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Lmptp Diabetes Reversal

A New Drug May Be Able To Completely Reverse Diabetes

A New Drug May Be Able To Completely Reverse Diabetes

Scientists have used a new drug to reverse diabetes in mice. The drug inhibits the enzyme LMPTP, which contributes to the development of Type 2 diabetes by weakening the body's sensitivity to the hormone. Defining Diabetes In the global community, the number of people with diabetes has been on the rise since 1980, with 422 million people diagnosed by 2014. The U.S. alone has experienced a substantial rise in the incidence of diabetes, with the number of Americans diagnosed increasing from 5.5 million in 1980, to 22 million in 2014—a more than 300 percent increase in less than 40 years. A team of researchers, led by Stephanie Stanford at the University of California, San Diego, is proposing a solution in the form of a single pill that aims to restore insulin sensitivity in diabetic patients. Type 2 diabetes develops when the body’s response to insulin, the hormone responsible for regulating sugar in our blood, weakens. A number of genetic and lifestyle factors will influence whether or not someone develops this type of diabetes in their lifetime. Up until now, drugs were unable to restore the insulin signaling function in diabetic patients — instead, they work by filtering out excess glucose in the blood that comes as a result of the dysfunction. The drug produced by Stanford’s team, on the other hand, hopes to restore function. Restoring Function The drug inhibits an enzyme called low molecular weight protein tyrosine phosphatase (LMPTP), which is suspected to contribute to the reduction in cell sensitivity to insulin. With reduced LMPTP activity, the drug reenables insulin receptors on the surface of cells — particularly those in the liver — which in turn restores the cell’s ability to regulate excess sugar. When the body can once again regulate blood sug Continue reading >>

Diabetes Reversal By Inhibition Of The Low-molecular-weight Tyrosine Phosphatase

Diabetes Reversal By Inhibition Of The Low-molecular-weight Tyrosine Phosphatase

Equine metabolic syndrome (EMS) is a cluster of metabolic disorders, such as obesity, hyperinsulinemia, and hyperleptinemia, as well as insulin resistance (IR). In accordance with the theory linking obesity and IR, excessive accumulation of lipids in insulin-sensitive tissues (lipotoxicity), like liver, alters several cellular functions, including insulin signaling. Therefore, the purpose of the study was to isolate equine hepatic progenitor-like cells (HPCs) and assess whether inhibition of low molecular weight protein tyrosine phosphatase (LMPTP) affects the expression of genes involved in macroautophagy, chaperone-mediated autophagy (CMA), endoplasmic reticulum stress, and mitochondrial dynamics in a palmitate-induced IR model. We demonstrated that LMPTP inhibition significantly enhanced expression of heat shock cognate 70 kDa protein (HSC70), lysosome-associated membrane protein 2 (LAMP2), and parkin (PRKN), all master regulators of selective autophagy. We also observed downregulation of C/EBP homologous protein (CHOP), activating transcription factor 6 (ATF6) and binding immunoglobulin protein encoded by the HSPA gene. Moreover, LMPTP inhibition increased alternative splicing of X-box binding protein 1 (XBP1), suggesting high endonuclease activity of inositol-requiring enzyme 1 alpha (IRE1). Taken together, our data provide convincing evidence that LMPTP inhibition reverses palmitate-induced insulin resistance and lipotoxicity. In conclusion, this study highlights the role of LMPTP in the regulation of CMA, mitophagy, and ER stress, and provides a new in vitro model for studying HPC lipotoxicity in pre-clinical research. Protein tyrosine phosphatases (PTPs), of the receptor and non-receptor classes, are key signaling molecules that play critical roles in cellular Continue reading >>

Diabetes Reversal By Inhibition Of The Low-molecular-weight Tyrosine Phosphatase. | Diabetes Research Centers

Diabetes Reversal By Inhibition Of The Low-molecular-weight Tyrosine Phosphatase. | Diabetes Research Centers

