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Janumet Vs Januvia Cost

Januvia Virtually Identical To Glipizide Over 2 Years--another Misreported Study

Januvia Virtually Identical To Glipizide Over 2 Years--another Misreported Study

NOTE (April 2, 2013): Before you take Onglyza or Januvia please read about the new research that shows that they, and probably all incretin drugs, cause severely abnormal cell growth in the pancreas and precancerous tumors. You'll find that information HERE. ==== A recent study compared the effect of taking the very cheap generic sulfonylurea drug glipizide to the new extremely expensive drug Januvia. The abstract reports the results as if they meant that Januvia was far superior to glipizide in preserving insulin secretion, reducing weight, and avoiding hypos. Fortunately, the entire study is available online for free, and I was able to see the actual statistics. What they showed, very clearly, was that the differences here were statistically significant--i.e. they probably weren't attributable to random variation--but not significant in terms of the impact on patient health. Given that Januvia costs $190 a month and glipizide costs $4 a month (on many pharmacy generic drug savings plans) it's worth taking a closer look at the statistics. Here's the full text article: Safety and Efficacy of Treatment with Sitagliptin or Glipizide in Patients with Type 2 Diabetes Inadequately Controlled on Metformin: A 2-year Study. T. Seck et al,. Int J Clin Pract. 2010;65(5):562-576. The study involved 1172 people with starting A1cs ranging from 5.8 to 9.1%, divided into two groups. All took metformin and half each took Januvia or glipizide. As is common with randomization, there were subtle differences between the groups. Most significantly the glipizide group had 5.6% more males than the Januvia group and the glipizide group as a whole started out with a greater BMI, a slightly higher fasting glucose, and more members with very high A1cs. I mention this because the statistically sig Continue reading >>

The Pros And Cons Of Januvia And Janumet

The Pros And Cons Of Januvia And Janumet

Januvia (sitagliptin) doesnt usually cause weight loss or gain.(JASON REEKIE/ISTOCK/HEALTH)Januvia (sitagliptin) is a type 2 diabetes drug that was approved in 2006. It is also available in a combination pill (known as Janumet) that contains the drug metformin. They are the first drugs in a new class called the selective dipeptidyl peptidase-4 inhibitors, or DPP-4 inhibitors. Januvia has a big advantage in that it can stimulate insulin production in the body, and may be less likely to cause hypoglycemia than other drugs. If blood glucose falls too low, the drug ceases to stimulate insulin production. The disadvantage? The price. The drug is "very expensive," says Glenn Cunningham, MD, an endocrinologist and professor at Baylor College of Medicine in Houston. He notes that it costs $160 for a 30-day supply of 100-mg tablets. Nevertheless, "Januvia is becoming a much more popular drug," Dr. Cunningham says. It does not cause weight gain or weight loss, he explained, and is less likely to cause hypoglycemia. Continue reading >>

Prescription Discounts Up To 75% Off

Prescription Discounts Up To 75% Off

Living with Type 2 Diabetes can be a challenge, but a balance of diet and exercise and the right prescription medication can make life much easier. Januvia and Janumet are two oral medications that can help lower blood sugar in adults with Type 2 Diabetes. Lowering blood sugar in this condition can save you from health problems in the future including kidney and heart issues. Januvia vs. Janumet The main acting ingredient in Januvia is Sitagliptin. Sitagliptin increases the production of GLP-1 and GIP hormones in your body. These hormones are responsible for helping to lower blood sugar and stimulating insulin production in your pancreas. This insulin is essential to keeping your blood sugar from getting too high or too low. Janumet is actually made up of two drugs, Sitagliptin and Metformin. Like in Januvia, the sitagliptin produces insulin, while the addition of Metformin helps to control the amount of glucose in your blood. Metformin lowers the amount of glucose you take in from your food and increases your body’s response to insulin. Some patients may already be taking Metformin on its own, but the addition of the Sitagliptin helps to lower blood sugar even more. If you are unable to take Metformin, Januvia can be a great and safer option. A balanced diet and regular exercise are key while taking both of these medications. Consult your doctor to develop a diet and exercise plan that will be easy to maintain long term. Neither medication should be used as a substitute for a healthy diet and consistent exercise. Side Effects Serious side effects may occur, which is why it is essential to talk to a doctor before taking either medication. Be sure to alert your doctor of previous medical conditions, especially pancreatitis, kidney problems, and liver problems. If you d Continue reading >>

