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Humulin-r Regular U-500 | Definition Of Humulin-r Regular U-500 By Medical Dictionary

Humulin-r Regular U-500 | Definition Of Humulin-r Regular U-500 By Medical Dictionary

Humulin-R Regular U-500 | definition of Humulin-R Regular U-500 by Medical dictionary Also found in: Dictionary , Thesaurus , Encyclopedia . 1. the major fuel-regulating hormone of the body, a double-chain protein formed from proinsulin in the beta cells of the islets of Langerhans in the pancreas . Insulin promotes the storage of glucose and the uptake of amino acids, increases protein and lipid synthesis, and inhibits lipolysis and gluconeogenesis. Secretion of insulin is a response of the beta cells to a stimulus; the primary stimulus is glucose, and others are amino acids and hormones such as secretin, pancreozymin , and gastrin . These chemicals play an important role in maintaining normal blood glucose levels by triggering insulin release after a meal. After insulin is released from the beta cells, it enters the blood stream and is transported to cells throughout the body. The cell membranes have insulin receptors to which the hormone becomes bonded or fixed. An interaction between the insulin and its receptors leads to biochemical processes that include (1) the transport of glucose, amino acids, and certain ions across the membrane and into the cell body; (2) the storage of glycogen in liver and muscle cells; (3) the synthesis of triglycerides and storage of fat; (4) the synthesis of protein, RNA, and DNA, and (5) inhibition of gluconeogenesis, degradation of glycogen and protein, and lipolysis. Although insulin increases the transport of glucose across the cell membrane of most cells, in the brain glucose enters the cells by simple diffusion through the blood--brain barrier. 2. a preparation of the hormone, first discovered in 1921, used in treatment of diabetes mellitus ; it may be bovine or porcine in origin (prepared from the pancreas of the animals) or a re Continue reading >>

Humulin R U-500 Kwikpen Now Available

Humulin R U-500 Kwikpen Now Available

Eli Lilly announced the launch of Humulin R U-500 KwikPen Eli Lilly announced the launch of Humulin R U-500 KwikPen (insulin human injection), a prefilled device containing a highly concentrated formulation of insulin. The Food and Drug Administration (FDA) approved Humulin R U-500 KwikPen in January 2016. It is a man-made insulin used to control high blood sugar in adults and children with type 1 and type 2 diabetes who require >200 units of insulin daily. The U-500 formulation is 5 times more concentrated than the standard U-100 insulin, allowing patients with diabetes to inject up to 80% less liquid while receiving the required dose. RELATED: Extreme Insulin Requirements in Patient with Rare Genetic Disorder Insulins lower blood glucose by stimulating peripheral glucose uptake by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulins inhibit lipolysis and proteolysis, and enhance protein synthesis. The Humulin R U-500 is now available as 3mL KwikPens in 2- and 5-count cartons and as 20mL vials. For more information call (800) 545-5979 or visit Humulin.com . Continue reading >>

Can Insulin Go Back In The Fridge?

Can Insulin Go Back In The Fridge?

After removing insulin glargine (Lantus) from the refrigerator for use, can it be refrigerated over and over again after having warmed to room temperature, or does this degrade it? Continue reading >>

Drug Encyclopedia | Kaiser Permanente

Drug Encyclopedia | Kaiser Permanente

Learn about prescription and over-the-counter drugs how they work, possible side effects, and more. Don't see the drug you are looking for? Type the full drug name in the search box above. Don't know the drug name? Put asterisks before or after parts of the name you know (ex: *benzo*). Choose another search set, or input a search term If you suspect an overdose, contact your local poison control center or emergency room immediately. You can also call the National Poison Hotline at 1-800-222-1222 (toll free) or 711 (TTY). This information is intended to supplement, not substitute for, the expertise and judgment of your health care professional. The information is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate, or effective for you. You should consult your health care professional before taking any drug, changing your diet, or commencing or discontinuing any course of treatment. First Databank disclaims any liability for the decisions you make based on this information. Explore reliable information about the safe, effective use of vitamins, herbs, and other supplements and how they interact with other medications. Find out about drugs approved by the Kaiser Permanente Pharmacy and Therapeutics Committee for use in your care. Continue reading >>

