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Lipitor Linked To Diabetes

Atorvastatin Lowers Cholesterol But Raises Blood Sugar

Atorvastatin Lowers Cholesterol But Raises Blood Sugar

As many as 40 million people may be taking statin-type cholesterol-lowering drugs daily in the U.S. Although medications like atorvastatin, lovastatin, simvastatin, pravastatin, and rosuvastatin can bring cholesterol levels down dramatically they can also raise blood glucose levels or make diabetes harder to control as this reader relates: Q. I used to have good blood sugar readings when I was on glyburide. Since I was put on atorvastatin to lower cholesterol I have had trouble with high blood sugar. I read in your Guide to Managing Diabetes that statins can affect blood glucose but the clinical pharmacist at the VA said you are wrong. She insisted that atorvastatin does not affect HbA1c or blood sugar. They now have me on both glipizide and Onglyza and the clinical pharmacist admitted that my HbA1c will not come down. She still insists I have to keep taking these medicines even if they are not working to control my diabetes. A. We are puzzled that your pharmacist was not aware of the official prescribing information for atorvastatin (Lipitor): “Increases in HbA1c and fasting serum glucose levels have been reported with HMG-CoA reductase inhibitors [statins], including LIPITOR.” HbA1c is a measure of how high blood sugar levels have been over the past three months. Clinical trials and other studies have shown that statins can indeed raise blood sugar levels, making it harder to control diabetes. Blood Sugar and Statins: There is general agreement that statin therapy increases the risk of developing diabetes (Current Atherosclerosis Reports, Jan. 2015). Research has shown that there is a 10 to 12 percent increased incidence of new-onset type 2 diabetes in statin takers. The higher the dose and the more potent the statin the greater the risk. Investigators believe tha Continue reading >>

Lipitor

Lipitor

What is Lipitor? Lipitor is a prescription drug manufactured by pharmaceutical giant Pfizer and used to control high cholesterol levels. By lowering cholesterol, the drug aims to prevent dangerous blockages in blood flow and thereby reduce the risk of heart attack and stroke. The U.S. Food and Drug Administration (FDA) approved Lipitor in 1996. The drug’s active ingredient is atorvastatin calcium. This class of medications is generally well-tolerated; however, it has been associated with multiple risks, including: Lipitor belongs to a popular class of cholesterol-lowering drugs called statins, which represent the most widely prescribed class of drugs in the U.S. Lipitor is the most popular of all statins. Patients take statins to lower levels of cholesterol and other fatty substances in the blood that, if left unchecked, can increase the risk for heart attack, stroke and other related health complications. The liver makes most of the cholesterol found in blood. Statins reduce the amount of cholesterol made by the liver and help the liver remove cholesterol that’s already in the blood. How Lipitor Works Cholesterol plays a crucial role in several bodily processes that are essential to our health, but unhealthy levels of cholesterol can lead to buildup (plaque) on the walls of arteries. This can block blood flow to the brain and heart and put people at higher risk for stroke and heart disease. According to the Centers for Disease Control and Prevention, heart disease is the leading cause of death for both men and women in the U.S. Lipitor prevents heart attack and stroke by lowering cholesterol in the blood. It slows the production of cholesterol in the body therefore decreasing the amount of plaque buildup that may block the flow of blood to the heart and brain. Stat Continue reading >>

