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Humalog Not Working

Experiences With Humalog

Experiences With Humalog

Just wanted to know if anyone else out there experiences this with their humalog I switched from R & NPH to Lantus and Humalog about 18 months ago. What I am finding is I seem to have a pattern of humalog working great for 2-3 weeks and then it will stop working properly for 2-3 weeks. Example, when humalog is working as I expect it should I will take 6 units for a meal where I am eating 60 carbs. When humalog is not working properly those 6 units will have no effect on 60 carbs and my blood sugar will rise to the point where I have to inject another 6 units before i will see it start to take effect. My A1C was 5.9 six months ago and my most recent (last week) was 6.7. I'm attributing this rise in my A1C to the ineffectiveness of humalog as my diet and exercise routine has not changed. I just want to hear from others if they have experienced similar issues with humalog and what, if anything, they have done to deal with it. I am meeting my endrocrinologist this week to discuss, but am not hopeful as I never get straight answers on these issues. To be told by your physician "I dont know" is upsetting. I've been on Humalog since May, when I had to switch from Novolog due to insurance coverage. I've never noticed anything like you describe. Humalog has been very consistent for me, though it is a little weaker in its ability to lower BG than Novolog. I have to use an I:C ratio of 1:4 for breakfast and 1:7 the rest of the day with Humalog, whereas with Novolog my ratios were 1:5 and 1:8. Others have said they had exactly the opposite, that Humalog seemed a little stronger for them. I've never seen anyone mention a pattern forming over the month, so I'll be interested to see what replies you get here. If you were a young woman, I'd suspect the variation was due with your mont Continue reading >>

Humalog Vs. Novolog: Important Differences And More

Humalog Vs. Novolog: Important Differences And More

Humalog and Novolog are two diabetes medications. Humalog is the brand-name version of insulin lispro, and Novolog is the brand-name version of insulin aspart. These drugs both help control blood glucose (sugar) in people with type 1 and type 2 diabetes. Humalog and Novolog are both rapid acting. That means they work more quickly than other types of insulin. There are important distinctions between Humalog and Novolog, however, and the drugs are not directly interchangeable. Check out this comparison so you can work with your doctor to choose a drug that’s right for you. Insulin is injected under your skin fat. It’s the most common type of treatment for type 1 diabetes because it works quickly. It’s also the only type of diabetes medication that’s absorbed into the bloodstream. Humalog and Novolog are both equivalent to the insulin made in your body. Unlike oral diabetes drugs, insulin provides fast relief for changes in your blood sugar. The type of insulin your doctor prescribes depends on how often and how much your blood sugar fluctuates each day. The table below provides quick facts at a glance. Brand name Humalog Novolog What is the generic drug? insulin lispro insulin aspart Is a generic version available? no no What does it treat? type 1 and type 2 diabetes type 1 and type 2 diabetes What form does it come in? solution for injection solution for injection What strengths does it come in? • 3-mL cartridges • 3-mL prefilled KwikPen • 3-mL vials • 10-mL vials • 3-mL FlexPen • 3-mL FlexTouch • 3-mL PenFill cartridges • 10-mL vials What is the typical length of treatment? long-term long-term How do I store it? Refrigerate at 36° to 46°F (2° to 8°C). Do not freeze the drug. Refrigerate at 36° to 46°F (2° to 8°C). Do not freeze the drug. Continue reading >>

