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Januvia Effectiveness

Januvia Side Effects

Januvia Side Effects

Januvia is the brand name of the drug sitagliptin, which is used to treat type 2 diabetes. Type 2 diabetes is a disease in which the body doesn't make or use the hormone insulin normally, so it can't properly control your blood sugar levels. Januvia belongs to a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by increasing levels of substances in the body that help lower blood sugar. Januvia may be taken alone or with other diabetes medications. It's often prescribed as a combination medicine called Janumet (which contains the drugs sitagliptin and metformin). Taking Januvia, along with adopting a healthy lifestyle, can reduce your risk of developing serious or life-threatening complications from diabetes, which may include heart disease, stroke, nerve damage, kidney problems, or eye problems. The U.S. Food and Drug Administration (FDA) approved Januvia in 2006. It's manufactured by Merck & Co. Januvia Warnings Januvia shouldn't be taken by people with type 1 diabetes (a disease in which the body doesn't produce any insulin) or diabetic ketoacidosis (a dangerous condition that can occur if high blood sugar is untreated). Before taking Januvia, tell your doctor if you have, or have ever had: Kidney disease Angioedema (swelling of the face, lips, tongue, throat, arms, or legs) Januvia may increase the risk of developing pancreatitis (swelling and inflammation of the pancreas). Be sure to tell your doctor if you've ever had any problems with your pancreas, or if you experience any of the following symptoms while taking Januvia: Severe pain in your upper stomach that spreads to your back Loss of appetite Fast heartbeat Severe nausea and vomiting Also, tell your doctor you're taking this medicine before having any type of surgery, including a dental Continue reading >>

Comparative Real World Effectiveness Of Liraglutide Versus Sitagliptin In Patients With Type 2 Diabetes As An Add-on To Metformin Monotherapy In The United States

Comparative Real World Effectiveness Of Liraglutide Versus Sitagliptin In Patients With Type 2 Diabetes As An Add-on To Metformin Monotherapy In The United States

Abhishek S. Chitnis1*, Michael L. Ganz1, Nicole Benjamin1, Mette Hammer2 and Jakob Langer2 1Evidera, Lexington, MA, USA 2Novo Nordisk Inc., Plainsboro, NJ, USA *Corresponding Author : Abhishek S. Chitnis, M. Pharm, PhD Evidera, 430 Bedford Street Suite 300, Lexington, MA 02420, USA Tel: +1 781-960-0256 E-mail: [email protected] Received August 23, 2014; Accepted October 15, 2014; Published October 22, 2014 Citation: Chitnis AS, Ganz ML, Benjamin N, Hammer M, Langer J (2014) Comparative Real World Effectiveness of Liraglutide versus Sitagliptin in Patients with Type 2 Diabetes as an Add-On to Metformin Monotherapy in the United States. Intern Med S6:007. doi:10.4172/2165-8048.S6-007 Copyright: © 2014 Chitnis AS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Visit for more related articles at Internal Medicine: Open Access Abstract Objective: Limited real-world evidence is available on the effectiveness of liraglutide compared with sitagliptin as an add-on therapy to metformin in clinical practice for adult patients with Type 2 diabetes mellitus (T2DM). The purpose of this study was to compare clinical outcomes 6 months after initiating treatment with liraglutide or sitagliptin for patients uncontrolled on metformin monotherapy in the United States (US). Methods: We used the General Electric Centricity electronic medical records database to analyze the effectiveness of liraglutide and sitagliptin in adult (≥18 years) patients with T2DM who started either drug between January 1, 2010 and January 31, 2013 (index period) as an add-on to metformin monotherapy. Changes Continue reading >>

Comparative Safety And Effectiveness Of Sitagliptin In Patients With Type 2 Diabetes: Retrospective Population Based Cohort Study

Comparative Safety And Effectiveness Of Sitagliptin In Patients With Type 2 Diabetes: Retrospective Population Based Cohort Study

