Insulin Potentiation Therapy In The Treatment Of Malignant Neoplastic Diseases: A Three Year Study
Oncology; Cancer treatment; Insulin potentiation targeted low dose; Low-dose chemotherapy A basic principle in the conventional administration of chemotherapy is the application of maximum tolerated doses at extended intervals of time. Despite the development of novel chemotherapeutics and varied combinations in numerous clinical trials, advancement has proven slow going and arduous. Difficulties such as poorly tolerated levels of toxicity, chemo resistance and an absence of significant prolongation of life expectancy are still unresolved. [ 1 - 3 ]. Efforts in the scientific community over the last decade or so, have led to a new strategy in the application of chemotherapeutics. So called metronomic chemotherapy involves the use of reduced doses of drugs at shorter intervals of time. Initial experimental and clinical results involving this strategy are promising and prompt further investigation [ 4 - 6 ]. A somewhat similar method in the application of chemotherapeutics likewise involves fractionated doses of conventional chemotherapeutics administered at short intervals. This method departs from the heretofore standard application of chemotherapy with the use of insulin as a biologic response modifier. Commonly referred to as Insulin Potentiation Therapy (IPT) or Insulin Potentiation Targeted Low Dose (IPTLD), this method facilitates the selective targeting of malignant cells while sparing normal tissues, resulting in greatly reduced treatment toxicity and improved quality of life as reported by patients [ 7 - 11 ]. Insulin Potentiation Therapy was developed in 1932 by the Mexican military physician Donato Perez Garcia, who reported anecdotal success in clinical practice over the course of three decades. A proposed theoretical mechanism of action was developed scient Continue reading >>
Insulin Potentiated Abx
has anyone ever heard of this Insulin Potentiated ABX. It's nice to have you back. From what I found on the Sloan-Kettering Cancer Center website.... "Insulin Potentiation Therapy (IPT) is a questionable cancer therapy that uses insulin to potentiate the effect of chemotherapy and other medications...." "...No clinical trials have been performed to validate these claims. In addition, the pharmacokinetic profiles on concurrent use of insulin and chemo drugs are lacking and it is unclear whether the insulin also potentiates the toxic effects of chemotherapy on healthy cells...." There are a few reports of it helping some with Lyme, but since there has only been one very small, short term study done on IPT and it was concerning breast cancer - not Lyme (in Uruguay) - and it did not look at survival, quality of life, well-being, or lasting effects - it isn't something I would encourage anyone to consider! Also, some are saying that it makes the Lyme go into it's cyst form and that's why some with Lyme are feeling better, and I haven't seen where any of those who tried it came back to say that they haven't had to use any thing else. It just sounds too dangerous, and we are already fighting to get the Lyme out of the cyst form! Continue reading >>
All Ipt - Insulin Potentiation Therapy Messages
David,I checked the list of Drs. There is only one listed for MO.Since I didn't look at a map I'm not sure if this is anywhere near your location. I am fortunate, if I decide to pursue this I have a Dr. available within about 20 miles. I understand that he has patients coming from New York and New Jersey. I doubt that the CTCA offers IPT, but could be wrong. I was told that there isnt an insurance co. that covers the treatment. I was also told that treatments run an average of $800.00 per visit and that about 10 visits are needed with possible follow-up as indicated. There is also a section on nutrition, which is quite helpful. I was also trying to find out if there were any clinical trials done. The book states that the NIH and NCI were supposed to be collaborating on a clinical trial. But I have not been able to find out any info to date.If you search for IPT treatment on the net you should be able to come up with additional info. I hope you receive the book shortly and that this will be of help to you. Wishing you the best of luck. Carol Thanks a million Carol!Springfield is about 300-350 mile from the Cape, but thats a lot better than California!If, and I stress IF, I can get my doctors to agree for me to use IPT I sure will try it!Yes, you are lucky to be that close to an IPT Physician. Would really like to convince my doctor to try IPT with the IMRT radiation treatment from CTCA and forgo the surgery!From all of my research think this, with some of the other approaches that are available; I might have a good chance of winning this one!Thanks again for your help!Good luck & God BlessDavid I'm not using IPT yet, but I meet with a doctor tomorrow morning about it. I have been talking to various doctors and oncologists at work (hospital/clinic) about the drugs and do Continue reading >>
