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Januvia

Januvia Side Effects

Januvia Side Effects

What is Januvia? Januvia (sitagliptin) is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating. Januvia is for treating people with type 2 diabetes. Januvia is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes. Important information You should not use Januvia if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). Before taking this medicine You should not use Januvia if you are allergic to sitagliptin, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). To make sure Januvia is safe for you, tell your doctor if you have ever had: kidney disease (or if you are on dialysis); heart problems; pancreatitis; high triglycerides (a type of fat in the blood); gallstones; or a history of alcoholism. Januvia is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Your name may need to be listed on a Januvia pregnancy registry when you start using this medicine. It is not known whether sitagliptin passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. Januvia is not approved for use by anyone younger than 18 years old. How should I take Januvia? Take Januvia exactly as it was prescribed for you. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended. You may take Januvia with or without food. Follow your doctor's instructions. Your blood sugar will need to be checked often, and you may need othe Continue reading >>

Buy Januvia, Generic Januvia (sitagliptin Phosphate) Online At Discount Prices

Buy Januvia, Generic Januvia (sitagliptin Phosphate) Online At Discount Prices

Please note that not all medications, including any referenced on this page, are dispensed from our affiliated Canadian pharmacy. The medications in your order may be filled and shipped from an approved International fulfillment center located in a country other than Canada. In addition to dispensing medications from our Canadian pharmacy, medication orders are also filled and shipped from international fulfillment centers that are approved by the regulatory bodies from their respective countries. Read More Medication orders are filled and shipped from approved fulfillment centers around the world including, but not limited to, Canada, Singapore, United Kingdom, New Zealand, Turkey, Mauritius, India, Australia, and the United States. The items in your order may be filled and shipped from any one of the above jurisdictions. The products are sourced from various countries including, but not limited to, Canada, United Kingdom, New Zealand, Turkey, India, Australia, and the United States. All of our affiliated fulfillment centers have been approved by the regulatory bodies from their respective countries. The active ingredient present in the drug is Sitagliptin and the inactive ingredients include microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, and sodium stearyl fumarate. Coating in the tablet is of polyvinyl alcohol, polyethylene glycol (macrogol), talc, titanium dioxide, red iron oxide, and yellow iron oxide. Sitagliptin belongs to DPP-4 inhibitors group of drug that increases the amount of incretin released by the intestine. Incretin is a type of hormone that increases insulin levels if blood sugar is high which will in turn reduce the amount of sugar in the blood. Sitagliptin works by inhibiting the enzyme di Continue reading >>

Januvia And Janumet

Januvia And Janumet

Januvia (sitagliptin) is an oral Type 2 diabetes medication manufactured by Merck & Co. The U.S. Food and Drug Administration (FDA) approved the drug in 2006, and it is one of the most popular Type 2 diabetes drugs on the market. In 2007, the FDA approved a variation of Januvia called Janumet, which is a combination of sitagliptin and metformin. Janumet also comes in an extended-release formula called Janumet XR. Januvia and Janumet are known as dipeptidyl peptidase 4 (DPP-4) inhibitors that work by helping the body produce more insulin. Both Januvia and Janumet belong to a class of drugs called dipeptidyl peptidase 4 (DPP-4) inhibitors that work by helping the body produce more insulin. Januvia was the first DPP-4 approved by the FDA and is the top-selling brand in its class. Two million prescriptions were written for Januvia in 2011. Januvia brought in about $6 billion in 2014. Merck stands to benefit from the patent on the drug until 2022. In clinical trials, Januvia proved effective in controlling blood-sugar levels. However, some studies reported rare and serious side effects, including acute pancreatitis, severe joint pain, pancreatic cancer and thyroid cancer. How Do Januvia and Janumet Work? Januvia is designed to work with other Type 2 diabetes medications, like Byetta, to increase their effectiveness. It helps lower blood sugar in two ways. It helps the body increase insulin to stabilize blood sugar and decrease sugars that are made in the liver. It is a part of the class of diabetes medications called DPP-4 inhibitors. DPP-4 is a protein made by the body that plays a role in glucose metabolism. The process works like this: After a person eats and blood sugar rises, intestinal cells release hormones called incretin hormones. Incretin stimulates pancreatic cell Continue reading >>