Home Publications Center Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. DIABETES REVERSAL BY INHIBITION OF THE LOW-MOLECULAR-WEIGHT TYROSINE PHOSPHATASE. Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Stanford, Stephanie M., Aleshin Alexander E., Zhang Vida, Ardecky Robert J., Hedrick Michael P., Zou Jiwen, Ganji Santhi R., Bliss Matthew R., Yamamoto Fusayo, Bobkov Andrey A., Kiselar Janna, Liu Yingge, Cadwell Gregory W., Khare Shilpi, Yu Jinghua, Barquilla Antonio, D Y Chung Thomas, Mustelin Tomas, Schenk Simon, Bankston Laurie A., Liddington Robert C., Pinkerton Anthony B., and Bottini Nunzio Animals, Binding Sites, Diabetes Mellitus, Type 2, Drug Evaluation, Preclinical, Enzyme Activation, Enzyme Inhibitors, Gene Deletion, Inhibitory Concentration 50, Mice, Mice, Knockout, Mice, Obese, Models, Biological, Molecular Structure, Molecular Weight, Protein Tyrosine Phosphatases, Small Molecule Libraries, Structure-Activity Relationship Obesity-associated insulin resistance plays a central role in type 2 diabetes. As such, tyrosine phosphatases that dephosphorylate the insulin receptor (IR) are potential therapeutic targets. The low-molecular-weight protein tyrosine phosphatase (LMPTP) is a proposed IR phosphatase, yet its role in insulin signaling in vivo has not been defined. Here we show that global and liver-specific LMPTP deletion protects mice from high-fat diet-induced diabetes without affecting body weight. To examine the role of the catalytic activity of LMPTP, we developed a small-molecule inhibitor with a novel uncompetitive mechanism, a unique binding site at the opening of the catalytic pocket, and an exquisite selectivity over other phosphatases. This inhibitor is orally bioavailable, and Continue reading >>

Can Diabetes Type 2 Be Reversed? Experts Answer

Can Diabetes Type 2 Be Reversed? Experts Answer

It is the burning question most, if not all, people with diabetes type 2 have: can my diabetes be reversed? There is so much information, thousands of articles, home remedies that promise readers the ultimate chance to reverse their diabetes. It sounds too good to be true. However, as with all things on the net and with our health, we must be wary of what we read and what is fed to us as information. Most articles recommend healthy eating and exercising as a way of reversing your diabetes. These are two lifestyle changes that are easy to do if you put your mind into it. Does it work though? If it does, how can you go about doing this or where should you start? We reached out to 28 experts in the field who spilled the beans to us about the reversal of diabetes type 2 and whether it is a myth or a reality. To find out more, please keep reading. 1. Cheryl Orlansky RDN LD CDE Diabetes is a progressive disease however it CAN be reversed. Bariatric surgery results have proven that losing weight in morbidly obese patients with Type 2 Diabetes reverses the disease state. Bariatric surgery outcomes have been studied over 10 years with lower rates of mortality and morbidity. Bypass surgery patients normalize blood sugars within days of the procedure. Other factors may play a role in this disease reversal such as; less food intake, hormonal system changes such as the incretin system, possible malabsorption of nutrients and others are being researched besides weight loss. Diabetes Care; May 2017, 40(5) Many patients with Type 2 diabetes can manage their disease with lifestyle factors very well without medication and are very well controlled. Patients with Type 1 diabetes will always have Type 1 and will always need a sufficient supply of exogenous insulin. At this time, there is no Continue reading >>

