Insulin Lispro: A Fast-acting Insulin Analog
Research has established the importance of maintaining blood glucose levels near normal in patients with type 1 (insulin-dependent) diabetes mellitus. Short-acting insulin analogs are designed to overcome the limitations of regular short-acting insulins. Compared with regular human insulin, the analog insulin lispro offers faster subcutaneous absorption, an earlier and greater insulin peak and a more rapid post-peak decrease. Insulin lispro begins to exert its effects within 15 minutes of subcutaneous administration, and peak levels occur 30 to 90 minutes after administration. Duration of activity is less than five hours. Rates of insulin allergy, lipodystrophy, hypoglycemia and abnormal laboratory test results are essentially the same in patients using insulin lispro and in those using regular human insulin. The Diabetes Control and Complications Trial (DCCT)1 established the importance of maintaining near-normal blood glucose levels in patients with type 1 (insulin-dependent) diabetes mellitus. In these patients, intensive therapeutic regimens have been found to delay the onset and reduce the progression of microvascular complications by 50 to 75 percent as compared with conventional regimens. Although no large-scale investigations have been completed, smaller studies have reported similar benefits for intensive therapeutic regimens in patients with type 2 (non–insulin-dependent) diabetes.2 Primary care physicians provide medical care for 75 percent of children and 90 to 95 percent of adults with diabetes.3 Regardless of the type of diabetes, improved glycemic control often can be achieved with individualized tools for patient self-management, carefully formulated nutrition plans and the use of alternative insulin regimens.4 Overview of Insulin Insulin is necessary Continue reading >>
Humalog Junior Kwikpen With Half-unit Dosing Now Available In Us
Lilly’s Humalog Junior KwikPen offers 0.5 unit dose increments in prefilled, disposable device – a win for highly insulin sensitive users Lilly’s Humalog Junior KwikPen hit the shelves of pharmacies across the US in early October, four months after Food and Drug Administration (FDA) approval. The Junior KwikPen is currently the only prefilled, disposable mealtime insulin pen that allows for dosing in half-units of insulin. These features will help children who may require lower insulin doses, as well as adults and elderly individuals who may be more sensitive to insulin. It’s encouraging to see the half-unit dosing available in a disposable, prefilled pen. Before the approval of the KwikPen, half units of insulin could only be dosed and delivered via pen through Novo Nordisk’s reusable NovoPen Echo. Since the KwikPen is prefilled, users will no longer need to remove and load cartridges to dose half-units. The Humalog Junior KwikPen contains 300 units (3 mL) of the mealtime insulin Humalog (insulin lispro) and can dose up to 30 units in a single injection. In the US, the Humalog Junior KwikPen is sold in a five-count carton. BD pen needles are recommended by the manufacturer. Lilly has submitted an application for approval of the pen in Europe. Though the decision is still pending, approval is expected later this year. Whether you have type 2 diabetes, are a caregiver or loved one of a person with type 2 diabetes, or just want to learn more, the following page provides an overview of type 2 diabetes. New to type 2 diabetes? Check out “Starting Point: Type 2 Diabetes Basics” below, which answers some of the basic questions about type 2 diabetes: what is type 2 diabetes, what are its symptoms, how is it treated, and many more! Want to learn a bit more? See ou Continue reading >>
What Are The Possible Side Effects Of Insulin Lispro (humalog, Humalog Cartridge, Humalog Kwikpen, Humalog Pen)?
HUMALOG (insulin lispro) Injection DESCRIPTION HUMALOG® (insulin lispro injection) is a rapid-acting human insulin analog used to lower blood glucose. Insulin lispro is produced by recombinant DNA technology utilizing a non-pathogenic laboratory strain of Escherichia coli. Insulin lispro differs from human insulin in that the amino acid proline at position B28 is replaced by lysine and the lysine in position B29 is replaced by proline. Chemically, it is Lys(B28), Pro(B29) human insulin analog and has the empirical formula C257H383N65O77S6 and a molecular weight of 5808, both identical to that of human insulin. HUMALOG has the following primary structure: HUMALOG is a sterile, aqueous, clear, and colorless solution. Each milliliter of HUMALOG U-100 contains insulin lispro 100 units, 16 mg glycerin, 1.88 mg dibasic sodium phosphate, 3.15 mg Metacresol, zinc oxide content adjusted to provide 0.0197 mg zinc ion, trace amounts of phenol, and Water for Injection. Insulin lispro has a pH of 7.0 to 7.8. The pH is adjusted by addition of aqueous solutions of hydrochloric acid 10% and/or sodium hydroxide 10%. Each milliliter of HUMALOG U-200 contains insulin lispro 200 units, 16 mg glycerin, 5 mg tromethamine, 3.15 mg Metacresol, zinc oxide content adjusted to provide 0.046 mg zinc ion, trace amounts of phenol, and Water for Injection. Insulin lispro has a pH of 7.0 to 7.8. The pH is adjusted by addition of aqueous solutions of hydrochloric acid 10% and/or sodium hydroxide 10%. font size A A A 1 2 3 4 5 Next What is Type 2 Diabetes? The most common form of diabetes is type 2 diabetes, formerly called non-insulin dependent diabetes mellitus or "adult onset" diabetes, so-called because it typically develops in adults over age 35, though it can develop at any age. Type 2 diabetes i Continue reading >>
You Clicked On A Page That’s Meant For Healthcare Providers.
