Difference Between Apidra & Humalog
Apidra and Humalog are both types of fast-acting insulin that are used by diabetics as a bolus dose to cover the carbohydrates eaten during a meal or snack. They can both also be used in an insulin pump. While both types of insulin work to lower blood sugar quickly, certain individuals respond better to one than the other. Time Frame Ohio State University Medical Center suggests that you take Humalog insulin no more than 15 minutes after eating, but extends the amount of time you can wait to inject Apidra after a meal to 20 minutes. Onset Apidra starts working to bring down blood sugar levels 20 minutes after injection. Humalog begins lowering blood sugar 5 to 10 minutes after injection. Duration Apidra peaks (or works the hardest) between 34 and 90 minutes after injection. Humalog takes between one and two hours after injection to peak. Effectiveness Since Apidra peaks faster than Humalog, it can lower high blood sugar levels faster, meaning you spend less time with high glucose levels. This can positively impact (as in, lower) A1c test results, which measure the average blood glucose level for the past three months. Usage in Insulin Pumps Some insulin pump users have experienced fewer clogged tubing/reservoir incidents with Apidra than with Humalog. Continue reading >>
Pumping Apidra Vs Novolog
Registration is fast, simple and absolutely free so please,join our community todayto contribute and support the site. This topic is now archived and is closed to further replies. I just got a sample bottle of Apidra from my endo. I loaded it up Saturday early and I have had nothing but trouble. I've required nearly twice as much insulin to achieve the results I was used to using novolog. Your body either likes it or not. At my doctor's office there was someone in a pumping group that once Apidra came out she used 1/3 the insulin she was using. And she tried both Novolog and Humalog. For me, I have zilch difference between the three. I have just the opposite experience, I use 2/3 LESS Apidra than I did novolog. My body seems to love Apidra. I'd agree with John, eliminate other potential reaons like bad set before making a final decision. I found Apidra slightly less effective than Novorapid, and experienced some side effects. Put it aside to try again later, but haven't so far. I've used both insulins but I've only actually pumped with Apidra (I was on it when I got my pump in April last year). For me, the dose has been more or less the same. It's just the reaction time that differs (for me, Apidra has been noticably quicker with a less pronounced 'tail'). But as you can see from this thread already, individual responses do tend to vary between us all. One thing that I'm still not convinced about. I got a few problems a month or so back as I'd had a bottle out of the fridge for some time (I took it as a spare on a trip but didn't open it). So towards the end of its life it had been out of the fridge for 3-4 weeks. Either I had a bug loitering around in me or the insulin didn't take kindly to being out of the fridge for long. And I'm in the UK so even with central heati Continue reading >>
The Switch: How I Accidentally Found The Right Insulin
WRITTEN BY: Chris Wiggins Note: This article is a part of our library of resources in Tools & How to. Check out more helpful product reviews and run downs on different diabetes management devices here. One of the unfortunate realities of being a Type 1 diabetic in the American healthcare system is that we don’t always have control of the medications we receive. I’ve changed insulin back and forth from Novolog to Humalog over my time with the pump due merely to the preference of my insurance company at the time. While those two insulins were nearly identical based on my blood sugar levels, I recently was put on a new insulin for the reason that it is the only insulin my new insurance covered. That insulin is Apidra, an insulin I had never even heard mentioned by my doctors despite it being on the market since 2004. At first I didn’t know much about the new insulin, except that it was similar to Humalog, the insulin I had previously been prescribed. I was told it was slightly faster acting, but my dosages for carbohydrates and lowering my blood sugar shouldn’t change by much. While fairly skeptical about the new insulin I chose my first few meals carefully (low carbs, high fiber) and monitored my blood sugar closely. Everything seemed fine and similar to Humalog, so I figured it was just the same medicine with a new name/logo. Then after a few days I tested the insulin against a high carbohydrate sandwich from one of my favorite sandwich places. These sandwiches are not what I would call “diabetic friendly” as the bread rolls are massive, clocking in an estimated 100-120 grams of carbohydrates for my preferred roll, Dutch Crunch. What happened next was surprising. In my experience eating anything over 100 grams of carbohydrates in a single meal, I would always Continue reading >>
What Are The Possible Side Effects Of Insulin Glulisine (apidra, Apidra Opticlik Cartridge, Apidra Solostar Pen)?