Statins Linked To Increased Risk Of Type 2 Diabetes

Statins Linked To Increased Risk Of Type 2 Diabetes

Statins linked to increased risk of Type 2 diabetes Studies have shown a modest increase in diabetes risk among patients takingstatinsCredit:Press Association Lowering the "bad" form of cholesterol with statin drugs could increase diabetes risk, a study suggests. Scientists found that people with naturally lower levels of low-density lipoprotein (LDL) cholesterol were less likely to develop heart disease but slightly more vulnerable to Type 2 diabetes. Reducing LDL levels by takingstatinsmay have the same effect, they believe. Lead researcher Dr Michael Holmes, from Oxford University, said: "What we've shown in this study is that the role played by blood lipid levels in disease is a complex one. "While the effect of taking LDL cholesterol-lowering drugs such asstatinsmay slightly increase a person's risk of developing diabetes this effect is greatly outweighed by their benefits in the form of preventing people from suffering from a life-altering heart attack or stroke." The team analysed large data sets of information about genetic make-up to tease apart the possible effects on heart disease and diabetes risk of LDL and so-called "good" cholesterol, high-density lipoprotein (HDL), which is said to be protective. They also looked at the influence of triglyceride blood fats which are associated with heart disease. Cases of heart disease were more likely to occur among people with genetic mutations that increased their levels of LDL or triglycerides, the research showed. But genetic variants that raised either LDL or HDL cholesterol levels, and possibly triglyceride levels, slightly reduced the chances of developing Type 2 diabetes. Continue reading >>

Statin Side Effects: Weigh The Benefits And Risks

Statin Side Effects: Weigh The Benefits And Risks

Statin side effects can be uncomfortable, making it seem like the risks outweigh the benefits of these powerful cholesterol-lowering medications. Doctors often prescribe statins for people with high cholesterol to lower their total cholesterol and reduce their risk of a heart attack or stroke. While statins are highly effective, they have been linked to muscle pain, digestive problems and mental fuzziness in some people and may rarely cause liver damage. Statins include atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Altoprev), pitavastatin (Livalo), pravastatin (Pravachol), rosuvastatin (Crestor) and simvastatin (Zocor). Having too much cholesterol in your blood increases your risk of heart attacks and strokes. Statins block a substance your liver needs to make cholesterol. This causes your liver to remove cholesterol from your blood. If you think you're experiencing side effects from statins, don't just stop taking the pills. Talk to your doctor to see if a change of dosage or even a different type of medication might be helpful. What are statin side effects? Muscle pain and damage One of the most common complaints of people taking statins is muscle pain. You may feel this pain as a soreness, tiredness or weakness in your muscles. The pain can be a mild discomfort, or it can be severe enough to make your daily activities difficult. Oddly enough, most randomized controlled studies of statins indicate that people taking statins develop muscle pain at the same rate as people taking placebo. But up to 29 percent of the people who start taking statins report muscle pain and many discontinue statins because of it. Many of these people do well when they are switched to a different variety of statin. Very rarely, statins can cause life-threatening muscle damage call Continue reading >>

Do Statins Raise Odds For Type 2 Diabetes?

Do Statins Raise Odds For Type 2 Diabetes?

HealthDay Reporter TUESDAY, Oct. 24, 2017 (HealthDay News) -- Cholesterol-lowering medications known as statins may lower your risk of heart disease, but also might boost the odds you'll develop type 2 diabetes, new research suggests. "In a group of people at high risk of type 2 diabetes, statins do seem to increase the risk of developing diabetes by about 30 percent," said the study's lead author, Dr. Jill Crandall. She's a professor of medicine and director of the diabetes clinical trials unit at Albert Einstein College of Medicine in New York City. But, she added, that doesn't mean anyone should give up on statins. "The benefits of statins in terms of cardiovascular risk are so strong and so well established that our recommendation isn't that people should stop taking statins, but people should be monitored for the development of diabetes while on a statin," she explained. At least one other diabetes expert agreed that statins are still beneficial for those at risk of heart trouble. Dr. Daniel Donovan Jr. is professor of medicine and director of clinical research at the Icahn School of Medicine at Mount Sinai Diabetes, Obesity and Metabolism Institute in New York City. "We still need to give statins when LDL (bad) cholesterol isn't under control. A statin intervention can lower the risk of a cardiovascular event by 40 percent, and it's possible the diabetes may have been destined to happen," he said. The new study is an analysis of data collected from another ongoing study. More than 3,200 adults were recruited from 27 diabetes centers across the United States for the study. The research goal was to prevent the progression of type 2 diabetes in people with a high risk of the disease, Crandall said. All of the study participants were overweight or obese. They also all Continue reading >>

