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Lantus Long Or Short Acting

Long-acting Insulin: How It Works

Long-acting Insulin: How It Works

When you eat, your pancreas releases a hormone called insulin. Insulin moves sugar (glucose) from your blood to your cells for energy or storage. If you take insulin, you may need some at mealtime to help lower your blood sugar after you eat. But even between meals, you need insulin in small amounts to help keep blood sugar stable. This is where long-acting insulin comes in. If you have diabetes, either your pancreas can’t produce enough (or any) insulin, or your cells can’t use it efficiently. To control your blood sugar, you need to replace or supplement the normal function of your pancreas with regular insulin injections. Insulin comes in many types. Each type differs in three ways: onset: how quickly it starts working to lower your blood sugar peak: when its effects on your blood sugar are strongest duration: how long it lowers your blood sugar According to the U.S. Food and Drug Administration (FDA), the five types of insulin are: Rapid-acting insulin: This type starts to work just 15 minutes after you take it. It peaks within 30 to 90 minutes, and its effects last for three to five hours. Short-acting insulin: This type takes about 30 to 60 minutes to become active in your bloodstream. It peaks in two to four hours, and its effects can last for five to eight hours. It is sometimes called regular-acting insulin. Intermediate-acting insulin: The intermediate type takes one to three hours to start working. It peaks in eight hours and works for 12 to 16 hours. Long-acting insulin: This type takes the longest amount of time to start working. The insulin can take up to 4 hours to get into your bloodstream. Pre-mixed: This is a combination of two different types of insulin: one that controls blood sugar at meals and another that controls blood sugar between meals. Lo Continue reading >>

Basal Insulins (intermediate And Long-acting)

Basal Insulins (intermediate And Long-acting)

Who? Intermediate- and long-acting (basal) insulins are recommended for patients with type 1, type 2, or gestational diabetes. They may also be used in other types of diabetes (i.e. steroid-induced). Persons with type 1 diabetes generally use intermediate-acting insulin or long-acting insulin in conjunction with regular or rapid acting insulin. Persons with type 2 diabetes may use intermediate or long-acting insulins in conjunction with regular or rapid acting insulins or with oral medications. What? Injections given under the skin. Not suitable for insulin pumps. These medications can be injected with a traditional syringe and needle, or with a disposable pen that has been prefilled with insulin. Most patients tend to prefer pens though while convenient, they can be more expensive. The most common type of intermediate-acting insulin is: NPH (marketed as Humulin N and the Humulin N Pen) NPH (marketed as Novolin N and the Novolin N FlexPen) Long-acting insulins are marketed as different brands. The common ones are: Glargine (marketed as Lantus and the Solo Star Pen) Detemir (marketed as Levemir and the FlexPen) Degludec (marketed as Tresiba and the FlexTouch Pen) Where? These medicines are injected into the tissue under the skin and are slowly released into the body. These insulins allow glucose from the bloodstream to enter the cells in the body so that glucose can be used as energy. They also reduce glucose release into the bloodstream. When? NPH is usually injected twice a day. It begins working 1-3 hours after injection, and is most effective between 4-10 hours of injection. It generally keeps working for 10-16 hours. Detemir can be used once or twice a day. It begins working a few hours after injection and generally keeps working for anywhere from 20-24 hours. Glarg Continue reading >>

