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Januvia Generic

Januvia (sitagliptin) Side Effects, Dose, Cost

Januvia (sitagliptin) Side Effects, Dose, Cost

Januvia | sitagliptin Drug Class: DPP-4 Inhibitor Similar Drugs: Sitagliptin (Januvia), Saxagliptin (Onglyza), Linagliptin (Tradjenta), Alogliptin (Nesina) Manufacturer: Merck Approval Date: March 2007 What is Januvia Januvia (generic name is sitagliptin) reduces blood glucose in individuals with type 2 diabetes by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4). DPP-4 inhibitors increase the amount of two proteins (incretin hormones) found in the body, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). Incretin hormones tell the body to release insulin and lower blood glucose. GLP-1 also decreases the production of glucose and slows down the absorption of glucose. Incretin hormones are removed from the body by an DPP-4. DPP-4 inhibitors like Januvia block this enzyme resulting in GLP-1 and GIP to stay in the body longer and therefore decrease blood glucose levels. What is Januvia used for Januvia is used for treating type 2 diabetes in combination with diet and exercise. It is not used for treating type 1 diabetes. It can be combined with metformin or sulfonylurea. How effective is Januvia Januvia reduced hemoglobin A1C by -0.6% after 24 weeks while A1C increased by 0.2% in the placebo group. 36% of individuals treated with Januvia achieved A1C less than 7% after 24 weeks compared to 14% of individuals treated with placebo. What are interesting facts about Januvia Januvia is excreted by the kidneys Januvia is administered orally once daily Does not cause weight gain Low risk of hypoglycemia Januvia dose & administration Januvia is supplied as 25, 50, and 100 mg tablets. A generic version is not available. The recommended dosage is 100 mg once orally daily. The dose may be reduced in people with poor kidney function. What are the si Continue reading >>

Januvia Side Effects Center

Januvia Side Effects Center

Januvia (sitagliptin) is an oral diabetes medicine for people with type 2 diabetes (non-insulin-dependent) diabetes. Januvia is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes. Many people using Januvia do not have serious side effects. Side effects that may occur with Januvia include: headache, joint or muscle pain, nausea, stomach pain, diarrhea, or constipation. Although Januvia by itself usually does not cause low blood sugar (hypoglycemia), low blood sugar may occur if Januvia is prescribed with other anti-diabetic medications. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. Tell your doctor if you have serious side effects of Januvia including pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, fast heart rate), urinating less than usual or not at all, swelling, weight gain, shortness of breath, or severe skin reaction (fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads [especially in the face or upper body] and causes blistering and peeling). The recommended dose of Januvia is 100 mg once daily. Januvia may interact with digoxin, probenecid, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), or beta-blockers. Tell your doctor all prescription and over-the-counter medications you use. During pregnancy Januvia should be used only when prescribed. Pregnancy may cause or worsen diabetes. Your doctor may change your diabetes treatment during pregnancy. It is unknown if this drug passes into breast milk. Cons Continue reading >>

What Is Januvia®?

What Is Januvia®?

JANUVIA (jah-NEW-vee-ah) is a once-daily prescription pill that, along with diet and exercise, helps lower blood sugar levels in adults with type 2 diabetes. JANUVIA should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUVIA. IMPORTANT SAFETY INFORMATION Serious side effects can happen in people who take JANUVIA, including pancreatitis, which may be severe and lead to death. Before you start taking JANUVIA, tell your doctor if you've ever had pancreatitis. Stop taking JANUVIA and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis. Before you start taking JANUVIA, tell your doctor if you have ever had heart failure (your heart does not pump blood well enough) or have problems with your kidneys. Contact your doctor right away if you have increasing shortness of breath or trouble breathing (especially when you lie down); swelling or fluid retention (especially in the feet, ankles, or legs); an unusually fast increase in weight; or unusual tiredness. These may be symptoms of heart failure. Do not take JANUVIA if you are allergic to any of its ingredients, including sitagliptin. Symptoms of serious allergic reactions to JANUVIA, including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing, can occur. If you have any symptoms of a serious allergic reaction, stop taking JANUVIA and call your doctor right Continue reading >>

Buy Januvia Online, Order Generic Januvia(sitagliptin) Online At Cheap Price.