Comparative safety and effectiveness of sitagliptin in patients with type 2 diabetes: retrospective population based cohort study Comparative safety and effectiveness of sitagliptin in patients with type 2 diabetes: retrospective population based cohort study BMJ 2013; 346 doi: (Published 25 April 2013) Cite this as: BMJ 2013;346:f2267 J K Sandhu-Minhas, research associate 2 , 1Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, AB, Canada, T6G 2G3 2Alliance for Canadian Health Outcomes Research in Diabetes, University of Alberta, Edmonton, AB, Canada, T6G 2E1 3Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada, T6G 2B7 4Center for Health Outcomes, University of Illinois College of Medicine at Peoria, Peoria, IL, 61656-1649, USA 5Department of Pharmacy Administration, University of Illinois at Chicago College of Pharmacy, Chicago, IL, 60612-7231, USA 6Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada, T6G 2B7 7Patient Health Outcomes Research and Clinical Effectiveness, University of Alberta, Edmonton, AB, Canada, T6G 2B7 Correspondence to: D T Eurich 2-040 Li Ka Shing Center for Health Research Innovation, University of Alberta, Edmonton, AB, Canada, T6G 2E1 deurich{at}ualberta.ca Objective To determine if the use of sitagliptin in newly treated patients with type 2 diabetes is associated with any changes in clinical outcomes. Design Retrospective population based cohort study. Setting Large national commercially insured US claims and integrated laboratory database. Participants Inception cohort of new users of oral antidiabetic drugs between 2004 and 2009 followed until death, termination of medical insurance, or December 31 2010. Continue reading >>

Merck's Januvia Effective In Combination Studies

Merck's Januvia Effective In Combination Studies

Merck's Januvia effective in combination studies * Januvia plus Actos superior to Actos alone * 60 pct of patients reach blood sugar goal vs 28 pct NEW YORK, June 6 (Reuters) - Merck & Co Incs ( MRK.N ) fast growing diabetes drug Januvia proved effective in helping patients lower blood sugar in combination with Takedas Actos, and when used along with insulin therapy, according to data from a pair of clinical trials. In a 497-patient, 24-week study, treatment with Januvia plus Actos as an initial therapy resulted in a 2.4 percent reduction in A1C level compared with a 1.5 percent reduction for patients taking the Takeda Pharmaceutical Co Ltd ( 4502.T ) drug alone, Merck said. The difference was considered to be statistically significant. A1C is a key measure of a persons average blood glucose level over a two- to three-month period. The American Diabetes Association (ADA) guidelines call for A1C levels of 7 percent or less. Type 2 diabetes patients began the trial with A1C levels of 8 percent to 12 percent. Sixty percent of those who received the combination therapy achieved an A1C of less than 7 percent, compared with 28 percent of patients who only took Actos, known chemically as pioglitazone, according to data presented on Saturday at the annual ADA scientific meeting in New Orleans. Januvia, known chemically as sitagliptin, belongs to a new class of diabetes medicines called DPP-4 inhibitors. Actos belongs to the older, widely used thiazolidinedione, or TZD, class of drugs for the growing type 2 diabetes epidemic. Over time most type 2 diabetes patients require multiple drugs to achieve glycemic control, said John Amatruda, Mercks head of diabetes and obesity and one of the studys authors. Amatruda said these studies should show doctors that getting patients to goal Continue reading >>

