Is Invokana The Same As Metformin?

Oral Diabetes Medications

A list of oral diabetes medications with advantages, disadvantages, and side effects. Click on the name of a drug for more information. Biguanides Glucophage (generic name: metformin) Glucophage XR (generic name: metformin hydrochloride) extended release Fortamet (generic name: metformin hydrochloride) extended release Glumetza (generic name: metformin hydrochloride) extended release Riomet (generic name: metformin hydrochloride liquid) What are Biguanides? Metformin is the only member of the biguanides family in use today. Metformin (met-FOR-min) helps lower blood glucose by making sure your liver does not put extra glucose into the system when it is not needed. The ADA Standards of Medical Care in Diabetes recommend the inclusion of metformin (along with diet and exercise) in initial diabetes treatment. A good thing about metformin is that it does not cause blood glucose to get too low (hypoglycemia) when it is the only diabetes medicine you take. Who can take this medicine? Adults with type 2 diabetes can take metformin with their doctor’s approval and supervision. You should avoid metformin if you have liver or kidney problems, lung or heart disease, or conditions that cause low blood oxygen levels. Who should not take this medicine? People with certain types of heart problems, such as congestive heart failure, should use caution with this medicine. People with reduced kidney function or kidney disease should probably not take metformin. It should be used with caution if you regularly consume more than two to three drinks daily, so check with your doctor about that. Advantages Metformin, when used alone, is unlikely to cause low blood sugar. It is one of those medicines that always seems to help even after people have had diabetes for a while, and, for this reason Continue reading >>

Combination Metformin, Invokana Reduces Hba1c, Body Weight

Combination metformin, Invokana reduces HbA1c, body weight Rosenstock J, et al. Diabetes Care. 2016;doi:10.2337/dc15-1736. In drug-naive patients with type 2 diabetes, a combination of Invokana and metformin was more effective than monotherapy with either drug, according to recent findings. Researchers also found Invokana (canagliflozin, Janssen) monotherapy noninferior to metformin monotherapy. Julio Rosenstock, MD, director of the Dallas Diabetes and Endocrine Center at Medical City, and colleagues evaluated data from a phase 3 study conducted at 158 centers in 12 countries from May 2013 to December 2014 on 1,186 drug-naive patients (mean age, 54.9 years) with type 2 diabetes (mean duration, 3.3 years) to determine the safety and efficacy of therapy with the sodium-glucose cotransporter 2 inhibitor canagliflozin combined with metformin or monotherapy with each drug. Participants were randomly assigned 100 mg canagliflozin plus metformin (n = 237), 300 mg canagliflozin plus metformin (n = 237), 100 mg canagliflozin (n = 237), 300 mg canagliflozin (n = 238) or metformin (n = 237). Greater reductions in HbA1c were found with the combination therapies compared with metformin alone and canagliflozin alone (P = .001 for all). At week 26, compared with metformin alone, more participants had HbA1c less than 7% in the canagliflozin 100 mg plus metformin group (P = .027) and the canagliflozin 300 mg plus metformin group (P = .016). Compared with metformin alone, significant reductions in body weight were found in the combination therapy groups (P = .001 for both). Serious adverse events were low across all groups ( 3%). [Canagliflozin 100 mg] and [canagliflozin 300 mg] in combination with [metformin] provided significantly greater reductions in HbA1c and body weight compared w Continue reading >>