Buy Januvia Online, Order Generic Januvia(sitagliptin) Online At Cheap Price.

Please note that not all medications, including any referenced on this page, are dispensed from our affiliated Canadian pharmacy. The medications in your order may be filled and shipped from an approved International fulfillment center located in a country other than Canada. In addition to dispensing medications from our Canadian pharmacy, medication orders are also filled and shipped from international fulfillment centers that are approved by the regulatory bodies from their respective countries. Read More Medication orders are filled and shipped from approved fulfillment centers around the world including, but not limited to, Canada, Singapore, United Kingdom, New Zealand, Turkey, Mauritius, India, Australia, and the United States. The items in your order may be filled and shipped from any one of the above jurisdictions. The products are sourced from various countries including, but not limited to, Canada, United Kingdom, New Zealand, Turkey, India, Australia, and the United States. All of our affiliated fulfillment centers have been approved by the regulatory bodies from their respective countries. Sitagliptin phosphate is the active ingredient in the drug Januvia and its inactive ingredients include croscarmellose sodium, microcrystalline cellulose, anhydrous dibasic calcium phosphate, sodium stearyl fumarate and magnesium stearate. The tablet coating contains polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, red iron oxide, and yellow iron oxide. Januvia reduces blood sugar levels by blocking dipeptidyl peptidase IV or DPP-4 enzyme. DPP-4 breaks down proteins that stimulate insulin producing cells after meal. The proteins can activate the release of insulin for longer period if DPP-4 is inhibited, thereby reducing the glucose level in the blood. Thus Continue reading >>

Januvia (sitagliptin) Dosage, Indication, Interactions, Side Effects | Empr

Januvia (sitagliptin) Dosage, Indication, Interactions, Side Effects | Empr

Adjunct to diet and exercise in type 2 diabetes, as monotherapy or combination therapy. Not for treatment of type 1 diabetes or diabetic ketoacidosis. Not studied in patients with history of pancreatitis. 100mg once daily. Renal impairment: eGFR 30<45mL/min/1.73m2: 50mg once daily; eGFR <30mL/min/1.73m2 or ESRD on dialysis: 25mg once daily. Assess renal function before starting therapy and periodically thereafter. Consider risks/benefits in patients with known risk factors for heart failure; monitor for signs/symptoms; evaluate and consider discontinuing if develops. Monitor for signs/symptoms of pancreatitis, serious hypersensitivity reactions, severe joint pain, or bullous pemphigoid; discontinue if suspected or occurs. History of angioedema to other DPP-4 inhibitors. Severe hepatic impairment. Elderly. Pregnancy. Nursing mothers. May need lower dose of concomitant sulfonylurea or insulin to reduce risk of hypoglycemia. Monitor digoxin. Dipeptidyl peptidase-4 (DPP-4) inhibitor. Upper respiratory tract infection, nasopharyngitis, headache; pancreatitis, heart failure, hypersensitivity reactions (eg, anaphylaxis, angioedema, Stevens-Johnson syndrome), severe and disabling arthralgia, bullous pemphigoid. Continue reading >>

Buy Januvia, Generic Januvia (sitagliptin Phosphate) Online At Discount Prices

Buy Januvia, Generic Januvia (sitagliptin Phosphate) Online At Discount Prices

Please note that not all medications, including any referenced on this page, are dispensed from our affiliated Canadian pharmacy. The medications in your order may be filled and shipped from an approved International fulfillment center located in a country other than Canada. In addition to dispensing medications from our Canadian pharmacy, medication orders are also filled and shipped from international fulfillment centers that are approved by the regulatory bodies from their respective countries. Read More Medication orders are filled and shipped from approved fulfillment centers around the world including, but not limited to, Canada, Singapore, United Kingdom, New Zealand, Turkey, Mauritius, India, Australia, and the United States. The items in your order may be filled and shipped from any one of the above jurisdictions. The products are sourced from various countries including, but not limited to, Canada, United Kingdom, New Zealand, Turkey, India, Australia, and the United States. All of our affiliated fulfillment centers have been approved by the regulatory bodies from their respective countries. The active ingredient present in the drug is Sitagliptin and the inactive ingredients include microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, and sodium stearyl fumarate. Coating in the tablet is of polyvinyl alcohol, polyethylene glycol (macrogol), talc, titanium dioxide, red iron oxide, and yellow iron oxide. Sitagliptin belongs to DPP-4 inhibitors group of drug that increases the amount of incretin released by the intestine. Incretin is a type of hormone that increases insulin levels if blood sugar is high which will in turn reduce the amount of sugar in the blood. Sitagliptin works by inhibiting the enzyme di Continue reading >>

