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Hypoglycemia Metformin

Just Been Told Reactive Hypoglycemia

Just Been Told Reactive Hypoglycemia

Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community Hodge1960 Reactive hypoglycemia Well-Known Member Hi, I have been told today that I will be taking Metformin for reactive hypoglycemia. I may sound crazy but this is a bit of a shock Don't worry, there are a few of us here with RH, and we have our own sub-board on the forum, So have a read, and ask anything you like. It IS a shock, but almost all of us have found that diet is the key, and most of us manage extremely well, virtually eliminating our hypos, and eating WELL, so please, come and join us. Hi, I have been told today that I will be taking Metformin for reactive hypoglycemia. I may sound crazy but this is a bit of a shock Hi, as Brun says have a look around and learn how to control RH! If you can understand what is happening, then you can get your head around how your life will improve with just dietary changes. I would also question the need for metformin. As my endocrinologist and doctor immediately stopped them because of the hypos. Have you an endocrinologist, if not have you been referred? It's important to get specialist help, even though we will help you. Ask away, it's good to have you in our unique club Hodge1960 Reactive hypoglycemia Well-Known Member i saw the Endocrinologist at the hospital , it was he who said i should take the Metformin... thanks for your kind words. |I will try not to be a pest with questions, thanks for the links too.x I want you to become a pest, because that way you can learn how to control your RH. The only stupid question is the one not asked. Kaz261 Reactive hypoglycemia Well-Known Member i saw the Endocrinologist at the hospital , it was he who said i should take the Metformin... thanks for your kind word Continue reading >>

Metformin. What Do You Need To Know?

Metformin. What Do You Need To Know?

What is type 2 diabetes? People with diabetes are not able to make enough insulin and/or respond normally to the insulin their body does make. When this happens, sugar (glucose) builds up in the blood. This can lead to serious medical problems including kidney damage, amputations and blindness. Diabetes is also closely linked to heart disease. The main goal of treating diabetes is to lower the level of your blood sugar as close to normal as possible. How is type 2 diabetes usually controlled? High blood sugar can be lowered by diet and exercise, by a number of oral medications and by insulin injections. Before taking biguanidas (metformin hydrochloride tablets) you should first try to control your diabetes by exercise and weight loss. Even if you are taking biguanidas, you should still exercise and follow the diet recommended for your diabetes. Does Metformin work differently from other glucose-control medications? Yes it does. Until Metformin was introduced, al¡ the available oral glucose-control medications were from the same chemical group called sulfonylureas. These drugs lower blood sugar primarily by causing more of the body's own insulin to be released. Metformin lowers the amount of sugar in your blood by helping your body respond better to its own insulin. Metformin (metformin hydrochloride tablets) does not cause your body to produce more insulin. Therefore, Metformin rarely causes hypoglycemia (low blood sugar) and it doesn't usually cause weight gain. What happens if my blood sugar is still too high? When blood sugar cannot be lowered enough by either Metformin or a sulfonylurea, the two medications may be effective taken together. However, if you are unable to maintain your blood sugar with diet, exercise and glucose-control medication taken orally, then y Continue reading >>

Fortamet Side Effects Center

Fortamet Side Effects Center

Fortamet (metformin hydrochloride) is an oral diabetes medicine for people with type 2 (non-insulin-dependent) diabetes. Metformin is sometimes used in combination with insulin or other medications, but it is not for treating type 1 diabetes. Fortamet is available in generic form. Common side effects of Fortamet include headache, muscle pain, nausea, vomiting, stomach upset or pain, diarrhea, gas, weakness, or a metallic taste in the mouth. Fortamet does not usually cause low blood sugar (hypoglycemia). Low blood sugar may occur if Fortamet is prescribed with other anti-diabetic medications. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. Tell your doctor if you experience serious side effects of Fortamet including shortness of breath, swelling or rapid weight gain, fever, body aches, or flu symptoms. Fortamet should be taken once daily. Dosage is individualized based on effectiveness and tolerance. The maximum recommended daily dose is 2500 mg. Hyperglycemia (high blood sugar) may result if you take Fortamet with drugs that raise blood sugar, such as: isoniazid, diuretics (water pills), steroids, phenothiazines, thyroid medicine, birth control pills and other hormones, seizure medicines, and diet pills, or medicines to treat asthma, colds or allergies. Hypoglycemia (low blood sugar) may result if you take Fortamet with drugs that lower blood sugar, such as: alcohol, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), beta-blockers, or probenecid. It may also interact with furosemide, nifedipine, cimetidine or ranitidine, amiloride or triamterene, digoxin, morphine, procainamide, quinidine, trimethoprim, or Continue reading >>