Important Safety Information

INVOKAMET®/INVOKAMET® XR can cause serious side effects, including: Amputations. INVOKAMET®/INVOKAMET® XR may increase your risk of lower-limb amputations. Amputations mainly involve removal of the toe or part of the foot; however, amputations involving the leg, below and above the knee, have also occurred. Some people had more than one amputation, some on both sides of the body. You may be at a higher risk of lower-limb amputation if you: have a history of amputation, have heart disease or are at risk for heart disease, have had blocked or narrowed blood vessels (usually in leg), have damage to the nerves (neuropathy) in the leg, or have had diabetic foot ulcers or sores. Call your doctor right away if you have new pain or tenderness, any sores, ulcers, or infections in your leg or foot. Your doctor may decide to stop your INVOKAMET®/INVOKAMET® XR for a while if you have any of these signs or symptoms. Talk to your doctor about proper foot care. Lactic Acidosis. Metformin, one of the medicines in INVOKAMET®/INVOKAMET® XR, can cause a rare but serious condition called lactic acidosis (a build-up of lactic acid in the blood) that can cause death. Lactic acidosis is a medical emergency and must be treated in the hospital. Call your doctor right away if you have any of the following symptoms, which could be signs of lactic acidosis: feel cold in your hands or feet; feel very weak or tired; have unusual (not normal) muscle pain; have trouble breathing; have unusual sleepiness or sleep longer than usual; have stomach pains, nausea, or vomiting; feel dizzy or lightheaded; or have a slow/irregular heartbeat You have a higher chance of getting lactic acidosis with INVOKAMET®/INVOKAMET® XR if you have conditions such as: severe kidney problems, or your kidneys are affe Continue reading >>

Invokana And Metformin Combination Beneficial For Type 2 Diabetes Patients, Study Suggests

Invokana and metformin combination beneficial for type 2 diabetes patients, study suggests Invokana and metformin combination beneficial for type 2 diabetes patients, study suggests Adding Januvia to insulin-treated type 2 diabetes patients could have cardiovascular benefits 01 February 2016 A combination therapy of metformin and Invokana is more effective in treating drug-nave type 2 diabetes patients compared to single therapy with either drug, according to new research. Researchers at the Dallas Diabetes and Endocrine Centre at Medical City, United States aimed to investigate if Invokana (the trade name of canagliflozin) , an SGLT2 inhibitor, could effectively and safely be used alongside metformin in type 2 diabetes patients not taking medication. They evaluated data from a phase III study conducted at 158 health centres in 12 countries between May 2013 and December 2014. 1,186 drug-nave patients were monitored; of whom the mean age was 54.9 years and mean type 2 diabetes duration was 3.3 years. Across 26 weeks, patients were randomised to 100mg canagliflozin plus metformin , 300mg canagliflozin plus metformin, 100mg canagliflozin, 300mg canagliflozin or metformin. The primary aim of the researchers was to assess changes in HbA1c , but changes in fasting plasma glucose and body weight were also observed. Greater reductions from baseline HbA1c were found in the combination therapy groups compared to monotherapy with either metformin or canagliflozin. Those taking combination therapy also had more significant reductions in body weight. Serious adverse events were low across all groups. "Initial therapy with CANA plus MET was more effective and generally well tolerated versus each monotherapy in drug-nave type 2 diabetes," the researchers concluded. The findings were Continue reading >>

Invokana Compared To Metformin And Januvia

Every year, the American Diabetes Association updates its “standards of medical care in diabetes.” The 2016 edition, which is 119 pages long, is available here. The most important part for type 2 diabetics is found on page 61, which has a chart showing the therapies used to treat diabetes. First step is always metformin. Metformin is highly effective and low-risk, with side effects that are uncomfortable but typically not dangerous, like stomach pain, nausea, vomiting, or diarrhea. (Some patients, however, develop lactic acidosis.) When another drug is added to metformin (called “dual therapy”), there are a variety of options, including insulin, sulfonylureas, thiazolidinediones, DPP-4 inhibitors, GLP-1 receptor agonists, and SGLT-2 inhibitors. Invokana is a SGLT-2 inhibitor. Januvia is a DPP-4 inhibitor. SGLT-2 inhibitors like Invokana treat diabetes by acting on the kidneys, where they block the reabsorption of glucose, leading to less glucose in the blood. DPP-4 inhibitors treat diabetes by acting on the pancreas, where they help maintain higher levels of GLP-1, a hormone which triggers the production of insulin by the pancreas. As the American Diabetes Association says, “Drug choice is based on patient preferences, as well as various patient, disease, and drug characteristics, with the goal of reducing blood glucose levels while minimizing side effects, especially hypoglycemia.” Obviously, you should discuss all of these issues with your doctor, and carefully consider their advice. But when it comes to the “patient preferences,” what should you know? As the Invokana website points out, there was indeed a clinical trial where Invokana was shown to be modestly better than Januvia in reducing A1C levels. Similarly, a “retrospective matched-control coh Continue reading >>

