glucose). Sulfonylureas have been used to treat diabetes since the 1950s while the first drug in a new class of medications called DPP-4 inhibitors was approved by the FDA in 2006. Sitagliptin was the first DPP-4 Inhibitors approved, followed by a combined product of sitagliptin and glucophage and saxagliptin in 2007. A group of dugs known as incretin mimetics includes Byetta, Bydureon, Victoza, Januvia and other medications. Sulfonylureas Biguanides Meglitinides Thiazolidinediones DPP-4 inhibitors (gliptins, or dipeptidyl peptidase-4) SGLT2 Inhibitors (sodium-glucose cotransporter-2 ) Alpha-glucosidase inhibitors Bile Acid Sequestrant For more information visit the American Diabetes Association. Actos (exenatide) Associated risks: bladder cancer, heart failure. Avandia (rosiglitaz Continue reading >>

Glucophage / Metformin

Glucophage / Metformin

Glucophage, also known as metformin, is indicated for the treatment of type II diabetes, a serious disorder of blood sugar control. In people with diabetes, the pancreas does not produce enough insulin to control blood sugar, which then rises to harmful levels. Glucophage lowers these blood sugar levels by increasing the body's response to its own insulin. The drug decreases the amount of sugar the liver makes and the amount of sugar the intestines absorb. The U.S. Food and Drug Administration approved Glucophage, made by Bristol-Myers Squibb Company, in 1994. Common side effects of Glucophage use include, but may not be limited to, a metallic taste in the mouth, diarrhea, nausea and upset stomach. Glucophage should not be used by patients with kidney disease or by those taking medications for heart failure . A boxed warning indicates that Glucophage may cause lactic acidosis (buildup of lactic acid in the blood), which is serious and can be fatal. This occurs mainly in people whose kidneys are not functioning properly. Patients given Glucophage should be made aware of lactic acidosis symptoms -- malaise, rapid breathing, shortness of breath and severe weakness. Lactic acidosis can be diagnosed with laboratory tests and requires that Glucophage therapy be stopped immediately and proper supportive care initiated. A report published in the May 2002 issue of the Journal of the American Medical Association revealed that doctors prescribe a significant number of patients Glucophage even though the patients suffer from heart and kidney disorders. The study, which involved 100 patient prescriptions from a University of North Carolina hospital pharmacy, found that one-fourth of the users were inappropriately prescribed Glucophage. Researchers involved in the study fear doctors Continue reading >>

Metformin Side Effects

Metformin Side Effects

shakiness dizziness or lightheadedness sweating nervousness or irritability sudden changes in behavior or mood headache numbness or tingling around the mouth weakness pale skin hunger clumsy or jerky movements If hypoglycemia is left untreated, severe symptoms may develop: confusion seizures loss of consciousness Call your doctor immediately if you have any of the following symptoms of hyperglycemia or high blood sugar: extreme thirst frequent urination extreme hunger weakness blurred vision If high blood sugar is not treated, a serious, life-threatening condition called diabetic ketoacidosis could develop. Call your doctor immediately if you have any of these symptoms: dry mouth nausea and vomiting shortness of breath breath that smells fruity decreased consciousness Metformin may cause other side effects: diarrhea bloating stomach pain gas constipation unpleasant metallic taste in mouth heartburn headache sneezing cough runny nose flushing of the skin nail changes muscle pain Some side effects can be serious: chest pain rash Continue reading >>

Jacksonville Pharmaceutical Litigation Attorneys

Jacksonville Pharmaceutical Litigation Attorneys

Jacksonville Pharmaceutical Litigation Attorneys Pharmaceutical Litigation and Medical Alerts Prescription drug companies market their products as effective, life changing and relatively safe. Many prescription drugs are capable of helping patients recover and heal from injuries and illnesses, but some have devastating side effects. When pharmaceutical companies willfully ignore side effects and rush their medications to market without proper trials or testing, people are put at risk. The experienced Jacksonville pharmaceutical litigation attorneys at Farah & Farah go after negligent corporations that put unsuspecting consumers in harms way. Pharmaceutical companies not only have a duty to manufacture drugs that are safe, but they also have the obligation to warn consumers regarding dangerous side effects that can be caused by these drugs. What Gives Rise to Pharmaceutical Litigation? Pharmaceutical litigation cases can stem from defectively manufactured drugs, improperly marketed drugs and drugs with dangerous side effects. Here are the most common reasons for pharmaceutical litigation: Defective manufacturing Contaminated or defectively manufactured drugs can cause devastating side effects. Some drugs that are normally safe can become tainted as a result of an error at the manufacturing facility, the bottling plant or during the shipping process. In other cases, the drug may have improper labeling. Improper marketing Marketing refers to warning labels, instructions for use and the advice provided to medical professionals. Drug manufacturers must inform doctors of the approved ways to use their products and consumers must be warned of any side effects they may face as a result of using the drug as intended. Dangerous side effects Just about all drugs have some possibl Continue reading >>

