Levemir 30 Units

Levemir (insulin Detemir) Dosing, Indications, Interactions, Adverse Effects, And More

Once daily dosage: Administer SC with evening meal or at bedtime Twice daily dosage: Administer SC with morning meal and either with evening meal, at bedtime, or 12 hr after the morning dose Type 1 diabetes: Approximately one third of the total daily insulin requirements SC; rapid-acting or short-acting, premeal insulin should be used to satisfy the remainder of the daily insulin requirements; usual daily maintenance range is 0.5-1 unit/kg/day in divided doses; nonobese may require 0.4-0.6 unit/kg/day; obese may require 0.6-1.2 units/kg/day Type 2 diabetes inadequately controlled on oral medication: 10 units/day SC (or 0.1-0.2 unit/kg/day) in evening or divided q12hr Type 2 diabetes inadequately controlled on GLP-1 receptor agonist: 10 units/day SC given once daily in evening Subsequently adjust dose based on blood glucose measurements If converting from insulin glargine: Change can be accomplished on a unit-to-unit basis If converting from NPH insulin: Change can be accomplished on a unit-to-unit basis; however, some patients with type 2 diabetes may require more insulin detemir than NPH insulin Closely monitor blood glucose during transition and in the initial weeks thereafter; concurrent rapid-acting or short-acting insulins or other concomitant antidiabetic treatment may require dose adjustment Dosage of human insulin, which is always expressed in USP units, must be based on the results of blood and urine glucose tests and must be carefully individualized to optimal effect Dose adjustments should be based on regular blood glucose testing Adjust to achieve appropriate glucose control Look for consistent pattern in blood sugars for >3 days Same time each day: Compare blood glucose level with previous levels that occurred at that time of day For each time of day: Calc Continue reading >>

Levemir

LEVEMIR® (insulin detemir [rDNA origin]) Injection DESCRIPTION LEVEMIR® (insulin detemir [rDNA origin] injection) is a sterile solution of insulin detemir for use as a subcutaneous injection. Insulin detemir is a long-acting (up to 24-hour duration of action) recombinant human insulin analog. LEVEMIR® is produced by a process that includes expression of recombinant DNA in Saccharomyces cerevisiae followed by chemical modification. Insulin detemir differs from human insulin in that the amino acid threonine in position B30 has been omitted, and a C14 fatty acid chain has been attached to the amino acid B29. Insulin detemir has a molecular formula of C267H402O76N64S6 and a molecular weight of 5916.9. It has the following structure: Figure 1: Structural Formula of insulin detemir LEVEMIR® is a clear, colorless, aqueous, neutral sterile solution. Each milliliter of LEVEMIR® contains 100 units (14.2 mg/mL) insulin detemir, 65.4 mcg zinc, 2.06 mg m-cresol, 16.0 mg glycerol, 1.80 mg phenol, 0.89 mg disodium phosphate dihydrate, 1.17 mg sodium chloride, and water for injection. Hydrochloric acid and/or sodium hydroxide may be added to adjust pH. LEVEMIR® has a pH of approximately 7.4. Continue reading >>