How To Use Long-acting Insulin: Types, Frequency, Peak Times, And Duration

How To Use Long-acting Insulin: Types, Frequency, Peak Times, And Duration

Long-acting insulin can help to stabilize blood sugar levels throughout the day, with only one or two shots. Fast-acting insulin replaces the surge of insulin that a healthy pancreas would release at mealtime. In contrast, long-acting insulin mimics the low-level flow of insulin normally released between meals and overnight. In this way, long-acting insulin works to establish a healthy baseline blood sugar level for the body to work around. Contents of this article: Using long-acting insulin Long-acting insulin cannot be delivered in pill form because it would be broken down in the stomach. Instead, it must be injected into the fatty tissue under the skin. From here, it can be gradually released into the bloodstream. Delivery methods According to the National Institute of Diabetes and Digestive and Kidney Diseases, there are a few ways to deliver long-acting insulin. These include: Needle and syringe: a dose of insulin is drawn from a vial into a syringe. Different types of insulin must not be mixed in the same syringe. Pen: this can be loaded with a cartridge containing a premeasured dose, or prefilled with insulin and discarded after use. Injection port: a short tube is inserted into the tissue beneath the skin. Insulin can be delivered using either a syringe or a pen. This only requires the skin to be punctured when the tube needs to be replaced. Injection sites Long-acting insulin can be injected into the abdomen, upper arms, or thighs. Abdomen injections deliver insulin into the blood most quickly. The process takes a little more time from the upper arms, and it is even slower from the thighs. It is important to stay consistent with the general injection area, but the exact injection site should be rotated frequently. Repeat injections at the same spot on the skin Continue reading >>

Types Of Insulin | Lantus (insulin Glargine Injection) 100 Units/ml

Types Of Insulin | Lantus (insulin Glargine Injection) 100 Units/ml

Extreme drowsiness, dizziness, or confusion Other possible side effects may include swelling, weight gain, low potassium levels, injection site reactions, including changes in fat tissue at the injection site, and allergic reactions. Lantus SoloStar is a disposable prefilled insulin pen. Please talk to your healthcare provider about proper injection technique and follow instructions in the Instruction Leaflet that accompanies the pen. Click here for Full Prescribing Information for Lantus. Click here for information on Sharps Medical Waste Disposal. Click here to learn more about Sanofi's commitment to fighting counterfeit drugs. If you are a patient experiencing problems with a Sanofi US product, please contact Sanofi US at 1-800-633-1610. The health information contained herein is provided for general education purposes only. Your healthcare professional is the single best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment. Important Safety Information for Lantus (insulin glargine injection) 100 Units/mL Do not take Lantus during episodes of low blood sugar or if you are allergic to insulin or any of the inactive ingredients in Lantus. Do not share needles, insulin pens, or syringes with others. Do NOT reuse needles. Before starting Lantus, tell your doctor about all your medical conditions, including if you have liver or kidney problems, if you are pregnant or planning to become pregnant or if you are breast-feeding or planning to breast-feed. Heart failure can occur if you are taking insulin together with certain medicines called TZDs (thiazolidinediones), even if you have never had heart failure or other heart problems. If you already have heart failure, it may get worse Continue reading >>

Lantus, Toujeo (insulin Glargine) Dosing, Indications, Interactions, Adverse Effects, And More

Lantus, Toujeo (insulin Glargine) Dosing, Indications, Interactions, Adverse Effects, And More

100 units/mL (Lantus SoloSTAR; Basaglar KwikPen; 3 mL disposable prefilled pens) 300 units/mL (Toujeo; 1.5 mL SoloStar disposable prefilled pen) 300 units/mL (Toujeo Max; 3 mL SoloStar disposable prefilled pen) Note: Recent studies have suggested that glargine-300 extends blood glucose control well beyond 24 hr Long-acting basal insulin indicated to improve glycemic control in adults with type 1 diabetes mellitus Start ~1/3 of total daily insulin dose; use remaining 2/3 of daily insulin dose on short-acting, premeal insulin Usual initial dose range: 0.2-0.4 units/kg; optimal glucose lowering effect may take 5 days to fully manifest and the first insulin glargine dose may be insufficient to cover metabolic needs in the first 24 hr of use Titrate insulin glargine per instructions, and adjust coadministered glucose-lowering therapies per standard of care See Dosing Considerations and Administration Long-acting basal insulin indicated to improve glycemic control in adults with type 2 diabetes mellitus Start 0.2 units/kg qDay; if necessary, adjust dosage of other antidiabetic drugs when starting insulin glargine to minimize the risk of hypoglycemia See Dosing Considerations and Administration Dose must be individualized based on clinical response; blood glucose monitoring is essential in all patients receiving insulin therapy Patients adjusting the amount or timing of dosage should do so only under medical supervision with appropriate glucose monitoring Titrate Toujeo dose no more frequently than every 3-4 days Use with caution in patients with visual impairment who may rely on audible clicks to dial their dose If changing from a treatment regimen with an intermediate- or long-acting insulin to a regimen with insulin glargine, the amount and timing of shorter-acting insulin Continue reading >>

Rapid-acting Versus Long-acting Insulin: What’s The Difference?

