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Humulin R Storage

Humulin R: Solution For Injection (100u)

Humulin R: Solution For Injection (100u)

Brand 100% *Brand contains same active ingredient but may not represent FDA-approved generic equivalent 100U Ingredients Close All Sections Reported Side Effects for Humulin R 100units/ml Solution for Injection Close *This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different. Close Class B - Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women. OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester. Class B - Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women. OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester. Class B - Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women. OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester. Continue reading >>

Humulin R U-500 Kwikpen Now Available

Humulin R U-500 Kwikpen Now Available

Eli Lilly announced the launch of Humulin R U-500 KwikPen Eli Lilly announced the launch of Humulin R U-500 KwikPen (insulin human injection), a prefilled device containing a highly concentrated formulation of insulin. The Food and Drug Administration (FDA) approved Humulin R U-500 KwikPen in January 2016. It is a man-made insulin used to control high blood sugar in adults and children with type 1 and type 2 diabetes who require >200 units of insulin daily. The U-500 formulation is 5 times more concentrated than the standard U-100 insulin, allowing patients with diabetes to inject up to 80% less liquid while receiving the required dose. RELATED: Extreme Insulin Requirements in Patient with Rare Genetic Disorder Insulins lower blood glucose by stimulating peripheral glucose uptake by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulins inhibit lipolysis and proteolysis, and enhance protein synthesis. The Humulin R U-500 is now available as 3mL KwikPens in 2- and 5-count cartons and as 20mL vials. For more information call (800) 545-5979 or visit Humulin.com . Continue reading >>

Can Insulin Go Back In The Fridge?

Can Insulin Go Back In The Fridge?

After removing insulin glargine (Lantus) from the refrigerator for use, can it be refrigerated over and over again after having warmed to room temperature, or does this degrade it? Continue reading >>

Regular-insulin, Injectable Solution

Regular-insulin, Injectable Solution

Insulin regular (human) injectable solution is available as brand-name drugs. It’s not available in a generic form. Brand names: HumuLIN R, NovoLIN R. Insulin regular (human) comes in three forms: injectable solution, powder for inhalation, and an intravenous injection. Insulin regular (human) injectable solution is used along with a healthy diet and exercise to control high blood sugar caused by type 1 or type 2 diabetes. Low blood sugar warning: Insulin regular (human) can cause low blood sugar (hypoglycemia). If you have a low blood sugar reaction, you’ll need to treat it right away. Symptoms can include: hunger dizziness shakiness lightheadedness sweating irritability headache fast heart rate confusion Thiazolidinedione warning: Taking certain diabetes pills called thiazolidinediones (TZDs) with insulin regular (human) may cause heart failure in some people. This can happen even if you’ve never had heart failure or heart problems before. If you already have heart failure, it may get worse. Your healthcare provider should monitor you closely while you’re taking TZDs with insulin regular (human). Tell your doctor right away if you have new or worse symptoms of heart failure, including: shortness of breath swelling of your ankles or feet sudden weight gain Infection warning: Do not share insulin vials, syringes or prefilled pens with other people. Sharing or reusing needles or syringes with another person puts you and others at risk for various infections. Insulin regular (human) is available as an over-the-counter (OTC) and prescription drug. It comes as a solution that you inject subcutaneously (under your skin). Your healthcare provider will show you how to give yourself the injection. You can also follow this guide for self-injection. Insulin regular (human Continue reading >>

