diabetestalk.net

Januvia Gastritis

Will You Have Gastritis With Januvia - From Fda Reports - Ehealthme

Will You Have Gastritis With Januvia - From Fda Reports - Ehealthme

A study for a 72 year old man who takes Propecia NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk. You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088). If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Continue reading >>

Januvia Gastritis Side Effect Reports

Januvia Gastritis Side Effect Reports

The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Januvia side effects, such as Gastritis. Gastritis, Metaplasia, Leukocytoclastic Vasculitis, Linear Iga Disease, Purpura, Oral Lichen Planus, Gastric Mucosal Hypertrophy, Hyperplasia, Normochromic Normocytic Anaemia A patient from SWITZERLAND was prescribed and started Januvia on Nov 21, 2011. Patient felt the following Januvia side effects: gastritis, metaplasia, leukocytoclastic vasculitis, linear iga disease, purpura, oral lichen planus, gastric mucosal hypertrophy, hyperplasia, normochromic normocytic anaemia Additional patient health information: male , 80 years of age, weighting 163.1 lb, The consumer reported the following symptoms: was diagnosed with The patient was hospitalized. Although Januvia demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Gastritis, may still occur. Gastritis, Gastritis Erosive, Gastrointestinal Haemorrhage, Haemoglobin Decreased, Microcytic Anaemia, Platelet Count Decreased, Red Blood Cell Count Decreased, Reflux Oesophagitis An adverse event was reported by a physician on Sep 03, 2010 by a male taking Januvia (dosage: NA) was diagnosed with and. Location: JAPAN , 66 years of age, weighting 147.7 lb, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Januvia side effects: gastritis, gastritis erosive, gastrointestinal haemorrhage, haemoglobin decreased, microcytic anaemia, platelet count decreased, red blood cell count decreased, reflux oesophagitis. Additional medications/treatments: Soon after that, the consumer experienced the following of symptoms: The patient was hospitalized. Continue reading >>

Gastroparesis: A Complication Of Diabetes

Gastroparesis: A Complication Of Diabetes

Gastroparesis: A Complication of Diabetes What it is and how it's diagnosed and treated in people with diabetes Reviewed by Amy Hess-Fischl, MS, RD, LDN, BC-ADM, CDE "Gastro" means stomach and "paresis" means impairment or paralysis. If you have diabetes and are experiencing a variety of unpleasant but non-specific digestive symptoms, gastroparesis may be the culprit. Upper abdominal bloating, distention, discomfort, nausea, and vomiting are all symptoms of this disorder. Gastroparesis can occur when the vagus nerve, which controls the movement of food through the digestive tract, stops working or becomes damaged; the movement of food is thus slowed or stopped. If you have this problem, the ability of your stomach to grind up food is reduced or lost entirely. Your system doesnt break up food into smaller pieces, and food stays in the stomach longer than normal instead of moving on to the intestines and the bowel as it should. In diabetes, high blood sugar can contribute to the development of gastroparesis because over a long period of time, if blood sugar levels stay high, diabetes damages the vagus nerve. 1 The stomach is a neuromuscular organ that receives the food we ingest, mixes the food with acid and pepsin, and empties the nutrients into the small intestine for absorption. The stomach or fundus relaxes in order to receive the swallowed food (that's called receptive relaxation). The body and antrum then mix and empty the food using gastric peristalic waves. The peristaltic contractions are paced by electrical events called pacesetter potentials or slow waves. The motility of your GI tract is controlled by an outer sleeve of muscles that surrounds the GI tract. They are controlled by a complex nervous system. Diabetes can damage these nerves, and it is this neurol Continue reading >>

Important Information About The Side Effects Of

Important Information About The Side Effects Of

JANUMET tablets contain 2 prescription medicines: sitagliptin (JANUVIA®) and metformin. Once-daily prescription JANUMET XR tablets contain sitagliptin (the medicine in JANUVIA®) and extended-release metformin. JANUMET or JANUMET XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. JANUMET or JANUMET XR should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUMET or JANUMET XR. Metformin, one of the medicines in JANUMET and JANUMET XR, can cause a rare but serious side effect called lactic acidosis (a buildup of lactic acid in the blood), which can cause death. Lactic acidosis is a medical emergency that must be treated in a hospital. Call your doctor right away if you get any of the following symptoms, which could be signs of lactic acidosis: feel cold in your hands or feet; feel dizzy or lightheaded; have a slow or irregular heartbeat; feel very weak or tired; have unusual (not normal) muscle pain; have trouble breathing; feel sleepy or drowsy; have stomach pains, nausea, or vomiting. Most people who have had lactic acidosis with metformin have other things that, combined with the metformin, led to the lactic acidosis. Tell your doctor if you have any of the following, because you have a higher chance of getting lactic acidosis with JANUMET or JANUMET XR if you: have severe kidney problems or your kidneys are affected by certain x-ray tests that use injectable dye; have liver problems; drink alcohol very often, or drink a lot of alcohol in short-term “binge” drinking; get dehydrated (lose large amounts of body fluids, w Continue reading >>