Levemir® (insulin Detemir [rdna Origin] Injection) Indications And Usage

Levemir® is contraindicated in patients with hypersensitivity to Levemir® or any of its excipients. Never Share a Levemir® FlexTouch® Between Patients, even if the needle is changed. Sharing poses a risk for transmission of blood-borne pathogens. Dosage adjustment and monitoring: Monitor blood glucose in all patients treated with insulin. Insulin regimens should be modified cautiously and only under medical supervision. Changes in insulin strength, manufacturer, type, or method of administration may result in the need for a change in insulin dose or an adjustment of concomitant anti-diabetic treatment. Administration: Do not dilute or mix with any other insulin or solution. Do not administer subcutaneously via an insulin pump, intramuscularly, or intravenously because severe hypoglycemia can occur. Levemir® (insulin detemir [rDNA origin] injection) is indicated to improve glycemic control in adults and children with diabetes mellitus. Levemir® is not recommended for the treatment of diabetic ketoacidosis. Intravenous rapid-acting or short-acting insulin is the preferred treatment for this condition. Levemir® is contraindicated in patients with hypersensitivity to Levemir® or any of its excipients. Never Share a Levemir® FlexTouch® Between Patients, even if the needle is changed. Sharing poses a risk for transmission of blood-borne pathogens. Dosage adjustment and monitoring: Monitor blood glucose in all patients treated with insulin. Insulin regimens should be modified cautiously and only under medical supervision. Changes in insulin strength, manufacturer, type, or method of administration may result in the need for a change in the insulin dose or an adjustment of concomitant anti-diabetic treatment. Administration: Do not dilute or mix with any other insulin Continue reading >>

Getting High Blood Sugar Levels Under Control

Getting high blood sugar levels under control Getting high blood sugar levels under control A 70-year-old man with a history of type 2 diabetes takes insulin glargine (Lantus) 100 units every morning (he is afraid of developing hypoglycemia at night) and insulin aspart (Novolog) 20 units with each meal. However his blood sugar is still around 250 mg/dL. Can the Lantus dose be increased, and if so, to what? Or should the patient be switched to insulin detemir (Levemir) twice daily? Can the dose of Levemir be greater than 100 units? What else would you suggest for this patient? If your patient's blood sugars are in the 250 range all day, he likely needs more insulin. Patients with type 2 diabetes will routinely need 1-2+ units/kg body weight per day. If he is requiring more than this, one should look for factors that might increase insulin resistance (infection, Cushing syndrome, etc.), noncompliance, or incorrect administration. (I have discovered that some patients who were supposed to be taking multiple shots of insulin per day were injecting air and not insulin!). There is no maximum dose of glargine per se, although at doses >100 units, I usually prescribe this agent b.i.d. In addition, we are finding that in some patients, Lantus seems to last only 12-18 hours, so that splitting the dose to 80 units in the morning and 30 units at bedtime would likely improve his morning/fasting blood sugars. Using insulin detemir b.i.d. at this dose would also suffice. Most patients on stable insulin regimens are taking approximately 50% as basal (glargine in this case) and 50% as bolus (mealtime aspart), so this patient likely needs an increase in his prandial doses. If, despite dosing adjustments that put him at 250-300+ units/day of insulin U-100, he is still not at goal, many d Continue reading >>

Selected Important Safety Information

Tresiba® is contraindicated during episodes of hypoglycemia and in patients with hypersensitivity to Tresiba® or one of its excipients Never Share a Tresiba® FlexTouch® Pen Between Patients, even if the needle is changed. Sharing poses a risk for transmission of blood-borne pathogens Monitor blood glucose in all patients treated with insulin. Changes in insulin may affect glycemic control. These changes should be made cautiously and under medical supervision. Adjustments in concomitant oral anti-diabetic treatment may be needed Hypoglycemia is the most common adverse reaction of insulin, including Tresiba®, and may be life-threatening Tresiba® (insulin degludec injection) is indicated to improve glycemic control in patients 1 year of age and older with diabetes mellitus. Tresiba® is not recommended for treating diabetic ketoacidosis or for pediatric patients requiring less than 5 units of Tresiba®. Tresiba® is contraindicated during episodes of hypoglycemia and in patients with hypersensitivity to Tresiba® or one of its excipients Never Share a Tresiba® FlexTouch® Pen Between Patients, even if the needle is changed. Sharing poses a risk for transmission of blood-borne pathogens Monitor blood glucose in all patients treated with insulin. Changes in insulin may affect glycemic control. These changes should be made cautiously and under medical supervision. Adjustments in concomitant oral anti-diabetic treatment may be needed Hypoglycemia is the most common adverse reaction of insulin, including Tresiba®, and may be life-threatening. Increase monitoring with changes to: insulin dose, co-administered glucose lowering medications, meal pattern, physical activity; and in patients with hypoglycemia unawareness or renal or hepatic impairment Accidental mix-ups betwe Continue reading >>