Statin Induced Diabetes And Its Clinical Implications

Statin Induced Diabetes And Its Clinical Implications

Go to: INTRODUCTION “Then comes the question, how do drugs, hygiene and animal magnetism heal? It may be affirmed that they do not heal, but only relieve suffering temporarily, exchanging one disease for another”. Statins are one of the most widely prescribed groups of drugs in the world. Although statins have been shown to be beneficial in primary and secondary prevention of cardiovascular disease (CVD) in a number of trials, current reports of increased risk of type 2 diabetes with statin use are of concern. As a result of these reports, on February 28, 2012, the Food and Drug Administration added new safety label changes for the statin class of cholesterol-lowering drugs regarding the potential for increased hemoglobin A1c (HbA1c) and fasting plasma glucose. The present review discusses the evidence available from clinical trials and meta-analyses regarding possible diabetogenic effect of statins, probable mechanisms of this association and how these new observations might change clinical approach to statin use. Continue reading >>

Statins And Diabetes

Statins And Diabetes

Statins, the group of cholesterol-lowering drugs that includes atorvastatin (brand name Lipitor), simvastatin (Zocor), and rosuvastatin (Crestor), have been under increased scrutiny during the last couple of years as studies have linked them to an elevated risk of Type 2 diabetes. Most recently, as David Spero noted in a January blog post here at DiabetesSelfManagement.com, a study of statins in postmenopausal women found a 48% higher risk of diabetes among women who took one of these drugs compared with those who did not. Since this was not a randomized clinical trial, its results are not conclusive. But enough studies have raised concerns that last week, as a New York Times opinion piece notes, the US Food and Drug Administration (FDA) added a warning on diabetes risk to the label of all statins. As the Times piece explains, statins are the most widely prescribed drugs in the world, and they have been in use since the 1980’s. But more powerful statins have achieved widespread use only in the last decade or so, and it appears that these drugs are associated with the greatest diabetes risk. With 20 million Americans taking statins and an estimated risk of developing diabetes from the drugs of 1 in 200, 100,000 people could have diabetes as a result of these drugs. Furthermore, the piece notes, among people without existing heart disease who take statins, the drugs prevent only one heart attack or stroke for every 50 people taking them. Although it is clear from those numbers that statins provide no overwhelming heart-risk reduction or diabetes-risk increase to most people who take them, it is also clear that the heart-related benefit from these drugs is statistically greater than their diabetes-related risk. One particular study, published last year in the Journal of Continue reading >>

Statin Use And Risk Of Diabetes Mellitus

Statin Use And Risk Of Diabetes Mellitus

Go to: STATINS IN DIABETES Statins are used for primary and secondary prevention of cardiovascular diseases. Other benefits due to statins are not mediated by their lipid lowering properties[8] but due to its pleiotropic effects. In conditions like heart failure, cardiac arrhythmias, vascular disease and hypertension the non-lipid lowering pleotropic benefits of statins have been observed[9]. These pleiotropic effects mediated by statins can be due to inhibition of isoprenoid synthesis which in turn inhibits intracellular signaling molecules Rho, Rac and Cdc42. The predominant mechanism that has been postulated is inhibition of Rho and its activation to Rho kinase[10]. Type 2 diabetes is characterized by hyperglycemia, insulin resistance and insulin deficiency. The insulin resistance contributes to the abnormal lipid profile associated with type 2 diabetes[11]. Dyslipidemia contributes to increased cardiovascular events in patients with type 2 diabetes[12]. A linear relationship exists between cholesterol levels and cardiovascular diseases in diabetics even if we ignore the baseline LDL[13]. By predominantly lowering LDL-Cholesterol and due to minor effects on other lipoproteins, statins appear to be beneficial[12]. In Heart Protection Study which was done in diabetics, the decrease in cardiovascular events like first major coronary event, stroke were to the tune of 22% as compared to placebo[14]. It was recommended by American Diabetes Association that statin therapy should be initiated in individuals with diabetes and other cardiovascular risk factors with target LDL cholesterol of 100 mg/dL[15]. Investigators are also of the opinion that statin therapy should depend not on the LDL levels but the cardiovascular complications accompanying diabetes[16]. Other studies wh Continue reading >>