Asymptomatic Gastritis Associated With Metformin Side Effects In Type 2 Patients

Asymptomatic Gastritis Associated With Metformin Side Effects In Type 2 Patients

Asymptomatic gastritis associated with metformin side effects in type 2 patients Asymptomatic gastritis associated with metformin side effects in type 2 patients Non-symptomatic gastritis is linked with metformin-related gastrointestinal side effects in patients with type 2 diabetes , a study finds. Gastritis occurs when the stomach lining becomes inflamed, which can cause stomach pain, vomiting and bloating following eating. This research comes from Yuxin Huang, MD, and colleagues from Shanghai Huadong Hospital, who obtained data - including demographic and laboratory data - from 144 patients with type 2 diabetes not put on to metformin . All subjects then began metformin treatment at 500 mg per day. This progressively increased over four weeks to 1500 mg per day, with gastrointestinal side effects, such as vomiting and nausea , monitored each week. The dose of metformin was adjusted accordingly depending on patients' symptoms. Following an endoscopy, 64 patients were categorised as non-gastritis subjects, with 80 classed as chronic gastritis subjects. At the beginning of the study, there were no differences in the groups for gastrointestinal symptoms. The mean final metformin dose was 706.24 mg for gastritis patients, which was significantly less than the mean dose used by non-gastritis patients, which was 1,101.56 mg. "Our data show for the first time that asymptomatic chronic gastritis predisposes to metformin-related gastrointestinal side effects," the researchers concluded. "However, the molecular mechanisms are still unclear and merit further investigation." Continue reading >>

Important Safety Information

Important Safety Information

WHAT IS JANUVIA®? JANUVIA (jah-NEW-vee-ah) is a once-daily prescription pill that, along with diet and exercise, helps lower blood sugar levels in adults with type 2 diabetes. JANUVIA should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUVIA. Serious side effects can happen in people who take JANUVIA, including pancreatitis, which may be severe and lead to death. Before you start taking JANUVIA, tell your doctor if you've ever had pancreatitis. Stop taking JANUVIA and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis. Before you start taking JANUVIA, tell your doctor if you have ever had heart failure (your heart does not pump blood well enough) or have problems with your kidneys. Contact your doctor right away if you have increasing shortness of breath or trouble breathing (especially when you lie down); swelling or fluid retention (especially in the feet, ankles, or legs); an unusually fast increase in weight; or unusual tiredness. These may be symptoms of heart failure. Do not take JANUVIA if you are allergic to any of its ingredients, including sitagliptin. Symptoms of serious allergic reactions to JANUVIA, including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing, can occur. If you have any symptoms of a serious allergic reaction, stop taking JANUVIA and call your doctor right away. Kid Continue reading >>

Safety And Tolerability Of Sitagliptin In Patients With Type 2 Diabetes: A Pooled Analysis

Safety And Tolerability Of Sitagliptin In Patients With Type 2 Diabetes: A Pooled Analysis

Safety and tolerability of sitagliptin in patients with type 2 diabetes: a pooled analysis Williams-Herman et al; licensee BioMed Central Ltd.2008 Sitagliptin, a highly selective dipeptidyl peptidase-4 inhibitor, is the first in a new class of oral antihyperglycemic agents (AHAs) for the treatment of patients with type 2 diabetes. Type 2 diabetes is a life-long disease requiring chronic treatment and management. Therefore, robust assessment of the long-term safety and tolerability of newer therapeutic agents is of importance. The purpose of this analysis was to assess the safety and tolerability of sitagliptin by pooling 12 large, double-blind, Phase IIb and III studies up to 2 years in duration. Methods: This analysis included 6139 patients with type 2 diabetes receiving either sitagliptin 100 mg/day (N = 3415) or a comparator agent (placebo or an active comparator) (N = 2724; non-exposed group). The 12 studies from which this pooled population was drawn represent the double-blind, randomized, Phase IIB and III studies that included patients treated with the clinical dose of sitagliptin (100 mg/day) for at least 18 weeks up to 2 years and that were available in a single safety database as of November 2007. These 12 studies assessed sitagliptin as monotherapy, initial combination therapy with metformin, or add-on combination therapy with other oral AHAs (metformin, pioglitazone, sulfonylurea, sulfonylurea + metformin, or metformin + rosiglitazone). Patients in the non-exposed group were taking placebo, pioglitazone, metformin, sulfonylurea, sulfonylurea + metformin, or metformin + rosiglitazone. This safety analysis used patient-level data from each study to evaluate clinical and laboratory adverse experiences. For clinical adverse experiences, the incidence rates of a Continue reading >>

