Description And Brand Names
Drug information provided by: Micromedex US Brand Name Metaglip Descriptions Glipizide and Metformin combination is used to treat high blood sugar levels that are caused by a type of diabetes mellitus or sugar diabetes called type 2 diabetes. Normally, after you eat, your pancreas releases insulin to help your body store excess sugar for later use. This process occurs during normal digestion of food. In type 2 diabetes, your body does not work properly to store the excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future. Proper diet is the first step in managing type 2 diabetes but often medicines are needed to help your body. With two actions, the combination of glipizide and metformin helps your body cope with high blood sugar. Glipizide stimulates the release of insulin from the pancreas, directing your body to store blood sugar. Metformin has three different actions: it slows the absorption of sugar in your small intestine; it also stops your liver from converting stored sugar into blood sugar; and it helps your body use your natural insulin more efficiently. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Tablet Copyright © 2018 Truven Health Analytics Inc. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Continue reading >>
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Glipizide And Metformin (metaglip Has Been Discontinued In The Us)
are allergic to dapagliflozin or any of the ingredients in FARXIGA. Symptoms of a serious allergic reaction may include skin rash, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. If you have any of these symptoms, stop taking FARXIGA and contact your healthcare provider or go to the nearest hospital emergency room right away have severe kidney problems or are on dialysis. Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with FARXIGA Dehydration (the loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at a higher risk of dehydration if you have low blood pressure; take medicines to lower your blood pressure, including water pills (diuretics); are 65 years of age or older; are on a low salt diet, or have kidney problems Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with FARXIGA. Ketoacidosis is a serious condition which may require hospitalization and may lead to death. Symptoms may include nausea, tiredness, vomiting, trouble breathing, and abdominal pain. If you get any of these symptoms, stop taking FARXIGA and call your healthcare provider right away. If possible, check for ketones in your urine or blood, even if your blood sugar is less than 250 mg/dL Kidney problems. Sudden kidney injury occurred in people taking FARXIGA. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or excessive heat exposure Serious urinary tract infections (UTI), some that lead to hospitalization, occu Continue reading >>
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Uses This diabetes medication is a combination of 2 drugs (glipizide and metformin). It is used along with a diet and exercise program to control high blood sugar in patients with type 2 diabetes. Glipizide is a sulfonylurea and works by stimulating the release of your body's natural insulin and by decreasing the amount of sugar that your liver makes. Metformin is a biguanide and works by decreasing the amount of sugar that your liver makes and that your stomach/intestines absorb. Both of these medications work by helping to restore your body's proper response to the insulin you naturally produce. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. How to use Glipizide-Metformin Read the Patient Information Leaflet available from your pharmacist before you start using this medication and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Take this medication by mouth, usually once or twice a day with meals or as directed by your doctor. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects (such as upset stomach), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. If you are already taking another diabetes drug (e.g., chlorpropamide), follow your docto Continue reading >>
What Is Glipizide / Metformin?
QUICK LINKS Oral route (Tablet) Lactic acidosis is a rare, but serious, metabolic complication that can occur due to metformin accumulation during treatment with glipiZIDE/metformin hydrochloride; when it occurs, it is fatal in approximately 50% of cases. The risk of lactic acidosis increases with renal impairment, increased age, diabetes mellitus, congestive heart failure, hepatic insufficiency, and other conditions whenever there is significant tissue hypoperfusion and hypoxemia. Treatment with glipiZIDE/metformin hydrochloride should not be initiated in patients 80 years of age or older unless measurement of creatinine clearance demonstrates that renal function is normal. Therapy should temporarily be discontinued prior to any intravascular radiocontrast study or surgical procedure. Avoid excessive alcohol use since alcohol potentiates the effects of metformin on lactate metabolism. Discontinue therapy immediately and institute supportive measures promptly for suspected lactic acidosis . Save up to 75% on Glipizide / Metformin Find big savings at pharmacies near you with GoodRx discount coupons Average Retail Price: $56.08 Lowest GoodRx Price $13.80 View All Prices Glipizide and Metformin combination is used to treat high blood sugar levels that are caused by a type of diabetes mellitus or sugar diabetes called type 2 diabetes. Normally, after you eat, your pancreas releases insulin to help your body store excess sugar for later use. This process occurs during normal digestion of food. In type 2 diabetes, your body does not work properly to store the excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future. Proper diet is the first step in managing type 2 diabetes but often medicines are needed Continue reading >>
