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Humulin Interactions

Interactions Of Short-acting, Intermediate-acting And Pre-mixed Human Insulins With Free Radicals--comparative Epr Examination.

Interactions Of Short-acting, Intermediate-acting And Pre-mixed Human Insulins With Free Radicals--comparative Epr Examination.

Abstract Electron paramagnetic resonance (EPR) spectroscopy was used to examine insulins interactions with free radicals. Human recombinant DNA insulins of three groups were studied: short-acting insulin (Insuman Rapid); intermediate-acting insulins (Humulin N, Insuman Basal), and pre-mixed insulins (Humulin M3, Gensulin M50, Gensulin M40, Gensulin M30). The aim of an X-band (9.3GHz) study was comparative analysis of antioxidative properties of the three groups of human insulins. DPPH was used as a stable free radical model. Amplitudes of EPR lines of DPPH as the paramagnetic free radical reference, and DPPH interacting with the individual tested insulins were compared. For all the examined insulins kinetics of their interactions with free radicals up to 60 min were obtained. The strongest interactions with free radicals were observed for the short-acting insulin - Insuman Rapid. The lowest interactions with free radicals were characteristic for intermediate-acting insulin - Insuman Basal. The pre-mixed insulins i.e. Humulin M3 and Gensulin M50 revealed the fastest interactions with free radicals. The short acting, intermediate acting and premixed insulins have been found to be effective agents in reducing free radical formation in vitro and should be further considered as potential useful tools in attenuation of oxidative stress in diabetic patients. Continue reading >>

Regular-insulin, Injectable Solution

Regular-insulin, Injectable Solution

Insulin regular (human) injectable solution is available as brand-name drugs. It’s not available in a generic form. Brand names: HumuLIN R, NovoLIN R. Insulin regular (human) comes in three forms: injectable solution, powder for inhalation, and an intravenous injection. Insulin regular (human) injectable solution is used along with a healthy diet and exercise to control high blood sugar caused by type 1 or type 2 diabetes. Low blood sugar warning: Insulin regular (human) can cause low blood sugar (hypoglycemia). If you have a low blood sugar reaction, you’ll need to treat it right away. Symptoms can include: hunger dizziness shakiness lightheadedness sweating irritability headache fast heart rate confusion Thiazolidinedione warning: Taking certain diabetes pills called thiazolidinediones (TZDs) with insulin regular (human) may cause heart failure in some people. This can happen even if you’ve never had heart failure or heart problems before. If you already have heart failure, it may get worse. Your healthcare provider should monitor you closely while you’re taking TZDs with insulin regular (human). Tell your doctor right away if you have new or worse symptoms of heart failure, including: shortness of breath swelling of your ankles or feet sudden weight gain Infection warning: Do not share insulin vials, syringes or prefilled pens with other people. Sharing or reusing needles or syringes with another person puts you and others at risk for various infections. Insulin regular (human) is available as an over-the-counter (OTC) and prescription drug. It comes as a solution that you inject subcutaneously (under your skin). Your healthcare provider will show you how to give yourself the injection. You can also follow this guide for self-injection. Insulin regular (human Continue reading >>

Humulin R Regular U-100 Insulin Injection : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - Webmd

Humulin R Regular U-100 Insulin Injection : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - Webmd

Insulin regular is used with a proper diet and exercise program to control high blood sugar in people with diabetes . Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke . This man-made insulin product is the same as human insulin . It replaces the insulin that your body would normally make. It is a short-acting insulin. It works by helping blood sugar ( glucose ) get into cells so your body can use it for energy. This medication is usually used in combination with a medium- or long-acting insulin product. This medication may also be used alone or with other oral diabetes drugs (such as metformin ). Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor, diabetes educator, or pharmacist. Learn all preparation and usage instructions from your health care professional and the product package. Before using, check this product visually for particles or discoloration. If either is present, do not use the insulin . Insulin regular should be clear and colorless. Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin and to avoid developing problems under the skin ( lipodystrophy ). Insulin regular may be injected in the stomach area, the thigh, the buttocks, or the back of the upper arm. Do not inject into a vein or muscle because very low blood sugar ( hypoglycemia ) may occur. Do not rub the area after the injection. Do not inject into skin that is red, swollen, or itchy. Do not inject cold insulin because thi Continue reading >>

What Are The Possible Side Effects Of Concentrated Insulin (humulin R (concentrated))?

What Are The Possible Side Effects Of Concentrated Insulin (humulin R (concentrated))?

