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How Does Januvia Work For Diabetes?

How Januvia Helps Control Blood Sugar Levels In Type 2 Diabetespatients

How Januvia Helps Control Blood Sugar Levels In Type 2 Diabetespatients

How Januvia Helps Control Blood Sugar Levels In Type 2 DiabetesPatients Diabetes is a disease that occurs when the levels of insulin in a persons body are not normal. There are two types of diabetes diabetes type 1 and diabetes type 2. Type 2 diabetes patients, (those that are not on insulin), can be controlled by the drug Januvia, but this drug cannot be used for type 1 diabetes patients. Januvia is also called Sitagliptin, and it is an oral form of medication that helps to control the levels of insulin in the body, especially after eating, in people that have type 2 diabetes. In some cases, it is used in combination with other medications. It is important that people taking Januvia also keep up with their exercise routines, watch their weight, practice a diet that is good for diabetics, and they should continue to take their other medications. Januvia should only be taken under a doctors care. The drug Januvia may be taken with meals or not. It all depends on what the doctor prescribes for the person. Anyone who is taking the drug should follow the doctors instructions completely. It is an oral form of medication that can be taken with or without a meal. For most people, the daily dosage of Januvia is 100 mg. It is important that the doctor know any of the other medications that a person is taking because Januvia may interfere with some of them. In controlled studies, only 5 % of the people taking it had adverse side effects from taking Januvia. You can buy Januvia online at; www.planetdrugsdirect.com/drugs/januvia Important Things To Remember When Taking Januvia It is important that people do not let their blood sugar levels dip when they are taking Januvia. They should not skip meals because this will cause them to feel tired, they may sweat, have tremors, feel hun Continue reading >>

Januvia (sitagliptin)

Januvia (sitagliptin)

What is it used for? Januvia can be used on its own to improve blood sugar control in people whose blood sugar is not controlled by changes to their diet and exercise alone and who can't take metformin. Januvia is also used for people with type 2 diabetes whose blood sugar is not sufficiently controlled by other antidiabetic medicines. It can be added to treatment with metformin, a sulphonylurea (for example gliclazide) or another type of antidiabetic medicine known as a thiazolidinedione (for example pioglitazone or rosiglitazone). It can also be used for people who are using insulin. How does it work? Januvia tablets contain the active ingredient sitagliptin, which is a type of medicine called a dipeptidyl peptidase 4 (DPP-4) inhibitor. It is used to treat people with type 2 or non-insulin dependent diabetes (NIDDM). Sitagliptin works by increasing the amount of two incretin hormones found in the body, called glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). These hormones are normally produced naturally by the body in response to food intake. Their function is to help control blood sugar (glucose) levels. GLP-1 and GIP have four main actions that help to control blood glucose. Firstly, they stimulate the pancreas to produce insulin in response to increasing levels of glucose in the blood. (Insulin is the main hormone responsible for controlling sugar levels in the blood. It causes cells in the body to remove sugar from the blood.) GLP-1 also reduces the production of glucagon. (Glucagon is a hormone that normally increases glucose production by the liver.) GLP-1 and GIP also reduce the rate at which food passes from the stomach into the intestines, which slows down the absorption of glucose from the gut into the bloodstream. Finally, Continue reading >>

How Does Januvia Work In Your Body?

How Does Januvia Work In Your Body?

JANUVIA (jah-NEW-vee-ah) is a once-daily prescription pill that, along with diet and exercise, helps lower blood sugar levels in adults with type 2 diabetes. JANUVIA should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUVIA. Serious side effects can happen in people who take JANUVIA, including pancreatitis, which may be severe and lead to death. Before you start taking JANUVIA, tell your doctor if you've ever had pancreatitis. Stop taking JANUVIA and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis. Before you start taking JANUVIA, tell your doctor if you have ever had heart failure (your heart does not pump blood well enough) or have problems with your kidneys. Contact your doctor right away if you have increasing shortness of breath or trouble breathing (especially when you lie down); swelling or fluid retention (especially in the feet, ankles, or legs); an unusually fast increase in weight; or unusual tiredness. These may be symptoms of heart failure. Do not take JANUVIA if you are allergic to any of its ingredients, including sitagliptin. Symptoms of serious allergic reactions to JANUVIA, including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing, can occur. If you have any symptoms of a serious allergic reaction, stop taking JANUVIA and call your doctor right away. Kidney problems, somet Continue reading >>

