Metformin is a medicine used to treat type 2 diabetes and sometimes polycystic ovary syndrome (PCOS). Type 2 diabetes is an illness where the body doesn't make enough insulin, or the insulin that it makes doesn't work properly. This can cause high blood sugar levels (hyperglycemia). PCOS is a condition that affects how the ovaries work. Metformin lowers your blood sugar levels by improving the way your body handles insulin. It's usually prescribed for diabetes when diet and exercise alone have not been enough to control your blood sugar levels. For women with PCOS, metformin stimulates ovulation even if they don't have diabetes. It does this by lowering insulin and blood sugar levels. Metformin is available on prescription as tablets and as a liquid that you drink. Key facts Metformin works by reducing the amount of sugar your liver releases into your blood. It also makes your body respond better to insulin. Insulin is the hormone that controls the level of sugar in your blood. It's best to take metformin with a meal to reduce the side effects. The most common side effects are feeling sick, vomiting, diarrhoea, stomach ache and going off your food. Metformin does not cause weight gain (unlike some other diabetes medicines). Metformin may also be called by the brand names Bolamyn, Diagemet, Glucient, Glucophage, and Metabet. Who can and can't take metformin Metformin can be taken by adults. It can also be taken by children from 10 years of age on the advice of a doctor. Metformin isn't suitable for some people. Tell your doctor before starting the medicine if you: have had an allergic reaction to metformin or other medicines in the past have uncontrolled diabetes have liver or kidney problems have a severe infection are being treated for heart failure or you have recentl Continue reading >>
Role Of Metformin In The Management Of Polycystic Ovary Syndrome
Go to: Background Polycystic ovary syndrome (PCOS) is the most common endocrinological disorder affecting 4–12% of women [Diamanti-Kandarakis et al. 1999; Farah et al. 1999; Knochenhauer et al. 1998]. It has also been the most controversial medical condition and every aspect has received a lot of attention from the nomenclature to the management. Several descriptions of similar conditions took place in the 20th century and it was named Stein—Leventhal Syndrome in 1935 after the authors who described polycystic ovarian morphology in patients suffering from hirsutism, amenorrhoea and infertility [Leventhal, 1958; Stein and Leventhal, 1935]. PCOS was also called polycystic ‘ovarian’ syndrome implying that the primary pathology lies in or triggered by the ovary. Others have called it polycystic ovary disease (PCOD), which is the least used term for obvious reasons. Currently, PCOS refers to a disorder with a combination of reproductive and metabolic characteristics. This has evolved over time with controversy over the definition culminating in the latest consensus [ESHRE/ASRM, 2004] which instead of solving the issue created more controversy [Azziz et al. 2006]. In the European Society of Human Reproduction and Embryology/American Society of Reproductive Medicine (ESHRE/ASRM) consensus, at least two of the following features are needed to make the diagnosis; oligo/anovulation, hyperandrogenism, and polycystic features on ultrasound scan [ESHRE/ASRM, 2004]. The Androgen Excess Society, however, recommended that androgen excess should remain a constant feature of PCOS irrespective of the ovulatory status and morphological features of the ovaries [Azziz et al. 2006]. For almost three decades, PCOS has been regarded as a life course disease which besides its reproductiv Continue reading >>
How Long Should A Person Take Metformin?