Difference Between Glipizide And Metformin
Glipizide vs Metformin Glipizide and metformin, both these drugs are used in the treatment of type 2 diabetes. What are Glipizide and Metformin? Glipizide is an oral, rapid and short acting, anti-diabetic drug belonging to the class of medications called sulfonylureas. Glipizide lowers blood sugar by causing the pancreas to produce insulin and helping the body use this insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally but the body is not being able to utilize it well due to resistance to the insulin. Metformin is in a class of drugs called biguanides. Metformin helps to control the amount of glucose in your blood. It decreases the amount of glucose you absorb from your food and the amount of glucose made by your liver. Metformin also increases your body’s response to insulin, a natural substance that controls the glucose metabolism in the body. Difference in mode of action Glipizide is not used to treat type 1 diabetes in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood in diabetes type 1 or in cases of diabetic ketoacidosis. Glipizide is only part of a complete program of treatment that may also include diet, exercise, weight control, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely when on glipizide. Before starting glipizide, you should make sure that it’s safe for you to take it. Inform your doctor if you have kidney or liver disease, chronic diarrhea or a blockage in your intestines, glucose-6-phosphate dehydrogenase deficiency (G6PD), a disorder of your pituitary or adrenal glands, a history of heart disease, or if you are malnourished. Metformin is the first-line drug of choice for the treatm Continue reading >>
Glipizide-metformin Side Effects
Glipizide and metformin is a combination of two oral diabetes medicines that help control blood sugar levels. Glipizide and metformin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes. This medicine is not for treating type 1 diabetes. Glipizide and metformin may also be used for purposes not listed in this medication guide. You should not use glipizide and metformin if you have severe kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking glipizide and metformin. Some people taking metformin develop a serious condition called lactic acidosis. Stop taking this medicine and get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired. You should not use this medicine if you are allergic to glipizide or metformin, or if you have: severe kidney disease; or metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking glipizide and metformin. To make sure glipizide and metformin is safe for you, tell your doctor if you have: kidney disease; congestive heart failure, especially if you take digoxin (Lanoxin) or furosemide (Lasix); a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency; liver disease; heart disease; or if you are over 80 years old and have not Continue reading >>
Glipizide And Metformin
Glipizide-Metformin 2.5 mg-250 mg-MYL round, white, imprinted with G31, M What is the most important information I should know about glipizide and metformin? Do not use glipizide and metformin if you have congestive heart failure or kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking glipizide and metformin. Take care not to let your blood sugar get too low. Low blood sugar (hypoglycemia) can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency. Some people develop lactic acidosis while taking metformin. Early symptoms may get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired. What is glipizide and metformin? Glipizide and metformin is a combination of two oral diabetes medicines that help control blood sugar levels. Glipizide and metformin is for people with type 2 diabetes who do not use daily insulin injections. This medication is not for treating type 1 diabetes. Glipizide and metformin may also be used for purposes not listed in this medication guide. What should I discuss with my healthca Continue reading >>
Is There A Generic Version Of Glipizide-metformin?
Is there a generic version of glipizide-metformin? Yes, glipizide-metformin is the generic version of this oral diabetic medication and, consequently, it is the main ingredient. This medication is available either in its generic form, called glipizide-metformin, or a brand name, called Metaglip. Glipizide-metformin can be found in regular tablet form or in an extended release form. All of these medications help to lower blood sugar levels related to type 2 diabetes. The U.S. Food and Drug Administration (FDA) has approved generic glipizide-metformin that is manufactured by pharmaceutical companies like Teva Pharmaceuticals, Mylan Laboratories and Caraco. What happens if I miss a dose of Janumet? If you miss a dose of Janumet, you should take it as soon as you remember. However, if it is almost time for your next dose, ... What happens if I miss a dose of glimepiride? If you miss a dose of glimepiride, you should take it as soon as you remember. However, you should never take more than your ... What should I avoid while taking Janumet? While taking Janumet, you should avoid drinking alcohol, especially in excessive quantities. When consumed with Janumet, alco... When should I call my doctor if I am taking Precose? If you are taking Precose (acarbose), a drug for type 2 diabetes, you should call your doctor right away if you have certain ... Continue reading >>
What Is Glipizide (glucotrol)?
