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Humulin R Storage

U-500 Insulin: Not For Ordinary Use

U-500 Insulin: Not For Ordinary Use

US Pharm. 2010;35(5)(Diabetes suppl):14-17. If not already seeing them, pharmacists should anticipate encountering prescriptions for U-500 regular insulin. U-500 insulin is five times more potent than standard U-100 and is utilized in patients requiring high doses of insulin. Prescribing of U-500 is on the rise due to the obesity epidemic, adoption of tighter glucose control protocols, increased insulin resistance, and utilization of insulin pumps.1 Potential for adverse drug events exists due to unfamiliarity with U-500 and its higher potency. This review is intended to enable safe provision of U-500 insulin by increasing awareness of the drug and its correct administration. As insulin resistance worsens, greater doses of insulin are required to meet glycemic goals. This is especially true for persons with insulin resistance (IR) syndromes. These are patients with an insulin requirement of 200 U/day and greater. FIGURE 1 illustrates the body’s response to insulin as the dose increases. Note that for patients with IR syndromes, the dose response to insulin is significantly diminished. This is especially true when insulin doses exceed 100 U. However, this phenomenon does not mean greater doses are without effect.2 In fact, higher doses of insulin eventually achieve therapeutic targets. For this reason, use of high-dose insulin should not be avoided in insulin-resistant patients. Otherwise, these patients will fail to achieve glycemic goals by underdosing insulin. Use of standard insulin becomes problematic when patients require over 200 U/day or greater than 100 U per injection. At these doses, the volume of U-100 insulin is physically too large for single subcutaneous administration, and multiple injections are required to deliver a single dose. With more injections, Continue reading >>

Indication For Humulin R U-500

Indication For Humulin R U-500

If your A1C is uncontrolled on high doses of standard insulin—more than 200 units a day—you may have another diabetes treatment option. Humulin® R U-500 is 5x concentrated insulin* available in a U-500 KwikPen® or syringe and vial. U-500 lowered high blood sugar in a clinical study. † If your doctor has prescribed U-500 for you or a loved one, learn more here. † 24 week, open-label, randomized trial to compare the efficacy and safety of 2 dosing regiments (TID, n=162 vs BID, n=163) for U-500 insulin replacing high dose U-100 insulin (>200 units per day) with or without oral antihyperglycemic drugs in adult patients with uncontrolled type 2 diabetes. These regimens were found to be equivalent for A1C reduction over 24 weeks, and both were efficacious. Study conducted with U-100 insulin syringes and Humulin R U-500 vials. Continue reading >>

How Long Should Insulin Be Used Once A Vial Is Started?

How Long Should Insulin Be Used Once A Vial Is Started?

Editor’s comment: The commentary by Dr. Grajower has such important clinical relevance that responses were invited from the three pharmaceutical companies that supply insulin in the U.S. and the American Diabetes Association, and all of these combined in this commentary. The commenting letter and individual responses were authored separately and are completely independent of each other. Diabetic patients treated with insulin, whether for type 1 or type 2 diabetes, are prone to often unexplained swings in their blood glucose. These swings can vary from dangerously low to persistently high levels. Most diabetic patients, and most physicians, will adjust insulin regimens so as to avoid hypoglycemia at the expense of hyperglycemia. Among the “textbook” reasons for variable glucose responses to any given insulin regimen are 1) site of administration, 2) exercise, 3) bottles not adequately mixed before drawing the insulin (for NPH, Lente, or Ultralente), and 4) duration of treatment with insulin (1). A new insulin was marketed by Aventis Pharmaceuticals about 1 year ago, insulin glargine (Lantus). The manufacturer seemed to stress that patients not use a started bottle of this insulin for >28 days (2). Two patients of mine highlighted this point. L.K. is a 76-year-old woman with type 2 diabetes, diagnosed at 55 years of age, and treated with insulin since age 56. Her insulin regimen was changed to Lantus at night together with Novolog before meals. She monitors her blood glucose four times a day. She used a bottle of Lantus until it ran out; therefore, a bottle lasted for 2 months. Her recent HbA1c was 7.6%. I retrospectively analyzed her home glucose readings by averaging her fasting blood glucose levels for the first 15 days of a new bottle and the last 15 days of tha Continue reading >>

