Diabetes And Cancer
Tweet Studies have shown that diabetes carries an increased risk for a number of different forms of cancer. Having cancer with diabetes can make achieving good diabetes control much more difficult but this can be relieved to some extent. How is type 2 diabetes linked with cancer? One theory for why a link may exist is that high levels of circulating insulin (known as hyperinsulinemia) can promote the growth of tumours. In type 2 diabetes, insulin resistance commonly causes the body to produce more insulin than normal. Another reason why a link may be present is where a harmful lifestyle may lead to obesity and therefore higher risks of both type 2 diabetes and cancer. Cancer and type 2 diabetes The risks of contracting the following cancers are shown to be doubled by the presence of type 2 diabetes: Pancreatic cancer Endometrial cancer (also known as womb cancer) A smaller increased risk, of 20% to 50% is seen for the following forms of cancer. Colorectal cancer Bladder cancer Blood cancers (non-Hodgkin’s lymphoma) The one positive is that incidences of prostate cancer are actually lower for people with type 2 diabetes. Cancer and type 1 diabetes Links between type 1 diabetes and cancer are not so well recorded but it appears there is also an increase in risk of cancers for people with type 1 diabetes. The cancers with the highest increase in risk tended to be different to those noted in type 2 diabetes. The cancers with increased risk in type 1 diabetes include: Stomach cancer Cervical cancer What are the symptoms of cancer? The symptoms of cancer vary widely depending on which part of the body the cancer strikes. What treatment options are open for cancer? The main treatment options for cancer are surgery to remove the cancers or radiotherapy (also known as radiatio Continue reading >>
The Diabetes-cancer Connection
National Diabetes Awareness Month brings attention to a disease that affects nearly 30 million Americans, with another 86 million Americans at risk for developing the disease. People with diabetes have an increased risk of heart attack or stroke, kidney failure, vision loss and nerve damage. Growing evidence also suggests that people with diabetes are at higher risk for developing certain cancers, including liver , pancreatic , endometrial , colorectal , breast and bladder . Both diabetes and cancer are thought to have an inflammatory cause at the cellular level. Uncontrolled blood sugar can lead to chronic inflammation, which may cause the types of changes in cells that can increase the risk of cancer, says Carolyn Lammersfeld , Vice President of Integrative Medicine at Cancer Treatment Centers of America (CTCA). Researchers found a link between insulin resistance and cancer risk, in which high levels of insulinassociated with type 2 diabetes and prediabetesmay stimulate tumor cell proliferation and growth. Researchers also pointed to the role of high body fat, or obesity, in causing an insulin resistant state. While more research is needed to better understand the complex relationship between diabetes and cancer, we do know that a dual diagnosis is relatively common. Its estimated that as many as one in five cancer patients has diabetes as well. We also know that cancer and diabetes share many of the same risk factors. While some are uncontrollable, like aging, others are lifestyle-related, including obesity, physical inactivity and poor diet. Lammersfeld offers ways to decrease your risk of developing either disease: Achieve and maintain a healthy body weight - If youre carrying extra weight, even small amounts of weight loss can be beneficial. The Diabetes Preventi Continue reading >>
Diabetes And Cancer: What's The Connection?
When Michelle Hall was diagnosed with breast cancer two years ago, she was shocked. "The standing joke in the family was that I came from a long line of stocky French women who lived forever," says Hall, 62, of Salem, N.H. "We had no breast cancer in the family." Hall had been diagnosed with type 2 diabetes in 2001, so she would have special challenges while facing down cancer. As diseases, cancer and diabetes seem a world away from each other. Yet, numerous studies suggest the conditions are linked. People with diabetes are more likely to be diagnosed with cancer than those without diabetes, but why remains unclear. Scientists are still trying to answer even the most basic questions: Does diabetes cause cancer? If so, what kinds of cancer and how? As the interplay between diabetes and cancer becomes clearer, researchers hope to gain an edge against both diseases. The link between diabetes and cancer may be partially explained by risk factors that underlie and raise the risk of both diseases. Sex: Overall, men are more likely to develop both cancer and type 2 diabetes than women. Weight: Overweight and obese people are more likely to develop cancer than lean people. The association between type 2 diabetes and weight is also well established. While it's clear that losing weight reduces the risk for type 2 diabetes, less is known about whether weight loss combats cancer. Diet: Eating patterns that are thought to help prevent and treat type 2 diabeteslimited red and processed meats and abundant vegetables, fruits, and whole grainsare also associated with a lower risk for many types of cancer. Exercise: Studies show that regular physical activity lowers the risk of developing several types of cancer. Likewise, 30 minutes of moderate-intensity exercise per day can reduce th Continue reading >>
Type 2 Diabetes And Cancer: An Alarming Emerging Link
