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Humulin R 500 Vial

Humulin R (u-500) (insulin Human) Dose, Indications, Adverse Effects, Interactions... From Pdr.net

Humulin R (u-500) (insulin Human) Dose, Indications, Adverse Effects, Interactions... From Pdr.net

Concentrated Insulins with Short and Intermediate Actions Hormone secreted by pancreatic beta-cells of the islets of Langerhans; essential for the metabolism and homeostasis of carbohydrate, fat, and protein Regular insulin 100 units/mL is a "short-acting" insulin; concentrated regular insulin 500 units/mL exhibits different pharmacokinetics Used for the treatment of diabetes mellitus type 1 and type 2; also used for blood glucose management due to hyperglycemia in critical care and other care settings Injectable regular insulin is available in 2 concentrations: 100 units/mL and 500 units/mL; clinicians and patients must ensure that the correct concentration is used to avoid severe overdose and hypoglycemia Humulin R, Novolin R, ReliOn, Velosulin BR Humulin R Subcutaneous Inj Sol Conc: 1mL, 500U Humulin R/Novolin R Subcutaneous Inj Sol: 1mL, 100U For the treatment of type 1 diabetes mellitus or for type 2 diabetes mellitus inadequately managed by diet, exercise, and oral hypoglycemics. When used for intermittent subcutaneous injection, the total daily dose is given as 2 to 4 injections per day, typically administered 30 to 60 minutes before meals; or administer as a sliding scale based on blood glucose monitoring several times per day. Regular U-500 insulin has a longer duration of action (up to 24 hours) compared to regular 100 units/mL, and is usually administered 2 to 3 times per day; regular 100 units/mL is usually administered 3 or more times per day and may also be used in combination with oral antihyperglycemic agents or longer-acting insulin products. A common regimen is to give an intermediate insulin (NPH or Lente) and regular insulin concomitantly and give two injections per day. About 2/3 of the daily insulin dose is given before breakfast and about 1/3 is Continue reading >>

First-ever Study Of Lilly's Humulin R U-500 Administered In An Insulin Pump Shows Improved A1c In People With Type 2 Diabetes

First-ever Study Of Lilly's Humulin R U-500 Administered In An Insulin Pump Shows Improved A1c In People With Type 2 Diabetes

First-ever Study of Lilly's Humulin R U-500 Administered in an Insulin Pump Shows Improved A1C in People with Type 2 Diabetes Study Results Evaluating Humulin R U-500 in Insulet Corporation's Omnipod U-500 Insulin Management System Presented at the American Diabetes Association 78th Scientific Sessions INDIANAPOLIS, June 25, 2018 /PRNewswire/ --Eli Lilly and Company's ( LLY ) Humulin R U-500 administered via an investigational insulin pump (Omnipod U-500 Insulin Management System) provided greater A1C reduction with less daily insulin needed compared to multiple daily injections (MDI) in adults with type 2 diabetes on high dose insulin (201-600 units/day).1 Data from this phase 3 study will be presented for the first time today in an oral session at the American Diabetes Association (ADA) 78th Scientific Sessions in Orlando. HumulinR U-500 is Lilly's highly concentrated insulin formulation that is used to control high blood sugar in people with diabetes who are insulin-resistant and need daily doses of more than 200 units of insulin. "Concentrated insulins are effective treatment options for people with diabetes who have high insulin requirements," said Tom Hardy, senior medical director at Lilly. "People who prefer to use an insulin pump currently do not have an option specifically for Humulin R U-500, which is five-times concentrated. These data show that Humulin R U-500 delivered with this investigational pump may help people better manage their blood sugar levels." At the study's primary endpoint of 26 weeks, Humulin R U-500 delivered in the investigational pump and through MDI led to A1C reductions from baseline in people with type 2 diabetes (-1.27 percent, -0.85 percent, respectively). Beginning at week eight through the duration of the study, A1C improvement wa Continue reading >>

