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Humulin R Monograph

Humulin R Entire Monograph - Epocrates Online

Humulin R Entire Monograph - Epocrates Online

Dose: individualize dose SC bid-qid; Info: usual total daily insulin requirement 0.5-1 units/kg/day (basal + prandial); give 30min before meals or per sliding scale; onset 0.5-1h, peak 2-4h, duration 6-12h (short-acting insulin) Dose: individualize dose SC bid-qid; Info: for pts requiring >200 units/day; usual total daily insulin requirement 0.5-1 units/kg/day (basal + prandial); give 30min before meals or per sliding scale; onset 0.5-1h, peak 2-4h, duration up to 24h (short to intermediate-acting insulin) Dose: 0.1 units/kg IV x1, then 0.1 units/kg/h IV; Alt: 0.14 units/kg/h IV; Info: if blood glucose decr. by <10% in 1st hour, give 0.14 units/kg IV x1, then resume usual dose; when blood glucose 200 mg/dL, decr. dose to 0.02-0.05 units/kg/h IV; maintain blood glucose at 150-200 mg/dL until DKA resolves CrCl 10-50: decr. dose 25%; CrCl <10: decr. dose 50%; HD/PD: no supplement hepatic impairment: decr. dose, amount not defined Dosage forms: INJ (U-100 vial): 100 units per mL; INJ (U-500 vial): 500 units per mL; INJ (U-500 pen): 500 units per mL Dose: individualize dose SC bid-qid; Info: usual total insulin requirement 0.5-1 units/kg/day; adolescents may require higher doses; give 30min before meals or per sliding scale; onset 0.5-1h, peak 2-4h, duration 6-12h (short-acting insulin) Dose: individualize dose SC bid-qid; Info: for pts requiring >200 units/day; usual total insulin requirement 0.5-1 units/kg/day; adolescents may require higher doses; give 30min before meals or per sliding scale; onset 0.5-1h, peak 2-4h, duration up to 24h (short to intermediate-acting insulin) Dose: 0.1 units/kg/h IV; Start: 1-2h after initial fluid tx; Info: give w/ IV potassium; for pts w/ marked insulin sensitivity, may decr. dose to <0.05 units/kg/h IV; add dextrose 5% when blood glucos Continue reading >>

Humulin R

Humulin R

Humulin R (insulin (human recombinant)) is a hormone that is produced in the body used to treat diabetes. Common side effects of Humulin R include: injection site reactions (e.g., pain, redness, irritation). Low blood sugar (hypoglycemia) is the most common side effect of Humulin R. Symptoms of low blood sugar include headache, hunger, weakness, sweating, tremors, irritability, trouble concentrating, rapid breathing, fast heartbeat, fainting, or seizure (severe hypoglycemia can be fatal). Tell your doctor if you have serious side effects of Humulin R including: signs of low potassium level in the blood (such as muscle cramps, weakness, irregular heartbeat). Each patient's diabetes is different, and the injection schedule and use of Humulin R is individualized. A doctor determines which insulin to use, how much, and when and how often to inject it. Humulin R may interact with albuterol, clonidine, reserpine, guanethidine, or beta-blockers. Tell your doctor all medications you are taking. Tell your doctor if you are pregnant before using Humulin R. If you are planning pregnancy, discuss a plan for managing your blood sugars with your doctor before you become pregnant. Your doctor may switch the type of insulin you use during pregnancy. This medication does not pass into breast milk. Consult your doctor before breastfeeding. Insulin needs may change while breastfeeding. Our Humulin R (insulin (human recombinant)) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Continue reading >>