Levemir Vs. Lantus: Similarities And Differences

Levemir and Lantus are both long-acting injectable insulins that can be used for long-term management of diabetes. Insulin is a hormone that is naturally produced in the body by the pancreas. It helps convert the glucose (sugar) in your bloodstream into energy. This energy is then distributed to cells throughout your body. With diabetes, your pancreas produces little or no insulin or your body is unable to use the insulin correctly. Without insulin, your body can’t use the sugars in your blood and can become starved for energy. The excess sugar in your blood can also damage different parts of your body, including your blood vessels and kidneys. Everyone with type 1 diabetes and many people with type 2 diabetes must use insulin to maintain healthy blood sugar levels. Levemir is a solution of insulin detemir, and Lantus is a solution of insulin glargine. Both are basal insulin formulas. That means that they work slowly to lower your blood sugar levels. They’re both absorbed into your body over a 24-hour period. They keep blood sugar levels lowered for longer than short-acting insulins do. Although the formulations are slightly different, Levemir and Lantus are very similar drugs. There are only a few differences between them. Children and adults can use both Levemir and Lantus. Specifically, Levemir can be used by people who are 2 years or older. Lantus can be used by people who are 6 years or older. Levemir or Lantus can help with daily management of diabetes. However, you may still need to use short-acting insulin to treat spikes in your blood sugar levels and diabetic ketoacidosis (a dangerous buildup of acids in your blood). Learn more: All about diabetic ketoacidosis » Administration Both Levemir and Lantus are given through injection in the same way. You can gi Continue reading >>

Product Important Safety Information

Selected Important Safety Information WARNING: RISK OF THYROID C-CELL TUMORS Liraglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures in both genders of rats and mice. It is unknown whether Victoza® causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans, as the human relevance of liraglutide-induced rodent thyroid C-cell tumors has not been determined. Victoza® is contraindicated in patients with a personal or family history of MTC and in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Counsel patients regarding the potential risk for MTC with the use of Victoza® and inform them of symptoms of thyroid tumors (eg, a mass in the neck, dysphagia, dyspnea, persistent hoarseness). Routine monitoring of serum calcitonin or using thyroid ultrasound is of uncertain value for early detection of MTC in patients treated with Victoza®. Selected Important Safety Information Tresiba® is contraindicated during episodes of hypoglycemia and in patients with hypersensitivity to Tresiba® or one of its excipients Levemir® is contraindicated in patients with hypersensitivity to Levemir® or any of its excipients NovoLog® and NovoLog® Mix 70/30 are contraindicated during episodes of hypoglycemia and in patients hypersensitive to insulin aspart or any of the excipients Warnings and Precautions Never Share a Tresiba® FlexTouch®; Levemir® FlexTouch®, NovoLog® FlexPen, NovoLog®FlexTouch®, PenFill® Cartridge, or PenFill® Cartridge Device; or NovoLog®Mix 70/30 FlexPen® Between Patients, even if the needle is changed. Patients using vials must never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens Hypoglyc Continue reading >>

Question About My Levemir Dosings

The doc changed my dose from 30 units at bedtime to 15 units at bedtime and 15 units after breakfast. Just was wondering on those who split their doses up like this, if it seemed to be better than taking it all at once at bedtime? He changed it because my sugars seemed to be spiking around lunch time. I am also taking 25 units of Novolog before meals. I am going to try it for a week, but I worry about my morning fasting sugars going up. They have been normal since taking all 30 units of the Levemir at night. Will my fasting sugars go up much? Thanks in advance for your advice! D.D. Family T1 since 1977 - using Novolog in an Animas pump. The doc changed my dose from 30 units at bedtime to 15 units at bedtime and 15 units after breakfast. Just was wondering on those who split their doses up like this, if it seemed to be better than taking it all at once at bedtime? He changed it because my sugars seemed to be spiking around lunch time. I am also taking 25 units of Novolog before meals. I am going to try it for a week, but I worry about my morning fasting sugars going up. They have been normal since taking all 30 units of the Levemir at night. Will my fasting sugars go up much? Thanks in advance for your advice! If your morning numbers go up, just increase the Levemir again. Use as much Levemir at night as you need for good morning numbers, and as much Levemir as you need in the morning to have good numbers later in the day. It is easier to get the morning numbers right first. So when your morning numbers are good, don't change the evening Levemir. You may need your existing dose as well as some Levemir in the morning. Continue reading >>