Using U-500 Insulin

Using U-500 Insulin

What is it? Humulin R U-500 is a kind of insulin that is much stronger than the more common U-100 insulin. It is used by people with diabetes who need large doses of insulin, usually because they are “insulin resistant.” That means their bodies can't use insulin well, so they need large doses to keep their blood glucose (sugar) under control. How is it used? U-500 is 5 times more concentrated than U-100 insulin. This means that every 1 unit of U-500 is the same as 5 units of your usual insulin. This makes it a more powerful medicine. It also means that you need to be careful about giving yourself the right amount of U-500. If you are using a regular insulin syringe like the kind used for U-100 insulin, the markings each correspond to one-fifth of a U-500 unit. So, if you are taking 100 units of U-500 in an insulin syringe, you would draw insulin from the vial up to the 20 mark (100 ÷ 5 = 20). Your health care provider might want you to use a different kind of syringe, called a “tuberculin syringe.” This kind of syringe is marked in milliliters (ml). If you are taking 100 units of U-500 in a tuberculin syringe, you would draw insulin from the vial up to the 0.2-ml mark. (See chart at left.) Check your insulin before you leave the pharmacy to be sure you have the right kind. U-500 insulin comes in 20-ml vials (twice as big as U-100 insulin vials) and has orange stripes on the box and label. Make sure you are also using the correct syringes. Your health care provider will tell you whether to use the usual insulin syringes or to switch to tuberculin syringes. Don't hesitiate to ask your prescriber or pharmacist any questions you may have about U-500. It can be confusing at first to make the switch, but your health care team is there to help you. Preventing lows Ins Continue reading >>

What Are The Possible Side Effects Of Concentrated Insulin (humulin R (concentrated))?

What Are The Possible Side Effects Of Concentrated Insulin (humulin R (concentrated))?

A A A Medications and Drugs Brand Names: Humulin R (Concentrated) Generic Name: insulin regular, concentrated (U-500) (Pronunciation: IN soo lin) What is the most important information I should know about concentrated insulin (Humulin R (Concentrated))? What should I discuss with my healthcare provider before using concentrated insulin (Humulin R (Concentrated))? What is concentrated insulin (Humulin R (Concentrated))? Concentrated insulin is a man-made form of a hormone that is produced in the body. It works by lowering levels of glucose (sugar) in the blood. Concentrated insulin (U-500) is a long-acting form of insulin that is different from other forms that are made from animal insulin. Concentrated insulin is used to treat type 1 (insulin-dependent) diabetes in people with significant daily insulin needs (more than 200 units per day). Concentrated insulin may also be used for purposes other than those listed in this medication guide. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tell your doctor if you have any pain, redness, swelling, or skin changes where the insulin was injected. Low blood sugar is the most common side effect of concentrated insulin. Symptoms of low blood sugar may include headache, nausea, hunger, confusion, drowsiness, weakness, dizziness, blurred vision, fast heartbeat, sweating, tremor, trouble concentrating, confusion, seizure (convulsions), or death. Watch for signs of low blood sugar. This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088. What is the most important information I should know about concen Continue reading >>

U-500 Insulin Errors

U-500 Insulin Errors

Humulin R is the brand name for Eli Lilly's recombinant human regular insulin. The usual version of Humulin R is U-100 and contains 100 units of insulin activity per 1 milliliter of fluid. But there's also a rarely-used version called U-500. The U-500 insulin is 5 times more potent than U-100 insulin. U-500 insulin contains 500 units of insulin activity per 1 milliliter of fluid. People may need to use U-500 if their diabetes is not well-controlled with U-100. The U-500 version should be used only for patients requiring doses above 200 units a day. Important information about U-500 insulin Since the use of U-500 insulin is not as common as the use of U-100 insulin, some health professionals may not be aware of it. This by itself increases the chance of dispensing errors. The main problem with U-500 insulin is the risk of a mix-up between the insulin U-100 and insulin U-500 versions. If this occurs, it can result in very dangerous low blood sugar or very high blood sugar. A mix-up between the two insulin concentrations may occur if doctors or pharmacists select the wrong concentration (for example, selecting the U-500 regular insulin from computer screen instead of U-100). Sometimes the two concentrations appear one line apart on the computer screen, which sets up the possibility of selection errors. Depending on the screen size, the prescriber may see only the first few words of the product listing, so the drug concentration is not seen. Prescribers may assume the patient needs U-100 and may not even look for the concentration on the screen. A mix-up may also occur if U-100 insulin and U-500 insulin are stored next to each other at the pharmacy, in the hospital or even in your home. Although the colors of the vials are different, if someone is not aware to look out for Continue reading >>

