I'm maxed out on metformin (850 mg 3x/day) and glyburide (5mg 4x/day). Januvia, even without the other 2 meds, had my readings in the desired ranges in a day. It's only been 5 days, but so far VERY GOOD! Thanks! Started Januvia 100 mg once a day with in days I had joint pain so bad I did not want to get out of bed and the join pain has not went away its not as bad but still there. Chronic heart pain my heart beat so hard and fast I worried I was having a heart attack. My chest was/is sore I have congestion, I still have a fast heart beat off and on "This worries me". Shortness of breath. I was dizzy, chest colds, Very bad headache, Both hands were numb this was worse at night I would wake with my hands hurting I still have some numbness it is off and on and and mostly in my fingers now. I was so hoping Januvia would work for me. I do not think this drug was not tested well enough before the public was allowed to use it. I hope my side effects are not long term and no damage was caused and with time will go away. I was on another medication for type 2 diabetes and it didnot work for me. My doctor didn't want to take me off of it because he said it work for most people. Well, I change Doctors and the new Doctor stated me on Januvia 50 mg in the AM and 50 in the PM and it started to work at the end of the week, no side effects, my number was very close to normal and I feel GREAT . I even lost weight while on this medication. My husband is on 50 mg a day and doing great with no side effects. Family member had a rash with this medicine, and a friend said there was a new warning posted about a deadly disease called Stevens-Johnson syndrome associated with Januvia. I didn't find it in WebMd though. Is it true? Januvia (with metformin) has worked very well for me so far (3 mont Continue reading >>
Yet Another Problem With Januvia
UPDATE (April 2, 2013): Before you take Byetta, Victoza, Onglyza, or Januvia please read about the new research that shows that they, and probably all incretin drugs, cause severely abnormal cell growth in the pancreas and precancerous tumors. You'll find that information HERE. Update (January, 2009) : A much more important problem with Januvia--that it promotes cancer by inhibiting a tumor suppressor gene researchers have called "the trigger for prostate cancer"--is discussed in this more recent blog post: More Research Shows Januvia and Glinides Inhibit Tumor Suppressor Gene DPP-4. Posted Dec 8, 2008. Original Post: If you have had or might get melanoma, ovarian cancer, lung cancer or prostate cancer, please read the above post before making your decision about whether Januvia is for you. Here is the original post that was posted 9/12/08: I have been hearing from people about a new, and, to me, very troubling problem with Januvia. The problem is this: now that doctors have decided that all people recently diagnosed with Type 2 Diabetes should be put on Januvia, prescriptions for the combination drug Janumet, which is made up of both Januvia and Metformin, are becoming much more frequent as a first prescription for diabetes. Metformin is a very safe drug that has been used safely for decades. The most recent follow up to the UKPDS study, the 20 year follow-up, which was just presented at the annual EASD conference found that at 20 years after the start of the study, "Patients treated with metformin had a 21% reduction in risk of any diabetes endpoint (P=0.01), a 30% reduction in risk of diabetes-related death (P=0.01), a 33% reduction in risk of MI (P=0.005), and a 27% reduction in risk of all cause mortality (P=0.002)." Metformin is a very good drug for people with Ty Continue reading >>
Lowers Your Blood Sugar.
Our bottom line Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine. Oral blood sugar-lowering medicine. Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class. It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines. Lowers A1c (average blood sugar over time) by less than 1%. Rare but serious side effects include pancreatitis and severe joint pain. Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin. Sign up and get Pill Talk, the latest in health & medicine news from Iodine What to expect when you take Januvia (sitagliptin) for Type 2 diabetes Possible side effects Source: FDA product label and Iodine pharmacists Side effect rates for Januvia (sitagliptin) Where we got our data » Risks and Warnings for Januvia (sitagliptin) Higher risk if: › History of pancreatitis › High blood triglyceride levels › Gallstones (stones in gallbladder) › History of alchoholism › Kidney problems Januvia (sitagliptin) can cause a sudden inflammation of the pancreas. This can be life-threatening if not treated. Let your doctor know about any stomach pain, nausea, vomiting, or loss of appetite that doesn't go away. Frequently Asked Questions This medication treats type 2 diabetes in adults. Common concerns from people taking Januvia (sitagliptin) Take once a day in the morning with or without food. Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function. Tell your doctor right away if you have severe stomach pain, Continue reading >>
How Does Januvia Work In Your Body?
