diabetestalk.net

Janumet Vs Januvia Metformin

Compare Janumet Vs Januvia - Iodine.com

Compare Janumet Vs Januvia - Iodine.com

Head-to-head comparisons of medication uses, side effects, ratings, and more. Janumet is a combination of two anti-diabetic medicines that work better together, but is available as brand only. 3.4/ 5 average rating with 79 reviewsforJanumet Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine. 3.2/ 5 average rating with 143 reviewsforJanuvia This 2-in-1 combination can lower the number of pills you have to take daily. Lowers A1c (average blood sugar over time) up to 2.5%. Available in extended and immediate release forms to allow better control of your blood sugar. Doesn't increase your appetite unlike other anti-diabetic medicines. Does not cause hypoglycemia or very low blood sugar. Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class. Uses the hormones naturally produced by your body to affect how sugar is processed. It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines. Available as brand name only and may be expensive. Metformin component usually causes upset stomach. Sitagliptin component may increase your risk for throat infections and inflammation of pancreas. Not appropriate for those with poor kidney function. Lowers A1c (average blood sugar over time) by less than 1%. Some people might get frequent cold-like symptoms. Rare but serious side effects include pancreatitis and severe joint pain. Continue reading >>

Learn About Janumet Xr

Learn About Janumet Xr

JANUMET tablets contain 2 prescription medicines: sitagliptin (JANUVIA®) and metformin. Once-daily prescription JANUMET XR tablets contain sitagliptin (the medicine in JANUVIA®) and extended-release metformin. JANUMET or JANUMET XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. JANUMET or JANUMET XR should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUMET or JANUMET XR. Metformin, one of the medicines in JANUMET and JANUMET XR, can cause a rare but serious side effect called lactic acidosis (a buildup of lactic acid in the blood), which can cause death. Lactic acidosis is a medical emergency that must be treated in a hospital. Call your doctor right away if you get any of the following symptoms, which could be signs of lactic acidosis: feel cold in your hands or feet; feel dizzy or lightheaded; have a slow or irregular heartbeat; feel very weak or tired; have unusual (not normal) muscle pain; have trouble breathing; feel sleepy or drowsy; have stomach pains, nausea, or vomiting. Most people who have had lactic acidosis with metformin have other things that, combined with the metformin, led to the lactic acidosis. Tell your doctor if you have any of the following, because you have a higher chance of getting lactic acidosis with JANUMET or JANUMET XR if you: have severe kidney problems or your kidneys are affected by certain x-ray tests that use injectable dye; have liver problems; drink alcohol very often, or drink a lot of alcohol in short-term “binge” drinking; get dehydrated (lose large amounts of body fluids, w Continue reading >>

What Are The Possible Side Effects Of Metformin And Sitagliptin (janumet, Janumet Xr)?

What Are The Possible Side Effects Of Metformin And Sitagliptin (janumet, Janumet Xr)?

JANUMET® XR (sitagliptin and metformin HCl) Extended-Release Tablets JANUMET XR tablets contain two oral antidiabetic medications used in the management of type 2 diabetes: sitagliptin and metformin hydrochloride extended-release. Sitagliptin Sitagliptin is an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Sitagliptin phosphate monohydrate drug substance is used to manufacture JANUMET XR. Sitagliptin phosphate monohydrate is described chemically as 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazine phosphate (1:1) monohydrate with an empirical formula of C16H15F6N5O•H3PO4•H2O and a molecular weight of 523.32. The structural formula is: Sitagliptin phosphate monohydrate is a white to off-white, crystalline, non-hygroscopic powder. It is soluble in water and N,N-dimethyl formamide; slightly soluble in methanol; very slightly soluble in ethanol, acetone, and acetonitrile; and insoluble in isopropanol and isopropyl acetate. Metformin Hydrochloride Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride) is a white to off-white crystalline compound with a molecular formula of C4H11N5•HCl and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68. The structural formula is as shown: JANUMET XR consists of an extended-release metformin core tablet coated with an immediate-release layer of sitagliptin. The sitagliptin layer is coated with a soluble polymeric film. JANUMET XR is available for oral administration as tablets containing 64.25 mg sitagliptin phosphate monohyd Continue reading >>