Sitagliptin

Sitagliptin

Sitagliptin (INN; /sɪtəˈɡlɪptɪn/ ( listen), previously identified as MK-0431 and marketed as the phosphate salt under the trade name Januvia) is an oral antihyperglycemic (antidiabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class. It was developed, and is marketed, by Merck & Co. This enzyme-inhibiting drug is used either alone or in combination with other oral antihyperglycemic agents (such as metformin or a thiazolidinedione) for treatment of diabetes mellitus type 2.[2] Adverse effects[edit] Side effects are as common with sitagliptin (whether used alone or with metformin or pioglitazone) as they were with placebo, except for rare nausea and common cold-like symptoms, including photosensitivity.[3] No significant difference exists in the occurrence of hypoglycemia between placebo and sitagliptin.[3][4][5] In those taking sulphonylureas, the risk of low blood sugar is increased.[6] The existence of rare case reports of renal failure and hypersensitivity reactions is noted in the United States prescribing information, but a causative role for sitagliptin has not been established.[7] Several postmarketing reports of pancreatitis (some fatal) have been made in people treated with sitagliptin and other DPP-4 inhibitors,[8] and the U.S. package insert carries a warning to this effect,[9] although the causal link between sitagliptin and pancreatitis has not yet been fully substantiated.[2] One study with lab rats published in 2009 concluded that some of the possible risks of pancreatitis or pancreatic cancer may be reduced when it is used with metformin. However, while DPP-4 inhibitors showed an increase in such risk factors, as of 2009, no increase in pancreatic cancer has been reported in individuals taking DPP-4 inhibitors.[10] The updated (August 20 Continue reading >>

What Is Januvia®?[open]

What Is Januvia®?[open]

JANUVIA (jah-NEW-vee-ah) is a once-daily prescription pill that, along with diet and exercise, helps lower blood sugar levels in adults with type 2 diabetes. JANUVIA should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUVIA. IMPORTANT SAFETY INFORMATION Serious side effects can happen in people who take JANUVIA, including pancreatitis, which may be severe and lead to death. Before you start taking JANUVIA, tell your doctor if you've ever had pancreatitis. Stop taking JANUVIA and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis. Before you start taking JANUVIA, tell your doctor if you have ever had heart failure (your heart does not pump blood well enough) or have problems with your kidneys. Contact your doctor right away if you have increasing shortness of breath or trouble breathing (especially when you lie down); swelling or fluid retention (especially in the feet, ankles, or legs); an unusually fast increase in weight; or unusual tiredness. These may be symptoms of heart failure. Do not take JANUVIA if you are allergic to any of its ingredients, including sitagliptin. Symptoms of serious allergic reactions to JANUVIA, including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing, can occur. If you have any symptoms of a serious allergic reaction, stop taking JANUVIA and call your doctor right Continue reading >>

What Are The Possible Side Effects Of Sitagliptin (januvia)?

What Are The Possible Side Effects Of Sitagliptin (januvia)?

A A A Medications and Drugs Brand Names: Januvia Generic Name: sitagliptin (Pronunciation: SI ta glip tin) What is sitagliptin (Januvia)? Sitagliptin is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating. Sitagliptin is for people with type 2 diabetes. Sitagliptin is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes. Sitagliptin may also be used for purposes not listed in this medication guide. What are the possible side effects of sitagliptin (Januvia)? Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking sitagliptin and call your doctor at once if you have a serious side effect such as: pancreatitis - severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, fast heart rate; or urinating less than usual or not at all; swelling, weight gain, feeling short of breath; or severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. Less serious side effects may include: runny or stuffy nose, sore throat; headache, back pain, joint or muscle pain; or This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What is the most important information I should know about sitagliptin (Januvia)? Do not use this medication if you are allergic to sitagliptin or if you are in a state of diabetic ketoa Continue reading >>

