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Hypothesis Of Diabetes Mellitus

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Testing The Accelerator Hypothesis

The relationship between body mass and age at diagnosis of type 1 diabetes Abstract OBJECTIVE—Previous reports have predicted greater risk of type 1 diabetes among people who were heavier as young children. The Accelerator Hypothesis predicts earlier onset in heavier people, without necessarily a change in risk, and views type 1 and type 2 diabetes as the same disorder of insulin resistance, set against different genetic backgrounds. Insulin resistance is a function of fat mass, and increasing body weight in the industrialized world has been accompanied by earlier presentation (i.e., acceleration) of type 2 diabetes. We wanted to establish whether increasing body weight was also asociated with the earlier presentation of type 1 diabetes, as the Accelerator Hypothesis would predict. RESEARCH DESIGN AND METHODS— The relationships between fatness and age at diagnosis were examined in context of birth weight, weight change since birth, weight at diagnosis, BMI at diagnosis, and BMI 12 months later in 94 children aged 1–16 years (49 boys and 45 girls) presenting for management of acute-onset type 1 diabetes. RESULTS—BMI standard deviation score (SDS) at diagnosis, weight SDS cha Continue reading >>

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Popular Questions

  1. Sweet Debbie

    Is There a Difference Between Being Diabetic vs. Hyperglycemic?!!!

    Hi All,
    I just met my new doctor today. My old one is leaving the area and referred me to this one. She seems nice and told me she believes less is better (regarding meds) and is more into preventative care. The appointment went fairly well and she may be who I stick with, but now I'm not so sure?
    Anyway, she saw I was diabetic, but not on meds, & I replied that most of my a1c's have been in the 5's. So she then replied that I must not be diabetic then. She said something about changing my diagnosis from diabetic to hyperglycemic. But when I told her about my O.G.T.T. results (staying around 220) and my recent pizza incident (up to 260 at one hour and 235 at two hours), then she wavered some. I still don't know if she changed it or not. But as I left, I thought....wait a minute, what is the difference between being a diabetic and being hyperglycemic?!!!!
    Any takers on this one?
    Thanks,
    Debbie

  2. Lynnw

    They seem like the same thing to me. Maybe to her hyperglycemic mean 'pre-diabetic'?

  3. jwags

    I've never heard of a diagnosis of hypergycemic, either. I have heard of insulin resistant, glucose intolerant and pre diabetic. To me they are all the same. Once your pancreas starts to become dysfunctional your bg control goes crazy. The problem with these other labels is often doctors don't intervene until your bgs are already way high. My HbA1c was almost 11 when I was dx'd and it took forever to get it into the 5's. Now that I am close to normal I am still considered diabetic.

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