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Humalog Vs Novolog

Humalog Vs. Novolog: What’s The Difference?

Humalog Vs. Novolog: What’s The Difference?

The two leaders in the fast acting insulin market, Humalog and Novolog, are the most common types of fast acting insulin used by those with diabetes today. Fast Acting, mealtime insulin is a type of insulin that is injected before or right after eating. When you eat your blood glucose begins to rise. Fast acting insulin, Humalog and Novolog work to help manage these rises or spikes to keep your blood glucose levels more within range and balanced. When you use a fast acting insulin like Humalog or Novolog, you typically will continue to take a long acting insulin to help manage your levels between your meals and throughout the night. The question is though, is there really a difference between the two? Endocrinologists and other medical professionals don’t seem to really think there is, stating the two are virtually interchangeable. But that’s not really the full story. Humalog (Insulin Lispro) Insulin Lispro (Humalog) has been on the market since 1996, when it was first introduced by Eli Lily. Humalog is the first insulin analogue that was used clinically. Insulin Lispro received its name due to its structure. The difference between it and regular insulin was the switch between the lysine B28 (an amino acid) and proline B29. The formula consists of a hexametric solution available in vials and pen form. After a subcutaneous injection, the formula converts into a monomeric formula which allows it to have a fast absorption in the body. The one noted negative factor of Humalog is its short term control of glucose levels. Additionally, if it is injected and mealtime happens to be delayed, a hypoglycemic episode may occur. For Humalog to be most effective it is to be injected 15 minutes prior to the start of a meal. I recommend reading the following articles: Humalog is a Continue reading >>

An Inhaled Insulin (afrezza)

An Inhaled Insulin (afrezza)

The FDA has approved an inhaled, rapid-acting, dry-powder formulation of recombinant human insulin (Afrezza – Mannkind/Sanofi) for treatment of adults with type 1 or type 2 diabetes. In patients with type 1 diabetes, the drug must be used in combination with long-acting insulin. Another inhaled, rapid-acting insulin (Exubera) was approved in 2006 for the same indication, but was withdrawn from the market the following year.1 RAPID-ACTING INSULINS — Rapid-acting insulin analogs have a faster onset and shorter duration of action than regular insulin and are generally administered just before, at the start of, or soon after a meal. In addition to being more convenient, these drugs appear to be slightly more effective than regular insulin in decreasing HbA1c, with less hypoglycemia.2 Three rapid-acting insulin analogs are currently available: insulin aspart (Novolog), insulin glulisine (Apidra), and insulin lispro (Humalog). All three are approved for use in both type 1 and type 2 diabetes, either by subcutaneous (SC) injection, insulin pump, or intravenous infusion. PHARMACOKINETICS — An unpublished pharmacokinetic study (summarized in the package insert) conducted in 12 patients with type 1 diabetes compared 8 units of Afrezza with the same dose of insulin lispro. Serum concentrations peaked earlier with Afrezza, but the onset of action was similar with both drugs. The maximum effect occurred about 50 minutes after administration of Afrezza and about 120 minutes after injection of insulin lispro. Inhaled insulin had a shorter duration of action than insulin lispro (~3 vs. ~4 hours). CLINICAL STUDIES — Approval of Afrezza was based on 2 unpublished clinical studies which are summarized in the package insert. The first trial randomized 344 adults with uncontrolled t Continue reading >>

Aspart, Lispro, Glulisine Insulin (rapid Acting): Novolog, Humalog, Apidra (antidiabetics, Hormones)

Aspart, Lispro, Glulisine Insulin (rapid Acting): Novolog, Humalog, Apidra (antidiabetics, Hormones)

