Januvia Alcohol

Non-alcoholic Fatty Liver Disease And Diabetes

Abstract Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM) are common conditions that regularly co-exist and can act synergistically to drive adverse outcomes. The presence of both NAFLD and T2DM increases the likelihood of the development of complications of diabetes (including both macro- and micro- vascular complications) as well as augmenting the risk of more severe NAFLD, including cirrhosis, hepatocellular carcinoma and death. The mainstay of NAFLD management is currently to reduce modifiable metabolic risk. Achieving good glycaemic control and optimising weight loss are pivotal to restricting disease progression. Once cirrhosis has developed, it is necessary to screen for complications and minimise the risk of hepatic decompensation. Therapeutic disease modifying options for patients with NAFLD are currently limited. When diabetes and NAFLD co-exist, there are published data that can help inform the clinician as to the most appropriate oral hypoglycaemic agent or injectable therapy that may improve NAFLD, however most of these data are drawn from observations in retrospective series and there is a paucity of well-designed randomised double blind placebo controlled studies with gold-standard end-points. Furthermore, given the heterogeneity of inclusion criteria and primary outcomes, as well as duration of follow-up, it is difficult to draw robust conclusions that are applicable across the entire spectrum of NAFLD and diabetes. In this review, we have summarised and critically evaluated the available data, with the aim of helping to inform the reader as to the most pertinent issues when managing patients with co-existent NAFLD and T2DM. Continue reading >>

Wine Protects Against Diabetes?

Study suggests wine consumption offers greater protection against type 2 risk, compared with beer or other alcoholic beverages. In a study published in Journal of Diabetes Investigation, researchers concluded that any amount of wine — with certain precautions — can have a positive effect for type 2 diabetes. The pooled RRs for different alcoholic beverages indicated that all wine, beer or spirits consumption was associated with decreased risk of type 2 diabetes, according to the researchers. “In spite of the similarity, there were still diversities among different types of alcoholic beverages.” Wine consumption yielded a 15% reduced risk for type 2 diabetes, beer consumption yielded a slight decrease in the risk and spirit consumption yielded a slight reduction, although not significant. In an additional analysis for amount of consumption (low, 0-10 g/day; moderate, 10-20 g/day; high, > 20 g/day), any amount of wine was linked to a significant decreased risk for type 2 diabetes. Moderate beer consumption had a greater effect for reducing the risk for type 2 diabetes compared with the low consumption, but there was no decreased risk with beer consumption in the high category. There was a mild decreased risk for type 2 diabetes with low and moderate spirits consumption, whereas high consumption was linked to an increased risk. “The present meta-analysis demonstrates strong evidence that specific alcoholic beverages had different effects on reducing the risk of type 2 diabetes,” the researchers wrote. “Wine consumption was associated with a significant reduction [in] risk of type 2 diabetes, while beer or spirits consumption showed a slight decrease in the risk of type 2 diabetes. The study provides a new perspective to explore the association between alcohol Continue reading >>

Metformin And Sitagliptin

Pronunciation: met FOR min and SI ta glip tin Brand: Janumet, Janumet XR Janumet 100 mg-50 mg What is the most important information I should know about metformin and sitagliptin? You should not use this medicine if you have severe kidney disease or diabetic ketoacidosis (call your doctor for treatment with insulin). This medicine may cause a serious condition called lactic acidosis. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired. What is metformin and sitagliptin? Metformin and sitagliptin are oral diabetes medicines that help control blood sugar levels. Metformin works by decreasing glucose (sugar) production in the liver and decreasing absorption of glucose by the intestines. Sitagliptin works by regulating the levels of insulin your body produces after eating. Metformin and sitagliptin is a combination medicine that is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. This medicine is not for treating type 1 diabetes. Metformin and sitagliptin may also be used for purposes not listed in this medication guide. What should I discuss with my health care provider before taking metformin and sitagliptin? You should not use this medicine if you are allergic to metformin or sitagliptin (Januvia), or if you have severe kidney disease or diabetic ketoacidosis (call your doctor for treatment with insulin). Some people taking metformin develop a serious condition called lactic acidosis. This may be more likely if you have liver or kidney disease, congestive heart failure, a heart attack or stroke, a severe infe Continue reading >>