Sitagliptin For Diabetes Januvia

Sitagliptin For Diabetes Januvia

Take sitagliptin tablets once a day. Remember to follow any advice you have been given about your diet. The most common side-effects are feeling sick (nausea), headache, and nose or throat infections. About sitagliptin Type of medicine An antidiabetic medicine Used for Adults with type 2 diabetes mellitus Also called Januvia®; Janumet® (a combination tablet containing sitagliptin with metformin) Available as Tablets Insulin is a hormone which is made naturally in your body, in the pancreas. It helps to control the levels of sugar in your blood. If your body does not make enough insulin, or if it does not use the insulin it makes effectively, this results in the condition called sugar diabetes (diabetes mellitus). People with diabetes need treatment to control the amount of sugar (glucose) in their blood. This is because good control of blood glucose levels reduces the risk of complications later on. Some people can control the sugar in their blood by making changes to the food they eat but, for other people, medicines like sitagliptin are given alongside the changes in diet. Sitagliptin works in part by increasing the amount of insulin produced by your body. It also reduces the amount of a substance called glucagon being produced by your pancreas. Glucagon causes your liver to produce more sugar, so by reducing the amount of glucagon in your body, this also helps to reduce the levels of glucose in your blood. Before taking sitagliptin Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking sitagliptin it is important that your doctor knows: If you are pregnant, trying for a baby or breast-feeding. If you have any problems with the way your kidneys w Continue reading >>

(sitagliptin And Metformin Hcl) Tablets Or

(sitagliptin And Metformin Hcl) Tablets Or

JANUMET tablets contain 2 prescription medicines: sitagliptin (JANUVIA®) and metformin. Once-daily prescription JANUMET XR tablets contain sitagliptin (the medicine in JANUVIA®) and extended-release metformin. JANUMET or JANUMET XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. JANUMET or JANUMET XR should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUMET or JANUMET XR. Selected Risk Information About JANUMET and JANUMET XR Metformin, one of the medicines in JANUMET and JANUMET XR, can cause a rare but serious side effect called lactic acidosis (a buildup of lactic acid in the blood), which can cause death. Lactic acidosis is a medical emergency that must be treated in a hospital. Call your doctor right away if you get any of the following symptoms, which could be signs of lactic acidosis: feel cold in your hands or feet; feel dizzy or lightheaded; have a slow or irregular heartbeat; feel very weak or tired; have unusual (not normal) muscle pain; have trouble breathing; feel sleepy or drowsy; have stomach pains, nausea, or vomiting. Most people who have had lactic acidosis with metformin have other things that, combined with the metformin, led to the lactic acidosis. Tell your doctor if you have any of the following, because you have a higher chance of getting lactic acidosis with JANUMET or JANUMET XR if you: have severe kidney problems or your kidneys are affected by certain x-ray tests that use injectable dye; have liver problems; drink alcohol very often, or drink a lot of alcohol in short-term “binge” drinkin Continue reading >>

Januvia

Januvia

are allergic to dapagliflozin or any of the ingredients in FARXIGA. Symptoms of a serious allergic reaction may include skin rash, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. If you have any of these symptoms, stop taking FARXIGA and contact your healthcare provider or go to the nearest hospital emergency room right away have severe kidney problems or are on dialysis. Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with FARXIGA Dehydration (the loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at a higher risk of dehydration if you have low blood pressure; take medicines to lower your blood pressure, including water pills (diuretics); are 65 years of age or older; are on a low salt diet, or have kidney problems Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with FARXIGA. Ketoacidosis is a serious condition which may require hospitalization and may lead to death. Symptoms may include nausea, tiredness, vomiting, trouble breathing, and abdominal pain. If you get any of these symptoms, stop taking FARXIGA and call your healthcare provider right away. If possible, check for ketones in your urine or blood, even if your blood sugar is less than 250 mg/dL Kidney problems. Sudden kidney injury occurred in people taking FARXIGA. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or excessive heat exposure Serious urinary tract infections (UTI), some that lead to hospitalization, occu Continue reading >>