Glipizide is the generic form of the prescription drug Glucotrol. It's used along with diet and exercise to help control blood-sugar levels in people who have type 2 diabetes. If you have type 2 diabetes, your body doesn't make or use the hormone insulin normally, so it can't control the amount of sugar, or glucose, in the blood. Glipizide is in a class of drugs known as sulfonylureas. They cause the pancreas to produce the hormone insulin. Insulin directs your body's cells to store excess sugar, lowering the levels that circulate in your blood. Taking glipizide, along with adopting a healthy lifestyle, can decrease your risk of developing the serious or life-threatening complications of type 2 diabetes. These may include cardiovascular diseases, such as heart attack, stroke, and problems related to blood circulation; nerve damage; kidney disease; or eye conditions. Glucotrol is manufactured by Pfizer Pharmaceuticals and was approved by the Food and Drug Administration (FDA) in 1984. Glipizide Warnings You shouldn't take glipizide if you have type 1 diabetes (the body doesn't produce any insulin) or diabetic ketoacidosis (a dangerous condition that can occur if high blood sugar is untreated). Before taking this medicine, tell your doctor if you have or have ever had: G6PD deficiency (an inherited enzyme condition) Hormone disorders involving the pituitary, adrenal, or thyroid gland Heart, kidney, or liver disease Short-bowel syndrome (part of the intestine is removed or missing) Narrowing or a blockage of the intestines Ongoing diarrhea Tell your healthcare provider that you're taking glipizide before having any type of surgery, including a dental procedure. Some diabetes drugs may increase your risk of serious heart problems. However, blood sugars that are out of contr Continue reading >>
Glipizide, Metformin Hydrochloride:oral Tablet(5-500mg)
Alcohol may interfere with the actions of Antidiabetic agents (Insulin or other drugs used to treat Diabetes). Alcoholic beverages can increase the risk of low blood sugar, or can cause increased blood sugar due to the calories in these beverages. Limit alcohol containing medicines and beverages if you are on Antidiabetic Agents. You should also learn how to recognize the signs of low blood sugar. AlcoholandMetformin Hydrochloride(Metformin Hydrochloride) Alcohol may interfere with the actions of Antidiabetic agents (Insulin or other drugs used to treat Diabetes). Alcoholic beverages can increase the risk of low blood sugar, or can cause increased blood sugar due to the calories in these beverages. Limit alcohol containing medicines and beverages if you are on Antidiabetic Agents. You should also learn how to recognize the signs of low blood sugar. If you use tobacco or are trying to quit tobacco use, you may need to monitor your blood sugar more frequently. Nicotine, a component of tobacco, can increase the blood sugar. Also, if you are trying to quit smoking, as your body adjusts to not smoking, your blood sugar levels may change; the actions of Antidiabetic Agents (medicines used to treat diabetes) may be increased and this could lead to low blood sugar. Know the symptoms of low or high blood sugar and report them if they occur. Monitor your blood sugar regularly. Continue reading >>
How Glipizide Might Help With Your Type 2 Diabetes Management
Glipizide is an oral medication that is used to treat Type 2 diabetes. The drug is available in immediate-release tablets and extended-release tablets. Patients who currently take the medication as part of their diabetes treatment state that Glipizide has helped with lowering their blood sugar levels, and it seems that the extended-release tablets are favored over the immediate-release tablets. One of the main benefits from the drug is that it helps to lower your A1C levels by 1-2%. We will discuss the benefits and the downsides of Glipizide in more detail below. What is Glipizide? Glipizide is an oral medication used in the treatment of Type 2 diabetes. It is available in brand-name form as well as generic form, with the brand-names being Glucotrol and Glucotrol XL. Glipizide works by helping your pancreas produce more of your body’s natural insulin, which in turn regulates your blood sugar levels. Glipizide is used in conjunction with diet and exercise as part of a diabetes management plan. Glipizide is part of a class of diabetes drugs known as Sulfonylureas, which are designed to help your body’s pancreas to produce more of the body’s natural insulin. Diabetes medication aren’t designed to cure your Type 2 diabetes, but instead they are designed to treat the symptoms of diabetes, including blurry vision, excessive hunger, excessive thirst, frequent urination and sores that won’t heal. Further reading: Usually, the first diabetes medication that your doctor may prescribe is Metformin. However, many times, Glipizide is a popular choice for doctors to prescribe because many patients find that their bodies tolerate Glipizide better than Metformin. What are the Benefits of Glipizide? Glipizide can help lower your A1C levels by an average of 1-2%. Since Glipizid Continue reading >>
Glipizide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Glipizide is in a class of medications called sulfonylureas. Glipizide lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. Glipizide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated). Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes. Glipizide comes as tablets and extended-release (long-acting) tablets to take by mouth. The regular tablet is usually taken one or more times a day, 30 minutes before breakfast Continue reading >>
What Are The Possible Side Effects Of Glipizide And Metformin (metaglip)?