Generic Name aspart, lispro, glulisine Trade Name novolog, humalog, apidra Indication hyperglycemia with diabetes type 1 and 2, diabetic ketoacidosis Action stimulates uptake of glucose into muscle and fat cells, inhibits production of glucose in the liver, prevents breakdown of fat and protein Route Onset Peak Duration Aspart 10-20 min 1-3 hr 3-5 hr Glulisine 15 min 1 hr 2-4 hr Lispro 15 min 1-1.5 hr 3-4 hr Therapeutic Class antidiabetics, hormones Pharmacologic Class pancreatics Nursing Considerations assess for symptoms of hypoglycemia or hyperglycemia monitor body weight over time may cause decreased inorganic phosphates, potassium, and magnesium monitor blood sugars every 6 hours, monitor A1C every 3-6 months Date Modified - Jun 29, 2016 Continue reading >>

Humalog Vs Novolog

Humalog Vs Novolog

Humalog vs. Novolog Important Differences and More Afreeza versus Humalog. My son has been on the. Insulin helps to control blood sugar levels in diabetes mellitus, including diabetes type and diabetes type. Afreeza is the brand name of an inhaled insulin that has just been approved by the FDA. Acting type of insulin. What is the difference between the two. Afreeza is an inhaled insulin. Humalog since diagnosis and I really like it, because it works right now, and I. MannKind Releases Positive Results for Afrezza. Like Regular, Humalog and Novolog are used to cover meals and snacks. Most meals raise the blood sugar for only to hours afterwards. Find information about prescribing Humalog U. 90 minutes with Humalog. I have also heard that switching insulins is a big deal and to consult a doctor. Once injected, Regular. Humalog conversion to novolog Humalog conversion to novolog. Find information about prescribing Humalog U. I have read a lot about Novolog and it seems like that could. My health plan just changed, and I unfortunately have seen my price for. Humalog go up drastically. While using Humalog some say take carbs at the time of injection then eat your meal within one hour to one and a half hours. HumalogInsulin human, rDNA IUml 3 ml x 5 Eli Learn their similarities and differences. Humalog and Novolog are rapid. What humalog vs novolog is the difference between. Canada Pharmacy is an Canadian Pharmacy. Acting types of insulin. My son use Novolog insulin and my daughter uses Humalog insulin. Ml, solution for injection in Cartridge, Humalog KwikPen. When it comes to comparing insulin in the same family, say. Ml, solution for injection in vial. Novolog or Lantus vs. Levemir, should diabetics test drive different insulin products. Animas Ping insulin pump. I have two Continue reading >>

Comparison Of Insulin Aspart And Lispro: Pharmacokinetic And Metabolic Effects.

Comparison Of Insulin Aspart And Lispro: Pharmacokinetic And Metabolic Effects.

Abstract OBJECTIVE: To compare insulin levels and actions in patients with type 1 diabetes after subcutaneous injection of the rapid-acting insulin analogs aspart and lispro. RESEARCH DESIGN AND METHODS: Seven C-peptide-negative patients with type 1 diabetes (two men and five women) were studied at the General Clinical Research Center at Temple University Hospital two times, 1 month apart. Their plasma glucose was normalized overnight by intravenous infusion of insulin. The next morning, they received subcutaneous injections of either aspart or lispro (9.4 +/- 1.9 U) in random order. For the next 4-5 h, their plasma glucose was clamped at approximately 5.5 mmol/l with a variable infusion of 20% glucose. The study was terminated after 8 h. RESULTS: Both insulin analogs produced similar serum insulin levels (250-300 pmol/l) at approximately 30 min and disappeared from serum after approximately 4 h. Insulin aspart and lispro had similar effects on glucose and fat metabolism. Effects on carbohydrate metabolism (glucose uptake, glucose oxidation, and endogenous glucose production) peaked after approximately 2-3 h and disappeared after approximately 5-6 h. Effects on lipid metabolism (plasma free fatty acid, ketone body levels, and free fatty acid oxidation) appeared to peak earlier (at approximately 2 h) and disappeared earlier (after approximately 4 h) than the effects on carbohydrate metabolism. CONCLUSIONS: We conclude that both insulin aspart and lispro are indistinguishable from each other with respect to blood levels and that they are equally effective in correcting abnormalities in carbohydrate and fat metabolism in patients with type 1 diabetes. Continue reading >>