Januvia Smackdown

Januvia Smackdown

Get your ringside seats, Folks! A while back I posted about the Merck's new Type 2 oral drug Januvia (What It Doesn't Do), explaining how it apparently trumps competitors in terms of patient "tolerability." No other post has ever generated such ongoing reader energy, both positive and negative. Nearly every day, several new commentors weigh in, duking it out over the relative merits of Januvia. Most everyone seems to agree that Januvia reduces appetite, which is a good thing. But then again, Byetta is known for that effect as well. The key is question whether Januvia fulfills its core function of lowering blood glucose (BG) levels, and lives up to its no-side-effects promise. As of today, the score stands pretty much tied, as such: Total comments = 50 Positive = 10 Negative = 13 Mixed = 16 (liked some aspects of the drug but not others) Neutral = 11 (those asking or responding to questions only) Among the most vocal of the Pro Team: "I take Januvia and have for 6 months. I have no side effects. I have experienced a decrease in appetite. I have had no headaches or respiratory problems. My BG has gone down. It is a great drug." -- Mike "Januvia has been a positive thing for me. My sugar levels dropped from 240+ to 110 +/- 10 after fasting. I have taken 100 mg once per day for a month... I am not as hungry as before usage." -- Jim K. L. "I've been on Januvia for a little over three months and have lost over 15 pounds which I had put on with Actos. I've experienced no side effects, other than I am not hungry all of the time. For me it has been very effective..." -- Bill "I am substantially less hungry then I have felt in years ... and my BG hovers around 100 - 120 between meals/fasting, and 120 - 160 for a few hours after a heavy carb meal. The usual BG spikes of 180 - 200+ Continue reading >>

How Does Januvia Help Patients With Type Ii Diabetes?

How Does Januvia Help Patients With Type Ii Diabetes?

If you are a Type II diabetes patient who has trouble controlling their blood sugar, Januvia is an option worth trying. Instead of insulin and other intravenous options, Januvia is an oral medication you take daily. While you can’t do away with those constant sugar checks, it goes a long way towards regulating your fluctuating blood sugar. How does Januvia work? Januvia is a DPP-4 inhibitor, a class of diabetes medication that works with the (surprise!) DPP-4 protein; this protein helps with the body’s glucose metabolism. With that said, Januvia works in two different ways. First it increases the body’s natural production of insulin to help stabilize your blood sugar. Then it decreases the sugar produced in the liver, helping to create a balance. The way your body uses it depends on your current blood sugar. It works more when your blood sugar is high and less when it is low. While it cannot replace your entire diabetes regimen, it can help lower your need for rescue medications. Is Januvia right for me? First things first, Januvia is only for people with Type II diabetes, so if you have Type I, you are out of luck. Because it helps regulate insulin production, it is only useful for patients whose pancreas can still create it. Also make sure to let your doctor know beforehand if you have or had any of the following conditions: kidney disease sitagliptin allergy pancreatitis high triglycerides gallstones a history of alcoholism diabetic ketoacidosis While it’s important to let your doctor know if you are pregnant or planning on become pregnant, it does not affect your unborn baby. Its effects on breast milk are still unknown though, so also make sure to let your doctor know if you are currently breastfeeding. What are normal side effects for Januvia? When should Continue reading >>