First-ever Study Of Lilly's Humulin R U-500 Administered In An Insulin Pump Shows Improved A1c In People With Type 2 Diabetes

First-ever Study Of Lilly's Humulin R U-500 Administered In An Insulin Pump Shows Improved A1c In People With Type 2 Diabetes

First-ever Study of Lilly's Humulin R U-500 Administered in an Insulin Pump Shows Improved A1C in People with Type 2 Diabetes Study Results Evaluating Humulin R U-500 in Insulet Corporation's Omnipod U-500 Insulin Management System Presented at the American Diabetes Association 78th Scientific Sessions INDIANAPOLIS, June 25, 2018 /PRNewswire/ --Eli Lilly and Company's (NYSE: LLY ) Humulin R U-500 administered via an investigational insulin pump (Omnipod U-500 Insulin Management System) provided greater A1C reduction with less daily insulin needed compared to multiple daily injections (MDI) in adults with type 2 diabetes on high dose insulin (201-600 units/day).1 Data from this phase 3 study will be presented for the first time today in an oral session at the American Diabetes Association (ADA) 78th Scientific Sessions in Orlando. HumulinR U-500 is Lilly's highly concentrated insulin formulation that is used to control high blood sugar in people with diabetes who are insulin-resistant and need daily doses of more than 200 units of insulin. "Concentrated insulins are effective treatment options for people with diabetes who have high insulin requirements," said Tom Hardy, senior medical director at Lilly. "People who prefer to use an insulin pump currently do not have an option specifically for Humulin R U-500, which is five-times concentrated. These data show that Humulin R U-500 delivered with this investigational pump may help people better manage their blood sugar levels." At the study's primary endpoint of 26 weeks, Humulin R U-500 delivered in the investigational pump and through MDI led to A1C reductions from baseline in people with type 2 diabetes (-1.27 percent, -0.85 percent, respectively). Beginning at week eight through the duration of the study, A1C improveme Continue reading >>

Humulin U-500: Counseling Your Patients

Humulin U-500: Counseling Your Patients

Pharmacists looking to counsel patients on Humulin R U-500 can use counseling points that are very similar to U-100, which patients often find comforting. To begin with the product, which is a concentrated insulin that is typically considered in patients injecting large volumes of U-100, should be clear and colorless at all times. They should be administering the insulin 30 minutes before their meal(s). The most common adverse effect reported with Humulin R U-500 is hypoglycemia. Studies show that patients are at risk for severe hypoglycemia as long as 18-24 hours post injection and should always be considered a risk factor if the patient is found unresponsive. For this reason patients should also be cautious while driving/operating heavy machinery at all times, but especially when first starting this medication as well as any dose changes. To minimize the risk of hypoglycemia, Humulin R U-500 should not be administered IV, IM, or via insulin pump in a hospital setting or outpatient. Other common adverse effects would include lipodystrophy, weight gain, edema, allergic reactions, and/or immunogenicity (antibody formulation). Considered a Pregnancy Category B, this product, like other insulin products should be used in pregnant women with both caution and care but it is noteworthy that Humulin R U-500 does not pose any greater risk. The insulin does pass into the breast milk and gets ingested by the infant, however, the insulin is broken down into the gastrointestinal tract and does not raise any concern, therefore, it is safe to administer while breastfeeding. Commercially available as both a KwikPen and vials, the KwikPens are 3 mL and contain 1,500 units in each pen availablein packs of 2 and 3 pens, while the vials are available as 20 mL containing 10,000 units of i Continue reading >>

