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Merck Sharp & Dohme Launches Januvia In China To Join Race In Second-largest Diabetes Market

Merck Sharp & Dohme Launches Januvia In China To Join Race In Second-largest Diabetes Market

Merck Sharp & Dohme Launches Januvia In China To Join Race In Second-largest Diabetes Market This article was originally published in PharmAsia News PharmAsia News @PharmAsiaNews [email protected] SHANGHAI - Having received approval from China's State FDA for Januvia (sitagliptin), Merck Sharp & Dohme announced March 21 that it has launched the dipeptidyl peptidase-4 inhibitor for Type 2 diabetes and joined the race to compete in China's $300 million oral diabetes drug market Already Registered? Sign in to continue reading. Thanks, we've sent a link to reset your password Enter the email address associated with your account and an email will be sent to you to reset your password. Unfortunately we've not been able to process this request. Phone:(US Toll-Free): +1 888-670-8900; (US Collect): +1 908-547-2200 Phone (UK & Europe): +44 (20) 337 73737 New to Scrip? Request a free trial today! Thanks, we've sent a link to reset your password Enter the email address associated with your account and an email will be sent to you to reset your password. Unfortunately we've not been able to process this request. Phone:(US Toll-Free): +1 888-670-8900; (US Collect): +1 908-547-2200 Phone (UK & Europe): +44 (20) 337 73737 Thanks, we've sent a link to reset your password Enter the email address associated with your account and an email will be sent to you to reset your password. Unfortunately we've not been able to process this request. Phone:(US Toll-Free): +1 888-670-8900; (US Collect): +1 908-547-2200 Phone (UK & Europe): +44 (20) 337 73737 Your username does not meet the requirements. Sorry - this email domain is not allowed. Sorry - public email accounts are not allowed. Please provide a work email address. An account with that username already exists. Unfortunately we've not Continue reading >>

Welcome 7367

Welcome 7367

Activate & Print a Coupon to Replace a Lost Coupon STEP 2: Review and accept the Terms and Conditions of the coupon: The coupon is valid for up to $150 off your out-of-pocket cost, on each of up to 12 qualifying prescriptions for JANUVIA, JANUMETXR, or JANUMET (regardless of the quantity supplied on the prescription). Patient is responsible for the first $5 of their out-of-pocket cost. Coupon is valid for use 12 times only. Patient must have a co-payment (or, if privately insured without coverage for JANUVIA, JANUMETXR, or JANUMET make full cash payment) for the prescription. Savings are limited to amount of your out-of-pocket cost over $5, up to a maximum of $150 per prescription for up to 12 qualifying prescriptions. The coupon may be redeemed only once every 21 days. The coupon is not transferable. No substitutions are permitted. The offer cannot be combined with any other coupon, free trial, discount, prescription savings card, or other offer. Patient must have private insurance. Not valid for uninsured patients or patients covered under Medicaid (including Medicaid patients enrolled in a qualified health plan purchased through a health insurance exchange [marketplace] established by a state government or the federal government), Medicare, a Medicare Part D or Medicare Advantage plan (regardless of whether a specific prescription is covered), TRICARE, CHAMPUS, Puerto Rico Government Health Insurance Plan ("Healthcare Reform"), or any other state or federal medical or pharmaceutical benefit program or pharmaceutical assistance program (collectively, "Government Programs"). You must be 18 years of age or older to redeem the coupon. Patient, pharmacist, and prescriber agree not to seek reimbursement for all or any part of the benefit received by the patient through th Continue reading >>

Sitagliptin (oral Route)

Sitagliptin (oral Route)