About Fast-acting Mealtime Insulin

About Fast-acting Mealtime Insulin

What is mealtime insulin? Mealtime insulins are fast-acting insulins that are taken immediately before or after meals. As you eat, your blood sugar naturally goes up, or “spikes.” Humalog® (a fast-acting insulin) works to manage those blood sugar spikes and may help keep your sugar levels in balance. Humalog should be taken within 15 minutes before eating or right after eating a meal. People who take Humalog will usually continue to take longer-acting insulin to help manage blood sugar levels at night and between meals. Taking mealtime insulin in addition to longer-acting insulin may help to control blood sugar levels throughout the day. Low blood sugar (hypoglycemia) is the most common side effect of Humalog that may be severe and cause unconsciousness (passing out), seizures, and death. Test your blood sugar levels as your doctor instructs. Talk to your doctor about low blood sugar symptoms and treatment. The orange area shows how blood sugar levels typically rise after meals. The pattern of insulin action may vary in different individuals or within the same individual. Comparing types of insulin Take a look at our overview below to find out about the different types of insulin. You’ll notice that there are differences in when the types of insulin reach your bloodstream, when they “peak” in your body, and how long they can last (length of time the insulin keeps lowering your blood sugar). Fast-acting insulin (also called rapid-acting) is absorbed quickly and starts working in about 15 minutes to lower blood sugar after meals. Humalog fast-acting insulin should be taken 15 minutes before eating or right after eating a meal. Depending on the type of diabetes you have, you may need to take Humalog with a longer-acting insulin or oral anti-diabetes medication. Continue reading >>

Humalog Vs. Novolog: What’s The Difference?

Humalog Vs. Novolog: What’s The Difference?

The two leaders in the fast acting insulin market, Humalog and Novolog, are the most common types of fast acting insulin used by those with diabetes today. Fast Acting, mealtime insulin is a type of insulin that is injected before or right after eating. When you eat your blood glucose begins to rise. Fast acting insulin, Humalog and Novolog work to help manage these rises or spikes to keep your blood glucose levels more within range and balanced. When you use a fast acting insulin like Humalog or Novolog, you typically will continue to take a long acting insulin to help manage your levels between your meals and throughout the night. The question is though, is there really a difference between the two? Endocrinologists and other medical professionals don’t seem to really think there is, stating the two are virtually interchangeable. But that’s not really the full story. Humalog (Insulin Lispro) Insulin Lispro (Humalog) has been on the market since 1996, when it was first introduced by Eli Lily. Humalog is the first insulin analogue that was used clinically. Insulin Lispro received its name due to its structure. The difference between it and regular insulin was the switch between the lysine B28 (an amino acid) and proline B29. The formula consists of a hexametric solution available in vials and pen form. After a subcutaneous injection, the formula converts into a monomeric formula which allows it to have a fast absorption in the body. The one noted negative factor of Humalog is its short term control of glucose levels. Additionally, if it is injected and mealtime happens to be delayed, a hypoglycemic episode may occur. For Humalog to be most effective it is to be injected 15 minutes prior to the start of a meal. I recommend reading the following articles: Humalog is a Continue reading >>

Where To Inject Humalog Mix 75/25 And Mix 50/50

Where To Inject Humalog Mix 75/25 And Mix 50/50

Humalog (insulin lispro injection) is used to treat people with diabetes for the control of blood sugar. Humalog is used to treat people with diabetes for the control of blood sugar. Humalog Mix75/25(75% insulin lispro protamine suspension and 25% insulin lispro injection) and Humalog Mix50/50(50% insulin lispro protamine suspension and 50% insulin lispro injection) are used to treat adults with diabetes for the control of high blood sugar. Do not take Humalog if your blood sugar is too low (hypoglycemia) or if you are allergic to insulin lispro or any of the ingredients in Humalog. Important Safety Information for Humalog Brand of Insulins What is the most important information I should know about Humalog, Humalog Junior KwikPen, Humalog 200 units/mL KwikPen, Humalog Mix75/25, and Humalog Mix50/50? Do not share your Humalog, Humalog Junior, Humalog Mix75/25, or Humalog Mix50/50 KwikPens, cartridges, reusable pen compatible with Lilly 3 mL cartridges, or syringes with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them. Humalog 200 units/mL KwikPen contains 2 times as much insulin (200 units/mL) in 1 mL as standard insulin (100 units/mL). The Humalog contained in the Humalog U-200 KwikPen should ONLY be injected with the Humalog U-200 KwikPen. Do NOT withdraw Humalog U-200 from the pen using a syringe. It could result in an overdose causing severe low blood sugar which may put your life in danger. Do not change the insulin you use without talking to your healthcare provider. Changes may make you more likely to experience low or high blood sugar. Changes should be made cautiously under the supervision of your healthcare provider. Test your blood sugar levels as your healthcare provider ins Continue reading >>

What Are The Possible Side Effects Of Insulin Lispro (humalog, Humalog Cartridge, Humalog Kwikpen, Humalog Pen)?

