Question About Keto And Metformin?
Raynne413 Posts: 1,524Member, Premium Member Posts: 1,524Member, Premium Member I'm on metformin as well, and I would be curious as to what your doctor tells you, if you wouldn't mind reporting back, because I was wondering the same thing. I take my metformin first thing in the morning, after my lunch around 3, and then at bedtime, and I've noticed that by the time I get home from work in the afternoon, around 5, I'm usually feeling sick to my stomach, tired, and shaky, so now I'm wondering if it is from my afternoon dose. KnitOrMiss Posts: 9,918Member Member Posts: 9,918Member Member My doctor recommended staying on Met as it helped with my insulin resistance, but as I added more dairy, it wasn't worth the dumping complication for me personally. Not everyone has that. Since I am doing well staying with my diet plan, and my IR is minimal, I'm able to manage it to 90-95% of the Metformin levels through my Keto diet. I don't believe there is much risk of low blood sugar with it (there was some research a while back), but after adjusting dietarily, you may be able to reduce or stop your dosages eventually. But you may not. Some people's insulin resistance don't get better using diet or it may take a long LONG time to restore your metabolism's "health." So this is very much and individual situation, based on how your body responds. However, if you struggle to stay on plan, it is unlikely that you would ever be able to stop this medication, because low carb eating requires patience and persistence for success. It's not a quick fix... Metformin only works, as I understand it, by making your body see the insulin it has already created instead of making more and continuing the raging hunger cycle that is IR. So since Metformin doesn't create or increase insulin, there should n Continue reading >>
Metformin In Combination With A Ketogenic Diet As An Effective Cancer Protocol
Metformin in Combination with a Ketogenic Diet as an effective Cancer Protocol Metformin originates from the French lilac or goats rue (Galega officinalis, see picture below), a plant used in folk medicine for several centuries including for diabetes and other ailments. Today, the use of Metformin has been shown to decrease the risk of cancer. (1) Metformin has exhibited a strong and consistent antiproliferative action on several cancer cell lines, including breast, colon, ovarian, pancreatic, lung, and prostate cancer cells. (See Exhibits A & B below). These in vitro studies were generally completed by preclinical studies showing a reliable antitumoral effect in various mouse models. In addition, the first clinical trials demonstrated a beneficial effect in breast and colon cancer. (2) Metformin has also shown to increase radiotherapys efficiency. (3) COMBINING A LOW GLUCOSE KETOGENIC DIET WITH METFORMIN Would it be possible to potentiate metformins anti cancer impact within a low glucose environment ? It has been shown that different cancer cells exhibit altered sensitivity to metformin treatment. (CF Exhibit B) One reason for this discrepancy is the common cell culture practice of utilizing high glucose. However, when glucose is lowered, metformin becomes increasingly cytotoxic to cancer cells. In low glucose conditions ranging from 0 to 5 mM, metformin was cytotoxic to breast cancer cell lines MCF7, MDAMB231 and SKBR3, and ovarian cancer cell lines OVCAR3, and PA-1. (4) Recent findings suggest that lowering glucose potentiates metformin induced cell death by reducing metformin stimulated glycolysis. Additionally, under low glucose conditions metformin significantly decreased phosphorylation of AKT and various targets of mTOR, while phospho-AMPK was not significantl Continue reading >>
Carbohydrate Restricted Diet In Conjunction With Metformin And Liraglutide Is An Effective Treatment In Patients With Deteriorated Type 2 Diabetes Mellitus: Proof-of-concept Study
Go to: Abstract Type 2 diabetes mellitus is a chronic progressive disease. During the course of the disease intensive treatment is often necessary resulting in multiple interventions including administration of insulin. Although dietary intervention is highly recommended, the clinical results of the widely prescribed diets with low fat content and high carbohydrates are disappointing. In this proof-of-concept study, we tested the effect of dietary carbohydrate-restriction in conjunction with metformin and liraglutide on metabolic control in patients with type 2 diabetes. Forty patients with type 2 diabetes already being treated with two oral anti-diabetic drugs or insulin treatment and who showed deterioration of their glucose metabolism (i.e. HbA1c >7.5), were treated. A carbohydrate-restricted diet and a combination of metformin and liraglutide were instituted, after stopping either insulin or oral anti-diabetic drugs (excluding metformin). After enrollment, the study patients were scheduled for follow-up visits at one, two, three and six months. Primary outcome was glycemic control, measured by HbA1c at six months. Secondary outcomes were body weight, lipid-profile and treatment satisfaction. Thirty-five (88%) participants completed the study. Nearly all participating patients experienced a drop in HbA1c and body weight during the first three months, an effect which was maintained until the end of the study at six months. Seventy-one percent of the patients reached HbA1c values below 7.0%. The range of body weight at enrollment was extreme, reaching 165 kg as the highest initial value. The average weight loss after 6 months was 10%. Most patients were satisfied with this treatment. During the intervention no significant change of lipids was observed. Most patients wh Continue reading >>
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What’s The Difference Between Ketosis And Diabetic Ketoacidosis?