Home / Type 2 Diabetes / Type 2 Diabetes and Cancer: An Alarming Emerging Link Type 2 Diabetes and Cancer: An Alarming Emerging Link Type 2 diabetes can cause a number of health complications that decrease thelife expectancy of patients. Apart from causing heart disease, stroke, nerve damage, kidney disease and eye problems, research also shows that there is a connection between type 2 diabetes and cancer. For more than 50 years, physicians have been reporting cases of cancer occurring in patients with type 2 diabetes. However, the data had been inconclusive when it comes to pointing to a connection between the two conditions. In the 1960s, large population studies finally found that risks of cancer increased for people with type 2 diabetes. While relative risks imparted by diabetes for cancers of the liver and pancreas were twofold or more, the relative risks of colorectal, breast and bladder cancers were slightly lesser (1.2 to 1.5 fold.) 4 Factors That Increase The Risk of Cancer with Type 2 Diabetes While insulin is vital for glucose metabolism, more of it can be harmful to the body. Hyperinsulinemia (either due to excessive production of insulin by the body or due to injected insulin) is the root cause of increased risk of cancer among diabetics. For insulin to function as a messenger, it needs to bind to specific receptors on target cells. These receptors are present on a variety of cells. Large amounts of insulin will activate a far greater number of receptors than it should normally do. This excessive binding can create a chain of events that may lead to the cell becoming cancerous. Reduced Production of IGF-Binding Protein There is another theory that explains why hyperinsulinemia causes cancer. There is a protein in the body called Insulin-like Growth Factor Continue reading >>
What Is The Relationship Between Breast Cancer And Diabetes?
What is the relationship between breast cancer and diabetes? Survivors of breast cancer, who are post-menopausal, have a higher chance of developing diabetes. Scientists are becoming increasingly aware of an association between diabetes and cancer. In this article, we discuss the link. A study, published in Diabetologia, is the largest to observe the link between surviving breast cancer and eventually developing diabetes; it also showed that whether the patient went on to develop diabetes was closely associated with having undergone chemotherapy . The opposite interaction has also been observed: females with diabetes have a 20 percent chance of developing postmenopausal breast cancer. A study from last year demonstrated that people with diabetes over the age of 60 are more likely to develop breast cancer, compared with their counterparts without diabetes. Fast facts on breast cancer and diabetes: It has been observed that having diabetes increases the likelihood of breast cancer, and that having breast cancer increases the likelihood of developing diabetes. Lifestyle changes can help reduce risk long-term. How has the connection between breast cancer and diabetes been established? There has been increased study into the correlation of breast cancer and diabetes. The connection has been made as a result of improvements in diagnosis and treatment of breast cancer. As more women survive breast cancer, it is becoming increasingly important to understand the long-term outcomes for survivors as they grow older. However, few studies have tried to determine what the risk of developing diabetes is for a breast cancer survivor. The study in Diabetalogia is an example of the new research that has established the connection between breast cancer and diabetes more firmly. The team, Continue reading >>
Diabetes And Cancer
Diabetes and cancer are common diseases with tremendous impact on health worldwide. Epidemiologic evidence suggests that people with diabetes are at significantly higher risk for many forms of cancer. Type 2 diabetes and cancer share many risk factors, but potential biologic links between the two diseases are incompletely understood. Moreover, evidence from observational studies suggests that some medications used to treat hyperglycemia are associated with either increased or reduced risk of cancer. Against this backdrop, the American Diabetes Association and the American Cancer Society convened a consensus development conference in December 2009. Following a series of scientific presentations by experts in the field, the writing group independently developed this consensus report to address the following questions: Is there a meaningful association between diabetes and cancer incidence or prognosis? What risk factors are common to both diabetes and cancer? What are possible biologic links between diabetes and cancer risk? Do diabetes treatments influence risk of cancer or cancer prognosis? For each area, the authors were asked to address the current gaps in evidence and potential research and epidemiologic strategies for developing more definitive evidence in the future. Table 1 includes a summary of findings and recommendations. Recommendations in this report are solely the opinions of the authors and do not represent official position of the American Diabetes Association or the American Cancer Society. Go to: 1. Is there a meaningful association between diabetes and cancer incidence or prognosis? Both diabetes and cancer are prevalent diseases whose incidence is increasing globally. Worldwide, the prevalence of cancer has been difficult to establish because many area Continue reading >>
Pancreatic Cancer And Diabetes – A Cellular Case Of Chicken And Egg