A A A Medications and Drugs Brand Names: Humulin R (Concentrated) Generic Name: insulin regular, concentrated (U-500) (Pronunciation: IN soo lin) What is the most important information I should know about concentrated insulin (Humulin R (Concentrated))? What should I discuss with my healthcare provider before using concentrated insulin (Humulin R (Concentrated))? What is concentrated insulin (Humulin R (Concentrated))? Concentrated insulin is a man-made form of a hormone that is produced in the body. It works by lowering levels of glucose (sugar) in the blood. Concentrated insulin (U-500) is a long-acting form of insulin that is different from other forms that are made from animal insulin. Concentrated insulin is used to treat type 1 (insulin-dependent) diabetes in people with significant daily insulin needs (more than 200 units per day). Concentrated insulin may also be used for purposes other than those listed in this medication guide. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tell your doctor if you have any pain, redness, swelling, or skin changes where the insulin was injected. Low blood sugar is the most common side effect of concentrated insulin. Symptoms of low blood sugar may include headache, nausea, hunger, confusion, drowsiness, weakness, dizziness, blurred vision, fast heartbeat, sweating, tremor, trouble concentrating, confusion, seizure (convulsions), or death. Watch for signs of low blood sugar. This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088. What is the most important information I should know about concen Continue reading >>

Humulin R

Humulin R

HUMULIN®R (regular insulin human) Injection, USP (rDNA Origin) 100 Units per ML (U-100) DESCRIPTION Humulin® R U-100 is a polypeptide hormone structurally identical to human insulin synthesized through rDNA technology in a special non-disease-producing laboratory strain of Escherichia coli bacteria. Humulin R (insulin human recombinant) U-100 has the empirical formula C257H383N65O77S6 and a molecular weight of 5808. Humulin R (insulin human recombinant) U-100 is a sterile, clear, aqueous, and colorless solution that contains human insulin (rDNA origin) 100 units/mL, glycerin 16 mg/mL and metacresol 2.5 mg/mL, endogenous zinc (approximately 0.015 mg/100 units) and water for injection. The pH is 7.0 to 7.8. Sodiumhydroxide and/or hydrochloric acid may be added during manufacture to adjust the pH. Adequate insulin dosage permits patients with diabetes to effectively utilize carbohydrates, proteins and fats. Regardless of dose strength, insulin enables carbohydrate metabolism to occur and thus to prevent the production of ketone bodies by the liver. Some patients develop severe insulin resistance such that daily doses of several hundred units of insulin or more are required. Continue reading >>

Humulin R Drug Interactions - Drugs.com

Humulin R Drug Interactions - Drugs.com

Do not stop taking any medications without consulting your healthcare provider. Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2018 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist. Some mixtures of medications can lead to serious and even fatal consequences. Continue reading >>

Insulin-injection, Humulin, Iletin I Nph, Novolin

Insulin-injection, Humulin, Iletin I Nph, Novolin

The display and use of drug information on this site is subject to express terms of use. By continuing to view the drug information, you agree to abide by such terms of use. INSULIN-INJECTION, Humulin, Iletin I NPH, Novolin GENERIC NAME: INSULIN - INJECTION (IN-sue-lin) BRAND NAME(S): Humulin, Iletin I NPH, Novolin HOW TO USE: Insulin must be injected. Learn the proper way to inject insulin. Check the dose carefully. Clean the injection site with rubbing alcohol. Change the injection site daily to prevent skin bulges or pockets. Do not inject cold insulin. The insulin container you are currently using can be kept at room temperature. The length of time you can store it at room temp. depends on the product. Consult your pharmacist. Insulin is frequently injected 30 minutes before a meal. Some inject at bedtime. Ask your pharmacist or nurse for details of injecting insulin as it varies depending on your insulin treatment plan. Monitor your urine or blood sugar as prescribed. Keep track of your results. This is very important in order to determine the correct insulin dose. Follow all of your doctor's directions carefully. Type 2 Diabetes Diagnosis, Treatment, Medication SIDE EFFECTS: Insulin may cause minor and usually temporary side effects such as rash, irritation or redness at the injection site. To help prevent hypoglycemia, eat meals on a regular schedule. Too much insulin can cause low blood sugar (hypoglycemia). The symptoms include cold sweat, shaking, rapid heart rate, weakness, headache and fainting which, if untreated, may lead to slurred speech and other behaviors that resemble drunkenness. If you experience these symptoms, eat a quick source of sugar such as glucose (glutose, etc.) table sugar, orange juice, honey or non-diet soda. Tell your doctor about the r Continue reading >>

What Is Humulin R (insulin Regular)?