The Abcs Of Insulin

The Abcs Of Insulin

Insulin is a naturally occurring hormone produced by the pancreas. Insulin is required to move sugar from the blood into the bodys cells, where it can be used for energy. For the symptoms of high blood sugar and low blood sugar, see Tables 1 and 2. Type 1 diabetes (T1D) is a chronic condition in which the pancreas produces little or no insulin. Only 5% of patients with diabetes have this form of the disease, according to the American Diabetes Association. Type 2 diabetes (T2D) is much more common; the risk factors are listed in online table 3. Individuals with T2D make insulin, but their bodies dont respond well to it, a condition known as insulin resistance. Treatment of T2D usually begins with dietary and lifestyle changes, as well as oral medications. Over time, as the pancreas struggles to make an adequate amount of insulin to overcome insulin resistance, patients may require insulin supplementation. Insulin therapy must be individualized and balanced with meal planning and exercise. When a patient begins using insulin to manage diabetes, the initial dose is just a starting point. Over time, insulin requirements are affected by factors such as weight gain or loss, changes in eating habits, and the addition of other medications. The need for insulin often increases, and the dose must be readjusted to meet the new requirements. Insulin is injected subcutaneously, meaning not very deep under the skin. Common injection sites include the stomach, buttocks, thighs, and upper arms. By rotating the site of injection, patients can avoid lipohypertrophy, a slight increase in the growth or size of fat cells under the skin. When lipohypertrophy occurs, a soft pillowy growth may form at the repeated-use injection site. Therefore, for reliable absorption rates and cosmetic purpo Continue reading >>

Short-acting Insulins

Short-acting Insulins

Rapid-Acting Analogues Short-Acting Insulins Intermediate-Acting Insulins Long-Acting Insulins Combination Insulins Onset: 30 minutes Peak: 2.5 - 5 hours Duration: 4 - 12 hours Solution: Clear Comments: Best if administered 30 minutes before a meal. Mixing NPH: If Regular insulin is mixed with NPH human insulin, the Regular insulin should be drawn into the syringe first. Aspart - Novolog ®: Compatible - but NO support clinically for such a mixture. Draw up Novolog first before drawing up Regular Insulin. Lispro - Humalog ®: Compatible - but NO support clinically for such a mixture. Draw up Humalog first before drawing up Regular Insulin. Mixtures should not be administered intravenously. When mixing insulin in a syringe, draw up the quickest acting insulin first (e.g. draw up Humalog or Novolog before drawing up Regular Insulin, or draw up Regular insulin before Novolin N (NPH) or Lente insulin. CLINICAL PHARMACOLOGY Insulin is a polypeptide hormone that controls the storage and metabolism of carbohydrates, proteins, and fats. This activity occurs primarily in the liver, in muscle, and in adipose tissues after binding of the insulin molecules to receptor sites on cellular plasma membranes. Insulin promotes uptake of carbohydrates, proteins, and fats in most tissues. Also, insulin influences carbohydrate, protein, and fat metabolism by stimulating protein and free fatty acid synthesis, and by inhibiting release of free fatty acid from adipose cells. Insulin increases active glucose transport through muscle and adipose cellular membranes, and promotes conversion of intracellular glucose and free fatty acid to the appropriate storage forms (glycogen and triglyceride, respectively). Although the liver does not require active glucose transport, insulin increases hepatic gl Continue reading >>

Regular-insulin, Injectable Solution

Regular-insulin, Injectable Solution

Insulin regular (human) injectable solution is available as brand-name drugs. It’s not available in a generic form. Brand names: HumuLIN R, NovoLIN R. Insulin regular (human) comes in three forms: injectable solution, powder for inhalation, and an intravenous injection. Insulin regular (human) injectable solution is used along with a healthy diet and exercise to control high blood sugar caused by type 1 or type 2 diabetes. Low blood sugar warning: Insulin regular (human) can cause low blood sugar (hypoglycemia). If you have a low blood sugar reaction, you’ll need to treat it right away. Symptoms can include: hunger dizziness shakiness lightheadedness sweating irritability headache fast heart rate confusion Thiazolidinedione warning: Taking certain diabetes pills called thiazolidinediones (TZDs) with insulin regular (human) may cause heart failure in some people. This can happen even if you’ve never had heart failure or heart problems before. If you already have heart failure, it may get worse. Your healthcare provider should monitor you closely while you’re taking TZDs with insulin regular (human). Tell your doctor right away if you have new or worse symptoms of heart failure, including: shortness of breath swelling of your ankles or feet sudden weight gain Infection warning: Do not share insulin vials, syringes or prefilled pens with other people. Sharing or reusing needles or syringes with another person puts you and others at risk for various infections. Insulin regular (human) is available as an over-the-counter (OTC) and prescription drug. It comes as a solution that you inject subcutaneously (under your skin). Your healthcare provider will show you how to give yourself the injection. You can also follow this guide for self-injection. Insulin regular (human Continue reading >>