We’ve all heard the age-old question about the chicken and the egg. Well scientists studying the link between diabetes (a condition where the amount of glucose in your blood is too high because the body cannot use it properly) and pancreatic cancer are facing a similar conundrum. It seems there’s a link between the two conditions, but it’s not clear which one comes first. While the majority of people with diabetes will never develop pancreatic cancer, the question of whether diabetes could be a cause or a consequence of pancreatic cancer is an important one. Answering this could help scientists better understand the biology of these two conditions, and might help spot people at higher risk of pancreatic cancer. So, as it’s pancreatic cancer awareness month, we’ve dug into the evidence to see what is known about these links, and which questions remain unanswered. We know there’s a link Doctors first started exploring the possibility of a link between diabetes and pancreatic cancer in the 1940s and 1950s. Several reports had come out saying that patients with pancreatic cancer were more likely to also have diabetes than other people. This has been shown for type 2 diabetes as well as type 1 and young onset diabetes. Since then, many studies have shown a link between the two conditions. Overall, it seems that people with diabetes are around twice as likely to be diagnosed with pancreatic cancer than the general population. And this makes sense, given that diabetes and pancreatic cancer are diseases that both affect the pancreas. The next big question is: how does this work? Does diabetes increase a person’s risk of pancreatic cancer or is it the cancer that causes diabetes? Or is there something else increasing the risk of both conditions? How pancreatic canc Continue reading >>
The Little-known Connection Between Diabetes And Breast Cancer
The Little-Known Connection between Diabetes and Breast Cancer In a hurry? Click here to read the Article Summary... Diabetes, especially lifestyle and diet-related Type 2 Diabetes, has reached epidemic proportions in the United States. And sadly not just for adults, but for children and teens as well. This is not breaking news. Still, the statistics can be scary. Close to 10% of the U.S population have been diagnosed with the disease and an estimated additional8.1 million Americans went undiagnosed in 2014, according to the Centers for Disease Control. This includes close to 4,000 new cases of Childhood Type 2 Diabetes each year (something that was unheard of just 15 years ago). And these statistics do not even include the 40% of Americans who, according to the CDC, may be deemed pre-diabetic. The Connection Between Diabetes and Cancer Is Real A study of close to one million people registered with the national Diabetes Service Scheme (NDSS) in Australia who were diagnosed between the years 1997 to 2008 discovered that there were high correlations was between Type 2 Diabetes and cancer. Specifically, these include pancreatic, liver, endometrium, kidney, thyroid and gallbladder cancer as well as certain kinds of leukemia. A 2014 report by the World Journal of Diabetes found that high correlationalso existed between Type 2 Diabetes and breast cancer as well. Increasing rates of both diabetes and cancer over the last decade has led scientists to try to determine the specific chemical and biological connections between the two diseases. For years, conventional wisdom stated that obesity was the common cause. Now more evidence points to factors related to insulin instead. There are a few connections between insulin levels and cancer. First of all, studies have shown that tu Continue reading >>
Is There A Link Between Diabetes And Pancreatic Cancer?
home / diabetes center / diabetes a-z list / link between diabetes and pancreatic cancer? article Is There a Link Between Diabetes and Pancreatic Cancer? Want More News? Sign Up for MedicineNet Newsletters! TUESDAY, Jan. 31, 2017 (HealthDay News) -- Developing or worsening type 2 diabetes could be an early sign of pancreatic cancer , new research suggests. Researchers analyzed data from nearly a million patients with type 2 diabetes or pancreatic cancer in Italy and Belgium. Half of all pancreatic cancer cases were diagnosed within a year of patients being diagnosed with diabetes , the findings showed. The investigators also found that type 2 diabetes patients whose condition deteriorated rapidly requiring more aggressive treatment were also at increased risk for pancreatic cancer . The study findings, which don't prove an association between type 2 diabetes and pancreatic cancer , were presented Monday at the European Cancer Congress (ECC) in Amsterdam. Research presented at medical meetings is typically considered preliminary until published in a peer-reviewed journal. "Doctors and their diabetic patients should be aware that the onset of diabetes or rapidly deteriorating diabetes could be the first sign of hidden pancreatic cancer, and steps should be taken to investigate it," study author Alice Koechlin said in an ECC news release. Koechlin is a research officer at the International Prevention Research Institute in Lyon, France. "There is currently no good, non-invasive method for detecting pancreatic cancer that is not yet showing any visible signs or symptoms," she said. "We hope that our results will encourage the search for blood markers indicating the presence of pancreatic cancer, which could guide decisions to perform a confirmation examination like endoscop Continue reading >>
Diabetes And Cancer: Whats The Link?
