Metformin - For The Dermatologist
We are experimenting with display styles that make it easier to read articles in PMC. The ePub format uses eBook readers, which have several "ease of reading" features already built in. The ePub format is best viewed in the iBooks reader. You may notice problems with the display of certain parts of an article in other eReaders. Generating an ePub file may take a long time, please be patient. Metformin though primarily an antidiabetic drug, has found to play an important role in a number of cutaneous disorders. Because of its role in improving hyperinsulinemia, it has proven beneficial in hormonal acne, hidradenitis suppurativa (HS) and acanthosis nigricans. Its antiandrogenic properties further serve as an add-on to the conventional management of hirsutism associated with polycystic ovarian syndrome. Very recently, systemic usage of metformin for psoriasis and cutaneous malignancies has shown promising results. Interestingly, metformin has also been topically used in hyperpigmentary disorders with pertinent levels of improvement and happens to be the most recent addition to the list of dermatologic indications. Though an oral hypoglycemic agent to begin with, metformin today has proven to be a boon for dermatologists. KEY WORDS: Hyperandrogenism, hyperinsulinemia, hyperpigmentary disorders, metformin, skin cancer (dimethylbiguanide) today is a widely used drug prescribed for diabetic patients. The history of metformin dates back to the usage of the herb Galega officinalis. This herb was found to be rich in a substance called guanidine with blood-glucose-lowering properties, which later was discovered to be the chemical basis of metformin. Though an antidiabetic drug to begin with, metformin has proven to be a drug of importance, in a number of cutaneous indications. Th Continue reading >>
Metformin Acne Treatment
Metformin is an anti-hyperglycemic drug used to treat patients with type 2 diabetes and to treat women with polycystic ovary syndrome (POCS) and hirsutism, excessive or unwanted facial or body hair. Metformin also has benefits in treating acne in patients with hyperandrogenism or excessive production of androgen. Hyperandrogenenism causes acne vulgaris, which is the increased accumulation of oil and bacteria in the skin pores and the formation of papules, pustules or nodules. Video of the Day Metformin was approved by the Food and Drug Administration (FDA) in 1995 only for the treatment of type 2 diabetes. According to the Northwestern University website, metformin is not FDA approved to treat POCS symptoms. However, treatment with metformin benefits women suffering with POCS because of its effect in reducing insulin, testosterone and glucose levels. These effects help to reduce the symptoms of acne, hirsutism, abdominal obesity and amenorrhea that are all symptoms of POCS. Metformin Effects on Acne Metformin is used to treat acne in specific conditions such as PCOS, which causes serious hormonal imbalances that cause acne outbreaks. Metformin works to balance the hormones and control the acne outbreaks. The side effects of metformin include gastrointestinal symptoms of nausea and vomiting, abdominal bloating and diarrhea. These symptoms may be minimized by starting with a low dosage that is gradually increased over a few weeks. Metformin will also affect the absorption of vitamin B12; long-term treatment with metformin may lead to anemia. A rare and serious side effect of metformin is lactic acidosis, too much acid in the body. Therefore, it’s important to have a serum creatinine test prior to starting metformin therapy and to have liver enzymes levels monitored ever Continue reading >>
- Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE)
- Is Metformin an Effective Treatment for Type 2 Diabetes?
- Is It Time to Change the Type 2 Diabetes Treatment Paradigm? No! Metformin Should Remain the Foundation Therapy for Type 2 Diabetes
Could Metformin Actually Make Insulin Resistance Worse?
