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Humulin U 500 Side Effects

What Are The Possible Side Effects Of Concentrated Insulin (humulin R (concentrated))?

What Are The Possible Side Effects Of Concentrated Insulin (humulin R (concentrated))?

A A A Medications and Drugs Brand Names: Humulin R (Concentrated) Generic Name: insulin regular, concentrated (U-500) (Pronunciation: IN soo lin) What is the most important information I should know about concentrated insulin (Humulin R (Concentrated))? What should I discuss with my healthcare provider before using concentrated insulin (Humulin R (Concentrated))? What is concentrated insulin (Humulin R (Concentrated))? Concentrated insulin is a man-made form of a hormone that is produced in the body. It works by lowering levels of glucose (sugar) in the blood. Concentrated insulin (U-500) is a long-acting form of insulin that is different from other forms that are made from animal insulin. Concentrated insulin is used to treat type 1 (insulin-dependent) diabetes in people with significant daily insulin needs (more than 200 units per day). Concentrated insulin may also be used for purposes other than those listed in this medication guide. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tell your doctor if you have any pain, redness, swelling, or skin changes where the insulin was injected. Low blood sugar is the most common side effect of concentrated insulin. Symptoms of low blood sugar may include headache, nausea, hunger, confusion, drowsiness, weakness, dizziness, blurred vision, fast heartbeat, sweating, tremor, trouble concentrating, confusion, seizure (convulsions), or death. Watch for signs of low blood sugar. This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088. What is the most important information I should know about concen Continue reading >>

Humulin R U-500 Pdr+ Consumer Monograph | Pdr.net

Humulin R U-500 Pdr+ Consumer Monograph | Pdr.net

What is this medication and its most common uses? Humulin R U-500 is a concentrated insulin that is used to control high blood sugar in people with diabetes mellitus who need more than 200 units of insulin in a day. What should I know when beginning and continuing on this medication? Your body needs insulin to turn sugar into energy. Diabetes develops when your body does not make enough insulin or does not properly use the insulin it makes. Humulin R U-500 may help control your blood sugar levels by allowing blood sugar to move from your bloodstream into your cells for energy. What are the beneficial effects of this medication and when should I begin to have results? What: Lowering your blood sugar to a normal level may prevent or delay potential complications associated with diabetes, such as blindness, kidney failure, or heart problems. When: Humulin R U-500 may start working within 30 minutes after you inject it. Check your blood sugar regularly and as your healthcare provider tells you to. Your healthcare provider will also do regular blood tests to measure your blood sugar levels and your hemoglobin A1C (measures your average blood sugar levels over a 2- to 3-month period). Stay on your prescribed diet and exercise program, as this will also affect the results of your blood tests. What are the possible side effects of this medication? The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication. More common side effects may include: low blood sugar, allergic reactions, reactions at the injection site, skin thickening at the injection site, itching, ras Continue reading >>

Humulin R U-500 Information, Side Effects, Warnings And Recalls

Humulin R U-500 Information, Side Effects, Warnings And Recalls

Humulin R U-500 is usually given two or three times daily before meals. The dosage and time of Humulin R U-500 should be individualized and determined, based on the physician's advice, in accordance with the needs of the patient. The injection of Humulin R U-500 should be followed by a meal within approximately 30 minutes of administration. The average range of total daily insulin requirement for maintenance therapy in insulin-treated patients without severe insulin resistance lies between 0.5 and 1.0 unit/kg/day. However, in pre-pubertal children it usually varies from 0.7 to 1.0 unit/kg/day, but can be much lower during the period of partial remission. In situations of insulin resistance, e.g., during puberty or due to obesity, the daily insulin requirement may be substantially higher. Initial dosages for type 2 diabetes patients are often lower, e.g., 0.2 to 0.4 units/kg/day. Humulin R U-500 is useful for the treatment of insulin resistant patients with diabetes requiring daily doses of more than 200 units, since a large dose may be administered subcutaneously in a reasonable volume. Humulin R U-500 may be administered by subcutaneous injection in the abdominal wall, the thigh, the gluteal region or in the upper arm. Subcutaneous injection into the abdominal wall ensures a faster absorption than from other injection sites. Injection into a lifted skin fold minimizes the risk of intramuscular injection. Injection sites should be rotated within the same region. As with all insulin, the duration of action will vary according to the dose, injection site, blood flow, temperature, and level of physical activity. Humulin R U-500 should only be administered subcutaneously. Do not administer Humulin R U-500 intravenously or intramuscularly. Parenteral drug products should be Continue reading >>

