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Humulin R Storage

Humulin R

Humulin R

HUMULIN®R (regular insulin human) Injection, USP (rDNA Origin) 100 Units per ML (U-100) DESCRIPTION Humulin® R U-100 is a polypeptide hormone structurally identical to human insulin synthesized through rDNA technology in a special non-disease-producing laboratory strain of Escherichia coli bacteria. Humulin R (insulin human recombinant) U-100 has the empirical formula C257H383N65O77S6 and a molecular weight of 5808. Humulin R (insulin human recombinant) U-100 is a sterile, clear, aqueous, and colorless solution that contains human insulin (rDNA origin) 100 units/mL, glycerin 16 mg/mL and metacresol 2.5 mg/mL, endogenous zinc (approximately 0.015 mg/100 units) and water for injection. The pH is 7.0 to 7.8. Sodiumhydroxide and/or hydrochloric acid may be added during manufacture to adjust the pH. Adequate insulin dosage permits patients with diabetes to effectively utilize carbohydrates, proteins and fats. Regardless of dose strength, insulin enables carbohydrate metabolism to occur and thus to prevent the production of ketone bodies by the liver. Some patients develop severe insulin resistance such that daily doses of several hundred units of insulin or more are required. Continue reading >>

Humulin R

Humulin R

Generic Name: human insulin Dosage Form: injection, solution HUMULIN® R REGULAR INSULIN HUMAN INJECTION, USP (rDNA ORIGIN)100 UNITS PER ML (U-100) INFORMATION FOR THE PHYSICIAN HUMULIN® R REGULAR INSULIN HUMAN INJECTION, USP (rDNA ORIGIN) 100 UNITS PER ML (U-100) DESCRIPTION Humulin® R U-100 is a polypeptide hormone structurally identical to human insulin synthesized through rDNA technology in a special non-disease-producing laboratory strain of Escherichia coli bacteria. Humulin R U-100 has the empirical formula C257H383N65O77S6 and a molecular weight of 5808. Humulin R U-100 is a sterile, clear, aqueous, and colorless solution that contains human insulin (rDNA origin) 100 units/mL, glycerin 16 mg/mL and metacresol 2.5 mg/mL, endogenous zinc (approximately 0.015 mg/100 units) and water for injection. The pH is 7.0 to 7.8. Sodium hydroxide and/or hydrochloric acid may be added during manufacture to adjust the pH. Adequate insulin dosage permits patients with diabetes to effectively utilize carbohydrates, proteins and fats. Regardless of dose strength, insulin enables carbohydrate metabolism to occur and thus to prevent the production of ketone bodies by the liver. Some patients develop severe insulin resistance such that daily doses of several hundred units of insulin or more are required. CLINICAL PHARMACOLOGY Regulation of glucose metabolism is the primary activity of insulin. Insulin lowers blood glucose by stimulating peripheral glucose uptake by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulins inhibit lipolysis, proteolysis, and gluconeogenesis, and enhance protein synthesis and conversion of excess glucose into fat. Administered insulin, including Humulin R U-100, substitutes for inadequate endogenous insulin secretion and partial Continue reading >>

Humulin R (cartridge) Solution For Injection

Humulin R (cartridge) Solution For Injection

Humulin R (Cartridge) Solution for injection Humulin R (Cartridge) Solution for injection Humulin R (Cartridge) Solution for injection Consumer medicine information (CMI) leaflet Please read this leaflet carefully before you start using Humulin R (Cartridge) Solution for injection. This leaflet answers some common questions about HUMULIN. It does not contain all the available information. It does not take the place of talking with your doctor or pharmacist. The information in this leaflet was last updated on the date shown on the final page. More recent information on this medicine may be available. Make sure you speak to your pharmacist, nurse or doctor to obtain the most up to date information on this medicine. You can also download the most up to date leaflet from www.lilly.com.au. The updated leaflet may contain important information about HUMULIN and its use that you should be aware of. Your doctor has weighed the risks of you taking HUMULIN against the benefits they expect it will have for you. If you have any concerns about using this medicine, ask your doctor or pharmacist. HUMULIN is used to reduce high blood sugar (glucose) levels in patients with diabetes mellitus. Diabetes is a condition in which your pancreas does not produce enough insulin to control your blood sugar level. Extra insulin is therefore needed. There are two types of diabetes mellitus: Type 1 diabetes - also called juvenile onset diabetes. Type 2 diabetes - also called maturity onset diabetes. Patients with type 1 diabetes always require insulin to control their blood sugar levels. Some patients with type 2 diabetes may also require insulin after initial treatment with diet, exercise and tablets. HUMULIN is identical to the insulin produced by the pancreas. There are 3 different types of HUM Continue reading >>