Official Hcp Website Of Invokana (canagliflozin)

An increased risk of lower-limb amputations associated with INVOKANA use versus placebo was observed in CANVAS (5.9 vs 2.8 events per 1000 patient-years) and CANVAS-R (7.5 vs 4.2 events per 1000 patient-years), two large, randomized, placebo-controlled trials in patients with type 2 diabetes who had established cardiovascular disease (CVD) or were at risk for CVD. Amputations of the toe and midfoot were most frequent; however, amputations involving the leg were also observed. Some patients had multiple amputations, some involving both limbs. Before initiating, consider factors that may increase the risk of amputation, such as a history of prior amputation, peripheral vascular disease, neuropathy, and diabetic foot ulcers. Monitor patients receiving INVOKANA for infection, new pain or tenderness, sores, or ulcers involving the lower limbs, and discontinue if these complications occur. Serious hypersensitivity reaction to INVOKANA Patients with severe renal impairment (eGFR <30 mL/min/1.73 m2) who are being treated for glycemic control Lower-Limb Amputation: An increased risk of lower-limb amputations associated with INVOKANA use versus placebo was observed in CANVAS (5.9 vs 2.8 events per 1000 patient-years) and CANVAS-R (7.5 vs 4.2 events per 1000 patient-years), two randomized, placebo-controlled trials evaluating patients with type 2 diabetes who had either established cardiovascular disease or were at risk for cardiovascular disease. The risk of lower-limb amputations was observed at both the 100-mg and 300-mg once-daily dosage regimens. Amputations of the toe and midfoot (99 out of 140 patients with amputations receiving INVOKANA in the two trials) were the most frequent; however, amputations involving the leg, below and above the knee, were also observed (41 out o Continue reading >>

Canagliflozin, Invokana

Is canagliflozin safe to take if I'm pregnant or breastfeeding? What is canagliflozin, and how does it work (mechanism of action)? Canagliflozin is an oral drug that reduces blood sugar (glucose) levels in patients with type 2 diabetes. It is a new type of diabetes medication in a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors. Under normal conditions, glucose is filtered out of the blood and into the kidney tubules as blood passes through the kidneys. The glucose then as absorbed from the tubules back into the blood so that glucose is not lost in the urine. SGLT2 is an enzyme in the kidney tubule that causes glucose to be reabsorbed from urine. Canagliflozin blocks the action of SGLT2. Therefore, canagliflozin reduces the reabsorption of glucose from renal tubules, leading to more excretion of glucose in urine. Canagliflozin was approved by the FDA in March 2013. What are the side effects of canagliflozin? AND PRECAUTIONSThe most common side effects of canagliflozin are: Other side effects of canagliflozin include: Diabetes Diet: Healthy Meal Plans for Diabetes-Friendly Eating What is the dosage for canagliflozin? Canagliflozin should be taken before the first meal of the day. The recommended starting dose is 100 mg once daily and the maximum dose is 300 mg once daily. Renal function should be assessed prior to starting canagliflozin and periodically during treatment, and the dose of canagliflozin should be modified based on renal function. Which drugs or supplements interact with canagliflozin? : Canagliflozin may slightly increase the concentration of digoxin (Lanoxin) in the body when both drugs are being taken. Digoxin concentrations should be monitored appropriately. Rifampin, phenytoin (Dilantin, Dilantin-125, phenobarbital, and ri Continue reading >>