Statins Increase Diabetes Risk By Up To 50% In Older Women

Statins Increase Diabetes Risk By Up To 50% In Older Women

Statins Increase Diabetes Risk by up to 50% in Older Women Statin therapy increases the risk of new-onset diabetes in elderly women by 33%, and the higher the dose, the greater the risk, a new analysis of the observational Australian Longitudinal Study on Women's Health shows. "Clearly, statins have beneficial effects, including a reduction in the risk of cardiovascular events; however, the dose-response effect we observed suggests that it may be wise to avoid using higher doses of statins in older women," lead author Mark Jones, MD, senior lecturer, school of public health, the University of Queensland, Brisbane, Queensland, told Medscape Medical News in an email. "GPs and their elderly female patients should be aware of the risks," Dr Jones added in a University of Queensland statement, noting that those elderly women taking statins "should be carefully and regularly monitored for increased blood glucose to ensure early detection and management of diabetes." And, he and his colleagues suggest, it may be the case that statins could be stopped altogether in some elderly women. Women Take Statins on Average, for 6.5 Years The new analysis included 8372 Australian women aged between 76 and 82 years at baseline who were followed for 10 years; it is published in the March issue of Drugs and Aging. Dr Jones and colleagues note that the majority of participants in statin trials have been males and that females, especially elderly ones, have been underrepresented. "Our group has expertise and experience in women's health, including being involved with the Australian Longitudinal Study on Women's Health for the past 20 years, and we focused on the older cohort of women [in this study] because we thought this is a population that has generally not been included in clinical tria Continue reading >>

Statins Linked To Raised Risk Of Type 2 Diabetes

Statins Linked To Raised Risk Of Type 2 Diabetes

HealthDay Reporter WEDNESDAY, March 4, 2015 (HealthDay News) -- Cholesterol-lowering statin drugs may significantly increase a person's risk of developing type 2 diabetes, a new study from Finland suggests. Researchers found that statins were associated with an almost 50 percent higher risk of developing type 2 diabetes, even after adjusting for other factors. Statins appear to increase the risk of type 2 diabetes in several ways, the researchers said. One is that the drugs can increase a person's insulin resistance, and the other is that the cholesterol-lowering drugs seem to impair the ability of the pancreas to secrete insulin, according to the report. Commenting on the study, Dr. Ronald Goldberg, director of the Lipid Disorder Clinic and associate director of the Diabetes Research Institute at the University of Miami, said the researchers "show evidence that statins increased insulin resistance, and that the people who developed diabetes appeared to have less ability to respond to the insulin resistance by making more insulin." The study authors noted, however, that their research only found an association between statin use and diabetes risk. And since the study was limited to white men, it's not clear if the findings would apply to women or other racial groups. More than 29 million people in the United States have diabetes, according to the American Diabetes Association (ADA). Type 2 diabetes occurs when the body becomes resistant to insulin, a hormone needed to process the sugars found in foods. To compensate, the body produces more insulin. Excess weight and a sedentary lifestyle are two important risk factors for type 2 diabetes, according to the ADA. Prior studies have indicated that statins may increase a person's risk of diabetes, the authors said in backgro Continue reading >>

Does Lipitor Increase My Risk For Diabetes?

Does Lipitor Increase My Risk For Diabetes?