What Patients Say About Janumet 50 1000

What Patients Say About Janumet 50 1000

Janumet 50 1000 ( see details ) is the brand name (and dosage level) of sitagliptin-metformin , a combination prescription drug used in the management of type 2 diabetes . (50 refers to 50 mg of sitagliptin while 1000 refers to 1000 mg of metformin .) In addition to diet and exercise, Janumet 50 1000 is prescribed when the use of metformin or sitagliptin alone does not adequately control the condition. At PatientsLikeMe , where more than 130,000 patients are sharing their experiences with conditions , symptoms , treatments and more, 21 patients report using Janumet 50 1000 or a lower daily dosage (50 mg sitagliptin / 500 mg metformin). What can we learn from these patients experiences? Quite a bit, actually, thanks to PatientsLikeMes unique data-sharing platform. Looking at the three treatment evaluations submitted for Janumet, all three patients rate the effectiveness as Moderate, while side effects were marked as Mild, Moderate and Severe, respectively. The chief complaint from the patient who reported Severe side effects was diarrhea . However, she writes, Blood sugars are going down. What about you? Have you taken Janumet 50 1000 or a different dosage of this combination diabetes medication? Join PatientsLikeMe and add your experiences to our growing body of knowledge. Then, stay to exchange advice and support, research common treatments and learn from other patients like you. Continue reading >>

Effect Of Sitagliptin On Incretin Effect In Patients With Type 2 Diabetes Mellitus

Effect Of Sitagliptin On Incretin Effect In Patients With Type 2 Diabetes Mellitus

You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Sitagliptin on Incretin Effect in Patients With Type 2 Diabetes Mellitus The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. ClinicalTrials.gov Identifier: NCT00551590 Information provided by (Responsible Party): Joerg Schirra, Ludwig-Maximilians - University of Munich Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information The purpose of this study is to assess the effect of the DPP-4 inhibitor sitagliptin on the incretin effect in patients with type 2 diabetes mellitus. Drug: Placebo tablet Drug: Sitagliptin tablet Drug: Saline infusion Drug: Exendin(9-39) infusion Following a meal, gut-produced incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are released into the circulation. Because GLP-1 and GIP mediate grossly 60% of the insulin-stimulatory action, the so-called incretin effect, both are crucial components of a natural endogenous system guaranteeing glucose homeostasis. In addition, GLP-1 lowers glucagon secretion from pancreatic alpha-cells and delays nutrient delivery from the stomach by inhibiting gastric emptying. The rise in insulin concentration enhances glucose clearance in peripheral tissues such as muscle, and the lower glucagon concentration combined with the rise in insulin reduces hepatic glucose production. By enhancing glucose clearance and lowering hepatic glucose production, the post-meal glucose excurs Continue reading >>

Safety And Tolerability Of Sitagliptin In Type 2 Diabetes: Pooled Analysis Of 25 Clinical Studies

Safety And Tolerability Of Sitagliptin In Type 2 Diabetes: Pooled Analysis Of 25 Clinical Studies

Safety and Tolerability of Sitagliptin in Type 2 Diabetes: Pooled Analysis of 25 Clinical Studies Merck Sharp & Dohme Corp., Whitehouse Station, NJ USA Samuel S. Engel, Email: [email protected] . This article has been corrected. See Diabetes Ther. 2013 July 10; 4(2): 487 . This article has been cited by other articles in PMC. In a previous pooled analysis of 19 double-blind clinical studies conducted by Merck, which included data available as of July 2009 on 10,246 patients with type 2 diabetes (T2DM), treatment with sitagliptin was shown to be generally well tolerated compared with treatment with control agents. As the sitagliptin clinical development program continues, additional studies with sitagliptin have been completed. The present analysis updates the safety and tolerability assessment of sitagliptin by examining pooled data from 25 double-blind clinical studies. The present analysis included data from 14,611 patients in 25 studies with T2DM who received either sitagliptin 100mg/day (n=7,726; sitagliptin group) or a comparator agent (n=6,885; non-exposed group). These studies represent all randomized, double-blind trials conducted by Merck that included patients treated with the usual clinical dose of sitagliptin (100mg/day) for between 12weeks and 2years, and for which results were available as of December 2011. These studies assessed sitagliptin, versus comparator agents, taken as monotherapy, initial combination therapy with metformin or pioglitazone, or as add-on combination therapy with other antihyperglycemic agents (metformin, pioglitazone, a sulfonylureametformin, insulinmetformin, or metformin+pioglitazone or rosiglitazone). Patient-level data from each study were used to evaluate between-group differences in the exposure-adjusted incidence rates Continue reading >>