U.s. Food And Drug Administration Approves Humulin® R U-500 Kwikpen®

U.s. Food And Drug Administration Approves Humulin® R U-500 Kwikpen®

INDIANAPOLIS, Jan. 21, 2016 /PRNewswire/ -- The U.S. Food and Drug Administration (FDA) has approved Eli Lilly and Company's (NYSE: LLY) Humulin® R U-500 KwikPen®(insulin human injection) 500 units/mL, a pre-filled device containing Humulin R U-500, a highly concentrated formulation of insulin. Humulin R U-500 is the only FDA-approved insulin that is five-times more concentrated than standard U-100 insulin. This insulin is used to treat high blood sugar in people with type 1 and type 2 diabetes who need more than 200 units of insulin per day. The safety and efficacy of Humulin R U-500 used in combination with other insulins or delivered by an insulin infusion pump has not been determined. "People with diabetes and severe insulin resistance who have become poorly responsive to the effects of insulin may require much higher insulin doses – more than 200 units per day – to help keep their blood sugar levels on target," said Jeffrey A. Jackson, MD, FACE, CDE, Medical Fellow, US Medical Affairs, Lilly Diabetes. "For these patients, the U-500 KwikPen is now available as a convenient alternate option to deliver a large dose of insulin in a reasonable volume. It was specifically designed as a dedicated dosing device to eliminate the need for dose conversion, as compared to use of the vial and syringe options, which some people may find to be an improvement." Until now, Humulin R U-500 was only available in a vial, administered with either a U-100 insulin syringe or a volumetric (tuberculin) syringe that requires conversion to respective syringe "unit markings" or volume markings. Although each U-500 KwikPen holds 1500 units of insulin (the amount in five U-100 insulin pens), it is the same size as other KwikPens and dials in five-unit increments. The U-500 KwikPen has a u Continue reading >>

Humulin R (cartridge) Solution For Injection

Humulin R (cartridge) Solution For Injection

Humulin R (Cartridge) Solution for injection Humulin R (Cartridge) Solution for injection Humulin R (Cartridge) Solution for injection Consumer medicine information (CMI) leaflet Please read this leaflet carefully before you start using Humulin R (Cartridge) Solution for injection. This leaflet answers some common questions about HUMULIN. It does not contain all the available information. It does not take the place of talking with your doctor or pharmacist. The information in this leaflet was last updated on the date shown on the final page. More recent information on this medicine may be available. Make sure you speak to your pharmacist, nurse or doctor to obtain the most up to date information on this medicine. You can also download the most up to date leaflet from www.lilly.com.au. The updated leaflet may contain important information about HUMULIN and its use that you should be aware of. Your doctor has weighed the risks of you taking HUMULIN against the benefits they expect it will have for you. If you have any concerns about using this medicine, ask your doctor or pharmacist. HUMULIN is used to reduce high blood sugar (glucose) levels in patients with diabetes mellitus. Diabetes is a condition in which your pancreas does not produce enough insulin to control your blood sugar level. Extra insulin is therefore needed. There are two types of diabetes mellitus: Type 1 diabetes - also called juvenile onset diabetes. Type 2 diabetes - also called maturity onset diabetes. Patients with type 1 diabetes always require insulin to control their blood sugar levels. Some patients with type 2 diabetes may also require insulin after initial treatment with diet, exercise and tablets. HUMULIN is identical to the insulin produced by the pancreas. There are 3 different types of HUM Continue reading >>

Humulin R Price Comparison: Uses, Dosage, Form & Side Effects

Humulin R Price Comparison: Uses, Dosage, Form & Side Effects

It is very important to know about what medicine is given by the doctor, for what condition, and when it needs to be taken in what dose. This information given by the doctor is called Prescription. The patients should be familiar with the medicine prescription, and the details about the medicine before purchasing it and using it. Some medications need not be prescribed by healthcare practitioners and can be purchased and used without prescription by the patients; these are called over-the-counter medications. Read the drug prescription information of Humulin R before taking it. Humulin is synthesized in a special non-disease-producing laboratory strain of Escherichia coli bacteria that has been genetically altered by the addition of the gene for human insulin production. HumulinR(U-500) consists of zinc-insulin crystals dissolved in a clear fluid. HumulinR(U-500) is a sterile solution and is for subcutaneous injection. It should not be used intravenously or intramuscularly. The concentration of HumulinR(U-500) is 500units/mL.Each milliliter contains 500units of biosynthetic human insulin, 16mg glycerin, 2.5mgMetacresol as a preservative, and zinc-oxide calculated to supplement endogenous zinc to obtain a total zinc content of 0.017mg/100units. Sodium hydroxide and/or hydrochloric acid may be added during manufacture to adjust the pH. Humulin R (insulin human SUBCUTANEOUS) is indicated for the following: HumulinR(U-500) is especially useful for the treatment of diabetic patients with marked insulin resistance (daily requirements more than 200units), since a large dose may be administered subcutaneously in a reasonable volume. Humulin R is a form of insulin usually used to treat diabetes. Some of the most prescribed drugs in this class include: Lantus; Humalog; Novolog; Continue reading >>