Rapid-acting Versus Long-acting Insulin: What’s The Difference?

For people who need to take insulin, there are a couple of different types—long-acting, short-acting, rapid-acting, intermediate-acting, etc. That’s a lot of options! One question I see most often is the difference between rapid-acting and long-acting insulins. So, let’s get into it. What is rapid-acting insulin? Rapid-acting, or meal-time insulin, is a type of insulin that’s usually taken before, during, or after a meal to lower your blood sugar levels associated with meals. How long does it take rapid-acting insulin to begin working? The onset of action varies between rapid-acting insulin products, but can begin working in as little as 5 minutes, or could take as long as 30 minutes, depending on the insulin. The following are the typical onset of action times for each individual rapid-acting insulin products. What is long-acting insulin? Long-acting, or basal insulin, is a type of insulin that gives you a slow steady release of insulin that helps control your blood sugar between meals, and overnight. How long does long-acting insulin last? The duration of action varies between long-acting products but should last anywhere between 22-24 hours. The following are the typical duration of action times for each individual long-acting insulin product: Do I need more than one insulin? Maybe. It’s up to your doctor to determine the best medication regimen for you. Some type 2 diabetes patients may only need to use a long-acting insulin to get their blood sugar control on track; whereas others may need a combination of meal-time and long-acting insulin to best control their blood sugar. If you are using an insulin pump, you will only need to use a rapid or short-acting insulin. The pump is able to give you a slow and steady amount of insulin to cover you all day like Continue reading >>

Types Of Insulin

Types Of Insulin

Topic Overview Insulin is used to treat people who have diabetes . Each type of insulin acts over a specific amount of time. The amount of time can be affected by exercise, diet, illness, some medicines, stress, the dose, how you take it, or where you inject it. The table below is a general guide. Your results may be different. Insulin strength is usually U-100 (or 100 units of insulin in one milliliter of fluid). Short-acting (regular) insulin is also available in U-500. This is five times more concentrated than U-100 regular insulin. Long-acting insulin (glargine) is also available in U-300. This is three times more concentrated than U-100 long-acting insulin. Be sure to check the concentration of your insulin so you take the right amount. Insulin is made by different companies. Make sure you use the same type of insulin consistently. Types of insulin Type Examples Appearance When it starts to work (onset) The time of greatest effect (peak) How long it lasts (duration) Rapid-acting insulins work over a narrow, more predictable range of time. Because they work quickly, they are used most often at the start of a meal. Rapid-acting insulin acts most like insulin that is produced by the human pancreas. It quickly drops the blood sugar level and works for a short time. If a rapid-acting insulin is used instead of a short-acting insulin at the start of dinner, it may prevent severe drops in blood sugar level in the middle of the night. Apidra (glulisine), Humalog (lispro), Novolog (aspart) Clear 5-30 minutes 30 minutes-3 hours 3-5 hours Rapid-acting insulin also comes in a form that can be inhaled through the mouth. Afrezza (insulin human, inhaled) Contained in a cartridge 10-15 minutes 30-90 minutes 2½-3 hours Short-acting insulins take effect and wear off more quickly th Continue reading >>

Insulin Types: Types Of Insulin

Insulin Types: Types Of Insulin

Usually taken before a meal to cover the blood glucose elevation from eating Used with longer-acting insulin Usually taken about 30 minutes before a meal to cover blood glucose elevation from eating Covers the blood glucoseelevations when rapid-acting insulins stop working Often combined with rapid- or short-acting insulin and usually taken twice a day Long acting: insulin glargine , ultralente insulin, insulin detemir Often combined, when needed, with rapid- or short-acting insulin Lowers blood glucose levels when rapid-acting insulins stop working American Diabetes Association. Insulin Basics. April 7, 2014. American Diabetes Association. Available at . Elizabeth Blair. Insulin A to Z: A Guide on Different Types of Insulin. 2015. [Full Text] . Usually taken before a meal to cover the blood glucose elevation from eating Used with longer-acting insulin Usually taken about 30 minutes before a meal to cover blood glucose elevation from eating Covers the blood glucoseelevations when rapid-acting insulins stop working Often combined with rapid- or short-acting insulin and usually taken twice a day Long acting: insulin glargine , ultralente insulin, insulin detemir Often combined, when needed, with rapid- or short-acting insulin Lowers blood glucose levels when rapid-acting insulins stop working Abimbola Farinde, PharmD, PhDFaculty, Columbia Southern University Francisco Talavera, PharmD, PhDAdjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference Disclosure: Received salary from Medscape for employment. for: Medscape. All material on this website is protected by copyright, Copyright 1994-2018 by WebMD LLC. This website also contains material copyrighted by 3rd parties. This website uses cookies to deli Continue reading >>