Drug Interactions With Alcohol, Usp Top And Sitagliptin Oral

alcohol, usp top brand names and other generic formulations include: Antiseptic Bio-Hand Top, Antiseptic Gel Top, BODI Line HAND SANITIZER Top, Derma Stat Top, Dermagel Hand Sanitizer Top, Epi-Clenz Top, ethyl alcohol (skin cleanser) Top, Gelrite Hand Sanitizer Top, GEL-STAT Top, Hand Sanitizer Top, Hand Sanitizing Wipes Top, HurriSept Antiseptic Top, Instant Hand Sanitizer Top, Isagel No Rinse Top, Prevacare Antimicrobial Top, Purell Purifying Essential Top, Purell Top, Renewal Hand Sanitizer Top, Rubbing Alcohol (ethanol) Top, Sanix Top, Triseptin Top sitagliptin oral brand names and other generic formulations include: Januvia Oral Continue reading >>

Can You Take Metformin And Januvia Together

What type of drug is Metformin Metformin is a Generic name for a drug with antihyperglycemic properties that is used for treating non – insulin – dependent diabetes mellitus. This drug can improve glucose levels in blood by decreasing the production of glucose in liver, decreasing intestinal absorption of glucose and increasing insulin-mediated glucose uptake. Therapy with metformin may also decrease the risk of having a stroke, heart attack, or other diabetes-related complications. Metformin can induce weight loss and that’s why it is the drug of choice for obese patients with diabetes type two. When it is used alone, this drug doesn’t cause hypoglycemia as side effect; but, it may potentiate the hypoglycemic effects of sulfonylureas drugs and insulin if they are used together. Metformin is available in the form of tablet in following dosage forms: 500, 750, 850 and 1000 mg. It is usually taken during meals. Common Brand names on the market containing metformin as an active ingredient are: Glucophage, Glumetza, Glucophage XR, Fortamet, Metformin Sandoz, Diabex, Diaformin, Siofor, Metfogamma and Riomet. What is Januvia Januvia is a Brand name for a drug containing sitagliptin as an active ingredient. It is an oral diabetes drug that is used to control sugar levels in blood. Januvia works by regulating insulin levels that body produces after eating. This drug is used for the treatment of patints with type 2 diabetes. Januvia can be used in combination with other diabetes medicines, but is not used for treating type 1- diabetes. Patients with diabetic ketoacidosis should not use Januvia. Januvia is available in tablet and film-coated tablet form in following strenghts: 25, 50 and 100 mg. Common Brand names on the market containing sitagliptin as an active ingredie Continue reading >>

Dpp-iv Inhibitors

Inhibits the degradation of incretins such as GLP-1 by inhibiting the enzyme dipeptidyl peptidase IV (DPP-IV). The incretin effect is prolonged, enhancing glycemic control through various mechanisms, primarily by stimulating insulin synthesis and secretion in a glucose-dependant manner and by reducing glucagon secretion. brand name preparation manufacturer route form dosage^ cost* Januvia sitagliptin phosphate Merck oral tablet 25 mg $885 for 90 tabs oral tablet 50 mg $885 for 90 tabs oral tablet 100 mg $295 for 30 tabs Onglyza saxagliptin Bristol-Myers Squibb oral tablet 2.5 mg $295 for 30 tabs oral tablet 5 mg $885 for 90 tabs Tradjenta linagliptin Eli Lilly oral tablet 5 mg $870 for 90 tabs Janumet sitagliptin phosphate + metformin hydrochloride Merck Sharp & Dohme Corp. oral tablet 50/500 mg $885 for 180 tabs oral tablet 50/1000 mg $885 for 180 tabs Nesina alogliptin Takeda oral tablet 6.25 mg $374 for 30 tabs oral tablet 12.5 mg $374 for 30 tabs oral tablet 25 mg $374 for 30 tabs **Patient Assistant Programs: ** Information gathered by Heather Tran and Gladimir Elysee *Prices represent cost per unit specified, are representative of "Average Wholesale Price" (AWP). ^Dosage is indicated in mg unless otherwise noted. Continue reading >>