Merck Programs To Help Those In Need - Product

Merck Programs To Help Those In Need - Product

If you have been prescribed a Merck medicine, you may be eligible for the program if all 3 of the following conditions apply: You are a US resident and have a prescription for a Merck product from a health care provider licensed in the United States.* You do not have insurance or other coverage for your prescription medicine. Some examples of other insurance coverage include private insurance, HMOs, Medicaid, Medicare, state pharmacy assistance programs, veterans assistance, or any other social service agency support. You cannot afford to pay for your medicine. You may qualify for the program if you have a household income of $48,560 or less for individuals, $65,840 or less for couples, or $100,400 or less for a family of 4. At Merck we realize that sometimes exceptions need to be made based on the patient's individual circumstances. If you do not meet the prescription drug coverage criteria, your income meets the program criteria, and there are special circumstances of financial and medical hardship that apply to your situation, you can request that an exception be made for you. * You do not have to be a US citizen. Legal residents of the United States, including US Territories, are also eligible. For income limits in Alaska and Hawaii, please call 1-800-727-5400. If you believe that you meet the eligibility criteria for the Merck Patient Assistance Program and you have received a prescription for a Merck product, call toll-free 1-800-727-5400 8 AM to 8 PM EST to obtain a brochure outlining the program and an enrollment application, or by clicking on the link on the right. After downloading the application or receiving your packet in the mail, follow these simple steps to submit your enrollment form for your free Merck medicines: Complete ALL information on the enroll Continue reading >>

Lowers Your Blood Sugar.

Lowers Your Blood Sugar.

Our bottom line Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine. Oral blood sugar-lowering medicine. Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class. It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines. Lowers A1c (average blood sugar over time) by less than 1%. Rare but serious side effects include pancreatitis and severe joint pain. Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin. Sign up and get Pill Talk, the latest in health & medicine news from Iodine What to expect when you take Januvia (sitagliptin) for Type 2 diabetes Possible side effects Source: FDA product label and Iodine pharmacists Side effect rates for Januvia (sitagliptin) Where we got our data » Risks and Warnings for Januvia (sitagliptin) Higher risk if: › History of pancreatitis › High blood triglyceride levels › Gallstones (stones in gallbladder) › History of alchoholism › Kidney problems Januvia (sitagliptin) can cause a sudden inflammation of the pancreas. This can be life-threatening if not treated. Let your doctor know about any stomach pain, nausea, vomiting, or loss of appetite that doesn't go away. Frequently Asked Questions This medication treats type 2 diabetes in adults. Common concerns from people taking Januvia (sitagliptin) Take once a day in the morning with or without food. Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function. Tell your doctor right away if you have severe stomach pain, Continue reading >>