Insulin Injection

Insulin Injection

Insulin injection is used to control blood sugar in people who have type 1 diabetes (condition in which the body does not make insulin and therefore cannot control the amount of sugar in the blood) or in people who have type 2 diabetes (condition in which the blood sugar is too high because the body does not produce or use insulin normally) that cannot be controlled with oral medications alone. Insulin injection is in a class of medications called hormones. Insulin injection is used to take the place of insulin that is normally produced by the body. It works by helping move sugar from the blood into other body tissues where it is used for energy. It also stops the liver from producing more sugar. All of the types of insulin that are available work in this way. The types of insulin differ only in how quickly they begin to work and how long they continue to control blood sugar. Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Using medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes. Insulin comes as a solution (liquid) and a suspension (liquid with particles that will settle on standing) to be injected subcutaneousl Continue reading >>

Humulin R Regular U-100 Insuln

Humulin R Regular U-100 Insuln

Overview How to use Side effects Precautions Storage Drug interactions Overdose More Insulin regular is used with a proper diet and exercise program to control high blood sugar in people with diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. This man-made insulin product is the same as human insulin. It replaces the insulin that your body would normally make. It is a short-acting insulin. It works by helping blood sugar (glucose) get into cells so your body can use it for energy. This medication is usually used in combination with a medium- or long-acting insulin product. This medication may also be used alone or with other oral diabetes drugs (such as metformin). Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor, diabetes educator, or pharmacist. Learn all preparation and usage instructions from your health care professional and the product package. Before using, check this product visually for particles or discoloration. If either is present, do not use the insulin. Insulin regular should be clear and colorless. Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin and to avoid developing problems under the skin (lipodystrophy). Insulin regular may be injected in the stomach area, the thigh, the buttocks, or the back of the upper arm. Do not inject into a vein or muscle because very low blood sugar (hypoglycemia) may occur. Do not rub the area after the injection. Do not inject into s Continue reading >>

Can Insulin Go Back In The Fridge?

Can Insulin Go Back In The Fridge?

After removing insulin glargine (Lantus) from the refrigerator for use, can it be refrigerated over and over again after having warmed to room temperature, or does this degrade it? Continue reading >>

Humulin R U-500 Kwikpen Now Available

Humulin R U-500 Kwikpen Now Available

Eli Lilly announced the launch of Humulin R U-500 KwikPen Eli Lilly announced the launch of Humulin R U-500 KwikPen (insulin human injection), a prefilled device containing a highly concentrated formulation of insulin. The Food and Drug Administration (FDA) approved Humulin R U-500 KwikPen in January 2016. It is a man-made insulin used to control high blood sugar in adults and children with type 1 and type 2 diabetes who require >200 units of insulin daily. The U-500 formulation is 5 times more concentrated than the standard U-100 insulin, allowing patients with diabetes to inject up to 80% less liquid while receiving the required dose. RELATED: Extreme Insulin Requirements in Patient with Rare Genetic Disorder Insulins lower blood glucose by stimulating peripheral glucose uptake by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulins inhibit lipolysis and proteolysis, and enhance protein synthesis. The Humulin R U-500 is now available as 3mL KwikPens in 2- and 5-count cartons and as 20mL vials. For more information call (800) 545-5979 or visit Humulin.com . Continue reading >>