U.s. Food And Drug Administration Approves Humulin® R U-500 Kwikpen®

U.s. Food And Drug Administration Approves Humulin® R U-500 Kwikpen®

INDIANAPOLIS, Jan. 21, 2016 /PRNewswire/ -- The U.S. Food and Drug Administration (FDA) has approved Eli Lilly and Company's (NYSE: LLY) Humulin® R U-500 KwikPen®(insulin human injection) 500 units/mL, a pre-filled device containing Humulin R U-500, a highly concentrated formulation of insulin. Humulin R U-500 is the only FDA-approved insulin that is five-times more concentrated than standard U-100 insulin. This insulin is used to treat high blood sugar in people with type 1 and type 2 diabetes who need more than 200 units of insulin per day. The safety and efficacy of Humulin R U-500 used in combination with other insulins or delivered by an insulin infusion pump has not been determined. "People with diabetes and severe insulin resistance who have become poorly responsive to the effects of insulin may require much higher insulin doses – more than 200 units per day – to help keep their blood sugar levels on target," said Jeffrey A. Jackson, MD, FACE, CDE, Medical Fellow, US Medical Affairs, Lilly Diabetes. "For these patients, the U-500 KwikPen is now available as a convenient alternate option to deliver a large dose of insulin in a reasonable volume. It was specifically designed as a dedicated dosing device to eliminate the need for dose conversion, as compared to use of the vial and syringe options, which some people may find to be an improvement." Until now, Humulin R U-500 was only available in a vial, administered with either a U-100 insulin syringe or a volumetric (tuberculin) syringe that requires conversion to respective syringe "unit markings" or volume markings. Although each U-500 KwikPen holds 1500 units of insulin (the amount in five U-100 insulin pens), it is the same size as other KwikPens and dials in five-unit increments. The U-500 KwikPen has a u Continue reading >>

Humulin 30/70/humulin N/humulin R Presentation / Storage

Humulin 30/70/humulin N/humulin R Presentation / Storage

Humulin R, Humulin N, Humulin 30/70 vial: HUMULIN R: A sterile, clear colorless, aqueous solution of human insulin (DNA) adjusted to a pH of 7.0 to 7.8. Contains m-Cresol 0.25% added during manufacture as a preservative. HUMULIN N: A sterile suspension of a white, crystalline precipitate of isophane human insulin (DNA) in an isotonic phosphate buffer adjusted to a pH of 6.9 to 7.5. Contains m-Cresol 0.16% and phenol 0.065% added during manufacture as a preservative. HUMULIN 30/70: A sterile suspension of human insulin in the proportion of 30% soluble insulin and 70% isophane insulin. Contains m-Cresol 0.16% and phenol 0.065% added during manufacture as a preservative. Humulin R, Humulin N, Humulin 30/70 cartridge: 1 ml contains 100 IU human insulin (produced in E. coli by recombinant DNA technology). Humulin N: One cartridge contains 3 ml equivalent to 300 IU of isophane insulin. Humulin 30/70: One cartridge contains 3 ml equivalent to 300 IU of biphasic isophane insulin - 30 % soluble insulin/70 % isophane insulin. Humulin R: One cartridge contains 3 ml equivalent to 300 IU of soluble insulin. Humulin N: A suspension for injection in a cartridge. Humulin N is a sterile suspension of a white, crystalline precipitate of isophane human insulin in an isotonic phosphate buffer. Humulin 30/70: A suspension for injection in a cartridge. Humulin 30/70 is a sterile suspension of human insulin in the proportion of 30 % soluble insulin to 70 % isophane insulin. Humulin R: A solution for injection in a cartridge. Humulin R is a sterile, clear, colourless, aqueous solution of human insulin. Excipients/Inactive Ingredients: Humulin R, Humulin N, Humulin 30/70 vial: Humulin N or Humulin 30/70: m-cresol, glycerol, phenol, protamine sulphate,, dibasic sodium phosphate 7H2O, zinc oxide Continue reading >>

Humulin R U-500 Vial

Humulin R U-500 Vial

Uses Concentrated insulin regular is used with a proper diet and exercise program to control high blood sugar in people with diabetes who require large doses of insulin (more than 200 units per day). Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. This man-made insulin product is the same as human insulin. It replaces the insulin that your body would normally make. It works right away like regular insulin but its effects last longer. It works by helping blood sugar (glucose) get into cells so your body can use it for energy. This medication may be used alone or with other oral diabetes drugs (such as metformin). How to use Humulin R U-500 Vial Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor, diabetes educator, or pharmacist. This insulin product is a high-strength concentrated liquid. Learn all preparation and usage instructions from your health care professional and the product package. If you are using the vial, use the proper syringe prescribed by your doctor to make sure you are measuring the correct dose. Before using, check this product visually for particles or discoloration. If either is present, do not use the insulin. This insulin product should be clear and colorless. Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin and to avoid developing problems under the skin (lipodystrophy). This insulin product may be injected in the stomach area, the thigh, the buttocks, or the back of t Continue reading >>