APIDRA (insulin glulisine [rDNA origin]) Solution for Injection DESCRIPTION APIDRA® (insulin glulisine [rDNA origin] injection) is a rapid-acting human insulin analog used to lower blood glucose. Insulin glulisine is produced by recombinant DNA technology utilizing a non-pathogenic laboratory strain of Escherichia coli (K12). Insulin glulisine differs from human insulin in that the amino acid asparagine at position B3 is replaced by lysine and the lysine in position B29 is replaced by glutamic acid. Chemically, insulin glulisine is 3B-lysine29B-glutamic acid-human insulin, has the empirical formula C258H384N64O78S6 and a molecular weight of 5823 and has the following structural formula: APIDRA is a sterile, aqueous, clear, and colorless solution. Each milliliter of APIDRA contains 100 units (3.49 mg) insulin glulisine, 3.15 mg metacresol, 6 mg tromethamine, 5 mg sodium chloride, 0.01 mg polysorbate 20, and water for injection. APIDRA has a pH of approximately 7.3. The pH is adjusted by addition of aqueous solutions of hydrochloric acid and/or sodium hydroxide. font size A A A Type 2 diabetes: See Diabetes, type 2. Source: MedTerms™ Medical Dictionary Continue reading >>
A Comparison Of Preprandial Insulin Glulisine Versus Insulin Lispro In People With Type 2 Diabetes Over A 12-h Period.
Abstract A comparison of the plasma glucose and insulin day profiles between two prandial rapid-acting insulin analogues, insulin glulisine (glulisine) and insulin lispro (lispro), in 18 obese subjects with Type 2 diabetes. Subjects (body mass index: males, 36.7 [33.2-43.8] kg/m(2); females, 40.0 [35.7-46.5] kg/m(2)) received subcutaneous glulisine or lispro (0.15 U/kg) at 4-h intervals immediately (within 2 min) before three standard test meals during each of two 12-h, randomised, open-label, crossover studies (7+/-2-day interval between each). Overall, preprandial-subtracted glucose concentrations (area under the curve) were similar on the glulisine and lispro study days. However, the mean of the three maximal preprandial subtracted plasma glucose concentrations (DeltaGLU(max)) were lower with glulisine versus lispro (12%; p<0.01). Mean concentrations of insulin analogue were significantly higher post-meal with glulisine (p<0.01 for all). Post hoc analysis showed a significantly faster absorption rate for glulisine versus lispro in the first 30 min post-meal (estimated difference 0.48 microU/min; p<0.0001). Only two cases of hypoglycaemia were reported; both from one subject during the lispro day. When glulisine is injected immediately before a meal in obese patients with Type 2 diabetes, glulisine achieves significantly lower glucose excursions over lispro. Significantly faster absorption with higher and sustained post-meal levels of insulin analogue was achieved at every meal with glulisine versus lispro. Continue reading >>
Similarities And Differences Between Apidra Insuin Vs Humalog
Apidra and Humalog are both injectable insulins that are used to treat people with diabetes. These drugs help to reduce high blood sugar levels in people with type 1 and type 2 diabetes. Both insulin medications are fast-acting insulin analogs, meaning that they start to work quickly compared to other insulin analogs. However, there are differences between them, hence they cannot be used interchangeably. If your doctor prescribes either Apidra or Humalog, you may need to take them together with long-acting insulin. What is Apidra? Apidra is a fast-acting insulin that has insulin glulisine. Insulin glulisine starts to work after 15 minutes and peaks after 1 hour. As a fast-acting insulin, it is recommended you take this medication 15 minutes before you eat, or 20 minutes after you eat. This medicine is only part of a treatment program which includes a diet plan, an exercise program, weight control and blood sugar testing. Your blood sugar will be affected in case you change any of these factors. It is used to treat adults with type 2 diabetes and type 1 diabetes in adults and children above the age of 4. However, the drug should not be taken by children younger than the age of 4. What is Humalog? Humalog refers to another fast-acting insulin which is taken by people with diabetes to lower blood sugar levels. When injected under the skin, the medication starts to work after 15 minutes to lower your blood sugar levels. If you take this insulin drug with a meal, you should take it within 15 minutes before you eat or just after you take a meal. This medication should be used as it is prescribed by your doctor. Make sure you carefully follow the instructions on the prescription label. It should not be used to treat children of any age with type 2 diabetes. Similarities and di Continue reading >>
Switching From Novolog To Humalog