What Are The Possible Side Effects Of Insulin Lispro (humalog, Humalog Cartridge, Humalog Kwikpen, Humalog Pen)?

HUMALOG (insulin lispro) Injection DESCRIPTION HUMALOG® (insulin lispro injection) is a rapid-acting human insulin analog used to lower blood glucose. Insulin lispro is produced by recombinant DNA technology utilizing a non-pathogenic laboratory strain of Escherichia coli. Insulin lispro differs from human insulin in that the amino acid proline at position B28 is replaced by lysine and the lysine in position B29 is replaced by proline. Chemically, it is Lys(B28), Pro(B29) human insulin analog and has the empirical formula C257H383N65O77S6 and a molecular weight of 5808, both identical to that of human insulin. HUMALOG has the following primary structure: HUMALOG is a sterile, aqueous, clear, and colorless solution. Each milliliter of HUMALOG U-100 contains insulin lispro 100 units, 16 mg glycerin, 1.88 mg dibasic sodium phosphate, 3.15 mg Metacresol, zinc oxide content adjusted to provide 0.0197 mg zinc ion, trace amounts of phenol, and Water for Injection. Insulin lispro has a pH of 7.0 to 7.8. The pH is adjusted by addition of aqueous solutions of hydrochloric acid 10% and/or sodium hydroxide 10%. Each milliliter of HUMALOG U-200 contains insulin lispro 200 units, 16 mg glycerin, 5 mg tromethamine, 3.15 mg Metacresol, zinc oxide content adjusted to provide 0.046 mg zinc ion, trace amounts of phenol, and Water for Injection. Insulin lispro has a pH of 7.0 to 7.8. The pH is adjusted by addition of aqueous solutions of hydrochloric acid 10% and/or sodium hydroxide 10%. font size A A A 1 2 3 4 5 Next What is Type 2 Diabetes? The most common form of diabetes is type 2 diabetes, formerly called non-insulin dependent diabetes mellitus or "adult onset" diabetes, so-called because it typically develops in adults over age 35, though it can develop at any age. Type 2 diabetes i Continue reading >>

Helpful Hints For Humalog:

Helpful Hints For Humalog:

WHAT YOU NEED TO KNOW by John Walsh, P.A., C.D.E., and Ruth Roberts, M.A. Copyright--1996 by Diabetes Services, Inc. The new, fast insulin Humalog, is finally here. Since the introduction of Lilly's new insulin, many people have been switching over. This is the first insulin produced since 1921 that can really cover most meals, and its speed of action offers users more flexibility and control. This article provides helpful hints for safety and success when starting this new product. Almost everyone who is switching to Humalog is doing so to replace their Regular insulin. Regular is often thought of as "meal" Regular or "high blood sugar" Regular, but its action time of five to eight hours more closely resembles a long-acting insulin. After switching from Regular to Humalog, many people have found that fewer units of Humalog are needed to cover the same food. Fewer units may also be needed to lower high blood sugars. Others have discovered that as meal doses are lowered, they need to raise their long-acting insulin to replace some of the lost meal dose. The Regular insulin most people take for breakfast has, in effect, been lowering their after-lunch blood sugars as well. This prolonged action is no longer seen with Humalog. Several of my (John's) patients and several diabetes colleagues have found they need extra long-acting insulin in the morning after switching in order to keep the afternoon and pre-dinner readings down. Another alternative is to use extra Humalog to cover lunch. When given before most meals, Humalog will cover these meals only during the time they are raising the blood sugar. Its action is gone before the next meal begins, and most importantly for many, before going to bed. This eliminates many nighttime lows. But with the loss of the longer action o Continue reading >>