Sitagliptin

Sitagliptin

Sitagliptin (INN; /sɪtəˈɡlɪptɪn/ ( listen), previously identified as MK-0431 and marketed as the phosphate salt under the trade name Januvia) is an oral antihyperglycemic (antidiabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class. It was developed, and is marketed, by Merck & Co. This enzyme-inhibiting drug is used either alone or in combination with other oral antihyperglycemic agents (such as metformin or a thiazolidinedione) for treatment of diabetes mellitus type 2.[2] Adverse effects[edit] Side effects are as common with sitagliptin (whether used alone or with metformin or pioglitazone) as they were with placebo, except for rare nausea and common cold-like symptoms, including photosensitivity.[3] No significant difference exists in the occurrence of hypoglycemia between placebo and sitagliptin.[3][4][5] In those taking sulphonylureas, the risk of low blood sugar is increased.[6] The existence of rare case reports of renal failure and hypersensitivity reactions is noted in the United States prescribing information, but a causative role for sitagliptin has not been established.[7] Several postmarketing reports of pancreatitis (some fatal) have been made in people treated with sitagliptin and other DPP-4 inhibitors,[8] and the U.S. package insert carries a warning to this effect,[9] although the causal link between sitagliptin and pancreatitis has not yet been fully substantiated.[2] One study with lab rats published in 2009 concluded that some of the possible risks of pancreatitis or pancreatic cancer may be reduced when it is used with metformin. However, while DPP-4 inhibitors showed an increase in such risk factors, as of 2009, no increase in pancreatic cancer has been reported in individuals taking DPP-4 inhibitors.[10] The updated (August 20 Continue reading >>

Is Januvia An Effective Drug For Diabetes?

Is Januvia An Effective Drug For Diabetes?

Is Januvia an effective drug for diabetes? Dear Dr. Roach Is Januvia an effective drug for diabetes? What are the side effects? M.A.A. Answer Sitagliptin (Januvia) is an oral medication for diabetes mellitus. The way it works is complicated: It inhibits a molecule called DPP-4, which causes an increase in another molecule called glucagon-like peptide 1. GLP-1 causes decreased secretion of the anti-insulin hormone glucagon, so the net effect of Januvia is to block a hormone that opposes insulin. It may decrease hunger, and has a modest effect on blood sugar: In most clinical trials, it reduces the A1C level by 0.5 to 1 point. It is unlikely, by itself, to cause abnormally low blood sugars. Side effects include joint aches, which usually go away on stopping the medication. Allergic reactions are possible as well. In clinical trials, there were reports of pancreatitis, so any abdominal pain should be reported to your doctor. Diabetes has become epidemic in North America. The booklet on it provides insight on its diagnosis and treatment. Readers can order a copy by writing: Enclose a check or money order (no cash) for $4.75 U.S./$6 Can. with the recipients printed name and address. Please allow four weeks for delivery. Dear Dr. Roach My son doesnt like to visit me, as my home is too hot for him. I cannot visit him either, as I practically need a snowsuit in his home from fall through spring. Even in my own house, I cant bathe without a portable heater in the bathroom. I am concerned about low thyroid levels. E.W. Answer Although its possible your son is the one who is too warm, it sounds more likely that its you who is abnormally sensitive to cold. Cold intolerance is common in the elderly, especially in those who do not have a lot of body fat. However, you are quite right Continue reading >>

Do Januvia Side Effects Include Cancer Of The Pancreas?

Do Januvia Side Effects Include Cancer Of The Pancreas?

Q. My wife is taking Januvia to control her blood sugar. Without Januvia her sugar level is 130 or more. With Januvia it is in the range of 110, which is close to normal. I heard an interview on the radio that three medications to reduce blood sugar levels may have negative side effects, including cancer of the pancreas. Now I am wondering what is worse, pancreatic cancer or the effect of excessive sugar level in the blood. Our “medicine man” told my wife not to worry about side effects with Januvia. I have my doubts now and would welcome your thoughts. A. The story is quite complicated. Januvia (sitagliptin) belongs to a class of diabetes drugs called incretin mimetics. Incretin is a natural hormone produced by the body. It helps stimulate the pancreas to release insulin after a meal which leads to lower blood sugar levels. This category of medications mimics incretin. They include DPP-4 (dipeptidyl peptidase 4) inhibitors and GLP-1 agonists. That’s short hand for glucagon-like peptide-1 receptor agonists. Sorry for the hard-to-pronounce alphabet soup. But wait, it gets worse! The generic names for such drugs are also difficult to pronounce: Alogliptin (Nesina, Oseni) Exenatide (Byetta) Linagliptin (Tradjenta) Liraglutide (Victoza) Saxagliptin (Onglyza) Sitagliptin (Januvia, Janumet) Vildagliptin (Galvus) They have been extremely popular with diabetes doctors because they generally produce good numbers. That is to say they control blood glucose levels quite well and are often considered “well tolerated.” In other words, the medical community considers them as having few side effects. What About the Pancreas? Remember that these incretin mimetics work by stimulating the pancreas to make more insulin. A study published in the journal JAMA Internal Medicine (Apr Continue reading >>