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects. This medicine may cause serious allergic reactions, including anaphylaxis, angioedema, or certain skin conditions (Stevens-Johnson syndrome). These reactions can be life-threatening and require immediate medical attention. Call your doctor right away if you have a rash, itching, blistering, peeling, or loose skin, fever or chills, trouble breathing or swallowing, or any swelling of your hands, face, mouth, or throat while you are using this medicine. Pancreatitis (swelling and inflammation of the pancreas) may occur while you are using this medicine. Check with your doctor right away if you have a sudden and severe stomach pain, chills, constipation, nausea, vomiting, loss of appetite, fever, or lightheadedness. This medicine may cause hypoglycemia (low blood sugar). Low blood sugar can also occur if you delay or miss a meal or snack, exercise more than usual, drink alcohol, cannot eat because of nausea or vomiting, take certain medicines, or take sitagliptin with another type of diabetes medicine (eg, insulin, glimepiride, metformin, or pioglitazone). Symptoms of low blood sugar must be treated before they cause you to pass out (unconsciousness). People feel different symptoms with low blood sugar. It is important that you learn which symptoms you usually have so you can treat it quickly. Symptoms of low blood sugar include anxiety, behavior changes similar to being drunk, blurred vision, cold sweats, confusion, cool, pale skin, difficulty with thinking, drowsiness, excessive hunger, a fast heartbeat, headaches that continue, na Continue reading >>

Sitagliptin

Sitagliptin

Sitagliptin (INN; /sɪtəˈɡlɪptɪn/ ( listen), previously identified as MK-0431 and marketed as the phosphate salt under the trade name Januvia) is an oral antihyperglycemic (antidiabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class. It was developed, and is marketed, by Merck & Co. This enzyme-inhibiting drug is used either alone or in combination with other oral antihyperglycemic agents (such as metformin or a thiazolidinedione) for treatment of diabetes mellitus type 2.[2] Adverse effects[edit] Side effects are as common with sitagliptin (whether used alone or with metformin or pioglitazone) as they were with placebo, except for rare nausea and common cold-like symptoms, including photosensitivity.[3] No significant difference exists in the occurrence of hypoglycemia between placebo and sitagliptin.[3][4][5] In those taking sulphonylureas, the risk of low blood sugar is increased.[6] The existence of rare case reports of renal failure and hypersensitivity reactions is noted in the United States prescribing information, but a causative role for sitagliptin has not been established.[7] Several postmarketing reports of pancreatitis (some fatal) have been made in people treated with sitagliptin and other DPP-4 inhibitors,[8] and the U.S. package insert carries a warning to this effect,[9] although the causal link between sitagliptin and pancreatitis has not yet been fully substantiated.[2] One study with lab rats published in 2009 concluded that some of the possible risks of pancreatitis or pancreatic cancer may be reduced when it is used with metformin. However, while DPP-4 inhibitors showed an increase in such risk factors, as of 2009, no increase in pancreatic cancer has been reported in individuals taking DPP-4 inhibitors.[10] The updated (August 20 Continue reading >>

Januvia New Fda Drug Approval | Centerwatch

Januvia New Fda Drug Approval | Centerwatch

Januvia is an orally-active inhibitor of the dipeptidylpeptidase-4 (DPP-4) enzyme. The DPP-4 enzyme inactivates incretinhormones, which are involved in the physiologic regulation ofglucose homeostasis. By inhibiting DPP-4, Januvia increases andprolongs active incretin levels. This in turn increases insulinrelease and decreases glucagon levels in the circulation in aglucose-dependent manner. Januvia is specifically indicated for the improvement ofglycemic control in patients with type II diabetes mellitus asmonotherapy or combination therapy with metformin or a peroxisomeproliferatoractivated receptor gamma (PPAR) agonist (e.g.,thiazolidinediones) when the single agent does not provide adequateglycemic control. Januvia is supplied as 25 mg, 50 mg or 100 mg tablets designedfor oral administration. The recommended initial dose of the drugis 100 mg once daily. FDA approval of Januvua was based on the pooled results of twodouble-blind, placebo controlled monotherapy studies and twodouble-blind, placebo controlled combination therapy studies. The Januvia monotherapy trials had one with an 18 week durationand one with a 24 week duration. In the 18-week study, 521 subjectswere randomized to placebo, Januvia 100 mg, or Januvia 200 mg, andin the 24-week study 741 subjects were randomized to placebo,Januvia 100 mg, or Januvia 200 mg. In both trials subjects wentunder a 7 week washout period then completed a 2-week,single-blind, placebo run-in period, before receiving treatment.Treatment with Januvia at 100 mg daily provided significantimprovements in A1C, FPG, and 2-hour PPG compared to placebo. Inthe 18-week study, 9% of patients receiving Januvia 100 mg and 17%who received placebo required rescue therapy. In the 24-week study,9% of patients receiving Januvia 100 mg and 21% of p Continue reading >>