JANUVIA (jah-NEW-vee-ah) is a once-daily prescription pill that, along with diet and exercise, helps lower blood sugar levels in adults with type 2 diabetes. JANUVIA should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUVIA. Serious side effects can happen in people who take JANUVIA, including pancreatitis, which may be severe and lead to death. Before you start taking JANUVIA, tell your doctor if you've ever had pancreatitis. Stop taking JANUVIA and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis. Before you start taking JANUVIA, tell your doctor if you have ever had heart failure (your heart does not pump blood well enough) or have problems with your kidneys. Contact your doctor right away if you have increasing shortness of breath or trouble breathing (especially when you lie down); swelling or fluid retention (especially in the feet, ankles, or legs); an unusually fast increase in weight; or unusual tiredness. These may be symptoms of heart failure. Do not take JANUVIA if you are allergic to any of its ingredients, including sitagliptin. Symptoms of serious allergic reactions to JANUVIA, including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing, can occur. If you have any symptoms of a serious allergic reaction, stop taking JANUVIA and call your doctor right away. Kidney problems, somet Continue reading >>
Januvia Deemed Safe For People With Type 2 Diabetes At Risk Of Heart Problems, Study Says
Januvia deemed safe for people with type 2 diabetes at risk of heart problems, study says Januvia deemed safe for people with type 2 diabetes at risk of heart problems, study says Link found between higher mole count and increased type 2 diabetes risk 06 January 2017 A commonly prescribed drug to treat type 2 diabetes drug called Januvia (sitagliptin) is safe for use in older people who may be at risk of cardiovascular problems, a study reports. People with type 2 diabetes are more prone to suffer from cardiovascular problems because of an increased risk of high blood pressure , heart disease and stroke . In this new analysis, researchers at the Oxford Centre for Diabetes found sitagliptin, a relatively new drug, raised "no significant safety concerns" in people with type 2 diabetes . The study, entitled TECOS (Trial Evaluating Cardiovascular Outcomes With Sitagliptin), collected data from more than 14,000 people aged 50 years or over who had type 2 diabetes and a history of cardiovascular problems. The researchers focused on 14 per cent of the participants who were aged 75 and in the oldest age group. The group had HbA1c levels of at least 6.5% but not higher than 8%. "Among older patients with well-controlled type 2 diabetes and cardiovascular disease, sitagliptin had neutral effects on cardiovascular risk and raised no significant safety concerns," said the authors. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor which helps to increase insulin in the body by decreasing the amount of sugar. It is usually taken alongside a healthy diet and regular exercise , and can be used alongside other type 2 diabetes drugs such as metformin . Cardiovascular disease is caused when blood vessels are damaged which can be caused by smoking , high sugar levels or unbalanced Continue reading >>
What is it used for? Januvia can be used on its own to improve blood sugar control in people whose blood sugar is not controlled by changes to their diet and exercise alone and who can't take metformin. Januvia is also used for people with type 2 diabetes whose blood sugar is not sufficiently controlled by other antidiabetic medicines. It can be added to treatment with metformin, a sulphonylurea (for example gliclazide) or another type of antidiabetic medicine known as a thiazolidinedione (for example pioglitazone or rosiglitazone). It can also be used for people who are using insulin. How does it work? Januvia tablets contain the active ingredient sitagliptin, which is a type of medicine called a dipeptidyl peptidase 4 (DPP-4) inhibitor. It is used to treat people with type 2 or non-insulin dependent diabetes (NIDDM). Sitagliptin works by increasing the amount of two incretin hormones found in the body, called glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). These hormones are normally produced naturally by the body in response to food intake. Their function is to help control blood sugar (glucose) levels. GLP-1 and GIP have four main actions that help to control blood glucose. Firstly, they stimulate the pancreas to produce insulin in response to increasing levels of glucose in the blood. (Insulin is the main hormone responsible for controlling sugar levels in the blood. It causes cells in the body to remove sugar from the blood.) GLP-1 also reduces the production of glucagon. (Glucagon is a hormone that normally increases glucose production by the liver.) GLP-1 and GIP also reduce the rate at which food passes from the stomach into the intestines, which slows down the absorption of glucose from the gut into the bloodstream. Finally, Continue reading >>