Similarities & Differences Between Tradjenta Vs Januvia

Similarities & Differences Between Tradjenta Vs Januvia

Tradjenta, the brand name of Linagliptin, is an oral diabetes drug that is prescribed to patients with type 2 diabetes. This medication works by regulating the amount of insulin the pancreas produces after eating a meal. Linagliptin can be used alone or in combination with other diabetes drugs to reduce high blood glucose levels in people with type 2 diabetes. The drug used together with exercise, diet, weight control and blood glucose testing. You should not change any of these factors in order to avoid affecting your blood glucose levels. Januvia is the brand name of Sitagliptin , and is used to treat patients with type 2 diabetes. It can be used together with other diabetes drugs, but should not be used to treat type 1 diabetes . This medication is supposed to be taken orally, and can be taken with or without food. Your dosage will vary depending on how you respond to treatment, your medical condition, and kidney function. You should not take this medication if you are in a state of diabetic ketoacidosis or you are allergic to Sitagliptin. Similarities and Differences Between Tradjenta vs Januvia Both Tradjenta and Januvia are oral medications that are used together with an exercise and diet program to control high blood glucose in patients with type 2 diabetes.The medications can be prescribed to patients with type 2 diabetes to help them control their blood glucose levels. Thus, reducing the risk of long-term health problems. However,these medications should not be used to treat patients who are under the age of 18. Bothdrugs belongs to a class of medications known as DPP-4 inhibitors . DPP-4 inhibitors are responsible for blocking the action of an enzyme called DPP-4 that destroys incretins, which reduces blood sugar levels. This helps to reduce high levels of bl Continue reading >>

Compare Janumet Vs Januvia - Iodine.com

Compare Janumet Vs Januvia - Iodine.com

Head-to-head comparisons of medication uses, side effects, ratings, and more. Janumet is a combination of two anti-diabetic medicines that work better together, but is available as brand only. 3.4/ 5 average rating with 79 reviewsforJanumet Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine. 3.2/ 5 average rating with 143 reviewsforJanuvia This 2-in-1 combination can lower the number of pills you have to take daily. Lowers A1c (average blood sugar over time) up to 2.5%. Available in extended and immediate release forms to allow better control of your blood sugar. Doesn't increase your appetite unlike other anti-diabetic medicines. Does not cause hypoglycemia or very low blood sugar. Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class. Uses the hormones naturally produced by your body to affect how sugar is processed. It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines. Available as brand name only and may be expensive. Metformin component usually causes upset stomach. Sitagliptin component may increase your risk for throat infections and inflammation of pancreas. Not appropriate for those with poor kidney function. Lowers A1c (average blood sugar over time) by less than 1%. Some people might get frequent cold-like symptoms. Rare but serious side effects include pancreatitis and severe joint pain. Continue reading >>

(sitagliptin And Metformin Hcl) Tablets Or

(sitagliptin And Metformin Hcl) Tablets Or

JANUMET tablets contain 2 prescription medicines: sitagliptin (JANUVIA®) and metformin. Once-daily prescription JANUMET XR tablets contain sitagliptin (the medicine in JANUVIA®) and extended-release metformin. JANUMET or JANUMET XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. JANUMET or JANUMET XR should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUMET or JANUMET XR. Selected Risk Information About JANUMET and JANUMET XR Metformin, one of the medicines in JANUMET and JANUMET XR, can cause a rare but serious side effect called lactic acidosis (a buildup of lactic acid in the blood), which can cause death. Lactic acidosis is a medical emergency that must be treated in a hospital. Call your doctor right away if you get any of the following symptoms, which could be signs of lactic acidosis: feel cold in your hands or feet; feel dizzy or lightheaded; have a slow or irregular heartbeat; feel very weak or tired; have unusual (not normal) muscle pain; have trouble breathing; feel sleepy or drowsy; have stomach pains, nausea, or vomiting. Most people who have had lactic acidosis with metformin have other things that, combined with the metformin, led to the lactic acidosis. Tell your doctor if you have any of the following, because you have a higher chance of getting lactic acidosis with JANUMET or JANUMET XR if you: have severe kidney problems or your kidneys are affected by certain x-ray tests that use injectable dye; have liver problems; drink alcohol very often, or drink a lot of alcohol in short-term “binge” drinkin Continue reading >>

