Humalog Vs. Novolog: Important Differences And More
Humalog and Novolog are two diabetes medications. Humalog is the brand-name version of insulin lispro, and Novolog is the brand-name version of insulin aspart. These drugs both help control blood glucose (sugar) in people with type 1 and type 2 diabetes. Humalog and Novolog are both rapid acting. That means they work more quickly than other types of insulin. There are important distinctions between Humalog and Novolog, however, and the drugs are not directly interchangeable. Check out this comparison so you can work with your doctor to choose a drug that’s right for you. Insulin is injected under your skin fat. It’s the most common type of treatment for type 1 diabetes because it works quickly. It’s also the only type of diabetes medication that’s absorbed into the bloodstream. Humalog and Novolog are both equivalent to the insulin made in your body. Unlike oral diabetes drugs, insulin provides fast relief for changes in your blood sugar. The type of insulin your doctor prescribes depends on how often and how much your blood sugar fluctuates each day. The table below provides quick facts at a glance. Brand name Humalog Novolog What is the generic drug? insulin lispro insulin aspart Is a generic version available? no no What does it treat? type 1 and type 2 diabetes type 1 and type 2 diabetes What form does it come in? solution for injection solution for injection What strengths does it come in? • 3-mL cartridges • 3-mL prefilled KwikPen • 3-mL vials • 10-mL vials • 3-mL FlexPen • 3-mL FlexTouch • 3-mL PenFill cartridges • 10-mL vials What is the typical length of treatment? long-term long-term How do I store it? Refrigerate at 36° to 46°F (2° to 8°C). Do not freeze the drug. Refrigerate at 36° to 46°F (2° to 8°C). Do not freeze the drug. Continue reading >>
What Are The Side Effects Of Humalog Insulin Diabetes Medication?
Insulin is released by the pancreas naturally to help the body store or use glucose it gets from food. In an individual with diabetes, his or her pancreas doesn’t make adequate insulin to meet the body’s requirement or the body can’t utilize the insulin produced. Consequently, the glucose isn’t used and stored as expected, and accumulates in the bloodstream; this is when Humalog comes to lower blood glucose levels in a patient with type 1 diabetes. What is Humalog? It is a diabetic medication which is administered through injections and it is the brand name version of insulin Lispro. Humalog Mix 75/25 and Mix 50/50 contain the following mixtures of insulin: Lispro Lispro Protamine The drug is fast-acting insulin also known as meal time insulin and is taken immediately before a meal or after a meal; to be precise, This insulin is taken 15 minutes prior eating or right after a meal. This means it works quickly (15minues after taking it) than the other types of insulin. When you eat, blood glucose levels rise; this is when the pancreas produces more insulin to aid in offsetting and balancing the rising blood sugar levels. Nonetheless, if you have diabetes, the body does not release enough insulin naturally. The goal of Humalog is to take over the role of the natural insulin to keep the blood glucose levels within the recommended range after consuming a meal by: • Helping some tissues in your body to preserve glucose in their cells • Preventing the liver from releasing more glucose • Hindering the breakdown of proteins and fats • Helping to control the overall production as well as breakdown of sugar in your body If the medical care provider prescribes this rapid-acting insulin, you will require a long-acting as well to aid in managing the blood sugar level Continue reading >>
Welcome To The Humalog® Family Of Insulins.