Humalog Vs Novolog Side Effects

Humalog Vs Novolog Side Effects

Humalog and Novolg which are similar drugs are fast acting insulins and are made by different pharmaceutical companies. In 2006 Eli Lilly introduced Humalog while in 2001 Novo Nordisk introduced Novolog. Those wanting to take either medication should take a look at possible side effects when it comes to taking medications for diabetes. Talk to your doctor regarding these medications before you make a decision to take them. If you decide to change from Humalog to Novolog, you might want to consider that a different dosage might be necessary. This is something that you and your doctor can decide together. A side effect when taking Humalog is often low blood sugar. Some of the symptoms include headache, nausea, hunger, confusion, drowsiness, weakness, dizziness, blurred vision, fast heartbeat, sweating, tremors, trouble concentrating, confusion and severe cases, seizure. Make sure you carry some glucose tablets or dietetic hard candy to ward off low blood sugar. Itching, swelling, redness or thickening of the skin on the injection site can be some of the more severe symptoms. If you have any of these symptoms, call your doctor. As for Novolog, side effects may include back pain, diarrhea, indigestion, itching, mild pain on the injection site, runny nose and weight gain. Again if you have a severe allergic reaction you should call your doctor if you end up with a rash, hives, difficulty breathing, tightness in the chest, swelling of the mouth, face, lips or tongue. Also if you have tingling in the arms, hands, legs or feet. Some people will experience symptoms differently than others. Age, weight, body type and even ethnicity and even your sex can play a part in the reactions you might get. Women can react quite differently than a man to a drug. It is important to note that Continue reading >>

When You Can't Afford The Insulin That You Need To Survive | How To Use The Cheap

When You Can't Afford The Insulin That You Need To Survive | How To Use The Cheap "old-school" Insulin

Note: BootCamp for Betics is not a medical center. Anything you read on this site should not be considered medical advice, and is for educational purposes only. Always consult with a physician or a diabetes nurse educator before starting or changing insulin doses. Did you know that all type 1 diabetics and some type 2 diabetics need injectable insulin in order to live? Put another way, if a diabetic needs insulin in order to live, and the diabetic does not get insulin, the diabetic will die. Diabetic death from Diabetic Ketoacidosis is a grisly process, during which acid starts running through your bloodstream, searing your vessels and organs while your body shrivels up in dehydration as it tries to push the acid out of your body through your urine and lungs, and, left untreated, the condition shuts down your organs one by one until you are dead. If you're lucky, your brain will be the first thing to swell itself into a coma and you'll be unconscious for the remainder of the organ failures. In some cases, this grisly diabetic death can take a few days or weeks to complete its process. Or, if you're one of the luckier less-resistant insulin-dependent type 2 diabetics, you may actually get away with staying alive for quite a few years and suffer only some heart disease, stroke, kidney damage/failure, neuropathy, limb amputations and blindness. (my intent in describing how lack of insulin leads to death is not to cause fear in people with diabetes or their loved ones; rather, my intent is to make clear the reality that injectable insulin is absolutely vital to diabetics who depend on injectable insulin to live) While I'd love to go off on a political rant about how insulin should be a basic human right for all insulin-dependent diabetics (and why the hell isn't it?), that' Continue reading >>

The Switch: How I Accidentally Found The Right Insulin

The Switch: How I Accidentally Found The Right Insulin

WRITTEN BY: Chris Wiggins Note: This article is a part of our library of resources in Tools & How to. Check out more helpful product reviews and run downs on different diabetes management devices here. One of the unfortunate realities of being a Type 1 diabetic in the American healthcare system is that we don’t always have control of the medications we receive. I’ve changed insulin back and forth from Novolog to Humalog over my time with the pump due merely to the preference of my insurance company at the time. While those two insulins were nearly identical based on my blood sugar levels, I recently was put on a new insulin for the reason that it is the only insulin my new insurance covered. That insulin is Apidra, an insulin I had never even heard mentioned by my doctors despite it being on the market since 2004. At first I didn’t know much about the new insulin, except that it was similar to Humalog, the insulin I had previously been prescribed. I was told it was slightly faster acting, but my dosages for carbohydrates and lowering my blood sugar shouldn’t change by much. While fairly skeptical about the new insulin I chose my first few meals carefully (low carbs, high fiber) and monitored my blood sugar closely. Everything seemed fine and similar to Humalog, so I figured it was just the same medicine with a new name/logo. Then after a few days I tested the insulin against a high carbohydrate sandwich from one of my favorite sandwich places. These sandwiches are not what I would call “diabetic friendly” as the bread rolls are massive, clocking in an estimated 100-120 grams of carbohydrates for my preferred roll, Dutch Crunch. What happened next was surprising. In my experience eating anything over 100 grams of carbohydrates in a single meal, I would always Continue reading >>

