Humulin R Dosage

Insulet To Develop New Version Of The Omnipod Insulin Pump For Use With Humulin R U-500 Concentrated Insulin For People With Type 2 Diabetes

Insulet to Develop New Version of the OmniPod Insulin Pump for Use With Humulin R U-500 Concentrated Insulin for People With Type 2 Diabetes Insulet to Develop New Version of the OmniPod Insulin Pump for Use With Humulin R U-500 Concentrated Insulin for People With Type 2 Diabetes 30.3 KB Insulet to Develop New Version of the OmniPod Insulin Pump for Use With Humulin R U-500 Concentrated Insulin for People With Type 2 Diabetes (NASDAQ: PODD), the leader in tubeless insulin pump technology with its OmniPod Insulin Management System, today announced it has entered into an agreement with Eli Lilly and Company in which will develop a new version of the OmniPod insulin pump specifically designed to deliver Humulin R U-500 insulin, (regular U-500 [Concentrated] insulin human injection, USP [rDNA origin]), a concentrated form of insulin used by people with highly insulin resistant type 2 diabetes. is partnering with Eli Lilly and Company on the clinical development program to evaluate the safety and efficacy of the combined delivery system. As the incidence of severe insulin resistance continues to rise, more and more people with type 2 diabetes are requiring significantly higher doses of insulin in order to control their blood glucose. This new version of the OmniPod System would be the first insulin pump designed with specific feature modifications to deliver Humulin R U-500 insulin. Given the rapid increases in rates of obesity and corresponding increases in daily insulin requirements, the new delivery system, if approved, would represents a significant and growing opportunity for people with highly insulin resistant type 2 diabetes to potentially better manage their disease with such a product. "We are pleased to develop the first insulin pump specifically for Humulin R U Continue reading >>

Humulin R Dosage

Humulin R U-100, when used subcutaneously, is usually given three or more times daily before meals. The dosage and timing of Humulin R U-100 should be individualized and determined, based on the physician's advice, in accordance with the needs of the patient. Humulin R U-100 may also be used in combination with oral antihyperglycemic agents or longer-acting insulin products to suit the needs of the individual patients with diabetes. The injection of Humulin R U-100 should be followed by a meal within approximately 30 minutes of administration. The average range of total daily insulin requirement for maintenance therapy in insulin-treated patients without severe insulin resistance lies between 0.5 and 1 unit/kg/day. However, in pre-pubertal children it usually varies from 0.7 to 1 unit/kg/day, but can be much lower during the period of partial remission. In situations of insulin resistance, e.g. during puberty or due to obesity, the daily insulin requirement may be substantially higher. Initial dosages for patients with diabetes are often lower, e.g., 0.2 to 0.4 units/kg/day. Humulin R U-100 may be administered by subcutaneous injection in the abdominal wall, the thigh, the gluteal region or in the upper arm. Subcutaneous injection into the abdominal wall ensures a faster absorption than from other injection sites. Injection into a lifted skin fold minimizes the risk of intramuscular injection. Injection sites should be rotated within the same region. As with all insulin, the duration of action will vary according to the dose, injection site, blood flow, temperature, and level of physical activity. Intravenous administration of Humulin R U-100 is possible under medical supervision with close monitoring of blood glucose and potassium levels to avoid hypoglycemia and hypok Continue reading >>

Insulin Regular Human (rx, Otc)

Dosage Forms & Strengths injectable solution Type 1 Diabetes Mellitus Initial: 0.2-0.4 units/kg/day SC divided q8hr or more frequently Maintenance: 0.5-1 unit/kg/day SC divided q8hr or more frequently; in insulin-resistant patients (eg, due to obesity), substantially higher daily insulin may be required Approximately 50-75% of the total daily insulin requirements are given as intermediate- or long-acting insulin administered in 1-2 injections; rapid- or short-acting insulin should be used before or at mealtimes to satisfy the remainder balance of the total daily insulin requirements Premixed combinations are available that deliver rapid- or short-acting components at the same time as the intermediate- or long-acting component Type 2 Diabetes Mellitus Type 2 diabetes inadequately controlled by diet, exercise, or oral medication: Suggested beginning dose of 10 units/day SC (or 0.1-0.2 unit/kg/day) in evening or divided q12hr Severe Hyperglycemia (Diabetic Ketoacidosis) 0.1 unit/kg/hr IV continuous infusion; if serum glucose does not fall by 50 mg/dL in the first hour, check hydration status; if possible, double the insulin hourly until glucose levels fall at the rate of 50-75 mg/dL/hr; decrease infusion to 0.05-0.1 unit/kg/hour when blood sugar reaches 250 mg/dL Dosing Considerations Dosage of human insulin, which is always expressed in USP units, must be based on the results of blood and urine glucose tests and must be carefully individualized to optimal effect Dose adjustments should be based on regular blood glucose testing Adjust to achieve appropriate glucose control Look for consistent pattern in blood sugars for >3 days Same time each day: Compare blood glucose levels with previous levels found at that time of day For each time of day: Calculate blood glucose range Continue reading >>