Combination Drug Offers New Option For Diabetes

Combination Drug Offers New Option For Diabetes

Combination drug offers new option for diabetes Patients with Type 2 diabetes whose blood glucose is not adequately controlled with metformin or sitagliptin (Januvia, Merck) alone will now have a new option. Last month, the Food & Drug Administration approved a two-in-one product from Merck. Janumet, containing both metformin and sitagliptin, is also for use in patients already taking the two drugs separately. Janumet improves glycemic control by three mechanisms. The dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin works on the incretin pathway to increase circulating levels of incretin hormones, said Holly S. Divine, Pharm.D., CGP, CDE, associate professor at University of Kentucky College of Pharmacy. In this way, she said, sitagliptin "increases insulin release and decreases glucagon release in a glucose-dependent manner. Metformin primarily decreases hepatic glucose production." According to Merck, the metformin component also improves insulin sensitivity by increasing uptake and utilization of glucose by muscles and tissues. Although no clinical efficacy studies were conducted with Janumet before its approval, bioequivalence with sitagliptin and metformin administered as separate tablets was demonstrated. A total of 701 patients took part in a 24-week study to evaluate the efficacy of the two drugs together. In combination with metformin, sitagliptin provided significant improvements in A1C, fasting plasma glucose, and two-hour postprandial glucose. More than twice as many patients on the combination therapy reached the A1C goal of < 7% compared with those patients on metformin alone. "There are advantages and disadvantages to combination drug therapy," Divine said. Potential advantages include taking one tablet versus two and one copayment instead of two. "D Continue reading >>

The Difference Between

The Difference Between

JANUMET tablets contain 2 prescription medicines: sitagliptin (JANUVIA®) and metformin. Once-daily prescription JANUMET XR tablets contain sitagliptin (the medicine in JANUVIA®) and extended-release metformin. JANUMET or JANUMET XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. JANUMET or JANUMET XR should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUMET or JANUMET XR. Metformin, one of the medicines in JANUMET and JANUMET XR, can cause a rare but serious side effect called lactic acidosis (a buildup of lactic acid in the blood), which can cause death. Lactic acidosis is a medical emergency that must be treated in a hospital. Call your doctor right away if you get any of the following symptoms, which could be signs of lactic acidosis: feel cold in your hands or feet; feel dizzy or lightheaded; have a slow or irregular heartbeat; feel very weak or tired; have unusual (not normal) muscle pain; have trouble breathing; feel sleepy or drowsy; have stomach pains, nausea, or vomiting. Most people who have had lactic acidosis with metformin have other things that, combined with the metformin, led to the lactic acidosis. Tell your doctor if you have any of the following, because you have a higher chance of getting lactic acidosis with JANUMET or JANUMET XR if you: have severe kidney problems or your kidneys are affected by certain x-ray tests that use injectable dye; have liver problems; drink alcohol very often, or drink a lot of alcohol in short-term “binge” drinking; get dehydrated (lose large amounts of body fluids, w Continue reading >>

Metformin And Sitagliptin (janumet)

Metformin And Sitagliptin (janumet)

are allergic to dapagliflozin or any of the ingredients in FARXIGA. Symptoms of a serious allergic reaction may include skin rash, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. If you have any of these symptoms, stop taking FARXIGA and contact your healthcare provider or go to the nearest hospital emergency room right away have severe kidney problems or are on dialysis. Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with FARXIGA Dehydration (the loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at a higher risk of dehydration if you have low blood pressure; take medicines to lower your blood pressure, including water pills (diuretics); are 65 years of age or older; are on a low salt diet, or have kidney problems Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with FARXIGA. Ketoacidosis is a serious condition which may require hospitalization and may lead to death. Symptoms may include nausea, tiredness, vomiting, trouble breathing, and abdominal pain. If you get any of these symptoms, stop taking FARXIGA and call your healthcare provider right away. If possible, check for ketones in your urine or blood, even if your blood sugar is less than 250 mg/dL Kidney problems. Sudden kidney injury occurred in people taking FARXIGA. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or excessive heat exposure Serious urinary tract infections (UTI), some that lead to hospitalization, occu Continue reading >>