Janumet (metformin, Sitagliptin)

What is Janumet used for? Janumet tablets are licensed for use in people with type 2 diabetes whose blood sugar is not controlled by the maximum tolerated dose of metformin alone, or who are already taking metformin and sitagliptin as separate tablets. They are also licensed for use in combination with a sulphonylurea (eg gliclazide) or a glitazone (eg pioglitazone), when one of these combined with metformin has not controlled blood sugar well enough. Janumet tablets may also be used in combination with insulin. How does Janumet work? Janumet tablets contain two active ingredients, metformin and sitagliptin. Metformin is a type of antidiabetic medicine known as a biguanide. It works in a number of ways to decrease the amount of sugar in the blood. Firstly, it reduces the amount of sugar produced by cells in the liver. Secondly, it increases the sensitivity of muscle cells to insulin. This enables these cells to remove sugar from the blood more effectively. Finally, it also delays absorption of sugar from the intestines into the bloodstream after eating. Sitagliptin is a type of antidiabetic medicine known as a dipeptidyl peptidase-4 (DPP-4) inhibitor. It helps to reduce blood sugar levels by preventing the breakdown of two incretin hormones, called glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). These hormones are normally produced naturally by the body in response to food intake. They stimulate the pancreas to produce insulin in response to increasing levels of glucose in the blood, and they also reduce the production of glucagon, which is a hormone that normally increases glucose production by the liver. These actions help control blood sugar levels. This combination of medicines helps control blood sugar levels both directly after Continue reading >>

Alcohol And Diabetes

Though moderate alcohol consumption can have some health benefits, excessive alcohol use can lead to many health conditions or worsen complications that patients already face. Consuming alcohol is not a wise choice for everyone. There are some health conditions and medications that are not compatible with alcohol. Normally, people with diabetes can safely consume moderate amounts of alcohol under certain conditions. Diabetes patients should consume alcohol only when: Their diabetes is under control They are aware of how alcohol can affect them and their diabetes Their physician has decided it is safe for their particular situation They have eaten before drinking alcohol A patient should not exceed the recommended guideline of one drink per day for a woman and two drinks per day for a man. One drink is defined as: One 12 ounce (355 milliliter [ml]) bottle of beer or wine cooler One 5 ounce (148 ml) glass of wine 1.5 ounces (44 ml) of 80–proof distilled spirits. Patients who decide to consume alcohol must prepare themselves and the people around them for the risk of hypoglycemia (low blood glucose). This risk is greatest for people taking insulin or anti-diabetic agents. The risk of hypoglycemia is significantly less in people with type 2 diabetes who control it with exercise and meal planning alone. Patients trying to control their weight will also have to incorporate the additional calories from the alcohol into their meal plan. About alcohol & diabetes Many people do not think of alcohol as a drug. However, alcohol is a drug that affects the body in various ways, depending on the dose. Blood alcohol concentration (BAC) is the amount of alcohol present in a person’s bloodstream. It is determined by the speed of consumption as well as the drinker’s gender, weight, Continue reading >>

Can You Drink Alcohol While Taking Metformin?

