Janumet Xr (sitagliptin And Metformin Hcl): Side Effects, Interactions, Warning, Dosage & Uses
(sitagliptin and metformin HCl) Extended-Release Tablets Postmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias. The onset of metformin-associated lactic acidosis is often subtle, accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, somnolence, and abdominal pain. Metformin-associated lactic acidosis was characterized by elevated blood lactate levels (>5 mmol/Liter), anion gap acidosis (without evidence of ketonuria or ketonemia), an increased lactate/pyruvate ratio, and metformin plasma levels generally >5 mcg/mL [see Use In Specific Populations ]. Risk factors for metformin-associated lactic acidosis include renal impairment, concomitant use of certain drugs (e.g., carbonic anhydrase inhibitors such as topiramate), age 65 years old or greater, having a radiological study with contrast, surgery and other procedures, hypoxic states (e.g., acute congestive heart failure), excessive alcohol intake, and hepatic impairment. Steps to reduce the risk of and manage metformin-associated lactic acidosis in these high risk groups are provided in the full prescribing information [see DOSAGE AND ADMINISTRATION , CONTRAINDICATIONS , WARNINGS AND PRECAUTIONS , DRUG INTERACTIONS , and Use In Specific Populations ]. If metformin-associated lactic acidosis is suspected, immediately discontinue JANUMET XR and institute general supportive measures in a hospital setting. Prompt hemodialysis is recommended [see Use In Specific Populations ]. JANUMET XR tablets contain two oral antidiabetic medications used in the management of type 2 diabetes : sitagliptin and metformin hydrochloride extended-release. Sitagliptin is an orally-active inhibitor of the dipeptidyl peptidas Continue reading >>
Metformin And Sitagliptin (janumet)
are allergic to dapagliflozin or any of the ingredients in FARXIGA. Symptoms of a serious allergic reaction may include skin rash, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. If you have any of these symptoms, stop taking FARXIGA and contact your healthcare provider or go to the nearest hospital emergency room right away have severe kidney problems or are on dialysis. Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with FARXIGA Dehydration (the loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at a higher risk of dehydration if you have low blood pressure; take medicines to lower your blood pressure, including water pills (diuretics); are 65 years of age or older; are on a low salt diet, or have kidney problems Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with FARXIGA. Ketoacidosis is a serious condition which may require hospitalization and may lead to death. Symptoms may include nausea, tiredness, vomiting, trouble breathing, and abdominal pain. If you get any of these symptoms, stop taking FARXIGA and call your healthcare provider right away. If possible, check for ketones in your urine or blood, even if your blood sugar is less than 250 mg/dL Kidney problems. Sudden kidney injury occurred in people taking FARXIGA. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or excessive heat exposure Serious urinary tract infections (UTI), some that lead to hospitalization, occu Continue reading >>
Januvia And Janumet
Januvia (sitagliptin) is an oral Type 2 diabetes medication manufactured by Merck & Co. The U.S. Food and Drug Administration (FDA) approved the drug in 2006, and it is one of the most popular Type 2 diabetes drugs on the market. In 2007, the FDA approved a variation of Januvia called Janumet, which is a combination of sitagliptin and metformin. Janumet also comes in an extended-release formula called Janumet XR. Januvia and Janumet are known as dipeptidyl peptidase 4 (DPP-4) inhibitors that work by helping the body produce more insulin. Both Januvia and Janumet belong to a class of drugs called dipeptidyl peptidase 4 (DPP-4) inhibitors that work by helping the body produce more insulin. Januvia was the first DPP-4 approved by the FDA and is the top-selling brand in its class. Two million prescriptions were written for Januvia in 2011. Januvia brought in about $6 billion in 2014. Merck stands to benefit from the patent on the drug until 2022. In clinical trials, Januvia proved effective in controlling blood-sugar levels. However, some studies reported rare and serious side effects, including acute pancreatitis, severe joint pain, pancreatic cancer and thyroid cancer. How Do Januvia and Janumet Work? Januvia is designed to work with other Type 2 diabetes medications, like Byetta, to increase their effectiveness. It helps lower blood sugar in two ways. It helps the body increase insulin to stabilize blood sugar and decrease sugars that are made in the liver. It is a part of the class of diabetes medications called DPP-4 inhibitors. DPP-4 is a protein made by the body that plays a role in glucose metabolism. The process works like this: After a person eats and blood sugar rises, intestinal cells release hormones called incretin hormones. Incretin stimulates pancreatic cell Continue reading >>