Metformin Causing Hypoglycemia?

Metformin Causing Hypoglycemia?

Registration is fast, simple and absolutely free so please,join our community todayto contribute and support the site. This topic is now archived and is closed to further replies. I don't actually have diabetes... I have insulin resistance due to PCOS....but I figured the people here would know a good deal about drugs such as metformin. I was pretty lucky with metformin at the start, the only side effects I had was periods of weakness/shakiness. Which I'm starting to wonder if it's because my blood sugar is dropping too low. Just tonight, my heart started pounding, my hands were shaking, my mind was racing, I got chills and hot flashes, I felt weak and my head started hurting. This happened about 4hrs after taking a dose of metformin. I had eaten about 5 hours prior. Most of those effects are gone now except my head still hurts a little and I still feel weak. I never had these little spells prior to metformin, but now they happen on a daily basis, usually in the evening. I do not have a glucose meter, so I can't test it. I go back to see my doctor next week anyway. I'm afraid to mention it to him because I don't want to be taken off metformin and my insulin resistance progress into type II diabetes or anything like that. No, I don't have a meter. Prior to this, my blood glucose has always been fine. It's never been high, though I do remember it being tested once when I was in the hospital and it was 70. My mother has type 1 diabetes and my grandmothers on both sides of my family had type II - and my brother is prediabetic if not full diabetic by now, so doctors do tend to check a lot because of my family history and because I am overweight (probably due to PCOS and hypothyroidism, or possibly because I eat junk LOL). Another thing I've been wondering....should I be mod Continue reading >>

Metformin, Sulfonylureas, Or Other Antidiabetes Drugs And The Risk Of Lactic Acidosis Or Hypoglycemia

Metformin, Sulfonylureas, Or Other Antidiabetes Drugs And The Risk Of Lactic Acidosis Or Hypoglycemia

A nested case-control analysis Abstract OBJECTIVE—Lactic acidosis has been associated with use of metformin. Hypoglycemia is a major concern using sulfonylureas. The aim of this study was to compare the risk of lactic acidosis and hypoglycemia among patients with type 2 diabetes using oral antidiabetes drugs. RESEARCH DESIGN AND METHODS—This study is a nested case-control analysis using the U.K.-based General Practice Research Database to identify patients with type 2 diabetes who used oral antidiabetes drugs. Within the study population, all incident cases of lactic acidosis and hypoglycemia were identified, and hypoglycemia case subjects were matched to up to four control patients based on age, sex, practice, and calendar time. RESULTS—Among the study population of 50,048 type 2 diabetic subjects, six cases of lactic acidosis during current use of oral antidiabetes drugs were identified, yielding a crude incidence rate of 3.3 cases per 100,000 person-years among metformin users and 4.8 cases per 100,000 person-years among users of sulfonylureas. Relevant comorbidities known as risk factors for lactic acidosis could be identified in all case subjects. A total of 2,025 case subjects with hypoglycemia and 7,278 matched control subjects were identified. Use of sulfonylureas was associated with a materially elevated risk of hypoglycemia. The adjusted odds ratio for current use of sulfonylureas was 2.79 (95% CI 2.23–3.50) compared with current metformin use. CONCLUSIONS—Lactic acidosis during current use of oral antidiabetes drugs was very rare and was associated with concurrent comorbidity. Hypoglycemic episodes were substantially more common among sulfonylurea users than among users of metformin. Metformin plays a pivotal role in the treatment of patients with t Continue reading >>