Polycystic Ovarian Syndrome, or PCOS, and Insulin Resistance (IR) often occur simultaneously. While the connection between these two conditions is, as of yet, not entirely clear, researchers have determined that IR can lead to PCOS and diabetes.1 Metformin, or Glucophage, is commonly prescribed for both of these disorders, as it is assumed to reduce IR and improve the symptoms associated with it (such as high blood sugar). Understanding the Fine Print Although Metformin claims to reduce IR, current labeling laws do not require pharmaceutical companies to reveal how their products achieve results, they simply must accurately represent what kind of results can be expected from their medications.2 This pharmaceutical, in particular, lowers blood sugar using less insulin, which has been taken to mean that it reduces IR.2 This may not be the case. How Does Metformin Really Work? Diabetes Update, a blog that reviews diabetes medications and treatment options, has published some interesting findings pertaining to how Metformin actually improves diabetes and PCOS. A study conducted on mice has suggested that the drug lowers blood sugar not by reducing IR, but by activating a gene that does not function properly. This gene, which is located in the liver, stops the production of glucose.2 According to the findings of this study, this pharmaceutical works on a deeper level than simply increasing the sensitivity of the body’s cells to insulin—it actually addresses a genetic issue. While the end result remains the same, blood sugar is lowered; the cells of the body are no more sensitive to insulin than they were before. Although the desired end result is achieved, this doesn’t necessarily heal the body in the same manner as decreasing IR would. Determining Which PCOS Medicine Continue reading >>
For Pcos, 13 Side Effects Of Metformin You Should Know About
Did you know that 10%- 25% of women who take Glucophage just don't feel well? They experience a general malaise, fatigue and occasional achiness that lasts for varying lengths of time. Malaise a warning signal for your doctor to closely monitor your body systems, including liver, kidneys, and GI tract. About one third of women on metformin experience gastrointestinal disturbances, including nausea, occasional vomiting and loose, more frequent bowel movements, or diarrhea. This problem occurs more often after meals rich in fats or sugars, so eating a healthier diet will help. The symptoms lessen over time, so if you can tolerate the GI upset for a few weeks, it may go away. Some women have found it helps to start with a very low dose and gradually increase it. Most people think that aside from possible gastrointestinal upset, there are no side effects from taking metformin, and thus you can take it for a very long time. This is not true! The sneakiest side effect of all is a vitamin B12 insufficiency. A substance formed in the stomach called "intrinsic factor" combines with B12 so that it can be transferred into the blood. Metformin interferes with the ability of your cells to absorb this intrinsic factor-vitamin B12 complex.(12) Over the long term, vitamin B12 insufficiency is a significant health risk. B12 is essential to the proper growth and function of every cell in your body. It's required for synthesis of DNA and for many crucial biochemical functions. There is also a link between B12 insufficiency and cardiovascular disease. According to some research, 10%-30% of patients show evidence of reduced vitamin B12 absorption. The Hospital de Clnicas de Porto Alegre in Brazil has shown that one of every three diabetics who takes metformin for at least a year have evide Continue reading >>
10 Facts About Metformin And Pcos
Polycystic ovary syndrome (PCOS) is a relatively common hormonal disorder that is one of the leading causes of infertility. Some women who have PCOS develop insulin resistance. This occurs when the cells of the body don’t respond well to a hormone known as insulin. Insulin allows the cells to take sugar (glucose) from the blood. If the cells don’t take in this sugar it leads to higher levels of glucose and insulin circulating through the body in the bloodstream. This, in turn, leads to increased levels of androgens (male hormones) which cause the classic symptoms of PCOS such as excess hair growth and more importantly in terms of fertility – lack of ovulation. Getting pregnant with PCOS can be possible with the right diagnosis and treatment plan. Here are the Top 10 facts about metformin use in PCOS patients: 1) Metformin is a medication that is primarily used to treat type 2 diabetes. It is marketed in the US under the names Fortamet, Glucophage, Glucophage XR, Glumetza and Riomet. It is available as a tablet, extended-release tablet and a liquid. 2) With infertility patients, it is used not because the women with PCOS have diabetes (although they do have an increased risk of developing this disease), but because it acts on improving use of insulin by the cells of the body and therefore reducing the level of insulin in the blood. This can lead to improved ovulation, more regular menstrual cycles as well as a reduction in excessive hair growth, acne and weight gain. It may also slow down or prevent the development of type 2 diabetes later in life. 3) To determine if it would be helpful for a patient with PCOS to use Metformin, they are given a 2 Hour Glucose Tolerance Test. First, a fasting blood sample is drawn to determine a baseline glucose level. The patient t Continue reading >>
Will Stopping Metformin Cause Acne?