Math Calculations With Diabetes Insulin

www.TakeRx.com Calculate the total quantity and the total days supply for the following Rx: Humalog 75/25 30U sq am/pm #3 vials ------------------------------------------------------------ The doctor has prescribed 3 vials of Humalog Mix 75/25 Each vial of Humalog Mix has 10 mL of insulin 1 vial = 10 mL and then 3 vials = 30 mL So, the total quantity to be dispensed will be 30 mL The sig says: inject 30 units subcutaneously in the morning and in the evening In other words, the patient will inject 60 units per day. Now, we need to convert 60 units into mL We know that the ratio is 1mL/100U x / 60U = 1mL / 100U x = (60 * 1) / 100 x = 0.6 mL So, the patient will inject 0.6 mL per day. Now, the total days supply will be 30mL divided by 0.6mL which is 50 days. Calculate the total quantity and the total days supply for the following Rx: Levemir insulin qty: 1 inj 60 units sc qd ------------------------------------------------------------ The doctor has prescribed the brand-name drug Levemir insulin. The doctor wants the pharmacist to dispense one vial. One vial has 10 mL of insulin. So, the total quantity to be dispensed is 10mL The sig says: inject 60 units subcutaneously every day The ratio for the insulin is 1 mL per 100 units. We need to convert 60 units into mL x / 60 U = 1 mL / 100 U x = (60U * 1mL) / 100U x = 60 / 100 x = 0.6 mL In turn, the patient will use 0.6 mL per day. Now, the total days supply will be 10 mL divided by 0.6 mL which is 16 days. Calculate the total quantity and the total days supply for the following Rx: Levemir flexpen #15 mL 70 U qd ------------------------------------------------------------ The doctor has prescribed Levemir flexpen injection (U-100) 5X3mL prefilled pens. The package has 5 pens and each pen has 3mL and, thus, we can say the pack Continue reading >>

Levemir Flextouch And Vial | Levemir (insulin Detemir [rdna Origin] Injection)

Levemir FlexTouch, the latestin prefilled pen technology from Novo Nordisk Low-injection force push button.A built-in spring mechanism requires low force to inject all doses. When your dose is delivered, youshould hear or feel a clicka Accurate dosing.Turn the dose selector to select the number of units you need to inject, from 1-80 units. A large and clear dose display shows the units you have selected Thinnest needle available.The 32G Tip needle is the thinnest needle made by Novo Nordisk,b a leader in diabetes care for more than 90 years More insulin than a vial.One box of LevemirFlexTouch contains 5 disposable pens, each prefilled with 300 units of Levemir for a total of 1500 units of Levemirinsulin. Youll get 50% more insulin than you get from a vial (1000 units) Insurance coverage.Levemir FlexTouch is covered by most health insurance and Medicare plans nationwide aAfter dose counter has returned to 0, keep needle in skin for 6 seconds before the needle is removed. If you do not, you may not have received your full dose and you should check your blood sugar more often because you may need more insulin. You may or may not hear an audible click at end of dose. bNeedles are sold separately and may require a prescription in some states. Needles and LevemirFlexTouchmust not be shared. If you prefer to take your insulin with a vial and syringe, or if you need to receive your insulin in a vial for insurance reasons, you can still get Levemir. Unopened Levemirshould be kept in the refrigerator at a temperature range between 36 and 46F (2 and 8C) Keep unopened Levemir in the carton to protect from light Unopened Levemir can stay in the refrigerator until expiration. See the expiration date on the box Keep at room temperature, below 86F (30C), and not refrigerated for up to Continue reading >>