What Patients Say About Janumet 50 1000

What Patients Say About Janumet 50 1000

Janumet 50 1000 ( see details ) is the brand name (and dosage level) of sitagliptin-metformin , a combination prescription drug used in the management of type 2 diabetes . (50 refers to 50 mg of sitagliptin while 1000 refers to 1000 mg of metformin .) In addition to diet and exercise, Janumet 50 1000 is prescribed when the use of metformin or sitagliptin alone does not adequately control the condition. At PatientsLikeMe , where more than 130,000 patients are sharing their experiences with conditions , symptoms , treatments and more, 21 patients report using Janumet 50 1000 or a lower daily dosage (50 mg sitagliptin / 500 mg metformin). What can we learn from these patients experiences? Quite a bit, actually, thanks to PatientsLikeMes unique data-sharing platform. Looking at the three treatment evaluations submitted for Janumet, all three patients rate the effectiveness as Moderate, while side effects were marked as Mild, Moderate and Severe, respectively. The chief complaint from the patient who reported Severe side effects was diarrhea . However, she writes, Blood sugars are going down. What about you? Have you taken Janumet 50 1000 or a different dosage of this combination diabetes medication? Join PatientsLikeMe and add your experiences to our growing body of knowledge. Then, stay to exchange advice and support, research common treatments and learn from other patients like you. Continue reading >>

Comparing Diabetes Drugs: Januvia Vs. Victoza

Comparing Diabetes Drugs: Januvia Vs. Victoza

blood sugar control and lost more weight than patients who took the widely prescribed oral drug Januvia, a study shows. The trial is the first to compare two classes of diabetes drugs that target insulin-regulating hormones in the gut known as incretins, researchers say. Incretin-based drugs are most often prescribed to patients who do not achieve target blood sugar levels with the drug metformin or other oral agents for diabetes. Introduced early this year, Victoza is one of two FDA-approved drugs that mimic the activity of the naturally occurring incretin hormone GLP-1. The other is the twice-daily injected drug Byetta. Januvia works by blocking DDP-4, a key enzyme that breaks down GLP-1. Both classes of drugs increase insulin secretion and decrease secretion of the hormone glucagon, which raises blood sugar. In the new study, published April 24 in TheLancet, 665 type 2 diabetes patients who failed to achieve target blood sugar levels with metformin alone were treated with either once-daily injections of Victoza, at doses of 1.2 milligrams or 1.8 milligrams, or 100 milligrams of Januvia, taken by mouth once a day. Over 26 weeks of treatment, patients on the highest dosage of the injected drug achieved the best blood sugar control and the most weight loss. A main focus of the study was how well the two drugs lowered A1c, which measures blood sugar control over time. Nearly twice as many patients taking Victoza reached a target A1c level of less than 7%, according to study researcher Richard Pratley, MD, of the University of Vermont College of Medicine. The study was funded by Victoza manufacturer Novo Nordisk, which also participated in the study design, data collection, and data analysis. Pratley also acknowledged receiving consulting fees from both Novo Nordisk and M Continue reading >>

The Difference Between

The Difference Between

JANUMET tablets contain 2 prescription medicines: sitagliptin (JANUVIA®) and metformin. Once-daily prescription JANUMET XR tablets contain sitagliptin (the medicine in JANUVIA®) and extended-release metformin. JANUMET or JANUMET XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. JANUMET or JANUMET XR should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUMET or JANUMET XR. Metformin, one of the medicines in JANUMET and JANUMET XR, can cause a rare but serious side effect called lactic acidosis (a buildup of lactic acid in the blood), which can cause death. Lactic acidosis is a medical emergency that must be treated in a hospital. Call your doctor right away if you get any of the following symptoms, which could be signs of lactic acidosis: feel cold in your hands or feet; feel dizzy or lightheaded; have a slow or irregular heartbeat; feel very weak or tired; have unusual (not normal) muscle pain; have trouble breathing; feel sleepy or drowsy; have stomach pains, nausea, or vomiting. Most people who have had lactic acidosis with metformin have other things that, combined with the metformin, led to the lactic acidosis. Tell your doctor if you have any of the following, because you have a higher chance of getting lactic acidosis with JANUMET or JANUMET XR if you: have severe kidney problems or your kidneys are affected by certain x-ray tests that use injectable dye; have liver problems; drink alcohol very often, or drink a lot of alcohol in short-term “binge” drinking; get dehydrated (lose large amounts of body fluids, w Continue reading >>