Humulin R U-500 Vial

Humulin R U-500 Vial

Uses Concentrated insulin regular is used with a proper diet and exercise program to control high blood sugar in people with diabetes who require large doses of insulin (more than 200 units per day). Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. This man-made insulin product is the same as human insulin. It replaces the insulin that your body would normally make. It works right away like regular insulin but its effects last longer. It works by helping blood sugar (glucose) get into cells so your body can use it for energy. This medication may be used alone or with other oral diabetes drugs (such as metformin). How to use Humulin R U-500 Vial Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor, diabetes educator, or pharmacist. This insulin product is a high-strength concentrated liquid. Learn all preparation and usage instructions from your health care professional and the product package. If you are using the vial, use the proper syringe prescribed by your doctor to make sure you are measuring the correct dose. Before using, check this product visually for particles or discoloration. If either is present, do not use the insulin. This insulin product should be clear and colorless. Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin and to avoid developing problems under the skin (lipodystrophy). This insulin product may be injected in the stomach area, the thigh, the buttocks, or the back of t Continue reading >>

Humulin R U-500 Vial

Humulin R U-500 Vial

I use humulin r u 500 vial 20ml . When I went to a restaurant with my family i went to the restroom so I can take my insulin shot the vial broke and I dont have a extra one. So I try to get a refill the pharmacy said it was too soon. If I wanted one I will have to paid $1,471.00 for one vial. I have the money for this insulin and I have medicare part A and Breakfast and part Chicago and part D and I have extra help to paid for my medications. So what I did I called the company it made sense humulin r u 500 on Friday. I will find out tomorrow on what they are doing to do? @Marie17 : we broke a vial once and called our insurance right away - they allowed the purchase of an extra vial because of accidental damage. So my first suggestion is to call the insurance company first thing tomorrow morning to see if they will allow a refill due to accidental damage. I am not familiar with Medicare etc. so I am not sure who to call. Please dont spend all that money without first trying to talk to the insurance. I hope someone can help with more specific information. I would start calling first thing in the morning. I would also call my doctors office to ask what they can do. Possibly they can give you a prescription for a slightly different insulin that would still work for you but that your insurance will accept to pay for. Another path, but much more expensive: I believe that Humulin R may be the same formula as ReliOn Regular, sold at Walmart for much cheaper, and without the need for a prescription, although NOT in concentrated form. If you find out that these two insulin correspond, and if you can make do with using the non-concentrated form, I believe that a Regular 3ml vial costs about $25. A 5x concentrated 20ml vial is equivalent to 100 ml of non-concentrated insulin Regul Continue reading >>

Humulin R U-500 Prescription Price Comparison | Compare Drug Prices | Scriptsave Wellrx

Humulin R U-500 Prescription Price Comparison | Compare Drug Prices | Scriptsave Wellrx

ScriptSave WellRx is brought to you by Medical Security Card Company, LLC , the trusted prescription discount leader at more than 62,000 pharmacies nationwide. See our online .Pharmacy certification . Compare Pharmacy Prescription Drug Prices ScriptSave WellRx is the smart and trusted resource that makes prescription medicines more affordable and easier to manage, because ScriptSave WellRx cares about helping people stay healthy. ScriptSave WellRx is free to join , and we're accepted nationwide at more than 62,000 pharmacies. Enter the prescription drugs you are searching for along with your address or zip code and compare pharmacy prices to find the best prescription drug prices in your area. You can also download our app and use its functionality on the go. How does the ScriptSave WellRx Card work? Simply present your ScriptSave WellRx card at any of the thousands of participating pharmacies nationwide to receive your instant savings. It's that easy! Just show your card to the pharmacist each time you pick up your prescription, whether you're filling for the first time or refilling. There is no paperwork to complete and no limit on usage. How much will I save with the ScriptSave WellRx card? Savings average 54%, and, in some cases, can be 80% or more.* Savings vary based upon the medication and the pharmacy you choose to use. Start saving big on all of your medicine needs with ScriptSave WellRx. Do all pharmacies accept the ScriptSave WellRx Card? ScriptSave WellRx is accepted at 62,000 participating chain and independent retail pharmacies nationwide, so there's likely a participating pharmacy nearby. Chances are, the pharmacy you use now participates. For more answers to Frequently Asked Questions, visit our FAQs page. * Average and up to savings percentages are bas Continue reading >>