Januvia

Januvia

JANUVIA® (sitagliptin) Tablets DESCRIPTION JANUVIA Tablets contain sitagliptin phosphate, an orally-active inhibitor of the dipeptidyl peptidase4 (DPP-4) enzyme. Sitagliptin phosphate monohydrate is described chemically as 7-[(3R)-3-amino-1-oxo-4-(2,4,5trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate (1:1) monohydrate. The empirical formula is C16H15F6N5O•H3PO4•H2O and the molecular weight is 523.32. The structural formula is: Sitagliptin phosphate monohydrate is a white to off-white, crystalline, non-hygroscopic powder. It is soluble in water and N,N-dimethyl formamide; slightly soluble in methanol; very slightly soluble in ethanol, acetone, and acetonitrile; and insoluble in isopropanol and isopropyl acetate. Each film-coated tablet of JANUVIA contains 32.13, 64.25, or 128.5 mg of sitagliptin phosphate monohydrate, which is equivalent to 25, 50, or 100 mg, respectively, of free base and the following inactive ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, and sodium stearyl fumarate. In addition, the film coating contains the following inactive ingredients: polyvinyl alcohol, polyethylene glycol, talc, titanium dioxide, red iron oxide, and yellow iron oxide. For Consumers What are the possible side effects of sitagliptin (Januvia)? Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking sitagliptin and call your doctor at once if you have a serious side effect such as: pancreatitis - severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, fast heart rate; or urinating less than usual Continue reading >>

Januvia

Januvia

NOTICE: This Consumer Medicine Information (CMI) is intended for persons living in Australia. What is in this leaflet This leaflet answers some common questions about JANUVIA. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking JANUVIA against the benefits they expect it will have for you. If you have any concerns about taking this medicine, ask your doctor or pharmacist. What JANUVIA is used for JANUVIA is used to lower blood sugar levels in patients with type 2 diabetes mellitus alone or in combination with certain other medicines (metformin, medicines such as rosiglitazone and pioglitazone, a sulfonylurea medicine such as glimepiride, gliclazide and glibenclamide, or insulin), when diet plus exercise or the other medicine(s) do not provide adequate blood sugar level control. Type 2 diabetes mellitus is a condition in which your body does not make enough insulin and the insulin that your body produces does not work as well as it should. Your body can also make too much sugar. When this happens, sugar (glucose) builds up in the blood. This can lead to serious medical problems. The main goal of treating diabetes is to lower your blood sugar to a normal level. Lowering and controlling blood sugar may help prevent or delay complications of diabetes, such as heart disease, kidney disease, blindness and amputation. High blood sugar can be lowered by diet and exercise and by certain medicines. How JANUVIA works JANUVIA is a member of a class of medicines you take by mouth called DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors) that lowers blood sugar levels in patients with type 2 diabetes mellitus. Type 2 diabetes mell Continue reading >>