Fda Approves Combo Of Januvia Plus Metformin In Once A Day Dosage

Fda Approves Combo Of Januvia Plus Metformin In Once A Day Dosage

The FDA approved JANUMET® XR (sitagliptin and metformin hydrochloride (HCl) extended-release) tablets, a treatment for type 2 diabetes that combines sitagliptin, which is the active component of JANUVIA® (sitagliptin), with extended-release metformin…. JANUMET XR provides a convenient once-daily treatment option for patients who need help to control their blood sugar. JANUMET XR is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes when treatment with both sitagliptin and extended-release metformin is appropriate. JANUMET XR should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis. JANUMET XR has not been studied in patients with a history of pancreatitis. It is unknown whether patients with a history of pancreatitis are at increased risk for the development of pancreatitis while using JANUMET XR. The FDA approved JANUMET XR based upon a clinical bioequivalence study that demonstrated that administration of JANUMET XR was equivalent to co-administration of corresponding doses of the two individual medications, sitagliptin and metformin HCl extended- release. Extended-release metformin was as effective as immediate-release metformin. The labeling for JANUMET XR contains a boxed warning for lactic acidosis, a rare, but serious complication that can occur due to metformin accumulation. JANUMET XR is contraindicated in patients with renal impairment (e.g., serum creatinine levels ≥1.5 mg/dL for men, ≥1.4 mg/dL for women or abnormal creatinine clearance), which may also result from conditions such as cardiovascular collapse (shock), acute myocardial infarction, and septicemia; hypersensitivity to metformin HCl; acute or chronic metabolic acidosis, including diabetic ketoacid Continue reading >>

Fixed Combination Of Sitagliptin And Metformin (janumet Or Velmetia) For Type 2 Diabetes: Overview

Fixed Combination Of Sitagliptin And Metformin (janumet Or Velmetia) For Type 2 Diabetes: Overview

PubMed Health. A service of the National Library of Medicine, National Institutes of Health. Informed Health Online [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. Fixed combination of sitagliptin and metformin (Janumet or Velmetia) for type 2 diabetes: Overview Last Update: October 20, 2016; Next update: 2019. The fixed combination of sitagliptin and metformin has been approved in Germany since July 2008 for the treatment of type 2 diabetes in adults who have not been able to lower their blood sugar levels enough through diet and exercise alone. The combination (trade name: Janumet or Velmetia) is suitable for people who do not benefit enough from taking metformin alone and for people who are already taking sitagliptin and metformin as separate tablets. It can also be used with a sulfonylurea or insulin if treatment with a combination of one of these drugs and metformin is not effective enough at lowering blood sugar levels. Diabetes is a metabolic disease that affects many parts of the body. In type 2 diabetes , the pancreas still produces enough insulin at first, but the bodys cells gradually lose the ability to absorb and use the insulin. If blood sugar levels cannot be lowered enough through a change in diet and exercise habits, blood-sugar-lowering medication is used. The aim of treatment in type 2 diabetes is to avoid strong fluctuations in blood sugar levels and the effects of high and low blood sugar . A further goal of this treatment is to prevent long-term complications that may arise if blood sugar levels are too high. One tablet contains 50 mg of sitagliptin and either 850 mg or 1000 mg of metformin . If sitagliptin/metformin is combined with other blood - sugar -lowering drugs, the doses must be adjusted a Continue reading >>

Metformin And Sitagliptin (janumet)

Metformin And Sitagliptin (janumet)

are allergic to dapagliflozin or any of the ingredients in FARXIGA. Symptoms of a serious allergic reaction may include skin rash, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. If you have any of these symptoms, stop taking FARXIGA and contact your healthcare provider or go to the nearest hospital emergency room right away have severe kidney problems or are on dialysis. Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with FARXIGA Dehydration (the loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at a higher risk of dehydration if you have low blood pressure; take medicines to lower your blood pressure, including water pills (diuretics); are 65 years of age or older; are on a low salt diet, or have kidney problems Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with FARXIGA. Ketoacidosis is a serious condition which may require hospitalization and may lead to death. Symptoms may include nausea, tiredness, vomiting, trouble breathing, and abdominal pain. If you get any of these symptoms, stop taking FARXIGA and call your healthcare provider right away. If possible, check for ketones in your urine or blood, even if your blood sugar is less than 250 mg/dL Kidney problems. Sudden kidney injury occurred in people taking FARXIGA. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or excessive heat exposure Serious urinary tract infections (UTI), some that lead to hospitalization, occu Continue reading >>