Ketosis and ketoacidosis sound similar and are sometimes confused, but don’t mistake these conditions for one another. These involve two different sets of circumstances with considerably different outlooks. Both are triggered by an increase of ketones in the body, which are acids released into the bloodstream when the body burns fat for energy instead of carbohydrates. But it’s how the body responds to this increase that sets ketosis and ketoacidosis apart from each other. RELATED: How to Tell the Difference Between Good and Bad Carbs What Is Ketosis and How Does the Process Work? “Ketosis is a natural state that occurs when you start to metabolize fat instead of sugar,” says Michael Greenfield, MD, endocrinologist and chief medical officer at El Camino Hospital in Palo Alto, California. “It occurs often when people fast and use up the stores of sugar in their body." To understand ketosis, it helps to understand how the body burns energy. Carbohydrates and fat are both energy sources, and the body typically burns carbs (sugar or glucose) first, and then fat. If there aren’t enough carbohydrates in your system, it begins to break down fat for energy, which puts your body into a state of ketosis. While in this state, the body becomes a fat-burning machine. For this reason, ketosis is the goal of many diets, particularly those that restrict carbohydrate intake and rely on fat for energy, such as the ketogenic diet. Understanding the Relationship Between the Ketogenic Diet and Ketosis “The ketogenic diet is a high-fat (60 to 80 percent of your total daily calories), moderate-protein (10 to 15 percent of your total daily calories), and low-carbohydrate diet (less than 10 percent of your total daily calories) that forces your body into ketosis, where it burns fa Continue reading >>
Can I Have Grapefruit While Taking Metformin?
Many medications, such as statins and some antihistamines, have a negative interaction with grapefruit. Metformin is used in treatment of type 2 diabetes. Does having grapefruit while taking metformin lead to adverse side effects? There’s limited research, but here’s what you need to know. Metformin is a drug that’s prescribed to treat type 2 diabetes. People with type 2 diabetes can’t use insulin normally. This means they can’t control the amount of sugar in their blood. Metformin helps people with type 2 diabetes control the level of sugar in their blood in several ways, including: decreasing the amount of sugar your body absorbs from food decreasing the amount of sugar produced by your liver increasing your body’s response to the insulin that it makes naturally Metformin can rarely cause a very serious and life-threatening condition called lactic acidosis. People with liver, kidney, or heart problems should avoid taking metformin. There are more than 85 drugs that are known to interact with grapefruit. Of these drugs, 43 of them can lead to serious adverse effects. All forms of grapefruit — including freshly squeezed juice, frozen concentrate, and the whole fruit — can lead to drug interaction. Some of the chemicals found in grapefruit can bind to and inactivate an enzyme in your body that’s found in your intestines and liver. This enzyme helps break down the medication you take. Normally when you take a drug orally, it’s broken down slightly by enzymes before it reaches your bloodstream. This means that you receive a little less of the drug in your bloodstream than the amount you initially consumed. But when the enzyme is inhibited — as it is when it interacts with the chemicals in grapefruit — there’s a dramatically larger amount of the dr Continue reading >>
Research Shows Keto Diet Can Improve Effectiveness Of Cancer Drug Metformin
Erythritol Sweetener - Leaving sugar behind is a piece of cake! Monk Fruit + Erythritol - As sweet as sugar & 100% guilt-free! Powdered Erythritol - 0-carb & tastes like confectioners' sugar! Veggie Spiralizer - Make healthy veggie noodles in minutes! Research Shows Keto Diet Can Improve Effectiveness of Cancer Drug Metformin Amber Bogdanowicz | News , Science | Updated A recent study found the drug Metformin to be effective against thyroid cancer in the absence of glucose. More importantly, a ketogenic diet may improve the effectiveness of your treatment with Metformin. Metformin is a drug used to lower blood sugar, typically in patients with type 2 diabetes. Its also known to inhibit thyroid cancer cell growth. In recent years, the newest approach to tackling cancer is targeting cancer cell metabolism. 