Humulin R U-500 (concentrated) Insulin Kwikpen Subcutaneous : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - Webmd
Concentrated insulin regular is used with a proper diet and exercise program to control high blood sugar in people with diabetes who require large doses of insulin (more than 200 units per day). Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke . This man-made insulin product is the same as human insulin . It replaces the insulin that your body would normally make. It works right away like regular insulin but its effects last longer. It works by helping blood sugar ( glucose ) get into cells so your body can use it for energy. This medication may be used alone or with other oral diabetes drugs (such as metformin ). How to use Humulin R U-500 Kwikpen Insulin Pen Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor, diabetes educator, or pharmacist. This insulin product is a high-strength concentrated liquid. Learn all preparation and usage instructions from your health care professional and the product package. If you are using the vial, use the proper syringe prescribed by your doctor to make sure you are measuring the correct dose. Before using, check this product visually for particles or discoloration. If either is present, do not use the insulin . This insulin product should be clear and colorless. Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin and to avoid developing problems under the skin ( lipodystrophy ). This insulin product may be injected in the stomach area, the thigh, the buttock Continue reading >>
Humulin R Kwikpen (concentrated) (u-500)
Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Concentrated (U-500) insulin is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. U-500 insulin is five times more concentrated than regular U-100 insulin. U-500 insulin is used to improve blood sugar control in adults and children with diabetes mellitus who have significant daily insulin needs (more than 200 units per day). U-500 insulin may also be used for purposes not listed in this medication guide. Never share an injection pen, cartridge, or syringe with another person, even if the needle has been changed. You should not use this medicine if you are allergic to insulin, or if you are having an episode of hypoglycemia ( low blood sugar ). To make sure U-500 insulin is safe for you, tell your doctor if you have: low levels of potassium in your blood ( hypokalemia ). Tell your doctor if you also take pioglitazone or rosiglitazone (sometimes contained in combinations with glimepiride or metformin ). Taking certain oral diabetes medicines while you are using insulin may increase your risk of serious heart problems. Follow your doctor's instructions about using insulin if you are pregnant or breast-feeding a baby. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester of pregnancy. Your dose needs may also be different while you are breast-feeding. U-500 insulin is concentrated and contains 500 units of insulin in each milliliter (mL). This is five times more concentrated than regular U-100 insulin, which contains 100 units per mL. Measure each dose of U-500 insulin carefully. Using too much insulin can lead to insulin shock or death. Follow all directions on your pre Continue reading >>
Humulin R (cartridge) Solution For Injection
Humulin R (Cartridge) Solution for injection Humulin R (Cartridge) Solution for injection Humulin R (Cartridge) Solution for injection Consumer medicine information (CMI) leaflet Please read this leaflet carefully before you start using Humulin R (Cartridge) Solution for injection. This leaflet answers some common questions about HUMULIN. It does not contain all the available information. It does not take the place of talking with your doctor or pharmacist. The information in this leaflet was last updated on the date shown on the final page. More recent information on this medicine may be available. Make sure you speak to your pharmacist, nurse or doctor to obtain the most up to date information on this medicine. You can also download the most up to date leaflet from www.lilly.com.au. The updated leaflet may contain important information about HUMULIN and its use that you should be aware of. Your doctor has weighed the risks of you taking HUMULIN against the benefits they expect it will have for you. If you have any concerns about using this medicine, ask your doctor or pharmacist. HUMULIN is used to reduce high blood sugar (glucose) levels in patients with diabetes mellitus. Diabetes is a condition in which your pancreas does not produce enough insulin to control your blood sugar level. Extra insulin is therefore needed. There are two types of diabetes mellitus: Type 1 diabetes - also called juvenile onset diabetes. Type 2 diabetes - also called maturity onset diabetes. Patients with type 1 diabetes always require insulin to control their blood sugar levels. Some patients with type 2 diabetes may also require insulin after initial treatment with diet, exercise and tablets. HUMULIN is identical to the insulin produced by the pancreas. There are 3 different types of HUM Continue reading >>