Looks like Ill be switching insulins, due to new Rx coverage, effective in January 2018. My endo has said they are essentially the same, but I thought Id check in here. Also on Lantus, but that will stay the same. Doing MDI with a CGM right now. I think there are minor differences that can be noticeable for some people. I tried Humalog briefly and found that I needed much more of it for carbs and corrections, that I had to increase my basal rates (I was using it in a pump) and that it didnt last as long. My son has not used Humalog, but Ive heard the same as @Scott_Eric . Calebs endo discourages its use bc of experience hes seen with pumping - it being more susceptible to clogging. Any chance your insurance is Aetna? We got a similar notice. I made that switch and didnt notice much of a differenceI think humalog may be a tiny bit faster/have less of a tail, but hard to say. Im also on MDI (humalog and tresiba, formerly lantus), so the clogging/pumping concern wasnt an issue. I used NovoLog for years and Ive used Humalog for years. I dont see any functional difference between the two. I have noticed on the internet some people claim they find difference between the two. If thats true its now a your mileage may vary issue Ive used both. I need about 12% more insulin on Humalog than on Novolog on MDI. But in a previous thread on a different message board, I noted that there were others who had the opposite experience. Also Humalog gets started a little faster than Novolog for me and at least in previous years had a slightly shorter tail. However, this year Ive noticed that a typical mealtime dose (8 units) of Humalog takes between five and six hours to finish working, which is as long as Novolog took the last time I was on it about three years ago.It may be just that at m Continue reading >>
Short Acting Insulin Analog
Apidra (Insulin glulisine), Novo Rapid (Insulin Aspart) and Humalog (Insulin Lispro) are rapid acting analog insulins produced by recombinant DNA technology. They are chemically identical to human insulin except that: in Novo Rapid the amino acid Proline has been substituted for aspartic acid at position B28 of the insulin molecule. In Humalog the location of the 2 amino acids lysine and proline have been changed. These structural changes give Novo Rapid and Humalog a much more rapid onset of action and a shorter duration of action than regular insulin. Regular Insulin has an onset of action about 1 hour after injection and the effect peaks in 4 hours and lasts 6 hours. Novo Rapid, Apidra and Humalog have similar action profiles – with an onset of action about 30 minutes after injection and a peak effect at 1 hour with essentially no effect 2-3 hours after injection. Blood glucose starts to rise less than 30 minutes after a meal, thus Novo Rapid, Apidra and Humalog are able to deal with this glucose rise earlier than Regular Insulin. As expected, there is less hyperglycemia 1 or 2 hours after a meal than there is using Regular Insulin and there is less hypoglycemia 3 to 4 hours after a meal than with Regular Insulin. In other words the action of Novo Rapid, Apidra or Humalog is closer to the action of food and they are therefore effective insulins to take with meals. Novo Rapid, Apidra and Humalog may be used in Intensive Insulin Treatment Routines in which Insulin is given with each meal and it may also be used in an insulin pump. Novo Rapid and Humalog are supplied in 10 mL vials for administration with a syringe or 3 mL cartridges. Apidra is supplied in 10 ml vials or 3 ml disposable Solostar pen. Humalog cartridges fit into the Humapen Luxura, supplied by Lilly. N Continue reading >>
Effect Of Apidra Compared To Humalog In Decreasing Post-prandial Hyperglycemia
This study aims to compare the post-meal blood glucose values of two drugs in a "real-world‟ setting. This is a randomized, open-label trial that aims to compare the glycemic excursion following food intake following post-meal injection of Glulisine (Apidra) insulin and Lispro (Humalog) insulin in a real-world setting. Children participating in the Florida Camp for Children and Youth with Diabetes will be randomized to receive either Glulisine or Apidra to cover carbohydrates after meals. The difference in blood glucose values will be analyzed before and 2 hours after meals to see if there is a difference in post-prandial hyperglycemia between groups. Study Type : Interventional (Clinical Trial) Actual Enrollment : 107 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Supportive Care Official Title: Comparison of Effectiveness of Glulisine and Lispro in Decreasing Post-Prandial Hyperglycemia in a Real-World Setting Study Start Date : June 2011 Primary Completion Date : August 2012 Study Completion Date : August 2012 Resource links provided by the National Library of Medicine U.S. FDA Resources Arm Intervention/treatment Active Comparator: Humalog Subjects on this treatment arm will receive Humalog insulin for their bolus doses, with doses optimized individually to achieve glycemic targets at daily medical rounds with their cabin physicians. Drug: Humalog Subjects on this treatment arm will receive Humalog insulin for their bolus doses, with doses optimized individually to achieve glycemic targets at daily medical rounds with their cabin physicians. Other Name: Insulin lispro Active Comparator: Apidra Subjects on this treatment arm will receive Apidra insulin for their bolus doses, with doses optimiz Continue reading >>
- The Effect of Walking on Postprandial Glycemic Excursion in Patients With Type 1 Diabetes and Healthy People
- Advice to walk after meals is more effective for lowering postprandial glycaemia in type 2 diabetes mellitus than advice that does not specify timing: a randomised crossover study
- Why Isn't Postprandial Insulin Assay Being Used to Predict Diabetes Onset?