Lipitor (atorvastatin) is intended to treat and lower high cholesterol levels. By doing so, it can reduce a person’s risk of heart attack and stroke. Lipitor and other statins actually block low-density lipoprotein (LDL) cholesterol production in the liver. LDL is known as the “bad” type of cholesterol. People with high levels of LDL are at risk for stroke, heart attack, and other cardiovascular conditions. Statin medications also help your body reabsorb some of the LDL that is already present in your arteries. Millions of Americans rely on statin medications like Lipitor to regulate and treat high cholesterol. Statins: Uses, Side Effects, and More » As with any medication, Lipitor may cause side effects. Studies have shown a possible connection between Lipitor and serious side effects, such as type 2 diabetes. This risk for diabetes may be especially strong in women and postmenopausal women, according to a 2012 study in the Archives of Internal Medicine. Other side effects of Lipitor include: arthritis back pain chest pain fatigue loss of appetite infection insomnia diarrhea rash stomach pain nausea urinary tract infection painful urination difficulty urinating swelling in feet and ankles potential muscle damage memory loss or confusion increased blood sugar levels In 1996, the U.S. Food and Drug Administration (FDA) approved Lipitor for the purpose of lowering cholesterol. Following its release, scientists found that more people who are on statin therapy are diagnosed with type 2 diabetes compared to people who are not on statin therapy. In 2012, the FDA updated their guidelines for the popular statin drug class. They added to the warning information that a “small increased risk” of high blood sugar levels and type 2 diabetes has been reported in individual Continue reading >>

If Statins Cause Diabetes, Why Should All Diabetics Take A Statin?

If Statins Cause Diabetes, Why Should All Diabetics Take A Statin?

The guidelines from the American Heart Association and the American College of Cardiology are crystal clear. People with diabetes (both type-1 and type-2) should all be on a statin-type cholesterol-lowering medicine! There are no exceptions to this recommendation. Any physician who strays from the path of prescribing a statin to his or her diabetic patients will presumably be practicing bad medicine. What makes this guideline so intriguing is the growing body of evidence suggesting that statins cause diabetes in a substantial number of people. So, the very drug that induces elevated blood sugars is required to treat the cardiovascular risks associated with the development of drug-induced type-2 diabetes. Does this seem as odd to you as it does to us? Do Statins Cause Diabetes? Do you doubt that statins cause* diabetes? Here is just the latest research on this connection (Dormuth et al, BMJ, online, May 29, 2014). Researchers analyzed data on nearly 140,000 patients in Canada, the UK and the U.S. All the individuals had been hospitalized either because of a heart attack, stent placement or some other serious cardiovascular procedure. Some were given low-potency statins while others were placed on high-potency statins such as rosuvastatin (Crestor) at a dose of 10 mg or greater, atorvastatin (Lipitor) at a dose of 20 mg or higher or simvastatin (Zocor) at a dose of 40 mg or higher. None of the people in the analysis had been diagnosed or treated for diabetes prior to being placed on a statin. Within two years of starting on the medicine 3,629 patients were diagnosed with type-2 diabetes. Those given high-potency statins were 15% more likely to end up with blood sugar elevations compared to patients prescribed lower-potency statins or lower doses. The lead author, Colin Do Continue reading >>

Statin Use Linked To Increased Risk Of Type 2 Diabetes

Statin Use Linked To Increased Risk Of Type 2 Diabetes

Statin use is linked to an increased risk of type 2 diabetes among high-risk individuals, a new study reports. Statins are cholesterol-lowering drugs prescribed to reduce cardiovascular risks, but a variety of studies have shown the drugs have an association with type 2 diabetes development. These new findings were from a long-term US study of 3,234 patients at high risk of type 2 diabetes, all of whom had elevated BMIs and blood sugar levels. Participants took part in the US Diabetes Prevention Program Outcomes Study (DPPOS) and were randomised to receive different interventions to prevent type 2 diabetes. These included an intensive lifestyle programme, metformin treatment or a placebo drug. They were then followed for an average of 10 years. Fewer than four per cent of participants took statins at the study's start, but this figure increased to around a third of participants after 10 years. Moreover, statin use was associated with heightened type 2 diabetes risk irrespective of which treatment group a patient belonged to. Overall, statin use was associated with a 36 per cent increased risk of type 2 diabetes development compared to those who did not take the drugs. No link was observed between statin potency in diabetes risk, nor in regard to LDL cholesterol. While this was an observational study and no causal link between statin use and diabetes risk can be made, the researchers point to evidence suggesting that statins can impair insulin production. This, they believe, could help explain the diabetes risk. They added, however, that the potential increased risk of diabetes should always be weighed carefully against any benefits of statins, which include reduced risk of a heart attack and stroke in certain groups of people. The findings appear online in the online jo Continue reading >>