Humulin R Price Comparison: Uses, Dosage, Form & Side Effects

Humulin R Price Comparison: Uses, Dosage, Form & Side Effects

It is very important to know about what medicine is given by the doctor, for what condition, and when it needs to be taken in what dose. This information given by the doctor is called Prescription. The patients should be familiar with the medicine prescription, and the details about the medicine before purchasing it and using it. Some medications need not be prescribed by healthcare practitioners and can be purchased and used without prescription by the patients; these are called over-the-counter medications. Read the drug prescription information of Humulin R before taking it. Humulin is synthesized in a special non-disease-producing laboratory strain of Escherichia coli bacteria that has been genetically altered by the addition of the gene for human insulin production. HumulinR(U-500) consists of zinc-insulin crystals dissolved in a clear fluid. HumulinR(U-500) is a sterile solution and is for subcutaneous injection. It should not be used intravenously or intramuscularly. The concentration of HumulinR(U-500) is 500units/mL.Each milliliter contains 500units of biosynthetic human insulin, 16mg glycerin, 2.5mgMetacresol as a preservative, and zinc-oxide calculated to supplement endogenous zinc to obtain a total zinc content of 0.017mg/100units. Sodium hydroxide and/or hydrochloric acid may be added during manufacture to adjust the pH. Humulin R (insulin human SUBCUTANEOUS) is indicated for the following: HumulinR(U-500) is especially useful for the treatment of diabetic patients with marked insulin resistance (daily requirements more than 200units), since a large dose may be administered subcutaneously in a reasonable volume. Humulin R is a form of insulin usually used to treat diabetes. Some of the most prescribed drugs in this class include: Lantus; Humalog; Novolog; Continue reading >>

How Long Should Insulin Be Used Once A Vial Is Started?

How Long Should Insulin Be Used Once A Vial Is Started?

Editor’s comment: The commentary by Dr. Grajower has such important clinical relevance that responses were invited from the three pharmaceutical companies that supply insulin in the U.S. and the American Diabetes Association, and all of these combined in this commentary. The commenting letter and individual responses were authored separately and are completely independent of each other. Diabetic patients treated with insulin, whether for type 1 or type 2 diabetes, are prone to often unexplained swings in their blood glucose. These swings can vary from dangerously low to persistently high levels. Most diabetic patients, and most physicians, will adjust insulin regimens so as to avoid hypoglycemia at the expense of hyperglycemia. Among the “textbook” reasons for variable glucose responses to any given insulin regimen are 1) site of administration, 2) exercise, 3) bottles not adequately mixed before drawing the insulin (for NPH, Lente, or Ultralente), and 4) duration of treatment with insulin (1). A new insulin was marketed by Aventis Pharmaceuticals about 1 year ago, insulin glargine (Lantus). The manufacturer seemed to stress that patients not use a started bottle of this insulin for >28 days (2). Two patients of mine highlighted this point. L.K. is a 76-year-old woman with type 2 diabetes, diagnosed at 55 years of age, and treated with insulin since age 56. Her insulin regimen was changed to Lantus at night together with Novolog before meals. She monitors her blood glucose four times a day. She used a bottle of Lantus until it ran out; therefore, a bottle lasted for 2 months. Her recent HbA1c was 7.6%. I retrospectively analyzed her home glucose readings by averaging her fasting blood glucose levels for the first 15 days of a new bottle and the last 15 days of tha Continue reading >>

Humulin R U-500 Vial

Humulin R U-500 Vial

Uses Concentrated insulin regular is used with a proper diet and exercise program to control high blood sugar in people with diabetes who require large doses of insulin (more than 200 units per day). Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. This man-made insulin product is the same as human insulin. It replaces the insulin that your body would normally make. It works right away like regular insulin but its effects last longer. It works by helping blood sugar (glucose) get into cells so your body can use it for energy. This medication may be used alone or with other oral diabetes drugs (such as metformin). How to use Humulin R U-500 Vial Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor, diabetes educator, or pharmacist. This insulin product is a high-strength concentrated liquid. Learn all preparation and usage instructions from your health care professional and the product package. If you are using the vial, use the proper syringe prescribed by your doctor to make sure you are measuring the correct dose. Before using, check this product visually for particles or discoloration. If either is present, do not use the insulin. This insulin product should be clear and colorless. Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin and to avoid developing problems under the skin (lipodystrophy). This insulin product may be injected in the stomach area, the thigh, the buttocks, or the back of t Continue reading >>

