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How Quickly Does Metformin Work

Metformin Weight Loss – Does It Work?

Metformin Weight Loss – Does It Work?

Metformin weight loss claims are something that are often talked about by health professionals to be one of the benefits of commencing metformin therapy, but are they true? At myheart.net we’ve helped millions of people through our articles and answers. Now our authors are keeping readers up to date with cutting edge heart disease information through twitter. Follow Dr Ahmed on Twitter @MustafaAhmedMD Metformin is possibly one of the most important treatments in Type II Diabetes, so the question of metformin weight loss is of the utmost importance, as if true it could provide a means to lose weight as well as control high sugar levels found in diabetes. What is Metformin? Metformin is an oral hypoglycemic medication – meaning it reduces levels of sugar, or more specifically glucose in the blood. It is so effective that the American Diabetes Association says that unless there is a strong reason not to, metformin should be commenced at the onset of Type II Diabetes. Metformin comes in tablet form and the dose is gradually increased until the maximum dose required is achieved. How Does Metformin Work & Why Would it Cause Weight Loss? Metformin works by three major mechanisms – each of which could explain the “metformin weight loss” claims. These are: Decrease sugar production by the liver – the liver can actually make sugars from other substances, but metformin inhibits an enzyme in the pathway resulting in less sugar being released into the blood. Increase in the amount of sugar utilization in the muscles and the liver – Given that the muscles are a major “sink” for excess sugar, by driving sugar into them metformin is able to reduce the amount of sugar in the blood. Preventing the breakdown of fats (lipolysis) – this in turn reduces the amount of fatt Continue reading >>

Description And Brand Names

Description And Brand Names

Drug information provided by: Micromedex US Brand Name Fortamet Glucophage Glucophage XR Glumetza Riomet Descriptions Metformin is used to treat high blood sugar levels that are caused by a type of diabetes mellitus or sugar diabetes called type 2 diabetes. With this type of diabetes, insulin produced by the pancreas is not able to get sugar into the cells of the body where it can work properly. Using metformin alone, with a type of oral antidiabetic medicine called a sulfonylurea, or with insulin, will help to lower blood sugar when it is too high and help restore the way you use food to make energy. Many people can control type 2 diabetes with diet and exercise. Following a specially planned diet and exercise will always be important when you have diabetes, even when you are taking medicines. To work properly, the amount of metformin you take must be balanced against the amount and type of food you eat and the amount of exercise you do. If you change your diet or exercise, you will want to test your blood sugar to find out if it is too low. Your doctor will teach you what to do if this happens. Metformin does not help patients does not help patients who have insulin-dependent or type 1 diabetes because they cannot produce insulin from their pancreas gland. Their blood glucose is best controlled by insulin injections. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Tablet Tablet, Extended Release Solution Copyright © 2017 Truven Health Analytics Inc. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Continue reading >>

How Long Does It Take To Get Pregnant With Metformin For Pcos Woman?

How Long Does It Take To Get Pregnant With Metformin For Pcos Woman?

Metformin is a multiplier. It can treat insulin resistance, if you have it, and help you lose weight. (In my case, mostly by making me too nauseous to eat.) Both things can make you slightly more likely to ovulate. It also decreases your risk of developing diabetes in the future. However, metformin alone isn't a fertility treatment. It is usually combined with other drugs, like Clomid, Femera, or injectable medications, to stimulate ovulation. Your doctors may try you on metformin alone for a short period of time, usually 3 months or less. If you don't become pregnant after that, they'll usually start the other medications. The bad news is that no one can predict exactly how long it will take you to get pregnant. This is one of the worst parts of infertility. I have been through it. The intense frustration of not knowing how long I would have to keep trying drove me nuts. The good news is that PCOS is very treatable. If your doctors are willing to start with just metformin, then your case is probably also fairly mild. For younger women with PCOS, success rates are very high. Hang in there! And yes, metformin is terrible. You aren't imagining how bad you feel. The side effects will probably let up shortly. If you feel really exhausted, ask your doctor about adding a B12 supplement to your diet. Metformin causes a B12 deficiency in about 30% of patients[1], which can make you feel tired. Continue reading >>