The Abcs Of Insulin

The Abcs Of Insulin

Insulin is a naturally occurring hormone produced by the pancreas. Insulin is required to move sugar from the blood into the bodys cells, where it can be used for energy. For the symptoms of high blood sugar and low blood sugar, see Tables 1 and 2. Type 1 diabetes (T1D) is a chronic condition in which the pancreas produces little or no insulin. Only 5% of patients with diabetes have this form of the disease, according to the American Diabetes Association. Type 2 diabetes (T2D) is much more common; the risk factors are listed in online table 3. Individuals with T2D make insulin, but their bodies dont respond well to it, a condition known as insulin resistance. Treatment of T2D usually begins with dietary and lifestyle changes, as well as oral medications. Over time, as the pancreas struggles to make an adequate amount of insulin to overcome insulin resistance, patients may require insulin supplementation. Insulin therapy must be individualized and balanced with meal planning and exercise. When a patient begins using insulin to manage diabetes, the initial dose is just a starting point. Over time, insulin requirements are affected by factors such as weight gain or loss, changes in eating habits, and the addition of other medications. The need for insulin often increases, and the dose must be readjusted to meet the new requirements. Insulin is injected subcutaneously, meaning not very deep under the skin. Common injection sites include the stomach, buttocks, thighs, and upper arms. By rotating the site of injection, patients can avoid lipohypertrophy, a slight increase in the growth or size of fat cells under the skin. When lipohypertrophy occurs, a soft pillowy growth may form at the repeated-use injection site. Therefore, for reliable absorption rates and cosmetic purpo Continue reading >>

Insulin

Insulin

insulin [in´su-lin] 1. the major fuel-regulating hormone of the body, a double-chain protein formed from proinsulin in the beta cells of the islets of Langerhans in the pancreas. Insulin promotes the storage of glucose and the uptake of amino acids, increases protein and lipid synthesis, and inhibits lipolysis and gluconeogenesis. Secretion of insulin is a response of the beta cells to a stimulus; the primary stimulus is glucose, and others are amino acids and hormones such as secretin, pancreozymin, and gastrin. These chemicals play an important role in maintaining normal blood glucose levels by triggering insulin release after a meal. After insulin is released from the beta cells, it enters the blood stream and is transported to cells throughout the body. The cell membranes have insulin receptors to which the hormone becomes bonded or “fixed.” An interaction between the insulin and its receptors leads to biochemical processes that include (1) the transport of glucose, amino acids, and certain ions across the membrane and into the cell body; (2) the storage of glycogen in liver and muscle cells; (3) the synthesis of triglycerides and storage of fat; (4) the synthesis of protein, RNA, and DNA, and (5) inhibition of gluconeogenesis, degradation of glycogen and protein, and lipolysis. Although insulin increases the transport of glucose across the cell membrane of most cells, in the brain glucose enters the cells by simple diffusion through the blood--brain barrier. 2. a preparation of the hormone, first discovered in 1921, used in treatment of diabetes mellitus; it may be bovine or porcine in origin (prepared from the pancreas of the animals) or a recombinant human type, although insulin of bovine origin is no longer available in the United States. Recombinant human Continue reading >>