Januvia : Januvia 100mg Side Effects, Januvia Tabletten 50 Mg, Januvia Cost Walmart

Januvia : Januvia 100mg Side Effects, Januvia Tabletten 50 Mg, Januvia Cost Walmart

Januvia 100mg side effects januvia 100 mg 28 tablet Je taky divn si je nechat poslat z Ruska do USA. El metronidazol es un profrmaco, atarax tablets 25mg convertido en los organismos anaerbicos por las enzimas redox piruvato- ferredoxina oxidorreductasa. After a search of the house and premises on the morning of the tragedy, Dr. Clinical experience with ZOLOFT in patients with certain concomitant systemic illness is limited. Ferritin and serum iron levels fall with iron deficiency. You may also find it helpful to share this information with your partner. corrodens but not into Moraxella catarrhalis, which carries nonmobile tet(B) rather than tet(M) ( 132, 240). Incluso cuando su nio parezca estar mejor, januvia 10mg valiumdespus de haber tenido un problema de asma, las vas respiratorias pueden seguir inflamadas durante 6 a 8 semanas o ms. Faustus and was rescued by Falcon with the help of Sharon Carter, januvia 50 mg tabletswho was pretending to still be under Faustus' control. Anyway, zestril 10 mg price in pakistan should you have any suggestions or techniques for new blog owners please share. Benefits, januvia 100mg side effectsincluding Points issued during one-off promotions (e.g. Although some authors have suggested that examinations should be conducted for 2 weeks after negative findings of an initial examination [ 137], these recommendations are based on small numbers of patients. I have looked everywhere but I still can't find any information. Don't buy Valtrex from places like Asia, zyrtec target price India or South America or the Caribbean. Typically, only extreme conduct rising to a due process violation is going to necessitate recusal in Texas. Elastic bandaging does not offer the same lateral and medial support. Famciclovir (Famvir): Famciclovir is the p Continue reading >>

Juvisync (sitagliptin And Simvastatin): Side Effects, Interactions, Warning, Dosage & Uses

Juvisync (sitagliptin And Simvastatin): Side Effects, Interactions, Warning, Dosage & Uses

JUVISYNC Tablets contain sitagliptin phosphate, an orally-activeinhibitor of the dipeptidyl peptidase -4 (DPP-4) enzyme, and simvastatin, a lipid -lowering agent that is derived synthetically from a fermentation productof Aspergillus terreus. Sitagliptin phosphate monohydrate is described chemicallyas 7-[(3R)-3-amino-1-oxo-4-(2,4,5trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazinephosphate (1:1) monohydrate. The empirical formula is C16H15F6N5OH3PO4H2Oand the molecular weight is 523.32. The structural formula is: Sitagliptin phosphate monohydrate is a white tooff-white, crystalline, non-hygroscopic powder. It is soluble in water andN,N-dimethyl formamide; slightly soluble in methanol; very slightly soluble inethanol, acetone , and acetonitrile; and insoluble in isopropanol and isopropylacetate. After oral ingestion, simvastatin, which is an inactivelactone, is hydrolyzed to the corresponding -hydroxyacid form. This isan inhibitor of 3-hydroxy-3-methylglutaryl- coenzyme A (HMG-CoA) reductase. Thisenzyme catalyzes the conversion of HMG-CoA to mevalonate, which is an early andrate-limiting step in the biosynthesis of cholesterol . Simvastatin is butanoic acid,2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4hydroxy-6-oxo-2H-pyran-2-yl)-ethyl]-1-naphthalenylester, [1S-[1,3,7,8(2S*,4S*),-8a]]. Theempirical formula of simvastatin is C25H38O5and its molecular weight is 418.57. Its structural formula is: Simvastatin is a white to off-white, nonhygroscopic,crystalline powder that is practically insoluble in water, and freely solublein chloroform , methanol and ethanol. Each bilayer tablet of JUVISYNC contains 128.5 mg or64.25 mg of sitagliptin phosphate monohydrate, which is equivalent to 100 mg or50 mg of free base, r Continue reading >>

Anyone Struggling With Gastritis?