Thought leaders discuss the AUTONOMY study These short videos, featuring well-respected leaders from the diabetes community, provide an insightful look at the AUTONOMY study, the study’s implications, and a step-by-step tutorial for the Humalog Self-titration Algorithm. AUTONOMY study author Dr. Steven Edelman reviews the study and discusses how the findings may help patients with type 2 diabetes and the healthcare providers who treat them. Professor and primary care physician Dr. Charles Shaefer discusses the practical application of the Humalog Self-titration Algorithm in the primary care setting. Starting a Patient on the Humalog Self-titration Algorithm Learn how to help your patient start mealtime insulin using the Humalog Self-titration Algorithm. Continue reading >>
Helpful Hints For Humalog:
WHAT YOU NEED TO KNOW by John Walsh, P.A., C.D.E., and Ruth Roberts, M.A. Copyright--1996 by Diabetes Services, Inc. The new, fast insulin Humalog, is finally here. Since the introduction of Lilly's new insulin, many people have been switching over. This is the first insulin produced since 1921 that can really cover most meals, and its speed of action offers users more flexibility and control. This article provides helpful hints for safety and success when starting this new product. Almost everyone who is switching to Humalog is doing so to replace their Regular insulin. Regular is often thought of as "meal" Regular or "high blood sugar" Regular, but its action time of five to eight hours more closely resembles a long-acting insulin. After switching from Regular to Humalog, many people have found that fewer units of Humalog are needed to cover the same food. Fewer units may also be needed to lower high blood sugars. Others have discovered that as meal doses are lowered, they need to raise their long-acting insulin to replace some of the lost meal dose. The Regular insulin most people take for breakfast has, in effect, been lowering their after-lunch blood sugars as well. This prolonged action is no longer seen with Humalog. Several of my (John's) patients and several diabetes colleagues have found they need extra long-acting insulin in the morning after switching in order to keep the afternoon and pre-dinner readings down. Another alternative is to use extra Humalog to cover lunch. When given before most meals, Humalog will cover these meals only during the time they are raising the blood sugar. Its action is gone before the next meal begins, and most importantly for many, before going to bed. This eliminates many nighttime lows. But with the loss of the longer action o Continue reading >>
Humalog Vs. Novolog: What’s The Difference?