Metformin is a medication that helps manage type 2 diabetes and occasionally prediabetes. In general, drinking alcohol while taking metformin is not helpful and not recommended by doctors. The side effects of metformin can be life-threatening with excessive alcohol consumption. Metformin and alcohol both put stress on the liver, so intensifying the harmful effects and increasing the risk of liver complications. How does metformin and alcohol affect the body? Metformin is a popular, effective, and inexpensive management medication, prescribed for the treatment of type 2 diabetes. In 2014, some 14.4 million people in the United States were prescribed metformin. Metformin is also being used more and more frequently in prediabetes cases. Metformin use in overweight people with type 1 diabetes may also reduce insulin requirements and increase metabolic control. The drug works by improving insulin sensitivity, promoting the uptake of glucose into tissues and lowering sugar levels in the bloodstream. By increasing how effectively the existing glucose is used, metformin reduces the amount of glucose the liver produces and the intestines absorb. Alcohol also affects blood sugars significantly. Alcohol digestion puts stress on the liver, an organ dedicated to the removal of poisons from the body. When the liver is forced to process high amounts of alcohol, it becomes overworked and releases less glucose. Long-term alcohol use can also make cells less sensitive to insulin. This means that less glucose is absorbed from the blood and levels in the bloodstream increase. Over time, alcohol consumption damages the liver, especially when it is consumed in excess. It reduces the liver's ability to produce and regulate glucose. Conditions like alcoholic hepatitis and cirrhosis of the live Continue reading >>

Januvia And Alcohol Interaction

Januvia generic name sitagliptin belongs to the family of oral diabetes medicines that help control blood sugar levels and works by regulating the levels of insulin your body produces after eating. It is used to treat people with type 2 diabetes which is non-insulin-dependent diabetes and is sometimes used in combination with other diabetes medications. It is not used for treating type 1 diabetes. It is suggested that only moderate alcohol consumption be considered as alcohol will greatly increase the side effects. Do not use this drug if you are allergic to Januvia or are in a state of diabetic ketoacidosis. At this time the medical community defines moderate consumption of alcohol as no more than two drinks per day and no more than 14 drinks per week. Anything more than that is considered an unhealthy dependency on alcohol that may have adverse social, family and health consequences. If a person drinks only once or twice a week but drinks on the same days each week and more than two drinks this is considered as an alcohol dependency. If a person binge drinks at any time during the week this is also considered as alcoholism. Some consider alcoholism as a disease while others consider it an addiction which is the result of personal choice and character fault. This school of thought blames the alcoholism on life style choices. Personally I consider alcoholism a genetic tendency as I have seen families of alcoholics even when they live far apart. These unfortunate people are probably dependent on alcohol from the first drink. When alcohol interacts with prescription over the counter drugs it usually results in negative health effects most especially liver damage as the main organ affected. It is suggested that before taking this or any other drug you have a frank and hone Continue reading >>

Why Trulicity Could Be A Truly Dreadful Diabetes Drug

This is certainly turning out to be a bumper year for new diabetes drugs, which seem to be getting approved at an unprecedented rate. The latest one is called Trulicity, a once-a-week injection from Eli Lilly and Co, which has been fast-tracked onto both the American and European markets, despite serious concerns over its safety. Trulicity sounds like a character from a Julie Andrews musical and your brain will unconsciously associate the name with truth, simplicity and felicity (happiness). But a spoonful of sugar won’t make this very nasty medicine go down. It comes with an FDA ‘black box’ warning about its risks of medullary thyroid cancer and other thyroid tumours, while very similar drugs have previously been linked with acute pancreatitis and pancreatic cancer. Trulicity’s generic name is dulaglutide and it belongs to a class of drugs called GLP-1 receptor agonists that already includes exenatide (Byetta), liraglutide (Victoza) and albiglutide (Tanzeum). Also known as ‘incretin mimics’ – synthetic versions of a natural body chemical that inhibits the release of glucose from your liver into your blood stream – they work in the same way as another closely-related group of drugs called DPP-4 inhibitors. All of these drugs have a history of adverse side effects and serious health risks. As I wrote here, people taking Byetta or the DPP-4 inhibitor sitagliptin (Januvia) are twice as likely as those taking other kinds of diabetes medication to find themselves in hospital with acute pancreatitis, a condition that can lead to deadly pancreatic cancer. Tanzeum comes with warnings of thyroid C-cell tumours, acute pancreatitis and kidney damage, while Victoza also carries a warning of pancreatitis and has been associated with an increased risk of thyroid tumou Continue reading >>