Humalog U-200 Kwikpen Could Cost Patients Less Than Humalog U-100 Kwikpen

Humalog U-200 Kwikpen Could Cost Patients Less Than Humalog U-100 Kwikpen

Humalog U-200 KwikPen may be an effective option—from mealtime initiation through dosage increases—so fewer changes in therapy may be needed down the road* Patient preference (vs Humalog U-100 KwikPen) 9 out of 10 patients expressing a preference preferred Humalog U-200 KwikPen over Humalog U-100 KwikPen†1 In a single-visit, 2-period, crossover, simulated-use preference study, 101 patients compared U-100 KwikPen and U-200 KwikPen by injecting 15 units and 50 units into an injection pad to determine final preference (95% CI, 0.81-0.94; P<.0001). Afterwards, they completed 2 self-administered questionnaires (Insulin Device Assessment Battery and Insulin Device Preference Battery adapted for this study) to determine final preference.1 Bioequivalence—with half the volume Bioequivalent‡ to Humalog U-100 so you can expect a similar efficacy and safety profile. Plus, it delivers the same dose in half the liquid volume. Savings Available at the lowest brand co-pay for most patients,§ and could even cost less than Humalog U-100 KwikPen|| Option for patients who require >20 units of mealtime insulin/day. In a device preference study between U-200 KwikPen and U-100 KwikPen, 90/101 patients expressed a preference between the devices. As determined by area under the curve and maximum concentration. Source: Managed Markets Insight & Technology (MMIT), LLC as of 06/2017, and is subject to change without notice by a health plan or state. Please contact the plan or state for the most current information. “Patients” consists of all insured lives (Medicaid, Medicare, commercial insurance). See full terms and conditions on back of savings card. For eligible commercially insured patients. Continue reading >>

What Is Novolog (insulin Aspart)?

What Is Novolog (insulin Aspart)?

Before you receive DARZALEX®, tell your healthcare provider about all of your medical conditions, including if you: have a history of breathing problems have had shingles (herpes zoster) are pregnant or plan to become pregnant. DARZALEX® may harm your unborn baby. Females who are able to become pregnant should use an effective method of birth control during treatment and for at least 3 months after your final dose of DARZALEX®. Talk to your healthcare provider about birth control methods that you can use during this time. are breastfeeding or plan to breastfeed. It is not known if DARZALEX® passes into your breast milk. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. DARZALEX® may be given alone or together with other medicines used to treat multiple myeloma. Your healthcare provider will decide the time between doses as well as how many treatments you will receive. Your healthcare provider will give you medicines before each dose of DARZALEX® and on the first day after each dose of DARZALEX® to help reduce the risk of infusion reactions. If you miss any appointments, call your healthcare provider as soon as possible to reschedule your appointment. Infusion reactions. Infusion reactions are common with DARZALEX® and can be severe. Your healthcare provider may temporarily stop your infusion or completely stop treatment with DARZALEX® if you have infusion reactions. Tell your healthcare provider right away if you get any of the following symptoms: shortness of breath or trouble breathing dizziness or lightheadedness (hypotension) cough wheezing throat tightness runny or stuffy nose headache itching nausea vomiting chills fever Changes in blood tests. DARZALEX Continue reading >>