Prescription Discounts Up To 75% Off

Prescription Discounts Up To 75% Off

Living with Type 2 Diabetes can be a challenge, but a balance of diet and exercise and the right prescription medication can make life much easier. Januvia and Janumet are two oral medications that can help lower blood sugar in adults with Type 2 Diabetes. Lowering blood sugar in this condition can save you from health problems in the future including kidney and heart issues. Januvia vs. Janumet The main acting ingredient in Januvia is Sitagliptin. Sitagliptin increases the production of GLP-1 and GIP hormones in your body. These hormones are responsible for helping to lower blood sugar and stimulating insulin production in your pancreas. This insulin is essential to keeping your blood sugar from getting too high or too low. Janumet is actually made up of two drugs, Sitagliptin and Metformin. Like in Januvia, the sitagliptin produces insulin, while the addition of Metformin helps to control the amount of glucose in your blood. Metformin lowers the amount of glucose you take in from your food and increases your body’s response to insulin. Some patients may already be taking Metformin on its own, but the addition of the Sitagliptin helps to lower blood sugar even more. If you are unable to take Metformin, Januvia can be a great and safer option. A balanced diet and regular exercise are key while taking both of these medications. Consult your doctor to develop a diet and exercise plan that will be easy to maintain long term. Neither medication should be used as a substitute for a healthy diet and consistent exercise. Side Effects Serious side effects may occur, which is why it is essential to talk to a doctor before taking either medication. Be sure to alert your doctor of previous medical conditions, especially pancreatitis, kidney problems, and liver problems. If you d Continue reading >>

Janumet Reviews & Ratings At Drugs.com

Janumet Reviews & Ratings At Drugs.com

5'-11" 294lbs 65 y.o. (taken for 2 to 5 years) January 15, 2018 For Diabetes, Type 2 "Reduced sugar level from high 12+ to 5.4 low to 7 high.In my case, side effects cause gas and diarrhea." Cosber (taken for 1 to 6 months) January 12, 2018 Did you? Yes No | Report inappropriate For Diabetes, Type 2 "I was on Metaformin for 20+ years and after the last A1c Test, doctor put on 50/850 Janumet plus FORXIGA Noticed rash on my body and need to scratch until bloody (annoying) However, not sure which medicine of the two new ones that is making me scratch my body from top to down. I'm planning to see the doctor next week" For Diabetes, Type 2 "I am a user of Janumet. It's not good that janumets packaging gives you a cut while opening its packaging since you are a diabetic thats why you are taking janumet" Did you? Yes No | Report inappropriate For Diabetes, Type 2 "Just started taking Janumet 1000 my yesterday. Luckily my daughter who studies Med at Uni read the instructions. I had a headache which she said was low blood sugar. After I ate something the headache disappeared. I have got severe diarrhea though both nights, OK in the morning???" Ted Rob (taken for less than 1 month) July 28, 2017 Did you? Yes No | Report inappropriate For Diabetes, Type 2 "I have been using Janumet 50/1000 for the past 2 yrs, No side effects and my blood sugar levels and HbA1c is below 7 and I am quite satisfied with the medicine. But the medicine is very expensive, it is on a the higher side. Manufacturer must reduce its price in India and it should be brought under Price controlled Diabetic Drugs List" Anantaram K (taken for 2 to 5 years) June 10, 2017 Did you? Yes No | Report inappropriate For Diabetes, Type 2 "This medication is overpriced rubbish. Maybe it works well for those who absolutely Continue reading >>

Glyburide Vs. Januvia/janumet

Glyburide Vs. Januvia/janumet

I have not been able to hit my target numbers on the 1500mg Metformin I was on. My A1C in October was 7.3 and this week it was 8.3. I've been seeing a general physician for my management and she recommened upping the Metformin to 2000mg and adding 5mg of Glyburide once a day. I went and saw an Endo. and he recommened upping the Metformin to 2000mg as well but wanted to add 100mg of Januvia until I finished up my current supply of Metformin at which time I'd switch to Janumet 50/1000mg twice per day. I started takinig Glyburide for the first time this morning after breakfast along with my Metformin. Three hours later I was going hypo. with a bgl of 65. I had lunch and a little OJ and i"m up in the mid to high 90's. Which is great because ever since my DX I have not been able to get below 140 bgl. I am worried that Glyburide will cause me to go hypo frequently and it scares me as I have never had to deal with that. I've read that Januvia only works when your BGL is high and does not induce hypos. Ok, so here's the conundrum: A 30 day supply of Glyburide costs be $1.62. A thirty day supply of Januvia or Janumet will cost me A little over $50. I filled my scripts yesterday for a thirtyday supply each of Metformin, Glyburide and an ACE inhibitor (don't recall name-switching from Altace) all for $4.62 What to do? Continue on the Glyburide to see how it works out for me? Or just switch to Januvia? Obviously Januvia's expense makes it less appealing. So...you get all 3 Rx for just $4.62? WOW! cool deal... I take Januvia and from what I understand it is suppose to help your pancreas make more insulin to help lower the BG and signals your liver to make less sugar. I take my dose at bedtime to help my BG in the morning...but an increase of $45/mo for meds is kind of a big jump in Continue reading >>