Humalog® is used to treat people with diabetes for the control of blood sugar. Humalog® Mix75/25™(75% insulin lispro protamine suspension and 25% insulin lispro injection) and Humalog® Mix50/50™(50% insulin lispro protamine suspension and 50% insulin lispro injection) are used to treat adults with diabetes for the control of high blood sugar. Do not share your Humalog, Humalog Junior, Humalog Mix75/25, or Humalog Mix50/50 KwikPens, cartridges, reusable pen compatible with Lilly 3 mL cartridges, or syringes with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them. The Humalog contained in the Humalog U-200 KwikPen should ONLY be injected with the Humalog U-200 KwikPen. Do NOT withdraw Humalog U-200 from the pen using a syringe. It could result in an overdose causing severe low blood sugar which may put your life in danger. Do not change the insulin you use without talking to your healthcare provider. Changes may make you more likely to experience low or high blood sugar. Changes should be made cautiously under the supervision of your healthcare provider. When used in a pump, do not mix or dilute Humalog U-100 with any other insulin or liquid. Do NOT use Humalog U-200, Humalog Mix75/25 or Humalog Mix50/50 in a pump. These insulins start working faster than other insulins that contain regular human insulin. You should take Humalog within fifteen minutes before eating or right after eating a meal. You should take Humalog Mix75/25 and Humalog Mix50/50 within fifteen minutes before eating. Do not use Humalog Mix75/25 or Humalog Mix50/50 if they have solid particles or clumps in them. Humalog Mix75/25 and Humalog Mix50/50 should be mixed carefully before each use and should be cloudy or mi Continue reading >>
Types Of Insulin For Diabetes Treatment
Many forms of insulin treat diabetes. They're grouped by how fast they start to work and how long their effects last. The types of insulin include: Rapid-acting Short-acting Intermediate-acting Long-acting Pre-mixed What Type of Insulin Is Best for My Diabetes? Your doctor will work with you to prescribe the type of insulin that's best for you and your diabetes. Making that choice will depend on many things, including: How you respond to insulin. (How long it takes the body to absorb it and how long it remains active varies from person to person.) Lifestyle choices. The type of food you eat, how much alcohol you drink, or how much exercise you get will all affect how your body uses insulin. Your willingness to give yourself multiple injections per day Your age Your goals for managing your blood sugar Afrezza, a rapid-acting inhaled insulin, is FDA-approved for use before meals for both type 1 and type 2 diabetes. The drug peaks in your blood in about 15-20 minutes and it clears your body in 2-3 hours. It must be used along with long-acting insulin in people with type 1 diabetes. The chart below lists the types of injectable insulin with details about onset (the length of time before insulin reaches the bloodstream and begins to lower blood sugar), peak (the time period when it best lowers blood sugar) and duration (how long insulin continues to work). These three things may vary. The final column offers some insight into the "coverage" provided by the different insulin types in relation to mealtime. Type of Insulin & Brand Names Onset Peak Duration Role in Blood Sugar Management Rapid-Acting Lispro (Humalog) 15-30 min. 30-90 min 3-5 hours Rapid-acting insulin covers insulin needs for meals eaten at the same time as the injection. This type of insulin is often used with Continue reading >>
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When Do Humalog And Novolog Insulins Really Work?
When do Humalog and Novolog insulins really work? See also: Humalog & Heat and User's Reports A problem associated with the use of rapid insulins is that situations occur that cause people to perceive them as faster than they really are. For example, a person may feel perfectly normal at 70 mg/dl (3.9 mmol), take a bolus of rapid insulin for a meal, and a few minutes later begin to shake, sweat and have trouble thinking. Though the timing of the symptoms gives the impression that rapid insulin is responsible and acts very quickly, the symptoms are unlikely to be caused by the rapid insulin just given. More likely, another insulin given earlier is causing the blood sugar to drop. A drop of only a few mg/dl causes a person to go from feeling normal to feeling low. Because the meal bolus was just given, it often receives the blame for a low caused by an insulin that was given earlier. The kinetics of an insulin are when that insulin can be measured in the bloodstream, whereas an insulin's dynamics are when it actually affects the blood sugar. After an injection, peak levels of Humalog and Novolog insulins are seen in the bloodstream about 45 minutes later, as shown by the dashed kinetic line to the right. However, the effect on your blood sugar is not nearly this quick. The solid dynamic line to the right shows when these insulins are actually lowering the blood sugar. The maximum effect on lowering the glucose level is not seen until 2 hours after an injection and continues for over 4 hours. Another situation often seems to confirm for many the false impression that a rapid insulin is really rapid. This occurs when a carb or correction bolus is given and a low blood sugar begins only an hour or two later. Here, the rapid insulin is likely at fault, but again the low bloo Continue reading >>
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Helpful Hints For Humalog:
WHAT YOU NEED TO KNOW by John Walsh, P.A., C.D.E., and Ruth Roberts, M.A. Copyright--1996 by Diabetes Services, Inc. The new, fast insulin Humalog, is finally here. Since the introduction of Lilly's new insulin, many people have been switching over. This is the first insulin produced since 1921 that can really cover most meals, and its speed of action offers users more flexibility and control. This article provides helpful hints for safety and success when starting this new product. Almost everyone who is switching to Humalog is doing so to replace their Regular insulin. Regular is often thought of as "meal" Regular or "high blood sugar" Regular, but its action time of five to eight hours more closely resembles a long-acting insulin. After switching from Regular to Humalog, many people have found that fewer units of Humalog are needed to cover the same food. Fewer units may also be needed to lower high blood sugars. Others have discovered that as meal doses are lowered, they need to raise their long-acting insulin to replace some of the lost meal dose. The Regular insulin most people take for breakfast has, in effect, been lowering their after-lunch blood sugars as well. This prolonged action is no longer seen with Humalog. Several of my (John's) patients and several diabetes colleagues have found they need extra long-acting insulin in the morning after switching in order to keep the afternoon and pre-dinner readings down. Another alternative is to use extra Humalog to cover lunch. When given before most meals, Humalog will cover these meals only during the time they are raising the blood sugar. Its action is gone before the next meal begins, and most importantly for many, before going to bed. This eliminates many nighttime lows. But with the loss of the longer action o Continue reading >>
What Are The Possible Side Effects Of Insulin Lispro (humalog, Humalog Cartridge, Humalog Kwikpen, Humalog Pen)?