The two leaders in the fast acting insulin market, Humalog and Novolog, are the most common types of fast acting insulin used by those with diabetes today. Fast Acting, mealtime insulin is a type of insulin that is injected before or right after eating. When you eat your blood glucose begins to rise. Fast acting insulin, Humalog and Novolog work to help manage these rises or spikes to keep your blood glucose levels more within range and balanced. When you use a fast acting insulin like Humalog or Novolog, you typically will continue to take a long acting insulin to help manage your levels between your meals and throughout the night. The question is though, is there really a difference between the two? Endocrinologists and other medical professionals don’t seem to really think there is, stating the two are virtually interchangeable. But that’s not really the full story. Humalog (Insulin Lispro) Insulin Lispro (Humalog) has been on the market since 1996, when it was first introduced by Eli Lily. Humalog is the first insulin analogue that was used clinically. Insulin Lispro received its name due to its structure. The difference between it and regular insulin was the switch between the lysine B28 (an amino acid) and proline B29. The formula consists of a hexametric solution available in vials and pen form. After a subcutaneous injection, the formula converts into a monomeric formula which allows it to have a fast absorption in the body. The one noted negative factor of Humalog is its short term control of glucose levels. Additionally, if it is injected and mealtime happens to be delayed, a hypoglycemic episode may occur. For Humalog to be most effective it is to be injected 15 minutes prior to the start of a meal. I recommend reading the following articles: Humalog is a Continue reading >>
Managing Blood Sugar
Everyone’s experience with mealtime insulin is different, but there are some things you can look out for. Your Humalog dose will probably change over time. Your doctor gave you a starting dose, but most people need to increase their Humalog dose over time. When you track your blood sugar every day, you will probably see different numbers all the time. These variations in your blood sugar from day to day are normal. Your blood sugar varies based on stress, what you eat, other medications, exercise, and other factors. Don't be discouraged by changes in your blood sugar. With your doctor’s input, these variations may provide learning opportunities. Testing your blood sugar When using mealtime insulin like Humalog, you must test your blood sugar (glucose) regularly. For example, you may need to test before and after meals and at bedtime. Your doctor will tell you when and how often you should test. Why keep track? Keeping track of your blood sugar levels will help you and your doctor: Know if you’re meeting your blood sugar goals Learn how different foods affect your blood sugar levels Figure out how much insulin you should be taking Your doctor will tell you what to do if your blood sugar is high or low. If you take too much Humalog, your blood sugar may fall too low (hypoglycemia). If you forget to take your dose of Humalog, your blood sugar may go too high (hyperglycemia). Your blood sugar goals The American Diabetes Association recommends blood sugar goals for people with diabetes. These don’t apply to everyone, however, so work with your doctor to set the right goals for you. These goals are not applicable to pregnant women or children. These goals should be individualized. About high blood sugar One of the goals of your diabetes treatment is to keep blood suga Continue reading >>
Important Administration Instructions Inspect HUMALOG visually before use. It should appear clear and colorless. Do not use HUMALOG if particulate matter or coloration is seen. Do NOT mix HUMALOG U-100 with other insulins when administering using a continuous subcutaneous infusion pump. Do NOT perform dose conversion when using any HUMALOG U-100 or U-200 KwikPens. The dose window shows the number of insulin units to be delivered and no conversion is needed. HUMALOG U-100 and U-200 KwikPens are designed to dial doses in increments of 1 unit. HUMALOG Junior KwikPen is designed to dial doses in 0.5 (1/2) unit increments. Do NOT mix HUMALOG U-200 with any other insulins. Do NOT administer HUMALOG U-200 using a continuous subcutaneous infusion pump (i.e., insulin pump). Do NOT administer HUMALOG U-200 intravenously. Route of Administration Subcutaneous Injection: HUMALOG U-100 or U-200 Administer the dose of HUMALOG U-100 or HUMALOG U-200 within fifteen minutes before a meal or immediately after a meal by injection into the subcutaneous tissue of the abdominal wall, thigh, upper arm, or buttocks. To reduce the risk of lipodystrophy, rotate the injection site within the same region from one injection to the next [see Adverse Reactions (6)]. HUMALOG administered by subcutaneous injection should generally be used in regimens with an intermediate- or long-acting insulin. Continuous Subcutaneous Infusion (Insulin Pump): HUMALOG U-100 ONLY Do NOT administer HUMALOG U-200 using a continuous subcutaneous infusion pump. Administer HUMALOG U-100 by continuous subcutaneous infusion into the subcutaneous tissue of the abdominal wall. Rotate infusion sites within the same region to reduce the risk of lipodystrophy [see Adverse Reactions (6.1)]. Follow healthcare professional recommendati Continue reading >>
Calculating Insulin Dose