Januvia New Fda Drug Approval | Centerwatch

Januvia New Fda Drug Approval | Centerwatch

Januvia is an orally-active inhibitor of the dipeptidylpeptidase-4 (DPP-4) enzyme. The DPP-4 enzyme inactivates incretinhormones, which are involved in the physiologic regulation ofglucose homeostasis. By inhibiting DPP-4, Januvia increases andprolongs active incretin levels. This in turn increases insulinrelease and decreases glucagon levels in the circulation in aglucose-dependent manner. Januvia is specifically indicated for the improvement ofglycemic control in patients with type II diabetes mellitus asmonotherapy or combination therapy with metformin or a peroxisomeproliferatoractivated receptor gamma (PPAR) agonist (e.g.,thiazolidinediones) when the single agent does not provide adequateglycemic control. Januvia is supplied as 25 mg, 50 mg or 100 mg tablets designedfor oral administration. The recommended initial dose of the drugis 100 mg once daily. FDA approval of Januvua was based on the pooled results of twodouble-blind, placebo controlled monotherapy studies and twodouble-blind, placebo controlled combination therapy studies. The Januvia monotherapy trials had one with an 18 week durationand one with a 24 week duration. In the 18-week study, 521 subjectswere randomized to placebo, Januvia 100 mg, or Januvia 200 mg, andin the 24-week study 741 subjects were randomized to placebo,Januvia 100 mg, or Januvia 200 mg. In both trials subjects wentunder a 7 week washout period then completed a 2-week,single-blind, placebo run-in period, before receiving treatment.Treatment with Januvia at 100 mg daily provided significantimprovements in A1C, FPG, and 2-hour PPG compared to placebo. Inthe 18-week study, 9% of patients receiving Januvia 100 mg and 17%who received placebo required rescue therapy. In the 24-week study,9% of patients receiving Januvia 100 mg and 21% of p Continue reading >>

Januvia Side Effect Lawsuit | Januvia Lawyer, Januvia Attorney

Januvia Side Effect Lawsuit | Januvia Lawyer, Januvia Attorney

Januvia has been linked to many severe, life-threatening side effects, including pancreatitis, low blood sugar, kidney problems, and allergic reactions. The FDA is also investigating the risk of pancreatic cancer, severe joint pain, and heart failure. The Schmidt Firm, PLLC is currently accepting Januvia induced pancreatic cancer cases in all 50 states. If you or somebody you know has been diagnosed with pancreatic cancer , you should contact our lawyers immediately for a free case consultation. Please use the form below to contact our Defective Drug Litigation Group or call us toll-free 24 hours a day at (866) 920-0753. The most common side effects of Januvia (experienced by at least 5% of patients) include headache, runny nose, and lung infections. The Prescribing Information (PDF) for Januvia includes warnings about the following severe side effects: Acute Pancreatitis: The use of DPP-4 inhibitors is associated with a risk of pancreatitis. Patients should be warned about this risk and seek medical attention for severe, persistent abdominal pain. Januvia has also been linked to cases of hemorrhagic and necrotizing pancreatitis and/or death. Hypoglycemia: This can occur when Januvia is used with other medications that lower blood-sugar levels, such as insulin and sulphonylureas (medications that force the pancreas to make more insulin). Kidney impairment: Januvia is removed from the bloodstream by the kidneys and excreted in urine. The dose should be limited in patients who have moderate to severe kidney problems. Allergic reactions: Serious hypersensitivity reactions have been reported in patients on Januvia, including angioedema and skin conditions like Stevens-Johnson Syndrome. These reactions occurred during the first 3 months the patient was on Januvia. On March Continue reading >>