Januvia And Janumet

Januvia And Janumet

Januvia (sitagliptin) is an oral Type 2 diabetes medication manufactured by Merck & Co. The U.S. Food and Drug Administration (FDA) approved the drug in 2006, and it is one of the most popular Type 2 diabetes drugs on the market. In 2007, the FDA approved a variation of Januvia called Janumet, which is a combination of sitagliptin and metformin. Janumet also comes in an extended-release formula called Janumet XR. Januvia and Janumet are known as dipeptidyl peptidase 4 (DPP-4) inhibitors that work by helping the body produce more insulin. Both Januvia and Janumet belong to a class of drugs called dipeptidyl peptidase 4 (DPP-4) inhibitors that work by helping the body produce more insulin. Januvia was the first DPP-4 approved by the FDA and is the top-selling brand in its class. Two million prescriptions were written for Januvia in 2011. Januvia brought in about $6 billion in 2014. Merck stands to benefit from the patent on the drug until 2022. In clinical trials, Januvia proved effective in controlling blood-sugar levels. However, some studies reported rare and serious side effects, including acute pancreatitis, severe joint pain, pancreatic cancer and thyroid cancer. How Do Januvia and Janumet Work? Januvia is designed to work with other Type 2 diabetes medications, like Byetta, to increase their effectiveness. It helps lower blood sugar in two ways. It helps the body increase insulin to stabilize blood sugar and decrease sugars that are made in the liver. It is a part of the class of diabetes medications called DPP-4 inhibitors. DPP-4 is a protein made by the body that plays a role in glucose metabolism. The process works like this: After a person eats and blood sugar rises, intestinal cells release hormones called incretin hormones. Incretin stimulates pancreatic cell Continue reading >>

Effectiveness Of Sitagliptin For Hiv Insulin Resistance And Inflammation

Effectiveness Of Sitagliptin For Hiv Insulin Resistance And Inflammation

You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effectiveness of Sitagliptin for HIV Insulin Resistance and Inflammation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. ClinicalTrials.gov Identifier: NCT01552694 Information provided by (Responsible Party): Kevin Yarasheski, PhD, Washington University School of Medicine Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information People living with human immunodeficiency virus infection (HIV) have 2-4fold greater risk for developing diabetes and heart disease than the general population. They need safe and effective treatments that reduce the risk for developing diabetes and heart disease, and improve their quality of life. This project will explore whether a new anti-diabetes medication (Januvia) with a novel mechanism of action reduces inflammation, and improves blood vessel function in HIV infected men and women with several risk factors for developing cardiovascular disease. Inflammation Macrophage Infiltration Cardiovascular Disease People living with human immunodeficiency virus (HIV+) infection have a 2-fold greater prevalence and incidence of T2DM and cardiovascular disease (CVD) than the general population. The investigators lack safe and effective treatments for these HIV related cardiometabolic complications despite the fact that HIV infected adults represent an ideal clinical population in which to study interactions among chronic low-grade pro-inflammatory processes that are linked to the develop Continue reading >>

Lowers Your Blood Sugar.

Lowers Your Blood Sugar.

Our bottom line Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine. Oral blood sugar-lowering medicine. Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class. It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines. Lowers A1c (average blood sugar over time) by less than 1%. Rare but serious side effects include pancreatitis and severe joint pain. Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin. Sign up and get Pill Talk, the latest in health & medicine news from Iodine What to expect when you take Januvia (sitagliptin) for Type 2 diabetes Possible side effects Source: FDA product label and Iodine pharmacists Side effect rates for Januvia (sitagliptin) Where we got our data » Risks and Warnings for Januvia (sitagliptin) Higher risk if: › History of pancreatitis › High blood triglyceride levels › Gallstones (stones in gallbladder) › History of alchoholism › Kidney problems Januvia (sitagliptin) can cause a sudden inflammation of the pancreas. This can be life-threatening if not treated. Let your doctor know about any stomach pain, nausea, vomiting, or loss of appetite that doesn't go away. Frequently Asked Questions This medication treats type 2 diabetes in adults. Common concerns from people taking Januvia (sitagliptin) Take once a day in the morning with or without food. Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function. Tell your doctor right away if you have severe stomach pain, Continue reading >>

