diabetestalk.net

Insulin Degludec And Liraglutide Storage

Novo Nordisk Receives Fda Approval For Xultophy® 100/3.6 (insulin Degludec And Liraglutide Injection)

Novo Nordisk Receives Fda Approval For Xultophy® 100/3.6 (insulin Degludec And Liraglutide Injection)

New combination therapy offers reductions in A1C for adults with Type 2 diabetes who are inadequately controlled on basal insulin (less than 50 units) daily or liraglutide (less than or equal to 1.8 mg) daily ® 100/3.6 (insulin degludec 100 units/mL and liraglutide 3.6 mg/mL injection). Xultophy® 100/3.6 is a once-daily, combination of Tresiba® (insulin degludec injection) and Victoza® (liraglutide) injection indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes inadequately controlled on less than 50 units of basal insulin daily or less than or equal to 1.8 mg of liraglutide daily.1 Xultophy® 100/3.6 enters into a new class of diabetes treatments that combine a basal insulin and a glucagon-like peptide-1 receptor agonist (GLP-1 RA) in a single, once-daily injection. "Novo Nordisk is committed to discovering and developing new medicines, like Xultophy® 100/3.6, that may make a difference in the way some adults with type 2 diabetes manage their diabetes and achieve their treatment goals," said Jakob Riis, executive vice president and head of North America Operations, Novo Nordisk A/S. "Combining Tresiba® and Victoza® into a single injection will offer patients a new option that may help control their blood sugar. We look forward to making Xultophy® 100/3.6 available to adults with type 2 diabetes in the first half of 2017." The approval of Xultophy® 100/3.6 is based on efficacy and safety data from the DUAL™ (Dual Action of Liraglutide and Insulin Degludec in Type 2 Diabetes) clinical development program. In three DUAL™ trials involving 1,393 adults with type 2 diabetes, patients who were inadequately controlled on liraglutide or basal insulin therapy and switched to Xultophy® 100/3.6 achieved reductions in Continue reading >>

Insulin Degludec And Liraglutide

Insulin Degludec And Liraglutide

Pronunciation: IN su lin de GLOO dek and LIR a GLOO tide What is the most important information I should know about insulin degludec and liraglutide? You should not use this medicine if you have multiple endocrine neoplasia type 2 (tumors in your glands), a personal or family history of medullary thyroid cancer, insulin-dependent diabetes, or if you are having an episode of low blood sugar or diabetic ketoacidosis. In animal studies, liraglutide caused thyroid tumors or thyroid cancer. It is not known whether these effects would occur in people. Call your doctor at once if you have signs of a thyroid tumor, such as swelling or a lump in your neck, trouble swallowing, a hoarse voice, or shortness of breath. What is insulin degludec and liraglutide? Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Insulin degludec is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. Liraglutide is similar to a hormone that occurs naturally in the body and helps control blood sugar, insulin levels, and digestion. Insulin degludec and liraglutide is a combination medicine used to lower blood sugar in adults with type 2 diabetes mellitus. This medicine should be used together with diet and exercise. Insulin degludec and liraglutide is usually given when your blood sugar levels have not been well controlled by using other medications. Insulin degludec and liraglutide is not for people with type 1 diabetes. Insulin degludec and liraglutide may also be used for purposes not listed in this medication guide. What should I discuss with my healthcare provider before taking insulin degludec and liraglutide? You should not use this medicine if you are allergic to insulin or liraglutide. Do not use this me Continue reading >>

Insulin Degludec And Liraglutide

Insulin Degludec And Liraglutide

Pronunciation: IN su lin de GLOO dek and LIR a GLOO tide What is the most important information I should know about insulin degludec and liraglutide? You should not use this medicine if you have multiple endocrine neoplasia type 2 (tumors in your glands), a personal or family history of medullary thyroid cancer, insulin-dependent diabetes, or if you are having an episode of low blood sugar or diabetic ketoacidosis. In animal studies, liraglutide caused thyroid tumors or thyroid cancer. It is not known whether these effects would occur in people. Call your doctor at once if you have signs of a thyroid tumor, such as swelling or a lump in your neck, trouble swallowing, a hoarse voice, or shortness of breath. What is insulin degludec and liraglutide? Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Insulin degludec is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. Liraglutide is similar to a hormone that occurs naturally in the body and helps control blood sugar, insulin levels, and digestion. Insulin degludec and liraglutide is a combination medicine used to lower blood sugar in adults with type 2 diabetes mellitus. This medicine should be used together with diet and exercise. Insulin degludec and liraglutide is usually given when your blood sugar levels have not been well controlled by using other medications. Insulin degludec and liraglutide is not for people with type 1 diabetes. Insulin degludec and liraglutide may also be used for purposes not listed in this medication guide. What should I discuss with my healthcare provider before taking insulin degludec and liraglutide? You should not use this medicine if you are allergic to insulin or liraglutide. Do not use this me Continue reading >>