Humulin 30/70/humulin N/humulin R Presentation / Storage

Humulin 30/70/humulin N/humulin R Presentation / Storage

Humulin R, Humulin N, Humulin 30/70 vial: HUMULIN R: A sterile, clear colorless, aqueous solution of human insulin (DNA) adjusted to a pH of 7.0 to 7.8. Contains m-Cresol 0.25% added during manufacture as a preservative. HUMULIN N: A sterile suspension of a white, crystalline precipitate of isophane human insulin (DNA) in an isotonic phosphate buffer adjusted to a pH of 6.9 to 7.5. Contains m-Cresol 0.16% and phenol 0.065% added during manufacture as a preservative. HUMULIN 30/70: A sterile suspension of human insulin in the proportion of 30% soluble insulin and 70% isophane insulin. Contains m-Cresol 0.16% and phenol 0.065% added during manufacture as a preservative. Humulin R, Humulin N, Humulin 30/70 cartridge: 1 ml contains 100 IU human insulin (produced in E. coli by recombinant DNA technology). Humulin N: One cartridge contains 3 ml equivalent to 300 IU of isophane insulin. Humulin 30/70: One cartridge contains 3 ml equivalent to 300 IU of biphasic isophane insulin - 30 % soluble insulin/70 % isophane insulin. Humulin R: One cartridge contains 3 ml equivalent to 300 IU of soluble insulin. Humulin N: A suspension for injection in a cartridge. Humulin N is a sterile suspension of a white, crystalline precipitate of isophane human insulin in an isotonic phosphate buffer. Humulin 30/70: A suspension for injection in a cartridge. Humulin 30/70 is a sterile suspension of human insulin in the proportion of 30 % soluble insulin to 70 % isophane insulin. Humulin R: A solution for injection in a cartridge. Humulin R is a sterile, clear, colourless, aqueous solution of human insulin. Excipients/Inactive Ingredients: Humulin R, Humulin N, Humulin 30/70 vial: Humulin N or Humulin 30/70: m-cresol, glycerol, phenol, protamine sulphate,, dibasic sodium phosphate 7H2O, zinc oxide Continue reading >>

Ptce Quiz 6 Review

Ptce Quiz 6 Review

How many days will it take a patient injecting 23 units of Humulin R insulin daily to complete a 10 ml vial? A. 30 days B. 23 days C. 43 days D. 14 days C. 43 days Which size needle and syringe would a very thin patient use if injecting 23 units of insulin daily? A. 1cc short 25 gauge B. 1/3 cc short 30 gauge C. ½ cc long 30 gauge D. 1/3 cc long 25 gauge B. 1/3 cc short 30 gauge Glucagon is used: A. When a patient has high blood sugar (hyperglycemia) B. As a substitute for sugar in their diets. C. When a patient has low blood sugar (hypoglycemia) D. daily with insulin injections to prevent hypoglycemia. C. For low blood sugar Type 1 diabetics would not use which medication? A. Lantus B. Glucagon C. Glucotrol D. Lispro C. Glucotrol Which insulin is cloudy? A. Humulin R B. Humulin N C. Lantus D. All the drugs listed are cloudy B. Humulin N Which statement is true regarding insulin and refrigeration? A. Insulin should never be refrigerated. B. Insulin should never be left outside of the refrigerator. C. Insulin is good for approximately 28 days outside of refrigeration. D. Insulin burns more when injected at room temperature. C. Which statement is true regarding Type 2 diabetes? A. Usually diagnosed during pregnancy. B. Only use insulin. C. Can use both insulin and oral medications. D. All of the answers are correct. C. Can use both insulin and oral medications. Type 1 diabetics can increase their pancreatic output of insulin by changing their diet and exercise. A. True B. False B. False Which insulin comes in an inhalation dosage form? A. Exubera B. Lantus C. Humalog D. Humulin 70/30 mix A. Exubera Which insulin can be given IV? A. Humulin R B. Humulin N C. Lantus D. Humalog mix 75/25 A. Humulin R What is the proper temperature for insulin storage? A. 10-20 degrees Fah Continue reading >>