1 With Metformin as the weapon of choice, studies have focused on Metformin in the treating of breast, ovarian, lung, colorectal, and pancreatic cancers. However, research shows that it doesnt act the same in everyone. Bikas et. al. considered how Metformin might act differently among patients with thyroid cancer in the presence of glucose. They found that thyroid cancer cells grown in environments with high glucose did not continue to grow when placed in low glucose environments; in fact, thyroid cancer cells died. Essentially, the effectiveness of Metformin was improved by a lack of glucose. Why does this work? Well, cancer cells have to basically reprogram their environments so that they can get the things they need to metabolize in order to produce energy. The way Metformin works is that it inhibits something called mTORC1 or mammalian target of rapamycin complex 1. 2 That complicated term basically refers to a specific pathway that is responsible for metabolism, g Continue reading >>
Who Should Not Follow A Keto Diet
Some precautions must be made clear; In order to follow this or any other diet program, you must first undergo a health screen to rule out any rare conditions or contraindications with your health or medications with a ketogenic diet. this diet is not appropriate for people with any stage of kidney disease, or any pre-existing liver, pancreatic or kidney issues or conditions. Some rare conditions such as Muscular Dystrophy and other conditions may complicate and severely distress the pancreas, liver or kidneys. this diet is not appropriate under any circumstances if you currently have blood sugar issues such as hypoglycaemia or type 1 diabetes. It may or may not be appropriate if you have type 2 diabetes and on any medications for diabetes, and will require doctor supervision. this diet may not be appropriate or safe for people who are pregnant, nursing or who have Gestational Diabetes. this diet may not be appropriate for anyone suffering or recovered from an eating disorder. by agreeing to these terms, you are affirming that you do not have any of the above medical conditions, and you are proceeding at your own risk, with your doctor's approval. There are also other considerations such as the possibility that you may need to rapidly change your medications while on this diet. If you are considering the Ketogenic Diet, it is important to speak with your physician or endocrinologist, especially if you have any kind of medical condition, to develop a plan. Before starting any diet, you should speak to your doctor. You must not rely on the information on this website as an alternative to medical advice from your doctor or other professional healthcare provider. If you have any specific questions about any medical matter, you should consult your doctor or other professiona Continue reading >>
Reversing Type 2 Diabetes With Nutritional Ketosis
Virta is a science-based online specialty medical clinic using continuous remote monitoring and intensive coaching to help our patients reverse type 2 diabetes and prediabetes. A unique contributor to our success in this is harnessing and sustaining the metabolic benefits of nutritional ketosis. Admittedly, reversing diabetes is a rather bold goal. By way of contrast, the American Diabetes Association defines type 2 diabetes as a progressive disease whose course at best can be slowed by lifestyle change and medication. Based upon solid science—some old and some new—we beg to differ. Perhaps it’s time for a paradigm change. There are few times in the lives of medical scientists where we have the opportunity to change the course of a major medical disease; and even fewer cases where we actually succeed in doing so. In 1920, Banting’s discovery that injected insulin could control type 1 diabetes (T1D) was such an event. As a result, over the last century, millions of people with T1D have achieved long and productive lives; whereas before 1920 most of them would have succumbed to this insulin-deficiency disease within less than a year. Type 2 diabetes (T2D), on the other hand, is a very different disease that affects hundreds of millions of people. It responds very poorly to injected insulin. Whereas T1D patients cannot make insulin, people with T2D typically make lots of insulin but are resistant to insulin’s effects across a variety of cellular functions. Despite these facts having been known for 5 decades, we are taught that the core components of T2D management are to force the body to make even more insulin or to inject more insulin to overcome the insulin resistance that characterizes this disease. But in study after study, intensive management of type 2 dia Continue reading >>