Making Insulin Work

As you all probably experience in your own lives, it often seems like things come in waves. And this past week the wave I have been experiencing has been full of worried emails from people who report that they or a loved one have recently started insulin but that it isn't working. In every case, the insulin is a slow acting insulin, Lantus or Levemir, and there's a good reason why the insulin isn't working. It is because the dose being used is far too low to have an impact on an insulin resistant Type 2. When doctors intially start a person with Type 2 diabetes on a slow acting insulin they start out with a very low dose, usually 10 units. This is prudent. One in ten "Type 2s" is not really a Type 2. Most of these misdiagnosed "type 2s" turn out to be people in the early stages of LADA, Latent Autoimmune Diabetes of Adults, which is a a slow onset form of autoimmune diabetes. People with LADA usually have normal or near normal insulin sensitivity and for them an injection of ten units is a LOT of insulin. One or two percent of people diagnosed as Type 2 turn out to be people like me who have other oddball genetic forms of diabetes that also make them very sensitive to insulin. So starting everyone out at a low dose of insulin makes sense since this way the misdiagnosed people who turn out to have normal insulin sensitivity will avoid hypos caused by too much insulin. But once it is clear that a person really is a Type 2--since they see no response at all to a dose of 10 units of insulin, the doctor is supposed to raise the dose until it gets to the level where it will drop the fasting blood sugars. But many doctors do not explain this to their patients and quite a few raise the dose so slowly that it does seem to the poor patient that insulin won't solve their problems. Continue reading >>

Hit Me With Your Best Shot: Updates In Insulin Therapy

C A T H Y E D I C K , P H A R M D , C D E A P R I L 9 , 2 0 1 7 Pharmacist Learning Objectives ï‚— List the onset, peak and duration of action for the various insulin preparations ï‚— Determine which insulin to use and how to adjust doses based on blood glucose values from a given patient ï‚— Assess where the newest insulin products fit into diabetes management Pharmacy Technician Learning Objectives ï‚— List the onset, peak and duration of action for the various insulin preparations ï‚— Describe the newest insulin products ï‚— Describe how blood glucose values are used to make adjustments to insulin regimens Insulin Basics ï‚— When is insulin indicated? ï‚¡ Type 1 = ALWAYS ï‚¡ Type 2 = ïƒ· High baseline A1c ïƒ· Poorly controlled on 3 oral/non-insulin medications ïƒ· Contraindications to non-insulin medications ïƒ· Pregnant women ïƒ· Hospitalized patients Review Question ï‚— Which of the following appropriately orders the insulins from shortest acting to longest acting? A. NPH, Lantus, Humalog B. Humulin R, Novolog, Levemir C. Tresiba, NPH, Levemir D. Novolog, NPH, Lantus Insulin Basics Types Examples Rapid-acting Aspart (Novolog) Lispro (Humalog) Glulisine (Apidra) Short-acting Regular (Humulin R, Novolin R) Intermediate- acting NPH (Humulin N, Novolin N) Long-acting Glargine (Lantus, Basaglar, Toujeo) Detemir (Levemir) Ultra long-acting Degludec (Tresiba) 4/4/2017 2 Insulin Basics Onset Peak Duration Rapid-acting 15-30 min 30 min to 2.5 hours 3 to 6.5 hours Short-acting 30 min to 1 hour 2 to 3 hours 8 hours Intermediate- acting 1 to 2 hours 4 to 10 hours 16 to 24 hours Long-acting Glargine 1 hour Relatively flat 20 to 24 hours Detemir 1 to 2 hours Relatively flat 12 to 24 hours (dose dependent) Ultra long- Continue reading >>