Humulin R (insulin Human Subcutaneous) - Summary

Humulin R (insulin Human Subcutaneous) - Summary

Humulin is synthesized in a special non-disease-producing laboratory strain of Escherichia coli bacteria that has been genetically altered by the addition of the gene for human insulin production. HumulinR(U-500) consists of zinc-insulin crystals dissolved in a clear fluid. HumulinR(U-500) is a sterile solution and is for subcutaneous injection. It should not be used intravenously or intramuscularly. The concentration of HumulinR(U-500) is 500units/mL.Each milliliter contains 500units of biosynthetic human insulin, 16mg glycerin, 2.5mgMetacresol as a preservative, and zinc-oxide calculated to supplement endogenous zinc to obtain a total zinc content of 0.017mg/100units. Sodium hydroxide and/or hydrochloric acid may be added during manufacture to adjust the pH. HUMULIN R (insulin human SUBCUTANEOUS) is indicated for the following: HumulinR(U-500) is especially useful for the treatment of diabetic patients with marked insulin resistance (daily requirements more than 200units), since a large dose may be administered subcutaneously in a reasonable volume. Comparative pharmacokinetics and insulin action for three rapid-acting insulinanalogs injected subcutaneously with and without hyaluronidase. [2013] CONCLUSIONS: Coinjection of rHuPH20 with rapid-acting analogs accelerated insulin Phase IV study comparing diurnal glycemic profile following the administration of2 NPH plus regular human DNA recombinant insulin regimens in type 1 diabetesmellitus (T1DM) adult patients. [2012] Intensive insulin therapy (IIT) based on multiple daily injections of long plusrapid-acting insulin has been demonstrated to reduce mortality and morbidityassociated with chronic hyperglycemia in T1DM patients. The objective of thisstudy was to assess and compare the postprandial glycemic profile over a Continue reading >>

Short-acting Insulins

Short-acting Insulins

Rapid-Acting Analogues Short-Acting Insulins Intermediate-Acting Insulins Long-Acting Insulins Combination Insulins Onset: 30 minutes Peak: 2.5 - 5 hours Duration: 4 - 12 hours Solution: Clear Comments: Best if administered 30 minutes before a meal. Mixing NPH: If Regular insulin is mixed with NPH human insulin, the Regular insulin should be drawn into the syringe first. Aspart - Novolog ®: Compatible - but NO support clinically for such a mixture. Draw up Novolog first before drawing up Regular Insulin. Lispro - Humalog ®: Compatible - but NO support clinically for such a mixture. Draw up Humalog first before drawing up Regular Insulin. Mixtures should not be administered intravenously. When mixing insulin in a syringe, draw up the quickest acting insulin first (e.g. draw up Humalog or Novolog before drawing up Regular Insulin, or draw up Regular insulin before Novolin N (NPH) or Lente insulin. CLINICAL PHARMACOLOGY Insulin is a polypeptide hormone that controls the storage and metabolism of carbohydrates, proteins, and fats. This activity occurs primarily in the liver, in muscle, and in adipose tissues after binding of the insulin molecules to receptor sites on cellular plasma membranes. Insulin promotes uptake of carbohydrates, proteins, and fats in most tissues. Also, insulin influences carbohydrate, protein, and fat metabolism by stimulating protein and free fatty acid synthesis, and by inhibiting release of free fatty acid from adipose cells. Insulin increases active glucose transport through muscle and adipose cellular membranes, and promotes conversion of intracellular glucose and free fatty acid to the appropriate storage forms (glycogen and triglyceride, respectively). Although the liver does not require active glucose transport, insulin increases hepatic gl Continue reading >>

Drug Encyclopedia | Kaiser Permanente

Drug Encyclopedia | Kaiser Permanente

Learn about prescription and over-the-counter drugs how they work, possible side effects, and more. Don't see the drug you are looking for? Type the full drug name in the search box above. Don't know the drug name? Put asterisks before or after parts of the name you know (ex: *benzo*). Choose another search set, or input a search term If you suspect an overdose, contact your local poison control center or emergency room immediately. You can also call the National Poison Hotline at 1-800-222-1222 (toll free) or 711 (TTY). This information is intended to supplement, not substitute for, the expertise and judgment of your health care professional. The information is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate, or effective for you. You should consult your health care professional before taking any drug, changing your diet, or commencing or discontinuing any course of treatment. First Databank disclaims any liability for the decisions you make based on this information. Explore reliable information about the safe, effective use of vitamins, herbs, and other supplements and how they interact with other medications. Find out about drugs approved by the Kaiser Permanente Pharmacy and Therapeutics Committee for use in your care. Continue reading >>