Xultophy 100/3.6 (insulin Degludec/liraglutide) Dose, Indications, Adverse Effects, Interactions... From Pdr.net

Xultophy 100/3.6 (insulin Degludec/liraglutide) Dose, Indications, Adverse Effects, Interactions... From Pdr.net

Xultophy Subcutaneous Inj Sol: 1mL, 100-3.6mg For the treatment of type 2 diabetes mellitus for adults who are inadequately controlled on basal insulin (less than 50 units daily) or liraglutide (less than or equal to 1.8 mg daily). Insulin degludec; liraglutide (Xultophy) is administered as dose units. The pre-filled pen can provide from 10 up to 50 dose units in a single injection in increments of 1 dose unit. Discontinue therapy with liraglutide or basal insulin prior to initiation of Xultophy. RECOMMENDED STARTING DOSE: 16 dose units (16 units of insulin degludec and 0.58 mg of liraglutide) subcutaneously once daily at the same time each day, with or without food. DOSE TITRATION: Titrate the dosage upwards or downwards by 2 dose units (2 units of insulin degludec and 0.072 mg of liraglutide) every 3 to 4 days based on the patients metabolic needs, blood glucose monitoring results, and glycemic control goal until the desired fasting plasma glucose is achieved. May temporarily titrate below 16 dose units if needed. However, if the patient requires a dose that is persistently below 16 dose units or requires a dose above 50 dose units, use alternative antidiabetic products. MAX: 50 dose units (50 units insulin degludec and 1.8 mg liraglutide). MISSED DOSE: Instruct patients who miss a dose to resume the once-daily regimen as prescribed with the next scheduled dose; do not administer an extra dose or increase the dose to make up for the missed dose. If more than 3 days have elapsed since the last dose, reinitiate Xultophy at the starting dose (i.e., 16 dose units once daily) to mitigate any gastrointestinal symptoms associated with re-initiation of treatment. Not recommended as first-line initial therapy. Do not use in combination with any other product containing liragl Continue reading >>

Insulin Degludec And Liraglutide

Insulin Degludec And Liraglutide

Pronunciation: IN su lin de GLOO dek and LIR a GLOO tide What is the most important information I should know about insulin degludec and liraglutide? You should not use this medicine if you have multiple endocrine neoplasia type 2 (tumors in your glands), a personal or family history of medullary thyroid cancer, insulin-dependent diabetes, or if you are having an episode of low blood sugar or diabetic ketoacidosis. In animal studies, liraglutide caused thyroid tumors or thyroid cancer. It is not known whether these effects would occur in people. Call your doctor at once if you have signs of a thyroid tumor, such as swelling or a lump in your neck, trouble swallowing, a hoarse voice, or shortness of breath. What is insulin degludec and liraglutide? Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Insulin degludec is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. Liraglutide is similar to a hormone that occurs naturally in the body and helps control blood sugar, insulin levels, and digestion. Insulin degludec and liraglutide is a combination medicine used to lower blood sugar in adults with type 2 diabetes mellitus. This medicine should be used together with diet and exercise. Insulin degludec and liraglutide is usually given when your blood sugar levels have not been well controlled by using other medications. Insulin degludec and liraglutide is not for people with type 1 diabetes. Insulin degludec and liraglutide may also be used for purposes not listed in this medication guide. What should I discuss with my healthcare provider before taking insulin degludec and liraglutide? You should not use this medicine if you are allergic to insulin or liraglutide. Do not use this me Continue reading >>