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Prescription Discounts Up To 75% Off
Living with Type 2 Diabetes can be a challenge, but a balance of diet and exercise and the right prescription medication can make life much easier. Januvia and Janumet are two oral medications that can help lower blood sugar in adults with Type 2 Diabetes. Lowering blood sugar in this condition can save you from health problems in the future including kidney and heart issues. Januvia vs. Janumet The main acting ingredient in Januvia is Sitagliptin. Sitagliptin increases the production of GLP-1 and GIP hormones in your body. These hormones are responsible for helping to lower blood sugar and stimulating insulin production in your pancreas. This insulin is essential to keeping your blood sugar from getting too high or too low. Janumet is actually made up of two drugs, Sitagliptin and Metformin. Like in Januvia, the sitagliptin produces insulin, while the addition of Metformin helps to control the amount of glucose in your blood. Metformin lowers the amount of glucose you take in from your food and increases your body’s response to insulin. Some patients may already be taking Metformin on its own, but the addition of the Sitagliptin helps to lower blood sugar even more. If you are unable to take Metformin, Januvia can be a great and safer option. A balanced diet and regular exercise are key while taking both of these medications. Consult your doctor to develop a diet and exercise plan that will be easy to maintain long term. Neither medication should be used as a substitute for a healthy diet and consistent exercise. Side Effects Serious side effects may occur, which is why it is essential to talk to a doctor before taking either medication. Be sure to alert your doctor of previous medical conditions, especially pancreatitis, kidney problems, and liver problems. If you d Continue reading >>
Januvia And Janumet | Pancreatitis And Pancreatic Cancer Diabetes Drug
The Food and Drug Administration has warned that the diabetes drugs Januvia and Janumet may increase the risk of pancreatic cancer and pancreatitis. The agency launched a safety review of two drugs and similar diabetes medications after researchers found that they could increase a patients risk of pancreatic symptoms that could lead to cancer. Manufactured by Merck, Januvia and Janumet both contain the same active ingredient, sitagliptin. The two drugs are part of a class of type II diabetes drugs known as incretin mimics, which control levels of a glucose hormone that works with the pancreas to increase insulin levels in the blood after eating. Other incretin mimics include Byetta and Bydureon, which are manufactured by Bristol-Myers Squibb. Januvia, Janumet Linked to Risk ofPancreatic Injury Concerns about the safety of Januvia and Janumet arose in February 2013 after a study was published by the journal JAMA Internal Medicine. The study revealed that patients taking Januvia and Janumet or similar medications were twice as likely to develop acute pancreatitis. Although the FDA had linked these drugs to a risk of pancreatitis and inflammation of the pancreas as early as 2007, the JAMA study shed new light on the potential danger posed by these drugs. Other studies have found that patients taking Januvia and Janumet may be up to six times more likely to develop pancreatitis. Some patients have also developed cancer of the pancreas after taking Januvia or Janumet. The FDA has also warned about high levels of pre-cancerous cells known as pancreatic duct metaplasia in patients taking diabetes drugs such as Januvia and Janumet. The agencys safety review will collect additional data in order to determine the risk of pancreatic cancer associated with the use of Januvia, Janu Continue reading >>
Sitagliptin And Metformin (oral Route)
Proper Use Drug information provided by: Micromedex Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to. This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions. Metformin and sitagliptin combination should be taken with meals to help reduce any stomach upset. Take the extended-release tablets as directed in the evening. Swallow the extended-release tablet or immediate-release tablet whole. Do not crush, break, or chew it. Carefully follow the special meal plan your doctor gave you. This is the most important part of controlling your diabetes, and is necessary if the medicine is to work properly. Exercise regularly and test for sugar in your blood or urine as directed. While taking Janumet® XR, you may see tablets in your stools. If you see tablets in your stool several times, tell your doctor right away. Do not stop taking this medicine without checking first with your doctor. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For type 2 diabetes: For oral dosage form (extended-release tablets): Fo Continue reading >>