Compare Invokana Vs Metformin - Comprehensive Analysis By Treato

Depression Hair Loss Anxiety Itching Cough Treato does not review third-party posts for accuracy of any kind, including for medical diagnosis or treatments, or events in general. Treato does not provide medical advice, diagnosis or treatment. Usage of the website does not substitute professional medical advice. The side effects featured here are based on those most frequently appearing in user posts on the Internet. The manufacturer's product labeling should always be consulted for a list of side effects most frequently appearing in patients during clinical studies. Talk to your doctor about which medications may be most appropriate for you. The information reflected here is dependent upon the correct functioning of our algorithm. From time-to-time, our system might experience bugs or glitches that affect the accuracy or correct application of mathematical algorithms. We will do our best to update the site if we are made aware of any malfunctioning or misapplication of these algorithms. We cannot guarantee results and occasional interruptions in updating may occur. Please continue to check the site for updated information. Continue reading >>

Invokana Superior As Second Add-on To Metformin

Home / Therapies / SGLT-2 Therapy Center / Invokana Superior As Second Add-on to Metformin Invokana Superior As Second Add-on to Metformin New study indicates canagliflozin superior to glimepiride in lowering A1C. Over a one-year study, glycemic control was improved and body weight and blood pressure were reduced with Invokana (canagliflozin, Janssen) as add-on therapy to metformin in patients with type 2 diabetes, according to a presentation at AACE. Assessment of noninferiority of Invokana to glimepiride was based on a pre-specified noninferiority margin of 0.3%. If noninferiority was shown, the protocol specified a step-down assessment of superiority on the basis of an upper bound of the 95% CI for the difference of each Invokana dose vs glimepiride of less than 0.0%. Mean daily dose=5.6 mg. Glimepiride titration up to 6 mg or 8 mg was allowed throughout the study. Invokana 100 mg difference from glimepiride: 0.01% (95% CI: 0.11, 0.09) Invokana 300 mg difference from glimepiride: 0.12% (95% CI: 0.22, 0.02) Secondary endpoint at 52 weeks: Percent of patients who achieved the A1C goal of <7.0% vs glimepiride:. In the randomized, double blind study, researchers from Janssen Scientific Affairs evaluated data from 1,450 adults (mean age, 56.2 years) with type 2 diabetes (mean HbA1c, 7.8%; mean BMI, 31 kg/m2) on background metformin randomly assigned to Invokana (100 mg or 300 mg) or glimepiride for 52 weeks to determine the effects of the treatments on metabolic syndrome components. Participants were further diagnosed with metabolic syndrome if they met two or more of the following criteria: triglyceride levels of at least 150 mg/dL; HDL cholesterol less than 40 mg/dL for men and less than 50 mg/dL for women; waist circumference at least 102 cm for non-Asian men, at leas Continue reading >>

Invokana Vs Metformin Comparison - Drugs.com

For Diabetes, Type 2 Although this medication did bring my sugars down a bit and my tastings incredible I had to stop taking it because of constant yeast infections. I thought I could toughen it out but after being on it for three months and no sign of the infections going away my doctor took me off of it. I have also notice my hair is so much thinner and falling out. My nails were also brittle and breaking. And make sure you drink plenty of water because it dehydrates you very fast For Diabetes, Type 2 Started taking 100 mg daily at night numbers came down in a week...went to see the Doctor in a month he was happy then he prescribed 300 mg daily...soon after taking this dosage I began to experience an itching on my penis and it was driving me crazy, also experienced more frequent urination along with an insatiable thirst. I was about to schedule an appointment with my urologist until I Googled "Side effects of Invokana". The itching wouldn't stop didn't know that there were these side effects from this medication and even though it helped bring down my sugar levels I really don't think its worth the other problems it presents. I too have experienced a weight loss. It is a good medicine but the side effects aren't worth it. Sorry For Polycystic Ovary Syndrome I got my first period when I was 11 and was regular up until I was 14 and then they stopped. Fast forward to 2015 and I hadn't had a period at all for 5 years. I decided to finally do something about it, I was actually enjoying the lack of periods to be honest! I had some tests done and the diagnosis of PCOS was confirmed. My doctor put me on metformin 500mg twice a day and I hated it. I was so nauseous for the first two weeks, frequent diarrhea and lots of dizziness but it all passed. After that I began to have m Continue reading >>