The Abcs Of Insulin

The Abcs Of Insulin

Insulin is a naturally occurring hormone produced by the pancreas. Insulin is required to move sugar from the blood into the bodys cells, where it can be used for energy. For the symptoms of high blood sugar and low blood sugar, see Tables 1 and 2. Type 1 diabetes (T1D) is a chronic condition in which the pancreas produces little or no insulin. Only 5% of patients with diabetes have this form of the disease, according to the American Diabetes Association. Type 2 diabetes (T2D) is much more common; the risk factors are listed in online table 3. Individuals with T2D make insulin, but their bodies dont respond well to it, a condition known as insulin resistance. Treatment of T2D usually begins with dietary and lifestyle changes, as well as oral medications. Over time, as the pancreas struggles to make an adequate amount of insulin to overcome insulin resistance, patients may require insulin supplementation. Insulin therapy must be individualized and balanced with meal planning and exercise. When a patient begins using insulin to manage diabetes, the initial dose is just a starting point. Over time, insulin requirements are affected by factors such as weight gain or loss, changes in eating habits, and the addition of other medications. The need for insulin often increases, and the dose must be readjusted to meet the new requirements. Insulin is injected subcutaneously, meaning not very deep under the skin. Common injection sites include the stomach, buttocks, thighs, and upper arms. By rotating the site of injection, patients can avoid lipohypertrophy, a slight increase in the growth or size of fat cells under the skin. When lipohypertrophy occurs, a soft pillowy growth may form at the repeated-use injection site. Therefore, for reliable absorption rates and cosmetic purpo Continue reading >>

U-500 Insulin: Not For Ordinary Use

U-500 Insulin: Not For Ordinary Use

US Pharm. 2010;35(5)(Diabetes suppl):14-17. If not already seeing them, pharmacists should anticipate encountering prescriptions for U-500 regular insulin. U-500 insulin is five times more potent than standard U-100 and is utilized in patients requiring high doses of insulin. Prescribing of U-500 is on the rise due to the obesity epidemic, adoption of tighter glucose control protocols, increased insulin resistance, and utilization of insulin pumps.1 Potential for adverse drug events exists due to unfamiliarity with U-500 and its higher potency. This review is intended to enable safe provision of U-500 insulin by increasing awareness of the drug and its correct administration. As insulin resistance worsens, greater doses of insulin are required to meet glycemic goals. This is especially true for persons with insulin resistance (IR) syndromes. These are patients with an insulin requirement of 200 U/day and greater. FIGURE 1 illustrates the body’s response to insulin as the dose increases. Note that for patients with IR syndromes, the dose response to insulin is significantly diminished. This is especially true when insulin doses exceed 100 U. However, this phenomenon does not mean greater doses are without effect.2 In fact, higher doses of insulin eventually achieve therapeutic targets. For this reason, use of high-dose insulin should not be avoided in insulin-resistant patients. Otherwise, these patients will fail to achieve glycemic goals by underdosing insulin. Use of standard insulin becomes problematic when patients require over 200 U/day or greater than 100 U per injection. At these doses, the volume of U-100 insulin is physically too large for single subcutaneous administration, and multiple injections are required to deliver a single dose. With more injections, Continue reading >>

Indication For Humulin R U-500

Indication For Humulin R U-500

If your A1C is uncontrolled on high doses of standard insulin—more than 200 units a day—you may have another diabetes treatment option. Humulin® R U-500 is 5x concentrated insulin* available in a U-500 KwikPen® or syringe and vial. U-500 lowered high blood sugar in a clinical study. † If your doctor has prescribed U-500 for you or a loved one, learn more here. † 24 week, open-label, randomized trial to compare the efficacy and safety of 2 dosing regiments (TID, n=162 vs BID, n=163) for U-500 insulin replacing high dose U-100 insulin (>200 units per day) with or without oral antihyperglycemic drugs in adult patients with uncontrolled type 2 diabetes. These regimens were found to be equivalent for A1C reduction over 24 weeks, and both were efficacious. Study conducted with U-100 insulin syringes and Humulin R U-500 vials. Continue reading >>

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