The Difference Between
JANUMET tablets contain 2 prescription medicines: sitagliptin (JANUVIA®) and metformin. Once-daily prescription JANUMET XR tablets contain sitagliptin (the medicine in JANUVIA®) and extended-release metformin. JANUMET or JANUMET XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. JANUMET or JANUMET XR should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUMET or JANUMET XR. Metformin, one of the medicines in JANUMET and JANUMET XR, can cause a rare but serious side effect called lactic acidosis (a buildup of lactic acid in the blood), which can cause death. Lactic acidosis is a medical emergency that must be treated in a hospital. Call your doctor right away if you get any of the following symptoms, which could be signs of lactic acidosis: feel cold in your hands or feet; feel dizzy or lightheaded; have a slow or irregular heartbeat; feel very weak or tired; have unusual (not normal) muscle pain; have trouble breathing; feel sleepy or drowsy; have stomach pains, nausea, or vomiting. Most people who have had lactic acidosis with metformin have other things that, combined with the metformin, led to the lactic acidosis. Tell your doctor if you have any of the following, because you have a higher chance of getting lactic acidosis with JANUMET or JANUMET XR if you: have severe kidney problems or your kidneys are affected by certain x-ray tests that use injectable dye; have liver problems; drink alcohol very often, or drink a lot of alcohol in short-term “binge” drinking; get dehydrated (lose large amounts of body fluids, w Continue reading >>
And Weight Gain
JANUMET tablets contain 2 prescription medicines: sitagliptin (JANUVIA®) and metformin. Once-daily prescription JANUMET XR tablets contain sitagliptin (the medicine in JANUVIA®) and extended-release metformin. JANUMET or JANUMET XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. JANUMET or JANUMET XR should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUMET or JANUMET XR. Metformin, one of the medicines in JANUMET and JANUMET XR, can cause a rare but serious side effect called lactic acidosis (a buildup of lactic acid in the blood), which can cause death. Lactic acidosis is a medical emergency that must be treated in a hospital. Call your doctor right away if you get any of the following symptoms, which could be signs of lactic acidosis: feel cold in your hands or feet; feel dizzy or lightheaded; have a slow or irregular heartbeat; feel very weak or tired; have unusual (not normal) muscle pain; have trouble breathing; feel sleepy or drowsy; have stomach pains, nausea, or vomiting. Most people who have had lactic acidosis with metformin have other things that, combined with the metformin, led to the lactic acidosis. Tell your doctor if you have any of the following, because you have a higher chance of getting lactic acidosis with JANUMET or JANUMET XR if you: have severe kidney problems or your kidneys are affected by certain x-ray tests that use injectable dye; have liver problems; drink alcohol very often, or drink a lot of alcohol in short-term “binge” drinking; get dehydrated (lose large amounts of body fluids, w Continue reading >>
Januvia, Janumet To Note Pancreatitis Cases
Januvia, Janumet to Note Pancreatitis Cases FDA Wants Reports of Acute Pancreatitis in Prescribing Information for Diabetes Drugs Januvia and Janumet Sept. 25, 2009 -- The FDA wants the maker of the type 2 diabetes drugs Januvia and Janumet to change the prescribing information to note reports of acute pancreatitis , a potentially life-threatening pancreas problem. The FDA today announced that it has gotten reports of 88 people taking those drugs who developed acute pancreatitis between Oct. 16, 2006, and Feb. 9, 2009. Those cases include two cases of hemorrhagic pancreatitis (inflammation of the pancreas with bleeding) or necrotizing pancreatitis (in which the inflamed pancreas destroys itself). Januvia and Janumet both include the active ingredient sitagliptin ; Janumet also includes another drug, metformin . Today's FDA announcement focuses only on sitagliptin. The FDA has this advice for patients taking Januvia or Janumet: Be aware that acute pancreatitis has been reported in patients using Januvia or Janumet. Pay close attention for any signs or symptoms of pancreatitis, such as nausea , vomiting , not eating, and persistent severe abdominal pain , which may radiate to the back. Promptly discuss any signs and symptoms of pancreatitis with a health care professional. Do not stop or change medicines that have been prescribed without first talking with a knowledgeable health care professional. The FDA has asked Merck, the drug company that makes Januvia and Janumet, to make the following changes to the drugs' prescribing information: Note the reports of acute pancreatitis, including the severe forms of hemorrhagic or necrotizing pancreatitis Recommend that health care professionals monitor patients carefully for signs of pancreatitis when starting patients on either Continue reading >>