What’s Invokana? 10 Things You Need To Know

Invokana (canagliflozin) is one of the new oral medications for adult onset diabetes. It’s expensive but has many upsides. Taken usually in combination with metformin it is a rising star in the treatment of diabetes. Here is what you need to know to help you decide: worth it or not? Invokana is taken as a 100 mg tablet once daily before breakfast, increasing to a 300 mg tablet once a day if you have normal kidney function. Invokana can be taken with or without food. Invokana is not yet recommended for use alone in the treatment of diabetes; it should be given as a second agent in addition to metformin or as a third-line treatment. Invokana works on the kidneys and tells the proximal tubule to resorb approximately 90 percent of the filtered glucose load. So, Invokana promotes dumping of glucose from the kidneys to the urine. Invokana used alone doesn’t lower blood sugars (measured by the A1C blood test) enough to make it effective as a single agent for diabetes. In studies it lowers A1C by 0.5 to 0.7 percentage points, making it a relatively weak glucose lowering agent. When should Invokana be added? It has been shown to be effective in lowering A1C when metformin alone is not achieving the goal A1C of < 7.0. Invokana 300 mg compared to Januvia 100 mg mixed with metformin was better at lowering blood sugar and helped with weight loss. Will I lose weight on Invokana? Yes, in most studies Invokana (used with metformin) resulted in a 6.5 pound weight loss at 12 weeks and an almost 10 pound weight loss at the end of a year. That’s quite a plus. The huge downside of Invokana is the frequency of genital fungal infections, which are almost sixfold higher. This means there is an increased risk of genital yeast infections: vulvovaginal candidiasis (vaginal yeast infections) Continue reading >>

Invokana Side Effects Center

Invokana (canagliflozin) is a sodium-glucose co-transporter 2 (SGLT2) inhibitor used to control blood sugar in people with type 2 diabetes mellitus, in addition to diet and exercise. Common side effects of Invokana include: urinary tract infections, increased urination, yeast infections, vaginal itching, thirst, constipation, nausea, fatigue, weakness, skin sensitivity to sunlight, hypersensitivity reactions (including skin redness, rash, itching, hives, and swelling), bone fractures, and kidney problems. The recommended starting dose of Invokana is 100 mg once daily, taken before the first meal of the day. Doses may be increased to 300 mg in patients who are able to tolerate Invokana at 100 mg doses. Invokana may interact with rifampin or digoxin. Tell your doctor all medications you use. Invokana should only be given to a pregnant woman if the benefit of the drug justifies the risk of harm to the fetus. Breastfeeding women should decide with their doctors whether to breastfeed or to discontinue taking Invokana. Our Invokana (canagliflozin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Continue reading >>

Similarities And Differences Between Invokana And Metformin

Similarities And Differences Between Invokana And Metformin Similarities and Differences between Invokana and Metformin Similarities and Differences between Invokana and Metformin Pharmaceutical companies spend billions of dollars to develop drug for diseases that they can find treatments. Thousands of drugs go through the Federal food and Drug Administration (FDA) drug approval system in order to make it to human. Once they have passed trial phases, they will make it to market. FDA approved a new diabetic's drug in March 2013. The name of the drug is Invokana, chemically known as canagliflozin, and it is usually prescribed as a supplement to an exercise-and-diet routine, for improving the control of glucose in diabetes type 2 adult patients (Drugs@FDA, 2013). Approval has not been gained for the treatment of diabetes type 1 and diabetic ketoacidosis. This drug works in a new way, by causing blood sugar to be excreted in the urine. Invokana which is developed by Johnson & Johnson will have a wholesale price of $8.77 per tablet (Pollack, 2013). Many other drugs that can treat type 2 diabetic mellitus work through different mechanism, by affecting supply or use of insulin. One of these drugs is Metformin which is in a class of Biguanide and has a greatest data in treating the disease as mono-therapy or in combination with other drugs. Reductions have been noticed in blood glucose and a1c levels from the effective use of Metformin. Since both medications treat type 2 diabetic mellitus, they have similarities as well as differences. Some of the similarities between Invokana and Metformin are that they both have the same indication, treat type 2 Diabetic mellitus, reduce A1c and blood glucose levels, and decrease weight which is observed as one of their side effects. 100 mg Continue reading >>