The Pros And Cons Of Januvia And Janumet

The Pros And Cons Of Januvia And Janumet

Januvia (sitagliptin) doesnt usually cause weight loss or gain.(JASON REEKIE/ISTOCK/HEALTH)Januvia (sitagliptin) is a type 2 diabetes drug that was approved in 2006. It is also available in a combination pill (known as Janumet) that contains the drug metformin. They are the first drugs in a new class called the selective dipeptidyl peptidase-4 inhibitors, or DPP-4 inhibitors. Januvia has a big advantage in that it can stimulate insulin production in the body, and may be less likely to cause hypoglycemia than other drugs. If blood glucose falls too low, the drug ceases to stimulate insulin production. The disadvantage? The price. The drug is "very expensive," says Glenn Cunningham, MD, an endocrinologist and professor at Baylor College of Medicine in Houston. He notes that it costs $160 for a 30-day supply of 100-mg tablets. Nevertheless, "Januvia is becoming a much more popular drug," Dr. Cunningham says. It does not cause weight gain or weight loss, he explained, and is less likely to cause hypoglycemia. Continue reading >>

Similarities And Differences Between Januvia Vs Janumet

Similarities And Differences Between Januvia Vs Janumet

Similarities and Differences Between Januvia vs Janumet Similarities and Differences Between Januvia vs Janumet Januvia, which is also known as sitagliptin, is a diabetes drug that is used to reduce high amounts of blood sugar in type 2 diabetic people. Sitagliptin belongs to a class of diabetes medicines known as DPP-4 inhibitors . DPP-4 inhibitors such as Januvia work by blocking the action of an enzyme called DPP-4, which is responsible for destroying incretin hormones. Incretin is a hormone that helps to regulate blood sugar levels by increasing insulin production and reducing how much glucose the liver produces. Januvia comes in tablet form that is supposed to be taken orally together with meals or without. Janumet is a combination prescription medicine that contains both sitagliptin and metformin. Both metformin and sitagliptin are oral diabetes drugs that help in reducing high amounts of blood glucose. The sitagliptin that is contained in this prescription drug works by increasing the amount of incretin hormones and reducing the amount of glucose that is produced by your liver. Metformin works by improving the bodys sensitivity to insulin. Janumet is commonly prescribed with a healthy diet and proper exercise program to regulate blood glucose levels in type 2 diabetic people. Similarities and differences between Januvia vs Janumet Both Januvia and Janumet are oral diabetes medicines that are used to treat patients who have type 2 diabetes.Both medications can be used alone or together with other diabetes drugs to control high amounts of blood sugar. However,these drugs should not be used to treat people who have type 1 diabetes. Another similarity is that bothmedications are available as brand drugs only. Whereas Januvia is a single prescription drug that has si Continue reading >>

Janumet Side Effects Center

Janumet Side Effects Center

Janumet (sitagliptin/metformin HCl) is a combination of oral diabetes medicines for people with type 2 diabetes who do not use daily insulin injections. Janumet is not for treating type 1 diabetes. Common side effects of Janumet include: nausea, vomiting, stomach upset, diarrhea, constipation, headache, weakness, back pain, joint or muscle pain, a metallic taste in the mouth, or cold symptoms such as runny or stuffy nose, sneezing, and sore throat. Janumet does not usually cause low blood sugar (hypoglycemia). Low blood sugar may occur if Janumet is prescribed with other anti-diabetic medications. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. Dosage of Janumet is individualized. Janumet is given twice daily with meals in 50 mg sitagliptin/500 mg metformin hydrochloride or 50 mg sitagliptin/1000 mg metformin hydrochloride doses. Hyperglycemia (high blood sugar) may result if you take Janumet with drugs that raise blood sugar, such as: isoniazid, diuretics (water pills), steroids, phenothiazines, thyroid medicine, birth control pills and other hormones, seizure medicines, and diet pills, or medicines to treat asthma, colds or allergies. Hypoglycemia (low blood sugar) may result if you take Janumet with drugs that lower blood sugar, such as: nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), beta-blockers, or probenecid. It may also interact with amiloride, triamterene, cimetidine, ranitidine, digoxin, furosemide, morphine, nifedipine, procainamide, quinidine, trimethoprim, or vancomycin. Tell your doctor all medications you use. During pregnancy, Janumet should be used only when prescribed. Your doctor may Continue reading >>

More in diabetes