Metformin

Metformin

A popular oral drug for treating Type 2 diabetes. Metformin (brand name Glucophage, Glucophage XR, Glumetza, Riomet) is a member of a class of drugs called biguanides that helps lower blood glucose levels by improving the way the body handles insulin — namely, by preventing the liver from making excess glucose and by making muscle and fat cells more sensitive to available insulin. Metformin not only lowers blood glucose levels, which in the long term reduces the risk of diabetic complications, but it also lowers blood cholesterol and triglyceride levels and does not cause weight gain the way insulin and some other oral blood-glucose-lowering drugs do. Overweight, high cholesterol, and high triglyceride levels all increase the risk of developing heart disease, the leading cause of death in people with Type 2 diabetes. Another advantage of metformin is that it does not cause hypoglycemia (low blood glucose) when it is the only diabetes medicine taken. Metformin is typically taken two to three times a day, with meals. The extended-release formula (Glucophage XR) is taken once a day, with the evening meal. The most common side effects of metformin are nausea and diarrhea, which usually go away over time. A more serious side effect is a rare but potentially fatal condition called lactic acidosis, in which dangerously high levels of lactic acid build up in the bloodstream. Lactic acidosis is most likely to occur in people with kidney disease, liver disease, or congestive heart failure, or in those who drink alcohol regularly. (If you have more than four alcoholic drinks a week, metformin may not be the best medicine for you.) Unfortunately, many doctors ignore these contraindications (conditions that make a particular treatment inadvisable) and prescribe metformin to people Continue reading >>

Metformin: Uses, Action, Dosage, Side Effect And Brand Information

Metformin: Uses, Action, Dosage, Side Effect And Brand Information

What is metformin used for? Controlling blood sugar levels in adults, adolescents and children aged 10 years and over with type 2 diabetes. Metformin is used when diet alone has failed to fully control blood sugar. It may be used on its own, in combination with other oral antidiabetic medicines, or with insulin. Polycystic ovary syndrome (PCOS). This is an off-licence use of metformin, so you won't find it mentioned in the information leaflets that come with the medicine. However, metformin is a widely used and established treatment option for this condition. How does metformin work? In type 2 diabetes the cells in the body, particularly muscle, fat and liver cells, become resistant to the action of insulin. Insulin is the main hormone responsible for controlling the level of sugar (glucose) in the blood. It makes cells in the body remove sugar from the blood. When the cells are resistant to insulin this makes blood sugar levels rise too high. Metformin hydrochloride is a type of antidiabetic medicine called a biguanide. It works in a number of ways to lower blood sugar levels in people with type 2 diabetes. Firstly, it increases the sensitivity of muscle cells to insulin. This enables these cells to remove sugar from the blood more effectively. Secondly, it reduces the amount of sugar produced by cells in the liver. Finally, it delays the absorption of sugar from the intestines into the bloodstream after eating so that there is less of a spike in blood sugar levels after meals. Metformin is taken regularly every day to help control blood sugar levels both between and directly after meals. In polycystic ovary syndrome or PCOS many women have high insulin levels, and as a result their cells become resistant to the action of insulin. The high insulin levels also cause an Continue reading >>

Wait Times: How Long Until Your Med Begins Working

Wait Times: How Long Until Your Med Begins Working

Photography by Mike Watson Images/Thinkstock There are many type 2 medications, and each drug class works in the body in a different way. Here’s a quick guide to help you understand how long each drug will generally take to work: These short-acting oral medications, taken with meals, block the breakdown of complex sugars into simple sugars in the gastrointestinal (GI) tract. “Simple sugars are more easily absorbed and cause the blood sugar to ultimately go up,” Sam Ellis, PharmD, BCPS, CDE, associate professor in the Department of Clinical Pharmacy at the University of Colorado says. These drugs are minimally absorbed into the blood, so a certain blood level concentration is not necessary for them to work. You will see the effect immediately with the first dose. “You take it before a meal, and with that meal you see the effect,” says George Grunberger, MD, FACP, FACE, President of the American Association of Clinical Endocrinologists. While researchers aren’t exactly sure how these oral medications work, it’s likely that the meds block some absorption of glucose in the GI tract. “You’ll see most of the effect in the first week with these drugs,” says Ellis. alogliptin, linagliptin, saxagliptin, sitagliptin These drugs work to block the enzyme responsible for the breakdown of a specific gut hormone that helps the body produce more insulin when blood glucose is high and reduces the amount of glucose produced by the liver. Take a DPP-4 inhibitor (they come in pill form) and it’ll work pretty fast—you’ll see the full effect in about a week. “It’s blocking that enzyme after the first dose a little bit, but by the time you get out to dose five, you’re blocking the majority of that enzyme,” Ellis says. albiglutide, dulaglutide, exenatide, exe Continue reading >>

Can Metformin Help With Weight Loss?

Can Metformin Help With Weight Loss?