Insulin Injection

Insulin Injection

Insulin injection is used to control blood sugar in people who have type 1 diabetes (condition in which the body does not make insulin and therefore cannot control the amount of sugar in the blood) or in people who have type 2 diabetes (condition in which the blood sugar is too high because the body does not produce or use insulin normally) that cannot be controlled with oral medications alone. Insulin injection is in a class of medications called hormones. Insulin injection is used to take the place of insulin that is normally produced by the body. It works by helping move sugar from the blood into other body tissues where it is used for energy. It also stops the liver from producing more sugar. All of the types of insulin that are available work in this way. The types of insulin differ only in how quickly they begin to work and how long they continue to control blood sugar. Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Using medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes. Insulin comes as a solution (liquid) and a suspension (liquid with particles that will settle on standing) to be injected subcutaneousl Continue reading >>

Humulin R

Humulin R

HUMULIN®R (regular insulin human) Injection, USP (rDNA Origin) 100 Units per ML (U-100) DESCRIPTION Humulin® R U-100 is a polypeptide hormone structurally identical to human insulin synthesized through rDNA technology in a special non-disease-producing laboratory strain of Escherichia coli bacteria. Humulin R (insulin human recombinant) U-100 has the empirical formula C257H383N65O77S6 and a molecular weight of 5808. Humulin R (insulin human recombinant) U-100 is a sterile, clear, aqueous, and colorless solution that contains human insulin (rDNA origin) 100 units/mL, glycerin 16 mg/mL and metacresol 2.5 mg/mL, endogenous zinc (approximately 0.015 mg/100 units) and water for injection. The pH is 7.0 to 7.8. Sodiumhydroxide and/or hydrochloric acid may be added during manufacture to adjust the pH. Adequate insulin dosage permits patients with diabetes to effectively utilize carbohydrates, proteins and fats. Regardless of dose strength, insulin enables carbohydrate metabolism to occur and thus to prevent the production of ketone bodies by the liver. Some patients develop severe insulin resistance such that daily doses of several hundred units of insulin or more are required. Continue reading >>

U-500 Insulin: Not For Ordinary Use

U-500 Insulin: Not For Ordinary Use

US Pharm. 2010;35(5)(Diabetes suppl):14-17. If not already seeing them, pharmacists should anticipate encountering prescriptions for U-500 regular insulin. U-500 insulin is five times more potent than standard U-100 and is utilized in patients requiring high doses of insulin. Prescribing of U-500 is on the rise due to the obesity epidemic, adoption of tighter glucose control protocols, increased insulin resistance, and utilization of insulin pumps.1 Potential for adverse drug events exists due to unfamiliarity with U-500 and its higher potency. This review is intended to enable safe provision of U-500 insulin by increasing awareness of the drug and its correct administration. As insulin resistance worsens, greater doses of insulin are required to meet glycemic goals. This is especially true for persons with insulin resistance (IR) syndromes. These are patients with an insulin requirement of 200 U/day and greater. FIGURE 1 illustrates the body’s response to insulin as the dose increases. Note that for patients with IR syndromes, the dose response to insulin is significantly diminished. This is especially true when insulin doses exceed 100 U. However, this phenomenon does not mean greater doses are without effect.2 In fact, higher doses of insulin eventually achieve therapeutic targets. For this reason, use of high-dose insulin should not be avoided in insulin-resistant patients. Otherwise, these patients will fail to achieve glycemic goals by underdosing insulin. Use of standard insulin becomes problematic when patients require over 200 U/day or greater than 100 U per injection. At these doses, the volume of U-100 insulin is physically too large for single subcutaneous administration, and multiple injections are required to deliver a single dose. With more injections, Continue reading >>