Invokana Injury | Invokana Lawsuit Attorney North Carolina - Law Offices Of James Scott Farrin

Invokana Injury | Invokana Lawsuit Attorney North Carolina - Law Offices Of James Scott Farrin

Smell of ketones on breath (similar to the smell of a pear) DKA is often, but not always, accompanied by high blood glucose levels, especially if a patient is taking Invokana, Farxiga, or other SGLT2 inhibitors and they are working. The version of DKA with fewer blood sugar-related side effects is known as euglycemic diabetic ketoacidosis and has all the same symptoms except for high glucose levels. FDA Warnings About Invokana, Farxiga, Xigduo, Jardiance, Glyxambi, Invokamet Although these drugs remain on the market, the FDA continues to issue warnings. According to a May 2015 FDA safety announcement , Invokana, and other SGLT2 inhibitors, may cause diabetic ketoacidosis. An American Diabetes Association article underscores this suspicion, stating, SGLT-2 inhibitors seem to be associated with euglycemic DKA and ketosis The European Medicines Agency , which is working in conjunction with the FDA, reported 101 cases of DKA in Type 2 diabetes patients, and the FDA has documented at least 20. Four months after the DKA warning, the FDA issued another one in September 2015 strengthening their warnings related to the increased risk of bone fractures. A May 2017 FDA Drug Safety Communication stated, Based on new data from two large clinical trials, the U.S. Food and Drug Administration (FDA) has concluded that the type 2 diabetes medicine canagliflozin (Invokana, Invokamet, Invokamet XR) causes an increased risk of leg and foot amputations. We are requiring new warnings, including our most prominent Boxed Warning, to be added to the canagliflozin drug labels to describe this risk. While the FDA is not yet requiring a warning to be added to all SGLT2 inhibitor labels, a panel at the European Medicines Agency (EMA the European equivalent of the FDA) has determined that these war Continue reading >>

Summer 2016 Drug Injury Lawsuits Report: Diabetes Medicines, Erectile Dysfunction Pills, And Heartburn Medications - Drug Injury Watch

Summer 2016 Drug Injury Lawsuits Report: Diabetes Medicines, Erectile Dysfunction Pills, And Heartburn Medications - Drug Injury Watch

Summer 2016 Drug Injury Lawsuits Report: Diabetes Medicines, Erectile Dysfunction Pills, And Heartburn Medications Current Product Liability Litigation Cases Involving Popular Drugs With Serious Side Effects That Are Starting To Gain More Attention (Posted by Tom Lamb at DrugInjuryWatch.com ) This article will feature three types of drug injury cases that are starting to gain some momentum in terms of the number of lawsuits filed against the responsible pharmaceutical companies in courts across the country. (1) Diabetes Medicines in the Sodium-Glucose Co-Transporter-2 (SGLT2) Inhibitors Class of Drugs Invokana (canagliflozin) Janssen Pharmaceuticals Invokamet (canagliflozin and metformin) Janssen Pharmaceuticals Farxiga (dapagliflozin) AstraZeneca Pharmaceuticals Xigduo XR (dapagliflozin and metformin extended-release) AstraZeneca Pharmaceuticals Jardiance (empagliflozin) Boehringer Ingelheim Pharmaceuticals Glyxambi (empagliflozin and linagliptin) Boehringer Ingelheim Pharmaceuticals Synjardy (empagliflozin and metformin hydrochloride) Boehringer Ingelheim Pharmaceuticals and Eli Lilly and Company These drug injury lawsuits primarily involve the following side effects: (2) Erectile Dysfunction (ED) Pills, Benign Prostatic Hyperplasia (BPH) Medicines, and Pulmonary Arterial Hypertension (PAH) Medications in the Phosphodiesterase 5 (PDE-5) Inhibitors Class of Drugs Adcirca (tadalafil) -- Eli Lilly and Company Cialis (tadalafil) -- Eli Lilly and Company Levitra (vardenafil hydrochloride) -- GlaxoSmithKline Stendra (avanafil) -- Vivus and Auxilium Pharmaceuticals These various prescription drug products have been linked to malignant melanoma skin cancer (but not basal or squamous cell skin cancers). (3) Heartburn Medicines and Acid Reflux Pills like Prevacid, Prilosec, an Continue reading >>