Ptce Quiz 6 Review

Ptce Quiz 6 Review

How many days will it take a patient injecting 23 units of Humulin R insulin daily to complete a 10 ml vial? A. 30 days B. 23 days C. 43 days D. 14 days C. 43 days Which size needle and syringe would a very thin patient use if injecting 23 units of insulin daily? A. 1cc short 25 gauge B. 1/3 cc short 30 gauge C. ½ cc long 30 gauge D. 1/3 cc long 25 gauge B. 1/3 cc short 30 gauge Glucagon is used: A. When a patient has high blood sugar (hyperglycemia) B. As a substitute for sugar in their diets. C. When a patient has low blood sugar (hypoglycemia) D. daily with insulin injections to prevent hypoglycemia. C. For low blood sugar Type 1 diabetics would not use which medication? A. Lantus B. Glucagon C. Glucotrol D. Lispro C. Glucotrol Which insulin is cloudy? A. Humulin R B. Humulin N C. Lantus D. All the drugs listed are cloudy B. Humulin N Which statement is true regarding insulin and refrigeration? A. Insulin should never be refrigerated. B. Insulin should never be left outside of the refrigerator. C. Insulin is good for approximately 28 days outside of refrigeration. D. Insulin burns more when injected at room temperature. C. Which statement is true regarding Type 2 diabetes? A. Usually diagnosed during pregnancy. B. Only use insulin. C. Can use both insulin and oral medications. D. All of the answers are correct. C. Can use both insulin and oral medications. Type 1 diabetics can increase their pancreatic output of insulin by changing their diet and exercise. A. True B. False B. False Which insulin comes in an inhalation dosage form? A. Exubera B. Lantus C. Humalog D. Humulin 70/30 mix A. Exubera Which insulin can be given IV? A. Humulin R B. Humulin N C. Lantus D. Humalog mix 75/25 A. Humulin R What is the proper temperature for insulin storage? A. 10-20 degrees Fah Continue reading >>

Humulin R Regular U-100 Insuln

Humulin R Regular U-100 Insuln

Overview How to use Side effects Precautions Storage Drug interactions Overdose More Insulin regular is used with a proper diet and exercise program to control high blood sugar in people with diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. This man-made insulin product is the same as human insulin. It replaces the insulin that your body would normally make. It is a short-acting insulin. It works by helping blood sugar (glucose) get into cells so your body can use it for energy. This medication is usually used in combination with a medium- or long-acting insulin product. This medication may also be used alone or with other oral diabetes drugs (such as metformin). Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor, diabetes educator, or pharmacist. Learn all preparation and usage instructions from your health care professional and the product package. Before using, check this product visually for particles or discoloration. If either is present, do not use the insulin. Insulin regular should be clear and colorless. Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin and to avoid developing problems under the skin (lipodystrophy). Insulin regular may be injected in the stomach area, the thigh, the buttocks, or the back of the upper arm. Do not inject into a vein or muscle because very low blood sugar (hypoglycemia) may occur. Do not rub the area after the injection. Do not inject into s Continue reading >>

Humulin R

Humulin R

Generic Name: Insulin Regular (U-100) Vials (IN su lin) Brand Name: Humulin R, Novolin R Uses of Humulin R: It is used to lower blood sugar in patients with high blood sugar (diabetes). What do I need to tell my doctor BEFORE I take Humulin R? If you have an allergy to insulin or any other part of Humulin R (insulin regular (U-100) vials). If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have low blood sugar. This is not a list of all drugs or health problems that interact with this medicine. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Humulin R with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. What are some things I need to know or do while I take Humulin R? Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists. Allergic reactions have happened with Humulin R. Rarely, some reactions can be very bad or life-threatening. Talk with the doctor. Low blood sugar may happen with this medicine. Very low blood sugar can lead to seizures, passing out, long lasting brain damage, and sometimes death. Talk with the doctor. Low blood potassium may happen with Humulin R. If not treated, this can lead to a heartbeat that is not normal, very bad breathing problems, and sometimes death. Talk with the doctor. Avoid driving and doing other tasks or actions that Continue reading >>