(sitagliptin And Metformin Hcl) Tablets Or
JANUMET tablets contain 2 prescription medicines: sitagliptin (JANUVIA®) and metformin. Once-daily prescription JANUMET XR tablets contain sitagliptin (the medicine in JANUVIA®) and extended-release metformin. JANUMET or JANUMET XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. JANUMET or JANUMET XR should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUMET or JANUMET XR. Selected Risk Information About JANUMET and JANUMET XR Metformin, one of the medicines in JANUMET and JANUMET XR, can cause a rare but serious side effect called lactic acidosis (a buildup of lactic acid in the blood), which can cause death. Lactic acidosis is a medical emergency that must be treated in a hospital. Call your doctor right away if you get any of the following symptoms, which could be signs of lactic acidosis: feel cold in your hands or feet; feel dizzy or lightheaded; have a slow or irregular heartbeat; feel very weak or tired; have unusual (not normal) muscle pain; have trouble breathing; feel sleepy or drowsy; have stomach pains, nausea, or vomiting. Most people who have had lactic acidosis with metformin have other things that, combined with the metformin, led to the lactic acidosis. Tell your doctor if you have any of the following, because you have a higher chance of getting lactic acidosis with JANUMET or JANUMET XR if you: have severe kidney problems or your kidneys are affected by certain x-ray tests that use injectable dye; have liver problems; drink alcohol very often, or drink a lot of alcohol in short-term “binge” drinkin Continue reading >>
Compare Janumet Vs Januvia - Iodine.com
Head-to-head comparisons of medication uses, side effects, ratings, and more. Janumet is a combination of two anti-diabetic medicines that work better together, but is available as brand only. 3.4/ 5 average rating with 79 reviewsforJanumet Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine. 3.2/ 5 average rating with 143 reviewsforJanuvia This 2-in-1 combination can lower the number of pills you have to take daily. Lowers A1c (average blood sugar over time) up to 2.5%. Available in extended and immediate release forms to allow better control of your blood sugar. Doesn't increase your appetite unlike other anti-diabetic medicines. Does not cause hypoglycemia or very low blood sugar. Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class. Uses the hormones naturally produced by your body to affect how sugar is processed. It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines. Available as brand name only and may be expensive. Metformin component usually causes upset stomach. Sitagliptin component may increase your risk for throat infections and inflammation of pancreas. Not appropriate for those with poor kidney function. Lowers A1c (average blood sugar over time) by less than 1%. Some people might get frequent cold-like symptoms. Rare but serious side effects include pancreatitis and severe joint pain. Continue reading >>
Fda Adds Heart Failure Warning To Januvia And Janumet
Despite neutral heart outcome study results, the FDA added a warning for those at risk of heart failure Januvia, a once-daily pill for type 2 diabetes (a DPP-4 inhibitor), has a new warning label for increased risk of heart failure. Though a recent outcome study showed clearly that Januvia is no riskier for the heart, the FDA seems to be taking a conservative approach based on other studies of similar drugs. The heart outcomes trial in question was called TECOS, which compared people taking Januvia, Janumet, or Janumet XR (sitagliptin) to people taking placebo. The study reported a neutral finding – the drugs in the Januvia family neither increased nor decreased instances of hospitalization for heart failure. In contrast, Onglyza, another DPP-4 inhibitor with the same heart failure warning as Januvia now has, was associated with a 27% increase in heart failure hospitalizations in the SAVOR-TIMI heart outcome trial. The FDA has also included heart failure warnings for Nesina and Tradjenta, the other two FDA-approved DPP-4 inhibitors. The warning added to the Januvia label appears to be a “just-in-case” decision by the FDA, based on the studies of DPP-4 inhibitors other than Januvia. It should be noted that the FDA warning label for Januvia and Janumet (which combines Januvia and metformin) cautions against prescribing these medications for people at risk for heart failure. What that means is for people without risk for heart failure, Januvia is considered a viable treatment option. (Major risk factors for heart failure include a history of heart attack, coronary artery disease, or high blood pressure.) Januvia and other DPP-4 inhibitors are typically used early in the course of type 2 diabetes, as they bring low risk of hypoglycemia and few side effects. Whether yo Continue reading >>
What Is Janumet (metformin And Sitagliptin)?