Janumet Xr

JANUMET tablets contain 2 prescription medicines: sitagliptin (JANUVIA®) and metformin. Once-daily prescription JANUMET XR tablets contain sitagliptin (the medicine in JANUVIA®) and extended-release metformin. JANUMET or JANUMET XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. JANUMET or JANUMET XR should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUMET or JANUMET XR. Metformin, one of the medicines in JANUMET and JANUMET XR, can cause a rare but serious side effect called lactic acidosis (a buildup of lactic acid in the blood), which can cause death. Lactic acidosis is a medical emergency that must be treated in a hospital. Call your doctor right away if you get any of the following symptoms, which could be signs of lactic acidosis: feel cold in your hands or feet; feel dizzy or lightheaded; have a slow or irregular heartbeat; feel very weak or tired; have unusual (not normal) muscle pain; have trouble breathing; feel sleepy or drowsy; have stomach pains, nausea, or vomiting. Most people who have had lactic acidosis with metformin have other things that, combined with the metformin, led to the lactic acidosis. Tell your doctor if you have any of the following, because you have a higher chance of getting lactic acidosis with JANUMET or JANUMET XR if you: have severe kidney problems or your kidneys are affected by certain x-ray tests that use injectable dye; have liver problems; drink alcohol very often, or drink a lot of alcohol in short-term “binge” drinking; get dehydrated (lose large amounts of body fluids, w Continue reading >>

Januvia Side Effects

What should I watch for? Visit your doctor or health care professional for regular checks on your progress. A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months. Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them. Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once. Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine. Do not skip meals. Ask your doctor or health care professional if you should avoid alcohol. Many nonprescription cough and cold products contain sugar or alcohol. These can affect blood sugar. Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times. Common and Rare Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Less common blurred vision chills confusion cool, pale skin dizziness fast heartbeat headache increased hunger loss of consciousness nightmares seizures shakiness slurred speech unusual tiredness or weakness Incidence not known Continue reading >>

What Is Januvia®?

JANUVIA (jah-NEW-vee-ah) is a once-daily prescription pill that, along with diet and exercise, helps lower blood sugar levels in adults with type 2 diabetes. JANUVIA should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUVIA. IMPORTANT SAFETY INFORMATION Serious side effects can happen in people who take JANUVIA, including pancreatitis, which may be severe and lead to death. Before you start taking JANUVIA, tell your doctor if you've ever had pancreatitis. Stop taking JANUVIA and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis. Before you start taking JANUVIA, tell your doctor if you have ever had heart failure (your heart does not pump blood well enough) or have problems with your kidneys. Contact your doctor right away if you have increasing shortness of breath or trouble breathing (especially when you lie down); swelling or fluid retention (especially in the feet, ankles, or legs); an unusually fast increase in weight; or unusual tiredness. These may be symptoms of heart failure. Do not take JANUVIA if you are allergic to any of its ingredients, including sitagliptin. Symptoms of serious allergic reactions to JANUVIA, including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing, can occur. If you have any symptoms of a serious allergic reaction, stop taking JANUVIA and call your doctor right Continue reading >>

Januvia

Januvia is a prescription medication used to lower blood sugar levels in adult patients with type 2 diabetes. Januvia belongs to a group of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors, which help lower blood sugar levels in two ways. It helps the body increase insulin to stabilize blood sugar and decrease sugars that are made in the liver. This medication comes in tablet form and is taken once a day, with or without food. Common side effects include upper respiratory infection, stuffy nose, sore throat, nausea, and diarrhea. Januvia is a prescription medicine used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information. Pancreatitis. Serious side effects have occurred with Januvia use including inflammation of the pancreas (pancreatitis) which may be severe and lead to death. Stop taking Januvia and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. Low blood sugar (hypoglycemia). If you take Januvia with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin, your risk of getting low blood sugar is higher. The dose of your sulfonylurea medicine or insulin may need to be lowered while you use Januvia. Signs and symptoms of low blood sugar may include: headache drowsiness weakness dizziness confusion irritability hunger fast heart beat sweating feeling jittery Serious allergic reactions. If you have any symptoms of a serious allergic reaction, stop taking Januvia and call your doctor right away. Your doctor may give you a medicine for y Continue reading >>