Metformin, Sulfonylureas, Or Other Antidiabetes Drugs And The Risk Of Lactic Acidosis Or Hypoglycemia

Metformin, Sulfonylureas, Or Other Antidiabetes Drugs And The Risk Of Lactic Acidosis Or Hypoglycemia

Metformin, Sulfonylureas, or Other Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia 3Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts 4Department of Epidemiology, School of Public Health, Boston University, Massachusetts 3Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts 4Department of Epidemiology, School of Public Health, Boston University, Massachusetts 5Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland 1Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland 2Division of Endocrinology, Diabetes, and Clinical Nutrition, University Hospital Basel, Basel, Switzerland 3Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts 4Department of Epidemiology, School of Public Health, Boston University, Massachusetts 5Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland Corresponding author: Christoph R. Meier, hc.sbhu@hcreiem Received 2008 Jun 27; Accepted 2008 Aug 10. Copyright 2008, American Diabetes Association Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See for details. This article has been cited by other articles in PMC. OBJECTIVELactic acidosis has been associated with use of metformin. Hypoglycemia is a major concern using sulfonylureas. The aim of this study was to compare the risk of lactic acidosis and hypoglycemia among patients with type 2 diabetes using oral antidiabetes drugs. RESEAR Continue reading >>

Metformin? | Dailystrength

Metformin? | Dailystrength

Metformin will do the opposite of what you want it to. It increases insulin production and is used for type 2 diabetes. I was on diazoxide when I was in elementary school and it was harder for me to eat at certain times. I'm considering going back on it. Here's the information on it: Ask your doctor. it might not be right for you, but I doubt metformin is either...Hope this helps Don't do it!!! Two doctors made me do this although I have low blood sugar and I now have shaky hands, nerve damage, and my hypoglycemia is worse than ever! Get another opinion. I am not on any medication now and can handle it pretty well eating a low-glycemia index diet. If you google "low GI foods," you can find lists of foods. These foods take longer to dissolve in your blood stream, making the amounts of time between snacks/meals longer. Trust me, it has been a horrible 2 years but I am now doing so much better! Yes, agree with above poster. I should've added that I was only on medication for about 2 years, and then we realized I can manage with low GI foods/complex carbs/balancing carbs, protein, fat intake with exercise. Try the food first!!! I have tons of info on hypo eating, if you want it. Most of us aren't on medicine. I am so sorry it has taken me so long to get back. I have been trying and trying to avoid it. It got to the point where I feel drunk after everything I eat, even if it's only a salad. This is the most horrible thing I have ever had to endure. Between the blood sugar issues and hashimotos I am just so tired of the fight. I started on Metformin and it helps make the drunk feeling go away. The doc said it will help the insulin get into my cells and will help me lose weight and then once I do that I can get back off the med. I exercise faithfully, daily. But the Continue reading >>

Metformin And Hypoglycemia

Metformin And Hypoglycemia

so today i finally had a doc do something I didn't expect. He actually listened to me about being hypo instead of telling me there is now way i could get that. I am not diabetic but because i deal with hypo does Metformin create that as a side effect? any info you have on how this drug works would be much appreciated Georgia: Yes, I see that Metformin is used to regulate blood sugars, probably in T2's. What are you taking it for? I also saw something about using it for PCOS. I didn't read all the details. Maybe you're sensitive to it. It sounds logical to me if it's making you hypo!!! What else did the doctor say. You are your best doctor!!!! You live in your body - they don't. I've been precribed meds for certain things and I refuse to take them. Use your intuition. so today i finally had a doc do something I didn't expect. He actually listened to me about being hypo instead of telling me there is now way i could get that. I am not diabetic but because i deal with hypo does Metformin create that as a side effect? any info you have on how this drug works would be much appreciated Metformin is a well known drug that's been around for a long time. It does a couple of things. It helps with insulin resistance and it also regulates how much glucose the liver puts out in the morning, reducing dawn phenomenen. It can cause digestive problems especially at first. It is a considered to be very safe drug. I took it for about 6 months but it didn't help (or hurt) Last edited by itotito; 12-28-2009 at 04:25 PM. I just got the drug today but i read in it where hypo can be a side effect for some. that just makes me nervous to take it I just got the drug today but i read in it where hypo can be a side effect for some. that just makes me nervous to take it I would bet it reduces your Continue reading >>