Indication For Humulin R U-500

Indication For Humulin R U-500

What is the most important information I should know about Humulin R U-500? Do not share your Humulin R U-500 KwikPen or U-500 insulin syringes with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them. Do not take Humulin R U-500 if your blood sugar is too low (hypoglycemia) or you are allergic to any of the ingredients in Humulin R U-500. Tell your healthcare provider: If you have liver, kidney, or heart problems or any other medical conditions. If you are pregnant, plan to become pregnant, or are breast-feeding. About all the medicines you take, including prescription (especially ones commonly called TZDs [thiazolidinediones]) and over the counter medicines, vitamins, and herbal supplements. Before you start using Humulin R U-500, talk to your healthcare provider about low blood sugar and how to manage it. Take Humulin R U-500 exactly as your healthcare provider tells you to. Your healthcare provider should show you how much Humulin R U-500 to use and when to use it. Check your insulin label each time you give your injection to make sure you are using the correct insulin. Humulin R U-500 KwikPen: The U-500 KwikPen is specially made to dial and deliver doses of Humulin R U-500 insulin. Do not use any syringe to remove Humulin R U-500 insulin from your U-500 KwikPen. The markings on certain syringes will not measure your dose correctly. A severe overdose can happen, causing low blood sugar, which may put your life in danger. Humulin R U-500 vial: There is a special U-500 insulin syringe to measure Humulin R U-500. Use only a U-500 insulin syringe to draw up and inject your Humulin R U-500. If you do not use the right syringe type, you may take the wrong dose of Humulin R U-500. This can ca Continue reading >>

How To Use Humulin® R U-500

How To Use Humulin® R U-500

What is the most important information I should know about Humulin R U-500? Do not share your Humulin R U-500 KwikPen or U-500 insulin syringes with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them. Tell your healthcare provider: If you have liver, kidney, or heart problems or any other medical conditions. If you are pregnant, plan to become pregnant, or are breast-feeding. About all the medicines you take, including prescription (especially ones commonly called TZDs [thiazolidinediones]) and over the counter medicines, vitamins, and herbal supplements. Before you start using Humulin R U-500, talk to your healthcare provider about low blood sugar and how to manage it. Check your insulin label each time you give your injection to make sure you are using the correct insulin. Humulin R U-500 KwikPen: The U-500 KwikPen is specially made to dial and deliver doses of Humulin R U-500 insulin. Do not use any syringe to remove Humulin R U-500 insulin from your U-500 KwikPen. The markings on certain syringes will not measure your dose correctly. A severe overdose can happen, causing low blood sugar, which may put your life in danger. Humulin R U-500 vial: There is a special U-500 insulin syringe to measure Humulin R U-500. Use only a U-500 insulin syringe to draw up and inject your Humulin R U-500. If you do not use the right syringe type, you may take the wrong dose of Humulin R U-500. This can cause you to have too low blood sugar (hypoglycemia) or too high blood sugar (hyperglycemia). Your healthcare provider should show you how to draw up Humulin R U-500. Inject Humulin R U-500 under your skin (subcutaneously). Do not use Humulin R U-500 in an insulin pump or inject Humulin R U-500 into your Continue reading >>