How To Use Humalog Kwikpen

How To Use Humalog Kwikpen

Humalog (insulin lispro injection) is used to treat people with diabetes for the control of blood sugar. Humalog is used to treat people with diabetes for the control of blood sugar. Humalog Mix75/25(75% insulin lispro protamine suspension and 25% insulin lispro injection) and Humalog Mix50/50(50% insulin lispro protamine suspension and 50% insulin lispro injection) are used to treat adults with diabetes for the control of high blood sugar. Do not take Humalog if your blood sugar is too low (hypoglycemia) or if you are allergic to insulin lispro or any of the ingredients in Humalog. Important Safety Information for Humalog Brand of Insulins What is the most important information I should know about Humalog, Humalog Junior KwikPen, Humalog 200 units/mL KwikPen, Humalog Mix75/25, and Humalog Mix50/50? Do not share your Humalog, Humalog Junior, Humalog Mix75/25, or Humalog Mix50/50 KwikPens, cartridges, reusable pen compatible with Lilly 3 mL cartridges, or syringes with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them. Humalog 200 units/mL KwikPen contains 2 times as much insulin (200 units/mL) in 1 mL as standard insulin (100 units/mL). The Humalog contained in the Humalog U-200 KwikPen should ONLY be injected with the Humalog U-200 KwikPen. Do NOT withdraw Humalog U-200 from the pen using a syringe. It could result in an overdose causing severe low blood sugar which may put your life in danger. Do not change the insulin you use without talking to your healthcare provider. Changes may make you more likely to experience low or high blood sugar. Changes should be made cautiously under the supervision of your healthcare provider. Test your blood sugar levels as your healthcare provider ins Continue reading >>

Can Your Body Reject Insulin If Badly Controlled?

Can Your Body Reject Insulin If Badly Controlled?

Save for later Q. Can your body reject insulin if badly controlled? A. You seem concerned that your body may be rejecting insulin that is injected which is leading to trouble controlling your blood glucose levels. If so is there a particular reason you think this may be happening? Your body does not reject injected insulin, however, if you are finding doses you are used to are not working as well or you are needing much higher doses, there could be a number of reasons for this. The first thing to check is the insulin itself. Is the insulin within the expiry date? Has it been exposed to extreme hot/cold temperatures or has it been in use for over 28 days? Any of these things could mean the insulin is damaged. If you think it may be, or you are not sure, then it might be sensible to start a new vial just to be on the safe side. Another thing to check is your injection sites/insertion sites. Are there any raised lumps, dimples or hardened areas? Any problems of this kind may interrupt the absorption rate of insulin. If you are unsure whether your injection sites are as they should be, then you may want to ask your diabetes nurse to have a look at them for you. Another thing that can happen, particularly during adolescence when hormones can be unpredictable, is that insulin resistance can develop. Insulin resistance means that any insulin you have injected cannot be used properly and so is not effective enough at lowering blood glucose levels. There can be few ways of tackling this. Insulin resistance can develop in people who are very overweight, I am not sure if this is the case for you, but losing extra weight, if applicable, should reduce insulin resistance. As mentioned before however, insulin resistance is more likely to occur during the teenage years and be completel Continue reading >>

Important Safety Information For Humalog Brand Of Insulins

Important Safety Information For Humalog Brand Of Insulins

Indication for Humalog Brand of Insulins Humalog® is used to treat people with diabetes for the control of blood sugar. Humalog® Mix75/25™(75% insulin lispro protamine suspension and 25% insulin lispro injection) and Humalog® Mix50/50™(50% insulin lispro protamine suspension and 50% insulin lispro injection) are used to treat adults with diabetes for the control of high blood sugar. Do not take Humalog if your blood sugar is too low (hypoglycemia) or if you are allergic to insulin lispro or any of the ingredients in Humalog. What is the most important information I should know about Humalog, Humalog Junior KwikPen, Humalog 200 units/mL KwikPen, Humalog Mix75/25, and Humalog Mix50/50? Do not share your Humalog, Humalog Junior, Humalog Mix75/25, or Humalog Mix50/50 KwikPens, cartridges, reusable pen compatible with Lilly 3 mL cartridges, or syringes with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them. Humalog 200 units/mL KwikPen contains 2 times as much insulin (200 units/mL) in 1 mL as standard insulin (100 units/mL). The Humalog contained in the Humalog U-200 KwikPen should ONLY be injected with the Humalog U-200 KwikPen. Do NOT withdraw Humalog U-200 from the pen using a syringe. It could result in an overdose causing severe low blood sugar which may put your life in danger. Do not change the insulin you use without talking to your healthcare provider. Changes may make you more likely to experience low or high blood sugar. Changes should be made cautiously under the supervision of your healthcare provider. Test your blood sugar levels as your healthcare provider instructs. Your insulin dose may need to change because of illness, stress, other medicines you take, change in die Continue reading >>