Different Types Of Insulin: What To Use And When?

Different Types Of Insulin: What To Use And When?

What’s the difference between the different types of insulin? Long-acting, short-acting, premixed, learn more about all three. You may have a lot of questions as you begin insulin therapy. What are the different types of insulin available? Which should I be using and when? Insulins differ based on 3 key factors: 1 how quickly they work when they peak how long they last (duration) This table compares these factors in the types of insulin available:2 Type Onset (How quickly it starts working) Onset (What it is most effective) Duration (How long it works) Timing of injection (When should it be given) Bolus insulins Rapid acting analogues Apidra/Humalog/NovoRapid 10-15 min 1-2 hours 3-5 hours Given with 1 or more meals per day. To be given 0-15 minutes before or after meals. Short-acting Humulin-R/Toronto 30 min 2-3 hours 6.5 hours Given with one or more meals per day. Should be injected 30-45 minutes before the start of the meal. Basal insulins Intermediate-acting Humulin-N/NPH 1-3 hours 5-8 hours Up to 18 hours Often started once daily at bedtime. May be given once or twice daily. Not given at any time specific to meals. Long-acting analogues Lantus Levemir 90 min Not applicable Lantus: Up to 24 hours Levemir: 16-24 hours Often started once daily at bedtime. Insulin detemir (Levemir) may be given once or twice daily. Not given at any time specific to meals. Premixed insulins Premixed regular insulin Humulin 30/70 and Novolin ge 30/70, 40/60, 50/50 Varies according to types of insulin Contains a fixed ratio of insulin (% of rapid-acting or short-acting insulin to % of intermediate-acting insulin): See above for information about peak actions based on insulin contained Given with one or more meals per day. Should be injected 30-45 minutes before the start of the meal. Pre Continue reading >>

What Is Long-acting Insulin?

What Is Long-acting Insulin?

Long-acting insulins are insulin analogs that are steadily released and can last in the body for up to 24 hours. It is often used in the morning or at bedtime as a basal insulin to help control your blood sugar throughout the day. Insulin is made inside the beta cells of the pancreas. It helps regulate the glucose (sugar) in the bloodstream by stimulating the cells to absorb the glucose, which is needed by the cells for energy. Insulin also keeps the liver from producing more glucose. In type 2 diabetes, the body can lose the ability to produce insulin and if insulin is produced, the body isn’t able to use it properly (insulin resistance). Different types of insulin therapies, such as long-acting insulin, enables the body to get the insulin that is needed for optimal glycemic control. Some of the long-acting insulins available in the US include: Levemir contains insulin detemir, which is a long-acting, basal insulin that is used to improve blood sugar control in adults with type 2 diabetes. It can help keep your blood sugar levels within a normal range by moving glucose from the bloodstream into the cells, and it prevents the liver from producing more glucose. Levemir is available in a vial and pre-filled pen called Levemir FlexTouch, each containing 100 units/ml (U-100) of insulin detemir. Once the pen is in use, it is good for 42 days and should not be refrigerated but stored at room temperature (below 86°F). The vial is also good for 42 days after first use, and can be stored in the refrigerator or at room temperature. Levemir is injected under the skin (subcutaneously) in the abdomen, thigh or upper arm once daily, or twice daily depending on your personal requirements. Injection sites should be rotated within the same region from one injection to the next to red Continue reading >>