Metformin In Keto Diet - Can I Take | Practo Consult
Can i take metformin to treat PSOD while starting keto diet (low carb low proteins high fat)My blood sugar level is normal My BMI is 45 Depends on ur harmonal assessment along with blood glucose levels ,also we need to see Ur Ultrasound report to see the size an position of cyst ,for any further information or assistance you may get back to us on a direct Consulting. Gynaecological Endoscopist 8 yrs exp Delhi For PCOS You need to have assessment of ur metabolic parameters If they suggest any derangement then only metformin is startedSeek paid online consultation for personalised assessment Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The internet is not a doctor and neither are you. Chat with a real doctor about your health. Is 10mg of metformin once a day enough to induce my period in a week? I was recently diagnosed with polyc ... Read More I delivered my baby 10 months back and for the last 2 months, I'm getting periods that last for more than ... Read More I have been diagnosed with PCOS and I got my first period after 8-9 months after using Metformin. How muc ... Read More Can i take metformin to treat PSOD while starting keto diet (low carb low proteins high fat) Period cycle of my wife is delayed by 1 week. We have used protection as well. Please suggest some medici ... Read More Continue reading >>
How The Ketogenic Diet Works For Type 2 Diabetes
Special diets for type 2 diabetes often focus on weight loss, so it might seem crazy that a high-fat diet is an option. But the ketogenic (keto) diet, high in fat and low in carbs, can potentially change the way your body stores and uses energy, easing diabetes symptoms. With the keto diet, your body converts fat, instead of sugar, into energy. The diet was created in 1924 as a treatment for epilepsy, but the effects of this eating pattern are also being studied for type 2 diabetes. The ketogenic diet may improve blood glucose (sugar) levels while also reducing the need for insulin. However, the diet does come with risks, so make sure to discuss it with your doctor before making drastic dietary changes. Many people with type 2 diabetes are overweight, so a high-fat diet can seem unhelpful. The goal of the ketogenic diet is to have the body use fat for energy instead of carbohydrates or glucose. A person on the keto diet gets most of their energy from fat, with very little of the diet coming from carbohydrates. The ketogenic diet doesn’t mean you should load up on saturated fats, though. Heart-healthy fats are the key to sustaining overall health. Some healthy foods that are commonly eaten in the ketogenic diet include: eggs fish such as salmon cottage cheese avocado olives and olive oil nuts and nut butters seeds The ketogenic diet has the potential to decrease blood glucose levels. Managing carbohydrate intake is often recommended for people with type 2 diabetes because carbohydrates turn to sugar and, in large quantities, can cause blood sugar spikes. If you already have high blood glucose, then eating too many carbs can be dangerous. By switching the focus to fat, some people experience reduced blood sugar. The Atkins diet is one of the most famous low-carb, high-p Continue reading >>
Dr. Adam Nally - Using Metformin With A Ketogenic Diet
Hello, my name is Dradamnally. I'm a board certified family physician board certified in obesity medicine specialist and I'm currently in Austin, Texas at a a medical conference at the Keto conference that starts tomorrow and I've had a number of questions over the last two weeks. Come up about a metformin there's a couple of studies that came out recently about Metformin and it's used with Ketogenic diet its use with exercise with diabetes and things like that and a lot of people asking some questions So I want to try to clarify some of the information about Metformin how we use it in the office. What I would recommend people consider and how to talk to their doctor about use of metformin garage, two luxury Control exercise and losing weight in that capacity so important understand that let me put up on the screen who I am. My name is Doctor Adam Nally. I'm a board certified family physician in obesity medicine specialist has been in practice for about 20 years I've been specializing in using Ketogenic lifestyle for about 15 years in my practice. I will vote myself and thousands of patients and so I wanted to