Prescription Co-pay Patient Assistance Programs | Mckesson

Prescription Co-pay Patient Assistance Programs | Mckesson

Print, including program materials, direct mail, and ongoing fulfillment Operational integration to hub services for applicable brands Customized medical benefit co-pay assistance programs Specialty brands often require medical benefit co-pay programs, particularly for infused and in-office administered products . Depending on a patients product portfolio and provider coverage, brands may offer medical or pharmacy benefit supportor both. Our team of experts will work to understand your financial support needs, building an integrated co-pay solution to help you serve patients and promote loyalty. We engage and educate provider staff in the processes of enrollment, claims submission and payment. We also provide ongoing adherence coaching for patients to help them overcome barriers, set expectations and deter dropoff. Our medical co-pay program is a simple process that follows these steps: The provider faxes a claim form, along with the patients commercial insurance evidence of benefits (EOB), to bill the program. Each claim gets reviewed for compliance with the program rules. (This step ensures only eligible providers and patients receive reimbursement for covered products.) The medical co-pay program provides prompt payment to the provider by check or direct deposit. With each claim, the provider receives an EOB that clearly communicates the patients program status and remaining benefits. Are you a patient looking for co-pay assistance? Patients seeking co-pay assistance for specific drugs should visit the manufacturers website. For replacement cards and support for pharmacists, please visit copayhelp.mckesson.com . Continue reading >>

Januvia (sitagliptin) | Official Site For Health Care Professionals

Januvia (sitagliptin) | Official Site For Health Care Professionals

References: 1. Goldstein BJ, Feinglos MN, Lunceford JK, et al; for Sitagliptin 036 Study Group. Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes. Diabetes Care. 2007;30(8):19791987. 2. Barzilai N, Guo H, Mahoney EM, et al. Efficacy and tolerability of sitagliptin monotherapy in elderly patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Curr Med Res Opin. 2011;27(5):10491058. 3. Nauck MA, Meininger G, Sheng D, et al; for Sitagliptin Study 024 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, non-inferiority trial. Diabetes Obes Metab. 2007;9(2):194205. 4. Arechavaleta R, Seck T, Chen Y, et al. Efficacy and safety of treatment with sitagliptin or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy: a randomized, double-blind, non-inferiority trial. Diabetes Obes Metab. 2011;13(2):160168. Selected Important Risk Information About JANUVIA (sitagliptin) tablets JANUVIA is contraindicated in patients with a history of a serious hypersensitivity reaction to sitagliptin, such as anaphylaxis or angioedema. There have been postmarketing reports of acute pancreatitis, including fatal and nonfatal hemorrhagic or necrotizing pancreatitis, in patients taking JANUVIA. After initiating JANUVIA, observe patients carefully for signs and symptoms of pancreatitis. If pancreatitis is suspected, promptly discontinue JANUVIA and initiate appropriate management. It is unknown whether patients with a history of pancreatitis are at incr Continue reading >>