Home Q & A Questions Will stopping metformin cause... acne , polycystic ovary syndrome , metformin , skin , prescription I have been on metformin (500mg once a day) going on 3 years for PCOS. I forgot to get my prescription refilled and I haven't taken metformin for 5 days. I noticed last night very blotchy skin and a few breakouts on my face..nothing like I've had since I started metformin. Is this a normal symptom for being off of the medicine for 5 days? Also, would it be worth asking my doctor to up my dosage? I have experience weight gain and still have unwanted facial hair. Any advice will help! ahearington;;;; please call the pharmacy and get back on that you are playing with a timebomb just stoping even if its a low dose as far as the the blotches and breakout i can't find it but im sure that is a high possibility because when people that need this medication are put on it most the time this clears up... But you just never stop this drug like this please get it filled and back on it..As far as increasing the dose i would not at this time you need to get back to regular like a month and then go see your doctor and talk about if a increase would do you any good... okay please fill and start you don't need any problems or more chuck1957 Continue reading >>
Verity Discussion Board
Excess hair, hair loss, acne, skin tags etc... Discuss! Moderators: thebuzz, Northfifer, Sammi, Hols969, DawnyB, purplestar, loachy, Mrs Wilko, Lutzomyia [Sorry I have posted this twice as first time I put it in the wrong topic area] I have been taking Metformin for just under 3 weeks, not very long I know, but I have noticed in the past few weeks my acne has got really noticeably worse. I have always had greasy skin and blocked pores and a few spots but just recently my face gets really shiny within half an hour of washing, and I'm getting lots of white spots and painful lumps around my nose and chin, and some red angry ones on my face and chest. It is worse than I've ever had before. I use benzoyl peroxide which has previously been quite effective but doesn't seem to be working any more (can't use much more than this as am TTC). I've also noticed my hair has become really bad condition - strawlike and breaking off. I don't know if all this is just co-incidence or if it could be linked to the metformin? I have never had my insulin tested and do not know if I am actually IR or not, my gynae just put me on the met as a first line treatment before trying Clomid if this doesn't work. I haven't had any periods yet (nothing since I came off the pill 10 months ago) so no idea if it is working or not. Anyone got any ideas? I'll be going to the GP next week but don't think he's really expert in this area. Hey Shiny, I have been on met for what seems like an age, I was on the pill to combat my acne but got a dvt last year so had to come off it (it was not definately the cause of it which sucks!) I have noticed my skin is getting really bad like when i was a teenager, it makes me really self consious and I am SURE its the met, I have not changed any products etc! Its crap, i sho Continue reading >>
Pcos Acne: Are You Treating The Root Cause Of It?
Are You Treating the Root Cause of PCOS Acne? Feel like you are too old to be suffering from teenage hormonal acne. Youre not alone. A cne affects up to 1 in 3 women with PCOS and was actually what drove me to going to my GP for hormone tests. Fortunately, I never suffered from the painful nodular or cystic acne that I see in some of my patients. However, I was 24 and had decided that I was well past the age for teenage acne. Id been to the GP many times before for my acne, only to be prescribed the birth control pill and a low grade antibiotic. No further investigation was done. It was only when I read that hormones could be causing my acne that I specifically asked for some hormones tests. Low and behold, my testosterone and insulin levels were found to be off the charts. I was diagnosed with PCOS. Unfortunately, even with this newly-diagnosed PCOS, the prescription didnt change. I was still given the birth control pill, an antibiotic and a topical cream. It was also suggested that if I saw no improvements then I could try spironolactone (a powerful anti-androgen) or isotretinoin (marketed as Accutane). The problem with both of these treatments is that they produce a lot of nasty effects in the body. They also dont really solve the root cause of the acne. Although I see PCOS acne improvements from the pill, antibiotics, and spironolactone, a compensatory rebound effect often happens when the drugs are stopped. As I explained in my article about why the pill is not an effective treatment for PCOS , drugs like the pill dont decrease testosterone levels, they just mask its effects. When you stop taking the drugs then your testosterone levels will be just as high as they were before. Conversely, Accutane works by altering gene expression and the side effects are incredib Continue reading >>
Metformin And Pcos: Everything You Need To Know
Metformin is a type of medication used to treat Type 2 Diabetes. Because there is a strong link between diabetes and PCOS, metformin is now commonly proscribed to treat PCOS. But should it be? What is the real relationship between metformin and PCOS? Can Metformin used for PCOS help lessen PCOS symptoms? Metformin used for PCOS: The Science PCOS is an infertility condition that often causes acne, facial hair growth, balding, low sex drive, weight gain, difficulty with weight loss, and mental health disturbances such as depression and anxiety in approximately 15% of women. It is also associated with a myriad of health conditions, spanning from diabetes to hypothyroidism and to heart disease. PCOS is, in short, not a condition to sneeze at. PCOS is a condition of hormone imbalance. With PCOS, male sex hormones such as testosterone and DHEA-S rise relative to the female sex hormones estrogen and progesterone. (…Roughly speaking – it’s complicated. For a full-blown account of the science of PCOS and how it affects you, see here.) Elevated testosterone is very often the primary culprit in causing PCOS. (But not always! For one of my most thorough accounts of other things that can cause PCOS, see here.) Insulin causes testosterone levels to rise because insulin tells the ovaries to produce testosterone. Basically, elevated insulin causes elevated testosterone, which causes PCOS. This is where metformin comes into play. Metformin lowers blood sugar levels below what they would otherwise be after a meal. This is because it intervenes with the liver’s interaction with and production of glucose. Insulin is the body’s way of dealing with blood sugar. If blood sugar is lower, then insulin will be lower, and thus testosterone will be lower. Metformin decreases blood sugar, Continue reading >>