Class Action Lawsuits: Current Cases - Morgan & Morgan

Class Action Lawsuits: Current Cases - Morgan & Morgan

Our attorneys are investigating claims that victims of identity theft are being unfairly denied housing, employment, and credit because of... Morgan & Morgan has filed a lawsuit against the makers of the drug Kombiglyze XR because some of its users... Adults with Type 2 diabetes rely on prescription drugs like Farxiga (or its extended release counterpart, Xigduo XR), Glyxambi, and... Our attorneys at Morgan & Morgan have filed the biggest class action of all-time against online platform Yahoo over a... Our attorneys are investigating claims that consumer credit reporting agency Equifax’s negligent cybersecurity measures resulted in 143 million Americans’ personal... Continue reading >>

Chicago Prescription Error Lawyer | Defective Drug Lawyer

Chicago Prescription Error Lawyer | Defective Drug Lawyer

Actos is manufactured by Takeda Pharmaceuticals of Japan and marketed in the United States by Eli Lilly & Co. Since it was first approved by the Federal Drug Administration in 1999, doctors have widely prescribed Actos. According to the FDA, more than 2.3 million people filled prescriptions for Actos in 2010. Related medications include ActoPlus Met (pioglitazone and metformin), ActoPlus Met XR (extended release) and Duetact (glimepiride and pioglitazone). In June 2011 the FDA issued a warning about the increased risk of bladder cancer for individuals who have been taking Actos for more than one year. Signs of bladder cancer include: If you have any of these symptoms, you should immediately seek medical attention. If you or a loved one is taking or has taken Actos (pioglitazone hydrochloride) and have suffered bladder cancer or any other injurious side effects, you may have a legal claim against the maker and distributor of the drug. You might be entitled to monetary compensation for your medical expenses and pain and suffering because of Actos’ side effects. When a doctor prescribes a drug to treat or prevent illness, you should be able to expect the drug to work as intended. At the least, you want to feel confident that all possible complications and side effects associated with the drug are known and it is safe to take it. Unfortunately, that’s not always the case. Defective and dangerous pharmaceuticals are a major problem in Illinois and across the country. The danger can come from the composition of the drug and from the way it is marketed to doctors and patients. In a rush to make a profit, drug manufacturers may put drugs on the market without completing proper tests or disclosing known risks. If you believe that you or a loved one has been harmed by a defe Continue reading >>

Side Effects Of Metformin May Cause Problems With Thinking: Study

Side Effects Of Metformin May Cause Problems With Thinking: Study

The findings of a new study raises potential concerns about the side effects of meformin, suggesting that the popular diabetes drug may impair brain functions and cause users to experience problems thinking. Metformin is a widely used medication for treatment of type 2 diabetes, which is also known under the brand names Glumetza, Riomet, Fortamet and Glucophage. It is also part of several popular combination therapies, including the blockbuster medication Janumet, which combines metformin with the top selling diabetes drug Januvia. In a report published by the journal Diabetes Care, researchers compiled data from several different studies, including the Primary Research in Memory (PRIME) study; Australian Imaging, Biomarkers and Lifestyle (AIBL) study and data from the Barwon region of southeastern Australia. Researchers found that participants with diabetes performed worse on cognitive performance than those who did not have diabetes, with individuals taking a metformin drug performing significantly worse. More than 1,300 patients were evaluated who had Alzheimer’s disease, mildly impaired brain function and no cognitive impairments; along with a subset group which also had type 2 diabetes or impaired glucose intolerance. Patients who suffered a stroke or had neurodegenerative diseases other than Alzheimer’s were not included in the study. Patients with type 2 diabetes performed poorly on cognitive impairment tests and those who took metformin performed even worse. Researchers found metformin was associated with a vitamin B12 deficiency, which in turn resulted in impaired cognitive performance. Patients with vitamin B12 levels less than 250 pmol/L had the worst cognitive performance. Conversely, patients with type 2 diabetes taking metformin, but who also took calc Continue reading >>