What Patients Say About Janumet 50 1000

What Patients Say About Janumet 50 1000

Janumet 50 1000 is the brand name (and dosage level) of sitagliptin-metformin, a combination prescription drug used in the management of type 2 diabetes. (50 refers to 50 mg of sitagliptin while 1000 refers to 1000 mg of metformin.) In addition to diet and exercise, Janumet 50 1000 is prescribed when the use of metformin or sitagliptin alone does not adequately control the condition. At PatientsLikeMe, where more than 130,000 patients are sharing their experiences with conditions, symptoms, treatments and more, 21 patients report using Janumet 50 1000 or a lower daily dosage (50 mg sitagliptin / 500 mg metformin). What can we learn from these patients’ experiences? Quite a bit, actually, thanks to PatientsLikeMe’s unique data-sharing platform. Looking at the three treatment evaluations submitted for Janumet, all three patients rate the effectiveness as “Moderate,” while side effects were marked as “Mild,” “Moderate” and “Severe,” respectively. The chief complaint from the patient who reported “Severe” side effects was diarrhea. However, she writes, “Blood sugars are going down.” JOIN PATIENTSLIKEME TODAY What about you? Have you taken Janumet 50 1000 or a different dosage of this combination diabetes medication? Join PatientsLikeMe and add your experiences to our growing body of knowledge. Then, stay to exchange advice and support, research common treatments and learn from other patients like you. Continue reading >>

The Effectiveness Of Combination Treatment With Insulin And Sitagliptin In T2 Patients

The Effectiveness Of Combination Treatment With Insulin And Sitagliptin In T2 Patients

Patients on therapy may see increased reduction in HbA1c, lower BP, lower lipid values…. Dipeptidyl peptidase-4 (DPP-4) inhibitors are used for the treatment of type 2 diabetes. Sitagliptin was the first medication approved for people with type 2 diabetes who are taking insulin. There are not a lot of studies that have investigated the use of DPP-4 and insulin therapy in patients with long-term diabetes diagnosis. Currently, there aren’t any studies that have evaluated the efficiency of DPP-4 inhibitors in activating insulin feedback in patients with minimal insulin secretion who are on insulin therapy. Researchers evaluated the effectiveness and safety of insulin-sitagliptin combination treatment to establish the benefit of this regimen in patients with type 2 diabetes. The study design was a multicenter retrospective study from November 2011 to March 2013. The study was conducted in 36 diabetes clinic in Kanagawa Prefecture, Japan. Patients who were eligible were on insulin 6 months prior and on sitagliptin if their HbA1c was 7.0% or higher with insulin therapy. The primary endpoint was the variation in HbA1c levels. The results from this study were reported as mean + standard deviation. Other endpoints in this study were weight, blood pressure values, total cholesterol, and triglycerides. The study included 1,169 patients. The results showed that most patients (n=809) received sitagliptin 50mg. In 1,004 patients, HbA1c was reduced by 0.74% and body weight was increased by 0.1kg after 6 months of combination treatment of insulin and sitagliptin. In this study, hypoglycemic events occurred in 7.4% of the patient population, however none of the events were severe. Also, a multiple regression analysis on 114 patients showed that C-peptide had no effect on the effecti Continue reading >>

How Does Januvia Work In Your Body?

How Does Januvia Work In Your Body?

JANUVIA (jah-NEW-vee-ah) is a once-daily prescription pill that, along with diet and exercise, helps lower blood sugar levels in adults with type 2 diabetes. JANUVIA should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUVIA. Serious side effects can happen in people who take JANUVIA, including pancreatitis, which may be severe and lead to death. Before you start taking JANUVIA, tell your doctor if you've ever had pancreatitis. Stop taking JANUVIA and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis. Before you start taking JANUVIA, tell your doctor if you have ever had heart failure (your heart does not pump blood well enough) or have problems with your kidneys. Contact your doctor right away if you have increasing shortness of breath or trouble breathing (especially when you lie down); swelling or fluid retention (especially in the feet, ankles, or legs); an unusually fast increase in weight; or unusual tiredness. These may be symptoms of heart failure. Do not take JANUVIA if you are allergic to any of its ingredients, including sitagliptin. Symptoms of serious allergic reactions to JANUVIA, including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing, can occur. If you have any symptoms of a serious allergic reaction, stop taking JANUVIA and call your doctor right away. Kidney problems, somet Continue reading >>

Januvia Oral Reviews And User Ratings: Effectiveness, Ease Of Use, And Satisfaction

Januvia Oral Reviews And User Ratings: Effectiveness, Ease Of Use, And Satisfaction