Metformin Overdose-induced Hypoglycemia In The Absence Of Other Antidiabetic Drugs.

Metformin Overdose-induced Hypoglycemia In The Absence Of Other Antidiabetic Drugs.

Abstract CONTEXT: Lactic acidosis is a well-recognized consequence of metformin. Hypoglycemia has been reported previously in metformin overdose, but the presence of other co-ingestions (e.g., a sulfonylurea) was not definitively excluded. CASE DETAILS: A 15-year-old girl ingested 75 g of metformin and 3 g of quetiapine. On examination in the emergency department 2 h later, she was drowsy but had normal vital signs. She developed lactic acidosis, hypotension, and recurrent and severe hypoglycemia (15 mg/dL and 20 mg/dL), requiring boluses of 50%dextrose. The first episode of hypoglycemia occurred approximately 4 h after ingestion. Serum metformin level 2 h after ingestion was 267 mg/L (therapeutic range, 0.465-2.5), and serum insulin was 2 mU/L (normal range, 6-35). Extensive laboratory investigation using high-resolution mass-spectrometry ruled out other possible hypoglycemic agents. She recovered after hemodialysis. DISCUSSION: Metformin overdose can cause severe hypoglycemia in the absence of other antidiabetic drugs. Potential mechanisms of metformin-induced hypoglycemia include decreased hepatic glucose production, decreased glucose absorption, and poor oral intake. Continue reading >>

Hypoglycemia Induced By Therapeutic Doses Of Metformin In The Absence Of Other Anti-diabetic Drugs

Hypoglycemia Induced By Therapeutic Doses Of Metformin In The Absence Of Other Anti-diabetic Drugs

Abstract Context: Hypoglycemia due to metformin used in therapeutic dose is not frequently encountered. Metformin induced hypoglycemia has been linked previously to metformin overdose, but the presence of other co-ingestions (e.g., a sulfonylurea) was not definitively excluded. Case details: A 64-year-old male ingested 750 mg of metformin. On examination in the emergency department 8 h later, he was drowsy; nevertheless he had normal vital signs. He developed severe hypoglycemia (21 mg/dL), requiring a bolus of 50%dextrose followed by resumption of oral intake. This episode of hypoglycemia occurred approximately 8 h after ingestion. Discussion: Metformin ingestion in therapeutic doses can cause hypoglycemia in the absence of other glucose-lowering drugs, there for blood glucose levels should be monitored closely. Mechanisms via which metformin can induce hypoglycemia include reduction in hepatic glucose production, decreased glucose absorption, and poor oral intake. Discover the world's research 14+ million members 100+ million publications 700k+ research projects Join for free Context: Hypoglycemia due to metformin used in therapeutic dose is not frequently encountered. Metformin induced hypoglycemia has been linked previously to metformin overdose, but the presence of other co-ingestions (e.g., a sulfonylurea) was not definitively excluded. Case details: A 64-year-old male ingested 750 mg of metformin. On examination in the emergency department 8 h later, he was drowsy; nevertheless he had normal vital signs. He developed severe hypoglycemia (21 mg/dL), requiring a bolus of 50%dextrose followed by resumption of oral intake. This episode of hypoglycemia occurred approximately 8 h after ingestion. Discussion: Metformin ingestion in therapeutic doses can cause hypoglycem Continue reading >>