Get your ringside seats, Folks! A while back I posted about the Merck's new Type 2 oral drug Januvia (What It Doesn't Do), explaining how it apparently trumps competitors in terms of patient "tolerability." No other post has ever generated such ongoing reader energy, both positive and negative. Nearly every day, several new commentors weigh in, duking it out over the relative merits of Januvia. Most everyone seems to agree that Januvia reduces appetite, which is a good thing. But then again, Byetta is known for that effect as well. The key is question whether Januvia fulfills its core function of lowering blood glucose (BG) levels, and lives up to its no-side-effects promise. As of today, the score stands pretty much tied, as such: Total comments = 50 Positive = 10 Negative = 13 Mixed = 16 (liked some aspects of the drug but not others) Neutral = 11 (those asking or responding to questions only) Among the most vocal of the Pro Team: "I take Januvia and have for 6 months. I have no side effects. I have experienced a decrease in appetite. I have had no headaches or respiratory problems. My BG has gone down. It is a great drug." -- Mike "Januvia has been a positive thing for me. My sugar levels dropped from 240+ to 110 +/- 10 after fasting. I have taken 100 mg once per day for a month... I am not as hungry as before usage." -- Jim K. L. "I've been on Januvia for a little over three months and have lost over 15 pounds which I had put on with Actos. I've experienced no side effects, other than I am not hungry all of the time. For me it has been very effective..." -- Bill "I am substantially less hungry then I have felt in years ... and my BG hovers around 100 - 120 between meals/fasting, and 120 - 160 for a few hours after a heavy carb meal. The usual BG spikes of 180 - 200+ Continue reading >>
What Are The Possible Side Effects Of Sitagliptin (januvia)?
A A A Medications and Drugs Brand Names: Januvia Generic Name: sitagliptin (Pronunciation: SI ta glip tin) What is sitagliptin (Januvia)? Sitagliptin is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating. Sitagliptin is for people with type 2 diabetes. Sitagliptin is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes. Sitagliptin may also be used for purposes not listed in this medication guide. What are the possible side effects of sitagliptin (Januvia)? Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking sitagliptin and call your doctor at once if you have a serious side effect such as: pancreatitis - severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, fast heart rate; or urinating less than usual or not at all; swelling, weight gain, feeling short of breath; or severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. Less serious side effects may include: runny or stuffy nose, sore throat; headache, back pain, joint or muscle pain; or This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What is the most important information I should know about sitagliptin (Januvia)? Do not use this medication if you are allergic to sitagliptin or if you are in a state of diabetic ketoa Continue reading >>
Januvia And Janumet
Januvia (sitagliptin) is an oral Type 2 diabetes medication manufactured by Merck & Co. The U.S. Food and Drug Administration (FDA) approved the drug in 2006, and it is one of the most popular Type 2 diabetes drugs on the market. In 2007, the FDA approved a variation of Januvia called Janumet, which is a combination of sitagliptin and metformin. Janumet also comes in an extended-release formula called Janumet XR. Januvia and Janumet are known as dipeptidyl peptidase 4 (DPP-4) inhibitors that work by helping the body produce more insulin. Both Januvia and Janumet belong to a class of drugs called dipeptidyl peptidase 4 (DPP-4) inhibitors that work by helping the body produce more insulin. Januvia was the first DPP-4 approved by the FDA and is the top-selling brand in its class. Two million prescriptions were written for Januvia in 2011. Januvia brought in about $6 billion in 2014. Merck stands to benefit from the patent on the drug until 2022. In clinical trials, Januvia proved effective in controlling blood-sugar levels. However, some studies reported rare and serious side effects, including acute pancreatitis, severe joint pain, pancreatic cancer and thyroid cancer. How Do Januvia and Janumet Work? Januvia is designed to work with other Type 2 diabetes medications, like Byetta, to increase their effectiveness. It helps lower blood sugar in two ways. It helps the body increase insulin to stabilize blood sugar and decrease sugars that are made in the liver. It is a part of the class of diabetes medications called DPP-4 inhibitors. DPP-4 is a protein made by the body that plays a role in glucose metabolism. The process works like this: After a person eats and blood sugar rises, intestinal cells release hormones called incretin hormones. Incretin stimulates pancreatic cell Continue reading >>
Do Januvia Side Effects Include Cancer Of The Pancreas?