Drug To Reverse Type 2 Diabetes Passes Critical Test In Mice

Drug To Reverse Type 2 Diabetes Passes Critical Test In Mice

In a groundbreaking study, researchers found that they were able to effectively reverse type 2 diabetes symptoms in mice by administering a daily oral drug with no adverse side effects. Millions of people worldwide suffer from diabetes, particularly type 2 diabetes—which accounts for nearly 90% of all documented cases. If the medication is successful in humans, it would revolutionize how diabetes is treated. Type 2 diabetes is common in older individuals whose bodies’ do not respond as they should to insulin, the key hormone that regulates blood sugar. Most diabetics opt for insulin injections to control their blood sugar levels, while others rely on restrictive diets to avoid sugar altogether. Though both of these techniques help manage the disease, they cannot cure it. They come with a number of potential of side effects including weight gain and diarrhea. What’s more, dependence on insulin injections may lead to insulin resistance. And if untreated, type 2 diabetes can lead to health problems like kidney disease, nerve damage, and vision problems. The proposed daily pill would restore the body’s sensitivity to insulin and increase the activity of the insulin receptor in the liver. Researchers believe this could introduce a new therapeutic strategy to treating type 2 diabetes and hopefully result in a lessened reliance on insulin injections by people with adult-onset diabetes. Here’s Andy Coghlan, reporting for New Scientist: The drug works by inhibiting an enzyme called low molecular weight protein tyrosine phosphatase (LMPTP), which seems to contribute to cells losing their sensitivity to insulin. By hindering LMPTP, the drug reawakens insulin receptors on the surface of cells – especially in the liver – which normally absorb excess sugar from the bloo Continue reading >>

Drug Reverses Type 2 Diabetes In Mice

Drug Reverses Type 2 Diabetes In Mice

| Written by Jessica Moore Type 2 diabetes is a massive public health challenge. About eight percent of the worlds adult population has it, and the complications are seriousincreased risk of heart attack and stroke, kidney problems, hearing and vision loss and painful nerve damage. Managing blood sugar with diet, routine monitoring and insulin helps prevent these issues, but that takes more time and effort than many patients have. A new experimental drug developed with the help of scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) may spell the end of insulin reliance. A study published in Nature Chemical Biology shows that the compound, which can be given as a pill, restores blood sugar control in a mouse model of diet-induced diabetes. By targeting an enzyme that controls insulin receptor signaling, we found a way to recover cells ability to respond to insulin, says Anthony Pinkerton, Ph.D. , director of medicinal chemistry at SBPs Conrad Prebys Center for Chemical Genomics and a contributor to the research. This could lead to a new treatment approach for type 2 diabetes. The candidate drug blocks an enzyme called low molecular weight protein tyrosine phosphatase (LMPTP), which regulates the insulin receptor. Human genetic studies suggested that individuals with lower LMPTP activity were protected from type 2 diabetes, but the mechanism of protection remained unclear. The new investigation, led by Nunzio Bottini, M.D., Ph.D. , professor at UC San Diego, found that LMPTP has direct actions on the insulin receptor that reduce its signaling activity, making cells less sensitive to insulin. Turning off the LMPTP gene prevented mice from becoming diabetic when they were fed a high-fat diet, so the research team screened compounds to identify LMPTP inhi Continue reading >>

Rcsb Pdb - 5jns: Crystal Structure Of Human Low Molecular Weight Protein Tyrosine Phosphatase (lmptp) Type A Complexed With Phosphate

Rcsb Pdb - 5jns: Crystal Structure Of Human Low Molecular Weight Protein Tyrosine Phosphatase (lmptp) Type A Complexed With Phosphate

141415 Biological Macromolecular Structures Enabling Breakthroughs in Research and Education Funding Organization(s):National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease This is version 1.3 of the entry. See complete history . Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Obesity-associated insulin resistance plays a central role in type 2 diabetes. As such, tyrosine phosphatases that dephosphorylate the insulin receptor (IR) are potential therapeutic targets. The low-molecular-weight protein tyrosine phosphatase (LMP ... Obesity-associated insulin resistance plays a central role in type 2 diabetes. As such, tyrosine phosphatases that dephosphorylate the insulin receptor (IR) are potential therapeutic targets. The low-molecular-weight protein tyrosine phosphatase (LMPTP) is a proposed IR phosphatase, yet its role in insulin signaling in vivo has not been defined. Here we show that global and liver-specific LMPTP deletion protects mice from high-fat diet-induced diabetes without affecting body weight. To examine the role of the catalytic activity of LMPTP, we developed a small-molecule inhibitor with a novel uncompetitive mechanism, a unique binding site at the opening of the catalytic pocket, and an exquisite selectivity over other phosphatases. This inhibitor is orally bioavailable, and it increases liver IR phosphorylation in vivo and reverses high-fat diet-induced diabetes. Our findings suggest that LMPTP is a key promoter of insulin resistance and that LMPTP inhibitors would be beneficial for treating type 2 diabetes. Continue reading >>

