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Metformin And High Uric Acid

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Effect Of Diacerein As An Add-on To Metformin In Patients With Type 2 Diabetes Mellitus And Inadequate Glycemic Control

Objective To evaluate the effect of diacerein as an add-on to metformin in patients with type 2 diabetes mellitus (T2DM) and inadequate glycemic control. Materials and methods A randomized, double-blind, placebo-controlled clinical trial was carried out on 12 patients with T2DM and inadequate glycemic control [glycated hemoglobin A1c (A1C) ≥ 7%] with metformin as monotherapy (≥ 1500 mg per day) for at least the previous 90 days. Fasting and postprandial glucose were measured before and after the pharmacological intervention. A1C, lipid profile, creatinine and uric acid were also evaluated. After randomization, all patients continued with their dose of metformin. Six subjects received placebo and the other six volunteers took diacerein. Data were tested using the Wilcoxon signed-rank, Mann-Whitney U and chi-square tests. The Institutional Ethics Committee approved the study protocol. Results After 90 days of diacerein as an add-on to metformin, there was a significant decrease in fasting glucose (196 ± 79 vs. 149 ± 70 mg/dL, p < 0.05), postprandial glucose (262 ± 99 vs. 187 ± 70 mg/dlL, p < 0.05) and A1C (8.4 ± 2.0 vs. 6.7 ± 1.7 %, p < 0.05). Conclusions Diacerein as an ad Continue reading >>

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Popular Questions

  1. rascaldt00

    Hello,
    In May 2011 I was diagnosed with high blood sugar - 294 and an A1C of 12.1. Doctor prescribed 500 mg of metformin once a day - diet and exercise. I had my 3 month check up and BG - 94 and A1C 5.9. Now the doctor wants to take me off from metformin and just continue my diet and exercise. I have also lost 40 pounds. To tell you the truth, I am a little nervous to quit the metformin. Can someone please let me know if this is common.

  2. kchammmy

    I would say it is.
    I have lowered my numbers significantly and its time to maybe see what less meds will do. Im nervous about it. But we shouldnt be....we can always get back on the meds if we need to. Our "nervousness" could be becauuse we want so badly NOT to need the meds....going off them will force us to find out!

  3. jillybean

    First, congrats on that progress!
    I think it's normal to be nervous, but it's just one of those things where you never know 'til you try! If it doesn't work out, it'll still be there if you need it

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