Regular-insulin, Injectable Solution

Insulin regular (human) injectable solution is available as brand-name drugs. It’s not available in a generic form. Brand names: HumuLIN R, NovoLIN R. Insulin regular (human) comes in three forms: injectable solution, powder for inhalation, and an intravenous injection. Insulin regular (human) injectable solution is used along with a healthy diet and exercise to control high blood sugar caused by type 1 or type 2 diabetes. Low blood sugar warning: Insulin regular (human) can cause low blood sugar (hypoglycemia). If you have a low blood sugar reaction, you’ll need to treat it right away. Symptoms can include: hunger dizziness shakiness lightheadedness sweating irritability headache fast heart rate confusion Thiazolidinedione warning: Taking certain diabetes pills called thiazolidinediones (TZDs) with insulin regular (human) may cause heart failure in some people. This can happen even if you’ve never had heart failure or heart problems before. If you already have heart failure, it may get worse. Your healthcare provider should monitor you closely while you’re taking TZDs with insulin regular (human). Tell your doctor right away if you have new or worse symptoms of heart failure, including: shortness of breath swelling of your ankles or feet sudden weight gain Infection warning: Do not share insulin vials, syringes or prefilled pens with other people. Sharing or reusing needles or syringes with another person puts you and others at risk for various infections. Insulin regular (human) is available as an over-the-counter (OTC) and prescription drug. It comes as a solution that you inject subcutaneously (under your skin). Your healthcare provider will show you how to give yourself the injection. You can also follow this guide for self-injection. Insulin regular (human Continue reading >>

Humulin R Price Comparison: Uses, Dosage, Form & Side Effects

It is very important to know about what medicine is given by the doctor, for what condition, and when it needs to be taken in what dose. This information given by the doctor is called Prescription. The patients should be familiar with the medicine prescription, and the details about the medicine before purchasing it and using it. Some medications need not be prescribed by healthcare practitioners and can be purchased and used without prescription by the patients; these are called over-the-counter medications. Read the drug prescription information of Humulin R before taking it. Humulin is synthesized in a special non-disease-producing laboratory strain of Escherichia coli bacteria that has been genetically altered by the addition of the gene for human insulin production. HumulinR(U-500) consists of zinc-insulin crystals dissolved in a clear fluid. HumulinR(U-500) is a sterile solution and is for subcutaneous injection. It should not be used intravenously or intramuscularly. The concentration of HumulinR(U-500) is 500units/mL.Each milliliter contains 500units of biosynthetic human insulin, 16mg glycerin, 2.5mgMetacresol as a preservative, and zinc-oxide calculated to supplement endogenous zinc to obtain a total zinc content of 0.017mg/100units. Sodium hydroxide and/or hydrochloric acid may be added during manufacture to adjust the pH. Humulin R (insulin human SUBCUTANEOUS) is indicated for the following: HumulinR(U-500) is especially useful for the treatment of diabetic patients with marked insulin resistance (daily requirements more than 200units), since a large dose may be administered subcutaneously in a reasonable volume. Humulin R is a form of insulin usually used to treat diabetes. Some of the most prescribed drugs in this class include: Lantus; Humalog; Novolog; Continue reading >>

[full Text] Update On Insulin Treatment For Dogs And Cats: Insulin Dosing Pens And | Vmrr