Humulin R U-500

Humulin R U-500

Generic Name: insulin human Dosage Form: injection, solution Indications and Usage for Humulin R U-500 HUMULIN R U-500 is a concentrated human insulin indicated to improve glycemic control in adult and pediatric patients with diabetes mellitus requiring more than 200 units of insulin per day. Limitation of Use The safety and efficacy of HUMULIN R U-500 used in combination with other insulins has not been determined. The safety and efficacy of HUMULIN R U-500 delivered by continuous subcutaneous infusion has not been determined. Humulin R U-500 Dosage and Administration Important Administration Instructions Prescribe HUMULIN R U-500 ONLY to patients who require more than 200 units of insulin per day. Humulin R U-500 is available as a KwikPen or multiple dose vial. Patients using the vial must be prescribed the U-500 insulin syringe to avoid medication errors. Instruct patients using the vial presentation to use only a U-500 insulin syringe and on how to correctly draw the prescribed dose of HUMULIN R U-500 into the U-500 insulin syringe. Confirm that the patient has understood these instructions and can correctly draw the prescribed dose of HUMULIN R U-500 with their syringe [see Dosage and Administration (2.4) and Warnings and Precautions (5.1)]. Advise the patient to read the FDA-approved patient labeling (Patient Information and Instructions for Use). Train patients on proper use and injection technique before initiating HUMULIN R U-500. Training reduces the risk of administration errors such as needle sticks and dosing errors. Instruct patients to always check the insulin label before administration to confirm the correct insulin product is being used [see Warnings and Precautions (5.1)]. Inspect HUMULIN R U-500 visually for particulate matter and discoloration. Only Continue reading >>

Humulin U-500: Counseling Your Patients

Humulin U-500: Counseling Your Patients

Pharmacists looking to counsel patients on Humulin R U-500 can use counseling points that are very similar to U-100, which patients often find comforting. To begin with the product, which is a concentrated insulin that is typically considered in patients injecting large volumes of U-100, should be clear and colorless at all times. They should be administering the insulin 30 minutes before their meal(s). The most common adverse effect reported with Humulin R U-500 is hypoglycemia. Studies show that patients are at risk for severe hypoglycemia as long as 18-24 hours post injection and should always be considered a risk factor if the patient is found unresponsive. For this reason patients should also be cautious while driving/operating heavy machinery at all times, but especially when first starting this medication as well as any dose changes. To minimize the risk of hypoglycemia, Humulin R U-500 should not be administered IV, IM, or via insulin pump in a hospital setting or outpatient. Other common adverse effects would include lipodystrophy, weight gain, edema, allergic reactions, and/or immunogenicity (antibody formulation). Considered a Pregnancy Category B, this product, like other insulin products should be used in pregnant women with both caution and care but it is noteworthy that Humulin R U-500 does not pose any greater risk. The insulin does pass into the breast milk and gets ingested by the infant, however, the insulin is broken down into the gastrointestinal tract and does not raise any concern, therefore, it is safe to administer while breastfeeding. Commercially available as both a KwikPen and vials, the KwikPens are 3 mL and contain 1,500 units in each pen availablein packs of 2 and 3 pens, while the vials are available as 20 mL containing 10,000 units of i Continue reading >>