Type 2 Diabetes Reversal Is Soon A Possibility Says Research

Type 2 Diabetes Reversal Is Soon A Possibility Says Research

A lifelong of medication and lifestyle changes may be a thing of the past, soon.Researchers from the University of California developed a drug that may do a reversal for Type 2 Diabetes. The diabetes treatment makes use of the inhibition of an enzyme called LMPTP to restore the insulin sensitivity of diabetics. The drug inhibits an enzyme called low molecular weight protein tyrosine phosphatase (LMPTP), which is suspected to contribute to the reduction in cell sensitivity to insulin. With reduced LMPTP activity, the drug reenables insulin receptors on the surface of cells particularly those in the liver which in turn restores the cells ability to regulate excess sugar. When the body can once again regulate blood sugar levels, the condition of Type 2 diabetes is effectively reversed. They studied mice that are fed a high-fat diet, which, due to obesity, developed high blood sugar levels. The rodent is then given a daily dosage of the drug that constrains the enzyme called low molecular weight protein tyrosine phosphatase (LMPTP).With the drug, diabetes reversal can be achieved as the reduction of LMPTP can restore the cells function. Continue reading >>

Small Molecule Inhibitors Of Lmptp: An Obesity Drug Target Bottini, Nunzio Pinkerton, Anthony Bruce La Jolla Institute, La Jolla, Ca, United States

Small Molecule Inhibitors Of Lmptp: An Obesity Drug Target Bottini, Nunzio Pinkerton, Anthony Bruce La Jolla Institute, La Jolla, Ca, United States

Small Molecule Inhibitors of LMPTP: An Obesity Drug Target Obesity-associated insulin resistance plays a central role in the pathogenesis of obesity-associated diabetes. Inhibiting protein tyrosine phosphatases that dephosphorylate and inactivate the insulin receptor is considered a promising approach to decrease insulin resistance in obesity. This grant focuses on a tyrosine phosphatase that directly associates with and dephosphorylates the insulin receptor, called the low molecular weight protein tyrosine phosphatase (LMPTP). LMPTP is highly expressed in insulin-target tissues. Human genetic studies and in vivo data obtained from mice carrying reduced expression of LMPTP suggest that LMPTP promotes diabetes and insulin resistance in obesity. Our goal is to validate LMPTP as a drug target for obesity-associated diabetes by demonstrating that chemical inhibitors of LMPTP ameliorate diabetes in mouse models of obesity. We screened the NIH chemical library for inhibitors of LMPTP, and identified a reasonably potent and selective compound -ML400- that selectively inhibits LMPTP in vitro and is active in cell-based assays of LMPTP activity. We have preliminary evidence that ML400 is active in vivo and ameliorates glucose tolerance in a model of diet-induced obesity. Importantly, inhibition of LMPTP by ML400 occurs through an uncompetitive mechanism of action, suggesting that ML400 targets a novel allosteric site of the phosphatase. The aims of this proposal are to optimize potency and selectivity of ML400 through chemistry (Aim 1), identify the allosteric site targeted by ML400 on LMPTP (Aim 2) and perform in vivo studies with the lead compounds to demonstrate that inhibition of LMPTP improves insulin resistance in obese mice (Aim 3). The proposed hit-to-lead work will yie Continue reading >>