Editor who approved publication: Professor Takashi Agui Ann Thompson,1 Patty Lathan,2 Linda Fleeman3 1School of Veterinary Science, The University of Queensland, Gatton, QLD, Australia; 2College of Veterinary Medicine Mississippi State University, Starkville, MS, USA; 3Animal Diabetes Australia, Melbourne, VIC, Australia Abstract: Insulin therapy is still the primary therapy for all diabetic dogs and cats. Several insulin options are available for each species, including veterinary registered products and human insulin preparations. The insulin chosen depends on the individual patient's requirements. Intermediate-acting insulin is usually the first choice for dogs, and longer-acting insulin is the first choice for cats. Once the insulin type is chosen, the best method of insulin administration should be considered. Traditionally, insulin vials and syringes have been used, but insulin pen devices have recently entered the veterinary market. Pens have different handling requirements when compared with standard insulin vials including: storage out of the refrigerator for some insulin preparations once pen cartridges are in use; priming of the pen to ensure a full dose of insulin is administered; and holding the pen device in place for several seconds during the injection. Many different types of pen devices are available, with features such as half-unit dosing, large dials for visually impaired people, and memory that can display the last time and dose of insulin administered. Insulin pens come in both reusable and disposable options. Pens have several benefits over syringes, including improved dose accuracy, especially for low insulin doses. Keywords: diabetes, mellitus, canine, feline, NPH, glargine, porcine lente Insulin therapy is the cornerstone of management for dia Continue reading >>

Insulin Regular, Concentrated (u-500) (cont.)

A A A What happens if I miss a dose (Humulin R (Concentrated))? Follow your doctor's directions if you miss a dose of insulin. To prevent missed doses, be sure to keep insulin on hand at all times, especially when you are traveling away from home. What happens if I overdose (Humulin R (Concentrated))? Seek emergency medical attention if you think you have used too much of this medicine. An insulin overdose can cause life-threatening hypoglycemia. Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, seizure (convulsions), or coma. What should I avoid while using concentrated insulin (Humulin R (Concentrated))? Avoid drinking alcohol while using concentrated insulin. Alcohol can lower your blood sugar. What other drugs will affect concentrated insulin (Humulin R (Concentrated))? Do not use any other insulins or diabetes medications you take by mouth, unless your doctor tells you to. Hyperglycemia (high blood sugar) may be more likely to occur if you also use certain other medications such as: diuretics (water pills); steroids (prednisone and others); phenothiazines (Compazine and others); thyroid medicine (Synthroid and others); birth control pills and other hormones; seizure medicines (Dilantin and others); diet pills, or medicines to treat asthma, colds or allergies. Hypoglycemia (low blood sugar) may be more likely to occur if you also use certain other medications such as: some nonsteroidal anti-inflammatory drugs (NSAIDs); aspirin or other salicylates (including Pepto-Bismol); sulfa drugs (Bactrim and others); a monoamine oxidase inhibitor (MAOI); or beta-blockers (Tenormin and others). This list is not complete and there may be other drugs that can interact with concentrated insulin. Continue reading >>

Humulin R: Solution For Injection (100u)

Brand 100% *Brand contains same active ingredient but may not represent FDA-approved generic equivalent 100U Ingredients Close All Sections Reported Side Effects for Humulin R 100units/ml Solution for Injection Close *This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different. Close Class B - Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women. OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester. Class B - Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women. OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester. Class B - Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women. OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester. Continue reading >>

Humulin R Dosage

There is no set Humulin R dosage that works for all people or for the same person in all situations. Carbohydrate counting and measuring your blood sugar levels before and after meals may help you determine an accurate dosage. Generally, smaller doses of Humulin R are necessary after meals with a low carbohydrate content, while larger doses are necessary after meals with a high carbohydrate content. The dose of Humulin R ( regular insulin ) that your healthcare provider recommends will vary, depending on a number of factors, including: How you respond to Humulin R (especially as measured by your blood sugar levels) Other medications you are taking, including other diabetes medications As is the case with any medicine, do not adjust your dosage unless your healthcare provider specifically instructs you to do so. There is no "standard" Humulin R dose that will work for all people or even for the same person in all situations. Humulin R is used to control the rise in blood sugar due to meals. It begins working within 30 to 60 minutes, peaks between 50 and 120 minutes, and lasts for 5 to 8 hours (although there may be considerable variation depending on the particular individual). You may be asked to measure your blood sugar before and after meals, and your healthcare provider may recommend carbohydrate counting. Both of these things can help you and your healthcare provider know how to dose your Humulin R. In general, smaller doses of Humulin R are necessary for meals with a low carbohydrate content, while larger doses are necessary for meals with a high carbohydrate content. Continue reading >>