Janumet Class Action Lawsuit Claims & Settlements - Lawyers & Attorneys

Janumet Class Action Lawsuit Claims & Settlements - Lawyers & Attorneys

This field is for validation purposes and should be left unchanged. This iframe contains the logic required to handle Ajax powered Gravity Forms. Janumet Lawsuit Claims & Settlements – Lawyers & Attorneys When someone discovers that he or she has contracted type 2 diabetes, that person needs to get to work to bring that health condition under control as quickly as possible.  Allowing type 2 diabetes to go unchecked can lead to much more serious health problems and eventually to an early death.  Generally speaking, people with type 2 diabetes need to maintain a healthy diet as well as some type of program of exercise with the help and oversight of their doctors.  Many also need to use medication that helps to bring their blood sugar levels back into safe balance. If you have suffered as a result of using this medication, you need to do what you can to level the playing field.  Seek the help of Janumet lawsuit lawyers who have held pharmaceutical companies accountable for the harm they have done to consumers.  There may be substantial cash compensation from claims and settlements, Contact the Hood National Law Group, today to schedule a free initial consultation. Given the prevalence of type 2 diabetes in the United States these days, medications for this problem have also become common.  One of the leading pharmaceutical companies in the world, Merck & Co., introduced Janumet several years ago and it produced generally positive results and an enormous amount of revenue for the company.  Unfortunately, reports of Janumet side effects eventually began to surface, prompting legal action and inquiries all over the country. Janumet contains two different medications: Sitagliptin and Metformin. Sitagliptin works by increasing levels of natural substances called incre Continue reading >>

Kidney Failure Drug Lawsuit

Kidney Failure Drug Lawsuit

Located in the lower middle back, your kidneys principle job is to regulate the fluid in your body, from water to blood to waste. Every 30 minutes, your kidneys filter your blood, removing salts, toxins, excess fluid and other waste, and send themto be flushed from your body. In this process, the kidneys also release a hormone that regulates blood pressure, activates vitamin D to maintain bone health and balance electrolytes, as well as mineral content in your blood. When one or both of your kidneys fails, the consequences can be grave. The loss of kidney function allows harmful wastes to accumulate in the body. Without the ability to eliminate excess fluid, salts and waste, your body begins to retain fluid in order to protect your other organs from toxicity. Over time, you may suffer from fluid build-up in the lungs, inflammation of the pericardium (lining over your heart) and heart arrhythmia. Without proper treatment, kidney failure can lead to permanent kidney damage, and even death. About 26 million people suffer from kidney failure each year, mostly thoseover the age of 65. While some of these cases are caused by existing health conditions, such as diabetes, many are the result of side effects from prescription and over-the-counter medications. Some cases of kidney failure are treatable, and kidney function may return to normal. In other cases, kidney failure may become chronic and irreversible. Kidney failure can bring a staggering economic burden. Annual medical payments for a patient with kidney disease start at around $15,000 in early stages, and can balloon to over $70,000 if the condition is critical. What Are the Most Common Kidney Failure Causes Kidney failure may be caused by several different factors, including: The dye (contrast) used in some scans and Continue reading >>

Invokana Compared To Metformin And Januvia

Invokana Compared To Metformin And Januvia

Every year, the American Diabetes Association updates its “standards of medical care in diabetes.” The 2016 edition, which is 119 pages long, is available here. The most important part for type 2 diabetics is found on page 61, which has a chart showing the therapies used to treat diabetes. First step is always metformin. Metformin is highly effective and low-risk, with side effects that are uncomfortable but typically not dangerous, like stomach pain, nausea, vomiting, or diarrhea. (Some patients, however, develop lactic acidosis.) When another drug is added to metformin (called “dual therapy”), there are a variety of options, including insulin, sulfonylureas, thiazolidinediones, DPP-4 inhibitors, GLP-1 receptor agonists, and SGLT-2 inhibitors. Invokana is a SGLT-2 inhibitor. Januvia is a DPP-4 inhibitor. SGLT-2 inhibitors like Invokana treat diabetes by acting on the kidneys, where they block the reabsorption of glucose, leading to less glucose in the blood. DPP-4 inhibitors treat diabetes by acting on the pancreas, where they help maintain higher levels of GLP-1, a hormone which triggers the production of insulin by the pancreas. As the American Diabetes Association says, “Drug choice is based on patient preferences, as well as various patient, disease, and drug characteristics, with the goal of reducing blood glucose levels while minimizing side effects, especially hypoglycemia.” Obviously, you should discuss all of these issues with your doctor, and carefully consider their advice. But when it comes to the “patient preferences,” what should you know? As the Invokana website points out, there was indeed a clinical trial where Invokana was shown to be modestly better than Januvia in reducing A1C levels. Similarly, a “retrospective matched-control coh Continue reading >>