Insulin Potentiation Therapy
Insulin is claimed to potentiate the effects of chemotherapy, enabling the use of much lower doses of chemotherapy. The mechanism of potentiation of chemotherapy is unclear. The effects of insulin potentiation therapy (IPT) on long-term survival have not been reported in peer-reviewed journals. Due to the lack of published studies, the safety of IPT is hard to judge but it has been associated with several risks. Insulin potentiation therapy (IPT) is a treatment regimen using insulin as an adjunct to conventional chemotherapy. It is claimed that insulin potentiates the effects of chemotherapy, which would enable a 75-90% reduction of the usual and customary doses of anticancer drugs thus reducing the risk of their adverse effects. Although some hypotheses have been put forward, the mechanisms of the claimed insulin potentiation of chemotherapy remain unclear and the few published in vitro studies do not help to clarify this. Clinical evidence is scarce, with only two small clinical trials and four cases published in peer-reviewed journals. Although they reported encouraging preliminary results on tumour growth, effects on patient survival or long-term effects have not been evaluated. IPT is associated with risks such as hypoglycaemia, and the reduced anticancer effects of lower doses of chemotherapeutic drugs potentially leading to drug resistance. IPT might even promote tumour growth. Overall, due to a lack of information published in peer-reviewed journals, it is impossible to judge the efficacy and safety of IPT. Scientific name(s)/brand name(s)/common name(s)/ingredient(s) In IPT, insulin is used as an adjunct to conventional chemotherapy. It is claimed that insulin potentiates the effects of chemotherapy, enabling the use of lower doses of the latter 1 . Insulin is Continue reading >>
Insulin Potentiation Therapy - Ipt - Alternative Cancer Chemotherapy That Is Gentle Without Side Effects
Available to patients today,with no need to wait years for government (FDA) approval. More than 70 years of successful use. With IPT, regular drugs act like "super" drugs,for treatment of many different diseases. These are observations that some IPT doctors have reported for many years. Supported by scientific papers, and reports from many doctors. However, despite more than 140 years of cumulative reported IPT success, and billions of dollars spent on other medical research, no clinical or laboratory research on IPT has been done or funded... yet. IPT deserves laboratory studies and clinical trials. "The second discovery of insulin." IPT is insulin potentiation therapy, a non-diabetic use of the hormone insulin to dramatically improve effectiveness and delivery of standard medications. IPT has an outstanding 135 doctor-year track record (115 years for cancer) over 72 years, and is ready for clinical trials and widespread use. Cancer treatment with IPT is reported to be gentler, safer, more effective, and less expensive, with no surgery, no radiation, and usually no side effects. Breakthrough results have also been reported for arthritis, as well as for infectious, respiratory, cardiovascular, neurological, and other diseases. This slight modification of standard medicine could help many medications act like super drugs, with better results for many millions of patients. The US National Institutes of Health has expressed interest in clinical trials of IPT for cancer, but has so far provided no funding. Discovered in 1926 by Donato Perez Garcia MD, fostered by his son and grandson, with 140+ doctor-years of experience over 72 years, yet still unknown by the world, IPT is just starting a scientific and clinical rebirth. IPT = Insulin Potentiation Therapy Q = Quest, Quest Continue reading >>
Insulin Potentiated Abx
has anyone ever heard of this Insulin Potentiated ABX. It's nice to have you back. From what I found on the Sloan-Kettering Cancer Center website.... "Insulin Potentiation Therapy (IPT) is a questionable cancer therapy that uses insulin to potentiate the effect of chemotherapy and other medications...." "...No clinical trials have been performed to validate these claims. In addition, the pharmacokinetic profiles on concurrent use of insulin and chemo drugs are lacking and it is unclear whether the insulin also potentiates the toxic effects of chemotherapy on healthy cells...." There are a few reports of it helping some with Lyme, but since there has only been one very small, short term study done on IPT and it was concerning breast cancer - not Lyme (in Uruguay) - and it did not look at survival, quality of life, well-being, or lasting effects - it isn't something I would encourage anyone to consider! Also, some are saying that it makes the Lyme go into it's cyst form and that's why some with Lyme are feeling better, and I haven't seen where any of those who tried it came back to say that they haven't had to use any thing else. It just sounds too dangerous, and we are already fighting to get the Lyme out of the cyst form! Continue reading >>
Does Anyone Know Anything About Ipt?