Home Q & A Questions How long should a person take... As long as its needed to control your blood sugar. Still looking for answers? Try searching for what you seek or ask your own question . Diabetes, Type 2 - Do I really need to reduce my meds. doses ? I am a diabetic type 2 , taking? I'm type2 diabetic,taking metformin 500 mg daily,can I take alka zeltzer cold ? The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices. Subscribe to receive email notifications whenever new articles are published. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated Feb 28th, 2018), Cerner Multum (updated Mar 1st, 2018), Wolters Kluwer (updated Mar 1st, 2018) and others. To view content sources and attributions, please refer to our editorial policy . Continue reading >>
Metformin For Diabetes
Take metformin just after a meal or with a snack. The most common side-effects are feeling sick, diarrhoea and tummy (abdominal) pain. These symptoms usually pass after the first few days of treatment. Keep your regular appointments with your doctor and clinics. This is so your progress can be checked. About metformin Type of medicine A biguanide antidiabetic medicine Used for Type 2 diabetes mellitus Also called Bolamyn®; Diagemet®; Glucient®; Glucophage®; Metabet®; Sukkarto® Available as Tablets and modified-release tablets; oral liquid medicine; sachets of powder Insulin is a hormone which is made naturally in your body, in the pancreas. It helps to control the levels of sugar (glucose) in your blood. If your body does not make enough insulin, or if it does not use the insulin it makes effectively, this results in the condition called sugar diabetes (diabetes mellitus). People with diabetes need treatment to control the amount of sugar in their blood. This is because good control of blood sugar levels reduces the risk of complications later on. Some people can control the sugar in their blood by making changes to the food they eat but, for other people, medicines like metformin are given alongside the changes in diet. Metformin allows the body to make better use of the lower amount of insulin which occurs in the kind of diabetes known as type 2 diabetes. Metformin can be given on its own, or alongside insulin or another antidiabetic medicine. There are a number of tablets available which contain metformin in combination with one of these other antidiabetic medicines (brands include Jentadueto®, Competact®, Komboglyze®, Janumet®, and Eucreas®). Taking a combination tablet like these can help to reduce the total number of tablets that need to be taken each d Continue reading >>
Drug information provided by: Micromedex This medicine usually comes with a patient information insert. Read the information carefully and make sure you understand it before taking this medicine. If you have any questions, ask your doctor. Carefully follow the special meal plan your doctor gave you. This is a very important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed. Metformin should be taken with meals to help reduce stomach or bowel side effects that may occur during the first few weeks of treatment. Swallow the extended-release tablet whole with a full glass of water. Do not crush, break, or chew it. While taking the extended-release tablet, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about. Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid. Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way. You may notice improvement in your blood glucose control in 1 to 2 weeks, but the full effect of blood glucose control may take up to 2 to 3 months. Ask your doctor if you have any questions about this. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the Continue reading >>
Metformin may rarely cause a serious, life-threatening condition called lactic acidosis. Tell your doctor if you have kidney disease. Your doctor will probably tell you not to take metformin. Also, tell your doctor if you are over 65 years old and if you have ever had a heart attack; stroke; diabetic ketoacidosis (blood sugar that is high enough to cause severe symptoms and requires emergency medical treatment); a coma; or heart or liver disease. Taking certain other medications with metformin may increase the risk of lactic acidosis. Tell your doctor if you are taking acetazolamide (Diamox), dichlorphenamide (Keveyis), methazolamide, topiramate (Topamax, in Qsymia), or zonisamide (Zonegran). Tell your doctor if you have recently had any of the following conditions, or if you develop them during treatment: serious infection; severe diarrhea, vomiting, or fever; or if you drink much less fluid than usual for any reason. You may have to stop taking metformin until you recover. If you are having surgery, including dental surgery, or any major medical procedure, tell the doctor that you are taking metformin. Also, tell your doctor if you plan to have any x-ray procedure in which dye is injected, especially if you drink or have ever drunk large amounts of alcohol or have or have had liver disease or heart failure. You may need to stop taking metformin before the procedure and wait 48 hours to restart treatment. Your doctor will tell you exactly when you should stop taking metformin and when you should start taking it again. If you experience any of the following symptoms, stop taking metformin and call your doctor immediately: extreme tiredness, weakness, or discomfort; nausea; vomiting; stomach pain; decreased appetite; deep and rapid breathing or shortness of breath; dizzi Continue reading >>
Stopping Metformin: When Is It Ok?
The most common medication worldwide for treating diabetes is metformin (Glumetza, Riomet, Glucophage, Fortamet). It can help control high blood sugar in people with type 2 diabetes. It’s available in tablet form or a clear liquid you take by mouth before meals. Metformin doesn’t treat the underlying cause of diabetes. It treats the symptoms of diabetes by lowering blood sugar. It also increases the use of glucose in peripheral muscles and the liver. Metformin also helps with other things in addition to improving blood sugar. These include: lowering lipids, resulting in a decrease in blood triglyceride levels decreasing “bad” cholesterol, or low-density lipoprotein (LDL) increasing “good” cholesterol, or high-density lipoprotein (HDL) If you’re taking metformin for the treatment of type 2 diabetes, it may be possible to stop. Instead, you may be able to manage your condition by making certain lifestyle changes, like losing weight and getting more exercise. Read on to learn more about metformin and whether or not it’s possible to stop taking it. However, before you stop taking metformin consult your doctor to ensure this is the right step to take in managing your diabetes. Before you start taking metformin, your doctor will want to discuss your medical history. You won’t be able to take this medication if you have a history of any of the following: alcohol abuse liver disease kidney issues certain heart problems If you are currently taking metformin, you may have encountered some side effects. If you’ve just started treatment with this drug, it’s important to know some of the side effects you may encounter. Most common side effects The most common side effects are digestive issues and may include: diarrhea vomiting nausea heartburn abdominal cramps Continue reading >>
How Long Does It Take For Metformin To Work?