Drug Encyclopedia | Kaiser Permanente

Drug Encyclopedia | Kaiser Permanente

Learn about prescription and over-the-counter drugs how they work, possible side effects, and more. Don't see the drug you are looking for? Type the full drug name in the search box above. Don't know the drug name? Put asterisks before or after parts of the name you know (ex: *benzo*). Choose another search set, or input a search term If you suspect an overdose, contact your local poison control center or emergency room immediately. You can also call the National Poison Hotline at 1-800-222-1222 (toll free) or 711 (TTY). This information is intended to supplement, not substitute for, the expertise and judgment of your health care professional. The information is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate, or effective for you. You should consult your health care professional before taking any drug, changing your diet, or commencing or discontinuing any course of treatment. First Databank disclaims any liability for the decisions you make based on this information. Explore reliable information about the safe, effective use of vitamins, herbs, and other supplements and how they interact with other medications. Find out about drugs approved by the Kaiser Permanente Pharmacy and Therapeutics Committee for use in your care. Continue reading >>

Humulin R (insulin Human Subcutaneous) - Summary

Humulin R (insulin Human Subcutaneous) - Summary

Humulin is synthesized in a special non-disease-producing laboratory strain of Escherichia coli bacteria that has been genetically altered by the addition of the gene for human insulin production. HumulinR(U-500) consists of zinc-insulin crystals dissolved in a clear fluid. HumulinR(U-500) is a sterile solution and is for subcutaneous injection. It should not be used intravenously or intramuscularly. The concentration of HumulinR(U-500) is 500units/mL.Each milliliter contains 500units of biosynthetic human insulin, 16mg glycerin, 2.5mgMetacresol as a preservative, and zinc-oxide calculated to supplement endogenous zinc to obtain a total zinc content of 0.017mg/100units. Sodium hydroxide and/or hydrochloric acid may be added during manufacture to adjust the pH. HUMULIN R (insulin human SUBCUTANEOUS) is indicated for the following: HumulinR(U-500) is especially useful for the treatment of diabetic patients with marked insulin resistance (daily requirements more than 200units), since a large dose may be administered subcutaneously in a reasonable volume. Comparative pharmacokinetics and insulin action for three rapid-acting insulinanalogs injected subcutaneously with and without hyaluronidase. [2013] CONCLUSIONS: Coinjection of rHuPH20 with rapid-acting analogs accelerated insulin Phase IV study comparing diurnal glycemic profile following the administration of2 NPH plus regular human DNA recombinant insulin regimens in type 1 diabetesmellitus (T1DM) adult patients. [2012] Intensive insulin therapy (IIT) based on multiple daily injections of long plusrapid-acting insulin has been demonstrated to reduce mortality and morbidityassociated with chronic hyperglycemia in T1DM patients. The objective of thisstudy was to assess and compare the postprandial glycemic profile over a Continue reading >>

How To Use Humulin® R U-500

How To Use Humulin® R U-500

What is the most important information I should know about Humulin R U-500? Do not share your Humulin R U-500 KwikPen or U-500 insulin syringes with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them. Tell your healthcare provider: If you have liver, kidney, or heart problems or any other medical conditions. If you are pregnant, plan to become pregnant, or are breast-feeding. About all the medicines you take, including prescription (especially ones commonly called TZDs [thiazolidinediones]) and over the counter medicines, vitamins, and herbal supplements. Before you start using Humulin R U-500, talk to your healthcare provider about low blood sugar and how to manage it. Check your insulin label each time you give your injection to make sure you are using the correct insulin. Humulin R U-500 KwikPen: The U-500 KwikPen is specially made to dial and deliver doses of Humulin R U-500 insulin. Do not use any syringe to remove Humulin R U-500 insulin from your U-500 KwikPen. The markings on certain syringes will not measure your dose correctly. A severe overdose can happen, causing low blood sugar, which may put your life in danger. Humulin R U-500 vial: There is a special U-500 insulin syringe to measure Humulin R U-500. Use only a U-500 insulin syringe to draw up and inject your Humulin R U-500. If you do not use the right syringe type, you may take the wrong dose of Humulin R U-500. This can cause you to have too low blood sugar (hypoglycemia) or too high blood sugar (hyperglycemia). Your healthcare provider should show you how to draw up Humulin R U-500. Inject Humulin R U-500 under your skin (subcutaneously). Do not use Humulin R U-500 in an insulin pump or inject Humulin R U-500 into your Continue reading >>

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