Indication For Humulin R U-500

Indication For Humulin R U-500

If your A1C is uncontrolled on high doses of standard insulin—more than 200 units a day—you may have another diabetes treatment option. Humulin® R U-500 is 5x concentrated insulin* available in a U-500 KwikPen® or syringe and vial. U-500 lowered high blood sugar in a clinical study. † If your doctor has prescribed U-500 for you or a loved one, learn more here. † 24 week, open-label, randomized trial to compare the efficacy and safety of 2 dosing regiments (TID, n=162 vs BID, n=163) for U-500 insulin replacing high dose U-100 insulin (>200 units per day) with or without oral antihyperglycemic drugs in adult patients with uncontrolled type 2 diabetes. These regimens were found to be equivalent for A1C reduction over 24 weeks, and both were efficacious. Study conducted with U-100 insulin syringes and Humulin R U-500 vials. Continue reading >>

Insulin Human Monograph For Professionals

Insulin Human Monograph For Professionals

Insulin Human Monograph for Professionals Insulin Human Monograph for Professionals Submitted by Guest (not verified) on Thu, 11/21/2013 - 04:09 Brands: Humulin, Humulin 70/30, Humulin 70/30 Pen, Humulin 50/50, Humulin L, Humulin N, Humulin R, Humulin U Ultralente, Novolin, Novolin 70/30, Novolin 70/30 Innolet, Novolin 70/30 PenFill, Novolin N, Novolin R Antidiabetic agent; a biosynthetic protein that is structurally identical to endogenous insulin secreted by the beta cells of the human pancreas.12356385365717576Available as short-acting, rapid-acting, intermediate-acting, or long-acting insulins.123563853657175[sup]76 Replacement therapy for the management of diabetes mellitus.567812113Human insulin manufactured using recombinant DNA technology is replacing pork insulin; future availability of animal insulins is uncertain.[sup]103 Insulin is required in all patients with type 1 diabetes mellitus, and mandatory in the treatment of diabetic ketoacidosis and hyperosmolar hyperglycemic states. Also used in patients with type 2 diabetes mellitus when weight reduction, proper dietary regulation, and/or oral antidiabetic agents have failed to maintain satisfactory glycemic control in both the fasting and postprandial state. Diet should be emphasized as the primary form of treatment when initiating therapy for patients with type 2 diabetes mellitus who do not have severe symptoms; caloric restriction and weight reduction are essential in obese patients. The American Diabetes Association (ADA) and many clinicians recommend the use of physiologically based, intensive insulin regimens (i.e., 3 or more insulin injections daily with dosage adjusted according to the results of multiple daily blood glucose determinations [e.g., at least 4 times daily], dietary intake, and anticipat Continue reading >>

Drug Formula Information - Blue Shield Of California

Drug Formula Information - Blue Shield Of California

USES: Concentrated insulin regular is used with a proper diet and exercise program to control high blood sugar in people with diabetes who require large doses of insulin (more than 200 units per day). Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. This man-made insulin product is the same as human insulin. It replaces the insulin that your body would normally make. It works right away like regular insulin but its effects last longer. It works by helping blood sugar (glucose) get into cells so your body can use it for energy. This medication may be used alone or with other oral diabetes drugs (such as metformin). HOW TO USE: Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor, diabetes educator, or pharmacist. This insulin product is a high-strength concentrated liquid. Learn all preparation and usage instructions, including how to measure the correct dose using the proper syringe, from your health care professional and the product package. Before using, check this product visually for particles or discoloration. If either is present, do not use the insulin. This insulin product should be clear and colorless. Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin and to avoid developing problems under the skin (lipodystrophy). This insulin product may be injected in the stomach area, the thigh, the buttocks, or the back of the upper arm. Do not inject into a vein or muscle because very low blood s Continue reading >>