Insulin Not Lowering Bs

Insulin Not Lowering Bs

Diabetes Forum The Global Diabetes Community This site uses cookies. By continuing to use this site, you are agreeing to our use of cookies. Learn More. Get the Diabetes Forum App for your phone - available on iOS and Android . Find support, ask questions and share your experiences. Join the community I'm struggling to lower my BS. I've eaten literally no carbs this morning as I'm on a LCHF diet. One hour later I was 7.9 (even though I consumed nothing) After a little cheese and a bulletproof coffee at 10 am my BS was 14.5 Something other than carbs (because I've had very little carbs) is causing my BS to rise really high, and it's like my insulin is not working. Hello @Lord Midas The only times I get this is when either my insulin isn't effective so change your cartridge, or i'm coming down with an infection (dental or possibly cold/illness) and finally down to injection sites so check for lumps. First port of call is to change your insulin cartridge and see if it's this then look at other possibilities, you should be able to work out why eventually though Hello @Lord Midas The only times I get this is when either my insulin isn't effective so change your cartridge, or i'm coming down with an infection (dental or possibly cold/illness) and finally down to injection sites so check for lumps. First port of call is to change your insulin cartridge and see if it's this then look at other possibilities, you should be able to work out why eventually though Fortunately, I don't have a cold or illness and I've not changed my cartridge since last week. A fresh one sounds like a good idea though. However... I have changed my site. I was almost exclusively using the right side of my belly, and now I've moved the the left. The Right is getting a little hard. But this hasn't made Continue reading >>

Novolog Vs Humalog: Which Is Better?

Novolog Vs Humalog: Which Is Better?

Ahhh yes, the million dollar question. In the land of type 1 diabetes and rapid acting insulin, everyone wants to know, which works better…Novolog vs Humalog? Thank You Insurance Companies (not!) You’re probably here because your insurance company has pulled the plug on your beloved insulin and is making you switch to the dark side. Whether they signed a deal with Lilly (Humalog) or Novo Nordisk (Novolog) you’re left in sheer panic because WTH insurance companies?! This is my life juice you’re messing with here. You’ve been reassured by your doctor…and their nurses…and the pharmacist that there is no difference between the two brands… It’s like pepsi vs coke – my doctors nurse. Well, if you know anything about pepsi or coke then you know… while it’s true that some can’t taste the difference, others most definitely can. Same is true with Novolog vs Humalog. Show me the differences! Novolog vs Humalog But first, the similarities. Both Novolog and Humalog are human insulin analogs. This means that they are a synthetically altered form of human insulin – the kind that you find naturally occurring in the human body (as opposed to being extracted from cows and pigs – like it was back in the 20’s). Both should begin working in about 15 minutes after injection, should peak in about 1 hour, and should continue to work for 2-4 hours. What’s with all the shoulds? Everyone reacts to medications differently; insulin is no exception. …which brings me to the differences In Humalog (insulin lispro) the amino acids for proline and lysine have been swapped. This means that the amino acid, proline, has been substituted for lysine in position 28 of the B-Chain, and lysine has be substituted for proline in position 29 of the B-Chain. In Novolog (insulin a Continue reading >>