Januvia

Januvia

JANUVIA® (sitagliptin) Tablets DESCRIPTION JANUVIA Tablets contain sitagliptin phosphate, an orally-active inhibitor of the dipeptidyl peptidase4 (DPP-4) enzyme. Sitagliptin phosphate monohydrate is described chemically as 7-[(3R)-3-amino-1-oxo-4-(2,4,5trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate (1:1) monohydrate. The empirical formula is C16H15F6N5O•H3PO4•H2O and the molecular weight is 523.32. The structural formula is: Sitagliptin phosphate monohydrate is a white to off-white, crystalline, non-hygroscopic powder. It is soluble in water and N,N-dimethyl formamide; slightly soluble in methanol; very slightly soluble in ethanol, acetone, and acetonitrile; and insoluble in isopropanol and isopropyl acetate. Each film-coated tablet of JANUVIA contains 32.13, 64.25, or 128.5 mg of sitagliptin phosphate monohydrate, which is equivalent to 25, 50, or 100 mg, respectively, of free base and the following inactive ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, and sodium stearyl fumarate. In addition, the film coating contains the following inactive ingredients: polyvinyl alcohol, polyethylene glycol, talc, titanium dioxide, red iron oxide, and yellow iron oxide. For Consumers What are the possible side effects of sitagliptin (Januvia)? Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking sitagliptin and call your doctor at once if you have a serious side effect such as: pancreatitis - severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, fast heart rate; or urinating less than usual Continue reading >>

Indian Court Blocks Generic Of Merck's Januvia

Indian Court Blocks Generic Of Merck's Januvia

Indian court blocks generic of Merck's Januvia Followsa series of setbacks in Indian courts for multinational pharma companies India's Supreme Court has prevented Glenmark Pharmaceuticals from making and selling a generic of Merck & Co's diabetes blockbuster Januvia. The decision validates Merck's patents covering sitagliptin - the active ingredient in Januvia and line extension Janumet (which also contains metformin) - and effectively bars Glenmark from selling its Zita and Zita-Met copies. The court did however allow the Indian drugmaker to sell off any remaining inventory. Merck filed a lawsuit against Glenmark alleging patent infringement in 2013, and the Delhi High Court rejected Merck's petition for an injunction in the same year. In May, the Supreme Court issued a temporary injunction on sales of Glenmark's products, which has now been made permanent. Glenmark had argued that it was using a different salt of sitagliptin in its products that sidestepped Merck's intellectual property, but that position was rejected by the court. It was also unswayed by Glenmark's argument that the lower price it was charging made the availability of its generics a matter of public interest. In India, Merck's MSD Pharmaceuticals subsidiary sells Januvia at 43 rupees a pill - around 20% of the drug's price in the US - compared to 14 rupees per pill for Zita. Licensee Sun Pharma also sells the drug in India on behalf of Merck as Istavel/Istamet. The court ruled that the difference in price was not significant from the perspective of public health. Glenmark was ordered to pay part of Merck's legal fees but was excused compensation. The Januvia/Janumet franchise is Merck's biggest product line, bringing in sales of around $3bn in the first six months of 2015, and a successful defense o Continue reading >>

Buy Januvia 25mg Online, Januvia 25mg, Buy Sitagliptin 25mg, Januvia Generic, Januvia Medication

Buy Januvia 25mg Online, Januvia 25mg, Buy Sitagliptin 25mg, Januvia Generic, Januvia Medication

Januvia is an oral agent approved by the Food and Drug Administration for the treatment of patients with type 2 diabetes whose blood glucose level cannot be controlled effectively with certain medications. You will have to take it in addition to your existing anti-diabetic agent. Januvia, along with your other diabetes medicine, can help better manage your blood glucose levels. To avoid long-term complications, it is necessary to control sugar at normal levels. Sitagliptin, the main ingredient of the medicine is a DPP-4 inhibitor, which acts by increasing the level of a substance in the body that help lower blood sugar. Taking this anti-diabetic agent regularly along with a healthy lifestyle can reduce the risk of developing serious, life-threatening complications such as nerve damage, eye problems, stroke, kidney problems, and heart disease. Januvia can be useful alone or in combination with other anti-diabetic medications to lower blood sugar in patients with type 2 diabetes mellitus. The medicine increases the amount of insulin in the blood as well as reducing the amount of glucose produced by the liver to reduce glucose levels in the blood stream. However, it is still not understood why this anti-diabetic agent reduces the long-term complications associated with diabetes. Januvia tablets are available to purchase online from premiumrxdrugs.com in 25 mg strength. Buy Januvia 25 mg online at a much lower price. Januvia comprises of an active component Sitagliptin, the first and only prescription drug in a new class of oral anti- hyperglycemic agents, which enhances the ability of the body to lower blood glucose level when it is elevated. Consumption of alcohol can affect your blood glucose levels. Avoid drinking alcohol while taking Januvia 25 mg without first discus Continue reading >>