Insulin Aspart

Insulin Aspart

Insulin aspart is a fast-acting insulin analog marketed by Novo Nordisk as NovoLog/NovoRapid. It is a manufactured form of human insulin; where a single amino acid has been exchanged. This change helps the fast-acting insulin analog be absorbed quickly into the bloodstream. As a result, it starts working in minutes, which allows one to take insulin and eat right away. Fast-acting insulin analogs are considered to act similarly to the way insulin is released in people without diabetes mellitus. Novolog allows for a flexible dosing schedule, which allows patients to adjust their insulin according to any changes in their eating habits.[1] The safety and efficacy of insulin aspart (NovoLog/NovoRapid) in real-life clinical practice was evaluated in the A1chieve study. It was created through recombinant DNA technology so that the amino acid, B28, which is normally proline, is substituted with an aspartic acid residue. This analog has increased charge repulsion, which prevents the formation of hexamers, to create a faster-acting insulin. The sequence was inserted into the yeast genome, and the yeast expressed the insulin analog, which was then harvested from a bioreactor. According to JDRF, insulin aspart was approved for marketing in the United States by the Food and Drug Administration in June 2000.[citation needed] Chemical properties[edit] The components of insulin aspart are as follows: Metal ion – zinc (19.6 μg/mL) Buffer – disodium hydrogen phosphate dihydrate (1.25 mg/mL) Preservatives – m-cresol (1.72 mg/mL) and phenol (1.50 mg/mL) Isotonicity agents – glycerin (16 mg/mL) and sodium chloride (0.58 mg/mL). The pH of insulin aspart is 7.2–7.6.[2] Action time[edit] The onset of action is approximately 15 minutes, the peak action is reached in 45–90 minutes, Continue reading >>

Humalog Vs Novolog (novalog): What's The Difference?

Humalog Vs Novolog (novalog): What's The Difference?

Humalog and Novolog are both rapid acting forms of insulin that work for short periods of time. Humalog Vs Novolog: Both human insulin analogs Humalog is a brand name for insulin lispro. Humalog starts to work about 15 minutes after injection, peaks in about 1 hour, and keeps working for 2 to 4 hours. Novolog is a brand name for insulin aspart. NovoLog starts to work about 15 minutes after injection, peaks in about 1 hour, and keeps working for 2 to 4 hours. Novolog is commonly misspelled as Novalog. Both medicines may be prescribed along with long-acting or intermediate-acting insulins. Humalog Vs Novolog: What exactly is the difference? Insulin consists of two polypeptide chains (A and B) linked together by disulfide bonds. Insulin lispro is human insulin that has been modified so that the amino acid proline has been substituted for lysine in position 28 of the B-chain, and lysine has been substituted for proline at position 29 of the B-chain. Insulin Aspart is human insulin that has a single substitution of proline for aspartic acid in position 28 of the B-chain. These seemingly minor substitutions significantly increase the rate of absorption of these insulin analogs into blood after subcutaneous injection. Peak concentrations are reached quicker than with regular human insulin, postprandial glucose control (level of blood sugars after a meal) is also improved, and there is less risk of late hypoglycemia (low blood sugar). Humalog Vs Novolog: Are there any differences in effect in people with diabetes? One small study concluded that there were no differences between Insulin lispro (Humalog) and Insulin Aspart (Novolog) in people with type 1 diabetes. Insulin levels in blood were similar 30 minutes after subcutaneous injection of either Lispro or Aspart and both disa Continue reading >>