Indication For Humulin R U-500
What is the most important information I should know about Humulin R U-500? Do not share your Humulin R U-500 KwikPen or U-500 insulin syringes with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them. Do not take Humulin R U-500 if your blood sugar is too low (hypoglycemia) or you are allergic to any of the ingredients in Humulin R U-500. Tell your healthcare provider: If you have liver, kidney, or heart problems or any other medical conditions. If you are pregnant, plan to become pregnant, or are breast-feeding. About all the medicines you take, including prescription (especially ones commonly called TZDs [thiazolidinediones]) and over the counter medicines, vitamins, and herbal supplements. Before you start using Humulin R U-500, talk to your healthcare provider about low blood sugar and how to manage it. Take Humulin R U-500 exactly as your healthcare provider tells you to. Your healthcare provider should show you how much Humulin R U-500 to use and when to use it. Check your insulin label each time you give your injection to make sure you are using the correct insulin. Humulin R U-500 KwikPen: The U-500 KwikPen is specially made to dial and deliver doses of Humulin R U-500 insulin. Do not use any syringe to remove Humulin R U-500 insulin from your U-500 KwikPen. The markings on certain syringes will not measure your dose correctly. A severe overdose can happen, causing low blood sugar, which may put your life in danger. Humulin R U-500 vial: There is a special U-500 insulin syringe to measure Humulin R U-500. Use only a U-500 insulin syringe to draw up and inject your Humulin R U-500. If you do not use the right syringe type, you may take the wrong dose of Humulin R U-500. This can ca Continue reading >>
Insulin Regular Human (rx, Otc)
Dosage Forms & Strengths injectable solution Type 1 Diabetes Mellitus Initial: 0.2-0.4 units/kg/day SC divided q8hr or more frequently Maintenance: 0.5-1 unit/kg/day SC divided q8hr or more frequently; in insulin-resistant patients (eg, due to obesity), substantially higher daily insulin may be required Approximately 50-75% of the total daily insulin requirements are given as intermediate- or long-acting insulin administered in 1-2 injections; rapid- or short-acting insulin should be used before or at mealtimes to satisfy the remainder balance of the total daily insulin requirements Premixed combinations are available that deliver rapid- or short-acting components at the same time as the intermediate- or long-acting component Type 2 Diabetes Mellitus Type 2 diabetes inadequately controlled by diet, exercise, or oral medication: Suggested beginning dose of 10 units/day SC (or 0.1-0.2 unit/kg/day) in evening or divided q12hr Severe Hyperglycemia (Diabetic Ketoacidosis) 0.1 unit/kg/hr IV continuous infusion; if serum glucose does not fall by 50 mg/dL in the first hour, check hydration status; if possible, double the insulin hourly until glucose levels fall at the rate of 50-75 mg/dL/hr; decrease infusion to 0.05-0.1 unit/kg/hour when blood sugar reaches 250 mg/dL Dosing Considerations Dosage of human insulin, which is always expressed in USP units, must be based on the results of blood and urine glucose tests and must be carefully individualized to optimal effect Dose adjustments should be based on regular blood glucose testing Adjust to achieve appropriate glucose control Look for consistent pattern in blood sugars for >3 days Same time each day: Compare blood glucose levels with previous levels found at that time of day For each time of day: Calculate blood glucose range Continue reading >>
March 2018 - When Will The Humulin R Pen Patents Expire, And When Will Generic Humulin R Pen Launch?
For more informationtry a trial or see the plans and pricing Serving hundreds of leading biopharmaceutical companies globally: Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors.Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data.The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free.thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user.Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. Continue reading >>
U.s. Food And Drug Administration Approves Humulin® R U-500 Kwikpen®