Janumet Reviews & Ratings At Drugs.com

Janumet Reviews & Ratings At Drugs.com

5'-11" 294lbs 65 y.o. (taken for 2 to 5 years) January 15, 2018 For Diabetes, Type 2 "Reduced sugar level from high 12+ to 5.4 low to 7 high.In my case, side effects cause gas and diarrhea." Cosber (taken for 1 to 6 months) January 12, 2018 Did you? Yes No | Report inappropriate For Diabetes, Type 2 "I was on Metaformin for 20+ years and after the last A1c Test, doctor put on 50/850 Janumet plus FORXIGA Noticed rash on my body and need to scratch until bloody (annoying) However, not sure which medicine of the two new ones that is making me scratch my body from top to down. I'm planning to see the doctor next week" For Diabetes, Type 2 "I am a user of Janumet. It's not good that janumets packaging gives you a cut while opening its packaging since you are a diabetic thats why you are taking janumet" Did you? Yes No | Report inappropriate For Diabetes, Type 2 "Just started taking Janumet 1000 my yesterday. Luckily my daughter who studies Med at Uni read the instructions. I had a headache which she said was low blood sugar. After I ate something the headache disappeared. I have got severe diarrhea though both nights, OK in the morning???" Ted Rob (taken for less than 1 month) July 28, 2017 Did you? Yes No | Report inappropriate For Diabetes, Type 2 "I have been using Janumet 50/1000 for the past 2 yrs, No side effects and my blood sugar levels and HbA1c is below 7 and I am quite satisfied with the medicine. But the medicine is very expensive, it is on a the higher side. Manufacturer must reduce its price in India and it should be brought under Price controlled Diabetic Drugs List" Anantaram K (taken for 2 to 5 years) June 10, 2017 Did you? Yes No | Report inappropriate For Diabetes, Type 2 "This medication is overpriced rubbish. Maybe it works well for those who absolutely Continue reading >>

Comparing Diabetes Drugs: Januvia Vs. Victoza

Comparing Diabetes Drugs: Januvia Vs. Victoza

blood sugar control and lost more weight than patients who took the widely prescribed oral drug Januvia, a study shows. The trial is the first to compare two classes of diabetes drugs that target insulin-regulating hormones in the gut known as incretins, researchers say. Incretin-based drugs are most often prescribed to patients who do not achieve target blood sugar levels with the drug metformin or other oral agents for diabetes. Introduced early this year, Victoza is one of two FDA-approved drugs that mimic the activity of the naturally occurring incretin hormone GLP-1. The other is the twice-daily injected drug Byetta. Januvia works by blocking DDP-4, a key enzyme that breaks down GLP-1. Both classes of drugs increase insulin secretion and decrease secretion of the hormone glucagon, which raises blood sugar. In the new study, published April 24 in TheLancet, 665 type 2 diabetes patients who failed to achieve target blood sugar levels with metformin alone were treated with either once-daily injections of Victoza, at doses of 1.2 milligrams or 1.8 milligrams, or 100 milligrams of Januvia, taken by mouth once a day. Over 26 weeks of treatment, patients on the highest dosage of the injected drug achieved the best blood sugar control and the most weight loss. A main focus of the study was how well the two drugs lowered A1c, which measures blood sugar control over time. Nearly twice as many patients taking Victoza reached a target A1c level of less than 7%, according to study researcher Richard Pratley, MD, of the University of Vermont College of Medicine. The study was funded by Victoza manufacturer Novo Nordisk, which also participated in the study design, data collection, and data analysis. Pratley also acknowledged receiving consulting fees from both Novo Nordisk and M Continue reading >>

Janumet: Two For The Price Of One

Janumet: Two For The Price Of One

Join the fight against diabetes on Facebook FDA approval has just been given to Merks Janumet, the newest drug approved for fighting type 2 diabetes. I know, you are saying to yourself A new drug, whats the big deal? There is already Metformin and Januvia. According to Merk, the FDA approved Janumet based on clinical studies showing that Janumet packs a punch equivalent to taking both Januvia and Metformin together. Januvia and Metformin are commonly both prescribed to a type 2 diabetes patient who is having poor results from taking just one or the other. By taking one Janumet you are receiving the benefits of combining Metformin and Januvia in one convenient pill and also cutting down on your out of pocket co-pay costs. Both Janumet and Januvia represent a new class of diabetes medicines called DPP-4 which work by enhancing the bodys ability to produce insulin while also lowering elevated glucose levels. Januvia paired with Metformin is said to target all of the causes of type 2 diabetes. Janumet now makes this possible in one pill. I took a look at the Merk & Co press release which is really informative. It gives information on the clinical trials that led up to FDA approval as well as common side effects, dosing and cost. It appears that someone who is currently prescribed both Metformin and Januvia are not going to notice any additional health benefits by taking Janumet. What they will notice is that taking one Janumet pill will be more convenient as well as less costly to them. Instead of having to pay two separate co-pays each month they will pay just one. I think that not only breakthroughs in the effectiveness of type 2 diabetes medication is important but also making medication and testing more convenient. People are more likely to stay on top of medication th Continue reading >>