This drug almost killed me! My entire body was numb and tingling for 3 months. I was in ER twice, admitted once ,had thousands of dollars in test and I am happy they were all normal.Once I stopped the drug it took 3 months for the symptom's to stop and co away!I did report this to the drug company. This drug almost killed me! My entire body was numb and tingling for 3 months. I was in ER twice, admitted once ,had thousands of dollars in test and I am happy they were all normal.Once I stopped the drug it took 3 months for the symptom's to stop and co away!I did report this to the drug company. I started out on metaformin once a day, then went to twice a day, levels and A1C started going up again, then add Januvia seemed to help at first then I stared gaining weight and sugar levels and A1C started going up again, added trilicity shots once a week seemed to be doing ok, now the levels and A1C are climbing again. I stopped the Januvia because of the joint pain I was having and the sugar c ... Show Full Comment I started out on metaformin once a day, then went to twice a day, levels and A1C started going up again, then add Januvia seemed to help at first then I stared gaining weight and sugar levels and A1C started going up again, added trilicity shots once a week seemed to be doing ok, now the levels and A1C are climbing again. I stopped the Januvia because of the joint pain I was having and the sugar cravings. Been off it about a month and my levels are not any better so heading to the DR again to see what to try next. I think diabetes drugs are a joke the are not made to help for a long time before you have to add another pill or shot to keep things working. Big pharm making some money off from these for sure. I started Januvia 100 mg twice a day with Metformin 1000mg. Continue reading >>

Sitagliptin Is Safe And Effective For Asian Type 2 Diabetes Patients

Sitagliptin Is Safe And Effective For Asian Type 2 Diabetes Patients

This study examined the safety and effectiveness of the addition of sitagliptin (Januvia) to insulin therapy in Asian type 2 diabetes patients. Type 2 diabetes is a progressive disease. While blood glucose (sugar) levels can often first be controlled with diet and exercise alone, patients will need to add glucose-lowering medications and, eventually, insulin therapy. However, insulin therapy can increase the risk of hypoglycemia (dangerously low blood glucose). Dipeptidyl peptidase-4 (DPP-4) inhibitors, such as sitagliptin, increase the amount of insulin produced by the body in response to glucose. DPP-4 inhibitors can improve blood glucose control without increasing the risk of hypoglycemia. However, many of the studies examining DPP-4 inhibitors have been carried out on Caucasion patients. DPP-4 inhibitors such as sitagliptin can lead to larger decreases in glucose in Asian type 2 diabetes patients. Therefore, the safety and effectiveness of sitagliptin needs to be examined in this population. This study examined the safety and effectiveness of adding sitagliptinin Asian type 2 diabetes patients whose blood glucose was not controlled by insulin alone. In this study, 49 patients were randomly assigned to receive insulin plus sitagliptin (Group 1; 25 patients) or insulin alone (Group 2; 24 patients) for 24 weeks. The difference in HbA1c (average blood glucose over 3 months) and post-meal glucose levels (glucose levels measured at certain times prior to and following a meal) were measured at the start of the study (baseline) and at 24 weeks. Average HbA1c decreased significantly, from 7.9% at baseline to 7.0% at 24 weeks, in Group 1. HbA1c did not change in Group 2. At 24 weeks, average HbA1c levels were 0.9% lower in patients in Group 1 compared to patients in Group 2. Continue reading >>

Effectiveness Of Januvia (sitagliptin)

Effectiveness Of Januvia (sitagliptin)

Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community DavidGrahamJones Type 2 Well-Known Member I've been taking Januvia for 3 weeks now as my body is quite happy to go without carbs (40gms per day) and must be using fat and protein. I had a ketosis blood test some time ago which showed that my body was in ketosis and I should have been burning fat (in theory). Although my shape change my weight didn't. Since taking Januvia I have observed that my BG is even worse and even more all over the place, I only have to put food (non carb) in my mouth and up it goes. It's almost as if my insulin resistance has worsened, but until I can get a private test organised, I'll not know. I have often heard people mention that Metformin doesn't do much, has anyone found that Januvia isn't so good either. I realise we will all have different experiences, just interested in the experience of others. Thank you for that. I took the decision not to read up on side effects for the first two weeks so as not to affect the way I felt. I initially felt awful and I kept a note of what I was feeling. They were all on the side effects in my BNF. I now think I've given it a fair crack of the whip. I'm not sure what's next, Gliclazide? Seems to be like cracking a nut with a sledge hammer as before Januvia I could manage several hours with a BG of 6 - 7, with Januvia it's always in double figures and never after a meal, but 6 or 7 hours later. Thank you for that. I took the decision not to read up on side effects for the first two weeks so as not to affect the way I felt. I initially felt awful and I kept a note of what I was feeling. They were all on the side effects in my BNF. I now think I've given it a fair crack of the whip. I'm no Continue reading >>

Yet Another Problem With Januvia

Yet Another Problem With Januvia

UPDATE (April 2, 2013): Before you take Byetta, Victoza, Onglyza, or Januvia please read about the new research that shows that they, and probably all incretin drugs, cause severely abnormal cell growth in the pancreas and precancerous tumors. You'll find that information HERE. Update (January, 2009) : A much more important problem with Januvia--that it promotes cancer by inhibiting a tumor suppressor gene researchers have called "the trigger for prostate cancer"--is discussed in this more recent blog post: More Research Shows Januvia and Glinides Inhibit Tumor Suppressor Gene DPP-4. Posted Dec 8, 2008. Original Post: If you have had or might get melanoma, ovarian cancer, lung cancer or prostate cancer, please read the above post before making your decision about whether Januvia is for you. Here is the original post that was posted 9/12/08: I have been hearing from people about a new, and, to me, very troubling problem with Januvia. The problem is this: now that doctors have decided that all people recently diagnosed with Type 2 Diabetes should be put on Januvia, prescriptions for the combination drug Janumet, which is made up of both Januvia and Metformin, are becoming much more frequent as a first prescription for diabetes. Metformin is a very safe drug that has been used safely for decades. The most recent follow up to the UKPDS study, the 20 year follow-up, which was just presented at the annual EASD conference found that at 20 years after the start of the study, "Patients treated with metformin had a 21% reduction in risk of any diabetes endpoint (P=0.01), a 30% reduction in risk of diabetes-related death (P=0.01), a 33% reduction in risk of MI (P=0.005), and a 27% reduction in risk of all cause mortality (P=0.002)." Metformin is a very good drug for people with Ty Continue reading >>

Januvia

Januvia

I'm maxed out on metformin (850 mg 3x/day) and glyburide (5mg 4x/day). Januvia, even without the other 2 meds, had my readings in the desired ranges in a day. It's only been 5 days, but so far VERY GOOD! Thanks! Started Januvia 100 mg once a day with in days I had joint pain so bad I did not want to get out of bed and the join pain has not went away its not as bad but still there. Chronic heart pain my heart beat so hard and fast I worried I was having a heart attack. My chest was/is sore I have congestion, I still have a fast heart beat off and on "This worries me". Shortness of breath. I was dizzy, chest colds, Very bad headache, Both hands were numb this was worse at night I would wake with my hands hurting I still have some numbness it is off and on and and mostly in my fingers now. I was so hoping Januvia would work for me. I do not think this drug was not tested well enough before the public was allowed to use it. I hope my side effects are not long term and no damage was caused and with time will go away. I was on another medication for type 2 diabetes and it didnot work for me. My doctor didn't want to take me off of it because he said it work for most people. Well, I change Doctors and the new Doctor stated me on Januvia 50 mg in the AM and 50 in the PM and it started to work at the end of the week, no side effects, my number was very close to normal and I feel GREAT . I even lost weight while on this medication. My husband is on 50 mg a day and doing great with no side effects. Family member had a rash with this medicine, and a friend said there was a new warning posted about a deadly disease called Stevens-Johnson syndrome associated with Januvia. I didn't find it in WebMd though. Is it true? Januvia (with metformin) has worked very well for me so far (3 mont Continue reading >>

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