Hair & Acne - Management & Treatment
Excessive facial and/or body hair, scalp hair loss and increased acne due to high levels of androgens can be distressing. There is a range of options to assist you: Cosmetic treatments Creams or gels which reduce pore blocking, oil production by the skin and inflammation can be used to treat acne. Waxing, laser hair removal and electrolysis can be useful measures for reducing hair growth. Of these, laser is the treatment most likely to result in a significant reduction in excess hair growth, but repeated treatments are needed over time, and treatment can be costly. If considering laser hair removal it is important to have this performed by a trained professional who uses the correct machine or technique for your skin type. Some dermatologist practices offer laser hair removal and have particular expertise in treating women with PCOS. They will be able to tell you whether laser hair removal will work on your skin type. Medical treatments Scalp hair loss, excess hair and acne can be can be treated by: Reducing the amount of androgens circulating in the body using: Hormonal contraception Lifestyle changes leading to weight loss which helps to reduce insulin resistance Medications to reduce insulin resistance Reducing the action of the androgens on the body tissues using anti–androgen drugs such as cyproterone acetate, spironolactone, finasteride - these drugs are only used in more severe cases (see below for more detail on each of these) How hormonal contraception works on hair & acne Hormonal contraception in the form of the oral contraceptive pill ('the pill') reduces ovarian production of testosterone and other androgens, in addition to increasing the body's production of sex hormone binding globulin (SHBG). SHBG is a protein which binds tightly to testosterone in the Continue reading >>
Pcos And Acne - What Can Be Done? | Pcos Diet Support
There have been a number of women in the PCOS Diet Support Community who are struggling with Acne, in spite of following a good PCOS diet and taking their supplements. Basically, they are doing everything they can do to manage their testosterone levels naturally. So Ive said that Ill investigate PCOS and Acne and I thought I would share my findings with you as well so we can all benefit. Acne is a skin condition that results in lesions or cysts forming on the skin ( 1 ). It normally forms in areas of the skin where there are the most sebaceous glands (glands located within the hair follicle that secrete an oily substance to lubricate and waterproof the skin) ( 2 ). These areas tend to be the face, back and upper part of the chest. There are a couple of factors at play in the formation of acne ( 3 ): Basically, your pores can get blocked by dead skin cells that dont slough away. Your pores can become infected by a kind of bacteria that causes acne. The sebaceous glands can become over active as a result of high testosterone levels. General inflammation can result in the development of acne ( 4 ). You can see where Im going with this, cant you? One research study has found that 27% of all women with acne also have a diagnosis of Polycystic Ovarian Syndrome ( 5 ). The thing is, we know that PCOS raises our testosterone levels. Its this high testosterone that causes the sebaceous glands to produce too much of the oily sebum, resulting in acne. We also tend to get acne in certain areas that are particularly sensitive to hormones like on our jawline, cheeks, chin and the angles of the neck in particular. Also, instead of getting small bumps on our skin, we get tender knots under the skin that take time to go away ( 6 ). So, we know that Acne and PCOS often go hand in hand an Continue reading >>
Medications - The Ultimate Guide To Hormonal Acne
Hormonal acne can be treated with birth control pills, antiandrogens and other pharmaceuticals. This page covers the pros and cons. This page is part of The Ultimate Guide to Hormonal Acne series. Access the other parts using the table of contents below. Pharmaceutical treatment options include birth control pills, antiandrogens, and insulin lowering drugs (Metformin). This post doesnt cover antibiotics. They arent specific to hormonal acne and taking them for acne is a bad idea . Birth control pills, or combined oral contraceptives, contain a mixture of estrogen and progesterone. They reduce androgen production and increase the production of sex hormone binding globulin, which binds to testosterone and further reduces its bioactivity. All BC pills prescribed for acne include estrogen, which helps to offset the acne-causing effect of androgens. The net effect is a significant reduction in androgen levels and acne. A 2014 paper analyzed 32 studies on the effect of birth control pills on acne. This graph shows the average reduction in acne after 3 months and 6 months of treatment. It takes some time for the effects of birth control pills to kick in. Studies show a reasonable reduction in acne by the end of your 3rd cycle. Keep in mind what while birth control pills reduce acne, the opposite is also true. Many women report a drastic increase in acne after stopping birth control pills. The post-pill acne can be much worse than acne before the pill. Stopping the pills means theres a lot less estrogen to balance androgens, and it may take several months to a year for your hormones to balance. What is the best birth control pill for acne? The short answer is they are all equally effective. 17 studies have compared the effectiveness or 2 or more birth control pills. None of th Continue reading >>