Calculating Concentrated Insulins

Calculating Concentrated Insulins

by Jennifer N. Clements, PharmD, BCPS, CDE, BCACP | Sep 06, 2016 ecently, representatives from Eli Lilly came to the school of pharmacy to educate faculty and fourth-year professional students on concentrated insulin, such as Humalog (insulin lispro U-200) and Humulin R (insulin regular U-500). While I was listening to the speaker talk about the devices, I reflected on how much diabetes has changed over the years. When I was in pharmacy school studying diabetes in the fall of 2004, the faculty member taught us about metformin, sulfonylureas, acarbose, rosiglitazone, and pioglitazone. She also mentioned insulins that were available such as NPH, regular insulin and others. At this time, I never had to calculate a U-500 dose. As a faculty member for the past 10 years, I would speak to fourth-year professional students on my ambulatory care learning experience about concentrated insulins in order to make them aware about the potential opportunity of dispensing and/or counseling on these medications when they become an independent pharmacist. With the new concentrated insulin pens, it is essential to educate students about these options because as it may be that the use of concentrated insulin increases over the next couple of years. It is important to remember that there are other concentrated insulins on the market, such as Toujeo (insulin glargine U-300) and Tresiba (insulin degludec U-200). Keep in mind that everyone may have different approaches depending on the experience and comfort level with U-500 insulin. After the discussion on these two specific products, the students wanted to review how to calculate Humulin R U-500 from U-100 insulin, but they also specifically wanted clarification on the dose from a vial or the pre-filled pen. Here is an example of the calcul Continue reading >>

Humulin R U-500

Humulin R U-500

Generic Name: insulin human Dosage Form: injection, solution Indications and Usage for Humulin R U-500 HUMULIN R U-500 is a concentrated human insulin indicated to improve glycemic control in adult and pediatric patients with diabetes mellitus requiring more than 200 units of insulin per day. Limitation of Use The safety and efficacy of HUMULIN R U-500 used in combination with other insulins has not been determined. The safety and efficacy of HUMULIN R U-500 delivered by continuous subcutaneous infusion has not been determined. Humulin R U-500 Dosage and Administration Important Administration Instructions Prescribe HUMULIN R U-500 ONLY to patients who require more than 200 units of insulin per day. Humulin R U-500 is available as a KwikPen or multiple dose vial. Patients using the vial must be prescribed the U-500 insulin syringe to avoid medication errors. Instruct patients using the vial presentation to use only a U-500 insulin syringe and on how to correctly draw the prescribed dose of HUMULIN R U-500 into the U-500 insulin syringe. Confirm that the patient has understood these instructions and can correctly draw the prescribed dose of HUMULIN R U-500 with their syringe [see Dosage and Administration (2.4) and Warnings and Precautions (5.1)]. Advise the patient to read the FDA-approved patient labeling (Patient Information and Instructions for Use). Train patients on proper use and injection technique before initiating HUMULIN R U-500. Training reduces the risk of administration errors such as needle sticks and dosing errors. Instruct patients to always check the insulin label before administration to confirm the correct insulin product is being used [see Warnings and Precautions (5.1)]. Inspect HUMULIN R U-500 visually for particulate matter and discoloration. Only Continue reading >>