METAGLIP™ (glipizide and metformin HCl) Tablets 2.5 mg/250 mg 2.5 mg/500 mg 5 mg/500 mg DESCRIPTION METAGLIP™ (glipizide and metformin HCl) Tablets contain 2 oral antihyperglycemic drugs used in the management of type 2 diabetes, glipizide and metformin hydrochloride. Glipizide is an oral antihyperglycemic drug of the sulfonylurea class. The chemical name for glipizide is 1-cyclohexyl-3-[[p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl]sulfonyl]urea. Glipizide is a whitish, odorless powder with a molecular formula of C21H27N5O4S, a molecular weight of 445.55 and a pKa of 5.9. It is insoluble in water and alcohols, but soluble in 0.1 N NaOH; it is freely soluble in dimethylformamide. The structural formula is represented below. Metformin hydrochloride is an oral antihyperglycemic drug used in the management of type 2 diabetes. Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide monohydrochloride) is not chemically or pharmacologically related to sulfonylureas, thiazolidinediones, or α-glucosidase inhibitors. It is a white to off-white crystalline compound with a molecular formula of C4H12ClN5 (monohydrochloride) and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68. The structural formula is as shown: METAGLIP (glipizide and metformin) is available for oral administration in tablets containing 2.5 mg glipizide with 250 mg metformin hydrochloride, 2.5 mg glipizide with 500 mg metformin hydrochloride, and 5 mg glipizide with 500 mg metformin hydrochloride. In addition, each tablet contains the following inactive ingredients: microcrystalline cellulose, povidone, crosc Continue reading >>
Metaglip, (glipizide-metformin) Dosing, Indications, Interactions, Adverse Effects, And More
Discontinue metformin at the time of or before an iodinated contrast imaging procedure in patients with an eGFR between 30-60 mL/minute/1.73 m; in patients with a history of liver disease, alcoholism, or heart failure; or in patients who will be administered intra-arterial iodinate contrast Characterized by elevated blood lactate levels (>5 mmol/L) Rare but serious complication that can occur because of metformin accumulation; increased risk with sepsis, dehydration, excess alcohol intake, hepatic insufficiency, renal impairment, and acute congestive heart failure Subtle onset with nonspecific symptoms (eg, malaise, myalgias, respiratory distress, somnolence, nonspecific abdominal distress) Monitor lab for decreased serum pH, increased anion gap, and elevated blood lactate If suspected, discontinue drug and hospitalize patient immediately Metformin is highly dialyzable (clearance up to 170 mL/min under good hemodynamic conditions); prompt hemodialysis is recommended to correct the acidosis and to remove accumulated metformin Severe renal disease: eGFR <30 ml/min/1.73 m Metabolic acidosis, diabetic ketoacidosis Rare but serious lactic acidosis can occur due to accumulation of metformin Patients with glucose-6-phosphate dihydrogenase deficiency may be at risk of sulfonylurea induced hemolytic anemia Discontinue metformin at the time of or before an iodinated contrast imaging procedure in patients with an eGFR between 30-60 mL/minute/1.73 m; in patients with a history of liver disease, alcoholism, or heart failure; or in patients who will be administered intra-arterial iodinate contrast Reevaluate eGFR 48 hr after the imaging procedure; restart metformin if renal function is stable Continue reading >>
Glipizide And Metformin Overview
Glipizide/metformin is a prescription medication used in the management of type 2 diabetes mellitus. It is a single tablet containing 2 medications: glipizide and metformin. Glipizide belongs to a group of drugs called sulfonylureas. These work by stimulating the release of insulin from the pancreas. Metformin belongs to a group of drugs called biguanides. These work by decreasing the amount of glucose absorbed from food and decreasing the amount of glucose that is produced by the liver. This medication comes in tablet form and is taken once or twice daily with meals. Common side effects of glipizide/metformin include stomach pain, nausea or vomiting, diarrhea, and dizziness. Glipizide/metformin can also cause dizziness. Do not drive or operate heavy machinery until you know how glipizide/metformin affects you. Glipizide/metformin is a prescription medication used in the management of type 2 diabetes mellitus. It helps to lower the amount of glucose (sugar) in the blood. This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information. Continue reading >>