Types Of Insulin And How They Work - Health

Types Of Insulin And How They Work - Health

Short-acting insulin covers your insulin needs during meals. It is taken about 30 minutes to an hour before a meal to help control blood sugar levels. This type of insulin takes effect in about 30 minutes to one hour, and peaks after two to four hours. Its effects tend to last about five to eight hours. The biggest advantage of short-acting insulin is that you don't have to take it at each meal. You can take it at breakfast and supper and still have good control because it lasts a little longer, Dr. Chandalia says. What its called: Humulin N (NPH), Novolin N (NPH) Intermediate-acting insulin can control blood sugar levels for about 12 hours or longer, so it can be used overnight. It begins to work within one to four hours, and peaks between four and 12 hours, depending on the brand. Intermediate-acting insulin offer baseline insulin coverage and can be used with short-acting insulin or rapid-acting insulin, says Dr. Chandalia. What its called: Lantus (glargine), Levemir (detemir) Long-acting insulin has an onset of one hour, and lasts for 20 to 26 hours with no peak. This insulin type tends to cover your insulin needs for a full day. It is often taken at bedtime. These long-acting insulin provide 24-hour coverage, and have been helpful at achieving good blood sugar control in type 2 diabetes with just one shot, Dr. Chandalia says. What its called: Humulin 70/30, Novolin 70/30, NovoLog 70/30, Humulin 50/50, Humalog mix 75/25, Humalog mix 50/50 This type of insulin combines intermediate- and short-acting insulin. It is often taken twice a day before meals. It should be taken 10 minutes to 30 minutes before eating. Pre-mixed insulin takes effect in 5 to 60 minutes, and its peak times vary. Its effects last from 10 to 16 hours. Pre-mixed insulin was designed to be more con Continue reading >>

Types Of Insulin And Their Roles

Types Of Insulin And Their Roles

Do not take Lantus® during episodes of low blood sugar or if you are allergic to insulin or any of the inactive ingredients in Lantus®. Do not share needles, insulin pens, or syringes with others. Do NOT reuse needles. Before starting Lantus®, tell your doctor about all your medical conditions, including if you have liver or kidney problems, if you are pregnant or planning to become pregnant or if you are breast-feeding or planning to breast-feed. Heart failure can occur if you are taking insulin together with certain medicines called TZDs (thiazolidinediones), even if you have never had heart failure or other heart problems. If you already have heart failure, it may get worse while you take TZDs with Lantus®. Your treatment with TZDs and Lantus® may need to be changed or stopped by your doctor if you have new or worsening heart failure. Tell your doctor if you have any new or worsening symptoms of heart failure, including: Sudden weight gain Tell your doctor about all the medications you take, including OTC medicines, vitamins, and supplements, including herbal supplements. Lantus® should be taken once a day at the same time every day. Test your blood sugar levels while using insulin, such as Lantus®. Do not make any changes to your dose or type of insulin without talking to your healthcare provider. Any change of insulin should be made cautiously and only under medical supervision. Do NOT dilute or mix Lantus® with any other insulin or solution. It will not work as intended and you may lose blood sugar control, which could be serious. Lantus® must only be used if the solution is clear and colorless with no particles visible. Always make sure you have the correct insulin before each injection. While using Lantus®, do not drive or operate heavy machinery until Continue reading >>

Not All Long-acting Insulins Are The Same

Not All Long-acting Insulins Are The Same

Glargine (Lantus) is an insulin analog recently available in the U.S. It is a long-acting insulin but differs from other long-acting insulins (such as NPH, Lente, and ultralente) because it is clear as opposed to cloudy. It also has an acidic pH and should not be mixed with other insulins. Because it is new and patients and physicians do not have a long history of using it, mistakes can occur. A number of our patients have mixed glargine and rapid-acting insulin, in spite of being instructed not to. Additionally, it is no longer possible to distinguish between short- and long-acting insulins by clear or cloudy, respectively. F.R. is a 55-year-old police officer with slowly progressive type 1 diabetes, diagnosed at age 53 years with positive anti-GAD antibodies. As oral agents lost their efficacy, an injection of evening NPH was added to his treatment. Due to his schedule, which involved working 3–4 nights a week, it was impossible to lower his fasting blood glucose levels on a bedtime NPH/daytime oral agents regimen. He was switched to twice-daily NPH and rapid-acting insulin. His HbA1c level remained elevated at 8.8%. When glargine became available he was switched from twice-daily NPH to evening glargine, plus premeal rapid-acting insulin. He was taught carbohydrate counting and was followed closely. His glargine did not seem to control his daytime blood glucose levels, so he was switched to twice-daily injections of glargine. In spite of the new treatment and close follow-up, F.R. seemed to have more erratic blood glucose levels and more unexplained lows and highs than would have been expected on glargine. Therefore, he was put on a continuous glucose sensor to better document his blood glucose levels. His sensor was picked up from his home on a Saturday by one of o Continue reading >>