INDIANAPOLIS, Jan. 21, 2016 /PRNewswire/ -- The U.S. Food and Drug Administration (FDA) has approved Eli Lilly and Company's (NYSE: LLY) Humulin® R U-500 KwikPen®(insulin human injection) 500 units/mL, a pre-filled device containing Humulin R U-500, a highly concentrated formulation of insulin. Humulin R U-500 is the only FDA-approved insulin that is five-times more concentrated than standard U-100 insulin. This insulin is used to treat high blood sugar in people with type 1 and type 2 diabetes who need more than 200 units of insulin per day. The safety and efficacy of Humulin R U-500 used in combination with other insulins or delivered by an insulin infusion pump has not been determined. "People with diabetes and severe insulin resistance who have become poorly responsive to the effects of insulin may require much higher insulin doses – more than 200 units per day – to help keep their blood sugar levels on target," said Jeffrey A. Jackson, MD, FACE, CDE, Medical Fellow, US Medical Affairs, Lilly Diabetes. "For these patients, the U-500 KwikPen is now available as a convenient alternate option to deliver a large dose of insulin in a reasonable volume. It was specifically designed as a dedicated dosing device to eliminate the need for dose conversion, as compared to use of the vial and syringe options, which some people may find to be an improvement." Until now, Humulin R U-500 was only available in a vial, administered with either a U-100 insulin syringe or a volumetric (tuberculin) syringe that requires conversion to respective syringe "unit markings" or volume markings. Although each U-500 KwikPen holds 1500 units of insulin (the amount in five U-100 insulin pens), it is the same size as other KwikPens and dials in five-unit increments. The U-500 KwikPen has a u Continue reading >>
Humulin R Versus Humalog: A Side-by-side Comparison
Diabetes is a disease that causes high blood sugar levels. Left untreated, high blood sugar levels can cause many problems, such as heart and blood vessel disease, stroke, kidney failure, and blindness. Humulin R and Humalog are two different types of insulin that can help lower your blood sugar level. These drugs work in slightly different ways. In general, insulin lowers your blood sugar level by signaling to your muscle and fat cells to use sugar from your blood. It also signals your liver to stop making sugar. Depending on the type and severity of your diabetes, you may need to take insulin. We’ll compare and contrast Humulin R and Humalog to help you decide if one may be a good choice to treat your diabetes. Humulin R is a brand name for regular insulin. It is a short-acting insulin. That means that it takes about 30 minutes to reach your bloodstream and works for about three to six hours. Humalog is a brand name for insulin lispro, which is a fast-acting insulin. It takes about 15 minutes to start working, but it only lasts two to four hours. The following table compares more features of these two drugs. Humulin R Humalog What drug is it? Regular insulin (short-acting insulin) Insulin lispro (fast-acting insulin) What’s it used for? Blood sugar control in people with diabetes Blood sugar control in people with diabetes Do I need a prescription to buy this drug? No Yes Is a generic version available? No No What forms does it come in? Injectable solution, available in a vial for use with a syringe Injectable solution, available in a vial for use with a syringe. Injectable solution, available in a cartridge that you use in a device called a KwikPen How much do I take? Your doctor will tell you what dose to inject. This depends on your blood sugar readings and the Continue reading >>
Humulin R U-500 Kwikpen Prescription Price Comparison | Compare Drug Prices | Scriptsave Wellrx
The entered address, city, state, or zip was not found. Please re-enter and try again. Please enter an address, city, state, or zip. Special characters not allowed in Drug Name field. Location information is unavailable Please enter your address, city, state, or zip in the field provided. The request to Geolocate timed out. Please enter your address, city, state, or zip in the field provided. An unknown error occurred. Please enter your address, city, state, or zip in the field provided. Compare Pharmacy Prescription Drug Prices ScriptSave WellRx is the smart and trusted resource that makes prescription medicines more affordable and easier to manage, because ScriptSave WellRx cares about helping people stay healthy. ScriptSave WellRx is free to join, and we're accepted nationwide at more than 62,000 pharmacies. Enter the prescription drugs you are searching for along with your address or zip code and compare pharmacy prices to find the best prescription drug prices in your area. You can also download our app and use its functionality on the go. How does the ScriptSave WellRx Card work? Simply present your ScriptSave WellRx card at any of the thousands of participating pharmacies nationwide to receive your instant savings. It's that easy! Just show your card to the pharmacist each time you pick up your prescription, whether you're filling for the first time or refilling. There is no paperwork to complete and no limit on usage. How much will I save with the ScriptSave WellRx card? Savings average 54%, and, in some cases, can be 80% or more.* Savings vary based upon the medication and the pharmacy you choose to use. Start saving big on all of your medicine needs with ScriptSave WellRx. Do all pharmacies accept the ScriptSave WellRx Card? ScriptSave WellRx is accepted at 6 Continue reading >>
Indication For Humulin R U-500