Metformin And Type 2 Diabetes Mellitus

Metformin And Type 2 Diabetes Mellitus

Each of the following statements about metformin as a treatment for type 2 diabetes mellitus is true except: It lowers hemoglobin AIc concentrations by 1.0% to 1.5%. It is not associated with weight gain. When metformin is used as monotherapy, hypoglycemia is a serious side effect. It has been shown to reduce all-cause mortality. Source: Cheng AY, Fantus IG. Oral antihyperglycemic therapy for type 2 diabetes mellitus. CMAJ 2005;172:213-26. This question is based on Question 32, Metformin and type 2 diabetes mellitus. Self Learning 2005;20(4):38-9. Published 6 times yearly, each issue of Self Learning contains a blend of questions from a range of peer-reviewed medical journals. College of Family Physicians of Canada members who subscribe to the Self Learning program may claim up to 5 Mainpro-M1 credits for each completed issue and up to 30 Mainpro-M1 credits for each year in which they subscribe. For further information please visit the College of Family Physicians of Canada website, which includes information on free trials of the on-line program, at Go to: The incorrect statement is: 3. When metformin is used as monotherapy, hypoglycemia is a serious side effect. Metformin lowers blood glucose among patients with type 2 diabetes mellitus largely by decreasing hepatic glucose output. It is also thought to increase glucose uptake by skeletal muscle. It is not protein bound and has maximum accumulation in the small intestine wall. It is excreted unmodified by the kidney. In placebo-controlled trials, metformin lowered hemoglobin AIc concentrations by 1.0% to 1.5%. The efficacy of metformin monotherapy is equivalent to that of sulfonylurea monotherapy. It is associated with weight loss or at least no weight gain. Improvements in lipid profiles have also been noted. The Uni Continue reading >>

Metformin (oral Route)

Metformin (oral Route)

Precautions Drug information provided by: Micromedex It is very important that your doctor check your progress at regular visits, especially during the first few weeks that you take this medicine. Blood and urine tests may be needed to check for unwanted effects. This medicine may interact with the dye used for an X-ray or CT scan. Your doctor should advise you to stop taking it before you have any medical exams or diagnostic tests that might cause less urine output than usual. You may be advised to start taking the medicine again 48 hours after the exams or tests if your kidney function is tested and found to be normal. Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests. It is very important to carefully follow any instructions from your health care team about: Alcohol—Drinking alcohol may cause severe low blood sugar. Discuss this with your health care team. Other medicines—Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems. Counseling—Other family members need to learn how to prevent side effects or help with side effects if they occur. Also, patients with diabetes may need special counseling about diabetes medicine dosing changes that might occur with lifestyle changes, such as changes in exercise or diet. Counseling on birth control and pregnancy may be needed because of the problems that can occur in pregnancy for patients with diabetes. Travel—Keep a recent prescription and your medical history with you. Be prepared for an emergency as you would norm Continue reading >>

Can You Have Low Blood Sugar With Type 2 Diabetes?

Can You Have Low Blood Sugar With Type 2 Diabetes?

back to Overview Know-how Type 2 A tag-team approach on low blood sugar with type 2 diabetes. Markus recently wrote an article on our German language blog talking about low blood sugar with type 2 diabetes. The question (“can I have low blood sugar with type 2 diabetes?”) is very common, and it’s easy to see why it’s of concern. So I’ve helped Markus bring his German post to life here in English. I hope it helps! Here’s Markus: Low blood sugar In 2014, results from the DAWN2 study were announced. It was the largest study of its kind (15,000 participants) on the “fears & needs of people with diabetes and their families.” One result stood out: The gravest fears are related to low blood sugars, especially at night. Up to 69% of the participants share this fear! So! Can you have low blood sugar with type 2 diabetes? Yes! Of course! But let’s think about who exactly is at risk – and why. It’s common to think: Type 1 diabetes = at risk for lows Type 2 diabetes = not at risk for lows But that isn’t correct at all, so we should wipe it from our mind. So… what do I need to know? Maybe it’s more accurate to say that people with type 2 diabetes who take certain types of medication are more at risk for lows. We’re getting closer! But to get to the truth, we should take a look at someone without diabetes. Is it possible for them to have lows, too? Theoretically yes, especially if doing long-lasting physical activities without proper food intake. Additionally, extreme stress and binge drinking are also common causes of low blood sugar for people without diabetes. However, it’s pretty rare because as soon as BG’s drop below 80 mg/dl (4.4 mmol/L), the natural counterregulatory system kicks in, raising blood sugar back to normal levels. I’ve never exp Continue reading >>