Scientists Create A Pill That Can Stop Type 2 Diabetes In Its Tracks

Scientists Create A Pill That Can Stop Type 2 Diabetes In Its Tracks

Here’s a scary thought about one of America’s leading causes of death: in addition to the 29.1 million people who have diabetes, there are 86 million over the age of twenty who are prediabetic. This reality seems pretty daunting, but new research suggests a cure for type 2 diabetes which accounts for 90 percent of cases nationwide. With type 2 diabetes rising at an alarming rate because of obesity in America, this potential cure is not only timely but necessary.[1,2,3] A Very Brief History of Type 2 Diabetes The earliest record of diabetes that we know of is from the year 1552 BC. Physician Hesy-Ra recorded on 3rd Dynasty Egyptian papyrus that frequent urination is a symptom of the disease. Approximately one century later in the year 500 BC, people recorded descriptions of sugar in the urine and noted its occurrence in obese individuals. Because people believed that diabetic urine had a sweet taste, the Latin word for honey – Mellitus – was added to the term ‘diabetes’. In 1776, English physician Matthew Dobson observed diabetic urine. When he evaporated the urine, he found a brown sugar-like substance which both tasted and looked like brown sugar. Dobson noticed this flavor in diabetic blood as well. Upon further study, he observed that diabetes is fatal five weeks or less for some people while, for others, it’s a chronic condition. Dobson’s observations highlight the first time anyone ever made a distinction between type 1 and type 2 diabetes. American physician Frederick Allen believed that diabetics’ bodies couldn’t use food normally. So, in 1916, he promoted a diet that limited what and how much diabetics could eat. Those admitted to the hospital consumed whiskey mixed with black coffee six times a day, five days a week. After this, they’d fol Continue reading >>

Diabetes Reversal By Inhibition Of The Low Molecular Weight Tyrosine Phosphatase

Diabetes Reversal By Inhibition Of The Low Molecular Weight Tyrosine Phosphatase

Diabetes reversal by inhibition of the low molecular weight tyrosine phosphatase 1Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 2Department of Medicine, University of California, San Diego, La Jolla, CA 1Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 2Department of Medicine, University of California, San Diego, La Jolla, CA 1Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 2Department of Medicine, University of California, San Diego, La Jolla, CA 1Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 2Department of Medicine, University of California, San Diego, La Jolla, CA 3Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 4Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 5Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH 6Institute for Genetic Medicine, University of Southern California, Los Angeles, CA 7Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD 8Department of Orthopaedic Surgery and Department of Pediatrics, University of California, San Diego, La Jolla, CA *Address correspondence to: Nunzio Bottini, M.D., Ph.D., Department of Medicine, University of California, San Diego, 9500, Gilman Drive #0656, La Jolla, CA 92093-0656. Phone: 858-246-2398; [email protected] Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: The publisher's final edited version of this article is available at Continue reading >>

Diabetes Treatment New Developments: Type 2 Diabetes Reversal With New Drug

Diabetes Treatment New Developments: Type 2 Diabetes Reversal With New Drug

Diabetes Treatment New Developments: Type 2 Diabetes Reversal With New Drug Researchers from the University of California developed a drug that may do a reversal for Type 2 Diabetes. The diabetes treatment new developments make use of the inhibition of an enzyme called LMPTP to restore the insulin sensitivity of diabetics. The team led by Stephanie Stanford has offered a solution to Type 2 diabetes patients. In the form of one pill, they ambitiously aim to reverse diabetes, which is something that has never been done before with just medication. They studied mice that are fed a high-fat diet, which, due to obesity, developed high blood sugar levels. The rodent is then given a daily dosage of the drug that constrains the enzyme called low molecular weight protein tyrosine phosphatase (LMPTP). The presence of the LMPTP activity in the diabetes treatment new developments is found to cause the reduction of the sensitivity of the cell to insulin. When the insulin weakens, the body will have a hard time regulating blood sugar level that leads to the development of the Type 2 diabetes. With the drug, diabetes reversal can be achieved as the reduction of LMPTP can restore the cell's function. Moreover, the mice in the study showed no adverse side effects according to Nature.com . As of now, more studies should be made before the drug will be proven to be safe enough to move on to human clinical trials. Stanford, meanwhile, is confident on their drug to become the new therapeutic strategy for Type 2 Diabetes reversal. Over the years, being diagnosed with diabetes has continued to spiral upwards. From 1980 to 2014, over 422 million people are found to be diabetics. In the US alone, there has been a 40 percent increase in diabetes cases from 5.5 million in 1980 to 22 million in 2 Continue reading >>