Types Of Insulin

Types Of Insulin

For people who need to take external or supplemental insulin (insulin your body did not produce but that was instead made by a pharmaceutical company), there are several different types and kinds of insulin. The insulin you take will depend on your personal needs. Different types of insulin work differently in different people. The University of California, San Francisco explains that insulin “was initially extracted from beef and pork pancreases. In the early 1980’s, technology became available to produce human insulin synthetically. Synthetic human insulin has replaced beef and pork insulin in the US. And now, insulin analogs are replacing human insulin.” Here’s a chart of how the types of insulin work to replicate the normal pancreatic delivery of insulin and how they are typically used. Type of Insulin Brand (Generic) Onset Peak Duration Rapid-Acting Apidra (glulisine), Humalog (lispro), Novolog (aspart) 15 minutes 1 or 2 hours 2 to 4 hours Regular- or Short-Acting Humulin R, Novolin R (human recombinant) 30 minutes 2 to 3 hours 3 to 6 hours Intermediate-Acting Humulin N, Novolin N (insulin isophane)) 2 to 4 hours 4 to 12 hours 12 to 18 hours Long-Acting or Basal Insulin Lantus (glargine), Levemir (detemir), Basaglar (glargine) 2 to 4 hours lower peak 24 hours Ultra Long-Acting Toujeo (glargine), Tresiba (degludec) 6 hours small peak 36 hours Inhaled Insulin Afrezza (insulin human) 15 minutes 30 minutes 3 hours Rapid-acting insulin analogs (Insulin Aspart, insulin Lyspro, Insulin Glulisine): Usually taken as a bolus before a meal to cover the blood glucose elevation from eating or to correct for high blood glucose. This type of insulin is often used with longer-acting insulin, which is used to cover the body’s metabolic need for insulin. Short-acting synth Continue reading >>

Types Of Insulin For Diabetes Treatment

Types Of Insulin For Diabetes Treatment

Many forms of insulin treat diabetes. They're grouped by how fast they start to work and how long their effects last. The types of insulin include: Rapid-acting Short-acting Intermediate-acting Long-acting Pre-mixed What Type of Insulin Is Best for My Diabetes? Your doctor will work with you to prescribe the type of insulin that's best for you and your diabetes. Making that choice will depend on many things, including: How you respond to insulin. (How long it takes the body to absorb it and how long it remains active varies from person to person.) Lifestyle choices. The type of food you eat, how much alcohol you drink, or how much exercise you get will all affect how your body uses insulin. Your willingness to give yourself multiple injections per day Your age Your goals for managing your blood sugar Afrezza, a rapid-acting inhaled insulin, is FDA-approved for use before meals for both type 1 and type 2 diabetes. The drug peaks in your blood in about 15-20 minutes and it clears your body in 2-3 hours. It must be used along with long-acting insulin in people with type 1 diabetes. The chart below lists the types of injectable insulin with details about onset (the length of time before insulin reaches the bloodstream and begins to lower blood sugar), peak (the time period when it best lowers blood sugar) and duration (how long insulin continues to work). These three things may vary. The final column offers some insight into the "coverage" provided by the different insulin types in relation to mealtime. Type of Insulin & Brand Names Onset Peak Duration Role in Blood Sugar Management Rapid-Acting Lispro (Humalog) 15-30 min. 30-90 min 3-5 hours Rapid-acting insulin covers insulin needs for meals eaten at the same time as the injection. This type of insulin is often used with Continue reading >>

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