Compare Janumet Vs Januvia - Comprehensive Analysis By Treato

Compare Janumet Vs Januvia - Comprehensive Analysis By Treato

Diabetes Cancer COPD Alzheimer's Hepatitis C Treato does not review third-party posts for accuracy of any kind, including for medical diagnosis or treatments, or events in general. Treato does not provide medical advice, diagnosis or treatment. Usage of the website does not substitute professional medical advice. The side effects featured here are based on those most frequently appearing in user posts on the Internet. The manufacturer's product labeling should always be consulted for a list of side effects most frequently appearing in patients during clinical studies. Talk to your doctor about which medications may be most appropriate for you. The information reflected here is dependent upon the correct functioning of our algorithm. From time-to-time, our system might experience bugs or glitches that affect the accuracy or correct application of mathematical algorithms. We will do our best to update the site if we are made aware of any malfunctioning or misapplication of these algorithms. We cannot guarantee results and occasional interruptions in updating may occur. Please continue to check the site for updated information. Continue reading >>

Januvia And Janumet

Januvia And Janumet

Januvia (sitagliptin) is an oral Type 2 diabetes medication manufactured by Merck & Co. The U.S. Food and Drug Administration (FDA) approved the drug in 2006, and it is one of the most popular Type 2 diabetes drugs on the market. In 2007, the FDA approved a variation of Januvia called Janumet, which is a combination of sitagliptin and metformin. Janumet also comes in an extended-release formula called Janumet XR. Januvia and Janumet are known as dipeptidyl peptidase 4 (DPP-4) inhibitors that work by helping the body produce more insulin. Both Januvia and Janumet belong to a class of drugs called dipeptidyl peptidase 4 (DPP-4) inhibitors that work by helping the body produce more insulin. Januvia was the first DPP-4 approved by the FDA and is the top-selling brand in its class. Two million prescriptions were written for Januvia in 2011. Januvia brought in about $6 billion in 2014. Merck stands to benefit from the patent on the drug until 2022. In clinical trials, Januvia proved effective in controlling blood-sugar levels. However, some studies reported rare and serious side effects, including acute pancreatitis, severe joint pain, pancreatic cancer and thyroid cancer. How Do Januvia and Janumet Work? Januvia is designed to work with other Type 2 diabetes medications, like Byetta, to increase their effectiveness. It helps lower blood sugar in two ways. It helps the body increase insulin to stabilize blood sugar and decrease sugars that are made in the liver. It is a part of the class of diabetes medications called DPP-4 inhibitors. DPP-4 is a protein made by the body that plays a role in glucose metabolism. The process works like this: After a person eats and blood sugar rises, intestinal cells release hormones called incretin hormones. Incretin stimulates pancreatic cell Continue reading >>

Metformin (glucophage®) Versus Sitagliptin (januvia®)

Metformin (glucophage®) Versus Sitagliptin (januvia®)

The mechanism of action of metformin is completely different from that of sitagliptin. So these antidiabetic drugs work in different ways and have different safety and side effect profiles. Metformin Sitagliptin Brand name/Year of initial approval Glucophage®, 1995 Januvia®, 2006 Formulations Oral tablets, Extended-release tablets Oral tablets Drug class Antidiabetic agent Biguanide Dipeptidyl peptidase-4 (DPP-4) inhibitor Insulin secretagogue FDA-approved Indications Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus Off-label uses • Gestational diabetes • Prediabetes • Type I diabetes Mechanism of action • Decreases hepatic glucose production • Improves insulin sensitivity (increases peripheral glucose uptake and utilization) • Reduce absorption of glucose in the gut • Inhibits DPP-4 enzyme (the primary enzyme degrading the incretin hormones) resulting in prolonged active incretin levels, which regulate glucose homeostasis by increasing insulin synthesis and release from pancreatic beta - cells and decreasing glucagon secretion from pancreatic alpha-cells. Sitagliptin monotherapy requires intact ß-cells, it may be best used in people with early-stage diabetes. Metformin and sitagliptin differently influence on metabolism of glycolipids after different diets5 Half-life 6.2 hours 12.4 hours Oral bioavailability 50-60% 87% Metabolism, Elimination Metformin is not metabolized and is excreted unchanged by the kidneys 79% excreted unchanged in urine, minor metabolism Contraindications • Hypersensitivity to metformin • Metabolic acidosis • Renal dysfunction (serum creatinine levels ≥ 1.4 mg/dL or abnormal creatinine clearance) • Hypersensitivity to sitagliptin Warnings & precautions • Possible risk of Continue reading >>

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