Metformin, also known as Glucophage, is a medication that is used to regulate the levels of glucose (sugar) in the blood. Metformin accomplishes its task through three methods. First, it causes the liver to produce less glucose. Second, metformin helps your stomach to absorb less glucose from the food that you eat. Finally, metformin improves the efficiency of the insulin that the body produces, which reduces the amount of glucose that is in your blood. Metformin is often prescribed for people with Type II diabetes. How long it takes Metformin to work depends on the reason that a woman is taking metformin. If a woman is taking metformin to regulate her blood sugar, metformin typically will work within a few days or a few weeks at the most. For the woman with polycystic ovarian syndrome (PCOS) metformin can help to reduce the amount of insulin in the body. Once the insulin levels are under control, many women will then experience improved ovulation. If metformin is going to work for a woman who has experienced fertility problems because of her polycystic ovarian syndrome, it will typically help within three to six months. Unlike most fertility treatments, metformin does not cause a risk of having a multiple or twin pregnancy. If metformin alone does not help a woman with PCOS who is trying to conceive, a fertility doctor may prescribe Clomid, as well. If metformin is prescribed for a woman with PCOS to help restore a regular, normal menstrual cycle, metformin can work within 4 to 8 weeks. In addition, the stabilized levels of insulin may affect the other hormones in a woman’s body, and reduce other symptoms of PCOS. Some women, either with diabetes or PCOS, use metformin as a tool for weight loss. If this is the case, weight loss can occur somewhere between 1 and 5 wee Continue reading >>
Timing Your Metformin Dose
The biggest problem many people have with Metformin is that it causes such misery when it hits their stomachs that they can't keep taking it even though they know it is the safest and most effective of all the oral diabetes drugs. In many cases all that is needed is some patience. After a rocky first few days many people's bodies calm down and metformin becomes quite tolerable. If you are taking the regular form of Metformin with meals and still having serious stomach issues after a week of taking metformin, ask your doctor to prescribe the extended release form--metformin ER or Glucophage XR. The extended release form is much gentler in its action. If that still doesn't solve your problem, there is one last strategy that quite a few of us have found helpful. It is to take your metformin later in the day, after you have eaten a meal or two. My experience with metformin--and this has been confirmed by other people--is that it can irritate an empty stomach, but if you take it when the stomach contains food it will behave. There are some drugs where it matters greatly what time of day you take the drug. Metformin in its extended release form is not one of them. As the name suggests, the ER version of the pill slowly releases the drug into your body over a period that, from my observations, appears to last 8 to 12 hours. Though it is supposed to release over a full 24 hours, this does not appear to be the case, at least not with the generic forms my insurer will pay for. Because there seems to be a span of hours when these extended release forms of metformin release the most drug into your blood stream, when you take your dose may affect how much impact the drug has on your blood sugars after meals or when you wake up. For example, the version I take, made by Teva, releases Continue reading >>
- Advice to walk after meals is more effective for lowering postprandial glycaemia in type 2 diabetes mellitus than advice that does not specify timing: a randomised crossover study
- Timing of Delivery in Gestational Diabetes Mellitus: Need for Person-Centered, Shared Decision-Making
- Timing Luck And A Bit Of Diabetes
A Comprehensive Guide To Metformin
Metformin is the top of the line medication option for Pre-Diabetes and Type 2 Diabetes. If you must start taking medication for your newly diagnosed condition, it is then likely that your healthcare provider will prescribe this medication. Taking care of beta cells is an important thing. If you help to shield them from demise, they will keep your blood sugar down. This medication is important for your beta cell safety if you have Type 2 Diabetes. Not only does Metformin lower blood sugar and decrease resistance of insulin at the cellular level, it improves cell functioning, lipids, and how fat is distributed in our bodies. Increasing evidence in research points to Metformin’s effects on decreasing the replication of cancer cells, and providing a protective action for the neurological system. Let’s find out why Lori didn’t want to take Metformin. After learning about the benefits of going on Metformin, she changed her mind. Lori’s Story Lori came in worrying. Her doctor had placed her on Metformin, but she didn’t want to get the prescription filled. “I don’t want to go on diabetes medicine,” said Lori. “If I go on pills, next it will be shots. I don’t want to end up like my dad who took four shots a day.” “The doctor wants you on Metformin now to protect cells in your pancreas, so they can make more insulin. With diet and exercise, at your age, you can reverse the diagnosis. Would you like to talk about how we can work together to accomplish that?” “Reverse?” she asked. “What do you mean reverse? Will I not have Type 2 Diabetes anymore?” “You will always have it, but if you want to put it in remission, you are certainly young enough to do so. Your doctor wants to protect your beta cells in the pancreas. If you take the new medication, Continue reading >>
How Long Does It Take To Get Pregnant With Metformin For Pcos Woman?