If your A1C is uncontrolled on high doses of standard insulin—more than 200 units a day—you may have another diabetes treatment option. Humulin® R U-500 is 5x concentrated insulin* available in a U-500 KwikPen® or syringe and vial. U-500 lowered high blood sugar in a clinical study. † If your doctor has prescribed U-500 for you or a loved one, learn more here. † 24 week, open-label, randomized trial to compare the efficacy and safety of 2 dosing regiments (TID, n=162 vs BID, n=163) for U-500 insulin replacing high dose U-100 insulin (>200 units per day) with or without oral antihyperglycemic drugs in adult patients with uncontrolled type 2 diabetes. These regimens were found to be equivalent for A1C reduction over 24 weeks, and both were efficacious. Study conducted with U-100 insulin syringes and Humulin R U-500 vials. Continue reading >>
Dailymed - Humulin R U-500 - Insulin Human Injection, Solution Humulin R U-500 Kwikpen - Insulin Human Injection, Solution
Do not share your HumulinR U-500 KwikPen or U-500 insulin syringes with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them. HumulinR U-500 is a man-made insulin that is used to control high blood sugar in adults and children with diabetes mellitus who need more than 200units of insulin in a day. HumulinR U-500 contains 5 times as much insulin (500units/mL) in 1mL as standard insulin (100units/mL). It is not known if Humulin R U-500 is safe and effective when used in combination with other insulins. It is not known if Humulin R U-500 is safe and effective when given by continuous subcutaneous infusion. It is not known if HumulinR U-500 is safe and effective in children. are having an episode of low blood sugar (hypoglycemia). have an allergy to human insulin or any of the ingredients in HumulinR U-500. See the end of this Patient Information leaflet for a complete list of ingredients in HumulinR U-500. What should I tell my healthcare provider before using HumulinR U-500? Before using HumulinR U-500, tell your healthcare provider about all your medical conditions including, if you: take other medicines, especially ones called TZDs (thiazolidinediones). have heart failure or other heart problems. If you have heart failure, it may get worse while you take TZDs with HumulinR U-500. are pregnant, planning to become pregnant, or breast-feeding. It is not known if HumulinR U-500 will harm your unborn or breastfeeding baby. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, or herbal supplements. Before you start using HumulinR U-500, talk to your healthcare provider about low blood sugar and how to manage it. Read the Continue reading >>
Diabetes Medicine: Humulin-râ® U-500 Insulin
F A C T S H E E T F O R P A T I E N T S A N D F A M I L I E SF A C T S H E E T F O R P A T I E N T S A N D F A M I L I E S What is insulin, and what does it do? Insulin is a medicine used to treat diabetes. It is given by injection (shot). It moves glucose (sugar) out of your blood and into your body’s cells. Insulin helps lower your blood glucose and makes it less likely that your diabetes will cause serious problems. What is U-500 insulin? U-500 helps control blood glucose for 8 to 24 hours. This type of insulin is only used if you need more than 200 units of insulin per day. U-500 insulin is 5 times stronger than standard U-100 insulin. When do I give U-500 insulin? U-500 starts working about 30 minutes after it is given. You will likely need to give yourself a dose 2 or 3 times per day before meals. To prevent low blood glucose (hypoglycemia), you should always eat within 30 minutes of giving U-500 insulin. How do I give U-500 insulin? U-500 can be injected with a syringe or a pen. • Inject insulin into the fatty tissue just under the skin, NOT the muscle. • The best areas to inject insulin are the belly, the top and outside of your thighs, or the back of your upper arms. • Change injection sites within those areas each time you give a dose. Do not inject in the same site every day. See the back of this sheet to learn how to give U-500 insulin with a syringe or a pen. General guidelines for taking insulin Here are some general rules to help you use insulin safely: • Try to eat your meals and snacks at the same time every day. Stick to a regular schedule for breakfast, lunch, dinner, and bedtime snacks. This will help your insulin work better and keep your blood glucose at the right level. • Don’t stop taking your ins Continue reading >>
Fda Approves First U-500 Insulin Pen