Humalog Vs Novorapid
Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community i'm currently on humalog (and lantus), but it doesn't seem to "kick in" as quickly as it should do... i've been rotating the injection site just incase that was the problem, but it still doesn't seem as instant as it should be, and my sugars will be high for about an hour (or two!) after i eat before it seems to start working - especially in the mornings, which can't be right..? someone told me that novorapid had a slightly faster and longer peak action time, is that right? if so, that could be better for me than the humalog? and are there any other differences between them? - i'd ask my "handy diabetes nurse" but i still don't have one!! Humalog is supposed to have an effect after approx 15 mins, peak activity around 1 hrs and a duration of about 2 - 5 hrs. Novorapid is supposed to have an effect after approx 10-20 mins, peak activity around 1-3 hrs and a duration of about 3-5 hrs. Here's a link to various Insulin profiles which I posted in another thread : I use Apidra which seems to work very quickly and then leave my system very quickly - sometimes a little too quickly as the two-hour reading can be brilliant (or a little low on occasions), but a three-hour reading can show my BG rising a bit as the slow-release carbs can hit me after the Apidra action has finished :roll: (This seems to happen particularly when I eat egg noodles). Another member has advised me to split the dose, which I will try. The good thing with Apidra is that I can take it immediately after my meal and it's still effective - so I know how much I've eaten when I take it, instead of guessing how much I might eat! As for Humalog and Novarapid, it's interesting that many people o Continue reading >>
Humalog Vs. Novolog.
It wasn't until recently that I started thinking about building up a tolerance to insulin. Do you build up a chemical familiarity, a resistance of sorts, to a drug after taking it for ... oh, say a few decades? Do PWD eventually become the Dread Pirate Roberts, building up a tolerance to iocane powder? "I realize this is probably ridiculous, and I'm sure there aren't any studies on this," I said to my doctor the other week. "But it has prompted me to want to try a different kind of fast acting insulin, to see if I have better results. Is that something I'm able to do, to have a script written for a one-off in order to assess how the insulin might work for me?" "We can do that." And I left the appointment, expecting my pharmacy to auto-dial me when my order was complete. Instead, a three-month supply of Novolog ended up on my doorstep, having been accidentally shuttled through my mail order pharmacy and eating up my insurance order that was intended for my normal course of Humalog. Which is why I'm experimenting with Novolog for the next few months, as a result of a shipping error. I've been taking Humalog for over ten years, after switching from Regular insulin before starting on my insulin pump, so I feel like I'm familiar with how Humalog acts in my pump and on my blood sugars. Switching to a different, but similar, rapid-acting analog should hopefully be a seamless transition. Last night was my first pump-load of Novolog, despite the last unopened bottle of Humalog in my stash. (I didn't want to use up the Humalog entirely, then switch to Novolog, because if I absolutely hated the new insulin, I'd be stuck with it.) So far, last night was entirely uneventful, and the biggest change I've noticed (in less than 24 hours of use) is that the bottle of Novolog plays host t Continue reading >>
Novorapid - Could Switching To Apidra Or Humalog Offer Some Benefit?
Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community Novorapid - Could switching to Apidra or Humalog offer some benefit? (If you've experienced more than one) Which type of rapid acting insulin works the quickest for you? After a long time waiting I've finally been able to begin pump therapy, I've experienced a great increase in control despite it being early days and "starting again". Before my main problems were: A very erratic and unpredictable basal rate that would still result in night-time hypos, which meant I had to cut out basal over-night altogether. My body digesting carbohydrates/proteins/fat extremely quickly (insulin not beginning to make a dent sometimes up to 23 hours after a meal) resulting in huge spikes unless I did my insulin a long time before the meal. Having to suddenly stop a highly active life-style/exercise routine due to hypos and other problems (despite carb-counting religiously, injecting temp basal/bolus to accomodate varying levels of activity). Not being able to eat certain types of carbohydrate without experiencing nasty spikes- in my case this has been bread, potato and pasta in that order. I've noticed rice sits with me a bit better regardless of white/brown. Low GI as expected sits with me better. To get the idea/ to see some figures showing my general control please view this thread. Since beginning pump therapy, my basal has been incredibly stable and predictable most of the time but I still have a long way to go before having a fine tuned regime. This as a result has alleviated the other problems in some ways- the main one for me being able to go to sleep without fearing hypo and/or waking up with ridiculously high readings. I've had some extreme problems today aga Continue reading >>
Compare Humalog Vs. Apidra
Apidra (insulin glulisine) is an insulin that controls blood sugar during your meals, but you'll still have to follow your doctor's diet and exercise plan. Humalog (insulin lispro) is the most effective medication for lowering your blood sugar. Dose can be easily adjusted to create a regimen that's tailored to your body's needs. Humalog (insulin lispro) can be used even if you have liver or kidney problems, unlike other anti-diabetic medications. Apidra (insulin glulisine) starts working in as soon as 15 minutes. Programs are available to lower your copay. Talk to your doctor or pharmacist. Can be used in people over 65 and children 4 years of age and older. 280 reviews so far Have you used Humalog (insulin lispro)? Leave a review Not enough review data. Continue reading >>
Different Insulins Are Designed For Different Needs.
Prescription Apidra® is for adults with type 2 diabetes or adults and children (4 years and older) with type 1 diabetes to improve blood sugar control. Apidra® given by subcutaneous injection is usually used with a longer-acting insulin. When used as a mealtime insulin, Apidra® should be given within 15 minutes before or within 20 minutes after starting a meal. Apidra® may be infused subcutaneously by external insulin infusion pumps. Do not use Apidra® during a low blood sugar reaction (hypoglycemia) or if you are allergic to any of the ingredients in Apidra®. Do not share needles, insulin pens or syringes with others. Do NOT reuse needles. You must test your blood sugar levels while using insulin, such as Apidra®. Do not make any changes to your dose or type of insulin without talking to your healthcare provider. Any change of insulin should be made cautiously and only under medical supervision. Apidra® must only be used if the solution is clear and colorless with no particles visible. Apidra®, when given by injection under the skin, should not be mixed with insulins other than NPH. Do not mix Apidra® with any insulin when used in the pump or for intravenous administration. The most common side effect of insulin, including Apidra®, is low blood sugar (hypoglycemia), which may be serious. Some people may experience symptoms such as shaking, sweating, fast heartbeat, and blurred vision. Severe hypoglycemia may be serious and life threatening. It may cause harm to your heart or brain. Other possible side effects may include low blood potassium, injection site reactions, such as changes in fat tissue at the injection site, and allergic reactions, such as itching and rash. Less common, but potentially more serious or life-threatening, is generalized allergy to in Continue reading >>
Rapid-acting Analogues
Rapid-Acting Analogues Short-Acting Insulins Intermediate-Acting Insulins Long-Acting Insulins Combination Insulins Onset: 12 - 18 min Peak: 1-3 hours Duration: 3-5 hours Solution: Clear Comments: NovoLog should generally be given immediately before a meal (start of meal within 5-10 minutes after injection) because of its fast onset of action. NovoLog is homologous with regular human insulin with the exception of a single substitution of the amino acid proline by aspartic acid in position B28 (beta chain). Insulin lispro (Humalog) and insulin aspart (Novolog), when administered intravenously, show pharmacodynamic parameters similar to regular insulin. Mixing NPH: If NovoLog is mixed with NPH human insulin, NovoLog should be drawn into the syringe first. The injection should be made immediately after mixing. Regular insulin: Compatible - but NO support clinically for such a mixture. Draw up Novolog first before drawing up Regular Insulin. Mixtures should not be administered intravenously. When used in external subcutaneous infusion pumps for insulin, NovoLog should not be mixed with any other insulins or diluent. When rapid-acting insulin is mixed with either an intermediate- or long-acting insulin, the mixture should be injected within 15 min before a meal. INDICATIONS AND USAGE Treatment of Diabetes Mellitus NovoLog is an insulin analog indicated to improve glycemic control in adults and children with diabetes mellitus. DOSAGE AND ADMINISTRATION Dosing NovoLog is an insulin analog with an earlier onset of action than regular human insulin. The dosage of NovoLog must be individualized. NovoLog given by subcutaneous injection should generally be used in regimens with an intermediate or long-acting insulin [see package insert for Warnings and Precautions (5), How Supplied Continue reading >>