Ptce Quiz 6 Review

Ptce Quiz 6 Review

How many days will it take a patient injecting 23 units of Humulin R insulin daily to complete a 10 ml vial? A. 30 days B. 23 days C. 43 days D. 14 days C. 43 days Which size needle and syringe would a very thin patient use if injecting 23 units of insulin daily? A. 1cc short 25 gauge B. 1/3 cc short 30 gauge C. ½ cc long 30 gauge D. 1/3 cc long 25 gauge B. 1/3 cc short 30 gauge Glucagon is used: A. When a patient has high blood sugar (hyperglycemia) B. As a substitute for sugar in their diets. C. When a patient has low blood sugar (hypoglycemia) D. daily with insulin injections to prevent hypoglycemia. C. For low blood sugar Type 1 diabetics would not use which medication? A. Lantus B. Glucagon C. Glucotrol D. Lispro C. Glucotrol Which insulin is cloudy? A. Humulin R B. Humulin N C. Lantus D. All the drugs listed are cloudy B. Humulin N Which statement is true regarding insulin and refrigeration? A. Insulin should never be refrigerated. B. Insulin should never be left outside of the refrigerator. C. Insulin is good for approximately 28 days outside of refrigeration. D. Insulin burns more when injected at room temperature. C. Which statement is true regarding Type 2 diabetes? A. Usually diagnosed during pregnancy. B. Only use insulin. C. Can use both insulin and oral medications. D. All of the answers are correct. C. Can use both insulin and oral medications. Type 1 diabetics can increase their pancreatic output of insulin by changing their diet and exercise. A. True B. False B. False Which insulin comes in an inhalation dosage form? A. Exubera B. Lantus C. Humalog D. Humulin 70/30 mix A. Exubera Which insulin can be given IV? A. Humulin R B. Humulin N C. Lantus D. Humalog mix 75/25 A. Humulin R What is the proper temperature for insulin storage? A. 10-20 degrees Fah Continue reading >>

Humulin R, 100 Units/ml - 10 Ml Vial

Humulin R, 100 Units/ml - 10 Ml Vial

Unfortunately our full catalog may not be displayed in your state. If you contact our Customer Support by one of the methods below, we will be able to assist you in locating the product you are looking for. As a VIPPS accredited pharmacy licensed and/or authorized in all 50 states, pharmacy regulation requires us to ask for your shipping zip code. WARNING: You`ve selected a custom quantity of . This means you only want dispensed. Are you sure you only want to order ? If you need assistance, let one of our customer service representatives help you: 1-800-748-7001. INSULIN ONLY SHIPS OUT OF OUR WAREHOUSE MONDAY THROUGH THURSDAY WE CANNOT SHIP INSULIN TO ANY US TERRITORY DUE TO INCONSISTENT ESTIMATED SHIPPING TIMES THAT MAY JEOPARDIZE THE INTEGRITY OF TEMPERATURE CONTROLLED MEDICATIONS UPS NEXT DAY AIR SHIPPING IN INSULATED COOLER PACK IS INCLUDED IN THE PRICING. By purchasing insulin from HealthWarehouse.com, you are asserting that you are over 18 years of age and that you intend to use this insulin for the treatment of diabetes or for another legitimate medical purpose. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs. NOTES: Do not share this medication, needles, or syringes with others. It is recommended you attend a diabetes education program to understand diabetes and all the important aspects of its treatment, including meals/diet, exercise, personal hygiene, medicat Continue reading >>

Insulin Injection

Insulin Injection

Insulin injection is used to control blood sugar in people who have type 1 diabetes (condition in which the body does not make insulin and therefore cannot control the amount of sugar in the blood) or in people who have type 2 diabetes (condition in which the blood sugar is too high because the body does not produce or use insulin normally) that cannot be controlled with oral medications alone. Insulin injection is in a class of medications called hormones. Insulin injection is used to take the place of insulin that is normally produced by the body. It works by helping move sugar from the blood into other body tissues where it is used for energy. It also stops the liver from producing more sugar. All of the types of insulin that are available work in this way. The types of insulin differ only in how quickly they begin to work and how long they continue to control blood sugar. Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Using medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes. Insulin comes as a solution (liquid) and a suspension (liquid with particles that will settle on standing) to be injected subcutaneousl Continue reading >>