Insulin Degludec And Liraglutide

Insulin Degludec And Liraglutide

An arrowing pointing forward, usually indicating forward movement, or the ability the share something via social media. An icon showing an uppercase letter "X", indicating that this will close the current element. This drug has been shown to cause thyroid cancer in some animals. It is not known if this happens in humans. If thyroid cancer happens, it may be deadly if not found and treated early. Call your doctor right away if you have a neck mass, trouble breathing, trouble swallowing, or have hoarseness that will not go away. Do not use this drug if you have a health problem called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), or if you or a family member have had thyroid cancer. It is used to lower blood sugar in patients with high blood sugar (diabetes). What do I need to tell my doctor BEFORE I take this drug? If you have an allergy to this drug or any part of this drug. If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have any of these health problems: Acidic blood problem or type 1 diabetes. If you are using another drug that has the same drug in it. If you are using any of these drugs: Albiglutide, dulaglutide, exenatide, or lixisenatide. If you are breast-feeding. Do not breast-feed while you take this drug. This is not a list of all drugs or health problems that interact with this drug. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health probl Continue reading >>

Liraglutide/insulin Degludec (rx)

Liraglutide/insulin Degludec (rx)

Dosing & Uses Type 2 Diabetes Mellitus Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus who are inadequately controlled on basal insulin (<50 units/day) or liraglutide (≤1.8 mg/day) Recommended starting dose: 16 units (ie, 16 units insulin degludec and 0.58 mg liraglutide) SC qDay Maximum daily dose: 50 units (50 units of insulin degludec and 1.8 mg of liraglutide) The pen delivers doses from 10-50 units with each injection Each dosage unit contains 1 unit of insulin degludec and 0.036 mg of liraglutide Use alternative antidiabetic products if patients require a daily dosage persistently below 16 units or over 50 units May titrate dose upwards or downwards by 2 units every 3-4 days based on the patient’s metabolic needs, blood glucose monitoring results, and glycemic control goal until the desired fasting plasma glucose is achieved May be temporarily down-titrated to <16 units (ie, 10-15 units); however, if persistent dosages <16 units required, discontinue and use alternative therapy To minimize the risk of hypoglycemia or hyperglycemia, additional titration may be needed Changes in physical activity, meal patterns (ie, macronutrient content or timing of food intake), or renal or hepatic function During acute illness When used with other medications Dosage Modifications Severe (liraglutide/insulin degludec): Not studied Liraglutide: Postmarketing reports in patients with severe renal impairment of acute renal failure and worsening of chronic renal failure, which may sometimes require hemodialysis Dosing Considerations Limitations of use Not recommended as first-line therapy for patients who have inadequate glycemic control on diet and exercise because of the uncertain relevance of the rodent C-cell tum Continue reading >>

Storage & Travel

Storage & Travel

Do not take Tresiba® if you: are having an episode of low blood sugar are allergic to Tresiba® or any of the ingredients in Tresiba® Before taking Tresiba®, tell your health care provider about all your medical conditions, including if you are: pregnant, planning to become pregnant, or are breastfeeding taking new prescription or over-the-counter medicines, vitamins, or herbal supplements Talk to your health care provider about low blood sugar and how to manage it. Read the Instructions for Use and take Tresiba® exactly as your health care provider tells you to Do not do any conversion of your dose. The dose counter always shows the selected dose in units Know the type and strength of insulin you take. Do not change the type of insulin you take unless your health care provider tells you to Do not take Tresiba® if you: are having an episode of low blood sugar are allergic to Tresiba® or any of the ingredients in Tresiba® Before taking Tresiba®, tell your health care provider about all your medical conditions, including if you are: pregnant, planning to become pregnant, or are breastfeeding taking new prescription or over-the-counter medicines, vitamins, or herbal supplements Talk to your health care provider about low blood sugar and how to manage it. Read the Instructions for Use and take Tresiba® exactly as your health care provider tells you to Do not do any conversion of your dose. The dose counter always shows the selected dose in units Know the type and strength of insulin you take. Do not change the type of insulin you take unless your health care provider tells you to Adults - If you miss or are delayed in taking your dose of Tresiba®: Take your dose as soon as you remember, then continue with your regular dosing schedule Make sure there are at least 8 Continue reading >>

Insulin Degludec And Liraglutide (subcutaneous Route)

Insulin Degludec And Liraglutide (subcutaneous Route)