Insulin Human

Insulin Human

Class: Insulins ATC Class: A10AB01 VA Class: HS501 Molecular Formula: C257H383N65O77S 6 CAS Number: 11061-68-0 Brands: HumuLIN, HumuLIN 70/30, HumuLIN 70/30 Pen, HumuLIN 50/50, HumuLIN L, HumuLIN N, HumuLIN R, HumuLIN U Ultralente, NovoLIN, NovoLIN 70/30, NovoLIN 70/30 Innolet, NovoLIN 70/30 PenFill, NovoLIN N, NovoLIN R Introduction Antidiabetic agent; a biosynthetic protein that is structurally identical to endogenous insulin secreted by the beta cells of the human pancreas.1 2 3 5 6 38 53 65 71 75 76 Available as short-acting, rapid-acting, intermediate-acting, or long-acting insulins.1 2 3 5 6 38 53 65 71 75 76 Uses for Insulin Human Diabetes Mellitus Replacement therapy for the management of diabetes mellitus.5 6 7 8 12 113 Human insulin manufactured using recombinant DNA technology is replacing pork insulin; future availability of animal insulins is uncertain.103 Insulin is required in all patients with type 1 diabetes mellitus, and mandatory in the treatment of diabetic ketoacidosis and hyperosmolar hyperglycemic states. Also used in patients with type 2 diabetes mellitus when weight reduction, proper dietary regulation, and/or oral antidiabetic agents have failed to maintain satisfactory glycemic control in both the fasting and postprandial state. Diet should be emphasized as the primary form of treatment when initiating therapy for patients with type 2 diabetes mellitus who do not have severe symptoms; caloric restriction and weight reduction are essential in obese patients. The American Diabetes Association (ADA) and many clinicians recommend the use of physiologically based, intensive insulin regimens (i.e., 3 or more insulin injections daily with dosage adjusted according to the results of multiple daily blood glucose determinations [e.g., at least 4 times d Continue reading >>

Ndc 0002-8501 Humulin R U-500

Ndc 0002-8501 Humulin R U-500

Package Carton Humulin R U-500 Kwikpen 3 Ml (500 Units Per Ml) HUMULINR U-500 is a concentrated human insulin indicated to improve glycemic control in adult and pediatric patients with diabetes mellitus requiring more than 200units of insulin per day. The safety and efficacy of HUMULIN R U-500 used in combination with other insulins has not been determined. The safety and efficacy of HUMULIN R U-500 delivered by continuous subcutaneous infusion has not been determined. 2.1 Important Administration Instructions Prescribe HUMULINR U-500 ONLY to patients who require more than 200units of insulin per day. Train patients on proper use and injection technique before initiating HUMULINR U-500. Training reduces the risk of administration errors such as needle sticks and dosing errors. To avoid serious dosing errors for patients using the vial presentation, determine the type of syringe that the patient will use to deliver the prescribed dose of HUMULIN R U-500, instruct the patient on how to correctly draw the prescribed dose of HUMULINR U-500 into the particular syringe, and confirm that the patient has understood these instructions and can correctly draw the prescribed dose of HUMULIN R U-500 with their syringe [see Dosage and Administration (2.4) and Warnings and Precautions (5.1)]. Instruct patients to always check the insulin label before administration to confirm the correct insulin product is being used [see Warnings and Precautions (5.1)]. Inspect HUMULINR U-500 visually for particulate matter and discoloration. Only use HUMULINR U-500 if the solution appears clear and colorless. Instruct patients to inject HUMULINR U-500 subcutaneously into the thigh, upper arm, abdomen, or buttocks. Rotate injection sites within the same region from one injection to the next to reduc Continue reading >>