give you information there I got a little bit of time delay with my software on Facebook. This is rolling live to Facebook right now So good evening you guys as you sign in if you're new to the broadcast, please put one in the box and then let me know where you're from So I I got to feel for work Coming in from but I'll try to answer some questions from the end of this. I just want to give some brief information This is fairly basic and it won't take too long first of Metformin is a a great medication. I use it with hundreds of patients in my practice. I should probably thousands of patients it's a drug that's called a big one eye that was designed to help the wa Continue reading >>
Approach Keto (very Low Carb) Diet With Caution
In a second study,2 a Harvard-led research team evaluated the benefit of a ketogenic diet in both children and adults with type 1 diabetes despite concerns about a possible negative effect on growth and development in children following such a restricted diet.These researchers report "exceptional" glucose controlwith little adverse effects. However, the participants were recruited from a closed Facebook group, TypeOneGrit, for people who follow a diet and diabetes program based on the recommendations in the Diabetes Solution,3a book by Richard K Bernstein, MD, who devised this program tomanage his own type 1 diabetes. The ketogenic diet focuses on lean meat and lots of vegetables to promote weight loss. Too good to be true? Many experts are pushing back and raising questions about whether the keto diet itself is responsible for the improvement in weight and blood sugar or maybe the dieters' successes are due to other components of the research methods, such as lifestyle differences or physiological changes. "First, the studies are too small to make sense of the differences between the groups," says Michael J Gonzalez-Campoy, MD, PhD, medical director and CEO of the Minnesota Center for Obesity, Metabolism, and Endocrinology, in Eagan, Minnesota. And, it's important to recognize that both study teams acknowledge that as exciting as their findings seem,a large,randomized controlled trial is still needed to more closely assess a variety of components that may be contributing to the successes found in both studies before the findings can be recommended to anyone outside the study groups1,2he says. "We recommend against 'dieting',which is invariably a short-termsolution," Dr. Gonzalez-Campoy, tells EndocrineWeb, "and since weight loss may be accomplished by a reduction in c Continue reading >>
Is Keto The Cure For Type Ii Diabetes?
A keto-compliant salad featuring collard greens and bacon crumbles. Photo courtesy of Brian Ambrozy/FlickrType II diabetes is one of America's most ubiquitousand expensivechronic diseases. Patients often require a suite of pharmaceutical products to manage high blood glucose levels, and the complications that arise over the long term, ranging from loss of vision and limbs to kidney failure and coronary artery disease, strain the resources of patients, their families, and the health care system. The financial strain on insurance companies, employers, and Medicaid and Medicare is even more enormous. A 2013 study in the American Journal of Preventive Medicine put the lifetime direct medical costs for type II diabetes treatment at $124,000 for patients diagnosed in middle age. With nearly 30 million Americans affected by the disease, the American Diabetes Association estimates the national cost of direct diabetes care to be roughly $176 billion per year. But unlike type I diabetes, which is an autoimmune disorder that destroys insulin-producing cells in the pancreas, type II diabetes is a lifestyle disease, and thus reversible. Over time, people with type-II diabetes can be made more receptive to their own insulin, which in turn allows their bodies to effectively clear glucose from the blood without insulin medication. The trick for the vast majority of type II patients is as simple as losing weight. ("The relationship between obesity and diabetes is of such interdependence that the term 'diabesity' has been coined," two diabetes researchers wrote in 2005.) But that "trick" is actually pretty hard. Permanent weight loss without bariatric surgery is practically impossible at the population level. A 2014 study by Kaiser Permanente that looked at incidents of non-surgical dia Continue reading >>
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Will Metformin Lead To Faster Weight Loss When Used In Conjunction With A Low Carb Or Keto Diet?