Oral Hypoglycemic Drugs

Oral Hypoglycemic Drugs

Oral hypoglycemic drugs are used only in the treatment of type 2 diabetes which is a disorder involving resistance to secreted insulin. Type 1 diabetes involves a lack of insulin and requires insulin for treatment. There are now four classes of hypoglycemic drugs: Sulfonylureas Metformin Thiazolidinediones Alpha-glucosidase inhibitors. These drugs are approved for use only in patients with type 2 diabetes and are used in patients who have not responded to diet, weight reduction, and exercise. They are not approved for the treatment of women who are pregnant with diabetes. SULFONYLUREAS – Sulfonylureas are the most widely used drugs for the treatment of type 2 diabetes and appear to function by stimulating insulin secretion. The net effect is increased responsiveness of ß-cells (insulin secreting cells located in the pancreas) to both glucose and non-glucose secretagogues, resulting in more insulin being released at all blood glucose concentrations. Sulfonylureas may also have extra-pancreatic effects, one of which is to increase tissue sensitivity to insulin, but the clinical importance of these effects is minimal. Pharmacokinetics – Sulfonylureas differ mainly in their potency & their duration of action. Glipizide, glyburide (glibenclamide), and glimepiride are so-called second-generation sulfonylureas. They have a potency that allows them to be given in much lower doses. Those drugs with longer half-lives (particularly chlorpropamide, glyburide, and glimepiride) can be given once daily. This benefit may be counterbalanced by a substantially increased risk of hypoglycemia. Side effects – Sulfonylureas are usually well tolerated. Hypoglycemia is the most common side effect and is more common with long-acting sulfonylureas. Patients recently discharged from hospit Continue reading >>

Side Effects Of Metformin: What You Should Know

Side Effects Of Metformin: What You Should Know

Metformin is a prescription drug used to treat type 2 diabetes. It belongs to a class of medications called biguanides. People with type 2 diabetes have blood sugar (glucose) levels that rise higher than normal. Metformin doesn’t cure diabetes. Instead, it helps lower your blood sugar levels to a safe range. Metformin needs to be taken long-term. This may make you wonder what side effects it can cause. Metformin can cause mild and serious side effects, which are the same in men and women. Here’s what you need to know about these side effects and when you should call your doctor. Find out: Can metformin be used to treat type 1 diabetes? » Metformin causes some common side effects. These can occur when you first start taking metformin, but usually go away over time. Tell your doctor if any of these symptoms are severe or cause a problem for you. The more common side effects of metformin include: heartburn stomach pain nausea or vomiting bloating gas diarrhea constipation weight loss headache unpleasant metallic taste in mouth Lactic acidosis The most serious side effect metformin can cause is lactic acidosis. In fact, metformin has a boxed warning about this risk. A boxed warning is the most severe warning from the Food and Drug Administration (FDA). Lactic acidosis is a rare but serious problem that can occur due to a buildup of metformin in your body. It’s a medical emergency that must be treated right away in the hospital. See Precautions for factors that raise your risk of lactic acidosis. Call your doctor right away if you have any of the following symptoms of lactic acidosis. If you have trouble breathing, call 911 right away or go to the nearest emergency room. extreme tiredness weakness decreased appetite nausea vomiting trouble breathing dizziness lighthea Continue reading >>

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