U.s. Food And Drug Administration Approves Humulin® R U-500 Kwikpen®

U.s. Food And Drug Administration Approves Humulin® R U-500 Kwikpen®

INDIANAPOLIS, Jan. 21, 2016 /PRNewswire/ -- The U.S. Food and Drug Administration (FDA) has approved Eli Lilly and Company's (NYSE: LLY) Humulin® R U-500 KwikPen®(insulin human injection) 500 units/mL, a pre-filled device containing Humulin R U-500, a highly concentrated formulation of insulin. Humulin R U-500 is the only FDA-approved insulin that is five-times more concentrated than standard U-100 insulin. This insulin is used to treat high blood sugar in people with type 1 and type 2 diabetes who need more than 200 units of insulin per day. The safety and efficacy of Humulin R U-500 used in combination with other insulins or delivered by an insulin infusion pump has not been determined. "People with diabetes and severe insulin resistance who have become poorly responsive to the effects of insulin may require much higher insulin doses – more than 200 units per day – to help keep their blood sugar levels on target," said Jeffrey A. Jackson, MD, FACE, CDE, Medical Fellow, US Medical Affairs, Lilly Diabetes. "For these patients, the U-500 KwikPen is now available as a convenient alternate option to deliver a large dose of insulin in a reasonable volume. It was specifically designed as a dedicated dosing device to eliminate the need for dose conversion, as compared to use of the vial and syringe options, which some people may find to be an improvement." Until now, Humulin R U-500 was only available in a vial, administered with either a U-100 insulin syringe or a volumetric (tuberculin) syringe that requires conversion to respective syringe "unit markings" or volume markings. Although each U-500 KwikPen holds 1500 units of insulin (the amount in five U-100 insulin pens), it is the same size as other KwikPens and dials in five-unit increments. The U-500 KwikPen has a u Continue reading >>

Humulin R U-500 (insulin) Injection: Uses, Dosage & Side Effects

Humulin R U-500 (insulin) Injection: Uses, Dosage & Side Effects

Humulin R U-500 is a drug which is used in the treatment of diabetic patients with marked insulin resistance (daily requirements more than 200 units). This drug is available as an injection suspension containing insulin human 500 units in 1 milliliter. You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist. This medication should be taken by mouth as instructed by your doctor. Do not crush or chew the drug because it may diminish its effects. This medication should be taken with a full glass of water unless your doctor tells you otherwise. You should swallow the drug whole. Your dosage is based on your medical condition and the way you will respond to treatment. Take this drug regularly to experience the most benefits. You should also take this drug at the same time each day. If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label. Continue reading >>

Fda Approves First U-500 Insulin Pen

Fda Approves First U-500 Insulin Pen

(Humulin(R) R U-500 KwikPen(R) (PRNewsFoto/Eli Lilly and Company)) On January 21, 2016, the U.S. Food and Drug Administration (FDA) approved the Humulin R U-500 KwikPen (insulin human injection) 500 units/ml for people with Type 1 and Type 2 diabetes who need more than 200 units of insulin per day. The device, which is manufactured by pharmaceutical company Eli Lilly and Company, is the first insulin pen to be approved for delivering U-500 insulin. U-500 insulin is five times as concentrated as standard U-100 insulin, and is generally used to treat people who have severe insulin resistance. Larger volumes of insulin are absorbed less predictably and therefore have less predictable effects on blood sugar levels. Because a dose of U-500 insulin takes only one-fifth the volume of the same dose of U-100 insulin, this variability is reduced. Until this approval, Humulin R U-500 has only been available in a vial, administered either through a U-100 or TB syringe and requiring conversion to the syringe unit markings. This new prefilled pen is specifically designed for U-500 insulin, potentially helping to prevent dosing errors. The device is the same size as other KwikPens (in an aqua color), but it dials in 5-unit increments and holds 1,500 units of insulin — the amount contained in five U-100 insulin pens. Unopened pens should be kept in the refrigerator, and in-use pens should be kept at room temperature. Once open, Humulin R U-500 KwikPens should be thrown out after 28 days, even if insulin remains. The pen is expected to hit the market in April 2016. According to Eli Lilly, “the Humulin R U-500 Savings Card Program offers eligible, commercially insured patients the opportunity to pay as little as $25 per prescription for up to 12 redemptions over a 12-month period.” Continue reading >>