afefdrvuqb BbcyIFFqI NjxLaGheclRanKXoHhZPMaYlFrakMtMed Can your DNA tell you which foods are the best for your personal diet? I've heard that some DNA tests can tell you if you need high/low c... The short answer is yes. Based on your DNA, your body is better suited for some foods than others. This company found that 45% of peoples genes need a high carb diet, 47% need ... Answered Nov 23, 2019 Author has 316 answers and 61.8k answer views Metformin knwn t b marginally beneficial fr weight loss. Hw d t d that? Metformin stimulates th breakdown f fat. It l lowers ur blood glucose, whh leads t l insulin needing t b released. Sn insulin a fat storing hormone, lower insulin levels mk ur stored bd fat mr accessible. Yu hv plenty f energy stored fat, b making th stores accessible ur metabolism n rl n mr fat fr energy; th helps normalize appetite nd lose excess bd fat. An overproduction f insulin n eventually lead t insulin resistance. Th th phenomenon wh... Metformin knwn t b marginally beneficial fr weight loss. Hw d t d that? Metformin stimulates th breakdown f fat. It l lowers ur blood glucose, whh leads t l insulin needing t b released. Sn insulin a fat storing hormone, lower insulin levels mk ur stored bd fat mr accessible. Yu hv plenty f energy stored fat, b making th stores accessible ur metabolism n rl n mr fat fr energy; th helps normalize appetite nd lose excess bd fat. An overproduction f insulin n eventually lead t insulin resistance. Th th phenomenon whrb cells bm l nd l responsive t insulin mr nd mr f t needed t perform t action. Hn, th insulin-lowering fft f Metformin ll beneficial fr people wh r insulin resistant. Diabetics arent th nl n wh r insulin resistant. Mn people l hv prediabetes (often wthut knowing it) r m kind f underlying insulin resistance. Hvng Continue reading >>
What Is Metformin? (for Weight Loss, Diabetes And)
Metformin is the most popular drug for type 2 diabetes. Its unique because unlike most other drugs it lowers blood sugar without increasing insulin secretion. Other diabetic drugs may cause you to secrete more insulin to lower blood sugar levels. This will only aggravate the underlying problems of insulin resistance and weight gain [ 1 ]. Metformin is also used to treat polycystic ovary syndrome (PCOS), a condition of insulin resistance largely. Metformin is a mild insulin-sensitizing drug which may counteract insulin resistance. In this manner, it is thought to potentially lower the risk of endometrial cancers that are three times higher in women with PCOS. Recently, it gained a lot of attention as an anti-aging drug with lifespan extension potential. So is Metformin really this wonder drug? And how does it do all that its said to do? Metformin lowers glucose production in the liver and makes muscle cells more sensitive to insulin. These muscle cells can thus take up glucose more easily. So it reduces baseline fasting blood glucose levels in the first place. And, if blood glucose shoots up after a carb-rich meal say, itll also help lower those post-meal glucose spikes. Through this double impact on blood glucose levels, metformin can mitigate some of the damage caused by diabetes control for a while [ 2 , 3 ]. Metformin is usually the first drug prescribed to newly diagnosed diabetes patients. It cannot, however, stop the progression of diabetes as it doesnt address the underlying causes. And the dose is often increased over time and combined with other medications. When given to patients with prediabetes, metformin can decrease the risk to become diabetic. The medication is, however, less effective than lifestyle interventions. While metformin is a good option and ad Continue reading >>