Metformin is a drug prescribed to manage blood sugar levels in people with type 2 diabetes. You may have heard that metformin can also help you lose weight. But is it true? The answer is a resounding maybe. Here’s what you should know about what metformin can do for weight loss, as well as why your doctor may prescribe it for you. According to research, metformin can help some people lose weight. However, it’s not clear why metformin may cause weight loss. One theory is that it may prompt you to eat less by reducing your appetite. It may also change the way your body uses and stores fat. Although studies have shown that metformin may help with weight loss, the drug is not a quick-fix solution. According to one long-term study, the weight loss from metformin tends to occur gradually over one to two years. The amount of weight lost also varies from person to person. In the study, the average amount of weight lost after two or more years was four to seven pounds. Taking the drug without following other healthy habits may not lead to weight loss. Individuals who follow a healthy diet and exercise while taking metformin tend to lose the most weight. This may be because metformin is thought to boost how many calories you burn during exercise. If you don’t exercise, you likely won’t have this benefit. In addition, any weight loss you have may only last as long as you take the medication. That means if you stop taking metformin, there’s a good chance you will return to your original weight. And even while you’re still taking the drug, you may slowly gain back any weight you’ve lost. In other words, metformin may not be the magic diet pill some people have been waiting for. It has been shown to reduce weight in some, but not others. One of the benefits of metformin Continue reading >>

Timing Your Metformin Dose

Timing Your Metformin Dose

The biggest problem many people have with Metformin is that it causes such misery when it hits their stomachs that they can't keep taking it even though they know it is the safest and most effective of all the oral diabetes drugs. In many cases all that is needed is some patience. After a rocky first few days many people's bodies calm down and metformin becomes quite tolerable. If you are taking the regular form of Metformin with meals and still having serious stomach issues after a week of taking metformin, ask your doctor to prescribe the extended release form--metformin ER or Glucophage XR. The extended release form is much gentler in its action. If that still doesn't solve your problem, there is one last strategy that quite a few of us have found helpful. It is to take your metformin later in the day, after you have eaten a meal or two. My experience with metformin--and this has been confirmed by other people--is that it can irritate an empty stomach, but if you take it when the stomach contains food it will behave. There are some drugs where it matters greatly what time of day you take the drug. Metformin in its extended release form is not one of them. As the name suggests, the ER version of the pill slowly releases the drug into your body over a period that, from my observations, appears to last 8 to 12 hours. Though it is supposed to release over a full 24 hours, this does not appear to be the case, at least not with the generic forms my insurer will pay for. Because there seems to be a span of hours when these extended release forms of metformin release the most drug into your blood stream, when you take your dose may affect how much impact the drug has on your blood sugars after meals or when you wake up. For example, the version I take, made by Teva, releases Continue reading >>

Does Metformin Work In The Gut?

Does Metformin Work In The Gut?

The drug metformin is one of the most common drugs prescribed to treat type 2 diabetes. When you’re diagnosed, most physicians prescribe metformin as well as suggesting diet and exercise changes. But not everyone can tolerate metformin. Some people get diarrhea and nausea, sometimes so severe they stop taking the drug. Starting the drug slowly and then increasing the dosage helps. Taking metformin with meals helps. But sometimes that’s not enough and you decide to try something else. Metformin should also not be used if you have impaired kidney function, because the kidney is where the drug is removed, and if your kidneys are impaired, the metformin concentrations might rise too high and cause a serious, sometimes life-threatening, complication called lactic acidosis. Now a group of researchers have found that they can give metformin in a form that has the same benefits but doesn’t have the same side effects. What they do is coat the metformin with a covering that only dissolves in the lower intestine. This approach is like that of enteric aspirin, which doesn’t dissolve in the stomach and hence doesn’t trigger stomach bleeding, a common side effect of aspirin. With this form of metformin, which they call metformin DR for “delayed release,” the drug levels in the blood are about half as low as those of regular metformin, but the blood-glucose-lowering effects are the same. What is interesting about this research is that it suggests that the primary site of action of metformin is in the gut, and not in the liver as has been claimed for some years. Researchers have said that metformin keeps the liver from producing and releasing a lot of glucose, through stimulating a molecule called AMPK. But the metformin worked even when researchers knocked out the AMPK, Continue reading >>

How Does Metformin Work?

How Does Metformin Work?