A nurse or other trained health professional may give you this medicine. You may also be taught how to give your medicine at home. This medicine is given as a shot under your skin. Always double-check both the concentration (strength) of your insulin and your dose. Concentration and dose are not the same. The dose is how many units of insulin you will use. The concentration tells how many units of insulin are in each milliliter (mL), such as 100 units/mL (U-100), but this does not mean you will use 100 units at a time. Each package of Xultophy contains a patient information sheet. Read this sheet carefully and make sure you understand: How to dispose of syringes, needles, and injection devices. It is best to use a different place on the body for each injection (eg, under the skin of your abdomen or stomach, thigh, or upper arm). If you have questions about this, contact a member of your health care team. Since this medicine lowers the blood glucose over 24 hours, it is best to use it at about the same time every day. The insulin solution should look clear and colorless. Do not use this medicine if it is cloudy or thickened. Follow carefully the special meal plan your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take Continue reading >>

Insulin Degludec And Liraglutide

Insulin Degludec And Liraglutide

Pronunciation: IN su lin de GLOO dek and LIR a GLOO tide What is the most important information I should know about insulin degludec and liraglutide? You should not use this medicine if you have multiple endocrine neoplasia type 2 (tumors in your glands), a personal or family history of medullary thyroid cancer, insulin-dependent diabetes, or if you are having an episode of low blood sugar or diabetic ketoacidosis. In animal studies, liraglutide caused thyroid tumors or thyroid cancer. It is not known whether these effects would occur in people. Call your doctor at once if you have signs of a thyroid tumor, such as swelling or a lump in your neck, trouble swallowing, a hoarse voice, or shortness of breath. What is insulin degludec and liraglutide? Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Insulin degludec is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. Liraglutide is similar to a hormone that occurs naturally in the body and helps control blood sugar, insulin levels, and digestion. Insulin degludec and liraglutide is a combination medicine used to lower blood sugar in adults with type 2 diabetes mellitus. This medicine should be used together with diet and exercise. Insulin degludec and liraglutide is usually given when your blood sugar levels have not been well controlled by using other medications. Insulin degludec and liraglutide is not for people with type 1 diabetes. Insulin degludec and liraglutide may also be used for purposes not listed in this medication guide. What should I discuss with my healthcare provider before taking insulin degludec and liraglutide? You should not use this medicine if you are allergic to insulin or liraglutide. Do not use this me Continue reading >>

Insulin Degludec And Liraglutide

Insulin Degludec And Liraglutide

Pronunciation: IN su lin de GLOO dek and LIR a GLOO tide What is the most important information I should know about insulin degludec and liraglutide? You should not use this medicine if you have multiple endocrine neoplasia type 2 (tumors in your glands), a personal or family history of medullary thyroid cancer, insulin-dependent diabetes, or if you are having an episode of low blood sugar or diabetic ketoacidosis. In animal studies, liraglutide caused thyroid tumors or thyroid cancer. It is not known whether these effects would occur in people. Call your doctor at once if you have signs of a thyroid tumor, such as swelling or a lump in your neck, trouble swallowing, a hoarse voice, or shortness of breath. What is insulin degludec and liraglutide? Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Insulin degludec is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. Liraglutide is similar to a hormone that occurs naturally in the body and helps control blood sugar, insulin levels, and digestion. Insulin degludec and liraglutide is a combination medicine used to lower blood sugar in adults with type 2 diabetes mellitus. This medicine should be used together with diet and exercise. Insulin degludec and liraglutide is usually given when your blood sugar levels have not been well controlled by using other medications. Insulin degludec and liraglutide is not for people with type 1 diabetes. Insulin degludec and liraglutide may also be used for purposes not listed in this medication guide. What should I discuss with my healthcare provider before taking insulin degludec and liraglutide? You should not use this medicine if you are allergic to insulin or liraglutide. Do not use this me Continue reading >>

Insulin Degludec And Liraglutide

Insulin Degludec And Liraglutide

Pronunciation: IN su lin de GLOO dek and LIR a GLOO tide What is the most important information I should know about insulin degludec and liraglutide? You should not use this medicine if you have multiple endocrine neoplasia type 2 (tumors in your glands), a personal or family history of medullary thyroid cancer, insulin-dependent diabetes, or if you are having an episode of low blood sugar or diabetic ketoacidosis. In animal studies, liraglutide caused thyroid tumors or thyroid cancer. It is not known whether these effects would occur in people. Call your doctor at once if you have signs of a thyroid tumor, such as swelling or a lump in your neck, trouble swallowing, a hoarse voice, or shortness of breath. What is insulin degludec and liraglutide? Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Insulin degludec is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. Liraglutide is similar to a hormone that occurs naturally in the body and helps control blood sugar, insulin levels, and digestion. Insulin degludec and liraglutide is a combination medicine used to lower blood sugar in adults with type 2 diabetes mellitus. This medicine should be used together with diet and exercise. Insulin degludec and liraglutide is usually given when your blood sugar levels have not been well controlled by using other medications. Insulin degludec and liraglutide is not for people with type 1 diabetes. Insulin degludec and liraglutide may also be used for purposes not listed in this medication guide. What should I discuss with my healthcare provider before taking insulin degludec and liraglutide? You should not use this medicine if you are allergic to insulin or liraglutide. Do not use this me Continue reading >>