(Humulin(R) R U-500 KwikPen(R) (PRNewsFoto/Eli Lilly and Company)) On January 21, 2016, the U.S. Food and Drug Administration (FDA) approved the Humulin R U-500 KwikPen (insulin human injection) 500 units/ml for people with Type 1 and Type 2 diabetes who need more than 200 units of insulin per day. The device, which is manufactured by pharmaceutical company Eli Lilly and Company, is the first insulin pen to be approved for delivering U-500 insulin. U-500 insulin is five times as concentrated as standard U-100 insulin, and is generally used to treat people who have severe insulin resistance. Larger volumes of insulin are absorbed less predictably and therefore have less predictable effects on blood sugar levels. Because a dose of U-500 insulin takes only one-fifth the volume of the same dose of U-100 insulin, this variability is reduced. Until this approval, Humulin R U-500 has only been available in a vial, administered either through a U-100 or TB syringe and requiring conversion to the syringe unit markings. This new prefilled pen is specifically designed for U-500 insulin, potentially helping to prevent dosing errors. The device is the same size as other KwikPens (in an aqua color), but it dials in 5-unit increments and holds 1,500 units of insulin — the amount contained in five U-100 insulin pens. Unopened pens should be kept in the refrigerator, and in-use pens should be kept at room temperature. Once open, Humulin R U-500 KwikPens should be thrown out after 28 days, even if insulin remains. The pen is expected to hit the market in April 2016. According to Eli Lilly, “the Humulin R U-500 Savings Card Program offers eligible, commercially insured patients the opportunity to pay as little as $25 per prescription for up to 12 redemptions over a 12-month period.” Continue reading >>
Learning About Humulin R U-500 Insulin (500 Units/ml) Kwikpen®
Traditional insulin is available in a concentration of 100units/ml and is called U100 insulin. Anything greater then 100units/ml is considered “concentrated” insulin. Humulin R U500 insulin is 5 times more concentrated than U100 insulin. It is used in patients that are insulin resistant usually requiring greater than 200 units of insulin per day. Although Humulin R U500 has been available since 1994, until 2016 it was only available in a vial and needed to be administered with a syringe. It is now available in an insulin pen called the Kwikpen®. To read about uses of U500 insulin in the vial see The vial use was associated with some difficulties for patients and providers alike. There are no insulin syringes made specifically for U500 concentrated insulin. Therefore, a U100 insulin syringe was sometimes used and dosing calculations needed to be done. Alternatively, a tuberculin syringe could be used and the insulin dosed in volume (milliliters). Both options were complicated and there was a very high risk of dosing errors. The availability of a pen eliminates these potential critical errors. To use the pen, you place a short pen needle on the end of the pen and dial the number of units needed. A needle as short as 4mm in length can be used. This Kwikpen can be injected into the stomach, buttocks, upper legs, and upper arms. It dials in 5unit increments. It can dial up to 300 units per injection. It holds 1500 units of insulin per pen. Be sure to rotate the injection site with each injection. The color of the pen was strategically planned to be aqua-colored in order for it to be easily differentiated from the other insulin pens. The Humulin R U-500 Kwikpen should be taken 30 minutes before eating and stored in a refrigerator until it is used. Once opened, it should Continue reading >>
Compound Report Card
EBI Databases Small Molecules ChEMBL Database CHEMBL1201631 Compound Name and Classification ChEMBL Synonyms NOVOLIN R | EXUBERA | INSULIN HUMAN | INSULIN (HUMAN) | VELOSULIN BR | VELOSULIN BR HUMAN | INSULIN | HUMULIN | INSULIN RECOMBINANT PURIFIED HUMAN | INSULIN HUMAN (BIOSYNTHESIS) | HUMULIN R PEN | VELOSULIN | NOVOLIN | INSULIN RECOMBINANT HUMAN | HUMULIN R | HUMULIN BR | INSULIN HUMAN (SYNTHESIS) Trade Names EXUBERA | HUMULIN BR | HUMULIN R | NOVOLIN | VELOSULIN | HUMULIN R PEN | HUMULIN | VELOSULIN BR HUMAN | NOVOLIN R | VELOSULIN BR Sources British National Formulary DrugMatrix Orange Book Scientific Literature TP-search Transporter Database USP Dictionary of USAN and International Drug Names WHO Anatomical Therapeutic Chemical Classification Molecule Features Mechanism of Action Indications MESH Heading MESH ID EFO ID EFO Term Max phase for indication References DIABETES MELLITUS, TYPE 2 D003924 EFO:0001360 TYPE II DIABETES MELLITUS 4 ClinicalTrials ClinicalTrials DailyMed DIABETES MELLITUS D003920 EFO:0000400 DIABETES MELLITUS 4 ClinicalTrials ClinicalTrials ATC ATC ATC HYPERGLYCEMIA D006943 HP:0003074 HYPERGLYCEMIA 4 ClinicalTrials ClinicalTrials ClinicalTrials DIABETES MELLITUS, TYPE 1 D003922 EFO:0001359 TYPE I DIABETES MELLITUS 3 ClinicalTrials ClinicalTrials DEPRESSIVE DISORDER D003866 EFO:0003761 UNIPOLAR DEPRESSION 3 ClinicalTrials LIPID METABOLISM DISORDERS D052439 Orphanet:309005 DISORDER OF LIPID METABOLISM 3 ClinicalTrials BIPOLAR DISORDER D001714 EFO:0000289 BIPOLAR DISORDER 3 ClinicalTrials DIABETES, GESTATIONAL D016640 EFO:0004593 GESTATIONAL DIABETES 3 ClinicalTrials ClinicalTrials DIABETIC NEUROPATHIES D003929 EFO:1000783 DIABETIC NEUROPATHY 2 ClinicalTrials NON-ALCOHOLIC FATTY LIVER DISEASE D065626 EFO:0003095 NON-ALCOHOLIC FATTY LIVER DISEASE Continue reading >>