Humulin R

Humulin R

Humulin R (insulin (human recombinant)) is a hormone that is produced in the body used to treat diabetes. Common side effects of Humulin R include: injection site reactions (e.g., pain, redness, irritation). Low blood sugar (hypoglycemia) is the most common side effect of Humulin R. Symptoms of low blood sugar include headache, hunger, weakness, sweating, tremors, irritability, trouble concentrating, rapid breathing, fast heartbeat, fainting, or seizure (severe hypoglycemia can be fatal). Tell your doctor if you have serious side effects of Humulin R including: signs of low potassium level in the blood (such as muscle cramps, weakness, irregular heartbeat). Each patient's diabetes is different, and the injection schedule and use of Humulin R is individualized. A doctor determines which insulin to use, how much, and when and how often to inject it. Humulin R may interact with albuterol, clonidine, reserpine, guanethidine, or beta-blockers. Tell your doctor all medications you are taking. Tell your doctor if you are pregnant before using Humulin R. If you are planning pregnancy, discuss a plan for managing your blood sugars with your doctor before you become pregnant. Your doctor may switch the type of insulin you use during pregnancy. This medication does not pass into breast milk. Consult your doctor before breastfeeding. Insulin needs may change while breastfeeding. Our Humulin R (insulin (human recombinant)) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Continue reading >>

Humulin R U-500 (concentrated) Side Effects

Humulin R U-500 (concentrated) Side Effects

Applies to insulin regular: injectable solution, subcutaneous solution Frequency not reported: Transitory, reversible ophthalmologic refraction disorder, worsening diabetic neuropathy[ Ref ] Transitory, reversible ophthalmologic refraction disorder and worsening of diabetic retinopathy has been reported with insulin initiation and glucose control intensification. Over the long-term, improved glycemic control decreases the risk for diabetic neuropathy.[ Ref ] Uncommon (0.1% to 1%): Lipodystrophy[ Ref ] Long-term use of insulin can cause lipodystrophy at the site of repeated insulin injections. Lipodystrophy includes lipohypertrophy (thickening of adipose tissue) and lipoatrophy (thinning of adipose tissues).[ Ref ] Uncommon (0.1% to 1%): Local reactions such as redness, swelling, or itching at the injection site Very rare (less than 0.01%): Anaphylactic reactions[ Ref ] Hypersensitivity reactions have included both local and systemic reactions. Anaphylaxis has been reported. Local reactions have presented as erythema , local edema , and pruritus at the injection site. Most minor reactions to insulin at the injection site resolve in a few days to a few weeks. In some instances these reactions have been caused by other factors such as irritants in a skin cleansing agent or poor injection technique. Localized reactions have been reported with metacresol, which is an excipient in many insulin products. Generalized allergy to insulin may present as a whole body rash, dyspnea , wheezing , hypotension , tachycardia , or diaphoresis.[ Ref ] Increases in titers of anti-insulin antibodies that react with human insulin have been observed; some data indicates the increase is transient. The clinical significance of these antibodies is unknown; it does not appear to cause deteriorati Continue reading >>

Insulin Regular, Concentrated (u-500)

Insulin Regular, Concentrated (u-500)

Brand: HumuLIN R (Concentrated), HumuLIN R KwikPen (Concentrated) What is the most important information I should know about U-500 insulin? Never share an injection pen, cartridge, or syringe with another person, even if the needle has been changed. Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Concentrated (U-500) insulin is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. U-500 insulin is five times more concentrated than regular U-100 insulin. U-500 insulin is used to improve blood sugar control in adults and children with diabetes mellitus who have significant daily insulin needs (more than 200 units per day). U-500 insulin may also be used for purposes not listed in this medication guide. What should I discuss with my healthcare provider before using U-500 insulin? You should not use this medicine if you are allergic to insulin, or if you are having an episode of hypoglycemia (low blood sugar). To make sure U-500 insulin is safe for you, tell your doctor if you have: low levels of potassium in your blood (hypokalemia). Tell your doctor if you also take pioglitazone or rosiglitazone (sometimes contained in combinations with glimepiride or metformin). Taking certain oral diabetes medicines while you are using insulin may increase your risk of serious heart problems. Follow your doctor's instructions about using insulin if you are pregnant or breast-feeding a baby. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester of pregnancy. Your dose needs may also be different while you are breast-feeding. U-500 insulin is concentrated and contains 500 units of insulin in each milliliter (mL). This is five times more Continue reading >>