Januvia: Targets Root Problems Of Type 2 Diabetes

Januvia: Targets Root Problems Of Type 2 Diabetes

Sitagliptin increases insulin production and decreases hepatic glucose overproduction By enhancing active incretin levels, sitagliptin increases insulin production and lowers glucagon secretion from alpha cells, which decreases hepatic glucose overproduction GLP-1 = glucagon-like peptide-1; GIP = glucose-dependent insulinotropic polypeptide Important Information JANUVIA is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. JANUVIA should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis. JANUVIA has not been studied in patients with a history of pancreatitis. It is unknown whether patients with a history of pancreatitis are at increased risk of developing pancreatitis while taking JANUVIA. Selected Important Risk Information About JANUVIA® (sitagliptin) tablets JANUVIA is contraindicated in patients with a history of a serious hypersensitivity reaction to sitagliptin, such as anaphylaxis or angioedema. There have been postmarketing reports of acute pancreatitis, including fatal and nonfatal hemorrhagic or necrotizing pancreatitis, in patients taking JANUVIA. After initiating JANUVIA, observe patients carefully for signs and symptoms of pancreatitis. If pancreatitis is suspected, promptly discontinue JANUVIA and initiate appropriate management. It is unknown whether patients with a history of pancreatitis are at increased risk of developing pancreatitis while taking JANUVIA. An association between dipeptidyl peptidase-4 (DPP-4) inhibitor treatment and heart failure has been observed in cardiovascular outcomes trials for two other members of the DPP-4 inhibitor class. These trials evaluated patients with type 2 diabetes mellitus and atherosclerotic cardiovascular disea Continue reading >>

Januvia (sitagliptin) Brand Name

Januvia (sitagliptin) Brand Name

Sign up for our newsletter for email updates on new medications, store specials and coupons available to newsletter subscribers only. Product Details for Januvia (Sitagliptin) Brand Name Januvia Global Pharmacy Plus ships out is Brand Name. We source the Brand Name Jauntier through our partner European pharmacy. By sourcing Januvia in Europe we can pass the savings along to you. Januvia is a dipeptidyl peptidase-4 (DPP-4) inhibitor used to treat type 2 diabetes in patients who cannot control blood sugar levels by diet and exercise. It is used along with diet and exercise. This medicine may be taken alone or in combination with others. Insulin is a hormone, which is made naturally in your body in the pancreas. Insulin helps to control the levels of sugar in your blood. If your body does not make enough, or if it does not use the insulin it makes effectively, this results in the condition called sugar diabetes (diabetes mellitus). People with diabetes need treatment to control the amount of sugar (glucose) in their blood. This is because good control of blood glucose levels reduces the risk of complications later on. Some people can control the sugar in their blood by making changes to the food they eat but, for other people, medicines like Januvia / Sitagliptin are given alongside the changes in diet. Januvia / Sitagliptin works in part by increasing the amount of insulin produced by your body. It also reduces the amount of a substance called glucagon being produced by your pancreas. Glucagon causes your liver to produce more sugar, so by reducing the amount of glucagon in your body, this also helps to reduce the levels of glucose in your blood. Continue reading >>

What Is Januvia?

What Is Januvia?

Januvia is a prescription medication used to treat adults with type 2 diabetes. When used as part of a healthy lifestyle plan encompassing exercise and diet, Januvia helps patients control their blood sugar levels. Januvia, a type 2 diabetes medication manufactured by Merck & Co., generates an estimated $6 billion in sales each year. The FDA approved Januvia for treating type 2 diabetes in 2006. Since hitting the market, it has become one of the most commonly prescribed medications to reduce blood sugar levels in patients with type 2 diabetes. By managing blood sugar, Januvia lessens the risk of other medical conditions caused by type 2 diabetes such as heart disease, kidney damage and eye problems. Unfortunately, there are several long-term risks associated with Januvia that can impact a person’s life forever. Numerous reports have linked Januvia to different cancers including pancreatic cancer and thyroid cancer. Even with new, stricter label requirements, Merck & Co. has been sued over their negligence to inform consumers about life-threatening side effects. SIDE EFFECTS of JANUVIA While there are many benefits of taking Januvia to help control your type 2 diabetes, some people may experience adverse side effects. Many side effects are minor and not harmful to your health. However, if you experience severe side effects that do not go away, you should seek medical attention immediately. Pancreatic cancer, thyroid cancer and acute pancreatitis are several of the most dangerous side effects of Januvia. Because of this, let your health provider know if you have a medical history of pancreatitis, gallstones or kidney problems. Januvia may also cause changes in your blood sugar levels. High or low blood pressure makes you susceptible to various complications such as a he Continue reading >>

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