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Buy Januvia And Sitagliptin Phosphate (generic Januvia) Online At The Best Price

Do you want to buy Januvia online but have questions? Call 1-877-275-1525 or contact us through another method. We are here to help. Once you have placed your order for Januvia, you will be provided with instruction on how to submit your doctors prescription. Our mission at CanadaDrugPharmacy.com is to offer Januvia at the most affordable price along with exceptional customer service. We are so confident we have the cheapest price for Januvia, if you find a cheaper price online, use the price beat feature next to the medication and we will beat it. The products listed below either match, relate to, or are possibly therapeutically equivalent to "Januvia". Please note that all prescription products require a VALID PRESCRIPTION written by your doctor to be sent to us to complete your order. Continue reading >>

India's Top Court Rebuffs Merck, Lets Generic Januvia Roll Out

India's Top Court Rebuffs Merck, Lets Generic Januvia Roll Out

India's top court rebuffs Merck, lets generic Januvia roll out India's Supreme Court is keeping the pressure on Western drugmakers. Just days after invalidating a patent for Novartis' ($NVS) cancer drug Glivec, it has said a generic drugmaker there is free, for now, to proceed with its cheap knockoff of Merck's vaunted diabetes drugs. Merck ($MRK) known outside the U.S. as Merck MSD, just two days ago demanded the court stop India's Glenmark Pharmaceuticals from making generic versions of blockbusters Januvia and Janumet, saying it had a patent for the drugs there. Today, the court saidMerck's could move forward with its lawsuit but refused Merck's request for an immediate halt to Glenmark's plans, The Economic Times reports. The decision said the salt used by the Indian company was not generic. Merck said it might appeal. Glenmark intends to sell its versions, called Zita and Zita Met, at a 20% discount to MSD's price of about 1,200 rupees per month. The two drugs are among the top-selling diabetes treatments in India. It was just another indication of how India's highest court is moving when it comes to Western drugmakers and their esteem for patents. Novartis this week lost what was seen as a landmark decision for an Indian patent on its cancer drug Glivec. But it is not alone in feeling the pain from India's penchant for putting its people ahead of patents. The government has issued a compulsory license for Bayer's cancer drug Nexavar and revoked patents on Pfizer's ($PFE) Sutent and Roche's ($RHHBY) Pegasys. Because Western drugmakers like the potential of the Indian market, they are reluctant to just up and depart. Merck has pointed out, for example, that there are about 65 million patients in India being treated for Type 2 diabetes. Continue reading >>

Sitagliptin; Januvia

Sitagliptin; Januvia

are allergic to dapagliflozin or any of the ingredients in FARXIGA. Symptoms of a serious allergic reaction may include skin rash, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. If you have any of these symptoms, stop taking FARXIGA and contact your healthcare provider or go to the nearest hospital emergency room right away have severe kidney problems or are on dialysis. Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with FARXIGA Dehydration (the loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at a higher risk of dehydration if you have low blood pressure; take medicines to lower your blood pressure, including water pills (diuretics); are 65 years of age or older; are on a low salt diet, or have kidney problems Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with FARXIGA. Ketoacidosis is a serious condition which may require hospitalization and may lead to death. Symptoms may include nausea, tiredness, vomiting, trouble breathing, and abdominal pain. If you get any of these symptoms, stop taking FARXIGA and call your healthcare provider right away. If possible, check for ketones in your urine or blood, even if your blood sugar is less than 250 mg/dL Kidney problems. Sudden kidney injury occurred in people taking FARXIGA. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or excessive heat exposure Serious urinary tract infections (UTI), some that lead to hospitalization, occu Continue reading >>

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