Wait Times: How Long Until Your Med Begins Working

Wait Times: How Long Until Your Med Begins Working

Photography by Mike Watson Images/Thinkstock There are many type 2 medications, and each drug class works in the body in a different way. Here’s a quick guide to help you understand how long each drug will generally take to work: These short-acting oral medications, taken with meals, block the breakdown of complex sugars into simple sugars in the gastrointestinal (GI) tract. “Simple sugars are more easily absorbed and cause the blood sugar to ultimately go up,” Sam Ellis, PharmD, BCPS, CDE, associate professor in the Department of Clinical Pharmacy at the University of Colorado says. These drugs are minimally absorbed into the blood, so a certain blood level concentration is not necessary for them to work. You will see the effect immediately with the first dose. “You take it before a meal, and with that meal you see the effect,” says George Grunberger, MD, FACP, FACE, President of the American Association of Clinical Endocrinologists. While researchers aren’t exactly sure how these oral medications work, it’s likely that the meds block some absorption of glucose in the GI tract. “You’ll see most of the effect in the first week with these drugs,” says Ellis. alogliptin, linagliptin, saxagliptin, sitagliptin These drugs work to block the enzyme responsible for the breakdown of a specific gut hormone that helps the body produce more insulin when blood glucose is high and reduces the amount of glucose produced by the liver. Take a DPP-4 inhibitor (they come in pill form) and it’ll work pretty fast—you’ll see the full effect in about a week. “It’s blocking that enzyme after the first dose a little bit, but by the time you get out to dose five, you’re blocking the majority of that enzyme,” Ellis says. albiglutide, dulaglutide, exenatide, exe Continue reading >>

Sitagliptin

Sitagliptin

Sitagliptin is used along with diet and exercise and sometimes with other medications to lower blood sugar levels in patients with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally). Sitagliptin is in a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by increasing the amounts of certain natural substances that lower blood sugar when it is high. Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes. Sitagliptin comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take sitagliptin at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sitagliptin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Sitagliptin helps to control high blood sugar but does not cure diabetes. Continue to take sitagliptin even if you feel well. Do not stop taking sitagliptin withou Continue reading >>

Januvia

Januvia

How does this medication work? What will it do for me? Sitagliptin belongs to the group of diabetes medications called DPP-4 inhibitors. It works by increasing the amount of incretin released by the intestine. Incretin is a hormone that raises insulin levels when blood sugar is high and decreases the amount of sugar made by the body. Sitagliptin is used alone or in combination with other medications to improve blood sugar levels in adults with type 2 diabetes. This medication should be used as part of an overall diabetes management plan that includes a diet and exercise program. This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here. Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor. Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it. What form(s) does this medication come in? 25 mg Each pink, round, film-coated tablet, with "221" on one side, contains 25 mg sitagliptin. Nonmedicinal ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate (calcium hydrogen phosphate, anhydrous), croscarmellose sodium, magnesium stearate, and sodium stearyl fumarate; film coating: polyvinyl alcohol, polyethylene gl Continue reading >>

How Januvia Works

How Januvia Works

UPDATE (April 2, 2013): Before you take Byetta, Victoza, Onglyza, or Januvia please read about the new research that shows that they, and probably all incretin drugs, cause severely abnormal cell growth in the pancreas and precancerous tumors. You'll find that information HERE. Original Post: This blog has been getting heavy traffic from people searching for information about Januvia, and I'm also getting a lot of mail on the topic. Much of it shows that doctors do not understand the way that this new incretin drug works to lower blood sugar and are therefore prescribing it inappropriately. As a result, a lot of people who are taking Januvia report seeing very high blood sugars. Let's look at why this might be and what it tells them about their true medication needs. The main way that Januvia lowers blood sugar is by raising the level of a substance, GLP-1, which is produced in the gut and has the ability to do several things. 1. GLP-1 stimulates the beta cell to secrete insulin in a manner very similar to that of the sulfonylurea drugs like Amaryl and Glipizide (sulfs). What is different about using Januvia to do this, is that GLP-1 only causes your beta cells to secrete insulin when blood sugar rises to a certain level (for me, it was 120 mg/dl). Thus with GLP-1 stimulation you don't have the problem you have with sulf drugs of insulin being produced all the time, even when there is no glucose coming into the blood stream, and so Januvia does not cause hypos as sulf drugs do. 2. GLP-1 also affects the speed of stomach emptying. This is why larger doses of artificial GLP-1, Byetta, causes vomiting and very slow stomach emptying. The levels of GLP-1 Januvia causes are much lower than those you get with Byetta, so the digestive symptoms are milder, but they are most defi Continue reading >>