Cholesterol-lowering Drugs May Be Linked To Diabetes

Cholesterol-lowering Drugs May Be Linked To Diabetes

You may have concerns about taking a cholesterol-lowering statin drug, such as atorvastatin (Lipitor and generic), rosuvastatin (Crestor), and simvastatin (Zocor and generic), after a recent study linked those drugs to an increased risk of type 2 diabetes. But Consumer Reports Best Buy Drugs experts say the heart-protective benefit of statins usually outweighs the risk of diabetes, so don’t skip a statin if you need one to lower your cholesterol. Diabetes isn’t a new side effect of statins. The Food and Drug Administration added it to the label of all statins in 2012 based on a review of studies that found a slightly elevated risk. For example, one study that reviewed 13 randomized, controlled clinical trials of statins found that 4.9 percent of people who took one of the drugs for 4 years developed diabetes compared with 4.5 percent of those who didn’t take a statin. Lower Cholesterol vs. Higher Blood Glucose The new study, published in the Journal of General Internal Medicine, raises questions about whether the diabetes risk is higher than previously thought. Researchers looked at medical data of nearly 7,000 men and women with an average age of 53. About 31 percent of those who took a statin for an average of 5.5 years developed diabetes compared with 19 percent of those who didn’t. But since the study was not a randomized, controlled study—the gold standard for determining whether a drug causes a particular side effect—it’s not known for sure that the increase in diabetes was entirely due to statins. The study participants might have had other factors that contributed to the development of diabetes. "All we can say," says Ishak Mansi, M.D., an internist at the Veteran's Hospital in North Texas and co-author of the study, "[is] that in the healthy popul Continue reading >>

Statins Increase The Risk Of Developing Diabetes In At-risk People

Statins Increase The Risk Of Developing Diabetes In At-risk People

Among susceptible individuals, statins — which are a common cholesterol-lowering medication — could increase the risk of type 2 diabetes by 30 percent. These new findings are sure to reignite debate. Statins lower cholesterol by reducing its production in the liver. They do this by blocking an enzyme called hydroxy-methyl-glutaryl-coenzyme A reductase, which is involved in its manufacture. Statins are one of the most widely prescribed types of drug in the United States. Between 2011 and 2012, over a quarter of U.S. adults over the age of 40 were taking cholesterol-lowering medication. The vast majority of these drugs were statins. Alongside their cholesterol-lowering ability, statins also have positive effects on inflammation and oxidative stress. Taken together, it would be unsurprising if statins helped to reduce the risk of developing diabetes. But the reverse may well be true. Evidence is mounting that long-term statin use could increase the risk of type 2 diabetes. The first study to mention this potential effect was published in 2008. Between then and now, many meta-analyses have been carried out. Some have added evidence supporting a link between statin use and type 2 diabetes, while others have brought such a link into question. Therefore, a definitive answer is yet to be found. Reopening the statin-diabetes debate Many previous studies that pointed out a link did not specifically set out to investigate diabetes and statins; their prime focus was on cardiovascular events. Because the number of diabetes cases within the experimental groups was low, it was difficult to get a good understanding of the associated risks. So, to take a fresh look at this interaction, researchers from the Albert Einstein College of Medicine in New York City, NY, decided to focus th Continue reading >>

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