Important Safety Information For Humulin R U-500

Important Safety Information For Humulin R U-500

If you have liver, kidney, or heart problems or any other medical conditions. If you are pregnant, plan to become pregnant, or are breast-feeding. About all the medicines you take, including prescription (especially ones commonly called TZDs [thiazolidinediones]) and over the counter medicines, vitamins, and herbal supplements. Before you start using Humulin R U-500, talk to your healthcare provider about low blood sugar and how to manage it. Read the detailed Instructions for Use that come with your Humulin R U-500. Take Humulin R U-500 exactly as your healthcare provider tells you to. Your healthcare provider should show you how much Humulin R U-500 to use and when to use it. Know the dose of Humulin R U-500 you use. Do not change your dose unless your healthcare provider tells you to. Check your insulin label each time you give your injection to make sure you are using the correct insulin. Humulin R U-500 KwikPen: The U-500 KwikPen is specially made to dial and deliver doses of Humulin R U-500 insulin. Do not use any syringe to remove Humulin R U-500 insulin from your U-500 KwikPen. The markings on certain syringes will not measure your dose correctly. A severe overdose can happen, causing low blood sugar, which may put your life in danger. Humulin R U-500 vial: There is a special U-500 insulin syringe to measure Humulin R U-500. Use only a U-500 insulin syringe to draw up and inject your Humulin R U-500. If you do not use the right syringe type, you may take the wrong dose of Humulin R U-500. This can cause you to have too low blood sugar (hypoglycemia) or too high blood sugar (hyperglycemia). Your healthcare provider should show you how to draw up Humulin R U-500. Use Humulin R U-500 30 minutes before eating a meal. Inject Humulin R U-500 under your skin (subcutan Continue reading >>

Humulin R Concentrate For Solution For Injection 500u Drug Medication Dosage Information

Humulin R Concentrate For Solution For Injection 500u Drug Medication Dosage Information

*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different. Class B - Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women. OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester. Class B - Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women. OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester. Class B - Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women. OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester. Continue reading >>

What Is Humulin R (insulin Regular)?

What Is Humulin R (insulin Regular)?

Humulin R is the brand name of a medicine that contains insulin regular (a short-acting form of insulin). Insulin is a hormone that's produced by the body in the pancreas. It works to lower levels of sugar in the blood. This prescription medicine is injected to improve blood sugar control in adults with diabetes. The U.S. Food and Drug Administration (FDA) first approved human insulin in 1982. Humulin R is marketed by Ely Lilly and Company. Humulin R Warnings Humulin R shouldn't be used during an episode of hypoglycemia (low blood sugar). Low blood sugar is a common side effect of insulin. Symptoms may include: Hunger Headache Weakness Sweating Irritability Tremors Trouble concentrating Fast heartbeat Fainting Seizures Look out for signs of low blood sugar, and carry candy or glucose tablets in case you have an episode. You may also experience signs of hyperglycemia (high blood sugar), which often include: Hunger Increased thirst Dry mouth Fruity breath odor Dry skin Blurred vision Weight loss Increased urination Drowsiness You'll need to monitor your blood sugar levels often while taking this medicine. It's important that you keep Humulin R with you at all times. Be sure to get your prescription refilled before you run out of this medicine. Don't change the brand of insulin or type of syringe you're using without first talking to your healthcare provider. They may not be interchangeable. Before taking Humulin R, tell your doctor if you have, or have ever had: Kidney or liver disease Heart failure, or other heart problems Nerve, adrenal, pituitary, or thyroid problems Eye problems caused by diabetes Allergies to medications Let your doctor know about all the medicines you're taking while using Humulin R, especially certain oral diabetes drugs, such as Actos (pioglitazon Continue reading >>

Insulin Human Regular (injection Route)

Insulin Human Regular (injection Route)

Insulin human regular is a short-acting type of insulin. Insulin is one of many hormones that help the body turn the food we eat into energy. This is done by using the glucose (sugar) in the blood as quick energy. Also, insulin helps us store energy that we can use later. When you have diabetes mellitus, your body cannot make enough insulin or does not use insulin properly. This causes you to have too much sugar in your blood. Like other types of insulin, insulin human regular is used to keep your blood sugar level close to normal. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Appropriate studies have not been performed on the relationship of age to the effects of insulin human regular in the pediatric population. Safety and efficacy have not been established. Although appropriate studies on the relationship of age to the effects of insulin human regular have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of this medicine in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems which may require an adjustment in the dose in patients receiving t Continue reading >>

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