Indication For Humulin R U-500

Indication For Humulin R U-500

If your A1C is uncontrolled on high doses of standard insulin—more than 200 units a day—you may have another diabetes treatment option. Humulin® R U-500 is 5x concentrated insulin* available in a U-500 KwikPen® or syringe and vial. U-500 lowered high blood sugar in a clinical study. † If your doctor has prescribed U-500 for you or a loved one, learn more here. † 24 week, open-label, randomized trial to compare the efficacy and safety of 2 dosing regiments (TID, n=162 vs BID, n=163) for U-500 insulin replacing high dose U-100 insulin (>200 units per day) with or without oral antihyperglycemic drugs in adult patients with uncontrolled type 2 diabetes. These regimens were found to be equivalent for A1C reduction over 24 weeks, and both were efficacious. Study conducted with U-100 insulin syringes and Humulin R U-500 vials. Continue reading >>

U-500 Insulin: Not For Ordinary Use

U-500 Insulin: Not For Ordinary Use

US Pharm. 2010;35(5)(Diabetes suppl):14-17. If not already seeing them, pharmacists should anticipate encountering prescriptions for U-500 regular insulin. U-500 insulin is five times more potent than standard U-100 and is utilized in patients requiring high doses of insulin. Prescribing of U-500 is on the rise due to the obesity epidemic, adoption of tighter glucose control protocols, increased insulin resistance, and utilization of insulin pumps.1 Potential for adverse drug events exists due to unfamiliarity with U-500 and its higher potency. This review is intended to enable safe provision of U-500 insulin by increasing awareness of the drug and its correct administration. As insulin resistance worsens, greater doses of insulin are required to meet glycemic goals. This is especially true for persons with insulin resistance (IR) syndromes. These are patients with an insulin requirement of 200 U/day and greater. FIGURE 1 illustrates the body’s response to insulin as the dose increases. Note that for patients with IR syndromes, the dose response to insulin is significantly diminished. This is especially true when insulin doses exceed 100 U. However, this phenomenon does not mean greater doses are without effect.2 In fact, higher doses of insulin eventually achieve therapeutic targets. For this reason, use of high-dose insulin should not be avoided in insulin-resistant patients. Otherwise, these patients will fail to achieve glycemic goals by underdosing insulin. Use of standard insulin becomes problematic when patients require over 200 U/day or greater than 100 U per injection. At these doses, the volume of U-100 insulin is physically too large for single subcutaneous administration, and multiple injections are required to deliver a single dose. With more injections, Continue reading >>

Indication For Humulin R U-500

Indication For Humulin R U-500

What is the most important information I should know about Humulin R U-500? Do not share your Humulin R U-500 KwikPen or U-500 insulin syringes with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them. Do not take Humulin R U-500 if your blood sugar is too low (hypoglycemia) or you are allergic to any of the ingredients in Humulin R U-500. Tell your healthcare provider: If you have liver, kidney, or heart problems or any other medical conditions. If you are pregnant, plan to become pregnant, or are breast-feeding. About all the medicines you take, including prescription (especially ones commonly called TZDs [thiazolidinediones]) and over the counter medicines, vitamins, and herbal supplements. Before you start using Humulin R U-500, talk to your healthcare provider about low blood sugar and how to manage it. Take Humulin R U-500 exactly as your healthcare provider tells you to. Your healthcare provider should show you how much Humulin R U-500 to use and when to use it. Check your insulin label each time you give your injection to make sure you are using the correct insulin. Humulin R U-500 KwikPen: The U-500 KwikPen is specially made to dial and deliver doses of Humulin R U-500 insulin. Do not use any syringe to remove Humulin R U-500 insulin from your U-500 KwikPen. The markings on certain syringes will not measure your dose correctly. A severe overdose can happen, causing low blood sugar, which may put your life in danger. Humulin R U-500 vial: There is a special U-500 insulin syringe to measure Humulin R U-500. Use only a U-500 insulin syringe to draw up and inject your Humulin R U-500. If you do not use the right syringe type, you may take the wrong dose of Humulin R U-500. This can ca Continue reading >>

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