You'll need to calculate some of your insulin doses. You'll also need to know some basic things about insulin. For example, 40-50% of the total daily insulin dose is to replace insulin overnight. Your provider will prescribe an insulin dose regimen for you; however, you still need to calculate some of your insulin doses. Your insulin dose regimen provides formulas that allow you to calculate how much bolus insulin to take at meals and snacks, or to correct high blood sugars. In this section, you will find: First, some basic things to know about insulin: Approximately 40-50% of the total daily insulin dose is to replace insulin overnight, when you are fasting and between meals. This is called background or basal insulin replacement. The basal or background insulin dose usually is constant from day to day. The other 50-60% of the total daily insulin dose is for carbohydrate coverage (food) and high blood sugar correction. This is called the bolus insulin replacement. Bolus – Carbohydrate coverage The bolus dose for food coverage is prescribed as an insulin to carbohydrate ratio. The insulin to carbohydrate ratio represents how many grams of carbohydrate are covered or disposed of by 1 unit of insulin. Generally, one unit of rapid-acting insulin will dispose of 12-15 grams of carbohydrate. This range can vary from 6-30 grams or more of carbohydrate depending on an individual’s sensitivity to insulin. Insulin sensitivity can vary according to the time of day, from person to person, and is affected by physical activity and stress. Bolus – High blood sugar correction (also known as insulin sensitivity factor) The bolus dose for high blood sugar correction is defined as how much one unit of rapid-acting insulin will drop the blood sugar. Generally, to correct a high bloo Continue reading >>
Humalog Kwikpen Side Effects
What Is Humalog Kwikpen (Concentrated)? Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Insulin lispro is a fast-acting insulin that starts to work about 15 minutes after injection, peaks in about 1 hour, and keeps working for 2 to 4 hours. Insulin lispro is used to improve blood sugar control in adults and children with diabetes mellitus. Insulin lispro is used to treat type 2 diabetes in adults. Insulin lispro is also used to treat type 1 diabetes in adults and children who are at least 3 years old. Insulin lispro may also be used for purposes not listed in this medication guide. Never share an injection pen, cartridge, or syringe with another person, even if the needle has been changed. You should not use insulin lispro if you are allergic to it, or if you are having an episode of hypoglycemia (low blood sugar). Insulin lispro should not be given to a child younger than 3 years old. Insulin lispro should not be used to treat type 2 diabetes in a child of any age. To make sure insulin lispro is safe for you, tell your doctor if you have: liver or kidney disease; or low levels of potassium in your blood (hypokalemia). Tell your doctor if you also take pioglitazone or rosiglitazone (sometimes contained in combinations with glimepiride or metformin). Taking certain oral diabetes medicines while you are using insulin may increase your risk of serious heart problems. Follow your doctor's instructions about using insulin if you are pregnant or breast-feeding a baby. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester of pregnancy. Your dose needs may also be different while you are breast-feeding. Get emergency medical help if you have signs of insulin allergy: redness or swel Continue reading >>
Humalog U-100 Insulin Subcutaneous : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - Webmd
Insulin lispro is used with a proper diet and exercise program to control high blood sugar in people with diabetes . Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke . Insulin lispro is a man-made product that is similar to human insulin . It replaces the insulin that your body would normally make. Insulin lispro starts working faster and lasts for a shorter time than regular insulin. It works by helping blood sugar ( glucose ) get into cells so your body can use it for energy. This medication is usually used with a medium- or long-acting insulin product. Insulin lispro may also be used with other oral diabetes medications (such as sulfonylureas like glyburide or glipizide ). Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor, diabetes educator, or pharmacist. Learn all preparation and usage instructions from your health care professional and the product package. Before using, check this product visually for particles or discoloration. If either is present, do not use the insulin . Insulin lispro should be clear and colorless. Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin and to avoid developing problems under the skin ( lipodystrophy ). Insulin lispro may be injected in the stomach area, the thigh, the buttocks, or the back of the upper arm. Do not inject into skin that is red, swollen, or itchy. Do not inject cold insulin because this can be painful. The insulin container you are current Continue reading >>
Humalog (insulin Lispro,insulin Lispro Protamine) Dosage, Indication, Interactions, Side Effects | Empr - The Clinical Advisor