Humalog Vs Novolog

Humalog Vs Novolog

Distinctive insulin shots are arranged alongside one another by how it functions concerning the duration, crest, and how quick the starting point is. Length of time will tell to what extent the insulin will have the capacity to bring down the glucose, optimum will tell the time, when the insulin is powerful, and oncoming will depict the time-frame before the insulin will start bringing down the glucose. Quick-acting as well as swift reacting, slow reacting, and premixes are the fundamental diverse insulin shots; Humalog & Novolog is one of them. Precisely how rapid insulin starts to work on the body and to what extent it continues relying on the product, so it’s imperative for anybody utilizing insulin to peruse with the information related to the particular brand when changing to another solution or distinctive insulin brands. Quick-acting insulins, in the same way as Humalog vs Novolog, will start between ten to thirty minutes, crest in about a half hour to ninety minutes, which can also last up to five hours. Humalog and Novolog are simple insulins used to cover up the glucose from the diet. They both are fast reacting insulins to cover up diet, however, Humalog is a bit faster than Novolog; maybe about 10 minutes faster. Although, they are identical to each other and they just different in a few scenarios. Their brands are different, but they both are excellent quality type 1 diabetes drug. Numerous individuals utilize more than one kind of insulin to manage their sugar levels. Quite a few types of insulin ought not be combined in the same compound, so check with your specialist or pharmacologist before doing any mixing procedures. Some individuals use light and strong reacting insulin. However Humalog and Novolog are both fast reacting insulins. So both should no Continue reading >>

The Rising Price Of Insulin

The Rising Price Of Insulin

Diabetes is a chronic disease that afflicts 25.8 million Americans. Insulin, one of the primary treatments for diabetes, has been around since the 1920s. Yet, somehow the drug is still priced beyond the reach of many Americans. One of our advocates recently left a comment on our Facebook page regarding this problem, which encouraged us to take a closer look at it. Medication nonadherence (patients not taking medicine as prescribed) is undeniably related to diabetes-related health complications that result in emergency room visits and lost productivity. Diabetes is an expensive and deadly disease. It is the seventh leading cause of death in the U.S. and cost the country $245 billion last year. A few big pharmaceutical firms dominate the insulin market due to lengthy patents and lack of generic competition. Insulin is a biologic drug, which means that it is made up of living organisms rather than chemical compounds. This makes it more difficult to copy, which biotech companies often use as justification for the exorbitant prices they charge for the drugs. We’ve had anecdotal evidence from a consumer of a big price hike on her Humalog insulin this year. When she was trying to find out further information about the price increase, she was told by her insurance company to expect the drug to go up 25 percent more in December. News reports indicate that the cost of Lantus, a top-selling insulin produced by Sanofi, has gone up twice already this year, first 10 and then 15 percent. In addition, Novo Nordisk has also increased the price of Levemir, another common insulin treatment, by 10 percent. What’s going on here? Overall drug spending is slightly down due to generic drug utilization being up. And generic competition isn’t too far off for many of these drugs. It looks l Continue reading >>

Fiasp Insulin, Insulin Aspart, Fiasp Vs Novolog

Fiasp Insulin, Insulin Aspart, Fiasp Vs Novolog

It’s understandable if you are wondering what Fiasp insulin is. The truth is, we were wondering the same thing when the FDA announced its approval of Novo Nordisk’s new, first in class, injectable, “faster-acting” insulin. What do we mean by faster-acting insulin? Well, now there are two levels of fast when it comes to mealtime (rapid-acting) insulin: Fast and Faster. Insulin aspart is a powerhouse in the world of diabetes. It was introduced under the brand name Novolog in June of 2000. For over 15 years, Novolog has been a staple of insulin regimens for many patients. Novolog and Humalog are the two most commonly prescribed fast-acting insulins that patients take within 15 minutes of mealtime. For this article, we will be paying closer attention to insulin aspart (more commonly called Novolog or Novorapid® in Europe and Canada). Novolog itself is an insulin analogue. This means it has been modified from regular insulin to change its structure and how quickly it is absorbed from under the skin. Novo Nordisk teamed up their workhorse Novolog insulin with a B3 vitamin (nicotinamide) to make it absorb more quickly and the amino acid arginine to stabilize it. That’s right! Fiasp insulin is simply Novolog with two small additions: Vitamin B3 and naturally occurring arginine. Researchers discovered that adding nicotinamide to the insulin aspart molecule causes its initial absorption to happen more quickly. This means it acts more like the insulin normally made by your pancreas. Fiasp insulin can even be taken up to 20 minutes AFTER starting the meal! So if Fiasp were racing Novolog, it could give Novolog a 15-minute head start and still catch up! Not only that, but twice as much insulin is available within 30 minutes of injecting Fiasp as compared to Novolog. More Continue reading >>

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