Q. My wife is taking Januvia to control her blood sugar. Without Januvia her sugar level is 130 or more. With Januvia it is in the range of 110, which is close to normal. I heard an interview on the radio that three medications to reduce blood sugar levels may have negative side effects, including cancer of the pancreas. Now I am wondering what is worse, pancreatic cancer or the effect of excessive sugar level in the blood. Our “medicine man” told my wife not to worry about side effects with Januvia. I have my doubts now and would welcome your thoughts. A. The story is quite complicated. Januvia (sitagliptin) belongs to a class of diabetes drugs called incretin mimetics. Incretin is a natural hormone produced by the body. It helps stimulate the pancreas to release insulin after a meal which leads to lower blood sugar levels. This category of medications mimics incretin. They include DPP-4 (dipeptidyl peptidase 4) inhibitors and GLP-1 agonists. That’s short hand for glucagon-like peptide-1 receptor agonists. Sorry for the hard-to-pronounce alphabet soup. But wait, it gets worse! The generic names for such drugs are also difficult to pronounce: Alogliptin (Nesina, Oseni) Exenatide (Byetta) Linagliptin (Tradjenta) Liraglutide (Victoza) Saxagliptin (Onglyza) Sitagliptin (Januvia, Janumet) Vildagliptin (Galvus) They have been extremely popular with diabetes doctors because they generally produce good numbers. That is to say they control blood glucose levels quite well and are often considered “well tolerated.” In other words, the medical community considers them as having few side effects. What About the Pancreas? Remember that these incretin mimetics work by stimulating the pancreas to make more insulin. A study published in the journal JAMA Internal Medicine (Apr Continue reading >>
Mercks Once-weekly Diabetes Pill Is As Good As Januvia In Study
Mercks Once-Weekly Diabetes Pill Is as Good as Januvia in Study Drugmaker plans to file drug with the FDA by the end of year Pill could help Merck in highly competitive diabetes market Merck & Co. s experimental, once-a-week diabetes drug was as effective at regulating blood sugar as its top-selling daily pill Januvia, according to a study the company will submit to U.S. regulators this year as part of its effort to get the treatment approved. In a study of 642 patients with type 2 diabetes, patients who took the once-a-week drug, omarigliptin, reduced their blood sugar to similar levels as those taking Januviaafter 24 weeks. Blood sugar is a key measure of how well a patients diabetes is being controlled. Other studies of omarigliptin, including a large trial to assess the drugs effect on patients likelihood of having a heart attack or other cardiac event, are still ongoing. For Merck, a successful once-a-week medicine could help the company fight back against competitors that are chipping away at the Kenilworth, New Jersey-based drugmakers dominance of the market for brand-name diabetes pills. Last month, Eli Lilly & Co. and Boehringer Ingelheim GmbHs pill Jardiance was shown to help prevent heart attacks, strokes and deaths from heart disease in high-risk patients. That result -- the first for any diabetes drug -- could threaten Januvias position as the pill of choice for patients who cant get their diabetes under control with metformin, a cheap generic drug thats usually the first step in therapy. In a study earlier this year, Merck showed that Januvia didnt increase patients heart risks when compared with a placebo. "For some patients, a once-weekly is a nice option,"Peter Stein, Mercks vice president of diabetes and endocrinology research, said in an interview. " Continue reading >>
are allergic to dapagliflozin or any of the ingredients in FARXIGA. Symptoms of a serious allergic reaction may include skin rash, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. If you have any of these symptoms, stop taking FARXIGA and contact your healthcare provider or go to the nearest hospital emergency room right away have severe kidney problems or are on dialysis. Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with FARXIGA Dehydration (the loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at a higher risk of dehydration if you have low blood pressure; take medicines to lower your blood pressure, including water pills (diuretics); are 65 years of age or older; are on a low salt diet, or have kidney problems Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with FARXIGA. Ketoacidosis is a serious condition which may require hospitalization and may lead to death. Symptoms may include nausea, tiredness, vomiting, trouble breathing, and abdominal pain. If you get any of these symptoms, stop taking FARXIGA and call your healthcare provider right away. If possible, check for ketones in your urine or blood, even if your blood sugar is less than 250 mg/dL Kidney problems. Sudden kidney injury occurred in people taking FARXIGA. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or excessive heat exposure Serious urinary tract infections (UTI), some that lead to hospitalization, occu Continue reading >>