Is There Cure For Type 2 Yet

Is There Cure For Type 2 Yet

Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community Type 2 diabetes is estimated to affect more than one in sixteen people in the UK. Most of these are diagnosed, but there are still around half a million people who are unaware that the condition is affecting their body. When it is diagnosed, though, what can doctors do to stop it? Medication can regulate blood sugar levels, which counteracts the effects to some extent. But in a breakthrough study, scientists may have found a way to cure type 2 diabetes. According to the Medical Research Council, nearly four million people in the UK have diabetes. And the vast majority around 90 percent are suffering specifically from type 2 diabetes rather than type 1. Heres the difference: Type 1 diabetes: An autoimmune condition where the pancreas is damaged and cannot produce any insulin Type 2 diabetes: A condition which develops largely due to a persons diet and weight. The pancreas becomes unable to produce enough insulin, or the bodys cells fail to react to insulin Some people are genetically predisposed to type 2 diabetes, but it is generally brought on by long-term overweightness increasing in likelihood with age. And much like other weight-related diseases, doctors have so far only been able to recommend lifestyle changes to reduce its impact. While type 2 diabetes is a significant problem in the UK, over in the states its even worse. Around 1 in 11 Americans have type 2 diabetes. And a large amount of them are suffering specifically because of insulin resistance. Touched upon above, this is where the bodys cells cannot take in insulin as normal as opposed to insufficient insulin being produced. This prompted researchers at the University of California to se Continue reading >>

Team Develops Diabetes Drug That Could Completely Reverse The Disease

Team Develops Diabetes Drug That Could Completely Reverse The Disease

Team Develops Diabetes Drug That Could Completely Reverse The Disease A team of researchers at the University of California, San Diego, is developing a pill that restores insulin sensitivity in diabetic patients. Type 2 diabetes develops when the bodys response to insulin a hormone that regulates the amount of glucose in the blood gets weaker. Commercially availabledrugs so far only remove excess glucose in the blood, and have side effects, such as weight gain or diarrhea. The drugs sure can help manage the disease, but cannot reverse or restore the insulin signaling function in diabetic patients. However, the newly developed drug hopes to restore the bodys sensitivity to insulin withoutproducing any adverse side effects. According to the statement released by the team, the drug works by inhibiting an enzyme called low molecular weight protein tyrosine phosphatase (LMPTP), which weakens cell sensitivity to insulin. By reducing LMPTP activity, the drug reawakens insulin receptors on the surface of the cells especially those in the liver. This in turn restores ability to regulate excess sugar and effectively reverses the condition of Type 2 diabetes. Reference: Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nature Chemical Biology, 2017. DOI: 10.1038/nchembio.2344 Continue reading >>

Another Wonder Drug To Reverse Diabetes On The Horizon?

Another Wonder Drug To Reverse Diabetes On The Horizon?

Another Wonder Drug to reverse diabetes on the horizon? Helps to cancel insulin resistance , especially in Fat people Yet another promising drug for Type2 Diabetes on the horizon. The hypothesis is attractive We know that Type 2 diabetes occurs when the pancreas is either not able to produce enough insulin, or the cells of the body simply dont react to insulin. This is known as Insulin Resistance, which may in turn get blood glucose levels to rise.Insulin Resistance is therefore a major cause for Type 2 diabetes, especially in fat people. People with insulin resistance have high blood sugar despite normal or above normal levels of insulin in the blood. Seen in people with excessive body fat (especially in the tummy), insulin resistance is now believed to be mediated through an enzyme: Low Molecular-weight Protein Tyrosine Phosphatase (LMPTP). The hypothesis is that if we can inhibit LMPTP, we will reduce insulin resistance and can possibly cure Type 2 Diabetes at least in fat people. Presently there is no medical treatment available for this condition. The good news is that a new molecule has been developed by the University of California, and this may be the game-changer to this life threatening condition. Mice with insulin resistance were given a daily dose of the drug and this reversed the condition. The type 2 diabetes was effectively cured Scientists had an idea that insulin resistance was caused by a particular enzyme, known as Low molecular weight protein tyrosine phosphatase ( or LMPTP ). This enzyme is found in the liver and it causes the cells to become resistance to the presence of insulin. Hence, the scientists felt that LMPTP inhibitors would be a way to cure type 2 diabetes A study was done where laboratory mice were initially fed a very high fat diet , w Continue reading >>

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