Anyone Struggling With Gastritis?

I don't eat anything these days I haven't eaten before, and I've never had any intolerance or had any GI issues at all in my life. In the not too distant past you said you've had a history of digestive issues all your life. My digestion has never been that great and all my life I've generally eaten just one big meal a day and then a day later it's digested and I'm ready to eat again. I'm not sure what proof you're looking for here Nicole, I am totally convinced, that's enough for me Martin, this is gastritis, which I've never had, not slow digestion, which I've had but it never caused me problems really and in fact was a benefit if anything, I could go a long time without eating and feel great. These are entirely different conditions. When I said GI issues I meant illnesses and I never got sick from that at all. Sorry for the confusion D.D. Family T2 since 2005, Control via LCHF/Exercise, No Meds I never had any digestion or stomach problems since I was a child. I started on Metformin (Glucovance) when I was first diagnosed and noticed some very minor problems (a bit of nausea once in a while after taking my meds), but nothing serious to affect my eating. I still had a voracious appetite. A few months ago I went on insulin and changed to Janumet, which is Metformin + Januvia. Not sure why, but the stomach problems hit with a vengeance almost immediately. Everything I read indicates that it's likely the Metfomin, but I don't understand why it wasn't a major issue with my previous medication. My doc says the insulin shouldn't have made any difference. The dosage stayed the same. Anyways, my solution was simply to cut back on my food intake. I quickly found that eating more than about 600 ~ 700 calories at any one meal initiated some pain in my stomach and if I kept on, I Continue reading >>

Januvia Pancreatitis Side Effects

Januvia Pancreatitis Side Effects

Users of the diabetes drugs Januvia or Janumet should be aware that the medications have been associated with a number of cases of pancreatitis, which may be caused by side effects of Januvia. The FDA issued an alert today to notify doctors and consumers about revisions to the warning label regarding post-marketing reports of acute pancreatitis, including severe forms, hemorrhagic pancreatitis and necrotizing pancreatitis. Between October 2006 and February 2009, the FDAs Adverse Event Reporting System has identified at least 88 cases of acute pancreatitis associated with the use of Januvia (sitagliptin) and Janumet, which combines Januvia with metformin. The actual number of Januvia pancreatitis cases is likely substantially higher, as reported events usually only account for between 1% and 10% of all occurrences. Some concerning information provided by the FDA about the Januvia pancreatitis side effects include: 66% of the cases resulted in hospitalization for pancreatitis 4 cases required treatment in an intensive care unit (ICU) 2 cases involved severe cases of hemorrhagic or necrotizing pancreatitis, which can be fatal in many cases 21% of the cases had pancreatitis develop within 30 days of starting Januvia or Janumet 53% of the cases resolved once the medication was stopped 49% of the cases were not associated with other risk factors for developing pancreatitis The most common pancreatitis symptoms from Januvia were abdominal pain, nausea and vomiting According to the information provided to healthcare professions about the Januvia pancreatitis warning , the FDA concluded: Based on the temporal relationship of initiating sitagliptin (Januvia) or sitagliptin/metformin (Janumet) and development of acute pancreatitis in reviewed cases, FDA believes there may be an a Continue reading >>

Janumet (sitagliptin-metformin) Patient Reviews

Janumet (sitagliptin-metformin) Patient Reviews

Janumet 50 1000 ( see details ) is the brand name (and dosage level) of sitagliptin-metformin , a combination prescription drug used in the management of type 2 diabetes . (50 refers to 50 mg of sitagliptin while 1000 refers to 1000 mg of metformin .) In addition to diet and exercise, Janumet 50 1000 is prescribed when the use of metformin or sitagliptin alone does not adequately control the condition. At PatientsLikeMe , where more than 130,000 patients are sharing their experiences with conditions , symptoms , treatments and more, 21 patients report using Janumet 50 1000 or a lower daily dosage (50 mg sitagliptin / 500 mg metformin). What can we learn from these patients experiences? Quite a bit, actually, thanks to PatientsLikeMes unique data-sharing platform. Looking at the three treatment evaluations submitted for Janumet, all three patients rate the effectiveness as Moderate, while side effects were marked as Mild, Moderate and Severe, respectively. The chief complaint from the patient who reported Severe side effects was diarrhea . However, she writes, Blood sugars are going down. What about you? Have you taken Janumet 50 1000 or a different dosage of this combination diabetes medication? Join PatientsLikeMe and add your experiences to our growing body of knowledge. Then, stay to exchange advice and support, research common treatments and learn from other patients like you. Continue reading >>

More in diabetes