Insulin Reaches Clinics, Patients Navigating Post-storm Life

Insulin Reaches Clinics, Patients Navigating Post-storm Life

Insulin Reaches Clinics, Patients Navigating Post-Storm Life Nestled in blue cold storage containers and between cold packs preserving a stable temperature from the humid San Juan air, precious vials of insulin were transported across the city Wednesday. As the transport unfolded, winds whipped up palm trees still ragged from Hurricane Marias winds three weeks ago, and a rainstorm earlier in the day brought sheets of water so constant that it was difficult to see. Direct Reliefs Andrew MacCalla and Ruben Bras of the Puerto Rico Primary Care Association transport insulin donated by Eli Lilly to a San Juan primary care clinic. (Lara Cooper/Direct Relief) The daily rains have left portions of the city in a blackout cycle. As fledgling power comes back, another set of brutal rains appears to snuff it out. Insulin must be kept cool, a challenge when power throughout the island is scarce. But many clinics and hospitals are running on generator power and have the ability to consistently refrigerate crucial items, like insulin and vaccines. The need for insulin was higher than ever at a San Juan health center called Health ProMed, where much of Wednesdays Eli Lilly-donated shipment was bound. Damage to the Barrio Obrero neighborhood of San Juan can be seen from the Health ProMed Clinics third story waiting room. (Lara Cooper/Direct Relief) The clinic sits in the Barrio Obrero neighborhood of San Juan, home to a significant population that has immigrated from elsewhere in the Caribbean, primarily from the Dominican Republic. The center serves about 15,000 patients a year, almost all of which are living in poverty, according to data from the Health Resources and Services Administration. Sixteen percent of ProMeds patients have been diagnosed with diabetes. The center has two cli Continue reading >>

Humulin R, 100 Units/ml - 10 Ml Vial

Humulin R, 100 Units/ml - 10 Ml Vial

Unfortunately our full catalog may not be displayed in your state. If you contact our Customer Support by one of the methods below, we will be able to assist you in locating the product you are looking for. As a VIPPS accredited pharmacy licensed and/or authorized in all 50 states, pharmacy regulation requires us to ask for your shipping zip code. WARNING: You`ve selected a custom quantity of . This means you only want dispensed. Are you sure you only want to order ? If you need assistance, let one of our customer service representatives help you: 1-800-748-7001. INSULIN ONLY SHIPS OUT OF OUR WAREHOUSE MONDAY THROUGH THURSDAY WE CANNOT SHIP INSULIN TO ANY US TERRITORY DUE TO INCONSISTENT ESTIMATED SHIPPING TIMES THAT MAY JEOPARDIZE THE INTEGRITY OF TEMPERATURE CONTROLLED MEDICATIONS UPS NEXT DAY AIR SHIPPING IN INSULATED COOLER PACK IS INCLUDED IN THE PRICING. By purchasing insulin from HealthWarehouse.com, you are asserting that you are over 18 years of age and that you intend to use this insulin for the treatment of diabetes or for another legitimate medical purpose. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs. NOTES: Do not share this medication, needles, or syringes with others. It is recommended you attend a diabetes education program to understand diabetes and all the important aspects of its treatment, including meals/diet, exercise, personal hygiene, medicat Continue reading >>

U.s. Food And Drug Administration Approves Humulin® R U-500 Kwikpen®

U.s. Food And Drug Administration Approves Humulin® R U-500 Kwikpen®

INDIANAPOLIS, Jan. 21, 2016 /PRNewswire/ -- The U.S. Food and Drug Administration (FDA) has approved Eli Lilly and Company's (NYSE: LLY) Humulin® R U-500 KwikPen®(insulin human injection) 500 units/mL, a pre-filled device containing Humulin R U-500, a highly concentrated formulation of insulin. Humulin R U-500 is the only FDA-approved insulin that is five-times more concentrated than standard U-100 insulin. This insulin is used to treat high blood sugar in people with type 1 and type 2 diabetes who need more than 200 units of insulin per day. The safety and efficacy of Humulin R U-500 used in combination with other insulins or delivered by an insulin infusion pump has not been determined. "People with diabetes and severe insulin resistance who have become poorly responsive to the effects of insulin may require much higher insulin doses – more than 200 units per day – to help keep their blood sugar levels on target," said Jeffrey A. Jackson, MD, FACE, CDE, Medical Fellow, US Medical Affairs, Lilly Diabetes. "For these patients, the U-500 KwikPen is now available as a convenient alternate option to deliver a large dose of insulin in a reasonable volume. It was specifically designed as a dedicated dosing device to eliminate the need for dose conversion, as compared to use of the vial and syringe options, which some people may find to be an improvement." Until now, Humulin R U-500 was only available in a vial, administered with either a U-100 insulin syringe or a volumetric (tuberculin) syringe that requires conversion to respective syringe "unit markings" or volume markings. Although each U-500 KwikPen holds 1500 units of insulin (the amount in five U-100 insulin pens), it is the same size as other KwikPens and dials in five-unit increments. The U-500 KwikPen has a u Continue reading >>

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