HUMALOG (insulin lispro) Injection DESCRIPTION HUMALOG® (insulin lispro injection) is a rapid-acting human insulin analog used to lower blood glucose. Insulin lispro is produced by recombinant DNA technology utilizing a non-pathogenic laboratory strain of Escherichia coli. Insulin lispro differs from human insulin in that the amino acid proline at position B28 is replaced by lysine and the lysine in position B29 is replaced by proline. Chemically, it is Lys(B28), Pro(B29) human insulin analog and has the empirical formula C257H383N65O77S6 and a molecular weight of 5808, both identical to that of human insulin. HUMALOG has the following primary structure: HUMALOG is a sterile, aqueous, clear, and colorless solution. Each milliliter of HUMALOG U-100 contains insulin lispro 100 units, 16 mg glycerin, 1.88 mg dibasic sodium phosphate, 3.15 mg Metacresol, zinc oxide content adjusted to provide 0.0197 mg zinc ion, trace amounts of phenol, and Water for Injection. Insulin lispro has a pH of 7.0 to 7.8. The pH is adjusted by addition of aqueous solutions of hydrochloric acid 10% and/or sodium hydroxide 10%. Each milliliter of HUMALOG U-200 contains insulin lispro 200 units, 16 mg glycerin, 5 mg tromethamine, 3.15 mg Metacresol, zinc oxide content adjusted to provide 0.046 mg zinc ion, trace amounts of phenol, and Water for Injection. Insulin lispro has a pH of 7.0 to 7.8. The pH is adjusted by addition of aqueous solutions of hydrochloric acid 10% and/or sodium hydroxide 10%. font size A A A 1 2 3 4 5 Next What is Type 2 Diabetes? The most common form of diabetes is type 2 diabetes, formerly called non-insulin dependent diabetes mellitus or "adult onset" diabetes, so-called because it typically develops in adults over age 35, though it can develop at any age. Type 2 diabetes i Continue reading >>
You Clicked On A Page That’s Meant For Healthcare Providers.
Humalog® is a rapid-acting human insulin analog indicated to improve glycemic control in adults and children with diabetes mellitus. Humalog® Mix75/25™ (75% insulin lispro protamine suspension and 25% insulin lispro injection) and Humalog® Mix50/50™ (50% insulin lispro protamine suspension and 50% insulin lispro injection) are indicated in the treatment of adults with diabetes mellitus for the control of hyperglycemia. Never Share a Humalog KwikPen, Humalog Junior KwikPen, Humalog Mix75/25 KwikPen, or Humalog Mix50/50 KwikPen, Cartridge, Reusable Pen Compatible with Lilly 3 mL Cartridges, or Syringe Between Patients: Humalog, Humalog Mix75/25, and Humalog Mix50/50 KwikPens, cartridges, and reusable pens compatible with Lilly 3 mL cartridges must never be shared between patients, even if the needle is changed. Patients using Humalog, Humalog Mix75/25, or Humalog Mix50/50 vials must never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens. Changes in Insulin Regimen: Changes may affect glycemic control and predispose to hypoglycemia or hyperglycemia. These changes should be made cautiously under close medical supervision and the frequency of blood glucose monitoring should be increased. Hypoglycemia: Severe hypoglycemia may be life threatening and can cause seizures or death. Hypoglycemia is the most common adverse reaction of Humalog, Humalog Mix75/25, and Humalog Mix50/50. The patient’s ability to concentrate and react may be impaired as a result of hypoglycemia. Hypoglycemia can happen suddenly and symptoms may vary for each person and may change over time. Early warning symptoms of hypoglycemia may be different or less pronounced under conditions such as long-standing diabetes, diabetic nerve disease, Continue reading >>
Why Humalog® U-100?