Contact Lilly | Humalog

Contact Lilly | Humalog

Humalog (insulin lispro injection) is used to treat people with diabetes for the control of blood sugar. Humalog is used to treat people with diabetes for the control of blood sugar. Humalog Mix75/25(75% insulin lispro protamine suspension and 25% insulin lispro injection) and Humalog Mix50/50(50% insulin lispro protamine suspension and 50% insulin lispro injection) are used to treat adults with diabetes for the control of high blood sugar. Do not take Humalog if your blood sugar is too low (hypoglycemia) or if you are allergic to insulin lispro or any of the ingredients in Humalog. Important Safety Information for Humalog Brand of Insulins What is the most important information I should know about Humalog, Humalog Junior KwikPen, Humalog 200 units/mL KwikPen, Humalog Mix75/25, and Humalog Mix50/50? Do not share your Humalog, Humalog Junior, Humalog Mix75/25, or Humalog Mix50/50 KwikPens, cartridges, reusable pen compatible with Lilly 3 mL cartridges, or syringes with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them. Humalog 200 units/mL KwikPen contains 2 times as much insulin (200 units/mL) in 1 mL as standard insulin (100 units/mL). The Humalog contained in the Humalog U-200 KwikPen should ONLY be injected with the Humalog U-200 KwikPen. Do NOT withdraw Humalog U-200 from the pen using a syringe. It could result in an overdose causing severe low blood sugar which may put your life in danger. Do not change the insulin you use without talking to your healthcare provider. Changes may make you more likely to experience low or high blood sugar. Changes should be made cautiously under the supervision of your healthcare provider. Test your blood sugar levels as your healthcare provider ins Continue reading >>

Humalog Problems? - Type 1 Diabetes - Diabetes Forums

Humalog Problems? - Type 1 Diabetes - Diabetes Forums

Registration is fast, simple and absolutely free so please,join our community todayto contribute and support the site. This topic is now archived and is closed to further replies. For some reason I do not think humalog is working for me. My fasting number is around 100-120. I will take my humalog before I eat, which is usually 10 to 20 carbs a meal. An hour after eating I will be at 180. Two hours I will spike to over 200. But at the 3 and 4 hour mark I will drop, and I drop fast and usually end up hypo. This happened the other night, I had some tuna on a salad. I spiked to about 200, and 3 1/2 hours later I was passed out with my meter reading low. I tried lowering my dose, but that isnt helping either. I think the amount I take is right, just not kicking in fast enough? As far as I know humalog is supposed to work within 30 minutes? Can someone explain this to me? I am trying very hard to get a handle of this, but with the constant hypos its driving me crazy! The general profile of the fast acting analogs like Novolog, Humalog and Apidra is that they start working in 15 minutes, peak rate of absorption about 1 to 1.5 hours after injection and are fully used after about 4 to 5 hours. A useful profile to remember is this general scheme -- After 1.5 hours, 50% of the bolus will be used up. But those are only general rules of thumb. With you it almost sounds like it's taking some time for the injection to begin working. If you're consistently seeing late drops like that, you might want to talk to your doctor and ask about trying Novolog or Apidra -- some people report that they get better, faster, more consistent absorption from other brands of rapid acting insulins than others. This is one of the most difficult problems to tackle. Humalog is not gone in 4 hours. It will Continue reading >>

Managing Blood Sugar

Managing Blood Sugar

Everyone’s experience with mealtime insulin is different, but there are some things you can look out for. Your Humalog dose will probably change over time. Your doctor gave you a starting dose, but most people need to increase their Humalog dose over time. When you track your blood sugar every day, you will probably see different numbers all the time. These variations in your blood sugar from day to day are normal. Your blood sugar varies based on stress, what you eat, other medications, exercise, and other factors. Don't be discouraged by changes in your blood sugar. With your doctor’s input, these variations may provide learning opportunities. Testing your blood sugar When using mealtime insulin like Humalog, you must test your blood sugar (glucose) regularly. For example, you may need to test before and after meals and at bedtime. Your doctor will tell you when and how often you should test. Why keep track? Keeping track of your blood sugar levels will help you and your doctor: Know if you’re meeting your blood sugar goals Learn how different foods affect your blood sugar levels Figure out how much insulin you should be taking Your doctor will tell you what to do if your blood sugar is high or low. If you take too much Humalog, your blood sugar may fall too low (hypoglycemia). If you forget to take your dose of Humalog, your blood sugar may go too high (hyperglycemia). Your blood sugar goals The American Diabetes Association recommends blood sugar goals for people with diabetes. These don’t apply to everyone, however, so work with your doctor to set the right goals for you. These goals are not applicable to pregnant women or children. These goals should be individualized. About high blood sugar One of the goals of your diabetes treatment is to keep blood suga Continue reading >>

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