No, I havent registered yet register now By creating an account I accept Cancer Chat Terms & Conditions . Thanks for taking the time to read this. My Aunt was diagnosed with breast cancer last year and had a double-mastectomy. She was undergoing chemotherapy and appears to be progressing appropriately. I have since learned more about chemotherapy and I came across a hybrid treatment of sorts called Insulin Potentiated Therapy (IPT) . Have you heard of it? I tried finding forums, blogs and more about it for reviews, but I can't really locate anything? I did find an alternative cancer treatment centre (with lots of FAQs and similar) - but I still want to read "real patient" reviews. Do you know of any places I can learn more? From what I gather it is a mix of low-dose chemo and natural mixtures of nutrients meant to kill the cancer, while not going overboard and hurting other parts of your body. The reason I am interesting in this option is because I know chemo is so hard on the body. From the sounds of it, it's weakening, sickening and can outright hurt you. That being said, I understand the need for it and how it is one of (if not the best) option for killing cancer. So an option like this makes sense to me (not a Doctor, obviously) and I wanted to learn more. Thanks in advance and I appreciate your help pushing me in the right direction. 13 Jan 2014 21:51 in response to JillianOwens Have looked online and there are quite a few sites that give information about IPT - just put Insulin Potentiated Therapy in Google. I suggest you go on the Quackwatch site as it shows the dangers of this 'medication'. If your Aunt is responding well to conventional chemotherapy, in my opinion, you would be looking after her interests more if she continues with the course of treatment she Continue reading >>
Insulin Potentiation Therapy
Our medical policies are designed for informational purposes only and are not an authorization, or an explanation of benefits, or a contract. Receipt of benefits is subject to satisfaction of all terms and conditions of the coverage. Medical technology is constantly changing, and we reserve the right to review and update our policies periodically. Insulin potentiation therapy (IPT) uses insulin as an adjunctive agent to potentiate the effects of pharmacologic therapy in the treatment of cancer, infectious diseases, chronic degenerative disorders, and many other conditions. The observation that some cancer cells may express a greater number of insulin receptors has been the basis of the hypothesis for IPT. The physiologic effects of insulin in IPT are thought to increase the permeability of cell membranes and facilitate increased intracellular absorption of pharmacologic agents. Theoretically, the increased absorption of a pharmacologic agent results in higher intracellular drug concentrations; lower dosage requirements could then reduce toxicity and adverse side effects. IPT was developed in the 1930s in Mexico by Donato Perez Garcia, Sr., MD. It is primarily used in the treatment of cancer, for which increasing the intracellular concentration and cytotoxic effects of chemotherapy agents while decreasing the adverse effects is thought to increase antitumoral activity and patient tolerance to treatment. There have been proponents of using IPT for other conditions as well, such as infectious diseases, chronic degenerative disorders, chronic fatigue syndrome and fibromyalgia. For cancer patients, a hypoglycemic state is induced in the minutes prior to infusion with standard chemotherapy delivered at sub-therapeutic doses. During this time, the patient may experience moder Continue reading >>
Ipt Here's The Science! - Weeksmd