Dailymed - Humulin R - Insulin Human Injection, Solution

Dailymed - Humulin R - Insulin Human Injection, Solution

THIS LILLY HUMAN INSULIN PRODUCT DIFFERS FROM ANIMAL-SOURCE INSULINS BECAUSE IT IS STRUCTURALLY IDENTICAL TO THE INSULIN PRODUCED BY YOUR BODY'S PANCREAS AND BECAUSE OF ITS UNIQUE MANUFACTURING PROCESS. ANY CHANGE OF INSULIN SHOULD BE MADE CAUTIOUSLY AND ONLY UNDER MEDICAL SUPERVISION. CHANGES IN STRENGTH, MANUFACTURER, TYPE (E.G., REGULAR, NPH, ANALOG), SPECIES, OR METHOD OF MANUFACTURE MAY RESULT IN THE NEED FOR A CHANGE IN DOSAGE. SOME PATIENTS TAKING HUMULIN (HUMAN INSULIN, rDNA ORIGIN) MAY REQUIRE A CHANGE IN DOSAGE FROM THAT USED WITH OTHER INSULINS. IF AN ADJUSTMENT IS NEEDED, IT MAY OCCUR WITH THE FIRST DOSE OR DURING THE FIRST SEVERAL WEEKS OR MONTHS. Insulin is a hormone produced by the pancreas, a large gland that lies near the stomach. This hormone is necessary for the body's correct use of food, especially sugar. Diabetes occurs when the pancreas does not make enough insulin to meet your body's needs. To control your diabetes, your doctor has prescribed injections of insulin products to keep your blood glucose at a near-normal level. You have been instructed to test your blood regularly for glucose. Studies have shown that some chronic complications of diabetes such as eye disease, kidney disease, and nerve disease can be significantly reduced if the blood sugar is maintained as close to normal as possible. Proper control of your diabetes requires close and constant cooperation with your doctor. Despite diabetes, you can lead an active and healthy life if you eat a balanced diet, exercise regularly, and take your insulin injections as prescribed by your doctor. Always keep an extra supply of insulin as well as a spare syringe and needle on hand. Always wear diabetic identification so that appropriate treatment can be given if complications occur away from Continue reading >>

Humulin R Pdr+ Consumer Monograph | Pdr.net

Humulin R Pdr+ Consumer Monograph | Pdr.net

What is this medication and its most common uses? Humulin R is used to control high blood sugar in people with diabetes. What should I know when beginning and continuing on this medication? Your body needs insulin to turn sugar into energy. Diabetes develops when your body does not make enough insulin or does not properly use the insulin it makes. Humulin R U-100 may help control your blood sugar levels by allowing blood sugar to move from your bloodstream into your cells for energy. What are the beneficial effects of this medication and when should I begin to have results? What: Lowering your blood sugar to a normal level may prevent or delay potential complications associated with diabetes, such as blindness, kidney failure, or heart problems. Humulin R U-100 works by controlling the rise in blood sugar when you eat. When: Humulin R U-100 starts working 30 minutes after injection and the effects may last up to 8 hours. Check your blood sugar regularly and as your healthcare provider tells you to. Your healthcare provider will also order blood tests to measure your blood sugar levels and your hemoglobin A1C (measures your average blood sugar levels over a 2- to 3-month period). It is important to stay on your prescribed diet and exercise program, as this will also affect the results of your blood tests. What are the possible side effects of this medication? The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication. More common side effects may include: low blood sugar or injection-site reactions. Symptoms of low blood sugar include: anxiety, restlessnes Continue reading >>

Humulin R, Novolin R (insulin Regular Human) Dosing, Indications, Interactions, Adverse Effects, And More

Humulin R, Novolin R (insulin Regular Human) Dosing, Indications, Interactions, Adverse Effects, And More

Never share pen between patients even if needle is changed Use with caution in patients with decreased insulin requirements: Diarrhea, nausea/vomiting, malabsorption, hypothyroidism, renal impairment, and hepatic impairment Use with caution in patients with increased insulin requirements: Fever, hyperthyroidism, trauma, infection, and surgery Rapid changes in serum glucose may induce symptoms of hypoglycemia; increase monitoring with changes to insulin dosage, co-administered glucose lowering medications, meal pattern, physical activity; and in patients with renal impairment or hepatic impairment or hypoglycemia unawareness Hypoglycemia is the most common cause of adverse reactions (headache, tachycardia, etc) May cause a shift in potassium from extracellular to intracellular space, possibly leading to hypokalemia; caution when coadministered with potassium-lowering drugs or when administered to patients with a condition that may decrease potassium Thiazolidinediones are peroxisome proliferator-activated receptor (PPAR)-gamma agonists and can cause dose-related fluid retention, particularly when used in combination with insulin; fluid retention may lead to or exacerbate heart failure; monitor for signs and symptoms of heart failure, treat the patient accordingly, and consider discontinuing thiazolidinediones Change in insulin regimen should be carried out under close medical supervision and frequency of blood glucose monitoring should be increased Severe, life-threatening, generalized allergy, including anaphylaxis, can occur; discontinue therapy if indicated Not for mixing with any insulin for intravenous use or with insulins other than NPH insulin for subcutaneous use Continue reading >>

