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Is Diabetes Hereditary Disease?

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Diabetes And Genetics

Tweet Genetics play a strong role in the chances of developing both type 1 and type 2 diabetes. Other factors include environment and lifestyle. Diabetes is an increasingly common chronic condition affecting millions of people in the UK alone. Diabetes and genetic risk The risk of developing diabetes is affected by whether your parents or siblings have diabetes. The likelihood of developing type 1 diabetes or type 2 diabetes differ, as you can see below. Type 1 diabetes and genetics - average risks Mother with diabetes increases risk of diabetes by 2% Father with diabetes increases risk of diabetes by 8% Both parents with diabetes increases risk by 30% Brother or sister with diabetes increases risk by 10% Non-identical twin with diabetes increases risk by 15% Identical twin with diabetes increases risk by 40% Type 2 diabetes and genetics - average risks If either mother of father has diabetes increases risk of diabetes by 15% If both mother and father have diabetes increases risk by 75% If non-identical twin has diabetes increases risk by 10% If identical twin has diabetes increases risk by 90% Some other forms of diabetes may be directly inherited, including maturity onset diabete Continue reading >>

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Popular Questions

  1. Rafique

    There are two types of diabetes mellitus.
    a. Type 1 diabetes mellitus b. Type 2 diabetes melliuts
    Is either of them a sex linked disease? Can either one be inherited? My book says, "this disease is transmitted as a recessive genetic characteristic." What does this mean?

  2. MCM

    Is either of them a sex linked disease? Can either one be inherited? My book says, "this disease is transmitted as a recessive genetic characteristic." What does this mean?
    Neither are sex-linked. Type 1 can be directly inherited (in a non-Mendelian fashion), but Type 2 genetic factors mostly increase risks. "Recessive genetic traits" are traits that only express themselves when ONLY the recessive alleles are present in the organism (a dominant allele, if present, will 'overpower' recessive one).
    Longer info:
    Diabetes mellitus Type 1 (Juvenile Diabetes) is inherited, but it is autosomal with complex dominant/recessive rules:
    Type 1 diabetes is a polygenic disease, meaning many different genes contribute to its onset. Depending on locus or combination of loci, it can be dominant, recessive, or somewhere in between.
    That results in some interesting, albeit complex, expressions:
    The risk of a child developing type 1 diabetes is about 10% if the father has it, about 10% if a sibling has it, about 4% if the mother has type 1 diabetes and was aged 25 or younger when the child was born, and about 1% if the mother was over 25 years old when the child was born.
    Diabetes mellitus Type 2 does have genetic components, but the vast majority merely increase the risk of developing Type 2 Diabetes. Environmental factors play a large role in Type 2.
    Excess body fat is associated with 30% of cases in those of Chinese and Japanese descent, 60-80% of cases in those of European and African descent, and 100% of Pima Indians and Pacific Islanders.

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