To View Pdf Documents, You Must Have Adobe Reader Installed On Your Computer

To View Pdf Documents, You Must Have Adobe Reader Installed On Your Computer

JANUMET tablets contain 2 prescription medicines: sitagliptin (JANUVIA®) and metformin. Once-daily prescription JANUMET XR tablets contain sitagliptin (the medicine in JANUVIA®) and extended-release metformin. JANUMET or JANUMET XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. JANUMET or JANUMET XR should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUMET or JANUMET XR. Selected Risk Information About JANUMET and JANUMET XR Metformin, one of the medicines in JANUMET and JANUMET XR, can cause a rare but serious side effect called lactic acidosis (a buildup of lactic acid in the blood), which can cause death. Lactic acidosis is a medical emergency that must be treated in a hospital. Call your doctor right away if you get any of the following symptoms, which could be signs of lactic acidosis: feel cold in your hands or feet; feel dizzy or lightheaded; have a slow or irregular heartbeat; feel very weak or tired; have unusual (not normal) muscle pain; have trouble breathing; feel sleepy or drowsy; have stomach pains, nausea, or vomiting. Most people who have had lactic acidosis with metformin have other things that, combined with the metformin, led to the lactic acidosis. Tell your doctor if you have any of the following, because you have a higher chance of getting lactic acidosis with JANUMET or JANUMET XR if you: have severe kidney problems or your kidneys are affected by certain x-ray tests that use injectable dye; have liver problems; drink alcohol very often, or drink a lot of alcohol in short-term “binge” drinkin Continue reading >>

Januvia Prices, Coupons And Patient Assistance Programs

Januvia Prices, Coupons And Patient Assistance Programs

Important: When there is a range of pricing, consumers should normally expect to pay the lower price. However, due to stock shortages and other unknown variables we cannot provide any guarantee. The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions. Please note: This is a drug discount program, not an insurance plan. Valid at all major chains including Walgreens, CVS Pharmacy, Target, WalMart Pharmacy, Duane Reade and 65,000 pharmacies nationwide. Januvia offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples. Some offers may be printed right from a website, others require registration, completing a questionnaire, or obtaining a sample from the doctor's office. Januvia Savings Coupon: Commercially Insured Patients - Pay as little as $5 on each of up to 12 prescriptions with savings of up to $150 per month; saving coupon may be redeemed every 21 days; for additional information contact the program at 800-727-5400. Continue reading >>

Januvia Coupons & Manufacturer Offers 2018 - 50% Off

Januvia Coupons & Manufacturer Offers 2018 - 50% Off

Januvia is a gliptin medication prescribed to control blood sugar levels in type 2 diabetes patients. This medication increases insulin released by your body and decreasing the amount of excess sugar made by your body. The quantity and dosage of... More Januvia is a gliptin medication prescribed to control blood sugar levels in type 2 diabetes patients. This medication increases insulin released by your body and decreasing the amount of excess sugar made by your body. The quantity and dosage of Januvia must be balanced with the type of food you eat and the amount of exercise you do. A one-month supply (30 tablets) of Januvia costs over $350 at your local pharmacy. This medication can be difficult to afford without a Januvia copay card or patient assistance. We provide Januvia coupons and access to other savings options to help you lower the retail price. Read more about Januvia and our discounts below. We also offer a free discount card for Januvia and many other prescription drugs, which give you the opportunity to save up to 75%. Just click FREE discount card on the right side of our home page or select Get card in mail when choosing your Januvia coupon form. The Januvia discount card will be sent to you in the mail within two weeks. Simply register to receive your card and start saving today! Read information about Januvia below to learn about its common uses. If you have questions about this medicine, please consult with your doctor or pharmacist and be sure to inform them of all the medications you are currently taking. Januvia is used to treat type 2 diabetes patients by lowering blood sugar levels and improving glycemic control. This medication is used in combination with a diet and exercise program. Do not take Januvia if you are a type 1 diabetes patient. Poss Continue reading >>