Humulin R (u-500) (lilly), Drug Reference Encyclopedia

THIS Lilly HUMAN INSULIN PRODUCT DIFFERS FROM ANIMAL-SOURCE INSULINS BECAUSE IT IS STRUCTURALLY IDENTICAL TO THE INSULIN PRODUCED BY YOUR BODY'S PANCREAS AND BECAUSE OF ITS UNIQUE MANUFACTURING PROCESS. ANY CHANGE OF INSULIN SHOULD BE MADE CAUTIOUSLY AND ONLY UNDER MEDICAL SUPERVISION. CHANGES IN PURITY, STRENGTH, BRAND (MANUFACTURER), TYPE (REGULAR, NPH, LENTE, ETC), SPECIES (BEEF, PORK, BEEF-PORK, HUMAN), AND/OR METHOD OF MANUFACTURE (rDNA VERSUS ANIMAL-SOURCE INSULIN) MAY RESULT IN THE NEED FOR A CHANGE IN DOSAGE. SOME PATIENTS TAKING HUMULIN (HUMAN INSULIN, rDNA ORIGIN, Lilly ) MAY REQUIRE A CHANGE IN DOSAGE FROM THAT USED WITH ANIMAL-SOURCE INSULINS. IF AN ADJUSTMENT IS NEEDED, IT MAY OCCUR WITH THE FIRST DOSE OR DURING THE FIRST SEVERAL WEEKS OR MONTHS. This insulin preparation contains 500 units of insulin in each milliliter. Extreme caution must be observed in the measurement of dosage because inadvertent overdose may result in irreversible insulin shock. Serious consequences may result if it is used other than under constant medical supervision. Humulin is synthesized in a special non-disease-producing laboratory strain ofEscherichia colibacteria that has been genetically altered by the addition of the gene for human insulin production. Humulin R (U-500) consists of zinc-insulin crystals dissolved in a clear fluid. Humulin R (U-500) is a sterile solution and is for subcutaneous injection. It should not be used intravenously or intramuscularly. The concentration of Humulin R (U-500) is 500 units/mL. Each milliliter contains 500 units of biosynthetic human insulin, 16 mg glycerin, 2.5 mgm-cresol as a preservative, and zinc-oxide calculated to supplement endogenous zinc to obtain a total zinc content of 0.017 mg/100 units. Sodium hydroxide and/or hydrochloric aci Continue reading >>

U-500 Insulin: Not For Ordinary Use

US Pharm. 2010;35(5)(Diabetes suppl):14-17. If not already seeing them, pharmacists should anticipate encountering prescriptions for U-500 regular insulin. U-500 insulin is five times more potent than standard U-100 and is utilized in patients requiring high doses of insulin. Prescribing of U-500 is on the rise due to the obesity epidemic, adoption of tighter glucose control protocols, increased insulin resistance, and utilization of insulin pumps.1 Potential for adverse drug events exists due to unfamiliarity with U-500 and its higher potency. This review is intended to enable safe provision of U-500 insulin by increasing awareness of the drug and its correct administration. As insulin resistance worsens, greater doses of insulin are required to meet glycemic goals. This is especially true for persons with insulin resistance (IR) syndromes. These are patients with an insulin requirement of 200 U/day and greater. FIGURE 1 illustrates the body’s response to insulin as the dose increases. Note that for patients with IR syndromes, the dose response to insulin is significantly diminished. This is especially true when insulin doses exceed 100 U. However, this phenomenon does not mean greater doses are without effect.2 In fact, higher doses of insulin eventually achieve therapeutic targets. For this reason, use of high-dose insulin should not be avoided in insulin-resistant patients. Otherwise, these patients will fail to achieve glycemic goals by underdosing insulin. Use of standard insulin becomes problematic when patients require over 200 U/day or greater than 100 U per injection. At these doses, the volume of U-100 insulin is physically too large for single subcutaneous administration, and multiple injections are required to deliver a single dose. With more injections, Continue reading >>

Humulin R (insulin Human Subcutaneous) - Indications And Dosage

Humulin R (Insulin Human Subcutaneous) - Indications and Dosage HumulinR(U500) is especially useful for the treatment of diabetic patients with marked insulin resistance (daily requirements more than 200units), since a large dose may be administered subcutaneously in a reasonable volume. HumulinR(U500) should only be administered subcutaneously. It is inadvisable to inject HumulinR(U500) intravenously because of possible inadvertent overdosage. It is recommended that an insulin syringe or tuberculintype syringe be used for the measurement of dosage. Variations in dosage are frequently possible in the insulinresistant patient, since the individual is unresponsive to the pharmacologic effect of the insulin. Nevertheless, accuracy of measurement is to be encouraged because of the potential danger of the preparation. Insulin should be kept in a cold place, preferably in a refrigerator, but must not be frozen. Do not inject insulin that is not waterclear. Discoloration, turbidity, or unusual viscosity indicates deterioration or contamination. Use of a package of insulin should not be started after the expiration date stamped on it. Continue reading >>