Metformin is a multiplier. It can treat insulin resistance, if you have it, and help you lose weight. (In my case, mostly by making me too nauseous to eat.) Both things can make you slightly more likely to ovulate. It also decreases your risk of developing diabetes in the future. However, metformin alone isn't a fertility treatment. It is usually combined with other drugs, like Clomid, Femera, or injectable medications, to stimulate ovulation. Your doctors may try you on metformin alone for a short period of time, usually 3 months or less. If you don't become pregnant after that, they'll usually start the other medications. The bad news is that no one can predict exactly how long it will take you to get pregnant. This is one of the worst parts of infertility. I have been through it. The intense frustration of not knowing how long I would have to keep trying drove me nuts. The good news is that PCOS is very treatable. If your doctors are willing to start with just metformin, then your case is probably also fairly mild. For younger women with PCOS, success rates are very high. Hang in there! And yes, metformin is terrible. You aren't imagining how bad you feel. The side effects will probably let up shortly. If you feel really exhausted, ask your doctor about adding a B12 supplement to your diet. Metformin causes a B12 deficiency in about 30% of patients, which can make you feel tired. Continue reading >>
What Are The Long-term Effects Of Metformin?
Metformin is a prescription drug that is used to help control blood glucose levels in individuals with type 2 diabetes mellitus. It is commonly sold under the brand names Glucophage and Fortamet and is available in regular and slow-release tablets. Metformin works by acting on the liver and intestines to decrease secretion and absorption of glucose into the blood. It also increases the insulin sensitivity of muscles and tissues of the body so that they take up glucose more readily. MayoClinic.com underlines that as with any medication, metformin can cause unwanted side effects that may be common or more serious. Video of the Day Patients taking metformin, particularly women may experience general malaise, fatigue, and occasional achiness. Malaise may be caused by other effects of metformin on the liver, kidneys, stomach and intestines, as noted by Drugs.com. Vitamin B12 Malabsorption Vitamin B12 malabsorption may also occur in some patients on metformin treatment. MayoClinic.com explains that a chemical in the stomach called intrinsic factor is required for the body to absorb vitamin B12. Metformin can interfere with this chemical, causing decreased absorption of the vitamin. Over the long term, a vitamin B12 deficiency can cause significant health risks as this essential vitamin is important for synthesis of DNA, red blood cell production and other biochemical functions in the body. Decreased vitamin B12 in the blood can lead to megoblastic anemia in which the bone marrow cannot adequately manufacture red blood cells. Though this type of anemia is not common, it can occur from long-term use of metformin, causing decreased vitamin B12 levels. Long-term metformin use can cause liver or kidney problems in some individuals, according to MayoClinic.com, because the medicati Continue reading >>
**Metformin controls the insulin resistance of people who have type 2 diabetes so well that, if possible, all of us should be taking it. That’s what Roderic Crist, M.D., told me at the annual convention of the American Society of Bariatric Physicians in Denver this weekend. Dr. Crist specializes in family medicine in Cape Girardeau, Missouri. "Not everybody can take every drug," he added, when I followed up our conversation by calling him at his office after he returned home. "But most of the time people can take metformin if they take it carefully." Doctors increasingly prescribe it not only for type 2 diabetes but also for insulin resistance, polycystic ovary syndrome, and non-alcoholic fatty liver disease. Roughly one-third of Dr. Crist’s patients have diabetes. Well over half, if not two-thirds of the people he sees are insulin resistant. "I treat insulin resistance with that drug even if they aren’t fully diabetic." he says. "If they have high triglyceride levels and low HDL levels, particularly if they are centrally obese, they should probably be on metformin. It helps slow the progression of the disease from one thing to the next." But he goes further. He prescribes metformin to almost all of