Merck Patient Assistance Programs To Help Those In Need - Official Site

Merck Patient Assistance Programs To Help Those In Need - Official Site

EMEND (aprepitant)80 mg, 125 mg capsules EMEND (fosaprepitant dimeglumine)for Injection 150 mg EMEND (aprepitant)for Oral Suspension 125 mg GARDASIL9 (Human Papillomavirus 9-valent Vaccine, Recombinant) INTRON A (interferon alfa-2b, recombinant) for Injection ISENTRESS (raltegravir)400 mg film-coated and 25 mg and 100 mg chewable Tablets ISENTRESS HD (raltegravir)400 and 600 mg film-coated and 25 mg and 100 mg chewable Tablets JANUMET (sitagliptin and metformin HCI)Tablets JANUMET XR (sitagliptin and metformin HCI extended-release) Tablets KEYTRUDA (pembrolizumab)Injection [liquid formulation] 100 mg LOTRISONE (clotrimazole and betamethasone dipropionate)Cream M-M-R II (Measles, Mumps, and Rubella Virus Vaccine Live) MAXALT-MLT 10mg (rizatriptan benzoate)Orally Disintegrating Tablets MAXALT 10mg (rizatriptan benzoate)Tablets, for oral use NASONEX (mometasone furoate monohydrate)Nasal Spray NOXAFIL (posaconazole)delayed-release tablets 100 mg NOXAFIL (posaconazole)oral suspension, 40 mg/mL PNEUMOVAX23 (Pneumococcal Vaccine Polyvalent) PRIMAXIN I.V. (imipenem and cilastatin for injection) RECOMBIVAX HB [Hepatitis B Vaccine (Recombinant)] RENFLEXIS (infliximab-abda)for injection, for intravenous use SINGULAIR (montelukast sodium)Oral Granules SIVEXTRO (tedizolid phosphate)tablet, for oral use EMEND (aprepitant)80 mg, 125 mg capsules EMEND (fosaprepitant dimeglumine)for Injection 150 mg EMEND (aprepitant)for Oral Suspension 125 mg GARDASIL9 (Human Papillomavirus 9-valent Vaccine, Recombinant) INTRON A (interferon alfa-2b, recombinant) for Injection ISENTRESS (raltegravir)400 mg film-coated and 25 mg and 100 mg chewable Tablets ISENTRESS HD (raltegravir)400 and 600 mg film-coated and 25 mg and 100 mg chewable Tablets JANUMET (sitagliptin and metformin HCI)Tablets JANUMET XR Continue reading >>

What Is Januvia®?[open]

What Is Januvia®?[open]

JANUVIA (jah-NEW-vee-ah) is a once-daily prescription pill that, along with diet and exercise, helps lower blood sugar levels in adults with type 2 diabetes. JANUVIA should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUVIA. IMPORTANT SAFETY INFORMATION Serious side effects can happen in people who take JANUVIA, including pancreatitis, which may be severe and lead to death. Before you start taking JANUVIA, tell your doctor if you've ever had pancreatitis. Stop taking JANUVIA and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis. Before you start taking JANUVIA, tell your doctor if you have ever had heart failure (your heart does not pump blood well enough) or have problems with your kidneys. Contact your doctor right away if you have increasing shortness of breath or trouble breathing (especially when you lie down); swelling or fluid retention (especially in the feet, ankles, or legs); an unusually fast increase in weight; or unusual tiredness. These may be symptoms of heart failure. Do not take JANUVIA if you are allergic to any of its ingredients, including sitagliptin. Symptoms of serious allergic reactions to JANUVIA, including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing, can occur. If you have any symptoms of a serious allergic reaction, stop taking JANUVIA and call your doctor right Continue reading >>