What is Metformin? It is an oral diabetes drug that is used with proper exercise and diet program to help people control their blood sugar levels. Metformin is the brand name of glucophage which is created by Bristol-Myers Squibb Company. Glucophage is normally prescribed by a doctor when diet and exercise were not successful in lowering your blood sugar levels. Metformin is used to treat people who have type 2 diabetes. Type 2 diabetes refers to a medical condition where your body cannot make enough amount of insulin or use it properly. Insulin is a natural hormone produced by beta cells in the pancreas. This is a naturally occurring hormone that is used to transport glucose to the body tissue where it is used for energy. Without insulin, glucose cannot enter the body cells for energy, hence they stay in the bloodstream. Too much glucose in the bloodstream is dangerous because it can lead to serious health complications if left untreated. When you take this medicine, it lowers your blood glucose levels by improving how your body uses insulin. How does Metformin work? It works by reducing the amount of glucose that is released by your liver into the bloodstream. Also, this medication works by improving how your body responds to insulin, and reducing the amount of glucose that is absorbed by the intestines. As a result, it helps to reduce high blood sugar in people with type 2 diabetes. How long does it take for this medication to work? For you to feel the full effect of metformin, it will take you 4 to 5 days depending on your dose. How fast does the drug work? When you start taking this medication you will see some effects within 48 hours. However, this depends on your dosage and number of times you are taking this medication. Dosing Metformin comes in tablet form whic Continue reading >>

New Information On How Metformin Works

New Information On How Metformin Works

Not only has new research told us how metformin really works, but a new biomarker was found that can determine the optimal dose of metformin that should be used to get the best results for each patient. Research from the Johns Hopkins Children’s Center reveals that the drug most commonly used in Type 2 diabetics who don’t need insulin works on a much more basic level than once thought, treating persistently elevated blood sugar — the hallmark of Type 2 diabetes — by regulating the genes that control its production. investigators say they have zeroed in on a specific segment of a protein called CBP made by the genetic switches involved in overproduction of glucose by the liver that could present new targets for drug therapy of the disease. In healthy people, the liver produces glucose during fasting to maintain normal levels of cell energy production. After people eat, the pancreas releases insulin, the hormone responsible for glucose absorption. Once insulin is released, the liver should turn down or turn off its glucose production, but in people with Type 2 diabetes, the liver fails to sense insulin and continues to make glucose. The condition, known as insulin resistance, is caused by a glitch in the communication between liver and pancreas. Metformin, introduced as frontline therapy for uncomplicated Type 2 diabetes in the 1950s, up until now was believed to work by making the liver more sensitive to insulin. The Hopkins study shows, however, that metformin bypasses the stumbling block in communication and works directly in the liver cells. Senior investigator, Fred Wondisford, M.D., who heads the metabolism division at Hopkins Children’s, tells us that, "Rather than an interpreter of insulin-liver communication, metformin takes over as the messenger itself Continue reading >>

A Comprehensive Guide To Metformin

A Comprehensive Guide To Metformin

Metformin is the top of the line medication option for Pre-Diabetes and Type 2 Diabetes. If you must start taking medication for your newly diagnosed condition, it is then likely that your healthcare provider will prescribe this medication. Taking care of beta cells is an important thing. If you help to shield them from demise, they will keep your blood sugar down. This medication is important for your beta cell safety if you have Type 2 Diabetes. Not only does Metformin lower blood sugar and decrease resistance of insulin at the cellular level, it improves cell functioning, lipids, and how fat is distributed in our bodies. Increasing evidence in research points to Metformin’s effects on decreasing the replication of cancer cells, and providing a protective action for the neurological system. Let’s find out why Lori didn’t want to take Metformin. After learning about the benefits of going on Metformin, she changed her mind. Lori’s Story Lori came in worrying. Her doctor had placed her on Metformin, but she didn’t want to get the prescription filled. “I don’t want to go on diabetes medicine,” said Lori. “If I go on pills, next it will be shots. I don’t want to end up like my dad who took four shots a day.” “The doctor wants you on Metformin now to protect cells in your pancreas, so they can make more insulin. With diet and exercise, at your age, you can reverse the diagnosis. Would you like to talk about how we can work together to accomplish that?” “Reverse?” she asked. “What do you mean reverse? Will I not have Type 2 Diabetes anymore?” “You will always have it, but if you want to put it in remission, you are certainly young enough to do so. Your doctor wants to protect your beta cells in the pancreas. If you take the new medication, Continue reading >>

Metformin, Weight Loss & Pcos – Does It Actually Work?

Metformin, Weight Loss & Pcos – Does It Actually Work?