What Is Humulin R (insulin Regular)?

Humulin R is the brand name of a medicine that contains insulin regular (a short-acting form of insulin). Insulin is a hormone that's produced by the body in the pancreas. It works to lower levels of sugar in the blood. This prescription medicine is injected to improve blood sugar control in adults with diabetes. The U.S. Food and Drug Administration (FDA) first approved human insulin in 1982. Humulin R is marketed by Ely Lilly and Company. Humulin R Warnings Humulin R shouldn't be used during an episode of hypoglycemia (low blood sugar). Low blood sugar is a common side effect of insulin. Symptoms may include: Hunger Headache Weakness Sweating Irritability Tremors Trouble concentrating Fast heartbeat Fainting Seizures Look out for signs of low blood sugar, and carry candy or glucose tablets in case you have an episode. You may also experience signs of hyperglycemia (high blood sugar), which often include: Hunger Increased thirst Dry mouth Fruity breath odor Dry skin Blurred vision Weight loss Increased urination Drowsiness You'll need to monitor your blood sugar levels often while taking this medicine. It's important that you keep Humulin R with you at all times. Be sure to get your prescription refilled before you run out of this medicine. Don't change the brand of insulin or type of syringe you're using without first talking to your healthcare provider. They may not be interchangeable. Before taking Humulin R, tell your doctor if you have, or have ever had: Kidney or liver disease Heart failure, or other heart problems Nerve, adrenal, pituitary, or thyroid problems Eye problems caused by diabetes Allergies to medications Let your doctor know about all the medicines you're taking while using Humulin R, especially certain oral diabetes drugs, such as Actos (pioglitazon Continue reading >>

Humulin 70/30 Drug Interactions

Humulin 70/30 Drug Interactions

Diabetes Home > Humulin 70/30 Drug Interactions When you take fibrate cholesterol medications, monoamine oxidase inhibitors (MAOIs), or ACE inhibitors in combination with Humulin 70/30, drug interactions could occur. These interactions may increase the risk of low blood sugar, which can become dangerous quickly. To help minimize drug interactions, be sure to check with your healthcare provider any time you start, stop, or change the dose of any medication. Insulin medications, including Humulin 70/30 (NPH insulin/ regular insulin ), can potentially interact with numerous different medications. In fact, any medication that has the potential to affect your blood sugar can also interact with Humulin 70/30 . Because there are so many potential Humulin 70/30 interactions (and because some are relatively insignificant), this article does not discuss every possible interaction. Some interactions may increase blood sugar levels, which is not healthy but is usually not immediately dangerous. Typically, most people will notice higher blood sugar (when testing) and will adjust their insulin dosage as recommended by their healthcare provider long before these interactions become dangerous. These interactions are not discussed in this article. However, other Humulin 70/30 drug interactions can result in dangerously low blood sugar levels (known medically as hypoglycemia). These interactions can potentially be dangerous (even fatal) rather quickly, even if you check your blood sugar regularly. Some of the medicines that may cause dangerously low blood sugar when combined with Humulin 70/30 include: Angiotensin-converting enzyme inhibitors ("ACE inhibitors"), such as: Continue reading >>

What Is Humulin 70/30 Kwikpen?

What Is Humulin 70/30 Kwikpen?

Before you receive DARZALEX®, tell your healthcare provider about all of your medical conditions, including if you: have a history of breathing problems have had shingles (herpes zoster) are pregnant or plan to become pregnant. DARZALEX® may harm your unborn baby. Females who are able to become pregnant should use an effective method of birth control during treatment and for at least 3 months after your final dose of DARZALEX®. Talk to your healthcare provider about birth control methods that you can use during this time. are breastfeeding or plan to breastfeed. It is not known if DARZALEX® passes into your breast milk. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. DARZALEX® may be given alone or together with other medicines used to treat multiple myeloma. Your healthcare provider will decide the time between doses as well as how many treatments you will receive. Your healthcare provider will give you medicines before each dose of DARZALEX® and on the first day after each dose of DARZALEX® to help reduce the risk of infusion reactions. If you miss any appointments, call your healthcare provider as soon as possible to reschedule your appointment. Infusion reactions. Infusion reactions are common with DARZALEX® and can be severe. Your healthcare provider may temporarily stop your infusion or completely stop treatment with DARZALEX® if you have infusion reactions. Tell your healthcare provider right away if you get any of the following symptoms: shortness of breath or trouble breathing dizziness or lightheadedness (hypotension) cough wheezing throat tightness runny or stuffy nose headache itching nausea vomiting chills fever Changes in blood tests. DARZALEX Continue reading >>