Januvia Side Effects Center
Januvia (sitagliptin) is an oral diabetes medicine for people with type 2 diabetes (non-insulin-dependent) diabetes. Januvia is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes. Many people using Januvia do not have serious side effects. Side effects that may occur with Januvia include: headache, joint or muscle pain, nausea, stomach pain, diarrhea, or constipation. Although Januvia by itself usually does not cause low blood sugar (hypoglycemia), low blood sugar may occur if Januvia is prescribed with other anti-diabetic medications. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. Tell your doctor if you have serious side effects of Januvia including pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, fast heart rate), urinating less than usual or not at all, swelling, weight gain, shortness of breath, or severe skin reaction (fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads [especially in the face or upper body] and causes blistering and peeling). The recommended dose of Januvia is 100 mg once daily. Januvia may interact with digoxin, probenecid, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), or beta-blockers. Tell your doctor all prescription and over-the-counter medications you use. During pregnancy Januvia should be used only when prescribed. Pregnancy may cause or worsen diabetes. Your doctor may change your diabetes treatment during pregnancy. It is unknown if this drug passes into breast milk. Cons Continue reading >>
Some Disturbing News About Januvia
UPDATE (April 2, 2013): Before you take Byetta, Victoza, Onglyza, or Januvia please read about the new research that shows that they, and probably all incretin drugs, cause severely abnormal cell growth in the pancreas and precancerous tumors. You'll find that information HERE. NEW Dec 19, 2008: If you want to better understand the health issues associated with Januvia, read the Dec 8, 2008 blog post citing the research that makes it clear that a "side effect" of how Januvia lowers blood sugar is that it turns off a tumor suppressor gene making it "a trigger for prostate cancer". This same mechanism has been linked with promoting melanoma, ovarian cancer and lung cancer. None of the approval testing for Januvia investigated this problem and there is evidence it is real and affecting people taking this drug. You can read about this important issue here: More Research Shows Januvia and Glinides Inhibit Tumor Suppressor Gene DPP-4 Here is the original post "Some Disturbing News About Januvia": Diabetes in Control reports last week that "According to a survey, prescriptions for the diabetes drug Januvia have grown nearly threefold between the first week of 2007 and the week ending July 20. ... It was reported that patients were switched from metformin 21%, Avandia 17% and Actos 13%." Once again we are being treated to the spectacle of doctors who do not understand a new drug's mode of action prescribing that new drug in a way that is guaranteed to damage the health of many of those patients. Januvia does NOT affect Insulin Resistance Januvia stimulates insulin production after meals and may inhibit the production of glucagon after meals. That's what it does folks, and that is ALL it does. The problem here is that for at least 21% of the Type 2s in this study, doctors were t Continue reading >>
What Is Januvia
JANUVIA (jah-NEW-vee-ah) is a once-daily prescription pill that, along with diet and exercise, helps lower blood sugar levels in adults with type 2 diabetes. JANUVIA should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUVIA. IMPORTANT SAFETY INFORMATION Serious side effects can happen in people who take JANUVIA, including pancreatitis, which may be severe and lead to death. Before you start taking JANUVIA, tell your doctor if you've ever had pancreatitis. Stop taking JANUVIA and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis. Before you start taking JANUVIA, tell your doctor if you have ever had heart failure (your heart does not pump blood well enough) or have problems with your kidneys. Contact your doctor right away if you have increasing shortness of breath or trouble breathing (especially when you lie down); swelling or fluid retention (especially in the feet, ankles, or legs); an unusually fast increase in weight; or unusual tiredness. These may be symptoms of heart failure. Do not take JANUVIA if you are allergic to any of its ingredients, including sitagliptin. Symptoms of serious allergic reactions to JANUVIA, including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing, can occur. If you have any symptoms of a serious allergic reaction, stop taking JANUVIA and call your doctor right Continue reading >>