U.s. Food And Drug Administration Approves Humulin® R U-500 Kwikpen®

INDIANAPOLIS, Jan. 21, 2016 /PRNewswire/ -- The U.S. Food and Drug Administration (FDA) has approved Eli Lilly and Company's (NYSE: LLY) Humulin® R U-500 KwikPen®(insulin human injection) 500 units/mL, a pre-filled device containing Humulin R U-500, a highly concentrated formulation of insulin. Humulin R U-500 is the only FDA-approved insulin that is five-times more concentrated than standard U-100 insulin. This insulin is used to treat high blood sugar in people with type 1 and type 2 diabetes who need more than 200 units of insulin per day. The safety and efficacy of Humulin R U-500 used in combination with other insulins or delivered by an insulin infusion pump has not been determined. "People with diabetes and severe insulin resistance who have become poorly responsive to the effects of insulin may require much higher insulin doses – more than 200 units per day – to help keep their blood sugar levels on target," said Jeffrey A. Jackson, MD, FACE, CDE, Medical Fellow, US Medical Affairs, Lilly Diabetes. "For these patients, the U-500 KwikPen is now available as a convenient alternate option to deliver a large dose of insulin in a reasonable volume. It was specifically designed as a dedicated dosing device to eliminate the need for dose conversion, as compared to use of the vial and syringe options, which some people may find to be an improvement." Until now, Humulin R U-500 was only available in a vial, administered with either a U-100 insulin syringe or a volumetric (tuberculin) syringe that requires conversion to respective syringe "unit markings" or volume markings. Although each U-500 KwikPen holds 1500 units of insulin (the amount in five U-100 insulin pens), it is the same size as other KwikPens and dials in five-unit increments. The U-500 KwikPen has a u Continue reading >>

Dailymed - Humulin R - Insulin Human Injection, Solution

THIS LILLY HUMAN INSULIN PRODUCT DIFFERS FROM ANIMAL-SOURCE INSULINS BECAUSE IT IS STRUCTURALLY IDENTICAL TO THE INSULIN PRODUCED BY YOUR BODY'S PANCREAS AND BECAUSE OF ITS UNIQUE MANUFACTURING PROCESS. ANY CHANGE OF INSULIN SHOULD BE MADE CAUTIOUSLY AND ONLY UNDER MEDICAL SUPERVISION. CHANGES IN STRENGTH, MANUFACTURER, TYPE (E.G., REGULAR, NPH, ANALOG), SPECIES, OR METHOD OF MANUFACTURE MAY RESULT IN THE NEED FOR A CHANGE IN DOSAGE. SOME PATIENTS TAKING HUMULIN (HUMAN INSULIN, rDNA ORIGIN) MAY REQUIRE A CHANGE IN DOSAGE FROM THAT USED WITH OTHER INSULINS. IF AN ADJUSTMENT IS NEEDED, IT MAY OCCUR WITH THE FIRST DOSE OR DURING THE FIRST SEVERAL WEEKS OR MONTHS. Insulin is a hormone produced by the pancreas, a large gland that lies near the stomach. This hormone is necessary for the body's correct use of food, especially sugar. Diabetes occurs when the pancreas does not make enough insulin to meet your body's needs. To control your diabetes, your doctor has prescribed injections of insulin products to keep your blood glucose at a near-normal level. You have been instructed to test your blood regularly for glucose. Studies have shown that some chronic complications of diabetes such as eye disease, kidney disease, and nerve disease can be significantly reduced if the blood sugar is maintained as close to normal as possible. Proper control of your diabetes requires close and constant cooperation with your doctor. Despite diabetes, you can lead an active and healthy life if you eat a balanced diet, exercise regularly, and take your insulin injections as prescribed by your doctor. Always keep an extra supply of insulin as well as a spare syringe and needle on hand. Always wear diabetic identification so that appropriate treatment can be given if complications occur away from Continue reading >>

Conversion Chart For Humulin R U-500 Insulin Dose

When using a U-100 insulin syringe or a tuberculin syringe, use this handy U-500 Conversion Chart. Humulin U-500 Conversion Chart Mar 2011 Continue reading >>