Humulin N And Humulin R Drug Interactions - Drugs.com

Humulin N And Humulin R Drug Interactions - Drugs.com

Do not stop taking any medications without consulting your healthcare provider. Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2018 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist. Some mixtures of medications can lead to serious and even fatal consequences. Continue reading >>

Insulin Regular Human (rx, Otc)

Insulin Regular Human (rx, Otc)

Dosage Forms & Strengths injectable solution Type 1 Diabetes Mellitus Initial: 0.2-0.4 units/kg/day SC divided q8hr or more frequently Maintenance: 0.5-1 unit/kg/day SC divided q8hr or more frequently; in insulin-resistant patients (eg, due to obesity), substantially higher daily insulin may be required Approximately 50-75% of the total daily insulin requirements are given as intermediate- or long-acting insulin administered in 1-2 injections; rapid- or short-acting insulin should be used before or at mealtimes to satisfy the remainder balance of the total daily insulin requirements Premixed combinations are available that deliver rapid- or short-acting components at the same time as the intermediate- or long-acting component Type 2 Diabetes Mellitus Type 2 diabetes inadequately controlled by diet, exercise, or oral medication: Suggested beginning dose of 10 units/day SC (or 0.1-0.2 unit/kg/day) in evening or divided q12hr Severe Hyperglycemia (Diabetic Ketoacidosis) 0.1 unit/kg/hr IV continuous infusion; if serum glucose does not fall by 50 mg/dL in the first hour, check hydration status; if possible, double the insulin hourly until glucose levels fall at the rate of 50-75 mg/dL/hr; decrease infusion to 0.05-0.1 unit/kg/hour when blood sugar reaches 250 mg/dL Dosing Considerations Dosage of human insulin, which is always expressed in USP units, must be based on the results of blood and urine glucose tests and must be carefully individualized to optimal effect Dose adjustments should be based on regular blood glucose testing Adjust to achieve appropriate glucose control Look for consistent pattern in blood sugars for >3 days Same time each day: Compare blood glucose levels with previous levels found at that time of day For each time of day: Calculate blood glucose range Continue reading >>

Humulin 70/30 (insulin, Human) Dosage, Indication, Interactions, Side Effects | Empr

Humulin 70/30 (insulin, Human) Dosage, Indication, Interactions, Side Effects | Empr

Insulin isophane suspension (NPH) 70% (human, rDNA origin), regular insulin 30% (human, rDNA origin) 100 Units/mL; inj. SC injection only. Onset approx 30 mins, peak 212hrs, duration up to 24hrs. Instruct patients on diet, exercise, blood or urine testing, proper administration of insulin, change in species of origin, type or purity of insulin, and management of hypoglycemia. Do not reuse or share pens, needles, or syringes between patients. Dosage increase may be required during infection, illness, stress, trauma, and pregnancy. Dosage decrease may be needed with renal or hepatic dysfunction. Concomitant thiazolidinediones (TZDs) may cause fluid retention and heart failure; consider dose reduction or discontinue TZDs. Potentiated by oral antidiabetic agents, pramlintide, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, propoxyphene, salicylates, somatostatin analog, sulfonamide antibiotics. Antagonized by corticosteroids, isoniazid, niacin, danazol, diuretics, thiazides, phenothiazines, sympathomimetics, somatropin, thyroid hormones, estrogens, progestogens, atypical antipsychotics. Variable effects with -blockers, clonidine, lithium salts, alcohol, pentamidine. Onset may be delayed if regular insulin is mixed with zinc insulin. Regular and NPH insulins may be mixed and used immediately or stored for future use. Hypoglycemia, hypokalemia, local or systemic allergy, lipodystrophy, edema. Vials 70/30, N, R (U-100)10mL; R (U-500)20mL; KwikPen (70/30, N)5x3mL; R (U-500)2x3mL, 5x3mL Continue reading >>

Humulin 70/30 Drug Interactions - Drugs.com

Humulin 70/30 Drug Interactions - Drugs.com

Do not stop taking any medications without consulting your healthcare provider. Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2018 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist. Some mixtures of medications can lead to serious and even fatal consequences. Continue reading >>

Humulin N Drug Interactions - Drugs.com

Humulin N Drug Interactions - Drugs.com

Do not stop taking any medications without consulting your healthcare provider. Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2018 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist. Some mixtures of medications can lead to serious and even fatal consequences. Continue reading >>

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