<3yrs: not recommended. Onset approx 15 mins, peak approx 1hr, duration approx 3.54.5hrs. 3yrs: Give SC, either by injection or continuous infusion external pump. SC inj: give 15 mins before meal or immediately after a meal; use with an intermediate or long-acting insulin. Rotate inj sites. Continuous SC infusion pump: do not use diluted or mixed insulins in external pumps; change the Humalog in the reservoir at least every 7 days, change the infusion sets and insertion site at least every 3 days. Instruct patients on diet, exercise, blood or urine testing, proper administration of insulin, change in species of origin, type or purity of insulin, and management of hypoglycemia. Do not reuse or share pens, needles, cartridges, or syringes between patients. Dosage increase may be required during infection, illness, stress, trauma, and pregnancy. Dosage decrease may be needed with renal or hepatic dysfunction. Pregnancy (Cat.B). Nursing mothers. Concomitant thiazolidinediones (TZDs) may cause fluid retention and heart failure; consider dose reduction or discontinue TZDs. Potentiated by oral antidiabetic agents, pramlintide, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, propoxyphene, salicylates, somatostatin analog, sulfonamide antibiotics. Antagonized by corticosteroids, isoniazid, niacin, danazol, diuretics, thiazides, phenothiazines, sympathomimetics, somatropin, thyroid hormones, estrogens, progestogens, atypical antipsychotics. Variable effects with -blockers, clonidine, lithium salts, alcohol, pentamidine. When mixing insulin lispro with other insulins, draw insulin lispro into syringe first and inject mixture immediately. Hypoglycemia, hypokalemia, local or systemic allergy, lipodystrophy, edema. Humalog Mix75/25, Humalog vials (10mL)1; Humalog Mix, Hum Continue reading >>
Humalog is a prescription medication used to treat type 1 diabetes. It can also be used to treat some patients with type 2 diabetes. Humalog is a fast-acting form of insulin and is often used with other forms of insulin. Humalog is administered with meals. Insulin is naturally produced by the body to control the amount of sugar (glucose) in the blood. In patients with type 1 diabetes, the body does not make insulin and must be replaced by injections of insulin. In patients with type 2 diabetes, the body makes insulin but does not use it efficiently or appropriately. Common side effects of Humalog include redness, swelling, or itching in the place where you injected Humalog or changes in the feel of your skin such as skin thickening or a little indentation in the skin. Humalog can also cause low blood sugar, which can cause drowsiness and dizziness. Do not drive or operate heavy machinery until you know how Humalog affects you. Diabetes mellitus (DM or, simply, diabetes) refers to a group of diseases that affect how your body uses sugar (glucose). Glucose comes from the foods you eat. Glucose is essential to health because it is an important source of energy for the cells that make up your muscles and tissues and it is the brain's main source of fuel. If you have diabetes, no matter what type, it means you have too much glucose in your blood. Too much glucose can lead to serious health problems, including damage to the eyes, kidneys, and nerves, heart disease, and stroke. Insulin is a hormone that helps the glucose get into your cells to give them energy. With type 2 diabetes, the more common type of diabetes, your body does not make or use insulin well. Without enough insulin, the glucose stays in your blood. Type 2 diabetes can develop at any age, though it is more com Continue reading >>
Admelog, Humalog (insulin Lispro) Dosing, Indications, Interactions, Adverse Effects, And More
100 units/mL (Humalog KwikPen; Humalog Junior KwikPen 3mL pen or cartridge) KwikPen dose increment: 1 unit; maximum dose/injection is 60 units Junior KwikPen dose increment: 0.5 unit; maximum dose/injection is 30 units Rapid-acting human insulin analogue indicated to improve glycemic control in adults and children with type 1 or 2 diabetes mellitus Usual daily maintenance range is 0.5-1 unit/kg/day in divided doses; nonobese may require 0.4-0.6 unit/kg/day; obese may require 0.8-1.2 units/kg/day Intermediate- or long-acting insulin: Approximately one-third of the total daily insulin requirements SC Rapid-acting or short-acting, premeal insulin should be used to satisfy the remainder of the daily insulin requirements Intermediate- or long-acting insulin: 10 units/day SC (or 0.1-0.2 unit/kg/day) at bedtime generally recommended Short-acting insulin: If necessary, start up to 4 units, 0.1 unit/kg SC within 15 min before each meal, or 10% basal dose; if A1C <8%, consider decreasing basal insulin dose by same amount Increase by 1-2 units or 10-15% qWeek or q2Weeks once self-monitoring of blood glucose (SMBG) is achieved (ADA guidelines 2018) Dose adjustment and increased frequency of glucose monitoring Coadministration of drugs that increase the risk of hypoglycemia, and drugs that may increase or decrease blood glucose lowering effects Renal and hepatic impairment: May increase risk for hypoglycemia Do not mix SC injection with insulin preparations other than NPH insulin Do not mix IV or continuous SC infusions with any other insulins Do NOT transfer Humalog U-200 from the KwikPen to a syringe for administration; the markings on the insulin syringe will not measure the dose correctly and can result in overdosage and severe hypoglycemia Do NOT perform dose conversion when u Continue reading >>
What's The Most Insulin To Take?
I am taking Humalog and Lantus insulins: 40 units of Lantus and 85 to 90 units of Humalog each day. My morning blood sugar is in the 180 to 200 range. I have had several bad bouts of hypoglycemia and am scared that they could occur while I sleep. Is there a maximum amount of insulin I should take? Should I take an additional dose of Humalog at bedtime? Would different brands of insulin be more effective? Continue reading >>