Januvia Side Effects Center

Januvia Side Effects Center

Januvia (sitagliptin) is an oral diabetes medicine for people with type 2 diabetes (non-insulin-dependent) diabetes. Januvia is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes. Many people using Januvia do not have serious side effects. Side effects that may occur with Januvia include: headache, joint or muscle pain, nausea, stomach pain, diarrhea, or constipation. Although Januvia by itself usually does not cause low blood sugar (hypoglycemia), low blood sugar may occur if Januvia is prescribed with other anti-diabetic medications. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. Tell your doctor if you have serious side effects of Januvia including pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, fast heart rate), urinating less than usual or not at all, swelling, weight gain, shortness of breath, or severe skin reaction (fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads [especially in the face or upper body] and causes blistering and peeling). The recommended dose of Januvia is 100 mg once daily. Januvia may interact with digoxin, probenecid, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), or beta-blockers. Tell your doctor all prescription and over-the-counter medications you use. During pregnancy Januvia should be used only when prescribed. Pregnancy may cause or worsen diabetes. Your doctor may change your diabetes treatment during pregnancy. It is unknown if this drug passes into breast milk. Cons Continue reading >>

Januvia And Janumet

Januvia And Janumet

Januvia (sitagliptin) is an oral Type 2 diabetes medication manufactured by Merck & Co. The U.S. Food and Drug Administration (FDA) approved the drug in 2006, and it is one of the most popular Type 2 diabetes drugs on the market. In 2007, the FDA approved a variation of Januvia called Janumet, which is a combination of sitagliptin and metformin. Janumet also comes in an extended-release formula called Janumet XR. Januvia and Janumet are known as dipeptidyl peptidase 4 (DPP-4) inhibitors that work by helping the body produce more insulin. Both Januvia and Janumet belong to a class of drugs called dipeptidyl peptidase 4 (DPP-4) inhibitors that work by helping the body produce more insulin. Januvia was the first DPP-4 approved by the FDA and is the top-selling brand in its class. Two million prescriptions were written for Januvia in 2011. Januvia brought in about $6 billion in 2014. Merck stands to benefit from the patent on the drug until 2022. In clinical trials, Januvia proved effective in controlling blood-sugar levels. However, some studies reported rare and serious side effects, including acute pancreatitis, severe joint pain, pancreatic cancer and thyroid cancer. How Do Januvia and Janumet Work? Januvia is designed to work with other Type 2 diabetes medications, like Byetta, to increase their effectiveness. It helps lower blood sugar in two ways. It helps the body increase insulin to stabilize blood sugar and decrease sugars that are made in the liver. It is a part of the class of diabetes medications called DPP-4 inhibitors. DPP-4 is a protein made by the body that plays a role in glucose metabolism. The process works like this: After a person eats and blood sugar rises, intestinal cells release hormones called incretin hormones. Incretin stimulates pancreatic cell Continue reading >>

What Are The Possible Side Effects Of Sitagliptin (januvia)?

What Are The Possible Side Effects Of Sitagliptin (januvia)?

A A A Medications and Drugs Brand Names: Januvia Generic Name: sitagliptin (Pronunciation: SI ta glip tin) What is sitagliptin (Januvia)? Sitagliptin is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating. Sitagliptin is for people with type 2 diabetes. Sitagliptin is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes. Sitagliptin may also be used for purposes not listed in this medication guide. What are the possible side effects of sitagliptin (Januvia)? Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking sitagliptin and call your doctor at once if you have a serious side effect such as: pancreatitis - severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, fast heart rate; or urinating less than usual or not at all; swelling, weight gain, feeling short of breath; or severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. Less serious side effects may include: runny or stuffy nose, sore throat; headache, back pain, joint or muscle pain; or This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What is the most important information I should know about sitagliptin (Januvia)? Do not use this medication if you are allergic to sitagliptin or if you are in a state of diabetic ketoa Continue reading >>

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