New Metformin Combo Drug Approved For Type 2 Diabetes

On August 8, the U.S. Food and Drug Administration approved the oral combination medicine canagliflozin/metformin (brand name Invokamet) for Type 2 diabetes. Invokamet, manufactured by Johnson & Johnson subsidiary Janssen Pharmaceuticals, combines the SGLT2 inhibitor canagliflozin with the commonly prescribed diabetes drug metformin. Invokamet is the first medicine to combine an SGLT2 inhibitor and metformin available in the United States. In the process of filtering the blood, the kidneys typically reabsorb all the filtered glucose and return it to the bloodstream. One of the main proteins responsible for this reabsorption is SGLT2. By inhibiting the action of SGLT2, canagliflozin blocks the reabsorption of glucose by the kidneys, promoting a loss of glucose in the urine and lowering blood glucose levels. Metformin works by decreasing glucose production by the liver, as well as improving insulin sensitivity in the liver, muscle, and fat cells. Invokamet tablets are approved for use in conjunction with diet and exercise in adults with Type 2 diabetes whose condition is not sufficiently controlled with either canagliflozin or metformin alone or who are already taking both medicines. Studies of Invokamet indicated that taking the medicine was equivalent to taking corresponding doses of canagliflozin and metformin as individual tablets. Invokamet comes in tablet strengths containing 50 milligrams or 150 milligrams of canagliflozin and 500 milligrams or 1,000 milligrams of metformin, to be taken twice daily. This medicine should not be used to treat Type 1 diabetes or diabetic ketoacidosis (a potentially life-threatening condition marked by a chemical imbalance in the body). The most common side effects of canagliflozin are female genital fungal infections, urinary tract in Continue reading >>

What You Need To Know About Invokana And Metformin Combination

What You Need To Know About Invokana and Metformin Combination What You Need To Know About Invokana and Metformin Combination Patients with type 2 diabetes usually take metformin as the first line of treatment. Metformin is an oral prescription drug that is used with a proper diet and exercise program to control blood glucose levels in type 2 diabetic patients. If metformin does not work in controlling blood sugar levels, your health-care provider may prescribe other diabetes drugs , such as Invokana. Invokana, which is also referred to as canagliflozin, is an oral diabetes drug that works in the body by helping the kidney excrete excess sugar from the bloodstream. This medication can be used alone or in combination with metformin. Research shows that using Invokana and metformin together is more effective compared to using the individual drugs to control blood sugar levels. There is a significant decrease in HbA1c when Invokana and metformin were used as a combined therapy rather than single therapy. Invokana belongs to a class of diabetes medication known as SGLT-2 or sodium glucose co-transporter 2 inhibitors . On the other hand, metformin is the only known diabetes drug in a class of medication called biguanides . Invokana and metformin is only available as a brand name medication called Invokamet XR and Invokamet. Invokamet XR is an extended-release diabetes tablet while Invokamet is an immediate-release diabetes tablet. Invokamet or Invokamet XR can be used alone to control blood sugar in type 2 diabetic patients or in combination with other diabetes drugs. Invokana and metformin is usually prescribed with a diet and exercise program. Whether you take Invokamet or Invokamet XR, your dosage will be based on the individual dosage of Invokana and metformin. If you a Continue reading >>