CHRONOLOGY OF EVENTS IN THE SCIENTIFIC EVALUATION OF IPT AND THE TREATMENT OF CANCER October 1989: Poster presentation at the Forty-second Annual Symposium on Fundamental Cancer Research, The University of Texas, M.D. Anderson Cancer Center entitled Breast carcinoma treated by a regimen of low-dose chemotherapy and insulin: report of four cases and pharmacokinetic considerations. December l990: Publication in the European Journal of Cancer (letter) entitled Neoadjuvant low-dose chemotherapy with insulin in breast carcinomas (Eur. J Cancer, 26, 1262-1263, 1990). February 1991: Oral presentation at the Third International Congress on Neoadjuvant Chemotherapy, , February 6-9, 1991. Title: Insulin plus low-dose CMF as neoadjuvant chemo-hormonal therapy for breast carcinomas. A write-up of this talk appeared in the July-August 1991 issue of Oncology News (Vol. 17, No. 4). June 1991: Began correspondence with Reps. Patricia Schroeder & Constance Morella, co-chairpersons of the Congressional Caucus on Womens Issues in response to their Breast Cancer Challenge which was issued to the medical profession in June, 1991. The Breast Cancer Challenge charged American researchers and physicians to come up with an effective treatment for breast cancer by the year 2000. July 18, 1991: Sent a letter to Susan Love, M.D. of the , informing her of IPT and its possible safety and efficacy in the neoadjuvant chemohormonal treatment of breast cancer. Dr. Love is the chief medical spokesperson for the Breast Cancer Coalition. October 1991: As a result of the correspondence with the Breast Cancer Challenge, I received a copy of a letter from Bernadine Healy, M.D., Director, National Institutes of Health, addressed to Rep. Constance Morella (Dated October 23, 1991). This letter discussed IPT, an Continue reading >>
Insulin Potentiation Therapy
Insulin potentiation therapy (IPT) is an unproven alternative cancer treatment using insulin as an adjunct to low-dose chemotherapy.[1] According to Quackwatch, "Insulin Potentiation Therapy (IPT) is one of several unproven, dangerous treatments that is promoted by a small group of practitioners without trustworthy evidence that it works."[2] History[edit] It was developed by Donato Perez Garcia, MD in 1930. Originally, Garcia targeted syphilis, and later tried the treatment for chronic degenerative diseases and some types of cancer.[3] Method[edit] Generally, a dose of insulin is injected into a vein, followed by a low dose of chemotherapy drugs when the insulin has been absorbed. The chemotherapy dose is usually 10% to 25% of the proven dose.[3] Then sugar water is injected to stop the hypoglycemia (low blood sugar) caused by the insulin injection.[3] Efficacy[edit] IPT has not been proven to work.[3][4] Long-term outcomes, such as survival, have never been published.[3] Four individual case studies, one small, uncontrolled clinical trial and one small prospective, randomized controlled trial have shown temporary reductions in the size of tumors for some patients.[3] Adverse effects[edit] The immediate risk is hypoglycemia.[3] The use of lower than normal doses of chemotherapy can cause drug resistance, which could make future treatment at standard, proven doses ineffective.[3] For some cancers, especially breast and colon cancers, insulin may promote tumor growth.[3] Mechanism of action[edit] Two main ideas about how it might work have been proposed. The first idea is that insulin makes cells more permeable, so that the chemotherapy drugs are absorbed faster into cells. The other idea is that insulin might cause the cells to start dividing, which makes them more susc Continue reading >>
Ralph Mosscancer Consultant: Does Insulin Potentiated Therapy Work?