his patients who have type 2 diabetes – no matter how low their A1C level is. And he tells his patients that their levels should be 5.0 or less – not the American Diabetes Association’s less stringent recommendation of 7.0 or less. "If their A1C is at 5, their diabetes is in complete remission. So I have that as a goal." And he still prescribes metformin to them after they reach that goal. "The two important issues are that it will prevent progression and it should be used in the earliest phases of insulin resistance. We vastly underutilize metformin." But he has Continue reading >>
Metformin For The Treatment Of Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a disorder of body metabolism that affects 5-10% of women and can cause infrequent periods, weight gain, acne, unwanted hair growth and infertility. PCOS should not be confused with the incidental finding of polycystic ovaries on an ultrasound scan which occur in about 20% of the female population and usually do not cause any symptoms. The cause of PCOS is not fully understood but is thought to have a genetic component. The small cysts seen in the ovaries do not cause PCOS but are the result of the underlying disturbance of metabolism. Most women with PCOS do not have every symptom and the treatment that a doctor recommends is usually chosen to treat the symptoms that bother the woman. In recent years there has been a lot of interest in the use of Metformin to treat the symptoms of PCOS. This information sheet aims to answer many of the questions that women have about this treatment. What is Metformin? Metformin is a medicine that is taken by mouth. It is from a family of drugs known as biguanides and was developed to treat type 2 (late onset) diabetes. Why is it used to treat PCOS? There are a number of similarities between PCOS and adult-onset diabetes. In both conditions, people have a resistance to the effects of insulin with resulting high levels of insulin in their blood stream. These high insulin levels cause an increased production of androgens (male-type hormones that can cause acne and unwanted hair growth) in the ovaries and adrenal glands. This in turn affects the pituitary hormones (LH and FSH) that normally stimulate the ovaries to produce eggs. The result is often irregular infertile periods. Metformin increases the effectiveness of insulin, resulting in a lowering of blood insulin levels which in turn lowers the androg Continue reading >>
- Type 1 Diabetes and Polycystic Ovary Syndrome: Systematic Review and Meta-analysis
- Polycystic Ovary Syndrome and Diabetes
- Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE)
Metformin Users-how Long Have You Been Taking It?
Metformin users-how long have you been taking it? Registration is fast, simple and absolutely free so please,join our community todayto contribute and support the site. This topic is now archived and is closed to further replies. Metformin users-how long have you been taking it? Thank you for help with this survey to help me determine how many years I can safely expect to be on Metformin. 2. If over a year, have you experienced any diabetic complications? ie kidney, liver, heart or any other organ 3. Other then side effects of having to use bathroom, and weight loss, are there any other side effects you've experienced? 4. I would also love to hear from those who have been on it over two years and how they are doing. Has it lost its effect? Are you having to diet and exercise more to get the same results. Thanks so much and if this would be better off in a different thread, please accept my humble apologies and move it. I was on metformin the first year of my diagnosis. I asked my doctor to start Byetta after reading a Mendosa article that suggested it may help slow the T2 progress by regenerating islet cells. When I started on Byetta, I went off the metformin, as I found myself going too low after meals. I had no problems tolerating metformin. I was started on 500 mg twice daily and stayed on this dose with good results. I did notice that if I ate "greasy" foods, i'd have diarrhea. I did lose weight, but at that time I also started execising and eating lower carb. I have a coworker who has been on metformin for 10 years now with no problems, though she has had to add other meds to keep BS stable (she is not a very compliant diabetic). Its a great medication for insulin resistance. If you need it and can tolerate it, don't be afraid to take it. Also, many have been able Continue reading >>