What was your first week on Metformin like? Horrendous? Terrible? Filled with waves of nausea? The sickest you’ve felt in your life? Let’s reminisce for a minute: About a dozen years ago, on December 24, I went to the doctor for a routine physical. Are you envious of my holiday plans? This was in the years before Pinterest, so I was carrying on with regular life activities on Christmas Eve morn rather than bedazzling the cap of an Elf on the Shelf. Anyway, at the Christmas Eve check-up, my physician mentioned that he had read promising things about Metformin being used in women with PCOS. We chatted about Metformin for a bit, talked about other PCOS things, finished up the tests, and then I headed to the pharmacy to pick up the prescription. We had our traditional Christmas Eve dinner of ham, funeral potatoes, salad with asparagus and strawberries; rolls, and other delicious items. Breaking with tradition, this year’s Christmas Eve dinner was followed by Metformin for me. After dinner, we read the Christmas story from the Bible, watched a short film depicting the events in Luke 2, read a new Christmas book, and headed off to bed. That’s when the fun began. In sum: Worst Christmas Ever. Pros: Family, friends, gifts, good music, good food. Cons: Visiting the loo every 15 minutes, constant nausea, wanting to curl up in bed and not wake up for days. Public Service Announcement: Do not start Metformin for the first time on the day prior to a major holiday. My first year on Metformin was pretty rough. I felt like I had morning sickness every single day. I had diarrhea and nausea every morning. When I skipped a few doses hoping for relief, my symptoms would be twice as bad when I re-started. Looking back, I’m actually amazed that I kept taking the medication. If I st Continue reading >>
Does Metformin Help With The Acne Situation?
Does Metformin help with the acne situation? If this is your first visit, be sure tocheck out the FAQ by clicking thelink above. You may have to register before you can post: click the register link above to proceed. To start viewing messages,select the forum that you want to visit from the selection below. Does Metformin help with the acne situation? I've been given a prescrition for Metformin, but I am in a "research phase" to make sure it's the right thing for me before I begin. Has anyone out there had any experience with Metformin? Does it help with acne? ANything you know will be appreciated, Cystas. well actually i had acne before pcos and since starting the met my acne became much worse someone said that it might be that met is trying to normalize my harmones why this could be happening,but i stopped taking it because i was getting big bumps all over my face.However,i must say not everyone has that reaction,some may have it and then it goes away,alot of cysters here said it helped their acne,hopefully you will not have any bad reaction like i did.hth. Hi everyone - My doctor started me on MET to regulate my hormones but also gave me FINACEA (Azaleic acid) cream for my face and it has done wonders. I was noticeing huge bumps and worsening rosacea all over my face but as soon as I started using the cream and met I noticed a difference. I still have some redness but still much better. best of luck!!! I have been on Metformin for 3+ years now, and my face still breaks out very badly. I use Bye Bye Blemish drying lotion (contains 10% sulfur) and that really helps with my acne. Best of luck to you. I think that Met has really helped my acne. I had horrible breakouts before the met, and now after being on met for about 2 1/2 months, it's really improved. Kinda makes u Continue reading >>
Acne And Metformin? | Dailystrength
Hey girls, so ive never had trouble with acne and recently I was told to take Metformin does Metformin cause breakouts? Im fine with having a pimple or two every now and than, but I have like 10 pimples on my face, and there really really red. Ive only been taking Metformin for two weeks now. HELP! :( Metformin does not help with acne. Metformin when taken for PCOS will help you to regulate your blood sugar levels, which is a common problem with women who have PCOS. Metformin is given so that you can start to lose weight and help to reverse your PCOS. To help reduce your acne you need to change/reverse two things that are going on in your body. One you have to adjust your PH level, as this can effect your skin in many way. Two you have to adjust your hormone levels, as this greatly effects your skin (think about kids who have just hit puberty and how there skin tends to be). One way that you can do this is by taking birth control pills. These can help control your hormones and help clear your skin. Although some women with PCOS can have extreme mood swings on birth control, and this does not help if you are trying to conceive. So another way that you can help your skin is with supplements. There are a few on the market that are designed to help with acne and these could work, but the best way would be to take supplements that are designed to help PCOS and in turn acne from PCOS (this is what I am doing). Another way that you can help control your acne is with your diet. Whole foods full of vitamins and minerals will help your skin as well. Avoid processed foods and foods containing added hormones (like milk). Also have a good facial cleansing product that is designed for acne and wash your face twice a day. This will at first make things worse as it cleans out your pou Continue reading >>