The researchers suggested that the link between the two diseases may be partly due to shared risk factors, including aging, overweight and obesity, diet, physical activity, alcohol and smoking. But its also possible that diabetes could directly affect cancer risk through metabolic abnormalities. These include excess blood sugar, insulin resistance , and high levels of insulin and related factors such as insulin-like growth factor-1 (IGF-1), which has been implicated in cancer. Chronic inflammation, which occurs in people with diabetes, may also contribute to elevated cancer risks. Some risk factors common to diabetes and cancer are modifiable; they include being overweight or obese, smoking, and lack of physical activity. Maintaining a healthy weight, not smoking, and being physically active are lifestyle measures that can reduce the risks of both diseases. The question of whether insulin and drugs taken by diabetic patients influences their risk of cancer has been raised, but the issue has not been settled. Meanwhile, the authors of the American Diabetes Association and the American Cancer Society report said that cancer risk should not be a major factor in choosing diabetes therapy. The researchers added that patients with diabetes should be strongly encouraged to undergo appropriate cancer screenings as recommended for all people of their age and sex. Continue reading >>
Diabetes And Colon Cancer: An Emerging Link
More than 25 million adults aged 20 and older in the United States have diabetes. That figure has more than tripled since 1980. That is bad news for a number of reasons. Not only can diabetes cause heart disease, stroke, nerve damage, and eye issues, but recent research now shows there is also a clear link between type 2 diabetes and colon cancer. Colon cancer is one of the most preventable types of cancer, yet it is still the third most common cancer among both men and women in the U.S. And, many of the ways people can lower their risk for colon cancer are actually the same as how they can avoid developing type 2 diabetes. These include: Staying away from a diet high in red and processed meats Keeping physically active Maintaining a healthy weight Staying away from tobacco Avoiding heavy alcohol use Even though the two diseases share several common risk factors, research shows that type 2 diabetes itself is indeed linked to increased risk of developing colon cancer. Studies also show that among patients diagnosed with colorectal cancer, those with diabetes were more likely than those without it to die – even after controlling for other factors such as disease stage, body weight, and smoking habits. There are a few major hypotheses for the link, according to Peter Campbell, Ph.D., an American Cancer Society researcher who has been studying the connection between diabetes and colon cancer for a number of years. One idea has to do with a condition that causes the amount of insulin in a person’s blood to be higher than normal, called hyperinsulinemia. Insulin is the body’s way of regulating the amount of sugar – or glucose – in the blood. Hyperinsulinemia can lead to the development of type 2 diabetes. The thought, says Campbell, is that the abnormally high level Continue reading >>
The Diabetes And Cancer Connection
Diabetic Living / Complications / Other Diabetes can increase your risks for certain cancers. Learn the actions to take now to protect your health. After 20 years of living with type 2 diabetes and a long struggle with her weight, Leila Berner got the diagnosis everyone fears: cancer. Leila, a 63-year-old rabbi who lives near Washington, D.C., never connected her diabetes and breast cancer until her doctors advised that she lose weight and get active for long-term survival. She also underwent a lumpectomy, radiation, and chemotherapy following her 2010 diagnosis. Diabetes and cancer are close cousins, and diabetes is often the first to show up. Researchers have amassed a large knowledge base on the link between diabetes and cancer, says Lesley Fels Tinker, Ph.D., RD, principal staff scientist at Fred Hutchinson Cancer Research Center in Seattle. Though questions remain, experts are sure there are several things you can do today to reduce your cancer risks. According to a 2010 consensus report published jointly by the American Diabetes Association (ADA) and the American Cancer Society (ACS), the risk of a person with type 2 diabetes developing cancer is 20-50 percent higher than a person without diabetes. Research also indicates that people with type 2 diabetes who develop cancer may experience a shorter life expectancy. That's mainly because of their existing risk or presence of heart disease and/or because many cancer treatments can harm the heart and circulatory system. Being overweight increases the odds of cancer reoccurrence. With diabetes and cancer on the rise and already the second and seventh leading causes, respectively, of death in the United States, health experts are sounding the alarm. "When people gain excess weight, they unlock a cascade of metabolic ch Continue reading >>
Why Does Diabetes Raise Cancer Risk?