Medi-mouse Drug Search Results

Medi-mouse Drug Search Results

BC Pharmacare: LCA PARTIAL benefit for Groups I2 Unit Price: 4.93 Packaging: 3 ML Monograph: CMA-Lexicomp or Epocrates insulin biosynthetic human br 100unit ml HUMULIN R (KWIKPEN) Unit Price: n/a Packaging: 5X3ML Monograph: CMA-Lexicomp or Epocrates Unit Price: n/a Packaging: 3ML / 5X3ML Monograph: CMA-Lexicomp or Epocrates Unit Price: n/a Packaging: 3ML/ 3X3ML Monograph: CMA-Lexicomp or Epocrates insulin detemir 100unit ml LEVEMIR PENFILL BC Pharmacare: LCA PARTIAL benefit for Groups I2,PC Unit Price: 3.99 Packaging: 3ML Monograph: CMA-Lexicomp or Epocrates insulin isophane human biosynthetic 70unit ml, insulin injection human biosynthetic 30unit ml BC Pharmacare: FULL benefit for Groups I2,PC Unit Price: n/a Packaging: 3ML Monograph: CMA-Lexicomp or Epocrates insulin isophane human biosynthetic 60unit ml, insulin injection human biosynthetic 40unit ml BC Pharmacare: FULL benefit for Groups I2,PC Unit Price: n/a Packaging: 3ML Monograph: CMA-Lexicomp or Epocrates insulin isophane human biosynthetic 50unit ml, insulin injection human biosynthetic 50unit ml BC Pharmacare: FULL benefit for Groups I2,PC Unit Price: n/a Packaging: 3ML Monograph: CMA-Lexicomp or Epocrates insulin lispro 25unit ml, insulin lispro protamine suspension 75unit ml Continue reading >>

Humulin (insulin)

Humulin (insulin)

HUMULIN® Lilly Insulin, Human Biosynthetic Antidiabetic Agent Action And Clinical Pharmacology: Humulin is a polypeptide hormone consisting of a 21 amino acid A-chain and a 30 amino acid B-chain linked by two disulfide bonds. Humulin is found to be chemically, physically, biologically and immunologically equivalent to pancreatic human insulin which differs slightly from porcine or bovine insulin in amino acid composition. Studies indicate immunogenicity problems with biosynthetic human insulin (BHI) produced by recombinant DNA technology are less likely than with insulin derived from animal origin. Biosynthetic human insulin is devoid of all protein contaminants of pancreatic origin normally present in trace amounts in all insulins of pancreatic origin. The purification procedures used in the manufacture of biosynthetic human insulin result in a product which contains an insufficient quantity of E. coli polypeptides to be antigenic in deliberately sensitized animals. No antibodies to E. coli polypeptides have been detected in specifically designed radioimmunoassay methods examining patient serum samples. The administration of suitable doses of insulin to patients with diabetes mellitus, along with controlled diet and exercise, temporarily restores their ability to metabolize carbohydrates, fats and proteins; to store glycogen in the liver; and to convert glucose to fat. When given in suitable doses at regular intervals to a patient with diabetes mellitus, the blood sugar is maintained within a reasonable range, the urine remains relatively free of sugar and ketone bodies, and diabetic acidosis and coma are prevented. Insulin preparations differ in onset, peak and duration of action. The addition of protamine to insulin, in the presence of zinc, produces a stable comple Continue reading >>

Insulin Regular | Drug Monograph | Pediatric Care Online | Aap Point-of-care-solutions