Levemir Overview

Levemir is a prescription medication used to treat type 1 and type 2 diabetes. Levemir, a long-acting form of insulin, works by replacing the insulin that is normally produced by the body and by helping the body to use sugar for energy. It also stops the liver from producing more sugar. This medication comes in an injectable form and is typically injected under the skin once or twice daily. Common side effects include redness and skin thickening at the injection site, weight gain, and constipation. Levemir is a man-made long-acting insulin that is used to control high blood sugar in adults and children with type 1 and type 2 diabetes. This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information. Levemir may cause serious side effects. See "Drug Precautions" section. Common side effects of Levemir include: Low blood sugar (hypoglycemia) Reactions at the injection site (local allergic reaction). You may get redness, swelling, and itching at the injection site. If you keep having skin reactions or they are serious, talk to your doctor. Weight gain. This can occur with any insulin therapy. Talk to your doctor about how Levemir can affect your weight. Tell your doctor if you have any side effect that bothers you or does not go away. These are not all of the possible side effects from Levemir. Ask your doctor or pharmacist for more information. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalap Continue reading >>

New Here. What Is The Maximum Amount Of Levemir And Novolog That You Take?

New here. What is the maximum amount of Levemir and Novolog that you take? Registration is fast, simple and absolutely free so please,join our community todayto contribute and support the site. This topic is now archived and is closed to further replies. New here. What is the maximum amount of Levemir and Novolog that you take? I have been put on injectables for about a year but my A1C is getting worse. At first I was put on low amounts of Levemir and Novolog but nothing worked and am now at 40 units of Levimir in the morning and 50 units at night. I also am taking 25 units of Novolog at dinner and sometimes 10 to 15 at lunch. My A1c is still over 8 and I test at 170 to 200 in the morning. My GP say that I should jut slowly increase my meds. My endo says not to do this. I am in the process of getting a treadmill so I can do at least 30 minute a day. How high can I go with these meds. I am so confused and am so upset that I have been at this for a year and my A1c has increased and I believe I have gained about 7 pounds over the year from the insulin. Any thoughts would be greatly appreciated. Should I go on a pump and if I do so would that record the amount of insulin I need. My endo has me afraid to increase my insulin but I feel sick from my raised blood sugars. Thank you for any thoughts you may have. I am so grateful to join this forum Hi Christine, this is a good place for you to get help. I take 140 units of Lantus, split morning and night, and anywhere from 10 to 30 units of Novolog per meal. I still have some days I cannot keep my numbers low enough. I did not start at those amounts though. I was told to keep increasing the units by 3 a day until I had a decent fasting number or 2 hour post meal number. I don't understand why your endo would tell you not to incr Continue reading >>

Levemir. | Diabetes Forum The Global Diabetes Community

Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community Hi Iainten, I currently take 60 units of Levemir per day. I take 30 in the am and 30 in the pm as split doses works better for me. At the start of the year I was on 64 units of Levemir per day. If you're concerned, speak to your nurse. However, if the 60 units you take works well with your body, then it's not something I would worry about. Hi all. I seem to be on a really high dosage of levemir. I'm taking 60 units every day. Is anyone else like this or should I see nurse. The level of basal insulin (Levemir or Lantus) required will vary from person to person, and the fact that you are taking 60u does not mean that it is too much. Similarly the level of bolus (Humalog or Novorapid) required will depend on your insulin-carb ratio, and this is also different for each person and of course changes through the day. I take 12u Lantus each morning, but that will mean nothing to other diabetics since it is just the level that MY body requires to maintain good background BG control. Have you done basal testing using the well established fasting method (wait atleast 4 hrs after last carb/bolus, then test every hour to check BG remains steady)? If your blood sugar drops by more than 1.7 mmol/l during the test period, the basal rate is probably too high. If it rises by more than 1.7 mmol/l, the rate may be too low. If not how did you find you needed 60u Levemir? This link explains about basal testing, and to convert BG readings from US to UK values just divide them by 18. Continue reading >>