More Questions Than Answers From Expert Panel on Diabetes, Cancer Link June 16, 2010 -- People with diabetes are at increased risk of certain cancers -- but why? Could it be that some diabetes treatments trigger or promote cancer ? Or do the underlying causes of diabetes also underlie cancer ? These are the questions put before an expert panel from the American Diabetes Association and the American Cancer Society (ACS). Even so, lifestyle changes that prevent or reverse diabetes will certainly cut cancer risk, says panel member Susan M. Gapstur, PhD, ACS vice president of epidemiology. "The full biologic link between diabetes and cancer has not been completely defined," Gapstur tells WebMD. "But first of all we should prevent diabetes. Then we can prevent some cancers. And for those who do have diabetes, it should be controlled as much as possible through a healthy lifestyle." Diabetes doubles the risk of liver , pancreas , and endometrial cancer . It increases the risk of colorectal, breast , and bladder cancer by 20% to 50%. But it cuts men's risk of prostate cancer . People with diabetes tend to have some known risk factors for cancer: older age, obesity , poor diet, and physical inactivity. And problems common in diabetes -- too-high insulin levels, too-high blood sugar levels , and inflammation -- increase cancer risk. "No matter what science ultimately reveals ... we already know what we need to do to lower risk for both cancer and diabetes," Alice Bender, RD, of the American Institute for Cancer Research, says in a news release. "Eat a healthy, varied, predominantly plant-based diet, be physically active every day, and maintain a healthy body weight ." Do Diabetes Treatments Raise Cancer Risk? There is evidence, but not definitive proof, that diabetes treatments Continue reading >>
Is There A Link Between Diabetes And Cancer?
Is there a link between diabetes and cancer? Diabetes and cancer have a number of common risk factors with the link between the two being considered as early as 1959. It is estimated that up to 4.6 million people are living with diabetes in South Africa and an alarming 60 000 new cases of cancers are reported annually, according to the South African National Cancer Registry. It is important to delve into the link between these two prevalent conditions in the hope that this understanding may lead to better lifestyle choices and positive changes in clinical management, says Dr Jay Narainsamy, Specialist Physician/Endocrinologist, Centre for Diabetes and Endocrinology (CDE). A report in the New England Journal of Medicine in March 2011 looked at causes of deaths in patients with diabetes. The article estimated cancer-related deaths at seven per 1000 person-years and four per 1000 person-years among men and women respectively. Diabetes was associated with an increase in cancer-related deaths involving the pancreas, ovaries, liver, colorectum, breasts, lungs and bladder, explains Dr Narainsamy. Diabetes and cancer have a number of common risk factors, some of which are modifiable and some not. Non-modifiable risk factors include age, gender and ethnicity, with increased risk for older people, men and the African American population in the United States. Modifiable risk factors include obesity, diet, physical activity, smoking and alcohol. Uncontrolled diabetes may welcome tumour growth Obesity is linked to the development of insulin resistance and type 2 diabetes. It is thought that the high levels of insulin produced by the body to compensate for insulin resistance and obesity-associated inflammation may precipitate cancer development, says Dr Narainsamy. In addition, diab Continue reading >>
Diabetes And Cancer: American Diabetes Association
Researchers are trying to learn more about the link between type 2 diabetes and certain cancers. Type 2 diabetes and certain cancers share some risk factors: Age As you get older, your risk for both type 2 diabetes and cancer goes up. Gender Overall, cancer occurs more often in men. Men also have a slightly higher risk of diabetes than women. Race/ethnicity African Americans and non-Hispanic whites are more likely to develop cancer. African Americans, Native Americans, Hispanics/Latinos, and Asian Americans/Pacific Islanders are at higher risk for developing type 2 diabetes. Overweight Being overweight can increase your risk of type 2 diabetes and certain types of cancer. Inactivity Higher physical activity levels lower the risk of type 2 diabetes and certain types of cancer. Smoking Smoking is linked to several types of cancer. Studies suggest that smoking is a risk factor for the development of type 2 diabetes. Alcohol Drinking more than one drink a day for women or two drinks a day for men raises the risk for both diabetes and cancer. Lose weight If you are overweight, even losing 7% of your weight (15 pounds if you weigh 200 pounds) can make a big difference. Use the Body Mass Index (BMI) Calculator to find out how much weight you need to lose. Eat healthy Choose a diet with plenty of: Fresh vegetables The best choices are fresh, frozen, and canned vegetables and vegetable juices without added sodium, fat, or sugar. For good health, try to eat at least 3-5 daily servings of vegetables, including asparagus, broccoli, cabbage, carrots, cauliflower, celery, eggplant, greens, peppers, snap peas and tomatoes. A serving of vegetables is cup of cooked vegetables or vegetable juice; or 1 cup of raw vegetables. Whole grains A whole grain is the entire grain, which includes Continue reading >>
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