Insulin Degludec And Liraglutide

Insulin Degludec And Liraglutide

What is insulin degludec and liraglutide? Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Insulin degludec is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. Liraglutide is similar to a hormone that occurs naturally in the body and helps control blood sugar, insulin levels, and digestion. Insulin degludec and liraglutide is a combination medicine used to lower blood sugar in adults with type 2 diabetes mellitus . This medicine should be used together with diet and exercise. Insulin degludec and liraglutide is usually given when your blood sugar levels have not been well controlled by using other medications. Insulin degludec and liraglutide is not for people with type 1 diabetes . Insulin degludec and liraglutide may also be used for purposes not listed in this medication guide. Aging Issues: 12 of the Most Common Health Concerns Affecting Seniors You should not use this medicine if you have multiple endocrine neoplasia type 2 (tumors in your glands), a personal or family history of medullary thyroid cancer , insulin-dependent diabetes, or if you are having an episode of low blood sugar or diabetic ketoacidosis . In animal studies, liraglutide caused thyroid tumors or thyroid cancer . It is not known whether these effects would occur in people. Call your doctor at once if you have signs of a thyroid tumor, such as swelling or a lump in your neck, trouble swallowing, a hoarse voice, or shortness of breath. You should not use this medicine if you are allergic to insulin or liraglutide. Do not use this medicine during an episode of low blood sugar, or if you have: multiple endocrine neoplasia type 2 (tumors in your glands); a personal or family history of medullary thyroid c Continue reading >>

Insulin Degludec And Liraglutide (subcutaneous Route)

Insulin Degludec And Liraglutide (subcutaneous Route)

Insulin degludec and liraglutide combination is used to treat a type of diabetes mellitus (sugar diabetes) called type 2 diabetes. Insulin degludec is a long-acting type of insulin that works slowly, over about 24 hours. Insulin is one of many hormones that help the body turn the food we eat into energy. This is done by using the glucose (sugar) in the blood as quick energy. Also, insulin helps us store energy that we can use later. When you have diabetes mellitus, your body cannot make enough insulin or does not use insulin properly. This causes you to have too much sugar in your blood. Like other types of insulin, insulin degludec is used to keep your blood sugar level close to normal. Liraglutide is to be used when diet and exercise do not result in good blood sugar control. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Appropriate studies have not been performed on the relationship of age to the effects of Xultophy in the pediatric population. Safety and efficacy have not been established. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Xultophy in the elderly. However, elderly patients a Continue reading >>

Insulin Degludec/liraglutide (by Injection)

Insulin Degludec/liraglutide (by Injection)

Insulin Degludec/Liraglutide (By injection) Insulin degludec and liraglutide combination is used to treat a type of diabetes mellitus ( sugar diabetes) called type 2 diabetes . Insulin degludec is a long-acting type of insulin that works slowly, over about 24 hours. Insulin is one of many hormones that help the body turn the food we eat into energy. This is done by using the glucose ( sugar ) in the blood as quick energy. Also, insulin helps us store energy that we can use later. When you have diabetes mellitus , your body cannot make enough insulin or does not use insulin properly. This causes you to have too much sugar in your blood. Like other types of insulin, insulin degludec is used to keep your blood sugar level close to normal. Liraglutide is to be used when diet and exercise do not result in good blood sugar control. This medicine is available only with your doctor's prescription. Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under the skin of your stomach , thighs, or upper arms . If you use other type of insulin in addition to this medicine, do not mix them into the same syringe. You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection . Do not use more medicine or use it more often than your doctor tells you to. You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. Use a new needle and syringe each time you inject your medicine. Never share medicine pens with others under any circumstances. Sharing needles or pens can result in transmission of infection . Drink extra fl Continue reading >>

More in diabetes