Humulin 30/70/humulin N/humulin R Presentation / Storage

Humulin 30/70/humulin N/humulin R Presentation / Storage

Humulin R, Humulin N, Humulin 30/70 vial: HUMULIN R: A sterile, clear colorless, aqueous solution of human insulin (DNA) adjusted to a pH of 7.0 to 7.8. Contains m-Cresol 0.25% added during manufacture as a preservative. HUMULIN N: A sterile suspension of a white, crystalline precipitate of isophane human insulin (DNA) in an isotonic phosphate buffer adjusted to a pH of 6.9 to 7.5. Contains m-Cresol 0.16% and phenol 0.065% added during manufacture as a preservative. HUMULIN 30/70: A sterile suspension of human insulin in the proportion of 30% soluble insulin and 70% isophane insulin. Contains m-Cresol 0.16% and phenol 0.065% added during manufacture as a preservative. Humulin R, Humulin N, Humulin 30/70 cartridge: 1 ml contains 100 IU human insulin (produced in E. coli by recombinant DNA technology). Humulin N: One cartridge contains 3 ml equivalent to 300 IU of isophane insulin. Humulin 30/70: One cartridge contains 3 ml equivalent to 300 IU of biphasic isophane insulin - 30 % soluble insulin/70 % isophane insulin. Humulin R: One cartridge contains 3 ml equivalent to 300 IU of soluble insulin. Humulin N: A suspension for injection in a cartridge. Humulin N is a sterile suspension of a white, crystalline precipitate of isophane human insulin in an isotonic phosphate buffer. Humulin 30/70: A suspension for injection in a cartridge. Humulin 30/70 is a sterile suspension of human insulin in the proportion of 30 % soluble insulin to 70 % isophane insulin. Humulin R: A solution for injection in a cartridge. Humulin R is a sterile, clear, colourless, aqueous solution of human insulin. Excipients/Inactive Ingredients: Humulin R, Humulin N, Humulin 30/70 vial: Humulin N or Humulin 30/70: m-cresol, glycerol, phenol, protamine sulphate,, dibasic sodium phosphate 7H2O, zinc oxide Continue reading >>

Humulin R Regular U-100 Insuln

Humulin R Regular U-100 Insuln

Overview How to use Side effects Precautions Storage Drug interactions Overdose More Insulin regular is used with a proper diet and exercise program to control high blood sugar in people with diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. This man-made insulin product is the same as human insulin. It replaces the insulin that your body would normally make. It is a short-acting insulin. It works by helping blood sugar (glucose) get into cells so your body can use it for energy. This medication is usually used in combination with a medium- or long-acting insulin product. This medication may also be used alone or with other oral diabetes drugs (such as metformin). Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor, diabetes educator, or pharmacist. Learn all preparation and usage instructions from your health care professional and the product package. Before using, check this product visually for particles or discoloration. If either is present, do not use the insulin. Insulin regular should be clear and colorless. Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin and to avoid developing problems under the skin (lipodystrophy). Insulin regular may be injected in the stomach area, the thigh, the buttocks, or the back of the upper arm. Do not inject into a vein or muscle because very low blood sugar (hypoglycemia) may occur. Do not rub the area after the injection. Do not inject into s Continue reading >>

Insulin

Insulin

insulin [in´su-lin] 1. the major fuel-regulating hormone of the body, a double-chain protein formed from proinsulin in the beta cells of the islets of Langerhans in the pancreas. Insulin promotes the storage of glucose and the uptake of amino acids, increases protein and lipid synthesis, and inhibits lipolysis and gluconeogenesis. Secretion of insulin is a response of the beta cells to a stimulus; the primary stimulus is glucose, and others are amino acids and hormones such as secretin, pancreozymin, and gastrin. These chemicals play an important role in maintaining normal blood glucose levels by triggering insulin release after a meal. After insulin is released from the beta cells, it enters the blood stream and is transported to cells throughout the body. The cell membranes have insulin receptors to which the hormone becomes bonded or “fixed.” An interaction between the insulin and its receptors leads to biochemical processes that include (1) the transport of glucose, amino acids, and certain ions across the membrane and into the cell body; (2) the storage of glycogen in liver and muscle cells; (3) the synthesis of triglycerides and storage of fat; (4) the synthesis of protein, RNA, and DNA, and (5) inhibition of gluconeogenesis, degradation of glycogen and protein, and lipolysis. Although insulin increases the transport of glucose across the cell membrane of most cells, in the brain glucose enters the cells by simple diffusion through the blood--brain barrier. 2. a preparation of the hormone, first discovered in 1921, used in treatment of diabetes mellitus; it may be bovine or porcine in origin (prepared from the pancreas of the animals) or a recombinant human type, although insulin of bovine origin is no longer available in the United States. Recombinant human Continue reading >>

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