Janumet Lawsuit | Janumet Lawyer, Janumet Attorney

Janumet Lawsuit | Janumet Lawyer, Janumet Attorney

The FDA is evaluating a potential signals of a serious risk and new safety information linking DPP4 diabetes drugs and rhabdomyolysis . This potentially life-threatening kidney side effect was identified by the FDA Adverse Event Reporting System (FAERS) between April and June 2017. UPDATE: FDA Warning Links Janumet and Severe Joint Pain August 28, 2015 The FDA is warning that Janumet may cause severe, disabling joint pain. Click here to read more. August 26, 2013 The U.S. Judicial Panel on Multidistrict Litigation (JPML) has centralized more than 50 lawsuits involving diabetes drugs into the U.S. District Court for the Southern District of California. Plaintiffs allege that Janumet caused their pancreatic cancer or the wrongful death of a family member. Click here to read more. March 15, 2013 FDA publishes Safety Alert regarding potential risk of pancreatic cancer. Click here to read more. February 26, 2013 Study published in JAMA Internal Medicine links Januvia (sitagliptin), Byetta (exenatide), and other GLP-1 diabetes drugs to a doubled risk of pancreatitis. Click here to read more. Janumet (sitagliptin / metformin) is used along with diet and exercise to treat patients with type-2 diabetes. It was approved by the U.S. Food and Drug Administration (FDA) in April 2007. Janumet manufactured by the drug company Merck, which created sitagliptin (sold alone as Januvia). Sitagliptin is the first anti-diabetic medication that works by inhibiting the enzyme DPP-4, which causes the pancreas to secrete extra insulin. More insulin in the body lowers blood-sugar levels. Janumet contains a combination of the following medications: Sitagliptin: DPP-4 inhibitor, causes the pancreas to secrete more insulin. Has been linked to an increased risk of acute pancreatitis, hemorrhagic pan Continue reading >>

Need A Diabetes Medication Lawyer? Heart Attack, Cancer, Amputations

Need A Diabetes Medication Lawyer? Heart Attack, Cancer, Amputations

The FDA released a drug safety communication in 2013 reporting that incretin mimetic drugs could potentially increase the risk of pancreatitis (inflamed pancreas) and could also cause pre-cancerous changes in the pancreas. The FDA cited a study, which was unpublished at the time, that found that the use of exenatide ( Byetta , Bydureon ) or sitagliptin ( Januvia , Janumet/Janumet XR , Juvisync) could double the risk of developing acute pancreatitis. A 2013 study in the medical journal Diabetes found that patients using incretin-related drugs had a higher rate of pancreatitis and pancreatic cancer than patients using other medications. In 2013, all federally filed incretin mimetic lawsuits claiming pancreatic cancer were combined into one court in the Southern District of California in the In re: Incretin Mimetics Products Liability Litigation MDL (Incretin Mimetic MDL). In November 2015, the MDL judge dismissed the cases on preemption grounds. The plaintiffs appealed and, in December 2017, the Ninth Circuit Court of Appeals reversed the MDL courts ruling reinstating hundreds of pancreatic cancer cases involving incretin mimetic drugs, which are now proceeding in the MDL. Byetta (exenatide) is a twice-daily injected medication that was approved by the FDA in 2005 for the treatment of type-2 diabetes. It helps control blood sugar levels by mimicking an incretin called glucagon-like peptide 1, thereby increasing insulin production. It was the first incretin-mimetic drug to hit the market. It was originally manufactured by Amylin Pharmaceuticals which was later purchased by Bristol-Myers Squibb in 2012. Eli-Lilly co-sold Byetta until 2011. Then in 2014, AstraZeneca acquired Bristol-Myers Squibb. Byetta has been linked to an increased risk of pancreatic cancer in some studi Continue reading >>

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