You may have been taking a long-acting insulin for a while now. So why did your doctor prescribe another insulin? Well, it’s to help control the blood sugar spikes that happen naturally when you eat. Everyone gets them, but when you have diabetes you may need extra help controlling them. That’s where Humalog comes in. Humalog is different than your long-acting insulin. Long-acting insulin helps control your blood sugar throughout the whole day. Humalog is fast-acting insulin—it helps control the blood sugar spikes that happen naturally when you eat. Humalog is available in the Humalog U-100 KwikPen, which is portable and easy to use. And, since it shouldn’t be refrigerated after the first use, you can take it just about anywhere. Continue reading >>
Insulin Lispro Injection
Insulin lispro is used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood). It is also used to treat people with type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood) who need insulin to control their diabetes. In patients with type 1 diabetes, insulin lispro is always used with another type of insulin, unless it is used in an external insulin pump. In patients with type 2 diabetes, insulin lispro may be used with another type of insulin or with oral medication(s) for diabetes. Insulin lispro is a short-acting, man-made version of human insulin. Insulin lispro works by replacing the insulin that is normally produced by the body and by helping move sugar from the blood into other body tissues where it is used for energy. It also stops the liver from producing more sugar. Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Using medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes. Insulin lispro comes as a solution (liquid) and a suspension (liquid Continue reading >>
Humalog (lispro) For Type 2 Diabetes.
Second University of Naples, Department of Cardio-thoracic and Respiratory Sciences, Piazza L. Miraglia 2, 80138 Naples, Italy. [email protected] Expert Opin Biol Ther. 2012 Nov;12(11):1541-50. INTRODUCTION: Type 2 diabetes is a chronic and progressive disease, and ultimately, most patients will require insulin therapy for the optimization of their glycemic control. AREAS COVERED: We review the recent literature investigating the efficacy and safety of the insulin analogue lispro in type 2 diabetes. Relevant publications were identified by means of a PubMed literature search in the period January 1990 to May 2012. We included randomized controlled trials (RCTs), which included at least one arm evaluating insulin lispro in type 2 diabetes. EXPERT OPINION: Insulin is the most effective therapy for reducing hyperglycemia: when the desired decrease of HbA1c is 1.5%, it is unlikely than any other antidiabetes drug may work as better as insulin. The pharmacodynamic and pharmacokinetic profiles of lispro analogues offer discrete advantage over human insulin. The preliminary results of comparative RCTs versus insulin glargine or insulin detemir indicate that insulin lispro protamine suspension (ILPS) has a similar effect on glucose control and the risk of hypoglycemia while using lower doses when injected once a day. Lispro/ILPS premixed formulations can be injected immediately before a meal because they are absorbed more rapidly than premixed human insulin, thus allowing more flexibility with insulin therapy. Continue reading >>
Admelog, Humalog (insulin Lispro) Dosing, Indications, Interactions, Adverse Effects, And More
100 units/mL (Humalog KwikPen; Humalog Junior KwikPen 3mL pen or cartridge) KwikPen dose increment: 1 unit; maximum dose/injection is 60 units Junior KwikPen dose increment: 0.5 unit; maximum dose/injection is 30 units Rapid-acting human insulin analogue indicated to improve glycemic control in adults and children with type 1 or 2 diabetes mellitus Usual daily maintenance range is 0.5-1 unit/kg/day in divided doses; nonobese may require 0.4-0.6 unit/kg/day; obese may require 0.8-1.2 units/kg/day Intermediate- or long-acting insulin: Approximately one-third of the total daily insulin requirements SC Rapid-acting or short-acting, premeal insulin should be used to satisfy the remainder of the daily insulin requirements Intermediate- or long-acting insulin: 10 units/day SC (or 0.1-0.2 unit/kg/day) at bedtime generally recommended Short-acting insulin: If necessary, start up to 4 units, 0.1 unit/kg SC within 15 min before each meal, or 10% basal dose; if A1C <8%, consider decreasing basal insulin dose by same amount Increase by 1-2 units or 10-15% qWeek or q2Weeks once self-monitoring of blood glucose (SMBG) is achieved (ADA guidelines 2018) Dose adjustment and increased frequency of glucose monitoring Coadministration of drugs that increase the risk of hypoglycemia, and drugs that may increase or decrease blood glucose lowering effects Renal and hepatic impairment: May increase risk for hypoglycemia Do not mix SC injection with insulin preparations other than NPH insulin Do not mix IV or continuous SC infusions with any other insulins Do NOT transfer Humalog U-200 from the KwikPen to a syringe for administration; the markings on the insulin syringe will not measure the dose correctly and can result in overdosage and severe hypoglycemia Do NOT perform dose conversion when u Continue reading >>