Did you know that one of the main reasons you can't lose weight with PCOS is because of your hormones? It's true, and that's why many women (and physicians) turn to using Metformin to try and help with weight loss. But just because it works for some people doesn't mean it will necessarily work for YOU. Find out why metformin helps with weight loss, but more important what works better and how to finally lose weight if you have PCOS. ​ Insulin & PCOS: Why It's so Important One of the most common medications prescribed for PCOS is metformin. But, PCOS is a hormonal condition which results in weight gain, hair growth on the face, infertility, acne and estrogen/progesterone imbalances. So why is metformin, a medication used to lower blood sugar and treat insulin resistance, used to treat estrogen/progesterone imbalances in women? The logic is quite simple: Most of the symptoms of PCOS (all those listed above) stem from insulin resistanc e! In fact many physicians recommend that ALL women with PCOS should be treated for insulin resistance regardless of what their fasting insulin and fasting blood sugar levels are. This means that the root cause of PCOS (at least the majority of it) is insulin resistance, and this is why metformin is so commonly used to treat. Insulin resistance causes a block of glucose uptake in your skeletal muscles which results in a lower metabolism (and weight gain), insulin also directly acts on your ovaries and adrenals increasing androgens like testosterone and DHEA. It's also the action of insulin on your pituitary that results in increased LH production which over stimulates your ovaries resulting in the characteristic "cysts" of PCOS. ​ High levels of DHEA and testosterone lead to acne and hair growth (hirsutism). ​ But one simple question r Continue reading >>

Metformin: Improving Insulin Sensitivity

Metformin: Improving Insulin Sensitivity

Metformin is the only medication in the biguanides category of blood glucose-lowering drugs approved by the U.S. Food and Drug Administration (FDA). Metformin has been available in the United States since the mid-1990s, when it received FDA approval. You may also know it by its brand name when it was under patent, Glucophage. Metformin is now widely available as a relatively inexpensive generic medication. Metformin’s main action is to decrease the overproduction of glucose by the liver, a common problem in prediabetes and type 2 diabetes. The action of metformin helps lower blood sugar levels particularly during the night to keep fasting glucose levels under control, but it also helps control blood glucose throughout the day. Metformin also increases the uptake of glucose by your muscles. Overall, metformin decreases insulin resistance and improves insulin sensitivity, thereby helping the insulin your body still makes work more effectively. People with prediabetes and in the early years of type 2 diabetes often continue to make some insulin, just not enough to control blood sugar levels alone. Metformin is not formally approved for use in prediabetes, and any use to treat prediabetes is considered off-label by providers. Since its approval, metformin has become the most commonly recommended blood glucose-lowering medication to treat type 2 diabetes. In recent years it has significantly replaced sulfonylureas, such as glipizide and glyburide. Today both the American Diabetes Association (ADA), the European Association for the Study of Diabetes (EASD), and the American Association of Clinical Endocrinologists (AACE) generally recommend that people with type 2 diabetes start taking metformin when they are diagnosed to help treat insulin resistance and maximize insulin s Continue reading >>

How Long Does Metformin Take To Work

How Long Does Metformin Take To Work

Registration is fast, simple and absolutely free so please,join our community todayto contribute and support the site. This topic is now archived and is closed to further replies. I am newly diagnosed and am on Metformin 250 mg in morning and 250 at night. Can you tell me how long this take to work. My glucose readings were very high last week...25 average and now down to 17 average. I believe about 5 is normal. I am on a low carb diet and exercising daily. Hi Ranelda, welcome to DF. Metformin is one of the oldest T2 drug and it can take weeks to get its full effect. Once your glucose stabilize with your new diet routing, you doctor will then work with you to determine if you need to increase the dosage. The maximum one take is 2550mg per day. I am newly diagnosed and am on Metformin 250 mg in morning and 250 at night. Can you tell me how long this take to work. My glucose readings were very high last week...25 average and now down to 17 average. I believe about 5 is normal. I am on a low carb diet and exercising daily. Yes, those numbers are very high, and that dose of Metformin is very low, even after it kicks in. In the meantime, I suggest trying to lower those numbers by yourself, through diet and exercise. Cut the carbohydrates out of your diet and do some moderate intensity exercising. I think I noticed mine working about 15-20 days. My numbers dropped a lot and have stayed steady since. I take 1000 twice a day though It can take up to a month to work. Also you are taking a very small amount and may need to increase the dosage. I had to raise mine to 2550 before I saw lower bgs in the morning. I've read that Metformin usually takes about 3 weeks to set in, though that may vary from individual to individual, just like it's side effects. As far as dosage is concern Continue reading >>

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