Insulin Regular | Drug Monograph | Pediatric Care Online | Aap Point-of-care-solutions

This is the touchback warning message modal. The following terms and conditions are an agreement (the Agreement) governing your access and use of the [Pediatric Care Online (PCO)] website(the Website) and its content (collectively, the Materials). Please read these terms carefully. If you agree to all of the terms ofthis Agreement please click the I Agree button below to indicate your acceptance and you will automatically be taken to the Website. If you do notwish to be bound by these terms, you may not access or use the Materials - in such event you should click the I Do Not Agree button below and followthe instructions to obtain a refund of any subscription fees paid by you. 1. Materials. The American Academy of Pediatrics (AAP) hosts the Website and related Materials on its servers and makesthem available via the Internet to subscribers for non-commercial research and education purposes and for use in providing healthcare services. Inconsideration of payment of the applicable subscription fee, the AAP is willing to provide access to the Materials to you and, if applicable, your Users(as defined below), subject to all of the following terms. You acknowledge that certain portions or content of the Website or Materials may containinformation, materials or content provided by a third party provider or licensor (a Provider) and that the liability and obligations of suchProviders is limited as provided herein. (a) Subject to the terms of this Agreement, the AAP grants to you a non-exclusive, non-assignable and non-transferable right to access and use theMaterials for the purpose of providing healthcare services to your patients (the License). (b) User means you and your authorized users for whom a subscription has been activated. For individual enrollment use of the Mater Continue reading >>

Insulin (regular)

Insulin (regular)

(in'su-lin) Humulin R, Novolin R, Regular Insulin, Velosulin, Velosulin BR, Velosulin Human Classifications: hormone and synthetic substitute; antidiabetic agent; insulin Pregnancy Category: B 100 units/mL Short-acting, clear, colorless solution of exogenous unmodified insulin extracted from beta cells in pork pancreas or synthesized by recombinant DNA technology (human). Enhances transmembrane passage of glucose across cell membranes of most body cells and by unknown mechanism may itself enter the cell to activate selected intermediary metabolic processes. Promotes conversion of glucose to glycogen. It lowers blood glucose levels by increasing peripheral glucose uptake, especially by skeletal muscle and fat tissue, and by inhibiting the liver from changing glycogen to glucose. Emergency treatment of diabetic ketoacidosis or coma, to initiate therapy in patient with insulin-dependent diabetes mellitus, and in combination with intermediate-acting or long-acting insulin to provide better control of blood glucose concentrations in the diabetic patient. Used IV to stimulate growth hormone secretion (glucose counter regulatory hormone) to evaluate pituitary growth hormone reserve in patient with known or suspected growth hormone deficiency. Other uses include promotion of intracellular shift of potassium in treatment of hyperkalemia (IV) and induction of hypoglycemic shock as therapy in psychiatry. Hypersensitivity to insulin animal protein. Pregnancy (category B), lactation, renal impairment, hepatic impairment, and older adults. Safety and efficacy in children <2 y are not established. Diabetes Mellitus Adult: SC 5–10 U 15–30 min a.c. and h.s. (dose adjustments based on blood glucose determinations) Child: SC 2–4 U 15–30 min a.c. and h.s. (dose adjustments based on Continue reading >>

Human Regular Insulin

Human Regular Insulin

18 Hormones and other endocrine drugs and contraceptives Human Regular Insulin's dosage details are as follows: No data regarding the neonatal dosage details of Human Regular Insulin is available. Site designed by Pharma Professional Services and developed by Hasan Computing Systems Information provided on this Web site is neither intended nor implied to be a substitute for professional medical advice. You should not use this information on this web site or the information on links from this site to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. Pharma Professional Services advises you to always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition. You should check with your physician/health care provider before using any of the means or methods presented on this site. If you undertake any treatment methods displayed on this site without such supervision, you are solely and entirely responsible for it's outcome. Pharma Professional Services nor anyone connected with this site cannot be held responsible for your actions nor any conditions resulting thereof. Continue reading >>

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