Humalog (insulin Lispro)
Humalog is the brand name for insulin lispro, which is an analog insulin produced in a laboratory using recombinant DNA technology. At this time, there are no generic versions available for this form of insulin. Humalog is produced by Eli Lilly pharmaceutical company. This insulin can be used by adults with either type 1 or type 2 diabetes and by children over three years old who have type 1 diabetes. According to Drugs.com, “it should not be used to treat type 2 diabetes in a child of any age.” Humalog achieved FDA approval in 1996 and was the first rapid-acting (aka fast-acting) insulin on the market. The rapid-acting class of insulins start working faster than regular human insulin. As with the other rapid-acting (aka fast-acting) insulins (i.e. Novolog and Apidra), Humalog starts working about 15 minutes after injection, reaches its peak about an hour after injection, and is gone from your system within two to four hours. These are just approximate or average times, however; everyone’s body is different, so be sure to check your blood sugar levels before and after injecting to learn how your body handles Humalog. Humalog is considered a mealtime insulin, unless you’re using it in an infusion pump. Those with pumps may use Humalog as their basal insulin as well as for boluses, as needed. If you’re not using a pump, however, you’ll likely be prescribed a longer-acting insulin to use in addition to Humalog. Several Forms of Humalog Are Available Humalog comes in different strengths and mixtures. Each has its own attributes and warnings. Humalog U-100 Available in a KwikPen, vial and syringe, HumaPen LUXURA HD (for children or small adults who need half-unit doses), and in a pump. When used in a pump, do not mix or dilute with any other insulin or liquid. Do Continue reading >>
Humalog Side Effects
Generic Name: insulin lispro (IN soo lin LISS pro) Brand Names: HumaLOG, HumaLOG Cartridge, HumaLOG KwikPen, HumaLOG KwikPen (Concentrated) What is Humalog? Humalog (insulin lispro) is a fast-acting insulin that starts to work about 15 minutes after injection, peaks in about 1 hour, and keeps working for 2 to 4 hours. Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Humalog is used to improve blood sugar control in adults and children with diabetes mellitus. Humalog is used to treat type 2 diabetes in adults. Humalog is also used to treat type 1 diabetes in adults and children who are at least 3 years old. Important information Humalog is a fast-acting insulin that begins to work very quickly. If you use this medication with meal, use it within 15 minutes before or just after you eat. Never share an injection pen, cartridge, or syringe with another person, even if the needle has been changed. You should not use Humalog if you are having an episode of hypoglycemia (low blood sugar). Humalog is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels. Before taking this medicine You should not use Humalog if you are allergic to insulin, or if you are having an episode of hypoglycemia (low blood sugar). Humalog should not be given to a child younger than 3 years old. Humalog should not be used to treat type 2 diabetes in a child of any age. To make sure Humalog is safe for you, tell your doctor if you have: liver or kidney disease; or low levels of potassium in your blood (hypokalemia). Tell your doctor if Continue reading >>
Humalog Vs. Novolog: What’s The Difference?
The two leaders in the fast acting insulin market, Humalog and Novolog, are the most common types of fast acting insulin used by those with diabetes today. Fast Acting, mealtime insulin is a type of insulin that is injected before or right after eating. When you eat your blood glucose begins to rise. Fast acting insulin, Humalog and Novolog work to help manage these rises or spikes to keep your blood glucose levels more within range and balanced. When you use a fast acting insulin like Humalog or Novolog, you typically will continue to take a long acting insulin to help manage your levels between your meals and throughout the night. The question is though, is there really a difference between the two? Endocrinologists and other medical professionals don’t seem to really think there is, stating the two are virtually interchangeable. But that’s not really the full story. Humalog (Insulin Lispro) Insulin Lispro (Humalog) has been on the market since 1996, when it was first introduced by Eli Lily. Humalog is the first insulin analogue that was used clinically. Insulin Lispro received its name due to its structure. The difference between it and regular insulin was the switch between the lysine B28 (an amino acid) and proline B29. The formula consists of a hexametric solution available in vials and pen form. After a subcutaneous injection, the formula converts into a monomeric formula which allows it to have a fast absorption in the body. The one noted negative factor of Humalog is its short term control of glucose levels. Additionally, if it is injected and mealtime happens to be delayed, a hypoglycemic episode may occur. For Humalog to be most effective it is to be injected 15 minutes prior to the start of a meal. I recommend reading the following articles: Humalog is a Continue reading >>