Janumet is the brand name for a prescription drug that contains metformin and sitagliptin. It's used along with diet and exercise to lower blood sugar in people who have type 2 diabetes. If you have type 2 diabetes, your body doesn't make or use the hormone insulin normally, so it can't control the amount of sugar, or glucose, in the blood. Metformin belongs to a drug class known as biguanides. Biguanides lower blood-sugar levels in three ways: decreasing the glucose produced by your liver; slowing absorption of sugar in the digestive system; and increasing the amount of sugar that muscle cells absorb. Sitagliptin is known as a DPP-4 (dipeptidyl peptidase-4 ) inhibitor. Sitagliptin increases the amount of insulin your pancreas creates, reduces the glucose from your liver, and slows absorption of sugars in your gut. It also affects the brain, reducing the amount of food you eat by increasing your sense of fullness. Taking Janumet, along with adopting a healthy lifestyle, can decrease your risk of developing the serious or life-threatening complications of type 2 diabetes. These may include cardiovascular diseases, such as heart attack, stroke, and problems related to blood circulation; nerve damage; kidney disease; or eye conditions. Janumet is manufactured by Merck & Co. and was approved by the Food and Drug Administration (FDA) in 2007. Janumet Warnings The FDA requires a black-box warning for Janumet, because it may cause a rare but serious condition called lactic acidosis (a buildup of lactic acid in the blood). Stop taking the drug and call your doctor immediately or get emergency help if you experience any of the following side effects: Extreme weakness, fatigue, or discomfort Nausea, vomiting, or stomach pain Decreased appetite Deep and rapid breathing or shortnes Continue reading >>
The Pros And Cons Of Januvia And Janumet
Januvia (sitagliptin) doesnt usually cause weight loss or gain.(JASON REEKIE/ISTOCK/HEALTH)Januvia (sitagliptin) is a type 2 diabetes drug that was approved in 2006. It is also available in a combination pill (known as Janumet) that contains the drug metformin. They are the first drugs in a new class called the selective dipeptidyl peptidase-4 inhibitors, or DPP-4 inhibitors. Januvia has a big advantage in that it can stimulate insulin production in the body, and may be less likely to cause hypoglycemia than other drugs. If blood glucose falls too low, the drug ceases to stimulate insulin production. The disadvantage? The price. The drug is "very expensive," says Glenn Cunningham, MD, an endocrinologist and professor at Baylor College of Medicine in Houston. He notes that it costs $160 for a 30-day supply of 100-mg tablets. Nevertheless, "Januvia is becoming a much more popular drug," Dr. Cunningham says. It does not cause weight gain or weight loss, he explained, and is less likely to cause hypoglycemia. Continue reading >>
Glyburide Vs. Januvia/janumet
I have not been able to hit my target numbers on the 1500mg Metformin I was on. My A1C in October was 7.3 and this week it was 8.3. I've been seeing a general physician for my management and she recommened upping the Metformin to 2000mg and adding 5mg of Glyburide once a day. I went and saw an Endo. and he recommened upping the Metformin to 2000mg as well but wanted to add 100mg of Januvia until I finished up my current supply of Metformin at which time I'd switch to Janumet 50/1000mg twice per day. I started takinig Glyburide for the first time this morning after breakfast along with my Metformin. Three hours later I was going hypo. with a bgl of 65. I had lunch and a little OJ and i"m up in the mid to high 90's. Which is great because ever since my DX I have not been able to get below 140 bgl. I am worried that Glyburide will cause me to go hypo frequently and it scares me as I have never had to deal with that. I've read that Januvia only works when your BGL is high and does not induce hypos. Ok, so here's the conundrum: A 30 day supply of Glyburide costs be $1.62. A thirty day supply of Januvia or Janumet will cost me A little over $50. I filled my scripts yesterday for a thirtyday supply each of Metformin, Glyburide and an ACE inhibitor (don't recall name-switching from Altace) all for $4.62 What to do? Continue on the Glyburide to see how it works out for me? Or just switch to Januvia? Obviously Januvia's expense makes it less appealing. So...you get all 3 Rx for just $4.62? WOW! cool deal... I take Januvia and from what I understand it is suppose to help your pancreas make more insulin to help lower the BG and signals your liver to make less sugar. I take my dose at bedtime to help my BG in the morning...but an increase of $45/mo for meds is kind of a big jump in Continue reading >>