Januvia - Savings Tips - Goodrx

Januvia - Savings Tips - Goodrx

Many manufacturers offer programs that will reduce your out-of-pocket costs for this prescription. These programs are free but may have some rules or restrictions, so youll want to review carefully. When youre ready to use this coupon, simply present the coupon to your pharmacist with a valid prescription for your medication. Register online to download and print a card. You can also activate or replace a card online. Your co-pay can be reduced to as little as $5 per month, with a maximum total benefit of $2000. Yes. The card is for commercially insured patients only. You may call to request a mail-in rebate if your pharmacist is unable to process the discount. Many programs are available from federal and state governments, non-profits, manufacturers, and other organizations to help you get the drugs you need at a reduced cost. Eligibility is often based on income, insurance or Medicare status, and other factors. Youll need to apply through each program, either online, over the phone, or with your doctor's help. The following program is offered by the manufacturer of this drug. Go to the program website and follow the instructions on the page based on your medication. Ask your doctor to help you fill out an enrollment form. The application can be submitted by mail or fax. You can receive your medication at no cost. Most people without insurance and with limited incomes will qualify. Insured and Medicare Part D patients may still be eligible for the program under certain eligibility criteria. Contact the program to find out more. You may find that filling a 90-day supply will reduce your total cost for this prescription. As an added bonus, you'll make fewer trips to the pharmacy, saving you time and money. If you have insurance or Medicare, you may find that you receive Continue reading >>

Januvia Medication Side Effects Lawsuit Medical Record

Januvia Medication Side Effects Lawsuit Medical Record

Januvia (Sitagliptin) is an oral antidiabetic medicine belonging to class dipeptidyl peptidase-4 (DPP-4) inhibitor, manufactured by Merck & Co., was approved by the U.S. Food and Drug Administration (FDA) in 2006. In 2007, the FDA approved a variation of Januvia called Janumet, which is a combination of sitagliptin and metforminand is also made by Merck. Sitagliptin is an anti-diabetic drug that works by increasing the levels of natural substances called incretins. Incretins help to control blood sugar by increasing insulin release, especially after a meal. They also decrease the amount of sugar your liver makes. It works by regulating the levels of insulin your body produces after eating. In 2011, the FDA received almost 200 reports of acute and chronic pancreatitis linked to Januvia some of which were fatal. In 2015, the FDA warned Januvia (and Janumet) could cause severe joint pain. The most serious injuries associated with Januvia are acute pancreatitis, pancreatic cancer, and thyroid cancer. In June 2015, the FDA warned that the type 2 diabetes medicines Sitagliptin (and saxagliptin, linagliptin, and alogliptin) may cause joint pain, which can be severe and disabling. The FDA has added a new Warning and Precaution about this risk to the labels of all medicines in the DPP-4 inhibitors. Lawsuits against the makers of Type 2 diabetes drugs Januvia and others were consolidated in MDL No. 2452 in California federal court. Allegations include that the drug manufacturers failed to warn about the risk of pancreatic cancer and pancreatitis. In November 2015, Judge Anthony J. Battaglia under a motion called summary judgment granted the manufacturers request to dismiss all the cases in the MDL. AT this time 749 cases were pending in the MDL. In September 2016, plaintiffs att Continue reading >>

Merck Programs To Help Those In Need - Product

Merck Programs To Help Those In Need - Product

If you have been prescribed a Merck medicine, you may be eligible for the program if all 3 of the following conditions apply: You are a US resident and have a prescription for a Merck product from a health care provider licensed in the United States.* You do not have insurance or other coverage for your prescription medicine. Some examples of other insurance coverage include private insurance, HMOs, Medicaid, Medicare, state pharmacy assistance programs, veterans assistance, or any other social service agency support. You cannot afford to pay for your medicine. You may qualify for the program if you have a household income of $48,560 or less for individuals, $65,840 or less for couples, or $100,400 or less for a family of 4. At Merck we realize that sometimes exceptions need to be made based on the patient's individual circumstances. If you do not meet the prescription drug coverage criteria, your income meets the program criteria, and there are special circumstances of financial and medical hardship that apply to your situation, you can request that an exception be made for you. * You do not have to be a US citizen. Legal residents of the United States, including US Territories, are also eligible. For income limits in Alaska and Hawaii, please call 1-800-727-5400. If you believe that you meet the eligibility criteria for the Merck Patient Assistance Program and you have received a prescription for a Merck product, call toll-free 1-800-727-5400 8 AM to 8 PM EST to obtain a brochure outlining the program and an enrollment application, or by clicking on the link on the right. After downloading the application or receiving your packet in the mail, follow these simple steps to submit your enrollment form for your free Merck medicines: Complete ALL information on the enroll Continue reading >>

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