Insulin potentiation therapy (IPT) is a very popular form of cancer treatment. Also called insulin-potentiated targeted low-dose (IPTLD) therapy, it is very attractive to patients, since it promises to attain the beneficial effects of full-strength chemotherapy, but with virtually no toxicity. The efficacy of the chemotherapy is allegedly greatly enhanced by co-administration of the hormone insulin. The dose of chemo given in IPT is typically in the 10 to 15 percent of normal range, sometimes with shorter-than-normal intervals between treatments. Insulin is truly a magic bullet cancer treatment, meaning it allows chemotherapy to target cancer cells and results in far less side-effects.( ) The administration of insulin will lower blood sugar. Depending on the dose, this will put some people at risk of hypoglycemia. In the worst case scenario, this cut cause insulin shock, in which case the patient becomes unconscious due to a too low blood sugar level. You may think this is unlikely to happen, but in 2000 I actually saw patients being put into insulin shock at a Tijuana cancer clinic. Thankfully, within days the Mexican health authorities permanently shut down that clinic. All sorts of claims are made for the efficacy of IPT or IPTLD, but where is the proof? I was on the NIH panel (the Cancer Advisory Panel on Complementary and Alternative Therapies, or CAPCAM) to which the proponents of IPT submitted some of their best cases on September 18, 2000. In my opinion, the presentation was a failure, since they did not present a single case in which a remission from cancer could reasonably be ascribed to IPT. At the time I pointed out that I, and the other members of the panel, had every reason to want them to give a successful presentation, but that they had failed to do so. Continue reading >>
Insulin Potentiation Therapy - Welcome To Cancer Cure Foundation
Information from Steven Ayre's website: Chemotherapy drugs are powerful cell-killing agents. In current medical practice, getting these drugs into the inside of cells where they do their work requires that they be administered in doses high enough to force them across the membranes of cancer cells. A major drawback to this dosing strategy is a serious dose-related side effect profile frequently seen with anticancer drugs. This happens because chemotherapy agents do not discriminate between cancer cells and other normal cells in the patient's body. They kill both kinds of cells, therefore there are side effects. With recent advances in our understanding of the inner workings of cancer cells, it is now possible to avoid the dose-related side effects of chemotherapy, while at the same time increasing the effectiveness and specificity of these agents in killing cancer cells. The key to this is an innovative strategy for drug delivery called Insulin Potentiation Therapy (IPT). Readers will recognize insulin as being the hormone used to treat diabetes. Secreted by the pancreas in healthy people, insulin is a powerful hormone with many actions in the human body, a principal one being to manage the delivery of glucose across cell membranes into cells. Insulin communicates its messages to cells by joining up with specific insulin receptors scattered on the outer surface of the cell membranes. Every cell in the human body has some of these receptors, with there being from one hundred to one hundred thousand of them per cell. One might well ask, "What does any of this have to do with cancer cells?" It is a well-known scientific fact that cancer cells have a voracious appetite for glucose. Glucose is their unique source of energy, and because of the relatively inefficient way canc Continue reading >>
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Insulin Potentiation Therapy: A New Concept In The Management Of Chronic Degenerative Disease
Volume 20, Issue 2 , June 1986, Pages 199-210 Insulin potentiation therapy: A new concept in the management of chronic degenerative disease Get rights and content In insulin potentiation therapy the hormone insulin is used as an adjunct in the medical management of the chronic degenerative diseases including malignant neoplasia. In this, the recognized physiological action of insulin that of increasing cell membrane permeability is taken advantage of to potentiate the pharmacological actions of medications administered concurrently in the therapy. This potentiation occurs because of the heretofore unrecognized applicability of this membrane permeabilizing effect of insulin to a much wider range of tissues than is classicly accepted, and further the observed effect of this permeabilizing phenomenon as it relates to drug molecules, most importantly the antineoplastic agents. The historical context of insulin potentiation therapy is described, and scientific corroboration for its novel hypotheses is given. Insulin potentiation therapy represents a potentially revolutionary concept in the medical management of diseases and is, in the authors' opinion, deserving of intensive scientific investigation through in vitro and in vivo experimentation and properly conducted human clinical trials in a university teaching hospital setting. Continue reading >>
Low-dose Chemotherapy With Insulin (insulin Potentiation Therapy) In Combination With Hormone Therapy For Treatment Of Castration-resistant Prostate Cancer
Low-Dose Chemotherapy with Insulin (Insulin Potentiation Therapy) in Combination with Hormone Therapy for Treatment of Castration-Resistant Prostate Cancer Medical Center Integrative Medicine, Deliiska Vodenitza Street, Bl. 330, 1592 Sofia, Bulgaria Received 2012 Jan 20; Accepted 2012 Feb 16. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC. Purpose. To evaluate the results and quality of life of patients with resistant of castration-resistant tumors previously treated with Insulin-potentiation therapy (IPT) combined with hormone therapy. Materials and methods. Sixteen patients with metastasis prostate tumors after bilateral castration, androgenic blockade, and progression of the disease were observed during the study. The patients were divided into two groups: group A consisting of 8 patients treated with low-dose chemotherapy Epirubicin, Vinblastine, and Cyclophosphamide combined with LHRH agonist and group B consisting of another 8 patients treated with low-dose chemotherapy Docetaxel combined with LHRH agonist. Results. The overall (groups A and B) results concerning PSA after the sixth IPT show partial effect in 8 out of 16 (50%) patients, stabilization in 4 out of 16 (25%), and progression in 4 out of 16 (25%). The median survival for all treated patients is 11,7 months (range 330 months). During the treatment no significant side effects were observed, and no lethal cases occurred. Conclusion. In spite of the small number of the treated patients with castration-resistant prostate tumors, the preliminary results are promising and this gives us hope Continue reading >>
References And Articles | Official Website Of Insulin Potentiation Therapy
Official Website Of Insulin Potentiation Therapy NIH Bethesda, Maryland. 3rd reunion from cancer advisory panel for the National Center for Complementary and Alternative Medicine. Presenters: Ayre S.G., Donato Prez Garca Belln, Donato Prez Garca, Hauser R. (Invited by Jeff Whit, MD.) Patient summaries for the insulin potentiation therapy best case series NIH, Bethesda, Maryland. Organized by: The National Institutes of Healths office of Alternative Medicine (OAM) and The National Cancer Institute (NCI). Presenters: Ayre S.G., Donato Prez Garca Belln, Donato Prez Garca. Insulin Potentiation Therapy Best case series approach Practice Outcomes Monitoring and Evaluation System (POMES) for integrated complementary and alternative medicine cancer practices. Washington D.C., Presentation at the third annual comprehensive cancer management conference. By S.G.A. Primary breast conserving treatment for breast cancer using biologic response modification with insulin in combination with non-toxic low-dose chemotherapy. February, 6-9, 1991, Paris, France. The 3rd International Congress on Neo Adjuvant Chemotherapy. Participants: S.G.A, M.D, Donato Prez Garca Belln, M.D, Donato Prez Garca Jr. , M.D. Insulin Plus Low-Dose CMF as Neo-Adjuvant Chemo Hormonal Therapy for Breast Carcinoma. October 24-27, 1989, University of Texas, Houston. Poster abstract at 42 nd Annual Symposium on Fundamental Cancer Center. By: S.G.A, Donato Prez Garca y Belln, Donato Prez Garca Jr. Breast Carcinoma Treated by a Regimen of Low-Dose Chemotherapy and Insulin: Report of 4 cases and Pharmacokinetic Considerations. August 4-6, 1997, Bethesda , Maryland, Medical Hypotheses (20(2):199-210,1986) By: SGA, Donato Prez Garca Belln and Donato Prez Garca , Jr.Insulin Potentiation Therapy: a new concept for managem Continue reading >>
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- Comparative Effectiveness and Costs of Insulin Pump Therapy for Diabetes
